CN109528612A - Crease-resistant tightening cosmetic composition, lotion and its preparation method and application - Google Patents
Crease-resistant tightening cosmetic composition, lotion and its preparation method and application Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The present invention relates to a kind of crease-resistant tightening cosmetic compositions, lotion and its preparation method and application.Crease-resistant tightening cosmetic composition includes following active component: Radix Angelicae Sinensis, Radix Notoginseng, Astragalus membranacus, radix saposhnikoviae, Rhizoma Gastrodiae, glossy privet seed, Radix Glycyrrhizae, pot marigold, silk tree, okra, Argireline, acetyl group octapeptide -3, oligopeptides -3 and dipalmitoyl hydroxyproline.Above-mentioned crease-resistant tightening cosmetic composition is based on Chinese herbal medicine, and it is aided with biological micromolecule substance, safe without toxic side effect, and above-mentioned crease-resistant tightening cosmetic composition not only have the function of it is potent anti-ageing, the various malaise symptoms of skin can also be alleviated, improve sensitive skin, unimpeded skin nutrition channel and energy channel, restore skin elastic, improve skin brilliant white degree, keep skin young healthy vibrant, therefore above-mentioned crease-resistant tightening cosmetic composition is suitable for preparing skin care item.
Description
Technical field
The present invention relates to technical field of daily necessities, in particular to crease-resistant tightening cosmetic composition, lotion and preparation method thereof and answer
With.
Background technique
With age, body starts gradually aging, and human metabolism starts to slow down, and moisture and subcutaneous fat subtract
Few, the quantity of human body fibroblast gradually decreases, and the collagen and elastin of secretion are also oxidized, and epidermis loses branch
Support act on and occur it is inhomogenous collapse, skin corium also starts thinning, and skin elasticity is deteriorated, and gloss gradually subsides, the most obviously
The generation for showing as wrinkle.And as people's lifestyle changes, increasingly paying attention to skin aesthetic feeling, the generation of wrinkle is special
It is not that influence of the generation of facial skin wrinkle to beauty is the most prominent.
Thus countless skin-protection products is expedited the emergence of out, but has portioned product excessively to pay attention to anti-aging effects, and is used some strong
Chemical reagent is imitated, such product, although can obtain preferable effect in the short term, long-time service is easy to produce according to resistance to
Property, increase skin burden, accelerates skin aging instead.
Summary of the invention
Based on this, it is necessary to provide a kind of safely and effectively crease-resistant tightening cosmetic composition, lotion and its preparation method and application.
A kind of crease-resistant tightening cosmetic composition, including following active component: Radix Angelicae Sinensis, Radix Notoginseng, Astragalus membranacus, radix saposhnikoviae, Rhizoma Gastrodiae, glossy privet
Seed, Radix Glycyrrhizae, pot marigold, silk tree, okra, Argireline, acetyl group octapeptide -3, oligopeptides -3 and two palmityl hydroxyl dried meat ammonia
Acid.
Radix Angelicae Sinensis has effects that anti-skin aging, freckle, anti-pachylosis and anti-inflammatory in above-mentioned crease-resistant tightening cosmetic composition.And
It has now been found that Radix Angelicae Sinensis can increase the superoxide dismutase (SOD of skin)Vigor prevents the continuous hair of radical reaction
The accumulation with unwanted metabolic products are given birth to, mouse skin aging caused by effective antagonism D- galactolipin shows that it can stimulate aging
Skin fibroblasts vigor promotes collagen synthesis, plays the effect of anti aging effect.
Radix Notoginseng main component are as follows: saponin(e, flavone compound, dencichine and polysaccharide, wherein saponin(e has stronger promoting blood circulation
Effect, is the main composition of Radix Notoginseng.And Flavonoid substances can effectively improve the permeability of blood vessel, to promote skin
Microcirculation, unimpeded skin corium nutrition channel, and then change and improve elasticity of skin.
Astragalus membranacus astragalus polyose rich in, astragalus polyose can increase the SOD level declined by aging, reduce blood
The content of lipid peroxide in slurry reduces lipofuscin and is formed, the lipofuscin formed in scavenger-cell；It can also reduce certainly
By the production of base, enhance the scavenging effect of free radical.In addition, there are also studies have shown that astragalus polyose has significant Immune enhancement
Effect improves mononuclear-macrophage phagocytic function, enhances skin sensitivity defense function.
There is glossy privet seed anti-oxidant, enhancing to be immunized, inhibit urase, fresh-keeping and other effects.And its fatty acid rich in, with
Unsaturated oleic acid and linoleic acid content highest, unsaturated double-bond therein can enhance the reaction energy of antioxidant and free radical
Power reaches anti-aging function so that the fruit of glossy privet has preferable scavenging effect to free radical.
Glycyrrhizin rich in Radix Glycyrrhizae, hydrolysate are enoxolone, the chemical structure and kidney of enoxolone
Upper gland cortin is similar, has anti-inflammatory, antitoxin, antianaphylactic effect, and can inhibit the release of histamine, to red and swollen skin
Tool has a better effect, and can alleviate, calm skin, improve sensitive skin.
Radix saposhnikoviae has effects that expel pathogenic wind from the body surface, damp-clearing pain-relieving, dispelling wind and arresting itching, has preferably especially for dermatophyte
Inhibiting effect can enhance the resistant function of skin.
Rhizoma Gastrodiae has good activation to Sudismase, catalase and glutathione peroxidase, can have
Free radical is eliminated on effect ground, plays anti-ageing effect, and research shows that the Rhizoma Gastrodiae extract of high concentration has activation to melanocyte
Effect has the function of improving the colour of skin, and it has the function of preferably pacifying that skin is antipruritic, skin of calming.
Pot marigold can administer the symptoms such as inflammation, dark sore, pore be coarse, while can also be effectively facilitated skin new old generation
The effect of thanking, and then improve the moist degree of skin.In particular, its anti-inflammatory, the effect of calm skin, especially pronounced, can obviously change
Kind sensitive skin, repairs scar.
For the skin of silk tree containing ingredients such as saponin, tannins, the fresh leaf acquired in 5 months contains vitamin C, has the work of calm peace skin
With, and it can also play and arrange turbid effect well, effectively clear impurity, assign elastic force, propose the colour of skin.
Okra can protect skin rich in having carotenoid and beta carotene, reduce radical damage.While its
Vitamin C and Soluble Fiber also rich in not only have healthcare function to skin, and can make skin-whitening, delicacy.
Argireline is the N-terminal duplicate of SNAP-25, in SNARE compound with its competitive position, and then reduce
The stability of SNARE compound so that vesica can not be released effectively neurotransmitter, to weaken contraction of muscle, prevent microgroove and
The formation of wrinkle.
Acetyl group octapeptide -3 can be reduced by the alternative mechanism of botulin toxin to be made by the contraction of facial expression muscle
At wrinkle depth, reduce local expression line, the stability of SNARE compound can also be reduced to weaken the emerging of neuron
Putting forth energy property reduces the stimulation of the facial muscles due to caused by the release of excessive neurotransmitter, alleviate skin due to excessively nervous and
Caused wrinkle.
Oligopeptides -3 is the tridecanoic peptide that alanine and leucine-lysine and phenylalanine form, and is that one kind can promote into
The substance of fibroblast growth.It can act on skin by exogenous, and after dermal layer of the skin cell combination, skin can be changed
The metabolism of skin cell tissue improves microcirculation, and skin corium fibroblast proliferation can be promoted to break up, effectively restore subcutaneous connective
The growth of tissue, and keep skin fine and smooth, rich in gloss, increasing elasticity smoothes away wrinkles, and has deep layer repair, can be used for newly producing
Raw acne is cheated, is repaired after laser, after point spot mole anti-acne, is repaired after red capillary instrumentation.
Dipalmitoyl hydroxyproline is a kind of potent anti-aging substance, has stimulation collagen more stronger than vitamin C
Filament contraction and the effect for inhibiting elastase activity, can play the role of shrink collagen fiber, protect elastin laminin, into
And reaching prevents skin aging, restores the effect of elastic skin.
Above-mentioned crease-resistant tightening cosmetic composition is aided with biological micromolecule substance based on Chinese herbal medicine, safe without toxic side effect, and
Each component mutually cooperates in above-mentioned crease-resistant tightening cosmetic composition, on the one hand promotes self generation and protection collagen from different approaches
And elastomer；On the other hand inhibit the release of neurotransmitter acetylcholine, block nerves conduction reduces the frequency of contraction of muscle
Rate；Reach compact skin, smooth microgroove and long-term anti-ageing effect.
In addition, passing through Radix Angelicae Sinensis, Radix Notoginseng, Astragalus membranacus, glossy privet seed, Radix Glycyrrhizae activating blood circulation and supplementing qi, unimpeded skin in above-mentioned composition
Nutrition channel and energy channel restore skin elastic, improve skin brilliant white degree, and pass through Astragalus membranacus, radix saposhnikoviae, pot marigold, conjunction
Vigorously, Rhizoma Gastrodiae, gumbo alleviate the various malaise symptoms of skin, repair skin barrier, give skin comprehensive security guarantee, improve sensitive flesh
Skin, it is long-acting to consolidate barrier, and then keep skin young healthy vibrant.
In one embodiment, in above-mentioned crease-resistant tightening cosmetic composition, the Radix Angelicae Sinensis, Radix Notoginseng, Astragalus membranacus, glossy privet seed,
Radix Glycyrrhizae, radix saposhnikoviae, pot marigold, silk tree, Rhizoma Gastrodiae and okra are the extract of corresponding raw material；
In the crease-resistant tightening cosmetic composition, in parts by weight, angelica extract is 1-8 parts, and Radix Notoginseng root extract is 1-8
Part, Astragalus membranaceus extract is 1-12 parts, and glossy privet seed extract is 1-5 parts, and licorice is 1-5 parts, and Radix Saposhnikoviae extract is
0.5-3 parts, calendula extract is 0.5-3 parts, and albizzia julibrissin extract is 0.5-3 parts, and Rhizoma Gastrodiae extract is 0.5-3 parts, okra
Extract is 0.01-2 parts, and the Argireline is 0.0001-0.1 parts, and the acetyl group octapeptide -3 is 0.0001-0.1
Part, the oligopeptides -3 is 0.0101-0.1 parts and the dipalmitoyl hydroxyproline is 0.001-1 parts.
It is monarch with Radix Angelicae Sinensis, Radix Notoginseng, Astragalus membranacus according to " monarch, minister, help, make " combination principle of Chinese medicine, radix saposhnikoviae, Rhizoma Gastrodiae are
Minister, glossy privet seed, Radix Glycyrrhizae, pot marigold are assistant, and silk tree and okra are to make, and have above-mentioned crease-resistant tightening cosmetic composition stronger crease-resistant
Effect, and long-acting can also consolidate barrier, keep skin young healthy vibrant.
In one embodiment, in the crease-resistant tightening cosmetic composition, in parts by weight, angelica extract is 3-6 parts,
Radix Notoginseng root extract is 3-6 parts, and Astragalus membranaceus extract is 2-8 parts, and Radix Saposhnikoviae extract is 1-3 parts, Rhizoma Gastrodiae extract 1-3
Part, glossy privet seed extract is 2-4 parts, and licorice is 2-4 parts, and calendula extract is 2-4 parts, albizzia julibrissin extract 0.5-
1 part, Abelmoschus Esculentus Linn extract is 0.5-1 parts, and the Argireline is 0.0001-0.01 parts, and the acetyl group octapeptide -3 is
0.0001-0.01 parts, the oligopeptides -3 is 0.0001-0.01 parts and the dipalmitoyl hydroxyproline is 0.0001-0.01 parts.
The preparation method of above-mentioned crease-resistant tightening cosmetic composition, comprising the following steps: by the Radix Angelicae Sinensis, Radix Notoginseng, Astragalus membranacus, prevent
Wind, Rhizoma Gastrodiae, glossy privet seed, Radix Glycyrrhizae, pot marigold, silk tree, okra, Argireline, acetyl group octapeptide -3, oligopeptides -3 and two palm fibres
The mixing of palmitic acid acyl hydroxyproline.
Above-mentioned crease-resistant tightening cosmetic composition is preparing the application in skin care item.
Above-mentioned crease-resistant tightening cosmetic composition is aided with biological micromolecule substance based on Chinese herbal medicine, safe without toxic side effect, and
Above-mentioned crease-resistant tightening cosmetic composition not only have the function of it is potent anti-ageing, can also alleviate the various malaise symptoms of skin, improve it is sensitive
Skin, unimpeded skin nutrition channel and energy channel restore skin elastic, improve skin brilliant white degree, there is skin young healthy
Vigor, therefore above-mentioned crease-resistant tightening cosmetic composition is suitable for preparing skin care item.
One kind is crease-resistant tightly to cause acceptable auxiliary material and solvent in lotion, including above-mentioned crease-resistant tightening cosmetic composition, skin care item.
Above-mentioned crease-resistant compact lotion safe without toxic side effect, and have it is potent it is anti-ageing, alleviate the various malaise symptoms of skin, change
The effect of kind sensitivity skin can be restored skin elastic, be improved skin brilliant white with unimpeded skin nutrition channel and energy channel
Degree, keeps skin young healthy vibrant.
In one embodiment, in the crease-resistant compact lotion, the weight percent of the crease-resistant tightening cosmetic composition contains
Amount is 1%-20%.
In one embodiment, in the crease-resistant compact lotion, the weight percent of the crease-resistant tightening cosmetic composition contains
Amount is 4%-18%.
In one embodiment, in the crease-resistant compact lotion, the angelica extract, the Roots of Panax Notoginseng are extracted
The sum of object, the Astragalus membranaceus extract, the glossy privet seed extract and mass percentage of the licorice are
0.05%-7%；
The quality percentage of the Radix Saposhnikoviae extract, the calendula extract, albizzia julibrissin extract and the Rhizoma Gastrodiae extract
The sum of content is 0.05%-6%；
The Abelmoschus Esculentus Linn extract, the Argireline, the acetyl group octapeptide -3, the oligopeptides -3 and described two
The sum of mass percentage of palmityl hydroxyproline is 0.01%-5%.
In one embodiment, in the crease-resistant compact lotion, the angelica extract, the Roots of Panax Notoginseng are extracted
The sum of object, the Astragalus membranaceus extract, the glossy privet seed extract and mass percentage of the licorice are
0.5%-5%；
The quality percentage of the Radix Saposhnikoviae extract, the calendula extract, albizzia julibrissin extract and the Rhizoma Gastrodiae extract
The sum of content is 0.5%-4%；
The Abelmoschus Esculentus Linn extract, the Argireline, the acetyl group octapeptide -3, the oligopeptides -3 and described two
The sum of mass percentage of palmityl hydroxyproline is 0.1%-3%.
In one embodiment, the auxiliary material includes: moisturizer, anti-sensitizer, thickener, solubilizer and odorant；
The moisturizer is glycerol, Natrulon H-10, glycine betaine, hyaluronic acid, butanediol, propylene glycol, pungent glycol and 1,2-
One of hexylene glycol is a variety of；
The anti-sensitizer is allantoin；
The thickener is xanthan gum；
The solubilizer is Cremophor RH40；
The odorant is essence.
In one embodiment, the moisturizer is glycerol, Natrulon H-10, glycine betaine, hyaluronic acid, butanediol, third
The combination of glycol, pungent glycol and 1,2- hexylene glycol；
In the crease-resistant compact lotion, the glycerol is 2%-10%, and the Natrulon H-10 is 1%-4%, the sweet tea
Dish alkali is 0.1%-2%, and the hyaluronic acid is 0.01%-0.1%, and the butanediol is 2%-6%, and the propylene glycol is
1%-4%, the pungent glycol are 0.2%-0.7%, and 1, the 2- hexylene glycol is 0.1%-0.5%, and the allantoin is
0.01%-0.1%, the xanthan gum are 0.01%-0.3%, and the Cremophor RH40 is 0.1%-0.3%, described
Essence is 0.02-0.1%.
The preparation method of above-mentioned crease-resistant compact lotion, comprising the following steps:
The auxiliary material and solvent are mixed, are uniformly dispersed under conditions of 50 DEG C -90 DEG C, is cooled to 45 DEG C hereinafter, being added
The crease-resistant compact lotion stirs evenly up to the crease-resistant compact lotion.
The preparation method of above-mentioned crease-resistant compact lotion, comprising the following steps:
By the allantoin, the Natrulon H-10, the glycine betaine and the water, stirred under conditions of 65 DEG C -75 DEG C
Uniformly；
The xanthan gum, the hyaluronic acid, the glycerol and the butanediol is added, and is warming up to 82 DEG C -85 DEG C,
Matter 3-10 minutes；
42 DEG C -45 DEG C are cooled to, the angelica extract, the Radix Notoginseng root extract, the Astragalus membranacus is added and extracts
Object, the glossy privet seed extract, the licorice, the Radix Saposhnikoviae extract, the calendula extract, albizzia julibrissin extract
With the Rhizoma Gastrodiae extract, stir evenly；
The essence, the propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, stirs to molten
Liquid is transparent；
Be cooled to 40 DEG C hereinafter, adjust solution pH to 4-6, the Abelmoschus Esculentus Linn extract, the acetyl group hexapeptide-is added
8, the acetyl group octapeptide -3, the oligopeptides -3 and the dipalmitoyl hydroxyproline stir evenly to get described crease-resistant compact
Lotion.
Reasonable material order of addition is selected according to feedstock property, on the one hand can keep the activity of active component, it is another
Aspect can make crease-resistant compact lotion obtained have preferable physical behavior.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
Embodiment 1
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of embodiment 1
It 1) is 15%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method:
(1) allantoin, Natrulon H-10, glycine betaine and water are added in emulsion pot, are stirred evenly under conditions of 70 DEG C；
(2) xanthan gum, hyaluronic acid, glycerol and butanediol is added, and is warming up to 82 DEG C -85 DEG C, homogeneous 3-5 minutes, until
It is completely dispersed uniformly, keeps the temperature 20-30 minutes and sterilize；
(3) 42 DEG C are cooled to, angelica extract, Radix Notoginseng root extract, Astragalus membranaceus extract, glossy privet seed is added and extracts
Object, licorice, Radix Saposhnikoviae extract, calendula extract, albizzia julibrissin extract and Rhizoma Gastrodiae extract, stir evenly；
(4) essence, propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, at 48 DEG C -42 DEG C
Under the conditions of, stirring to solution is transparent；
(5) be cooled to 40 DEG C hereinafter, adjust solution pH to 4-6, be added Abelmoschus Esculentus Linn extract, Argireline, second
Acyl group octapeptide -3, oligopeptides -3 and dipalmitoyl hydroxyproline, stir evenly；
(6) it samples, detection, after qualified, filtering, 38 DEG C of whens discharge, and the crease-resistant compact lotion of embodiment 1, appearance is made
And physical and chemical index is as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.11；
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
The component (parts by weight) of the crease-resistant tightening cosmetic composition of embodiment 1- embodiment 6
Embodiment 2
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of embodiment 2
It 1) is 12%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method:
(1) allantoin, Natrulon H-10, glycine betaine and water are added in emulsion pot, are stirred evenly under conditions of 70 DEG C；
(2) xanthan gum, hyaluronic acid, glycerol and butanediol is added, and is warming up to 82 DEG C -85 DEG C, homogeneous 3-5 minutes, until
It is completely dispersed uniformly, keeps the temperature 20-30 minutes and sterilize；
(3) 42 DEG C are cooled to, angelica extract, Radix Notoginseng root extract, Astragalus membranaceus extract, glossy privet seed is added and extracts
Object, licorice, Radix Saposhnikoviae extract, calendula extract, albizzia julibrissin extract and Rhizoma Gastrodiae extract, stir evenly；
(4) essence, propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, at 48 DEG C -42 DEG C
Under the conditions of, stirring to solution is transparent；
(5) be cooled to 40 DEG C hereinafter, adjust solution pH to 4-6, be added Abelmoschus Esculentus Linn extract, Argireline, second
Acyl group octapeptide -3, oligopeptides -3 and dipalmitoyl hydroxyproline, stir evenly；
(6) it samples, detection, after qualified, filtering, 38 DEG C of whens discharge, and the crease-resistant compact lotion of embodiment 2, appearance is made
And physical and chemical index is as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.23；
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Embodiment 3
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of embodiment 3
It 1) is 12%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method:
(1) allantoin, Natrulon H-10, glycine betaine and water are added in emulsion pot, are stirred evenly under conditions of 70 DEG C；
(2) xanthan gum, hyaluronic acid, glycerol and butanediol is added, and is warming up to 82 DEG C -85 DEG C, homogeneous 3-5 minutes, until
It is completely dispersed uniformly, keeps the temperature 20-30 minutes and sterilize；
(3) 42 DEG C are cooled to, angelica extract, Radix Notoginseng root extract, Astragalus membranaceus extract, glossy privet seed is added and extracts
Object, licorice, Radix Saposhnikoviae extract, calendula extract, albizzia julibrissin extract and Rhizoma Gastrodiae extract, stir evenly；
(4) essence, propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, at 48 DEG C -42 DEG C
Under the conditions of, stirring to solution is transparent；
(5) be cooled to 40 DEG C hereinafter, adjust solution pH to 4-6, be added Abelmoschus Esculentus Linn extract, Argireline, second
Acyl group octapeptide -3, oligopeptides -3 and dipalmitoyl hydroxyproline, stir evenly；
(6) it samples, detection, after qualified, filtering, 38 DEG C of whens discharge, and the crease-resistant compact lotion of embodiment 3, appearance is made
And physical and chemical index is as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.09；
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Embodiment 4
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of embodiment 4
It 1) is 12%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method:
(1) allantoin, Natrulon H-10, glycine betaine and water are added in emulsion pot, are stirred evenly under conditions of 70 DEG C；
(2) xanthan gum, hyaluronic acid, glycerol and butanediol is added, and is warming up to 82 DEG C -85 DEG C, homogeneous 3-5 minutes, until
It is completely dispersed uniformly, keeps the temperature 20-30 minutes and sterilize；
(3) 42 DEG C are cooled to, angelica extract, Radix Notoginseng root extract, Astragalus membranaceus extract, glossy privet seed is added and extracts
Object, licorice, Radix Saposhnikoviae extract, calendula extract, albizzia julibrissin extract and Rhizoma Gastrodiae extract, stir evenly；
(4) essence, propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, at 48 DEG C -42 DEG C
Under the conditions of, stirring to solution is transparent；
(5) be cooled to 40 DEG C hereinafter, adjust solution pH to 4-6, be added Abelmoschus Esculentus Linn extract, Argireline, second
Acyl group octapeptide -3, oligopeptides -3 and dipalmitoyl hydroxyproline, stir evenly；
(6) it samples, detection, after qualified, filtering, 38 DEG C of whens discharge, and the crease-resistant compact lotion of embodiment 4, appearance is made
And physical and chemical index is as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.17；
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Embodiment 5
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of embodiment 5
It 1) is 12%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method:
(1) allantoin, Natrulon H-10, glycine betaine and water are added in emulsion pot, are stirred evenly under conditions of 70 DEG C；
(2) xanthan gum, hyaluronic acid, glycerol and butanediol is added, and is warming up to 82 DEG C -85 DEG C, homogeneous 3-5 minutes, until
It is completely dispersed uniformly, keeps the temperature 20-30 minutes and sterilize；
(3) 42 DEG C are cooled to, angelica extract, Radix Notoginseng root extract, Astragalus membranaceus extract, glossy privet seed is added and extracts
Object, licorice, Radix Saposhnikoviae extract, calendula extract, albizzia julibrissin extract and Rhizoma Gastrodiae extract, stir evenly；
(4) essence, propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, at 48 DEG C -42 DEG C
Under the conditions of, stirring to solution is transparent；
(5) be cooled to 40 DEG C hereinafter, adjust solution pH to 4-6, be added Abelmoschus Esculentus Linn extract, Argireline, second
Acyl group octapeptide -3, oligopeptides -3 and dipalmitoyl hydroxyproline, stir evenly；
(6) it samples, detection, after qualified, filtering, 38 DEG C of whens discharge, and the crease-resistant compact lotion of embodiment 5, appearance is made
And physical and chemical index is as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.14；
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Embodiment 6
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of embodiment 6
It 1) is 12%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method:
(1) allantoin, Natrulon H-10, glycine betaine and water are added in emulsion pot, are stirred evenly under conditions of 70 DEG C；
(2) xanthan gum, hyaluronic acid, glycerol and butanediol is added, and is warming up to 82 DEG C -85 DEG C, homogeneous 3-5 minutes, until
It is completely dispersed uniformly, keeps the temperature 20-30 minutes and sterilize；
(3) 42 DEG C are cooled to, angelica extract, Radix Notoginseng root extract, Astragalus membranaceus extract, glossy privet seed is added and extracts
Object, licorice, Radix Saposhnikoviae extract, calendula extract, albizzia julibrissin extract and Rhizoma Gastrodiae extract, stir evenly；
(4) essence, propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, at 48 DEG C -42 DEG C
Under the conditions of, stirring to solution is transparent；
(5) be cooled to 40 DEG C hereinafter, adjust solution pH to 4-6, be added Abelmoschus Esculentus Linn extract, Argireline, second
Acyl group octapeptide -3, oligopeptides -3 and dipalmitoyl hydroxyproline, stir evenly；
(6) it samples, detection, after qualified, filtering, 38 DEG C of whens discharge, and the crease-resistant compact lotion of embodiment 6, appearance is made
And physical and chemical index is as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.20；
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Comparative example 1
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of comparative example 1
It 2) is 12%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method: with embodiment 3
The appearance and physical and chemical index of the crease-resistant compact lotion of comparative example 1 are as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.23；
Heat-resisting (45 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 17 ± 2 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Table 2: the component (parts by weight) of the crease-resistant tightening cosmetic composition of comparative example 1- comparative example 3
Comparative example 2
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of comparative example 2
It 2) is 12%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method: with embodiment 3
The appearance and physical and chemical index of the crease-resistant compact lotion of comparative example 2 are as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.17；
Heat-resisting (4542 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 1742 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Comparative example 3
The mass percentage of crease-resistant each raw material of compact lotion is as follows: crease-resistant tightening cosmetic composition (the component such as table of comparative example 3
It 2) is 12%, glycerol 6%, Natrulon H-10 2%, the glycine betaine is 1%, hyaluronic acid 0.05%, and butanediol is
4%, propylene glycol 2%, pungent glycol is 0.5%, and 1,2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%,
Cremophor RH40 is 0.15%, essence 0.04%, water surplus.
Preparation method: with embodiment 3
The appearance and physical and chemical index of the crease-resistant compact lotion of comparative example 3 are as follows:
Appearance: transparent flow liquid；
PH value (straight to survey): 5.13；
Heat-resisting (4542 DEG C): 3 months, restoring room temperature, without exception；
Cold-resistant (- 1742 DEG C): 3 months, restoring room temperature, without exception；
Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.
Comparative example 4
Without containing crease-resistant tightening cosmetic composition, auxiliary material is contained only.Specifically, raw material forms are as follows: glycerol 6%, Natrulon H-10 are
2%, the glycine betaine is 1%, hyaluronic acid 0.05%, butanediol 4%, propylene glycol 2%, and pungent glycol is 0.5%, 1,
2- hexylene glycol is 0.2%, allantoin 0.05%, xanthan gum 0.1%, Cremophor RH40 0.15%, and essence is
0.04%, water surplus.
Preparation method:
(1) allantoin, Natrulon H-10, glycine betaine and water are added in emulsion pot, are stirred evenly under conditions of 70 DEG C；
(2) xanthan gum, hyaluronic acid, glycerol and butanediol is added, and is warming up to 82 DEG C -85 DEG C, homogeneous 3-5 minutes, until
It is completely dispersed uniformly, keeps the temperature 20-30 minutes and sterilize；
(3) essence, propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, at 48 DEG C -42 DEG C
Under the conditions of, stirring to solution is transparent；
(4) be cooled to 40 DEG C hereinafter, adjust solution pH to 4-6, stir evenly.
Compliance test result experiment
Test product: the lotion of embodiment 3, comparative example 1- comparative example 4.
Test crowd:, age distribution 20-55 years old, being randomly divided into five groups by volunteer 100, and every group 20, and five groups of years
Age, gender, skin condition are statistically analyzed, and no significant difference (P > 0.05) is comparable.Wherein, first group
Using the product of embodiment 3, second group of product using comparative example 1, third group uses the product of comparative example 2, the 4th group of use
The product of comparative example 3, the 5th group of product using comparative example 4.
Application method: it is 2-3 times daily, it is used continuously 3 months.
Test item: (1) skin wrinkle improves situation；(2) elasticity of skin improves situation；(3) colour of skin improves situation；(4)
Skin microcirculation improves situation；(5) sensitive skin improves situation.
Test method and test result:
(1) skin wrinkle improves situation
Instrument: VISA face-image analysis system
Test method: 5 test points, respectively glabella line, forehead line, crow's feet, nasolabial groove and lip week wrinkle are chosen
Line takes the skin of same area every time when test as far as possible, and when test loosens.Using the test result before unused product as blank
Control, test improve situation using product 3 months wrinkles, and each region is surveyed 3 times every time, counts everyone each area test
Value, averages.
Evaluation criteria:
10 points, without wrinkle；
7-9 points, there is 2-3 wrinkle, length is less than 1.5cm；
4-6 points, there is 3-6 wrinkle, length is less than 3cm；
1-3 points, there are several main wrinkles, length is greater than 4cm, is also accompanied by shallow wrinkle.
Test result such as table 3
Table 3
From table 3 it can be seen that first group of volunteer's wrinkle improvement situation is more obvious, compared to second group~the 5th group
Effect is more excellent, illustrates that the lotion of embodiment 3 has better anti-wrinkle effect.Wherein, acetyl is not contained for second group and the 4th group
Base hexapeptide -8, acetyl group octapeptide -3, oligopeptides -3 and dipalmitoyl hydroxyproline biological micromolecule substance.From table 3 it can be seen that
Second group, the 4th group of wrinkle improves situation has and largely decline with third group compared to first group, illustrate above-mentioned life
Object small-molecule substance can significantly increase the wrinkling resistance of product.In addition, third group is compared with first group, in the lotion used
Angelica extract and Radix Notoginseng root extract are lacked, from experimental result as can be seen that the wrinkle of third group, which alleviates situation, is markedly less than the
One group, the wrinkling resistance of product can be enhanced by illustrating above two component equally.
(2) elasticity of skin improves situation
Instrument: MPA580 skin elasticity tester
Evaluation criteria: skin elasticity index R2It indicates, R2Illustrate that skin elasticity is better closer to 1 (100%), to every group
R2Fingering row statistics, and take mean value.Test result such as table 4.
Table 4
(* * p < 0.01)
From table 4, it can be seen that first group of volunteer's elasticity of skin situation, which improves situation, is substantially better than the second group~the 5th
Group illustrates that elasticity of skin can be improved in the product of embodiment 3.In addition, the result trend basic one of the above results trend and table 3
It causes, demonstrates again that the product of embodiment 3 has the effect of crease-resistant compact skin.
(3) colour of skin improves situation
Instrument: VISA face-image analysis system and Image-Pro Plus image analysis software
Test index: the skin brilliant white degree before and after test use is indicated, ITA ° of value is bigger, and skin gets over brilliant white, instead with ITA °
It, skin is more obscure, to every group of R2Fingering row statistics, and take mean value.Test result such as table 5.
Table 5
(* p < 0.05)
As can be seen from Table 5, first group of volunteer's colour of skin improvement situation is substantially better than second group~the 5th group, illustrates reality
The product for applying example 3 can be obviously improved the white luminance of skin, and it is dark yellow to improve skin.
(4) skin microcirculation improves situation
Instrument: laser-Doppler blood flow tester
Test is given advice: being tested the blood perfusion amount V at the same position in cheek portion before and after each group volunteer use respectively, is united
Meter, and take mean value.
Table 6
(* p < 0.05)
As can be seen from Table 6, the skin microcirculation improvement situation of first group of volunteer is substantially better than the second group~the 5th
Group.Illustrate that the product of embodiment 3 can significantly improve face skin blood perfusion amount, promote skin microcirculation, unimpeded skin is true
Cortex nutrition channel, and then profound improvement skin.
(5) sensitive skin improves situation
Test method: being tested using lactic acid prick test method, specifically, in the muffle ditch portion film 10% of volunteer
Lactic acid solution, the shouting pain degree of test subject in 2min, test result such as table 7.
Standards of grading: no shouting pain 0 divides
Slight shouting pain 1 divides
Moderate shouting pain 2 divides
Severe shouting pain 3 divides
Table 7
As can be seen from Table 7, first group, third group and the 4th group all have the effect of certain alleviation skin sensitivity,
Especially first group and the 4th group of effect it is more obvious, it is sensitive to illustrate that the product of embodiment 3 has effects that alleviate skin.This
Outside, it is compared with first group, the 4th group for second group, the product used lacks calendula extract, albizzia julibrissin extract, okra and mentions
Object is taken, illustrates that said components have a certain effect to skin sensitivity is alleviated.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of crease-resistant tightening cosmetic composition, which is characterized in that including following active component: Radix Angelicae Sinensis, Radix Notoginseng, Astragalus membranacus, radix saposhnikoviae,
Rhizoma Gastrodiae, glossy privet seed, Radix Glycyrrhizae, pot marigold, silk tree, okra, Argireline, acetyl group octapeptide -3, oligopeptides -3 and two palms
Acyl hydroxyproline.
2. crease-resistant tightening cosmetic composition according to claim 1, which is characterized in that the Radix Angelicae Sinensis, Astragalus membranacus, is prevented Radix Notoginseng
Wind, Rhizoma Gastrodiae, glossy privet seed, Radix Glycyrrhizae, pot marigold, silk tree and okra are the extract of corresponding raw material；
In the crease-resistant tightening cosmetic composition, in parts by weight, angelica extract is 1-10 parts, and Radix Notoginseng root extract is 1-10
Part, Astragalus membranaceus extract is 1-12 parts, and Radix Saposhnikoviae extract is 0.5-5 parts, and Rhizoma Gastrodiae extract is 0.5-5 parts, and glossy privet seed extracts
Object is 0.2-4 parts, and licorice is 0.2-4 parts, and calendula extract is 0.2-4 parts, and albizzia julibrissin extract is 0.1-2 parts, yellow
Gumbo extract is 0.1-2 parts, and the Argireline is 0.0001-0.5 parts, and the acetyl group octapeptide -3 is 0.0001-
0.5 part, the oligopeptides -3 is 0.0001-0.5 parts and the dipalmitoyl hydroxyproline is 0.0001-0.5 parts.
3. crease-resistant tightening cosmetic composition of any of claims 1 or 2 is preparing the application in skin care item.
4. a kind of crease-resistant compact lotion, which is characterized in that including crease-resistant tightening cosmetic composition of any of claims 1 or 2, skin care item
Upper acceptable auxiliary material and solvent.
5. crease-resistant compact lotion according to claim 4, which is characterized in that described anti-in the crease-resistant compact lotion
The weight percentage of wrinkle tightening cosmetic composition is 1%-20%.
6. crease-resistant compact lotion according to claim 5, which is characterized in that described to work as in the crease-resistant compact lotion
Return extract, the Radix Notoginseng root extract, the Astragalus membranaceus extract, the glossy privet seed extract and the licorice
The sum of mass percentage be 0.05%-7%；
The mass percentage of the Radix Saposhnikoviae extract, the calendula extract, albizzia julibrissin extract and the Rhizoma Gastrodiae extract
The sum of be 0.05%-6%；
The Abelmoschus Esculentus Linn extract, the Argireline, the acetyl group octapeptide -3, the oligopeptides -3 and two palm
The sum of mass percentage of acyl hydroxyproline is 0.01%-5%.
7. according to the described in any item crease-resistant compact lotions of claim 4-6, which is characterized in that the auxiliary material include: moisturizer,
Anti-sensitizer, thickener, solubilizer and odorant；
The moisturizer be glycerol, Natrulon H-10, glycine betaine, hyaluronic acid, butanediol, propylene glycol, pungent glycol and 1,2- oneself two
One of alcohol is a variety of；
The anti-sensitizer is allantoin；
The thickener is xanthan gum；
The solubilizer is Cremophor RH40；
The odorant is essence.
8. crease-resistant compact lotion according to claim 7, which is characterized in that the moisturizer be glycerol, Natrulon H-10,
The combination of glycine betaine, hyaluronic acid, butanediol, propylene glycol, pungent glycol and 1,2- hexylene glycol；
In the crease-resistant compact lotion, the glycerol is 2%-10%, and the Natrulon H-10 is 1%-4%, the glycine betaine
For 0.1%-2%, the hyaluronic acid is 0.01%-0.1%, and the butanediol is 2%-6%, and the propylene glycol is 1%-
4%, the pungent glycol is 0.2%-0.7%, and 1, the 2- hexylene glycol is 0.1%-0.5%, and the allantoin is 0.01%-
0.1%, the xanthan gum is 0.01%-0.3%, and the Cremophor RH40 is 0.1%-0.3%, and the essence is
0.02-0.1%.
9. the preparation method of the described in any item crease-resistant compact lotions of claim 4-8, which comprises the following steps:
The auxiliary material and solvent are mixed, are uniformly dispersed under conditions of 50 DEG C -90 DEG C, is cooled to 45 DEG C hereinafter, described in addition
Crease-resistant tightening cosmetic composition stirs evenly up to the crease-resistant compact lotion.
10. the preparation method of crease-resistant compact lotion according to claim 8, which comprises the following steps:
By the allantoin, the Natrulon H-10, the glycine betaine and water, stirred evenly under conditions of 65 DEG C -75 DEG C；
The xanthan gum, the hyaluronic acid, the glycerol and the butanediol is added, and is warming up to 82 DEG C -85 DEG C, homogeneous 3-
30 minutes；
42 DEG C -45 DEG C are cooled to, the angelica extract, the Radix Notoginseng root extract, the Astragalus membranaceus extract, institute is added
State glossy privet seed extract, the licorice, the Radix Saposhnikoviae extract, the calendula extract, the albizzia julibrissin extract
With the Rhizoma Gastrodiae extract, stir evenly；
The essence, the propylene glycol, pungent glycol, 1,2- hexylene glycol and Cremophor RH40 is added, stirring to solution is in
Transparence；
Be cooled to 40 DEG C hereinafter, the pH value for adjusting solution to 4-6, be added the Abelmoschus Esculentus Linn extract, the Argireline,
The acetyl group octapeptide -3, the oligopeptides -3 and the dipalmitoyl hydroxyproline stir evenly to get the crease-resistant compact cream
Liquid.
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| CN111568831B (en) * | 2020-06-19 | 2023-02-03 | 上海相宜本草化妆品股份有限公司 | Composition of Chinese herbal medicine extract for skin cosmetics and preparation method thereof |
| CN112604027A (en) * | 2020-12-22 | 2021-04-06 | 北京金莎科技有限公司 | Nutrient solution for comprehensively solving facial collapse |
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Application publication date: 20190329 |