CN109602630A - A kind of antibacterial skin-whitening liquid soap - Google Patents
A kind of antibacterial skin-whitening liquid soap Download PDFInfo
- Publication number
- CN109602630A CN109602630A CN201910066961.5A CN201910066961A CN109602630A CN 109602630 A CN109602630 A CN 109602630A CN 201910066961 A CN201910066961 A CN 201910066961A CN 109602630 A CN109602630 A CN 109602630A
- Authority
- CN
- China
- Prior art keywords
- liquid soap
- skin
- whitening liquid
- antibacterial skin
- kojic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 41
- 239000007788 liquid Substances 0.000 title claims abstract description 39
- 239000000344 soap Substances 0.000 title claims abstract description 35
- 229960004705 kojic acid Drugs 0.000 claims abstract description 43
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims abstract description 43
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000004094 surface-active agent Substances 0.000 claims abstract description 25
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims abstract description 22
- -1 kojic acid methylene umbellic acid ester Chemical class 0.000 claims description 19
- 230000003078 antioxidant effect Effects 0.000 claims description 10
- 239000003963 antioxidant agent Substances 0.000 claims description 9
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 8
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 8
- 239000002736 nonionic surfactant Substances 0.000 claims description 8
- 239000000467 phytic acid Substances 0.000 claims description 8
- 229940068041 phytic acid Drugs 0.000 claims description 8
- 235000002949 phytic acid Nutrition 0.000 claims description 8
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 8
- 235000013824 polyphenols Nutrition 0.000 claims description 8
- 239000002781 deodorant agent Substances 0.000 claims description 7
- 235000005979 Citrus limon Nutrition 0.000 claims description 6
- 244000131522 Citrus pyriformis Species 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 6
- 244000269722 Thea sinensis Species 0.000 claims description 6
- 239000002280 amphoteric surfactant Substances 0.000 claims description 6
- 239000003093 cationic surfactant Substances 0.000 claims description 6
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 6
- 229920000570 polyether Polymers 0.000 claims description 6
- 244000099147 Ananas comosus Species 0.000 claims description 5
- 235000007119 Ananas comosus Nutrition 0.000 claims description 5
- 241001597008 Nomeidae Species 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 claims description 3
- BGHCVCJVXZWKCC-UHFFFAOYSA-N tetradecane Chemical compound CCCCCCCCCCCCCC BGHCVCJVXZWKCC-UHFFFAOYSA-N 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- BHUGZIJOVAVBOQ-UHFFFAOYSA-N 2-(propylazaniumyl)acetate Chemical compound CCCNCC(O)=O BHUGZIJOVAVBOQ-UHFFFAOYSA-N 0.000 claims 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 229960003237 betaine Drugs 0.000 claims 1
- 235000019864 coconut oil Nutrition 0.000 claims 1
- 239000003240 coconut oil Substances 0.000 claims 1
- OAPPHVGUEZMLNX-UHFFFAOYSA-N ethyl(dihydroxy)azanium;bromide Chemical compound [Br-].CC[NH+](O)O OAPPHVGUEZMLNX-UHFFFAOYSA-N 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 235000019198 oils Nutrition 0.000 claims 1
- 230000002087 whitening effect Effects 0.000 abstract description 11
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 238000004140 cleaning Methods 0.000 abstract description 6
- 230000001815 facial effect Effects 0.000 abstract description 6
- 230000019612 pigmentation Effects 0.000 abstract description 6
- 239000003755 preservative agent Substances 0.000 abstract description 6
- 230000002335 preservative effect Effects 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 230000001408 fungistatic effect Effects 0.000 abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- 230000006870 function Effects 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- URJOWNUVTORLNY-UHFFFAOYSA-N (5-hexadecanoyloxy-4-oxopyran-2-yl) hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC1=CC(=O)C(OC(=O)CCCCCCCCCCCCCCC)=CO1 URJOWNUVTORLNY-UHFFFAOYSA-N 0.000 description 7
- 238000013329 compounding Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000001953 sensory effect Effects 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 239000004909 Moisturizer Substances 0.000 description 5
- 208000012641 Pigmentation disease Diseases 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 230000001333 moisturizer Effects 0.000 description 5
- 208000003351 Melanosis Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- PIJMLPSNVMZDSW-UHFFFAOYSA-M [Br-].C(CCCCCCCCCCCCCCC)[N+](O)(O)C Chemical group [Br-].C(CCCCCCCCCCCCCCC)[N+](O)(O)C PIJMLPSNVMZDSW-UHFFFAOYSA-M 0.000 description 3
- 230000003026 anti-oxygenic effect Effects 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 150000001768 cations Chemical group 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 238000002845 discoloration Methods 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 description 3
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 102000003425 Tyrosinase Human genes 0.000 description 2
- 108060008724 Tyrosinase Proteins 0.000 description 2
- PRPAGESBURMWTI-UHFFFAOYSA-N [C].[F] Chemical compound [C].[F] PRPAGESBURMWTI-UHFFFAOYSA-N 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- YFVKHKCZBSGZPE-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-2-(propylamino)propan-1-one Chemical compound CCCNC(C)C(=O)C1=CC=C2OCOC2=C1 YFVKHKCZBSGZPE-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001360526 Escherichia coli ATCC 25922 Species 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000031709 bromination Effects 0.000 description 1
- 238000005893 bromination reaction Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- QEALYLRSRQDCRA-UHFFFAOYSA-N myristamide Chemical compound CCCCCCCCCCCCCC(N)=O QEALYLRSRQDCRA-UHFFFAOYSA-N 0.000 description 1
- 239000002120 nanofilm Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
- A61K8/70—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biotechnology (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
The invention discloses a kind of antibacterial skin-whitening liquid soaps, are calculated by mass percentage, and formula includes following component:
Description
Technical field
The present invention relates to detergent technical fields, and in particular to a kind of antibacterial skin-whitening liquid soap.
Background technique
Washing one's hands is that the frequency occurs in the cleaning of people's daily hygiene at most, and hand cleanser is generally positioned at toilet or toilet
It is for people to use.Hand cleanser is as the cleaning nursing article dedicated for washing one's hands, with advances in technology, currently on the market big
Part hand cleanser from common hand cleanser upgraded to disinfection, sterilization and skin care hand cleanser, novel surfactant,
Auxiliary agent and mild natural elimination agent are widely applied in hand cleanser, to improve the performance of hand cleanser.
The study found that skin generates color spot or aging is related with melanin.Ultraviolet light irradiates on the skin, and skin understand this
The self-protection of energy, generating melanin by the colour of skin becomes dim, and skin makes skin become blackening to resist the melanin of ultraviolet light.
The hand of people is constantly exposed to outside as face, can be irradiated with ultraviolet radiation for a long time, especially the big area of uitraviolet intensity,
The hand of people and the skin of face are all more black.Since face skin is maintained commonly using facial cleanser and skin care item, usual face skin
It is white compared with skin of hand.And currently on the market, usual whitening effect is bad in existing hand cleanser, and some does not have skin-whitening even
Function.
Since face skin is finer and smoother compared with skin of hand, more sensitive, almost all of hand cleanser cannot all be used currently on the market
In washing one's face.However most people's face skin is Oily, after a period of work, chance is secreted a large amount of oily matters and is allowed on the face
People does not feel good.Due to can seldom carry facial cleanser when people's work, and the hand cleanser of toilet cannot be used for washing one's face again, only
It can be cleaned by clear water or be wiped with face tissue, the former does not wash clean clearly, and the latter needs additional economic to pay.Especially in the summer
It washes one's face because hot weather can perspire and washes one's hands number meeting more.To sum up, although existing hand cleanser has certain white function
Can, but whitening effect is unsatisfactory, and is only limitted to wash one's hands, it is impossible to be used in and it washes one's face, has both the whitening washed one's hands and washed one's face at present and wash
Hand liquid has not been reported.
Summary of the invention
It is an object of the invention to: a kind of antibacterial skin-whitening liquid soap is provided, has the hand cleanser not only by new formula
Have bacteriostasis efficacy, also have the function of whitening and wash one's face, for solve existing hand cleanser there are skin whitening effects ideal, can only
For washing one's hands, it is impossible to be used in the technical issues of washing one's face.
To solve the above problems, The technical solution adopted by the invention is as follows:
A kind of antibacterial skin-whitening liquid soap, is calculated by mass percentage, and formula includes following component:
Preferably, the mass percent of the kojic acid and its derivative is 0.5~1.5%.
Preferably, the derivative of kojic acid is kojic dipalmitate, kojic acid methylene umbellic acid ester, kojic acid amino
One of acid derivative, kojic acid ether derivant, kojic acid list bis-fatty acid ester derivant are a variety of.
Preferably, the fluorocarbon surfactant is perfluoroalkyl polyethers, perfluoralkyl phosphate, perfluoroalkyl betain
One of or it is a variety of.
Preferably, the nonionic surfactant is cocoanut fatty acid diethanolamide or alkyl-glucoside.
Preferably, the amphoteric surfactant is cocounut oil propyl betaine, lauroylamidopropyl betaine, dodecyl
Ethyoxyl sulfobetaines, dodecyl hydroxypropyl sulfobetaines, dodecyl azochlorosulfonate propyl lycine, myristamide propyl
One of hydroxypropyl sulfobetaines is a variety of.
Preferably, the cationic surfactant is tetradecylmethyl dihydroxy ethyl ammonium bromide, cetyl front three
One of base ammonium bromide, octadecyltrimethylammonium chloride are a variety of.
Preferably, the Compositional type antioxidant is that tea polyphenols and phytic acid are compounded according to mass ratio 1:1.
Preferably, the Compositional type deodorant tune is flavoring pineapple essence, lemon extract, lavender oil according to mass ratio 1:1:1
It compounds.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
1. in hand cleanser described in this programme, since the fluorocarbon chain structure of fluorocarbon surfactant is more than hydrocarbon stable structure,
And fluorine atom is very difficult to be polarized, and keeps fluorocarbon chain polarity smaller than hydrocarbon chain, it is living with cationic surfactant, amphoteric surface
Property agent, one of nonionic surfactant or a variety of formation built surfactants, compound it is synergistic use, increasing
The dirt-removing functions and disinfecting and sterilizing functions of strong hand cleanser simultaneously, also make hand cleanser have good thermal stability and chemical stabilization
Property, aqueous solution surface tension can dropped to very low level by hand cleanser at very low concentrations, under identical dirt-removing power, be washed
The dosage of hand liquid is greatly reduced.
2. hand cleanser described in this programme using fluorocarbon surfactant and cationic surfactant, amphoteric surface due to being lived
Property agent, nonionic surfactant compounding it is synergistic so that bacteriostasis substantially enhances, to staphylococcus aureus
The inhibiting rate of ATCC6538 and Escherichia coli ATCC25922 are up to 97% and 91% respectively, and bacteriostasis property is ideal, especially suitable for
Women, children use.
3. in hand cleanser described in this programme, the kojic acid and its derivative can inhibit the synthesis of tyrosinase, and can be strong
Strong absorption ultraviolet light effectively inhibits the pigmentation caused by ultraviolet light irradiation, eliminates pigmentation, nti-freckle, the function brightened
Effect reduces wrinkle of skin, therefore the hand cleanser has effects that ideal nti-freckle, whitening.Kojic acid and its derivative have anti-corrosion, suppression
Bacterium, moisturizing effect reduce the usage amount of preservative and moisturizer so that hand cleanser bactericidal effect further enhances.In addition, bent
Acid and its derivative have safe and non-toxic, performance it is mild, to the characteristic of no skin irritation, when kojic acid and its derivative and each table
When face activating agent compounds, the performance of hand cleanser is made to become mildly, not injure skin, which can be used for facial skin cleaning.
4. hand cleanser described in this programme is used as antioxidant using tea polyphenols and phytic acid compounding, antioxygenic property is ideal, can
To protect kojic acid and its derivative not oxidized, to guarantee that whitening effect and the fungistatic effect of hand cleanser do not weaken because of oxidation,
Extend the shelf-life of product indirectly simultaneously.
5. hand cleanser described in this programme forms Compositional type deodorant tune using flavoring pineapple essence, lemon extract and lavender oil,
Fragrance is elegant and tasteful, and body and mind is pleasant, and sensory experience is good.
6. hand cleanser described in this programme, kojic acid and its derivative have effects that restraining and sterilizing bacteria, while Compositional type antioxidant
The hand cleanser for being has good antioxygenic property, there is no need to use chemical preservative, overcomes traditional hand cleanser needs and adds
Add the defect of chemical preservative, so that hand cleanser performance becomes mildly, it is non-stimulated to skin.
Specific embodiment
All features disclosed in this specification can be with any other than mutually exclusive feature and/or step
Mode combines.
This programme provides a kind of antibacterial skin-whitening liquid soap, and formula passes through special fluorocarbon surfactant and cation form
One of face activating agent, amphoteric surfactant, nonionic surfactant or a variety of formation built surfactants, it is multiple
It is used with synergy, enhances the dirt-removing functions and disinfecting and sterilizing functions of hand cleanser；Kojic acid and its derivative are added in formula, uses
By the caused pigmentation of ultraviolet light irradiation and hand cleanser is mitigated to the stimulation of skin, to enhance hand cleanser in inhibition
Sterilization and whitening effect, and can be used for cleaning facial skin；Meanwhile also there is Compositional type antioxidant and Compositional type tune in formula
Pastil enhances the antioxygenic property and sensory experience of hand cleanser；In addition, being also added with moisturizer, chelating agent, viscosity control in formula
The auxiliary agents such as preparation, preservative optimize the performance of hand cleanser.It is several preferred realities of antibacterial skin-whitening liquid soap described in this programme below
Apply mode and corresponding comparative example.
Embodiment 1
A kind of antibacterial skin-whitening liquid soap provided in this embodiment, is calculated by mass percentage, and formula includes such as the following group
Point:
Fluorocarbon surfactant: 1.0%；Nonionic surfactant: 5%；Amphoteric surfactant: 5%；Cation form
Face activating agent: 10%；Kojic acid and its derivative: 2%；Moisturizer: 3%；Compositional type antioxidant: 3%；Compositional type deodorant tune:
0.5%；Citric acid: 1.2%；NaCl:2%, EDTA-2Na:1.5%；Surplus is water.
Wherein, the fluorocarbon surfactant is perfluoroalkyl polyethers.Perfluoroalkyl phosphorus also can be selected in perfluoroalkyl polyethers
Acid esters or perfluoroalkyl betain substitution；It is of course also possible to by perfluoroalkyl polyethers, perfluoralkyl phosphate and perfluoroalkyl
Glycine betaine forms the fluorocarbon surfactant of two or more Compositional types, when compounding, with identical between each fluorocarbon surfactant
Mass ratio compounding.
The nonionic surfactant is cocoanut fatty acid diethanolamide or alkyl-glucoside, can also be selected
Other nonionic surfactants, such as fatty alcohol polyoxyethylene ether, alkyl phenol polyoxyethylene ether, ethylene oxide propylene oxide
Block polyether.
The amphoteric surfactant is cocounut oil propyl betaine, lauroylamidopropyl betaine, dodecyl ethyoxyl
Sulfobetaines, dodecyl hydroxypropyl sulfobetaines, dodecyl azochlorosulfonate propyl lycine, myristamide propyl hydroxypropyl
One of sulfobetaines is a variety of.Preferably cocounut oil propyl betaine or lauroylamidopropyl betaine.
The cationic surfactant is tetradecylmethyl dihydroxy ethyl ammonium bromide, cetyl trimethyl bromination
One of ammonium, octadecyltrimethylammonium chloride are a variety of, preferably tetradecylmethyl dihydroxy ethyl ammonium bromide.
The kojic acid and its derivative are to be mixed by kojic acid and kojic dipalmitate with identical mass ratio.It is described
Kojic dipalmitate can be with kojic acid methylene umbellic acid ester, kojic acid amino acid derivativges, kojic acid ether derivant, kojic acid list
One of bis-fatty acid ester derivant is a variety of with identical mass ratio compounding.
The moisturizer be glycerol perhaps propylene glycol or with quality than glycerol: propylene glycol is the ratio shape of 1:0.5~1
At mixture.The Compositional type antioxidant is that tea polyphenols and phytic acid are compounded according to mass ratio 1:1.
The Compositional type deodorant tune be flavoring pineapple essence, lemon extract, lavender oil according to mass ratio 1:1:1 compound and
At.
In the present embodiment, citric acid is as pH adjusting agent；EDTA-2Na is as chelating agent；NaCl is controlled as viscosity
Agent.
In hand cleanser described in this programme, since the fluorocarbon chain structure of fluorocarbon surfactant is more than hydrocarbon stable structure, and
Fluorine atom is very difficult to be polarized, and keeps fluorocarbon chain polarity smaller than hydrocarbon chain.Exactly because this low polarity makes the hydrophobic work of fluorocarbon chain
With strong more than hydrocarbon chain, low polarity causes the mutual active force of fluorocarbon chain weak again.This two factor collective effects make fluorine carbon
Surfactant molecule have the tendency that in aqueous solution it is than other surfactant molecules stronger be detached from aqueous solution,
Orientation aggregation is arranged in molecular film on liquid/gas interface, to make it have the two kind characteristics different from other surfactants.
Because by this special fluorocarbon surfactant and cationic surfactant, amphoteric surfactant, non-ionic surface active
One of agent or a variety of formation built surfactants compound synergistic use, in the dirt-removing functions of enhancing hand cleanser
Simultaneously with disinfecting and sterilizing functions, also make hand cleanser that there is good thermal stability and chemical stability, hand cleanser is very low
Concentration under (100~300ppm) aqueous solution surface tension can be dropped to very low level, under identical dirt-removing power, hand cleanser
Dosage is greatly reduced.
In hand cleanser described in this programme, the kojic acid and its derivative can inhibit the synthesis of tyrosinase, and can be strong
Ultraviolet light is absorbed, the pigmentation caused by ultraviolet light irradiation is effectively inhibited, the effect of eliminating pigmentation, nti-freckle, brighten,
Wrinkle of skin is reduced, therefore the hand cleanser has effects that ideal nti-freckle, whitening.Kojic acid and its derivative have anti-corrosion, it is antibacterial,
The effect of moisturizing reduces the usage amount of preservative and moisturizer so that hand cleanser bactericidal effect further enhances.In addition, kojic acid
And its derivative have safe and non-toxic, performance it is mild, to the characteristic of no skin irritation, when kojic acid and its derivative and each surface
When activating agent compounds, the performance of hand cleanser is made to become mildly, not injure skin, which can be used for facial skin cleaning.
Embodiment 2
The present embodiment is unlike the first embodiment: in the formula of antibacterial skin-whitening liquid soap, the fluorocarbon surfactant is
Perfluoralkyl phosphate, mass percent 0.5%；The mass percent of citric acid is 1.0%；Kojic acid and its derivative
Mass percent is 2%, is mixed by kojic acid and kojic acid methylene umbellic acid ester with identical mass ratio.
Embodiment 3
The present embodiment is unlike the first embodiment: in the formula of antibacterial skin-whitening liquid soap, the fluorocarbon surfactant is
Perfluoralkyl phosphate, mass percent 1.5%；The mass percent of citric acid is 1.3%；Kojic acid and its derivative
Mass percent is 2%, is mixed by kojic acid and kojic acid methylene umbellic acid ester with identical mass ratio.
Embodiment 4
The present embodiment is unlike the first embodiment: in the formula of antibacterial skin-whitening liquid soap, the quality of kojic acid and its derivative
Percentage is 0.5%, is mixed by kojic acid and kojic dipalmitate with identical mass ratio；The mass percent of citric acid is
0.8%.
Embodiment 5
The present embodiment is unlike the first embodiment: in the formula of antibacterial skin-whitening liquid soap, the quality of kojic acid and its derivative
Percentage is 1.5%, is mixed by kojic acid and kojic dipalmitate with identical mass ratio；The mass percent of citric acid is
0.8%.
Embodiment 6
The present embodiment is unlike the first embodiment: in the formula of antibacterial skin-whitening liquid soap, the quality of kojic acid and its derivative
Percentage is 6%, is mixed by kojic acid and kojic dipalmitate, kojic dipalmitate with mass ratio 1:1:1；Citric acid
Mass percent be 1.5%.
Embodiment 7
The present embodiment is comparative example, unlike the first embodiment: in the formula of antibacterial skin-whitening liquid soap, not containing fluorine carbon
Surfactant.
Embodiment 8
The present embodiment is comparative example, unlike the first embodiment: tea polyphenols are used only in the antioxidant in the present embodiment,
Its mass percent is 3%.
Embodiment 9
The present embodiment is comparative example, unlike the first embodiment: phytic acid is used only in the antioxidant in the present embodiment,
Mass percent is 3%.
Embodiment 10
The present embodiment is comparative example, unlike the first embodiment: not adding Compositional type in the formula of antibacterial skin-whitening liquid soap
Deodorant tune, but individually add flavoring pineapple essence, lemon extract, any one in lavender oil.
Acid-base property experiment, sensory experience and inoxidizability are carried out to the antibacterial skin-whitening liquid soap of above-mentioned several embodiments respectively
Experiment, specific experiment method and result are as follows.
(1) acid-base property is tested: being detected with antibacterial skin-whitening liquid soap of the pH meter to Examples 1 to 6, antibacterial whitening is washed one's hands
The pH of liquid is weakly acidic in 6.0~6.5 ranges, and non-stimulated to skin, concrete outcome is shown in Table 1.
Table 1: antibacterial skin-whitening liquid soap acid-base property experimental result
| Embodiment | 1 | 2 | 3 | 4 | 5 | 6 |
| PH value | 6.4 | 6.0 | 6.4 | 6.1 | 6.5 | 6.3 |
(2) bacteriostatic experiment: the hand cleanser of Examples 1 to 7, according to the antibacterial type type of national sector standard QB/T2850~2007
Detergent carries out bacteriostatic experiment measure of merit, and concentration is mass ratio 1%, and action time is 20 minutes, data such as following table.
Table 2: antibacterial skin-whitening liquid soap bacteriostatic experiment result
As can be drawn from Table 2, Examples 1 to 3 can inhibit bacterial growth, especially embodiment 3 to be substantially better than well
Examples 1 and 2, it is seen that be used in compounding by the way that fluorocarbon surfactant and cation, nonionic is added, synergistic, antibacterial effect
Fruit is obvious；And fluorocarbon surfactant is not added in embodiment 7, bacteriostasis substantially weakens.Embodiment 1,4,5,6 indicates fluorine
In the consistent situation of carbon surface active agent, fungistatic effect after changing the dosage of kojic acid and its derivative, when kojic acid and its derivative
Dosage increase, fungistatic effect enhancing.
(3) sensory experience: 10 people of number, double blind is on probation, and the antibacterial skin-whitening liquid soap of embodiment 10 individually adds spinach
After trailing plants essence, lemon extract, lavender oil, experiment participant is allowed to hear fragrant, and express sensory experience, then again by embodiment 1
It is fragrant that~6 antibacterial skin-whitening liquid soap allows experiment participant to hear.It is elegant and tasteful that experiment participant is described as fragrance to the sense organ of the latter,
Body and mind is pleasant, and sensory experience is more preferable than three kinds of front, it is seen that Compositional type deodorant tune can assign the salubriouser pleasure of this hand cleanser
Fragrance.
(4) inoxidizability is tested: the antibacterial skin-whitening liquid soap of embodiment 1, embodiment 8 and embodiment 9 is put into 50 degree of perseverances
In warm baking oven, opening heat preservation 48 hours observes sample discoloration, as a result see the table below 3.
Table 3: antibacterial skin-whitening liquid soap inoxidizability experimental result
| Embodiment | Tea polyphenols: phytic acid=1:1 | Tea polyphenols | Phytic acid |
| 1 | Do not change | / | / |
| 8 | / | Discoloration, it is light yellow | / |
| 9 | / | / | Discoloration, buff |
As it can be seen that the present invention is used in compounding using tea polyphenols and phytic acid, antioxidant effect can protect song better than being used alone
Acid is not oxidized.
A kind of antibacterial skin-whitening liquid soap is present embodiments provided, is calculated by mass percentage, formula includes such as the following group
Point:
Above-mentioned, although specific embodiments of the present invention have been described, not to the limit of the scope of the present invention
System, based on the technical solutions of the present invention, those skilled in the art do not need to make the creative labor can make it is each
Kind modification, replacement or deformation are still within protection scope of the present invention.
Claims (9)
1. a kind of antibacterial skin-whitening liquid soap, which is characterized in that be calculated by mass percentage, formula includes following component:
2. antibacterial skin-whitening liquid soap according to claim 1, which is characterized in that the quality percentage of the kojic acid and its derivative
Than being 0.5~1.5%.
3. antibacterial skin-whitening liquid soap according to claim 1 or claim 2, which is characterized in that the derivative of kojic acid is two palm fibre of kojic acid
Glycerin monostearate, kojic acid methylene umbellic acid ester, kojic acid amino acid derivativges, kojic acid ether derivant, kojic acid list double acid ester
One of derivative is a variety of.
4. antibacterial skin-whitening liquid soap according to claim 1, which is characterized in that the fluorocarbon surfactant is perfluoroalkyl
One of polyethers, perfluoralkyl phosphate, perfluoroalkyl betain are a variety of.
5. antibacterial skin-whitening liquid soap according to claim 1, which is characterized in that the nonionic surfactant is coconut oil
Fatty diglycollic amide or alkyl-glucoside.
6. antibacterial skin-whitening liquid soap according to claim 1, which is characterized in that the amphoteric surfactant is cocounut oil propyl
Glycine betaine, lauroylamidopropyl betaine, dodecyl ethyoxyl sulfobetaines, dodecyl hydroxypropyl sulfobetaines,
One of dodecyl azochlorosulfonate propyl lycine, myristamide propyl hydroxypropyl sulfobetaines are a variety of.
7. antibacterial skin-whitening liquid soap according to claim 1, which is characterized in that the cationic surfactant is the tetradecane
One of ylmethyl dihydroxy ethyl ammonium bromide, cetyl trimethylammonium bromide, octadecyltrimethylammonium chloride are a variety of.
8. antibacterial skin-whitening liquid soap according to claim 1, which is characterized in that the Compositional type antioxidant be tea polyphenols and
Phytic acid is compounded according to mass ratio 1:1.
9. antibacterial skin-whitening liquid soap according to claim 1, which is characterized in that the Compositional type deodorant tune be flavoring pineapple essence,
Lemon extract, lavender oil are compounded according to mass ratio 1:1:1.
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