CN1052420C - Chinese medicine for curing burn and traumatic wound and its production method - Google Patents
Chinese medicine for curing burn and traumatic wound and its production method Download PDFInfo
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Abstract
The present invention relates to a liquid medicine prepared from Chinese herbal medicines for treating burns and external injury wound surfaces and a preparation method thereof. The liquid medicine contains main components of 12 kinds of traditional Chinese medicines, such as honeysuckle flower, gentian, arnebia root, catechu, giant knotweed rhizome, garden burnet root, coptis, etc. The preparation method comprises the following steps: firstly, obtaining liquid medicine by a water extraction method from 9 kinds of traditional Chinese medicines, such as honeysuckle flower, gentian, arnebia root, giant knotweed rhizome, garden burnet root, coptis, etc.; adding the catechu; extracting the traditional Chinese medicines by alcohol; adding borneol and glycerol; filling the medicine mixture into bottles to obtain the liquid medicine by high temperature disinfection. The liquid medicine can effectively treat small or middle area burn wound surfaces within two degrees and external injuries with wound surfaces, the cure rate reaches more than 95%, and scars are not left after injuries are cured.
Description
The present invention relates to a kind of Chinese medicine and production method thereof for the treatment of burn and traumatic surface.
The above burn of medical science textbook, be meant a kind of because the body injury that effects such as heating power (comprising flame, hot water, steam, deep fat or other various high-temp liquids, gas, solid), radiant, light, electric energy or chemical substance cause, this damage is divided into three degree according to its order of severity, doctor trained in Western medicine is cleaned wound surface (chemical drugs burn with special medicinal liquid clean), reuse anti-microbial type medicine coating or transfusion for elder generation with disinfectant solution to the routine treatment of burn at present.Because the Western medicine cost is higher, treatment time is long, and the patient is big in the cost of treatment overall process, be difficult to implement in a lot of rural samll cities and towns, the generally all necessary skin-grafting of the skin of dark II degree of part or III degree burn at present in addition, allo-skin graft easily causes rejection, the consubstantiality skin-grafting can cause new misery again.
Traditional Chinese medicine also has some reports to burn treating, Chinese patent also discloses some treatment burn medicines especially in recent years, as 92101357.4,93101021.7,93120800.9 but the treatment burn medicine medicine source that has is few, the cost that has is higher, also seldom sees product and sell on medical market.
At present also not having open source literature to report utilizes a kind of Chinese medicine preparation can treat the example of burn, scald and traumatic surface simultaneously.
The purpose of this invention is to provide that a kind of raw material sources are wide, price is low, the production method that can treat the Chinese medicine preparation and this preparation thereof of various burns, traumatic surface simultaneously easy to use, eutherapeutic.
In secular medical practice among the people, the inventor is through groping, observe contrast repeatedly, filter out a kind of medicine that can treat various burns, traumatic surface effectively from tens kinds of Chinese herbal medicine, and the primary raw material and the parts by weight of this medicine are as follows:
Radix Gentianae 6-20 Flos Lonicerae 10-18
Radix Arnebiae (Radix Lithospermi) 8-18 catechu 8-15
Rhizoma Polygoni Cuspidati 12-20 Pseudobulbus Bletillae (Rhizoma Bletillae) 10-18
Radix Sanguisorbae 8-18 Cortex Phellodendri 7-15
Radix Et Rhizoma Rhei 8-16 Rhizoma Coptidis 4-12
Borneolum Syntheticum 0.3-0.8 glycerol 3-10
Antiseptic (sorbic acid or potassium sorbate, sodium benzoate etc.) 0.1-0.3
Above-mentioned Chinese medicine all can be found its another name or Latin from Chinese medicine pharmacopeia or Chinese herbal medicine handbook, and the place of production, function, usage.For understanding drug action mechanism of the present invention, the performance of taking passages each Chinese medicinal ingredients is as follows:
Radix Gentianae, have another name called Radix Gentianae, according to the introduction of Chinese medicine dictionary, has antibiotic detoxification, the detumescence antipyretic effect, but be used for harness the Yellow River gallbladder, encephalitis, hematodiarrhoea, carbuncle sore for oral administration more, also do not have the document introduction to cross the medicine of Radix Gentianae as the external curing burn, the present invention adopts it to cooperate with medicines such as Flos Lonicerae, Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, catechu and plays an important role.
Flos Lonicerae, this is the most frequently used heat and toxic materials clearing away medicine of China's folk tradition, it is not only to heating, laryngopharynx swelling and pain, internal diseases such as toxaemia have better curative effect, the abscess of surgery, rheumatism pyretic arthralgia etc. also there is higher curative effect, also narrated its Main Ingredients and Appearance in the CN92101357.4 Chinese patent as burn medicine.
Radix Arnebiae (Radix Lithospermi) has removing heat from blood and promoting blood circulation, antibacterial action, washes the swollen disease that waits of skin ulcer scabies poison but introduce the Radix Arnebiae (Radix Lithospermi) external on the middle medical book, also can be used for treating diseases such as dermatitis, burn, cold injury, scald.
Catechu claims Catechu again, and it can kill staphylococcus aureus and bacillus pyocyaneus, Bacillus proteus etc., has heat clearing away, hemostasis, analgesic therapy effect, to traumatic hemorrhage, infect certain curative effect is arranged.
Rhizoma Polygoni Cuspidati, polygonaceae plant, China's tradition is also treated venom, burn and scald, nameless sorces with it, and it is selected come out from folk medicine that the inventor makes one of principal agent with Rhizoma Polygoni Cuspidati.
The Pseudobulbus Bletillae (Rhizoma Bletillae) it is reported that having treatment festers not close up for a long time and hinder wound surface and control and scald and the chapped skin effect.
Radix Sanguisorbae can be treated metrorrhagia, bloody dysentery etc., also has clinically to use it for burn and clear infections is hemorrhage, and bacillus pyocyaneus etc. is had inhibitory action, and may command infects and toxemia, and reducing body fluid oozes out, and promotes new skin growth.
Cortex Phellodendri, Radix Et Rhizoma Rhei, Rhizoma Coptidis are clearing away damp-heat, eliminating fire and detoxication medicine, and these several medicines all can have bactericidal action to staphylococcus, Hemolytic streptococcus, bacillus pyocyaneus, and can promote subcutaneous hemorrhage to absorb, and surgical infection is had curative effect preferably.
Borneolum Syntheticum also is surgery, a department of dermatologry medicine commonly used, has the effect of heat radiation pain relieving.
Since the inventor preferred above-mentioned Chinese medicine, scientific compatibility, making in addition, make various medicines play collaborative and antagonism each other, learn from other's strong points to offset one's weaknesses, look after comprehensively, give full play to effect separately, formed the effect for the treatment of burn, scald, chemical burn, light, electric burn and wound, infection simultaneously.
Sketch the production method that the present invention treats burn, wound surface wound medicine is arranged below in conjunction with accompanying drawing:
1. earlier with Flos Lonicerae, Radix Gentianae, Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Radix Sanguisorbae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Phellodendri, Radix Et Rhizoma Rhei, nine kinds of Chinese medicines such as Rhizoma Coptidis are selected, pulverize, decoct 2-3 time with 3-5 times of clear water, each 1-3 hour, merge medicinal liquid, the elimination medicinal residues, be concentrated into then about 2/3 volume, to pulverize again and soak dissolved catechu and add,, reclaim ethanol with circumfluence method then with the ethanol lixiviate of 50-95% with clear water, add Borneolum Syntheticum in the medicinal liquid again, glycerol and antiseptic, divide the vial of packing into then, 102～110 ℃ of sterilizations 10-15 minute, natural cooling, labelled, can dispatch from the factory, this medicinal liquid can be preserved 12-15 month at normal temperatures.
Make ointment if desired, can press 2-5% (weight) starch of medicinal liquid total amount in addition,, be added in the admixing medical solutions, under agitation slowly be heated into paste with low amounts of water furnishing pasty state at the medicinal liquid after adding antiseptic, bottling again, sterilization gets final product.
Below be embodiments of the invention.
Embodiment 1, gets 6 kilograms of Radix Gentianae, 10 kilograms of Flos Loniceraes, 8 kilograms of Radix Arnebiae (Radix Lithospermi)s, 10 kilograms of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 12 kilograms of Rhizoma Polygoni Cuspidati, 15 kilograms of Radix Sanguisorbaes, 10 kilograms of Cortex Phellodendris, 12 kilograms of Radix Et Rhizoma Rhei, 6 kilograms of Rhizoma Coptidis, pulverize back 2 times of weight clear water of adding and boiled 3 hours, pour out medicinal liquid, standby, add 1 times of decocting in water 2 hours again, filter then, merge medicinal liquid, about reconcentration to 2/3 (volume), add again in advance with 12 kilograms of catechu of 20 kilograms of clear water dissolvings, with alcohol-pickled 10-15 hour of 75%, ethanol was reclaimed in the distillation of reuse circumfluence method, adds 0.4 kilogram of Borneolum Syntheticum, 2.3 kilogram glycerol, 0.1 the kilogram potassium sorbate, mix homogeneously is put in the vial in 102～110 ℃ of sterilizations 10 minutes, natural cooling, promptly obtain burn, the wound medicinal liquid, this medicinal liquid time spent can be put into air bottle, and product is called " golden imperial burn-treating liquid (spray) ".
Embodiment 2, get 18 kilograms of Radix Gentianae, 16 kilograms of Flos Loniceraes, 9 kilograms of Radix Arnebiae (Radix Lithospermi)s, 12 kilograms of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 16 kilograms of Rhizoma Polygoni Cuspidati, 8 kilograms of Radix Sanguisorbaes, 12 kilograms of Cortex Phellodendris, 10 kilograms of Radix Et Rhizoma Rhei, 5 kilograms of Rhizoma Coptidis, add 3 times of clear water after the pulverizing and decocted 3 hours, pour out medicinal liquid, again slag is added 2 times of decoctings and boiled 1.5 hours, merge medicinal liquid, be concentrated into 2/3 volume, add 16 kilograms in catechu after the dissolving again, use 90% medical alcohol lixiviate then, the cohobation recovered alcohol, add 0.6 kilogram of Borneolum Syntheticum again, 4.2 kilograms of glycerol, 0.2 kilogram of sodium benzoate, bottling promptly obtains " golden imperial burn-treating liquid 105～112 ℃ of temperature sterilizations.”
Embodiment 3,12 kilograms of extracting honeysuckles, 15 kilograms of Radix Gentianae, 10 kilograms of Radix Arnebiae (Radix Lithospermi)s, 18 kilograms of Rhizoma Polygoni Cuspidati, 8 kilograms of Radix Sanguisorbaes, 8 kilograms of Cortex Phellodendris, 8 kilograms of Radix Et Rhizoma Rhei, 8 kilograms of Rhizoma Coptidis, 14 kilograms of the Pseudobulbus Bletillae (Rhizoma Bletillae)s are pulverized the back and decoct (all boiling with clear water) altogether 3 times with 4 times of water at every turn, collect filtrate then, be concentrated into about 2/3 volume, add 9 kilograms of dissolved catechu, reuse ethanol is pressed the method for embodiment 2 and is extracted recovery, adds 3 kilograms of glycerol then, 0.8 kilogram of Borneolum Syntheticum, 0.2 the kilogram antiseptic, the sterilization of 5 kilograms of starch mediations of reuse post-heating obtains product called after " golden imperial external burn cream ".
The present invention's " golden imperial burn-treating liquid (spray) " clinical experiment report, pharmacodynamics test and toxicity test report:
One, clinical experiment report
The test of treatment burn:
Affiliated Hospital of Guangxi Medical University, Yulin Prefecture, Guangxi hospital, 303 hospitals of the Chinese People's Liberation Army use golden imperial burn-treating liquid to carry out the clinical efficacy checking to 105 routine burn patient wound surface, compare with present specially good effect Western medicine silver sulfadiazine, its treatment and scheme are as follows:
Clinical data
Three groups of cases are totally 105 examples, are at random to select, and major part be the inpatient, and minority be the outpatient, and burn surface area calculates the concentrated rule of Nine of pressing of wound surface, then calculates with palm test as if the wound surface dispersion; Depth of burn is got rid of the standard of including in that do not meet (promptly medication data in accordance with regulations is not congruent) case by three degree quartering unified standard records.Curative effect comparision adopts Self-control method, i.e. treatment is chosen in same patient with matched group, and carry out at area, position that the degree of depth is identical on one's body, to get rid of influence, male 65 examples of this group 105 examples, women 40 examples because of differences such as sex, age, systemic factors, age 3-67 year, average 20.1 years old, burn surface area 1-41%, average 10.73 ± 5.43%, based on shallow II °, the minority case also has part dark II ° and being dispersed in property III ° wound surface.
Medication and observational technique:
(1) administrated method: wound surface cleans as 1/2000 liquor hibitane or 1 ‰ benzalkonium bromide solution with the sterilization medicinal liquid earlier, removes come off epidermis and foreign body, and the gauze libation at an ancient wedding ceremony is done, the treatment group is sprayed with golden imperial burn-treating liquid, every day 5-6 time,, make it obtain subcrustal healing until forming the thick medicine crust of about 0.2mm, if empyema under the crust is arranged, again clean with disinfectant solution, remove pus crusts, again row spray medicine, if there is the wound surface aggressive to infect, then use the wrapping of 1%AgSD cold cream instead.Matched group with the method debridement after, comprise or the 5%AgSD suspension is coated with outward with the 1%AgSD cold cream, once a day.
(2) observation of curative effect:
1. in shallow II ° of two weeks of observation of observing time, observed for 3 weeks for dark II °.
2. observed content and statistical method:
(1) witness relatively: A, wound surface area change (pressing the % record); B. the wound surface pus change (keep the score by do not have, less, more, how to remember 0,2,4,6 fen respectively); C. the wound pain degree change (keep the score: by do not have, light, in, remember 0,2,4,6 fen heavily respectively); D. wound healing time (by the sky), more than the difference before and after the record treatment respectively.
(2) treatment group and the more i.e. healing of matched group curative effect, produce effects, effective, invalid 4 grades (Ridit analysis).
(3) three tame hospitalize group curative effects are (Ridit analysis) relatively.
3. efficacy assessment standard:
(1) cure: wound surface all heals.
(2) produce effects: wound surface dwindles more than 2/3.
(3) effective: wound surface dwindles between 1/3-2/3.
(4) invalid: wound surface dwindles below 1/3.
The result:
(1) treatment group and matched group witness relatively comprise the wound surface area change, and the wound surface pus how much, and difference compares before and after the treatment such as wound pain degree, and the P value all＜0.05 has significant difference on the statistics, show that the treatment group is better than matched group (seeing Table 1).
(2) treatment group and matched group healing time compare, and the treatment group is than on average healing in 4.74 days ahead of time of matched group, and P＜0.001 (seeing Table 1) shows that treatment group healing time is obviously faster than matched group.
(3) treatment group and matched group curative effect are relatively, the cure rate of treatment group is 94.2%, matched group is 60.95%, and cure obvious effective rate treatment group is 100%, matched group is 90.48%, two groups are compared the P value all＜0.05, show the healing of treatment group and cure obvious effective rate obviously to be better than matched group (seeing Table 2).
(4) three tame hospitalize groups are cured relatively P＞0.05 of obvious effective rate, and no significance is poor, so have objectivity, curative effect is reliable.
Toxic and side effects: 105 routine patients find no any toxic and side effects and anaphylaxis in treatment observation process, laboratory examination does not have hepatic and renal function injure yet, so drug safety is reliable.
Table 1 treatment group and matched group witness be (X ± SD analyzes) project treatment group (n=105) matched group n=105 P value relatively
Difference surface of a wound area % 7.60 ± 4.07 5.19 ± 3.0＜0.01 surface of a wound festers (scoring) 3.08 ± 1.21 1.72 ± 1.17＜0.001 surface of a wound pain (scoring) 3.55 ± 1.28 2.71 ± 1.06＜0.01 healing times before and after the difference treatment before and after the treatment group (day) 13.03 ± 4.29 17.78 ± 7.57＜0.001 table 2 treatment groups and control group curative effect relatively (Ridit analysiss) group n healing produce effects enabledisable R 95% (CI) P treatment group 105 99 6 0.6694 0.5913-0.7475＜three hospitalize groups of 0.05 control group, 105 64 31 82 tables 3 curative effect compare (Ridit analysis) n of unit healing produce effects enabledisable R 96% (CI) P 35 35 000 0.5571 0.4219-0.6924 of Guangxi Medical University＞35 35 200 0.5286 0.3933-0.6638 of 0.05 Yulin Prefecture hospital＞0.05303 hospital 35 31 400 (contrast)
Model case:
Example one: leaf * *, 67 years old, scald two limbs because of the pressure cooker blast and be admitted to hospital burn surface area 8% in 32 hours, shallow II degree, ordinary circumstance is good when being admitted to hospital, and the right lower extremity wound surface sprays golden imperial burn-treating liquid, every day 3-5 time, exposure method, left lower extremity is with the external application of 1%AGSD cold cream, the dressing wrapping, and every day, more change dressings was once.Second day wound surface drying of right lower extremity spray medicine, the medicine crust forms, pain relief, took off gradually in the 5th day silly, healing fully in the 7th day, and left lower extremity still had 1.5% wound surface that secretions is not more arranged on the 7th day.
Example two: once * *, man, 20 years old, the soldier, petrol burn breast abdomen waist, right upper extremity, area 26%, shallow II ° 14%, and dark II ° 10%, III ° 2%, hinders and is admitted to hospital in back 16 hours, gives fluid infusion after being admitted to hospital, quiet penicillin 6 days, after the wound surface normal saline cleaned, right upper extremity was coated with the 5%AGSD suspension outward, and breast abdomen waist is used golden imperial burn-treating liquid and sprayed, every day 6 times, treatment organize 2 the Heavenly Stems the dryness accumulated in the stomach and intestine crust, shallow II ° of healing in 7 days, dark II ° of healing in 16 days, matched group incrustation in 6 days, 12 days molten crusts of part also infect, and repaste AgSD is invalid, change the normal saline soak and cure in 42 days.
Discuss
(1) it is fast to prove that through several families hospital clinical application result golden imperial burn-treating liquid spray has into crust, restrains, and oozes out to lack, and to the protection wound surface, protects from infection, and promotes healing that better effects is arranged.
(2) golden imperial burn-treating liquid is a Chinese herbal and crude drugs preparations, and it is wide, easy to use to have a medicine source, need not wrap up, and can save a large amount of dressing, alleviates advantages such as patient economy burden, so welcome by the patient, very easily applies.
(3) this is organized 105 patients and is being in hospital or clinic case of selecting at random, observing the doctor reaches more than 10 people, all be to have the burn specialist who enriches clinical experience, treatment group and matched group are chosen in same patient and burn surface area, the degree of depth are identical on one's body during checking, this has just affirmed the objectivity that checking is observed, got rid of the influence of variable factors such as individual variation, so the result is reliable.
Conclusion:
The imperial burn-treating liquid of gold is according to the externally applied spray of traditional proved recipe in conjunction with the theoretical development of Chinese medicine, has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the effect of convergence granulation promoting.Through one attached institute of Guangxi Medical University, Yulin Prefecture hospital, No.303 Hospital, P.L.A. has carried out clinical verification to 105 routine burn patients, the cure rate of treatment group as a result is 94.29%, the cure rate of matched group is 60.95%, and cure obvious effective rate treatment group 100%, and matched group is 90.40%, both obviously are better than matched group at the treatment group.
The test of treatment traumatic surface:
The inventor has accepted various traumatic surface patients totally one hundred five ten many cases altogether for medical treatment since 1985, wherein there are knife injury, traumatic injury, machine to injure by a crashing object, the wound that has is infection suppurates, but with all making the wound recovery from illness very soon after the medicine coating of the present invention, the also very fast recovery of infecting of wound, cure rate is more than 95%.
Two, pharmacodynamics test
Guangxi Department of Public Health entrusts certain university pathology chamber to carry out pharmacodynamics test, and its result is: extracorporeal bacteria inhibitor test shows that product of the present invention " golden imperial burn-treating liquid " has bacteriostasis in various degree to sarcina, Bacillus proteus, streptococcus pneumoniae, Bacillus typhi, alpha streptococcus, golden Portugal bacterium, escherichia coli, bacillus subtilis, cured sample bacillus; The mice hot plate is caused pain and radiation to be caused good analgesic effect is bitterly arranged; Can obviously improve its curative effect score value to the rat experiment burn, and certain promotion wound healing effect is arranged; Cavia porcellus due to the histamine phosphate caused to itch very obviously antipruritic effect.
Three, toxicity test
Guangxi Department of Public Health entrusts certain medical university to carry out acute toxicity test and long term toxicity test, its result is: acute toxicity test, this product is coated with outward Cavia porcellus intact skin and damaged skin and controls medicine, maximum tolerated dose is 51.7g/kg, the Cavia porcellus single-use skin stimulates and the test of muptiple-use skin irritation, does not find tangible irritant reaction.This product is not observed anaphylaxis to the hypersensitive test of Cavia porcellus.Long term toxicity test: be coated with for 6 weeks outward continuously for Cavia porcellus intact skin and damaged skin with 4 times of dopes of this product respectively, do not see toxic reaction.Prompting this product is safe by clinical plan with using dosage, approach and the course of treatment.
Claims (3)
1. Chinese medicine for the treatment of burn, traumatic surface is characterized in that its main activated feedstock composition and parts by weight are:
Radix Gentianae 6-20 Flos Lonicerae 10-18
Radix Arnebiae (Radix Lithospermi) 8-18 catechu 8-15
Rhizoma Polygoni Cuspidati 12-20 Pseudobulbus Bletillae (Rhizoma Bletillae) 10-18
Radix Sanguisorbae 8-18 Cortex Phellodendri 7-15
Radix Et Rhizoma Rhei 8-16 Rhizoma Coptidis 4-12
Borneolum Syntheticum 0.3-0.8 glycerol 3-10
2. the described treatment of claim 1 is burnt, the production method of the Chinese medicine of traumatic surface, it is characterized in that earlier Flos Lonicerae, Radix Gentianae, Radix Arnebiae (Radix Lithospermi), the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Polygoni Cuspidati, Radix Sanguisorbae, Cortex Phellodendri, Radix Et Rhizoma Rhei, Rhizoma Coptidis, selected in Chinese medicine, pulverize, decoct 2-3 time with 3-5 times of clear water, each 1-3 hour, merge medicinal liquid, the elimination medicinal residues, be concentrated into then about 2/3 volume, to pulverize and use the dissolved catechu of clear water to add, the soak with ethanol of reuse 50-95% reclaims ethanol with circumfluence method then, adds Borneolum Syntheticum in the medicinal liquid, glycerol and antiseptic, sterilization then, bottling obtains product.
3. treatment burn according to claim 2, traumatic surface medicine production method is characterized in that medicinal liquid adds and add by weight after Borneolum Syntheticum, glycerol and the antiseptic that 5% starch makes ointment after transferring all that terminal disinfection, bottling obtain product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN96121425A CN1052420C (en) | 1996-12-06 | 1996-12-06 | Chinese medicine for curing burn and traumatic wound and its production method |
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| CN96121425A CN1052420C (en) | 1996-12-06 | 1996-12-06 | Chinese medicine for curing burn and traumatic wound and its production method |
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| CN1052420C true CN1052420C (en) | 2000-05-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100427118C (en) * | 2004-11-27 | 2008-10-22 | 黄贵昌 | Burn and scald medicine |
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| CN1102406C (en) * | 1998-09-24 | 2003-03-05 | 符俊梁 | Medicine for treating burn (scald) and preparation process |
| CN1086953C (en) * | 1999-04-15 | 2002-07-03 | 崔北双 | Medical oil for treating burn and scald and its preparing process |
| CN1090962C (en) * | 1999-04-29 | 2002-09-18 | 张金凤 | Shaoshangfu sukang ointment for curing burn |
| CN1331517C (en) * | 2005-07-06 | 2007-08-15 | 孙传红 | Plaster contg. tuber of hyacinth bletilla for treating burns |
| CN101167856B (en) * | 2007-10-26 | 2010-06-02 | 郭光华 | External-applied medicinal preparation for treating burns and its preparation method |
| CN101912462B (en) * | 2010-07-21 | 2012-06-27 | 潘少亮 | External paste for treating burn and scald and preparation method thereof |
| CN102000176B (en) * | 2010-11-17 | 2012-02-22 | 河南羚锐制药股份有限公司北京药物研究院 | Medicine composition for treating burns and scalds and preparation method thereof |
| CN103655745B (en) * | 2013-12-17 | 2016-05-18 | 广西厚德大健康产业股份有限公司 | A kind of pharmaceutical composition for the treatment of burn and scald |
| CN104491442B (en) * | 2014-12-26 | 2018-02-02 | 刘玉柱 | A kind of preparation technology for treating injury from electricity pharmaceutical composition |
| CN105194364A (en) * | 2015-09-06 | 2015-12-30 | 张玉玲 | Medicinal composition for local burn nursing |
| CN105663731A (en) * | 2016-03-10 | 2016-06-15 | 徐杰 | Traditional Chinese medicine emulsifiable paste for treating burns and scalds and preparation method and application thereof |
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| CN100427118C (en) * | 2004-11-27 | 2008-10-22 | 黄贵昌 | Burn and scald medicine |
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| CN1171259A (en) | 1998-01-28 |
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