CN109568173B - Collagen nano instant mask with hyaluronic acid as skeleton and preparation method thereof - Google Patents
Collagen nano instant mask with hyaluronic acid as skeleton and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a collagen nano instant mask taking hyaluronic acid as a skeleton and a preparation method thereof, the mask comprises a non-woven fabric substrate layer and a nanofiber layer, wherein the nanofiber layer is formed on the non-woven fabric substrate layer by adopting an electrostatic spinning method, and the nanofiber layer comprises: 10-35 parts by weight of sodium hyaluronate, 6-50 parts by weight of hydrolyzed collagen and 0.1-5 parts by weight of surface active substance; wherein the average molecular weight of the sodium hyaluronate is 20000-60000, and the average molecular weight of the hydrolyzed collagen is 1000-3000; the mass ratio of the used sodium hyaluronate to the used hydrolyzed collagen is 1: 5 to 6: 1.
Description
Technical Field
The invention relates to a facial mask and a preparation method thereof, in particular to a collagen nano instant facial mask taking hyaluronic acid as a skeleton and a preparation method thereof.
Background
In the cosmetic market, the facial mask products for personal care mostly adopt a mode of supporting essence on non-woven fabrics, but the products have the defects of easy loss of essence, inconvenient use, low utilization degree, long use time and the like when in use, and meanwhile, the active substances in the facial masks have uncertain transdermal absorption capacity and have the defects of changeability and difficult storage of the active substances. People are constantly developing new facial masks to meet the ever-changing consumer demands of the market.
For example, chinese patent 201310366143.X discloses a composite nanofiber membrane, a preparation method and applications thereof, which includes the steps of: (1) dissolving any one of polyvinyl alcohol, polylactic acid and regenerated silk fibroin in an organic solvent to prepare spinning solution with the mass fraction of 5-20%; (2) adding a polyphenol substance into the spinning solution, and uniformly stirring to obtain a mixed spinning solution which accounts for 1-7% of the total mass of the polyphenol substance and the organic solvent, wherein the polyphenol substance is one or more of plant tannin, apple polyphenol and grape polyphenol; (3) carrying out ultrasonic treatment on the mixed spinning solution for 1-600 min; (4) and (3) carrying out electrostatic spinning on the mixed spinning solution, and collecting to obtain the required composite nanofiber membrane. However, the spinning solution of the patent is prepared by an organic solvent, which brings more environmental protection problems.
Chinese patent application 201310403704.9 discloses a nanofiber whitening and spot removing mask patch, which comprises a spinning solution and cotton cloth, wherein the active ingredient of the spinning solution is reduced glutathione and an antioxidant adjuvant, and the mass ratio of the active ingredient is reduced glutathione: antioxidant auxiliary materials are 1-10. The effective components for whitening and removing freckles are reduced Glutathione (GSH) and antioxidant auxiliary materials, wherein the GSH is dispersed in nano-fibers in a form of nano-particles, and the antioxidant auxiliary materials can maintain the active group sulfhydryl (-SH) in the GSH in a reduction state. The polymer forming the nanofibers is preferably one or more of polyvinyl alcohol, polyvinyl pyrrolidone, water-soluble chitosan, polyoxyethylene, wheat protein, starch, gelatin, and hyaluronic acid, and the solvent used is preferably one or more of formic acid, acetic acid, acetone, methanol, ethanol, dichloromethane, chloroform, dimethylformamide, tetrahydrofuran, trifluoroacetic acid, and hexafluoro-2-propanol. Likewise, water is the most environmentally friendly and cost effective solvent compared to organic or other non-polar solvents, but organic solvents are preferred.
Chinese patent application 201510684960.9 discloses a collagen anti-aging mask, which comprises a collagen mask substrate, a peeling layer, and an anti-aging essence immersion liquid, wherein the collagen mask substrate is prepared by the following method: (1) dispersing the freeze-dried collagen powder in a solution to prepare a polymer solution, wherein the temperature and the humidity of the polymer solution are both indoor conditions; (2) by an electrostatic spinning method, the prepared polymer solution is uniformly distributed with collagen on one side of the nanofiber layer through an injection head under the action of static electricity; (3) placing the collagen fiber layer in the step (2) in a dryer filled with steam generated by 25% glutaraldehyde water solution in mass fraction for 12-24h to enable the collagen and the nanofiber layer to generate cross-linking reaction and mutually laminate; (4) the unreacted glutaraldehyde in the sample was removed with glycine, and the laminate was cut at positions corresponding to the nose, mouth and eyes, with the contour of the face contoured. However, the facial mask of the application still belongs to a wet facial mask and is inconvenient to use.
Chinese patent application 201810371233.0 discloses a so-called wash-free full-absorption nanofiber functional facial mask and a preparation method thereof, wherein the facial mask comprises the following components in parts by weight: 5 to 50 percent of polysaccharide, modified polysaccharide and water-soluble polymer, 1 to 10 percent of polymer with whitening effect, 0.001 to 5 percent of functional substance, 0.02 to 2 percent of essence and the balance of water. The nanofiber functional facial mask disclosed by the patent is produced in batch by using an electrostatic spinning technology and taking water-soluble modified polysaccharide or high polymer as a main solute and various functional substances as additives. However, although the application generally mentions that the polysaccharide, the modified polysaccharide and the water-soluble polymer are one or more of gelatin, bone glue, carrageenan, carboxymethyl cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, sodium hyaluronate, sodium alginate, polyethylene glycol and polyacrylamide, the application does not disclose how to use these substances, and the phenomena of conglomeration, knots, broken filaments, holes and the like are very easy to occur in electrostatic spinning, thereby seriously affecting the performance of the mask. The examples of this patent application are only mentioned "adding 5 to 50 mass% of polysaccharides, modified polysaccharides, water-soluble polymers such as polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and the like to water, respectively".
Chinese patent application 201810053724.0 discloses a preparation method of a nanofiber-based dry facial mask, which comprises the preparation of a polyvinyl alcohol aqueous solution, a chitosan aqueous solution, a sodium hyaluronate solution and a nutrient solution; mixing the prepared product as a spinning solution to perform multi-needle electrostatic spinning, using a non-woven fabric substrate for a mask as a receiving screen, and finally forming a layer of nanofiber membrane on the non-woven fabric substrate of the mask to prepare a composite fiber membrane; drying at 70-80 deg.C for 2-5 min; cutting, shaping, sealing, packaging and sterilizing to obtain the dry facial mask. The active ingredients in the mask liquid are mixed into the polyvinyl alcohol spinning base liquid, the nanofiber is prepared by an electrostatic spinning technology and is fixed on the mask non-woven fabric, the mask is taken out when the mask liquid is used, and a proper amount of purified water is sprayed on the front surface of the mask liquid, so that the mask can be fully wetted and applied.
Chinese patent application 201811020688.4 discloses a preparation method of a solid mask, which comprises brushing aqueous gel on non-woven fabric, baking the non-woven fabric, uniformly coating active ingredients on the non-woven fabric through an electrostatic spraying gun, wherein the weight of the active ingredients adsorbed by each gram of non-woven fabric is 0.01-0.3 g, and finally cutting the treated non-woven fabric into the mask according to human faces.
However, when the nanofiber is prepared by using electrostatic spinning in the prior art, on one hand, the formed nanofiber is prone to have the phenomena of agglomeration, knots, broken filaments, holes and the like, the structure of the nanofiber is seriously influenced, and the care performance of the mask is reduced, on the other hand, the nutritional ingredients added in the spinning solution often influence the formation of the spinning fiber, and the solvent selection of the spinning solution also often neglects the environmental protection problem.
Accordingly, there is a need for a novel dry mask that overcomes the disadvantages and drawbacks of the prior art.
Disclosure of Invention
The invention aims to provide a dry facial mask with uniformly distributed nano-fibers and without using an organic solvent and a preparation method thereof, and a nano-fiber layer in the facial mask can be quickly dissolved to play a role.
In one aspect, in order to achieve the above object, the present invention provides a collagen nano instant facial mask with hyaluronic acid as a skeleton, the facial mask includes a non-woven fabric substrate layer and a nanofiber layer, wherein the nanofiber layer is formed on the non-woven fabric substrate layer by an electrostatic spinning method, and the nanofiber layer includes:
1-30 parts by weight of sodium hyaluronate
5-50 parts by weight of hydrolyzed collagen; and
0.1 to 5 parts by weight of a surface-active substance;
wherein the average molecular weight of the sodium hyaluronate is between 30000 and 60000, preferably between 25000 and 50000; the average molecular weight of the hydrolyzed collagen used is between 1000-; and the mass ratio of the used sodium hyaluronate to the used hydrolyzed collagen is 1: 5 to 6: 1, preferably between 1: 3 to 3: 1.
Preferably, the nanofiber layer of the mask includes:
3-20 parts by weight of sodium hyaluronate
6-30 parts by weight of hydrolyzed collagen; and
0.5-3 parts by weight of a surface active substance.
In the facial mask, the sodium hyaluronate not only forms the skeleton of the nanofiber, but also has skin care activity; the hydrolyzed collagen is low molecular weight hydrolyzed collagen, and has the main function of serving as a skin care active substance; the activity of skin care of the hydrolyzed collagen with low molecular weight is far higher than that of the hydrolyzed collagen with high molecular weight. Of course, too low molecular weight hydrolyzed collagen will affect electrospinning.
In the above-mentioned mask, the main function of the surface active substance used is to reduce the surface tension, and any surfactant is not suitable for the present invention; the surface-active substances according to the invention should be water-soluble, have no adverse effect on the skin care and should not interfere with the electrospinning to form uniform fibers. That is, in the present invention, any surface active material that is water-soluble, has a certain skin care effect, and facilitates electrospinning can be used in the present invention.
Specifically, in the mask pack of the present invention, the surface active substances used may be: polyoxyethylene sorbitol ester type emulsifiers such as polysorbate-20, polysorbate-60, polysorbate-80 and the like; sucrose ester emulsifiers such as sucrose laurate, sucrose stearate; polyglycerin-based emulsifiers such as polyglycerin-10 myristate, polyglycerin-6 caprylate, polyglycerin-6 stearate, and the like; glycoside emulsifiers such as coco glucoside, lauryl glucoside, and the like; polyether or polyether ester emulsifiers such as PEG-40 hydrogenated castor oil, PEG-20 methylgluco-sesquistearate, etc.; and so on.
The electrostatic spinning technology adopted by the invention is a construction technology that a polymer solution overcomes surface tension under the action of high-voltage static electricity, forms a Taylor (Taylor) cone at a spinning nozzle, jets out jet flow at high speed, and is solidified to form a nanofiber structure through mechanical stretching and solvent volatilization.
The nanofiber layer in the facial mask is a layered object which is manufactured by using water-soluble polymers such as sodium hyaluronate and the like as a matrix through an electrostatic spinning technology and is formed by fibers with the diameter of only hundreds of nanometers, and the facial mask has the advantages of large specific surface area, good fiber continuity, small fiber membrane pore size, high porosity and the like, has good effects of slow release and protection of active substances, is easy to permeate the stratum corneum of the skin to reach the deep layer of the skin, and has the functions of moisturizing, whitening, aging delaying and the like.
The facial mask is a dry facial mask, is easy to carry and store and convenient to use, and when the facial mask is used, the skin is firstly moistened by products such as purified water or spray, and then the nano instant facial mask is applied, so that the nano facial mask is completely dissolved within a few seconds and is applied to the skin to play a role, and the facial mask does not need to be cleaned after being used, and can keep the skin tight for hours and keep the humidity.
In order to form uniform spinning and prevent the occurrence of a lumping phenomenon during the electrospinning process, it is preferable that the nanofiber layer thereof further comprises, in the mask pack of the present invention: 0.1 to 20 parts by weight of maltooligosaccharide glucoside and 0.1 to 15 parts by weight of hydrogenated starch hydrolysate, preferably 2 to 10 parts by weight of maltooligosaccharide glucoside and 1 to 6 parts by weight of hydrogenated starch hydrolysate. In addition, the use of maltooligosaccharide glucoside and hydrogenated starch hydrolysate improves the user's use of the mask of the present invention, which prevents the rubbing phenomenon on the face. In the nanofiber layer of the mask of the present invention, if the ratio of maltooligosaccharide glucoside to hydrogenated starch hydrolysate used is too low, for example, less than 0.1 part by weight, the above-mentioned improvement effect is not significant, but if the ratio is too large, for example, maltooligosaccharide glucoside exceeds 30 parts by weight and/or hydrogenated starch hydrolysate exceeds 20 parts by weight, the spinning performance is adversely affected, for example, the fiber strength is too low, the skin care effect is reduced, and the like.
Preferably, in the mask pack of the present invention, the nanofiber layer further comprises: 0.1 to 5 parts by weight of polyethylene glycol having a high degree of polymerization and 0.1 to 10 parts by weight of polyethylene glycol having a low degree of polymerization, preferably 0.5 to 2 parts by weight of polyethylene glycol having a high degree of polymerization and 0.5 to 5 parts by weight of polyethylene glycol having a low degree of polymerization; wherein the average molecular weight of the polyethylene glycol with high polymerization degree is 250000-350000, and the average molecular weight of the polyethylene glycol with low polymerization degree is 6000-10000.
The polyethylene glycol with high polymerization degree can increase the tenacity of the fiber, so that the spinning becomes relatively easy and the spinning is uniform; the polyethylene glycol with low polymerization degree can further prevent the agglomeration phenomenon in the electrostatic spinning process and promote the formation of uniform spinning.
Preferably, in the mask pack of the present invention, the low-polymerization-degree polyethylene glycol used has an average molecular weight of between 7000 and 9000; more preferably, the polyethylene glycol of low degree of polymerization used has an average molecular weight of between 7600 and 8600.
As a specific embodiment of the present invention, in the mask pack of the present invention, the nanofiber layer comprises:
3-20 parts by weight of sodium hyaluronate
6-25 parts by weight of hydrolyzed collagen
0.5-6 parts by weight of maltooligosaccharide glucoside
0.5-4 parts by weight of hydrogenated starch hydrolysate
0.1-3 parts by weight of polyethylene glycol with high polymerization degree
0.1 to 6 parts by weight of polyethylene glycol having a low degree of polymerization; and
0.1-2 parts by weight of a surface-active substance.
As another embodiment of the present invention, in the mask pack of the present invention, the nanofiber layer comprises:
5-20 parts by weight of sodium hyaluronate
10-25 parts by weight of hydrolyzed collagen
1.0-3 parts by weight of maltooligosaccharide glucoside
0.8-2 parts by weight of hydrogenated starch hydrolysate
0.5-3 parts by weight of polyethylene glycol with high polymerization degree
0.5 to 8 parts by weight of polyethylene glycol having a low degree of polymerization; and
0.1-0.8 parts by weight of surface active substance.
In the mask pack of the present invention, a peelable protective layer may be further included on the nanofiber layer. In the product design, the final product has three layers, the non-woven fabric is taken as a substrate, electrostatic spinning is carried out on the non-woven fabric substrate, the filaments formed by electrostatic spinning are the middle layer (nanofiber layer), the outer layer is also provided with a coating film, the film can be a PE film or a BOPP film, but static electricity needs to be removed. When the product is used, the fiber layer is not required to be stripped, and the product can be used only by uncovering the coating film on the outer surface; the product can be mixed with nutrient solution or not, and consumers can use the product only by spraying pure water on the face.
Further, in the mask pack of the present invention, the nanofiber layer may include 0.001-2 parts by weight of a functional substance, such as a preservative, e.g., pentasodium penta-pentetate, phytic acid, silver oxide, etc., or other skin care agents, etc.
In addition, in order to reduce the cost of the mask of the present invention, pullulanase polysaccharide (pullulan) may be used in place of a part of sodium hyaluronate, and the resulting mask still has excellent properties. For example, the nanofiber layer of the mask of the present invention comprises:
5-10 parts by weight of sodium hyaluronate
5-25 parts by weight of pullulanase polysaccharide
6-50 parts by weight of hydrolyzed collagen; and
0.1 to 5 parts by weight of a surface-active substance;
wherein the average molecular weight of the pullulanase is between 100000-300000, preferably between 150000-250000. Or the nanofiber layer of the mask of the present invention comprises:
5-10 parts by weight of sodium hyaluronate
5-10 parts by weight of pullulanase polysaccharide
6-30 parts by weight of hydrolyzed collagen; and
0.5-3 parts by weight of a surface active substance.
In another aspect, to achieve the object of the present invention, the present invention also provides a method for preparing the above mask, wherein the method comprises the steps of:
(1) and preparing a spinning solution: adding sodium hyaluronate, hydrolyzed collagen and surface active substances into purified water serving as a solvent, and stirring to form uniform spinning solution, wherein the spinning solution comprises 1-30 wt% of sodium hyaluronate, 5-50 wt% of hydrolyzed collagen and 0.1-5 wt% of surface active substances;
(2) and electrostatic spinning: adding the prepared spinning solution into electrostatic spinning equipment, and carrying out electrostatic spinning by taking non-woven fabrics as a receiving base material;
wherein, the average molecular weight of the used sodium hyaluronate is between 30000-60000, and the average molecular weight of the used hydrolyzed collagen is between 1000-3000.
Further, in the above preparation method, the spinning dope further comprises 0.1 to 20 wt% of maltooligosaccharide glucoside and 0.1 to 15 wt% of hydrogenated starch hydrolysate;
preferably, the spinning solution further contains 0.1-3 wt% of polyethylene glycol with high polymerization degree and 0.1-10 wt% of polyethylene glycol with low polymerization degree, wherein the average molecular weight of the polyethylene glycol with high polymerization degree is 250000-350000, and the average molecular weight of the polyethylene glycol with low polymerization degree is 6000-10000.
The electrostatic spinning equipment used in the preparation process can adopt roller-type needle-free electrostatic spinning equipment, and the equipment has the characteristics of large spinning quantity, high production efficiency and uniform spinning.
Experimental observation of a scanning electron microscope proves that the nanofiber layer of the facial mask is very uniform, and the facial mask has no defects of agglomeration, nodes, broken filaments, holes and the like, ensures uniform distribution of active substances, and has high utilization efficiency and no dead angle in skin care; therefore, the arrangement mode that the formed fiber structure is close to skin cells is ensured, and the nursing effect is more favorably and fully exerted.
The mask of the invention is a dry mask, which is convenient for carrying and storage; the facial mask is also a nano instant facial mask, when in use, the skin is firstly moistened by using products such as purified water or spray, and then the facial mask is applied, so that the nano facial mask is completely dissolved within a few seconds; experimental observation of a facial image analyzer proves that the facial mask disclosed by the invention has an obvious wrinkle removing effect.
The present invention will be further described with reference to the accompanying drawings and specific embodiments, which are illustrative of certain specific embodiments of the present invention and are not to be construed as limiting the invention.
Drawings
FIGS. 1-4 are scanning electron micrographs of electrospun nanofibers formed in the mask of the present invention, wherein the fibers shown in FIGS. 1-2 have an average diameter of 0.21 μm and the fibers shown in FIGS. 3-4 have an average diameter of 0.17 μm;
FIG. 5 is a comparison of the front and back whole face of a mask of the present invention, wherein the left image is before use and the right image is after use;
FIG. 6 is a comparison of the front and rear partial faces of a face mask using the present invention, wherein the left image is before use and the right image is after use;
fig. 7 is a comparison of the pouch position before and after using the mask of the present invention, wherein the left is before use and the right is after use.
Detailed description of the preferred embodiments
Example 1
The mask of the present invention is prepared as follows:
(1) preparing a spinning solution: adding sodium hyaluronate, hydrolyzed collagen, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, PEG-7M, PEG-180, polyglycerol-10 myristate and preservative into pure water serving as a solvent, and stirring in a constant-temperature water bath at 20-50 ℃ for 2-6 hours until the solution is uniform and free of particles to obtain a spinning solution containing the following components: 10 wt% of sodium hyaluronate, 5 wt% of hydrolyzed collagen, 2 wt% of maltooligosaccharide glucoside, 1 wt% of hydrogenated starch hydrolysate, 2 wt% of PEG-7M (PEG with high polymerization degree), 2 wt% of PEG-180 (PEG with low polymerization degree), 1 wt% of polyglycerol-10 myristate, and 0.2 wt% of preservative, wherein the average molecular weight of the sodium hyaluronate used is about 30000, the average molecular weight of the hydrolyzed collagen used is about 2000, the average molecular weight of the PEG-7M used is about 300000, the average molecular weight of the PEG-180 used is about 8000, and the preservative used is pentetate, phytic acid, and silver oxide;
(2) and electrostatic spinning: pouring the prepared uniform solution into a trough of electrostatic spinning equipment, controlling the humidity of a spinning environment to be 30-50%, the spinning distance to be 140-220 mm, the spinning voltage to be 40-85 KV, the spinning speed to be 0.1-1.2 r/min and the current to be 0.2-1.5mA, and carrying out electrostatic spinning by taking non-woven fabrics as a receiving base material.
Example 2
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 15 wt% of sodium hyaluronate, 3 wt% of hydrolyzed collagen, 0.5 wt% of maltooligosaccharide glucoside, 0.5 wt% of hydrogenated starch hydrolysate, 0.5 wt% of PEG with high polymerization degree, 5 wt% of PEG with low polymerization degree, 5.0 wt% of polysorbate-20 and 0.1 wt% of preservative, wherein the average molecular weight of the sodium hyaluronate is about 25000, the average molecular weight of the hydrolyzed collagen is about 1200, the average molecular weight of the PEG with high polymerization degree is about 250000, and the average molecular weight of the PEG with low polymerization degree is about 10000.
Example 3
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 5 wt% of sodium hyaluronate, 30 wt% of hydrolyzed collagen, 5 wt% of maltooligosaccharide glucoside, 3 wt% of hydrogenated starch hydrolysate, 1 wt% of high polymerization degree PEG, 2 wt% of low polymerization degree PEG, 0.2 wt% of sucrose laurate and 2.0 wt% of preservative, wherein the average molecular weight of the sodium hyaluronate used is about 50000, the average molecular weight of the hydrolyzed collagen used is about 3000, the average molecular weight of the high polymerization degree PEG used is about 350000, and the average molecular weight of the low polymerization degree PEG used is about 9000.
Example 4
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 3 wt% of sodium hyaluronate, 6 wt% of hydrolyzed collagen, 20 wt% of maltooligosaccharide glucoside, 10 wt% of hydrogenated starch hydrolysate, 1.5 wt% of PEG with high polymerization degree, 10 wt% of PEG with low polymerization degree, 3 wt% of coco glucoside and 1.0 wt% of preservative, wherein the average molecular weight of the sodium hyaluronate is about 55000 and 60000, the average molecular weight of the hydrolyzed collagen is about 2600, the average molecular weight of the PEG with high polymerization degree is about 280000, and the average molecular weight of the PEG with low polymerization degree is about 7000.
Example 5
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 2 wt% of sodium hyaluronate, 9 wt% of hydrolyzed collagen, 10 wt% of maltooligosaccharide glucoside, 15 wt% of hydrogenated starch hydrolysate, 2 wt% of high polymerization degree PEG, 1 wt% of low polymerization degree PEG, 1.5 wt% of PEG-40 hydrogenated castor oil and 0.5 wt% of preservative, wherein the average molecular weight of the sodium hyaluronate is about 40000, the average molecular weight of the hydrolyzed collagen is 2300, the average molecular weight of the high polymerization degree PEG is 320000, and the average molecular weight of the low polymerization degree PEG is 7600.
Example 6
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 8 wt% of sodium hyaluronate, 15 wt% of hydrolyzed collagen, 6 wt% of maltooligosaccharide glucoside, 3 wt% of hydrogenated starch hydrolysate, 0.8 wt% of high polymerization degree PEG, 0.3 wt% of low polymerization degree PEG, 1.8 wt% of polyglycerol-6 caprylate, and 0.3 wt% of preservative, wherein the average molecular weight of the sodium hyaluronate used is about 33000, the average molecular weight of the hydrolyzed collagen used is about 2100, the average molecular weight of the high polymerization degree PEG used is about 330000, and the average molecular weight of the low polymerization degree PEG used is about 7800.
Example 7
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 12 wt% of sodium hyaluronate, 8 wt% of hydrolyzed collagen and 1.2 wt% of polyglycerol-6 caprylate, wherein the average molecular weight of the sodium hyaluronate is about 36000, and the average molecular weight of the hydrolyzed collagen is about 1900.
Example 8
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 8 wt% of sodium hyaluronate, 12 wt% of hydrolyzed collagen, 3 wt% of maltooligosaccharide glucoside, 2 wt% of hydrogenated starch hydrolysate, 0.8 wt% of polyglycerol-6 caprylate and 0.1 wt% of preservative, wherein the average molecular weight of the sodium hyaluronate is about 39000 and the average molecular weight of the hydrolyzed collagen is about 2300.
Example 9
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 10 wt% of sodium hyaluronate, 10 wt% of hydrolyzed collagen, 1.2 wt% of PEG with high polymerization degree, 5.3 wt% of PEG with low polymerization degree and 1.8 wt% of polyglycerol-6 caprylate, wherein the average molecular weight of the sodium hyaluronate is about 43000, the average molecular weight of the hydrolyzed collagen is about 2000, the average molecular weight of the PEG with high polymerization degree is 230000, and the average molecular weight of the PEG with low polymerization degree is 7500.
Example 10
A mask was prepared in the same procedure and manner as in example 1, except that the prepared dope contained the following components: 3 wt% of sodium hyaluronate, 10 wt% of hydrolyzed collagen, 10 wt% of pullulanase polysaccharide, 0.5 wt% of PEG with high polymerization degree, 5.3 wt% of PEG with low polymerization degree and 1.8 wt% of polyglycerol-6 caprylate, wherein the average molecular weight of the sodium hyaluronate is about 41000, the average molecular weight of the hydrolyzed collagen is about 2000, the average molecular weight of the PEG with high polymerization degree is about 230000, the average molecular weight of the PEG with low polymerization degree is about 7500, and the average molecular weight of the pullulanase polysaccharide is about 200000.
Example 11
The mask was prepared in the same procedure and manner as in example 1, but it was further subjected to a step of forming a peelable protective layer of PE film on top of the spun yarn (nanofiber layer) and removing static electricity. That is, the final face film has three layers, a nonwoven fabric is used as a backing, electrospinning is spun on the nonwoven fabric backing, and the filaments formed by electrospinning are the middle layer (nanofiber layer). A product package may contain several masks, and the package may be equipped with a container for a nutritional liquid, such as a small sprayer.
Electron microscope experiment and facial image analysis experiment
Observing the nanofiber layer formed by electrostatic spinning by using a scanning electron microscope, it can be clearly seen that the formed fibers are relatively uniform and do not have any agglomeration, caking, knots, breakpoints and cavities, please refer to fig. 1-4; the fiber average diameter formed is generally between 0.10 μm and 0.30 μm; wherein the average diameter of the fibers shown in FIGS. 1-2 is 0.21. mu.m, and the average diameter of the fibers shown in FIGS. 3-4 is 0.17. mu.m.
The skin of a user who used the mask of the present invention before and after use was analyzed using a facial image analyzer VISIA-CR of Manfield corporation, usa, and the results are shown in fig. 5 to 7. Wherein, fig. 5 is a comparison graph of the whole face before and after using the facial mask of the invention, wherein, the left graph is before use, and the right graph is after use; FIG. 6 is a comparison of the front and rear partial faces of a face mask using the present invention, wherein the left image is before use and the right image is after use; fig. 7 is a comparison of the pouch position before and after using the mask of the present invention, wherein the left is before use and the right is after use. FIG. 5 shows that the L value of the face is 84.95353 before use of the mask and 85.31294 after use of the mask, which illuminates the person more; fig. 6 shows that the ratio of wrinkles in the selected area was 16.45% before the mask was used, and 13.38% after the mask was used, and the wrinkle removal effect was significant after the mask was used; fig. 7 shows that the wrinkle ratio in the selected pouch region was 18.84% before the mask was used, 15.33% after the mask was used, and the wrinkle removing effect on the pouch was more remarkable after the mask was used.
Claims (7)
1. The collagen nano instant facial mask comprises a non-woven fabric base material layer and a nanofiber layer, wherein the nanofiber layer is formed on the non-woven fabric base material layer by adopting an electrostatic spinning method, and the nanofiber layer comprises:
3-20 parts by weight of sodium hyaluronate;
10-25 parts by weight of hydrolyzed collagen;
0.5-6 parts by weight of maltooligosaccharide glucoside;
0.5-4 parts by weight of a hydrogenated starch hydrolysate;
0.1-3 parts by weight of polyethylene glycol having a high degree of polymerization;
0.1 to 6 parts by weight of polyethylene glycol having a low degree of polymerization; and 0.1-2 parts by weight of a surface active substance;
wherein the average molecular weight of the sodium hyaluronate is 20000-60000, and the average molecular weight of the hydrolyzed collagen is 1000-3000;
the mass ratio of the sodium hyaluronate to the hydrolyzed collagen is 1: 5 to 6: 1;
the average molecular weight of the polyethylene glycol with high polymerization degree is 250000-350000, and the average molecular weight of the polyethylene glycol with low polymerization degree is 6000-10000;
wherein the surface active substance is polyglycerol-10 myristate.
2. The mask as claimed in claim 1, wherein the mass ratio of the sodium hyaluronate to the hydrolyzed collagen is in the range of 1: 3 to 3: 1.
3. The mask pack of any one of claims 1-2, wherein the nanofiber layer further comprises:
5-25 parts by weight of pullulanase; wherein the average molecular weight of the pullulanase is 100000-300000.
4. The mask as claimed in claim 3, wherein the pullulanase has an average molecular weight of between 150000 and 250000.
5. The mask pack of claim 1, wherein the mask pack further comprises a peelable protective layer over the nanofiber layer.
6. The mask pack according to claim 1, wherein the nanofiber layer further comprises 0.001-2 parts by weight of a functional material.
7. A method of preparing the mask pack of claim 1, wherein the method comprises the steps of:
(1) preparing a spinning solution: adding sodium hyaluronate, hydrolyzed collagen, polyglycerol-10 myristate, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, polyethylene glycol with high polymerization degree and polyethylene glycol with low polymerization degree into purified water serving as a solvent, and stirring to form uniform spinning solution, wherein the spinning solution comprises 3-20 parts by weight of sodium hyaluronate, 0.5-6 parts by weight of maltooligosaccharide glucoside, 0.5-4 parts by weight of hydrogenated starch hydrolysate, 10-25 parts by weight of hydrolyzed collagen, 0.1-3 parts by weight of polyethylene glycol with high polymerization degree, 0.1-6 parts by weight of polyethylene glycol with low polymerization degree and 0.1-2 parts by weight of polyglycerol-10 myristate;
(2) electrostatic spinning: adding the prepared spinning solution into electrostatic spinning equipment, and carrying out electrostatic spinning by taking non-woven fabrics as a receiving base material;
wherein the average molecular weight of the sodium hyaluronate is 30000-60000.
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| CN110664619A (en) * | 2019-10-30 | 2020-01-10 | 诺斯贝尔化妆品股份有限公司 | Collagen nano instant mask of yeast recombinant collagen and preparation method thereof |
| IT202000002836A1 (en) * | 2020-02-13 | 2021-08-13 | Bakel S R L | COSMETIC PRODUCT |
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| CN115305590A (en) * | 2021-12-30 | 2022-11-08 | 希纤新材料(广州)有限公司 | Composite fiber for mask base cloth and preparation method thereof |
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