CN109602630B - Antibacterial whitening hand sanitizer - Google Patents

Antibacterial whitening hand sanitizer Download PDF

Info

Publication number
CN109602630B
CN109602630B CN201910066961.5A CN201910066961A CN109602630B CN 109602630 B CN109602630 B CN 109602630B CN 201910066961 A CN201910066961 A CN 201910066961A CN 109602630 B CN109602630 B CN 109602630B
Authority
CN
China
Prior art keywords
hand sanitizer
kojic acid
whitening
acid
surfactant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201910066961.5A
Other languages
Chinese (zh)
Other versions
CN109602630A (en
Inventor
付永山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan Technology & Business College
Original Assignee
Sichuan Technology & Business College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Technology & Business College filed Critical Sichuan Technology & Business College
Priority to CN201910066961.5A priority Critical patent/CN109602630B/en
Publication of CN109602630A publication Critical patent/CN109602630A/en
Application granted granted Critical
Publication of CN109602630B publication Critical patent/CN109602630B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A61K8/70Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions

Abstract

The invention discloses an antibacterial whitening hand sanitizer which comprises the following components in percentage by mass:

Description

Antibacterial whitening hand sanitizer
Technical Field
The invention relates to the technical field of detergents, and particularly relates to an antibacterial whitening hand sanitizer.
Background
Hand washing occurs most frequently in daily sanitary cleaning of people, and the hand sanitizer is usually placed in a washroom for people to use. As the hand sanitizer is used as a cleaning and nursing product specially used for washing hands, with the progress of technology, most of the hand sanitizers in the market at present are upgraded from common hand sanitizers into hand sanitizers with functions of disinfection, sterilization and skin care, and novel surfactants, auxiliaries and mild natural disinfectants are widely applied to the hand sanitizers so as to improve the performance of the hand sanitizers.
It has been found that pigmentation is associated with skin pigmentation, either as a stain or as aging progresses. When ultraviolet rays are irradiated on the skin, the skin can be protected by the skin, melanin is generated to make the skin color dull, and the skin is blackened in order to resist the melanin of the ultraviolet rays. The hands and the face of a person are always exposed to the outside like the face, and are irradiated by ultraviolet rays for a long time, and particularly in an area with high ultraviolet intensity, the skin of the hands and the face of the person is relatively dark. Because the skin of the human face is usually maintained by facial cleanser and skin care products, the skin of the human face is generally whiter than that of the human hand. However, the existing hand sanitizer in the current market generally has poor whitening effect, and some hand sanitizers even do not have skin whitening function.
Almost all hand washing solutions in the market at present can not be used for washing faces because the skin of the human face is finer and more sensitive than the skin of the hand. However, most human face skin is oily skin, and after a period of working, a large amount of oily substances are secreted on the face, so that people feel uncomfortable. Because people rarely carry the facial cleanser when working, and the hand sanitizer in the toilet cannot be used for washing the face, the toilet can only be cleaned by clean water or wiped by facial tissue, the former cannot be cleaned, and the latter requires extra economic expenditure. Especially in summer, because the weather is hot and sweat, the frequency of washing face and hands is more. In conclusion, although the existing hand sanitizer has a certain whitening function, the whitening effect is not ideal, the hand sanitizer is only used for washing hands and cannot be used for washing faces, and no report is found on the existing whitening hand sanitizer which can be used for washing hands and faces.
Disclosure of Invention
The invention aims to: the antibacterial whitening hand sanitizer has the functions of whitening and washing faces through a novel formula, and is used for solving the technical problems that the existing hand sanitizer has an ideal skin whitening effect, can only be used for washing hands and cannot be used for washing faces.
In order to solve the problems, the technical scheme adopted by the invention is as follows:
the antibacterial whitening hand sanitizer comprises the following components in percentage by mass:
Figure BDA0001956013010000011
Figure BDA0001956013010000021
preferably, the mass percent of the kojic acid and the derivatives thereof is 0.5-1.5%.
Preferably, the kojic acid derivative is one or more of kojic acid dipalmitate, kojic acid methylene dioxycinnamate, kojic acid amino acid derivative, kojic acid ether derivative and kojic acid mono-di-fatty acid ester derivative.
Preferably, the fluorocarbon surfactant is one or more of perfluoroalkyl polyether, perfluoroalkyl phosphate and perfluoroalkyl betaine.
Preferably, the nonionic surfactant is coconut oil fatty acid diethanolamide or alkyl glucoside.
Preferably, the amphoteric surfactant is one or more of coco propyl betaine, lauramidopropyl betaine, dodecyl ethoxy sulfobetaine, dodecyl hydroxypropyl sulfobetaine, dodecyl sulfopropyl betaine and tetradecamidopropyl hydroxypropyl sulfobetaine.
Preferably, the cationic surfactant is one or more of tetradecyl methyl dihydroxyethyl ammonium bromide, hexadecyl trimethyl ammonium bromide and octadecyl trimethyl ammonium chloride.
Preferably, the compound antioxidant is prepared by compounding tea polyphenol and phytic acid according to the mass ratio of 1: 1.
Preferably, the compound flavoring agent is formed by compounding pineapple essence, lemon essence and lavender essence according to the mass ratio of 1:1: 1.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. in the hand sanitizer, the fluorocarbon chain structure of the fluorocarbon surfactant is far more stable than that of a hydrocarbon structure, and fluorine atoms are very difficult to polarize, so that the polarity of the fluorocarbon chain is smaller than that of the hydrocarbon chain, and the fluorocarbon chain and one or more of a cationic surfactant, an amphoteric surfactant and a nonionic surfactant form a compound surfactant which is compounded, synergically used, so that the hand sanitizer has good thermal stability and chemical stability while the decontamination function and the disinfection and sterilization function of the hand sanitizer are enhanced, the surface tension of an aqueous solution can be reduced to a very low level by the hand sanitizer at a very low concentration, and the use amount of the hand sanitizer is greatly reduced under the same decontamination capability.
2. According to the hand sanitizer, the fluorocarbon surfactant, the cationic surfactant, the amphoteric surfactant and the nonionic surfactant are compounded and synergized, so that the antibacterial ability is greatly enhanced, the inhibition rates of staphylococcus aureus ATCC6538 and escherichia coli ATCC25922 are respectively up to 97% and 91%, the antibacterial performance is ideal, and the hand sanitizer is particularly suitable for women and children.
3. In the hand sanitizer, the kojic acid and the derivatives thereof can inhibit the synthesis of tyrosinase, can strongly absorb ultraviolet rays, effectively inhibit pigmentation caused by ultraviolet irradiation, have the effects of eliminating pigmentation, removing freckles and whitening skin and reduce skin wrinkles, so the hand sanitizer has ideal effects of removing freckles and whitening skin. Kojic acid and its derivatives have antiseptic, antibacterial and moisture keeping effects, so as to further enhance the bactericidal effect of the hand sanitizer and reduce the usage amount of the antiseptic and the humectant. In addition, the kojic acid and the derivatives thereof have the characteristics of safety, no toxicity, mild performance and no irritation to skin, when the kojic acid and the derivatives thereof are compounded with various surfactants, the performance of the hand sanitizer is mild, the skin is not damaged, and the hand sanitizer can be used for cleaning the skin of the face.
4. According to the hand sanitizer, the tea polyphenol and the phytic acid are compounded to serve as the antioxidant, so that the antioxidant performance is ideal, kojic acid and derivatives thereof can be protected from being oxidized, the whitening effect and the bacteriostasis effect of the hand sanitizer are guaranteed not to be weakened due to oxidation, and meanwhile, the quality guarantee period of a product is prolonged indirectly.
5. According to the hand sanitizer, the pineapple essence, the lemon essence and the lavender essence are adopted to form the compound fragrance blending agent, so that the hand sanitizer is fresh and elegant in fragrance, pleasant in body and mind and good in sensory experience.
6. According to the hand sanitizer, the kojic acid and the derivatives thereof have bacteriostatic and bactericidal effects, and meanwhile, the hand sanitizer containing the compound antioxidant has good antioxidant performance, so that a chemical preservative is not needed, the defect that the traditional hand sanitizer needs to be added with the chemical preservative is overcome, the performance of the hand sanitizer is mild, and no stimulation is caused to skin.
Detailed Description
All features disclosed in this specification may be combined in any combination, except features and/or steps that are mutually exclusive.
The scheme provides an antibacterial whitening hand sanitizer, a formula of the hand sanitizer forms a compound surfactant by using a special fluorocarbon surfactant and one or more of a cationic surfactant, an amphoteric surfactant and a nonionic surfactant, and the compound surfactant is compounded for synergistic use, so that the decontamination function and the disinfection and sterilization function of the hand sanitizer are enhanced; kojic acid and its derivatives are added into the formula for inhibiting pigmentation caused by ultraviolet radiation and relieving irritation of the hand sanitizer on skin, so as to enhance the sterilization and whitening effects of the hand sanitizer and be used for cleaning facial skin; meanwhile, the formula also comprises a compound antioxidant and a compound flavoring agent, so that the oxidation resistance and sensory experience of the hand sanitizer are enhanced; in addition, the formula is also added with auxiliary agents such as a humectant, a chelating agent, a viscosity control agent, a preservative and the like, so that the performance of the hand sanitizer is optimized. The following are several preferred embodiments of the antibacterial whitening hand sanitizer and corresponding comparative examples.
Example 1
The bacteriostatic whitening hand sanitizer provided by the embodiment comprises the following components in percentage by mass:
fluorocarbon surfactant: 1.0 percent; nonionic surfactant: 5 percent; amphoteric surfactant: 5 percent; cationic surfactant: 10 percent; kojic acid and its derivatives: 2 percent; humectant: 3 percent; compound antioxidant: 3 percent; compounding type flavoring agent: 0.5 percent; citric acid: 1.2 percent; NaCl: 2%, EDTA-2 Na: 1.5 percent; the balance being water.
Wherein the fluorocarbon surfactant is perfluoroalkyl polyether. The perfluoroalkyl polyether can also be replaced by perfluoroalkyl phosphate or perfluoroalkyl betaine; certainly, the perfluoroalkyl polyether, the perfluoroalkyl phosphate and the perfluoroalkyl betaine can also form more than two complex fluorocarbon surfactants, and when the two complex fluorocarbon surfactants are compounded, the fluorocarbon surfactants are compounded according to the same mass ratio.
The nonionic surfactant is coconut oil fatty acid diethanolamide or alkyl glucoside, and other nonionic surfactants such as fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, and ethylene oxide propylene oxide block polyether can also be selected.
The amphoteric surfactant is one or more of coco propyl betaine, lauramidopropyl betaine, dodecyl ethoxy sulfobetaine, dodecyl hydroxypropyl sulfobetaine, dodecyl sulfopropyl betaine and tetradecylamidopropyl hydroxypropyl sulfobetaine. Preferably cocopropyl betaine or lauramidopropyl betaine.
The cationic surfactant is one or more of tetradecyl methyl dihydroxyethyl ammonium bromide, hexadecyl trimethyl ammonium bromide and octadecyl trimethyl ammonium chloride, and is preferably tetradecyl methyl dihydroxyethyl ammonium bromide.
The kojic acid and the derivatives thereof are prepared by mixing kojic acid and kojic dipalmitate in the same mass ratio. The kojic acid dipalmitate can be compounded with one or more of kojic acid methylene dioxycinnamate, kojic acid amino acid derivatives, kojic acid ether derivatives and kojic acid mono-di-fatty acid ester derivatives in the same mass ratio.
The humectant is glycerol or propylene glycol, or glycerol in mass ratio: the propylene glycol is a mixture formed by the ratio of 1: 0.5-1. The compound antioxidant is prepared by compounding tea polyphenol and phytic acid according to the mass ratio of 1: 1.
The compound flavoring agent is prepared by compounding pineapple essence, lemon essence and lavender essence according to the mass ratio of 1:1: 1.
In this example, citric acid was used as a pH adjuster; EDTA-2Na is used as a chelating agent; NaCl acts as a viscosity control agent.
In the hand sanitizer, the fluorocarbon chain structure of the fluorocarbon surfactant is far more stable than that of a hydrocarbon structure, and fluorine atoms are very difficult to polarize, so that the polarity of the fluorocarbon chain is smaller than that of the hydrocarbon chain. It is because of this low polarity that makes the fluorocarbon chains much more hydrophobic than the hydrocarbon chains, which in turn results in weaker fluorocarbon chains interacting with each other. The two factors act together to make fluorocarbon surfactant molecules have stronger tendency than other surfactant molecules in aqueous solution to separate from the aqueous solution, and directionally aggregate and arrange into molecular films on a liquid/gas interface, so that the fluorocarbon surfactant molecules have two different characteristics from other surfactants. The special fluorocarbon surfactant and one or more of a cationic surfactant, an amphoteric surfactant and a nonionic surfactant are compounded, synergically used, so that the decontamination function and the disinfection and sterilization function of the hand sanitizer are enhanced, the hand sanitizer has good thermal stability and chemical stability, the surface tension of an aqueous solution can be reduced to a low level under a very low concentration (100-300 ppm), and the dosage of the hand sanitizer is greatly reduced under the same decontamination capability.
In the hand sanitizer, the kojic acid and the derivatives thereof can inhibit the synthesis of tyrosinase, can strongly absorb ultraviolet rays, effectively inhibit pigmentation caused by ultraviolet irradiation, have the effects of eliminating pigmentation, removing freckles and whitening skin and reduce skin wrinkles, so the hand sanitizer has ideal effects of removing freckles and whitening skin. Kojic acid and its derivatives have antiseptic, antibacterial and moisture keeping effects, so as to further enhance the bactericidal effect of the hand sanitizer and reduce the usage amount of the antiseptic and the humectant. In addition, the kojic acid and the derivatives thereof have the characteristics of safety, no toxicity, mild performance and no irritation to skin, when the kojic acid and the derivatives thereof are compounded with various surfactants, the performance of the hand sanitizer is mild, the skin is not damaged, and the hand sanitizer can be used for cleaning the skin of the face.
Example 2
This example differs from example 1 in that: in the formula of the antibacterial whitening hand sanitizer, the fluorocarbon surfactant is perfluoroalkyl phosphate, and the mass percentage of the fluorocarbon surfactant is 0.5%; the mass percent of the citric acid is 1.0 percent; the kojic acid and the derivatives thereof account for 2 percent by mass and are prepared by mixing kojic acid and kojic acid methylene dioxycinnamate in the same mass ratio.
Example 3
This example differs from example 1 in that: in the formula of the antibacterial whitening hand sanitizer, the fluorocarbon surfactant is perfluoroalkyl phosphate, and the mass percentage of the fluorocarbon surfactant is 1.5%; the mass percent of the citric acid is 1.3 percent; the kojic acid and the derivatives thereof account for 2 percent by mass and are prepared by mixing kojic acid and kojic acid methylene dioxycinnamate in the same mass ratio.
Example 4
This example differs from example 1 in that: in the formula of the antibacterial whitening hand sanitizer, the kojic acid and derivatives thereof account for 0.5 percent by mass and are prepared by mixing kojic acid and kojic dipalmitate in the same mass ratio; the mass percentage of the citric acid is 0.8%.
Example 5
This example differs from example 1 in that: in the formula of the antibacterial whitening hand sanitizer, the kojic acid and derivatives thereof account for 1.5 percent by mass and are prepared by mixing kojic acid and dipalmitate of kojic acid in the same mass ratio; the mass percentage of the citric acid is 0.8%.
Example 6
This example differs from example 1 in that: in the formula of the antibacterial whitening hand sanitizer, the kojic acid and derivatives thereof account for 6% by mass, and the hand sanitizer is prepared by mixing kojic acid, kojic acid dipalmitate and kojic acid dipalmitate in a mass ratio of 1:1: 1; the mass percentage of the citric acid is 1.5%.
Example 7
This example is a comparative example, differing from example 1 in that: the formula of the antibacterial whitening hand sanitizer does not contain fluorocarbon surfactant.
Example 8
This example is a comparative example, differing from example 1 in that: the antioxidant in this example was only tea polyphenol, and its mass percentage was 3%.
Example 9
This example is a comparative example, differing from example 1 in that: the antioxidant in this example is phytic acid alone, and the mass percentage thereof is 3%.
Example 10
This example is a comparative example, differing from example 1 in that: the formula of the antibacterial whitening hand sanitizer does not contain a compound flavoring agent, but is independently added with any one of pineapple essence, lemon essence and lavender essence.
The antibacterial and whitening hand sanitizer of the above embodiments is subjected to an acid-base experiment, a sensory experience and an oxidation resistance experiment, and specific experimental methods and results are as follows.
(1) Acid-base experiment: when the bacteriostatic whitening hand sanitizer in the embodiments 1 to 6 is detected by using a pH meter, the pH of the bacteriostatic whitening hand sanitizer is within the range of 6.0 to 6.5, the bacteriostatic whitening hand sanitizer is weakly acidic, and no stimulation is caused to skin, and specific results are shown in Table 1.
Table 1: experimental result of acidity and alkalinity of bacteriostatic whitening hand sanitizer
Examples 1 2 3 4 5 6
pH value 6.4 6.0 6.4 6.1 6.5 6.3
(2) Bacteriostatic experiments: the hand sanitizer of the embodiments 1 to 7 is prepared by carrying out bacteriostatic experiment effect tests according to national industry standard QB/T2850-2007 bacteriostatic detergents, wherein the concentrations are 1% by mass, the action time is 20 minutes, and the data are shown in the following table.
Table 2: bacteriostatic test result of bacteriostatic whitening hand sanitizer
Figure BDA0001956013010000061
As can be seen from table 2, examples 1 to 3 all have good effects of inhibiting bacterial growth, and particularly, example 3 is significantly superior to examples 1 and 2, and it can be seen that the synergistic effect and the antibacterial effect are significant by adding the fluorocarbon surfactant, the cation and the nonionic for compound use; in example 7, the bacteriostatic ability is greatly reduced without adding fluorocarbon surfactant. Examples 1,4,5 and 6 show that the bacteriostatic effect is enhanced when the amount of kojic acid and its derivatives is changed under the condition of consistent fluorocarbon surfactant.
(3) Sensory experience: the number of 10 people is shown in double-blind trial, after the pineapple essence, the lemon essence and the lavender essence are respectively and independently added into the bacteriostatic and whitening hand sanitizer in the embodiment 10, the experiment participants smell fragrance and express sensory experience, and then the bacteriostatic and whitening hand sanitizer in the embodiments 1-6 is used for the experiment participants to smell fragrance. The sensory description of the latter by the experimental participants is fresh and elegant fragrance, pleasure in mind and body, and the sensory experience is better than that of the former three, so that the compound fragrance agent can endow the hand sanitizer with refreshing and pleasant fragrance.
(4) Oxidation resistance test: the bacteriostatic whitening hand sanitizer prepared in the example 1, the example 8 and the example 9 is placed in a constant-temperature oven with the temperature of 50 ℃, the temperature is kept for 48 hours in an open mode, and the discoloration condition of a sample is observed, and the result is shown in the following table 3.
Table 3: experimental result of oxidation resistance of antibacterial whitening hand sanitizer
Examples Tea polyphenol phytic acid 1:1 Tea polyphenols Phytic acid
1 Has no change / /
8 / Color change, light yellow /
9 / / Color change, deep yellow
Therefore, the invention adopts the tea polyphenol and the phytic acid to be compounded for use, has better antioxidant effect than that of the single use, and can protect kojic acid from being oxidized.
The embodiment provides an antibacterial whitening hand sanitizer, which comprises the following components in percentage by mass:
although the present invention has been described with reference to specific embodiments, it should be understood that the present invention is not limited thereto, and various modifications, substitutions and alterations can be made by those skilled in the art without creative efforts based on the technical scheme of the present invention.

Claims (5)

1. The antibacterial whitening hand sanitizer is characterized by comprising the following components in percentage by mass:
Figure FDA0003279427580000011
the fluorocarbon surfactant is one or more of perfluoroalkyl polyether, perfluoroalkyl phosphate and perfluoroalkyl betaine, the nonionic surfactant is coconut oil fatty acid diethanolamide or alkyl glucoside, the cationic surfactant is one or more of tetradecyl methyl dihydroxyethyl ammonium bromide, hexadecyl trimethyl ammonium bromide and octadecyl trimethyl ammonium chloride, and the compound antioxidant is prepared by compounding tea polyphenol and phytic acid according to the mass ratio of 1: 1.
2. The bacteriostatic whitening hand sanitizer according to claim 1, wherein the mass percentage of kojic acid and derivatives thereof is 0.5-1.5%.
3. The bacteriostatic and whitening hand sanitizer according to claim 1 or 2, wherein the kojic acid derivative is one or more of kojic acid dipalmitate, kojic acid methylene dioxycinnamate, kojic acid amino acid derivative, kojic acid ether derivative and kojic acid mono-di-fatty acid ester derivative.
4. The antibacterial whitening hand sanitizer according to claim 1, wherein the amphoteric surfactant is one or more of cocamidopropyl betaine, lauramidopropyl betaine, dodecyl ethoxy sulfobetaine, dodecyl hydroxypropyl sulfobetaine, dodecyl sulfopropyl betaine and tetradecanamidopropyl hydroxypropyl sulfobetaine.
5. The bacteriostatic and whitening hand sanitizer according to claim 1, wherein the compound flavoring agent is prepared by compounding pineapple essence, lemon essence and lavender essence according to a mass ratio of 1:1: 1.
CN201910066961.5A 2019-01-24 2019-01-24 Antibacterial whitening hand sanitizer Active CN109602630B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910066961.5A CN109602630B (en) 2019-01-24 2019-01-24 Antibacterial whitening hand sanitizer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910066961.5A CN109602630B (en) 2019-01-24 2019-01-24 Antibacterial whitening hand sanitizer

Publications (2)

Publication Number Publication Date
CN109602630A CN109602630A (en) 2019-04-12
CN109602630B true CN109602630B (en) 2021-12-07

Family

ID=66018209

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910066961.5A Active CN109602630B (en) 2019-01-24 2019-01-24 Antibacterial whitening hand sanitizer

Country Status (1)

Country Link
CN (1) CN109602630B (en)

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4961923A (en) * 1988-02-19 1990-10-09 Dentsply Management Corp. Irrigants for use in scaling and/or lavage apparatus
WO2002091848A1 (en) * 2001-05-15 2002-11-21 The Procter & Gamble Company Confectionery compositions
CN1671689A (en) * 2002-07-31 2005-09-21 西巴特殊化学品控股有限公司 Pyridyl-triazine derivatives as microbicidal active substances
CN1713881A (en) * 2002-11-13 2005-12-28 J·M·休伯有限公司 Abrasive compositions for clear toothpaste
CN101170904A (en) * 2005-03-07 2008-04-30 戴博全球保健有限公司 High alcohol content foaming compositions with silicone-based surfactants
CN101427990A (en) * 2008-12-12 2009-05-13 上海蔻漫生物科技有限公司 Skin cleaning article
CN101684435A (en) * 2008-09-28 2010-03-31 福建恒安集团有限公司 Sterilization hand washing solution
WO2010147868A2 (en) * 2009-06-15 2010-12-23 Gojo Industries, Inc. Antimicrobial compositions
WO2011072002A2 (en) * 2009-12-08 2011-06-16 The Procter & Gamble Company A porous, dissolvable solid substrate and surface resident coating comprising water sensitive actives
CN103212339A (en) * 2013-04-28 2013-07-24 东华大学 Hyamine fluorocarbon surfactant as well as preparation method and application thereof
CN104306176A (en) * 2014-09-23 2015-01-28 广州大学 Quaternary ammonium salt type antibacterial hand washing solution
CN106309281A (en) * 2016-09-22 2017-01-11 长兴净安环保科技有限公司 Anti-bacteria foam hand sanitizer and preparation method thereof
CN106821950A (en) * 2017-01-23 2017-06-13 衡阳美娇七商贸有限公司 The oral care composition and its application of a kind of antibacterial and whitening
EP3187165A1 (en) * 2015-12-29 2017-07-05 The Dial Corporation Foaming hand sanitizers
CN109010157A (en) * 2018-10-31 2018-12-18 广东药科大学 A kind of purposes of 6- flumizole and pyridine derivate

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4961923A (en) * 1988-02-19 1990-10-09 Dentsply Management Corp. Irrigants for use in scaling and/or lavage apparatus
WO2002091848A1 (en) * 2001-05-15 2002-11-21 The Procter & Gamble Company Confectionery compositions
CN1671689A (en) * 2002-07-31 2005-09-21 西巴特殊化学品控股有限公司 Pyridyl-triazine derivatives as microbicidal active substances
CN1713881A (en) * 2002-11-13 2005-12-28 J·M·休伯有限公司 Abrasive compositions for clear toothpaste
CN101170904A (en) * 2005-03-07 2008-04-30 戴博全球保健有限公司 High alcohol content foaming compositions with silicone-based surfactants
CN101684435A (en) * 2008-09-28 2010-03-31 福建恒安集团有限公司 Sterilization hand washing solution
CN101427990A (en) * 2008-12-12 2009-05-13 上海蔻漫生物科技有限公司 Skin cleaning article
WO2010147868A2 (en) * 2009-06-15 2010-12-23 Gojo Industries, Inc. Antimicrobial compositions
WO2011072002A2 (en) * 2009-12-08 2011-06-16 The Procter & Gamble Company A porous, dissolvable solid substrate and surface resident coating comprising water sensitive actives
CN103212339A (en) * 2013-04-28 2013-07-24 东华大学 Hyamine fluorocarbon surfactant as well as preparation method and application thereof
CN104306176A (en) * 2014-09-23 2015-01-28 广州大学 Quaternary ammonium salt type antibacterial hand washing solution
EP3187165A1 (en) * 2015-12-29 2017-07-05 The Dial Corporation Foaming hand sanitizers
CN106309281A (en) * 2016-09-22 2017-01-11 长兴净安环保科技有限公司 Anti-bacteria foam hand sanitizer and preparation method thereof
CN106821950A (en) * 2017-01-23 2017-06-13 衡阳美娇七商贸有限公司 The oral care composition and its application of a kind of antibacterial and whitening
CN109010157A (en) * 2018-10-31 2018-12-18 广东药科大学 A kind of purposes of 6- flumizole and pyridine derivate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Application of several novel natural antioxidants to inhibit oxidation of tree peony seed oil";Zhangzhen Bai等;《CYTA-JOURNAL OF FOOD》;20181128;第16卷(第1期);第1071-1078页 *
"植酸/植酸钠在食品工业上的应用研究进展";沙如意等;《现代食品科技》;20181231;第34卷(第6期);第293-309页 *

Also Published As

Publication number Publication date
CN109602630A (en) 2019-04-12

Similar Documents

Publication Publication Date Title
BR112012006614A2 (en) method for disinfecting the surface, microbicidal composition, liquid microbicidal composition, solid microbicidal composition and use of a composition
BRPI0811071A2 (en) PRODUCTS, MICROBICIDE COMPOSITIONS, AND METHODS OF USE
JP2009007266A (en) Silver ion water for cosmetic and low-irritant cosmetic using the same
PL173704B1 (en) Bactericidal mouth wash
EP1786391A1 (en) Antimicrobial skin composition comprising a biguanide or a quaternium compound
KR20170040524A (en) A method wipes containing the composition without the irritation on bamboo fabric
JP2011074082A (en) Antiseptic sterilizer and composition for application to human body
CN105255596B (en) A kind of Antibiotic liquid detergent containing Folium Artemisiae Argyi extract
KR101308959B1 (en) Low-Irritative Powder Composition for Washing
CN107854329B (en) A kind of antibacterial moisturizing foam hand cleanser of easy wash type and preparation method thereof
CN109602630B (en) Antibacterial whitening hand sanitizer
JPWO2011013494A1 (en) Aqueous composition
KR101086926B1 (en) Disinfectant composition for hand including mastic
JP4734293B2 (en) Antiseptic disinfectant and human body composition
KR101552646B1 (en) Cleansing cosmetic composition comprising eudialyte and bentonite
BRPI0718501A2 (en) USE OF A COMPOUND AND METHOD FOR COMBATING DENTAL EROSION AND / OR TEETH WEAR
KR19980087633A (en) Silver Soap Manufacturing Method
JP3522380B2 (en) Bath composition
JPH07196463A (en) Composition for oral cavity
BR112014013033B1 (en) microbicidal composition, non-therapeutic method for providing a microbicidal effect to the skin and non-therapeutic use of a composition
KR20170141870A (en) Mouth and nose cleaning liquid comprising oxygen
JP2010195706A (en) New germicidal, fungicidal and moisturizing composition
KR20070109000A (en) Hand wash compositions
JPH08198738A (en) Liquid cosmetic composition for skin
KR102633791B1 (en) Composition comprising phosphate for removal biofilm

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant