CN109529204A - Superficial tumor close-range treatment applicating device manufacturing method and applicating device - Google Patents
Superficial tumor close-range treatment applicating device manufacturing method and applicating device Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1028—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy using radiation sources applied onto the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/1061—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
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Abstract
This application discloses a kind of superficial tumor close-range treatment applicating device manufacturing method and applicating devices, and wherein manufacturing method comprises determining that the target area range of patient Shi Shu；The parameter of applicating device is determined according to the target area range；Wherein, the parameter of the applicating device includes: binding face dimension information, thickness information and radioactive source channel information；Virtual three-dimensional applicating device model is established according to the parameter of the applicating device；According to the three-dimensional applicating device model, and by 3D printer, printing obtains the applicating device.Having reached the applicating device manufactured by this method can be accurately conformal with the body surface profile of patient, patient body-surface easily can be accurately fitted in compared with currently used applicating device, and pass through the purpose radiated source channels and can accurately carry out the release of radioactive source；To realize can precise positioning and reset, while saving resetting time, improve the technical effect of reseting precision.
Description
Technical field
This application involves manufacture technology field of medical appliance, use in particular to a kind of superficial tumor close-range treatment
Applicating device manufacturing method and applicating device.
Background technique
Close-range treatment is the essential therapeutic arsenals of part superficial tumor, and the rear dress especially based on Iridium-192 source source is controlled
It treats, is widely used in the treatment of cutaneum carcinoma, skin lymphoma in medical college, Harvard University.It is controlled compared to electric wire external exposure
It treats, close-range treatment is more suitable for rough superficial tumor.Because electron beam irradiation be difficult rough position to
Give the irradiation of tumour uniform dose.Presently the most common treatment method are as follows: direct-view is lower to observe superficial tumor range, determines tumour model
The range enclosed and may invaded determines the CTV for needing to irradiate with wire, then applies the dedicated close-range treatment of He Tong company
Source device more are placed in parallel in the surface CTV and fixation, then scanning computed tomography, according on CT image wire mark range of tumor and
The specific location of applicating device designs treatment plan, different by allowing different location of the Iridium-192 source source in every applicating device to stop
Time reaches the dosimeter requirement of target area.Presently used applicating device its have the following problems:
1, in the fixed relative difficulty of body surface, and accuracy is poor, and conformal performance is bad；
2, applicating device resets not easy enough before treating every time, and applicating device position cannot accurately reach one before treating every time
It causes；
3, location error will cause dosage accuracy difference between the gradation of applicating device；
4, for waiting especially irregular body surface between toe between finger, it is also necessary to cooperate thermoplastic film application, it is relatively more multiple
It is miscellaneous；
5, it cannot be guaranteed that each equal equidistantly distributed of applicating device；
6, the narrow gap in part is difficult to place applicating device.
For problem present in the relevant technologies, currently no effective solution has been proposed.
Summary of the invention
The main purpose of the application is to provide a kind of to be carried out applying art and effectively improves the shallow of accuracy convenient for healthcare givers
Table tumour close-range treatment applicating device manufacturing method and applicating device are asked with solving wherein one or more technologies in background technique
Topic.
To achieve the goals above, according to the one aspect of the application, a kind of superficial tumor close-range treatment use is provided
Applicating device manufacturing method.
According to the superficial tumor close-range treatment applicating device manufacturing method of the application, comprising:
Determine the target area range of patient Shi Shu；
The parameter of applicating device is determined according to the target area range；Wherein, the parameter of the applicating device includes: binding face size
Information, thickness information and radioactive source channel information；
Virtual three-dimensional applicating device model is established according to the parameter of the applicating device；
According to the three-dimensional applicating device model, and by 3D printer, printing obtains the applicating device.
Further, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, the determining patient Shi Shu
Target area range include:
The target area range is marked by wire；
The anchor point for installing the applicating device is determined according to the target area range；Wherein, the anchor point is set to the trouble
With person, for confirming installation site of the applicating device with the patient；
CT scan is carried out to the target area range, obtains CT image；Wherein the thickness of the CT scan is 3mm~7mm.
Further, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, it is described according to the target area
Range determines the parameter of applicating device, comprising:
Determine the range information of the target area range；
According to the binding face dimension information of the determination of the range information applicating device；Wherein, the binding face size
Information is the dimension information that the applicating device is bonded one side with human body surface, and the binding face dimension information is greater than the range
Information；
The thickness information of the applicating device is set in 8mm between 12mm；
The location information that the applicating device channel information includes: each applicating device channel is set, each applicating device is logical
The elevation information of binding face described in track pitch, the pitch information between the two neighboring applicating device channel.
Further, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, further includes:
According to the anchor point of the applicating device, the hole location of location hole corresponding with the anchor point on the applicating device is determined
Information and aperture information.
Further, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, further includes:
The order information in each applicating device channel is determined according to the location information in each applicating device channel；
It is determined according to the order information in each applicating device channel and is led to correspondingly with each applicating device channel
Road number.
Further, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, the determining patient Shi Shu
Target area range, further includes:
Cross mark line is left on patient skin by CT cross laser line；
Scanning obtains the CT image of the cross mark line；
Anchor point mark is affixed at the cross mark line on the patient skin.
Further, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, it is described that source is applied according to
The parameter of device establishes virtual three-dimensional applicating device model, further includes:
According to the CT image of the cross mark line on the binding face of the virtual three-dimensional applicating device model setting with
The corresponding cross of the cross mark line corresponds to line.
Further, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, further includes:
The direction of applicating device is determined according to the target area range；And
By 3D printer, marked in applicating device upper surface Print direction；The bearing mark is described for characterizing
Applicating device institute is towards direction.
To achieve the goals above, according to the another aspect of the application, it is described in any of the above embodiments to provide a kind of application
The applicating device of method manufacture.
Applicating device according to the application includes: the applicating device and radiation that the binding face of bottom is adapted to body surface chamfered shape
Source channels, the radiation source channels are equipped with one or more；Multiple radiation source channels are uniformly set to inside the applicating device,
And binding face of each radiation source channels with the bottom of the applicating device is arranged in parallel.
Further, the diameter of applicating device as the aforementioned, the radiation source channels is 1.00mm~2.20mm；Adjacent two
Vertical plane locating for a radiation source channels is parallel to each other, and spacing is 0.5cm~1.5cm.
In the embodiment of the present application, using a kind of superficial tumor close-range treatment applicating device manufacturing method and applicating device,
By the target area range for determining patient Shi Shu；The parameter of applicating device is determined according to the target area range；Wherein, the applicating device
Parameter includes: binding face dimension information, thickness information and radioactive source channel information；It is established according to the parameter of the applicating device virtual
Three-dimensional applicating device model；According to the three-dimensional applicating device model, and by 3D printer, printing obtains the applicating device.It reaches
Can be accurately conformal with the body surface profile of patient to the applicating device manufactured by this method, with currently used applicating device
Compared to easily being accurately fitted in patient body-surface, and pass through the mesh that the radiation source channels can accurately carry out the release of radioactive source
's；To realize can precise positioning and reset, while saving resetting time, improve the technical effect of reseting precision.
Detailed description of the invention
The attached drawing constituted part of this application is used to provide further understanding of the present application, so that the application's is other
Feature, objects and advantages become more apparent upon.The illustrative examples attached drawing and its explanation of the application is for explaining the application, not
Constitute the improper restriction to the application.In the accompanying drawings:
Fig. 1 is the applicating device manufacturing method flow diagram according to a kind of embodiment of the application；And
Fig. 2 is the applicating device structural schematic diagram according to a kind of embodiment of the application.
Specific embodiment
In order to make those skilled in the art more fully understand application scheme, below in conjunction in the embodiment of the present application
Attached drawing, the technical scheme in the embodiment of the application is clearly and completely described, it is clear that described embodiment is only
The embodiment of the application a part, instead of all the embodiments.Based on the embodiment in the application, ordinary skill people
Member's every other embodiment obtained without making creative work, all should belong to the model of the application protection
It encloses.
It should be noted that the description and claims of this application and term " first " in above-mentioned attached drawing, "
Two " etc. be to be used to distinguish similar objects, without being used to describe a particular order or precedence order.It should be understood that using in this way
Data be interchangeable under appropriate circumstances, so as to embodiments herein described herein.In addition, term " includes " and " tool
Have " and their any deformation, it is intended that cover it is non-exclusive include, for example, containing a series of steps or units
Process, method, system, product or equipment those of are not necessarily limited to be clearly listed step or unit, but may include without clear
Other step or units listing to Chu or intrinsic for these process, methods, product or equipment.
In this application, term " on ", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outside",
" in ", "vertical", "horizontal", " transverse direction ", the orientation or positional relationship of the instructions such as " longitudinal direction " be orientation based on the figure or
Positional relationship.These terms are not intended to limit indicated dress primarily to better describe the application and embodiment
Set, element or component must have particular orientation, or constructed and operated with particular orientation.
Also, above-mentioned part term is other than it can be used to indicate that orientation or positional relationship, it is also possible to for indicating it
His meaning, such as term " on " also are likely used for indicating certain relations of dependence or connection relationship in some cases.For ability
For the those of ordinary skill of domain, the concrete meaning of these terms in this application can be understood as the case may be.
In addition, term " installation ", " setting ", " being equipped with ", " connection ", " connected ", " socket " shall be understood in a broad sense.For example,
It may be a fixed connection, be detachably connected or monolithic construction；It can be mechanical connection, or electrical connection；It can be direct phase
It even, or indirectly connected through an intermediary, or is two connections internal between device, element or component.
For those of ordinary skills, the concrete meaning of above-mentioned term in this application can be understood as the case may be.
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase
Mutually combination.The application is described in detail below with reference to the accompanying drawings and in conjunction with the embodiments.
As shown in Figure 1, this application involves a kind of superficial tumor close-range treatment applicating device manufacturing method, the superficial tumor
Close-range treatment applicating device manufacturing method includes step S1 to S4 as described below:
S1. the target area range of patient Shi Shu is determined；Specifically, the target area range is to carry out the range area of radioactive source treatment
Domain, and the illness range of the cutaneum carcinoma or skin lymphoma of the range areas and patient surface is adapted；It can be by doctor in art
First three days are determined；
S2. the parameter of applicating device is determined according to the target area range；Wherein, the parameter of the applicating device includes: binding face
Dimension information, thickness information and radioactive source channel information；Specifically, the binding face generally carries out radioactive source treatment with patient
Body surface fitting is consistent；It is able to maintain when so that placing steady；The thickness information and radioactive source channel information can be with
It is configured according to the actual conditions in patient region；And the thickness of the applicating device is generally consistent, and the radiation
Source channels are always positioned at the middle of upper surface and binding face, thus the radiation source channels also can be with body surface
Distance keep stablize；
S3. virtual three-dimensional applicating device model is established according to the parameter of the applicating device；In general, computer can be passed through
Three-dimensional software first is rebuild to obtain the profile of the patient body-surface, position and range according to the target area range；Then in conjunction with described
The parameter of applicating device carries out the drafting of dummy model；Specifically used three-dimensional graphics software can be selected according to specific use
It selects, there is a large amount of three-dimensional graphics software, and graphics software and not this Applicant's Abstract graph main protection inventive point on the market at present, therefore
It is not specifically limited herein；
S4. according to the three-dimensional applicating device model, and by 3D printer, printing obtains the applicating device；Specifically, mesh
Preceding some more mature 3D printers existing on the market, and 3D printer and not this Applicant's Abstract graph main protection inventive point, because
This is not specifically limited herein.In general, the radiation source channels are the channel of section circle.And applicating device is using transparent or half
Transparent tissueequivalentmaterial carries out 3D printing, thus is observed that internal radiation source channels, it is easier to medical worker into
Row applies art.
The applicating device manufactured by this method can be accurately conformal with the body surface profile of patient, applies with currently used
Source device, which is compared, easily can accurately be fitted in patient body-surface, and can accurately carry out the release of radioactive source by the radiation source channels
Purpose；To realize can precise positioning and reset, while saving resetting time, improve the technical effect of reseting precision.
In some embodiments, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, the determining trouble
The target area range that person applies art includes:
The target area range is marked by wire；Preferably, when therapeutic domain can be exposed, it is most easypro to choose patient
Suitable position vacuum pad is fixed, and the target area range is obtained；
The anchor point for installing the applicating device is determined according to the target area range；Wherein, the anchor point is set to the trouble
With person, for confirming installation site of the applicating device with the patient；
CT scan is carried out to the target area range, obtains CT image；Wherein the thickness of the CT scan is 3mm~7mm.Tool
Body, it is described radiation source channels away from applicating device bottom surface it is highly preferred for it is described radiation source channels section center to bottom surface most
Distance nearby；It using the altitude range, can make radioactive source that there is the distance of a good radiotherapy, play preferable
Therapeutic effect.Preferably, the radiation height of the source channels away from applicating device bottom surface is 5mm.
In some embodiments, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, it is described according to institute
State the parameter that target area range determines applicating device, comprising:
Determine the range information of the target area range；Specifically, can be scanned when obtaining the target area range
To a skin surface scanning information for being greater than the target area range；And determine the target described in the skin surface scanning information
The range information of area's range；
According to the binding face dimension information of the determination of the range information applicating device；Wherein, the binding face size
Information is the dimension information that the applicating device is bonded one side with human body surface, and the binding face dimension information is greater than the range
Information；
The thickness information of the applicating device is set in 8mm between 12mm；Preferably, the thickness of the applicating device is set as
10mm；
The location information that the applicating device channel information includes: each applicating device channel is set, each applicating device is logical
The elevation information of binding face described in track pitch, the pitch information between the two neighboring applicating device channel.
In some embodiments, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, further includes:
According to the anchor point of the applicating device, the hole of location hole 5 corresponding with the anchor point on the applicating device is determined
Position information and aperture information.Specifically, the anchor point
In some embodiments, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, further includes:
The order information in each applicating device channel is determined according to the location information in each applicating device channel；
It is determined according to the order information in each applicating device channel and is led to correspondingly with each applicating device channel
Road number 3.
Specifically, the channel number, which can be, passes through number: 1, the modes such as 2,3 ... .. or letter A, B, C ... ... carry out
The label of different radiation source channels；It can make to apply and preoperative guarantee, which is applied, be planned to the position of radiotherapy or sequence in advance
Art can be carried out sequentially.
In some embodiments, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, the determining trouble
Person applies the target area range of art, further includes:
Cross mark line is left on patient skin by CT cross laser line；
Scanning obtains the CT image of the cross mark line；To record the position of the cross mark line, and by itself and target
Area's range carries out the CT image that CT scan obtains and is combined；
Anchor point mark is affixed at the cross mark line on the patient skin.
In some embodiments, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, it is described according to institute
The parameter for stating applicating device establishes virtual three-dimensional applicating device model, further includes:
According to the CT image of the cross mark line on the binding face of the virtual three-dimensional applicating device model setting with
The corresponding cross of the cross mark line corresponds to line 6.
And then corresponding cross can be also printed on the applicating device when carrying out 3D printing and correspond to line；And
Corresponding to line by the cross on the cross hairs mark line and the applicating device that leave on patient skin can be to applicating device
Fixed position is further calibrated, and guarantees that position is accurate.
In some embodiments, superficial tumor close-range treatment applicating device manufacturing method as the aforementioned, further includes:
The direction of applicating device is determined according to the target area range；And
By 3D printer, in the applicating device upper surface Print direction label 4；The bearing mark is described for characterizing
Applicating device institute is towards direction.Specifically, the bearing mark can be character for indicating direction, such as: upper and lower, left and right with
And arrow etc.；It can easily determine applicating device in the direction of body surface by the way that the bearing mark is arranged.
To achieve the goals above, according to the another aspect of the application, as shown in Fig. 2, providing a kind of above-mentioned of application
The applicating device of the manufacture of method described in one.
Applicating device according to the application includes: the applicating device and radiation that the binding face of bottom is adapted to body surface chamfered shape
Source channels, the radiation source channels are equipped with one or more；Multiple radiation source channels are uniformly set to inside the applicating device,
And binding face of each radiation source channels with the bottom of the applicating device is arranged in parallel.
In some embodiments, the diameter of applicating device as the aforementioned, the radiation source channels is 1.00mm~2.20mm；Phase
Vertical plane locating for two adjacent radiation source channels is parallel to each other, and spacing is 0.5cm~1.5cm.Preferably, the phase
The mutual spacing of vertical plane locating for the radiation source channels of adjacent two is 1cm.
A kind of application method of the applicating device of embodiment of the application is as described below:
Applicating device 1 is placed in patient body-surface, second step, according to 4th area of bearing mark according to natural body surface profile by the first step
Divide applicating device 1 in the direction of body surface, location hole 5 is pasted positioning cursor position with body surface and overlapped, keeps applicating device 1 smart by third step
Standard resets.CT laser lamp is moved to the cross on applicating device and corresponded on line 6, sees whether applicating device 1 has deflection, position by the 4th step
Whether precisely to set.Finally release radioactive source can be carried out in radiation source channels 2 accurately to be treated.
The foregoing is merely preferred embodiment of the present application, are not intended to limit this application, for the skill of this field
For art personnel, various changes and changes are possible in this application.Within the spirit and principles of this application, made any to repair
Change, equivalent replacement, improvement etc., should be included within the scope of protection of this application.
Claims (10)
1. a kind of superficial tumor close-range treatment applicating device manufacturing method characterized by comprising
Determine the target area range of patient Shi Shu；
The parameter of applicating device is determined according to the target area range；Wherein, the parameter of the applicating device includes: binding face size letter
Breath, thickness information and radioactive source channel information；
Virtual three-dimensional applicating device model is established according to the parameter of the applicating device；
According to the three-dimensional applicating device model, and by 3D printer, printing obtains the applicating device.
2. superficial tumor close-range treatment applicating device manufacturing method according to claim 1, which is characterized in that described true
The target area range for determining patient Shi Shu includes:
The target area range is marked by wire；
The anchor point for installing the applicating device is determined according to the target area range；Wherein, the anchor point is set to patient's body
On, for confirming installation site of the applicating device with the patient；
CT scan is carried out to the target area range, obtains CT image；Wherein the thickness of the CT scan is 3mm~7mm.
3. superficial tumor close-range treatment applicating device manufacturing method according to claim 2, which is characterized in that described
The parameter of applicating device is determined according to the target area range, comprising:
Determine the range information of the target area range；
According to the binding face dimension information of the determination of the range information applicating device；Wherein, the binding face dimension information
The dimension information of one side is bonded with human body surface for the applicating device, and the binding face dimension information is believed greater than the range
Breath；
The thickness information of the applicating device is set in 8mm between 12mm；
Set the location information that the applicating device channel information includes: each applicating device channel, each applicating device channel away from
The elevation information of the binding face, the pitch information between the two neighboring applicating device channel.
4. superficial tumor close-range treatment applicating device manufacturing method according to claim 3, which is characterized in that also wrap
It includes:
According to the anchor point of the applicating device, the hole location information of location hole corresponding with the anchor point on the applicating device is determined
And aperture information.
5. superficial tumor close-range treatment applicating device manufacturing method according to claim 3, which is characterized in that also wrap
It includes:
The order information in each applicating device channel is determined according to the location information in each applicating device channel；
It is compiled according to the order information in each applicating device channel is determining with each one-to-one channel in applicating device channel
Number.
6. superficial tumor close-range treatment applicating device manufacturing method according to claim 1, which is characterized in that described true
Determine the target area range of patient Shi Shu, further includes:
Cross mark line is left on patient skin by CT cross laser line；
Scanning obtains the CT image of the cross mark line；
Anchor point mark is affixed at the cross mark line on the patient skin.
7. superficial tumor close-range treatment applicating device manufacturing method according to claim 6, which is characterized in that described
Virtual three-dimensional applicating device model is established according to the parameter of the applicating device, further includes:
According to the CT image of the cross mark line on the binding face of the virtual three-dimensional applicating device model setting with it is described
The corresponding cross of cross mark line corresponds to line.
8. superficial tumor close-range treatment applicating device manufacturing method according to claim 1, which is characterized in that also wrap
It includes:
The direction of applicating device is determined according to the target area range；And
By 3D printer, marked in applicating device upper surface Print direction；The bearing mark applies source described in being used to characterize
Device institute is towards direction.
9. a kind of applicating device using the described in any item manufacturing method manufactures of claim 1 to 8 characterized by comprising bottom
The applicating device (1) and radiation source channels (2), the radiation source channels (2) that the binding face in portion is adapted to body surface chamfered shape are set
There is one or more；Multiple radiation source channels (2) are uniformly set to the applicating device (1) inside, and each radioactive source
Binding face of the channel (2) with the bottom of the applicating device (1) is arranged in parallel.
10. applicating device according to claim 9, which is characterized in that it is described radiation source channels (2) diameter be 1.00mm~
2.20mm；Vertical plane locating for the radiation source channels (2) of adjacent two is parallel to each other, and spacing is 0.5cm~1.5cm.
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| CN201811250082.XA CN109529204B (en) | 2018-10-25 | 2018-10-25 | Method for manufacturing applicator for superficial tumor brachytherapy and applicator |
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| CN201811250082.XA CN109529204B (en) | 2018-10-25 | 2018-10-25 | Method for manufacturing applicator for superficial tumor brachytherapy and applicator |
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| CN1370607A (en) * | 2001-02-20 | 2002-09-25 | 中国人民解放军第二军医大学 | Dressed superfacial high-dosage radiotherapy apparatus |
| CN204485110U (en) * | 2015-02-11 | 2015-07-22 | 张光明 | Skin carcinoma and superficial tumor plesioradiotherapy series apparatus for wave-energy source |
| CN105498099A (en) * | 2015-11-30 | 2016-04-20 | 北京大学第一医院 | Preparation method and system of tissue compensator |
| CN106237547A (en) * | 2016-08-29 | 2016-12-21 | 西南医科大学附属医院 | A kind of manufacture method of individuation closely single tube apparatus for wave-energy source |
| AU2018219671A1 (en) * | 2017-02-09 | 2019-08-29 | Oncobeta International Gmbh | Model for applying radiation, method for producing the same, and use thereof |
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