CN109503399B - 一种罗本考昔的制备方法 - Google Patents
一种罗本考昔的制备方法 Download PDFInfo
- Publication number
- CN109503399B CN109503399B CN201811646718.2A CN201811646718A CN109503399B CN 109503399 B CN109503399 B CN 109503399B CN 201811646718 A CN201811646718 A CN 201811646718A CN 109503399 B CN109503399 B CN 109503399B
- Authority
- CN
- China
- Prior art keywords
- tetrafluorophenyl
- reaction
- indol
- water
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811646718.2A CN109503399B (zh) | 2018-12-29 | 2018-12-29 | 一种罗本考昔的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811646718.2A CN109503399B (zh) | 2018-12-29 | 2018-12-29 | 一种罗本考昔的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109503399A CN109503399A (zh) | 2019-03-22 |
CN109503399B true CN109503399B (zh) | 2021-12-24 |
Family
ID=65757135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811646718.2A Active CN109503399B (zh) | 2018-12-29 | 2018-12-29 | 一种罗本考昔的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109503399B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109694330B (zh) * | 2017-10-24 | 2023-10-20 | 乳源瑶族自治县东阳光生物科技有限公司 | 一种酸的制备方法 |
CN110437090A (zh) * | 2019-07-31 | 2019-11-12 | 江苏天和制药有限公司 | 一种罗本考昔三聚体及其制备方法 |
CN112679410A (zh) * | 2019-10-17 | 2021-04-20 | 东莞市东阳光动物保健药品有限公司 | 一种罗本考昔中间体的制备方法 |
CN111807978B (zh) * | 2020-07-29 | 2023-03-14 | 武汉川泰科技有限公司 | 一种罗贝考昔的制备方法 |
WO2023181053A1 (en) | 2022-03-23 | 2023-09-28 | Alivira Animal Health Limited | An improved process for purification of robenacoxib |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1140500C (zh) * | 1997-08-28 | 2004-03-03 | 诺瓦提斯公司 | 某些5-烷基-2-芳基氨基苯乙酸及其衍生物 |
CN102311355A (zh) * | 2011-09-26 | 2012-01-11 | 扬州天和药业有限公司 | 罗本考昔的一种制备方法 |
CN106188190A (zh) * | 2016-07-28 | 2016-12-07 | 威海迪素制药有限公司 | 一种托格列净一水合物的制备方法 |
CN107721901A (zh) * | 2017-11-12 | 2018-02-23 | 刘磊 | 一种2‑[2‑(2,3,5,6‑四氟苯胺基)苯基]乙酸的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2843504C (en) * | 2011-08-12 | 2020-08-25 | Ascendis Pharma A/S | Protein carrier-linked prodrugs |
CN104803956A (zh) * | 2015-03-06 | 2015-07-29 | 江苏天和制药有限公司 | 非罗考昔的一种合成方法 |
-
2018
- 2018-12-29 CN CN201811646718.2A patent/CN109503399B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1140500C (zh) * | 1997-08-28 | 2004-03-03 | 诺瓦提斯公司 | 某些5-烷基-2-芳基氨基苯乙酸及其衍生物 |
CN102311355A (zh) * | 2011-09-26 | 2012-01-11 | 扬州天和药业有限公司 | 罗本考昔的一种制备方法 |
CN106188190A (zh) * | 2016-07-28 | 2016-12-07 | 威海迪素制药有限公司 | 一种托格列净一水合物的制备方法 |
CN107721901A (zh) * | 2017-11-12 | 2018-02-23 | 刘磊 | 一种2‑[2‑(2,3,5,6‑四氟苯胺基)苯基]乙酸的制备方法 |
Non-Patent Citations (3)
Title |
---|
Activity Investigation of Imidazolium-Based Ionic Liquid as Catalyst for Friedel-Crafts Alkylation of Aromatic Compounds;Mingjian Cai,等;《Asian J. Chem》;20150110;第27卷(第2期);第649-653页 * |
Preparation of 1,3,5-Tris(aminomethyl)-2,4,6-triethylbenzene from Two Versatile 1,3,5-Tri(halosubstituted) 2,4,6-Triethylbenzene Derivative;Karl J. Wallace,等;《Synthesis》;20050613;第2005卷(第12期);第2080页Scheme 1,第2082页左栏第2段 * |
罗本考昔合成过程中的副反应研究;刘磊,等;《广东化工》;20201231;第47卷(第15期);第99-101页 * |
Also Published As
Publication number | Publication date |
---|---|
CN109503399A (zh) | 2019-03-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN109503399B (zh) | 一种罗本考昔的制备方法 | |
US7999106B2 (en) | Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form I | |
KR102653443B1 (ko) | 인공 합성 라세미 니코틴 염의 제조 방법 | |
CN111285760A (zh) | 一种贝派地酸的合成方法及中间体 | |
WO2017096772A1 (zh) | 一种抗心衰药lcz696的制备方法 | |
AU2002224131A1 (en) | Process for producing 5-(3-cyanophenyl)-3-formylbenzoic acid compound | |
KR20150040340A (ko) | 인테그라아제 저해제 제조를 위한 방법 및 중간체 | |
TW201912656A (zh) | 舒更葡糖鈉之製備方法及其晶型 | |
CN108218754B (zh) | 一种2-(2,5-二氟苯基)吡咯烷的制备方法 | |
WO2016161956A1 (zh) | 茚达特罗或其盐的制备方法 | |
CN110803980B (zh) | 一锅法制备4-正丁基间苯二酚的方法 | |
CN112062669A (zh) | 芳烃类化合物的制备方法 | |
CN112028874B (zh) | 艾立替尼的合成方法 | |
CN107936045A (zh) | 一种高纯度氟比洛芬已知杂质的制备方法 | |
CN111072450B (zh) | 一种烯丙醇类衍生物的合成方法 | |
CN111269128B (zh) | 1,1′-(六-2,4-二炔-1,6-二基)双(3-烷基脲)类化合物的合成方法 | |
CZ2004416A3 (cs) | Nové bezvodé krystalické formy gabapentinu | |
CN111848487A (zh) | 一种吲哚美辛的纯化方法 | |
CN110642722A (zh) | 一种制备n,n-四甲基癸二胺的方法 | |
CN115417820B (zh) | 一种抗厌氧菌药特硝唑的化学合成方法 | |
CN103857679A (zh) | 制备5-[2-[7-(三氟甲基)-5-[4-(三氟甲基)苯基]吡唑并[1,5-a]嘧啶-3-基]乙炔基]-2-吡啶胺的方法 | |
CN111747850B (zh) | 一锅法合成5-氯-1-氧代-2,3-二氢-1h-茚-2-羧酸甲酯的方法 | |
JPH01186838A (ja) | 3−(4’−ブロモビフェニル)−4−フェニル酪酸の製造方法 | |
JP5083753B2 (ja) | 4,5−ジメチル−[1,3]ジセレノール−2−セロンの新規製造方法 | |
CN110256210B (zh) | 一种1,2,3-三甲氧基-4-苄基苯的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of robbencoxib Effective date of registration: 20220129 Granted publication date: 20211224 Pledgee: Yangzhou Branch of Bank of Jiangsu Co.,Ltd. Pledgor: JIANGSU TIANHE PHARMACEUTICAL CO.,LTD. Registration number: Y2022980001366 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230328 Granted publication date: 20211224 Pledgee: Yangzhou Branch of Bank of Jiangsu Co.,Ltd. Pledgor: JIANGSU TIANHE PHARMACEUTICAL CO.,LTD. Registration number: Y2022980001366 |