CN1095615A

CN1095615A - Externally-used agent for treatment of psoriasis

Info

Publication number: CN1095615A
Application number: CN 93118088
Authority: CN
Inventors: 卢兰亭; 卢云飞; 任智勇
Original assignee: 卢兰亭
Priority date: 1993-09-30
Filing date: 1993-09-30
Publication date: 1994-11-30

Abstract

What the present invention relates to is a kind of medicine that is used for the treatment of refractory skins such as psoriasis.Its basic effective constituents is: Chinese and Western medical materials such as Radix Panacis Quinquefolii, hydrocortisone, Calomelas, Os Draconis, Calamina, salicylic acid, sulfur, phenol, with their powder and substrate, make various external agent products.The present invention offers medicine simply, fills a prescription unique, makes easily; Good effect, safe and reliable, have no side effect effective percentage 100%, cure rate is more than 90%, and the scope of application is wide, good economy performance, whatsoever this preparation of psoriasis of type all has good effectiveness, can alleviate significantly the patient pain and if financial burden, obvious social benefit.

Description

Externally-used agent for treatment of psoriasis

What the present invention relates to is a kind of medicine that is used for the treatment of refractory skins such as psoriasis.

Psoriasis is one of four big pertinacious diseases of being known as world's end solution still.This refractory skin makes the patient taste varieties of misery, extremely decocts torment.Be used for the treatment of the effective medicine for external use of refractory skin such as psoriasis at present, as anthralin Ointment, chlorine fluorine Shu Shuan etc., generally all formed by substrate and active ingredient modulation, select for use different substrate to can be formulated into different cream, frost (breast) dosage form, chemical substance is almost adopted in active ingredient entirely.The weak point of these existing common drugs mainly is: curative effect is all not ideal enough, easily recurrence after the drug withdrawal, and Western medicine, the side effect of chemicals life-time service are big, and what have contains a large amount of hormones; In addition, also there is narrow application range in the medicine that has, and what have is only effective to certain several types in the psoriasis, not suitable to other type, not only invalid, increases the weight of on the contrary sometimes after the use; Though have effectively curative effect is slow, the course of treatment long, need just can manifest effect more than half a year to one year, these certainly will make patient economy burden overweight.

The objective of the invention is to avoid the deficiencies in the prior art part, and a kind of good effect is provided, short treating period is in having no side effect, the psoriasis external agent product formed of Western medicine.

Can take following technical scheme to realize purpose, it is also formed by substrate and effective ingredient allotment, but active ingredient is made up of Radix Panacis Quinquefolii, hydrocortisone, Calomelas, Os Draconis, Calamina, salicylic acid, sulfur, phenol substantially, and the consumption of every component can be selected as one sees fit.Medical material through clean, dry, pulverization process becomes 80-120 order fine powdered, active ingredient and substrate are mixed in proportion promptly can be made into to the specific various external agent products of refractory skins such as psoriasis.

Be described in further detail in conjunction with the content of embodiment the technical program.

During Chinese and Western medical material in this psoriasis external agent can be pressed, the conventional amount used of doctor trained in Western medicine is selected, or suitably increase and decrease contains the external agent of these basic effective constituents, all has heat clearing away, removing heat from blood, invigorates blood circulation, nourishes blood, the circulation of qi promoting skin moistening; The obvious effect of desensitization antiinflammatory, antipruritic, desquamation, this is the unique distinction of this preparation just.As for substrate, can adopt vaseline or ethanol or edible oil or Mel or paraffin etc. to make different dosage forms routinely, as cream, water ...Also can mix lanoline in substrate on a small quantity increases the medicine penetration power, play soften, effect such as suction.No matter make which kind of dosage form, basic active ingredient wherein is constant, just refractory skins such as psoriasis is had obvious curative effects.

When the consumption of basic effective constituents is respectively by total weight:

Radix Panacis Quinquefolii 2-3% hydrocortisone 0.1-0.2%

Calomelas 0.1-0.2% Os Draconis 5-20%

Calamina 5-20% salicylic acid 3-5%

Sulfur 3-5% phenol 1-2%;

Made cream during with substrate 50-70% weight, water ..., be good through the clinic trial curative effect.

Also can in above-mentioned effective ingredient, camphorate, Borneolum Syntheticum or other Chinese crude drug adapt to the state of an illness, improves curative effect.Their consumption is Camphora 1-2% by weight, the best during Borneolum Syntheticum 9.8-9.9%.

Used medical material all can be bought from pharmaceuticals or pharmaceutical factory.What wherein Radix Panacis Quinquefolii employing life in 3 years was above is good.The external agent can evenly be coated with one deck by 3 times/day or doctor's advice and get final product in the affected part.

Can prepare psoriasis external agent by the following method:

A, washing: the medical material that will need to wash is removed earth impurity, is cleaned up.To can directly buy, satisfactory powder then need not to carry out other processing.

B, drying: washed medical material is carried out dried, but to degree of grinding.But artificial drying or natural air drying.

C, pulverizing: will be through the pulverizing medicinal materials of above-mentioned processing to the 80-120 order.

D, mixing: due active ingredient and substrate are concerned mix homogeneously in proportion, promptly get psoriasis external agent.Should do different processing routinely to different substrate during mixing, as when adopting vaseline and lanoline,, put after the fusing when being chilled to 40 ℃ of left and right sides earlier with vaseline, lanoline Hybrid Heating as substrate, slowly add each effective ingredient, stirring is psoriasis paster.

Adopt medical general drying plant during preparation, pulverizer, blender, pack, bottle filling machine just can meet the demands, and need not other special installation.

Example 1:(presses % weight)

Radix Panacis Quinquefolii 3

Hydrocortisone 0.2

Calomelas 0.1

Os Draconis 6.8

Calamina 5

Salicylic acid 4

Sulfur 5

Phenol 1

Camphora 1

Borneolum Syntheticum 9.8

70% ethanol 64.1

The water preparation that makes except that to each parapsoriasis effectively, to controlling the head psoriasis specially good effect is arranged.

Example 2:(presses % weight)

Radix Panacis Quinquefolii 3

Hydrocortisone 0.2

Calomelas 0.2

Os Draconis 6.8

Calamina 10.8

Salicylic acid 5

Sulfur 5

Phenol 1

Vaseline 6.8

The unguentum that makes has specially good effect to the refractory skins of locating beyond the head such as psoriasis.

The relatively existing topical drug of the present invention has following advantage:

1, dispensing is simple, and prescription is unique, the Chinese and Western medicine combination, and take Chinese medicine as main, technology is simple, makes easily.

2, good effect, safe and reliable has no side effect: the fast short treating period of curative effect, and general medication 10-20 days can take effect, and with the same usefulness of psoriasis oral agents, recovery from illness 1-3 month course of treatment can not recurred substantially, effective percentage 100%, cure rate is more than 90%.The patient of more than ten years tries out psoriasis external agent, the recovery from illness in two months of psoriasis oral agents, and not recurrence in 5 years is described as the psoriasis specific drug by the trier so far.

3, wide, the good economy performance of the scope of application: the homeliness type of types such as this external agent is dry to heat in blood, the blood of the traditional Chinese medical science, blood stasis, doctor trained in Western medicine, joint type, pustular type etc., whatsoever this preparation of psoriasis of type all has good effectiveness, can significantly alleviate patient's misery and financial burden, obvious social benefit.

Claims

1, a kind of psoriasis external agent is formed by substrate and effective ingredient allotment, it is characterized in that its basic active ingredient is: Radix Panacis Quinquefolii, hydrocortisone, Calomelas, Os Draconis, Calamina, salicylic acid, sulfur, phenol.

2, psoriasis external agent as claimed in claim 1 is characterized in that it also can camphorate, the Borneolum Syntheticum active ingredient.

3, psoriasis external agent as claimed in claim 1 is characterized in that the consumption of active ingredient is respectively by total weight:

Radix Panacis Quinquefolii 2-3% hydrocortisone 0.1-0.2%

Calomelas 0.1-0.2% Os Draconis 5-20%

Calamina 5-20% salicylic acid 3-5%

Sulfur 3-5% phenol 1-2%

Substrate 50-70% weight.

4, psoriasis external agent as claimed in claim 2 is characterized in that by weight: Camphora 1-2%, Borneolum Syntheticum 9.8-9.9%.

5, as claim 1,2 described psoriasis external agent, it is characterized in that its substrate can adopt vaseline, ethanol, edible oil, Mel, paraffin etc.