CN109481729A - A kind of low molecular weight sodium hyaluronate isotonic liquid dressing and preparation method thereof - Google Patents

A kind of low molecular weight sodium hyaluronate isotonic liquid dressing and preparation method thereof Download PDF

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Publication number
CN109481729A
CN109481729A CN201811403441.0A CN201811403441A CN109481729A CN 109481729 A CN109481729 A CN 109481729A CN 201811403441 A CN201811403441 A CN 201811403441A CN 109481729 A CN109481729 A CN 109481729A
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liquid dressing
sodium hyaluronate
preparation
molecular weight
isotonic
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李秀华
吴兆华
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Nanjing Hua Kai Biotechnology Co Ltd
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Nanjing Hua Kai Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/007—Particle radiation, e.g. electron-beam, alpha or beta radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Abstract

The invention discloses a kind of low molecular weight sodium hyaluronate isotonic liquid dressing and preparation method thereof, and glycerol dilution is added after configuring the aqueous solution of sodium hyaluronate of certain concentration, is configured to isotonic liquid dressing, then sterilized with high irradiation dose.Preparation method of the present invention is simple, still keeps product non-discolouring under high irradiation intensity, can meet large-scale production demand.The dressing simultaneously has isotonic characteristic, the skin that can be used for having wound, and product adjusts osmotic pressure using glycerol, solve sodium chloride adjust the shouting pain of osmotic pressure externally applied product bring, it is dry after use the disadvantages of.

Description

A kind of low molecular weight sodium hyaluronate isotonic liquid dressing and preparation method thereof
Technical field
The present invention relates to hyaluronic acid product fields, relate in particular to a kind of low molecular weight sodium hyaluronate isotonic liquid Dressing and preparation method thereof.
Background technique
Sodium Hyaluronate be it is a kind of can be found in all vertebrate organs and blood, and in the thin of soft connective tissue Widely distributed acid mucopolysaccharide in extracellular matrix (ECM).Hyaluronic acid has height viscoplasticity, plasticity, superpower water holding Property, permeability and the good easy absorbability of biology, are widely used in fields such as cosmetics, medicine, food.Because thoroughly Molecular weight is directly related corresponding thereto for the bioactivity and using effect of bright matter acid sodium, thus should according to the difference for using purpose, Select suitable molecular weight.Such as: the Sodium Hyaluronate of high molecular weight works as Mr > 2 × 106The HA of Da have preferable viscoplasticity, Moisture retention inhibits the functions such as inflammatory reaction, lubrication, can be used for the open-minded bullet agent of ophthalmologic operation and intra-articular injection therapy；Mr is in (1- 2) ×106The HA of Da has good moisture retention, lubrication and medicament slow release effect, can be widely used for cosmetics, eye drops, skin Skin burn-healing and post-operation adhesion preventing；Mr is at (1-8) × 104Low molecular weight sodium hyaluronate and Mr < 1 × 10 between Da4Da HA oligosaccharide, have it is antitumor, promote wound healing, promote bone and the effects of angiogenesis, immunological regulation.
At present because micromolecule hyaluronic acid sodium preparation method is complicated, higher cost, external application Sodium Hyaluronate product multiselect is used High molecular weight sodium hyaluronate.Patent No. ZL 201210317032.5 discloses that " enzyme cutting method prepares the side of oligomerization hyaluronate Method ", this method is there are hyaluronic acid enzyme source is less, and expensive, cost is high, is difficult to control the palliating degradation degree of molecular weight； The functional activity of enzyme preparation product is unstable, causes subsequent technique condition (temperature, pH value etc.) to need to debug repeatedly, increases life Produce difficulty；Enzyme after reaction will also carry out the disadvantages of inactivation and separating treatment, be not suitable for industrialized production.Chinese patent application (application number 201610072524.0) discloses " a kind of method that electron beam irradiation prepares low molecular weight hyaluronic acid ", this method by It sterilizes in using high intensity radiation, the micromolecule hyaluronic acid sodium color of preparation is deeper, and domestic and international client produces this method Low-numerator sodium hyaluronate degree of recognition it is lower, market is relatively narrow.
Chinese patent CN107149688 discloses a kind of sterile production method of hyalomitome acids product, is first added It is irradiated again after the preservative (potassium sorbate, sodium benzoate or parabens) of 0.01%-0.5%wt, irradiation dose 6- 10kGy.The irradiation dose of the prior art is not high, therefore requires height to production environment, once improving irradiation dose, will lead to product Colour changed into yellow influences product quality.On the other hand, the hyaluronic acid product of the prior art does not have isotonic feature, using in flesh It needs to cooperate sodium chloride isotonic solution on skin or wound, is easy to bring tingling sensation, and be easy drying after use.
Summary of the invention
Goal of the invention: the object of the present invention is to provide a kind of low molecular weight sodium hyaluronate isotonic liquid dressing and its preparations Method.
Technical solution: in order to achieve the above-mentioned object of the invention, preparation method of the invention includes the following steps:
(1) aqueous solution of sodium hyaluronate is configured；
(2) glycerol is added；
(3) 60Coradiation sterilizing or electron beam sterilization；
(4) it is diluted to the liquid dressing of osmotic pressure 270-320 mOsmol/L.
Further, in the aqueous solution of sodium hyaluronate, 0.01 wt% -5.0 wt% of hyaluronic acid na concn, glycerol 0.1 wt% -20 wt% of concentration.Isotonic liquid dressing is prepared in order to facilitate dilution, the glycerol concentration is preferably 2 wt%- 20 wt%, more preferably 2 wt% -10 wt% can also be with.
Irradiation sterilization is preferably sterilized with 60Coradiation, irradiation dose 11kGy-100kGy.Preferably, the irradiation sterilization Irradiation dose be 20kGy-50kGy.The present invention improves irradiation dose, and is protected since glycerol is added, so that irradiation Transparent procedures matter acid still keeps Transparent color.
Institute's liquid dressing liquid further includes thickener, and the thickener includes but is not limited to carbomer, xanthan gum, ethoxy fibre The combination of dimension element, any one or kind in carboxymethyl cellulose.Preferably any one of carbomer, xanthan gum.
Institute's liquid dressing liquid further includes preservative, and the preservative includes but is not limited to methyl p-hydroxybenzoate, to hydroxyl Yl benzoic acid methyl esters sodium, ethyl-para-hydroxybenzoate, P-hydroxybenzoic acid second sodium, propylparaben, para hydroxybenzene first Sour third sodium, chlorobenzene glycosides ether, methylchloroisothiazandnone, methylisothiazolinone, bis- (carboxymethyl) imidazolidinyl ureas, benzoic acid, Sodium benzoate, sorbic acid, potassium sorbate, benzyl alcohol, benzyl carbinol, phenylpropanol, decoyl hydroximic acid, parahydroxyacet-ophenone, pentanediol, The combination of any one or more of pungent glycol.Preferably using methyl p-hydroxybenzoate, Sodium Methyl Hydroxybenzoate, right Nipagin A, P-hydroxybenzoic acid second sodium, propylparaben, the third sodium of P-hydroxybenzoic acid, chlorobenzene glycosides ether, benzene Any one of sodium formate, sorbic acid, potassium sorbate.
Further, EDTA-2Na can be also added in institute's liquid dressing liquid, be used for chelated metal ions.
A kind of low-molecular-weight hyaluronic acid isotonic liquid dressing, including following component: 0.01 wt%- of hyaluronic acid na concn 5.0 wt%, 0.1 wt% -50 wt% of glycerol concentration, remaining is water.
As a preferred solution of the present invention, a kind of hyaluronic acid isotonic liquid dressing, including following component: Sodium Hyaluronate 0.01 wt% -5.0 wt% of concentration, 0.1 wt% -20 wt% of glycerol concentration, thickener be carbomer or xanthan gum, remaining For water.Even if the present invention is added without preservative, also can achieve the effect that.
The osmotic pressure of the hyaluronic acid isotonic liquid dressing is 270-320 mOsmol/L, and product clear uses Platinum-cobalt method is no more than 70 degree, preferably more than 60 degree than chroma color.
The utility model has the advantages that the method for the isotonic dressing of micromolecule hyaluronic acid sodium of the invention, preparation method is simple, irradiates in height Color is still remained unchanged under intensity, can meet large-scale production demand.The dressing simultaneously has isotonic characteristic, can be used for wound Skin, product adjusts osmotic pressure using glycerol, solves sodium chloride and adjust the shouting pain of osmotic pressure externally applied product bring, after use The disadvantages of dry.
Specific embodiment
Embodiment 1
Glycerol 2.1g, Sodium Hyaluronate 2g add water 96.9ml to be configured to homogeneous aqueous solution, 40kGy 60Coradiation after sealing, obtain Low molecular weight sodium hyaluronate isotonic liquid dressing.
This handicraft product viscosity is larger, about 1800 mPa.s, product clear, compares chroma color using platinum-cobalt method About 60 degree, osmotic pressure 295mOsmol/L.
The product is sterile product.It can be used for smearing problem skin or spread on wound.Smearing problem skin relatively contains chlorination The mild moisturizing of the product of sodium can reduce inflammatory reaction, promote skin metabolism；For wound compared with the product hydration energy containing sodium chloride Power is stronger, can promote wound healing.
Embodiment 2
Glycerol 11g, Sodium Hyaluronate 2g add water 88ml to be configured to homogeneous aqueous solution, 50kGy 60Coradiation after sealing.Then it takes The above-mentioned solution of 20ml, is added 0.2g nipagin A sodium, 0.1g Sodium Methyl Hydroxybenzoate, and 0.1g carbomer stirs It mixes uniformly, is settled to 100ml, dispenses after mixing evenly.
This handicraft product viscosity is about 1500 mPa.s, and product clear is about than chroma color using platinum-cobalt method 50 degree, osmotic pressure is 290 mOsmol/L.
The product is non-sterile product.It can be used for smearing problem skin, be used for small-sized non-chronic wounds.Smearing problem skin Compared with the mild moisturizing of the product containing sodium chloride, inflammatory reaction can reduce, promote skin metabolism；Relatively contain for small-sized non-chronic wounds There is the product hydratability of sodium chloride stronger, can promote wound healing.
Embodiment 3
Glycerol 30g, Sodium Hyaluronate 3g add water 67ml to be configured to homogeneous aqueous solution, 50kGy 60Coradiation after sealing.8ml is above-mentioned In solution, 0.12g methyl p-hydroxybenzoate is added, 0.15g chlorobenzene glycosides ether, 0.1g xanthan gum stirs evenly, be settled to 100ml is dispensed after mixing evenly.
This handicraft product viscosity is about 1500 mPa.s, and product clear is about than chroma color using platinum-cobalt method 60 degree, osmotic pressure is 310 mOsmol/L.
The product is non-sterile product.It can be used for smearing problem skin, be used for small-sized non-chronic wounds.Smearing problem skin Compared with the mild moisturizing of the product containing sodium chloride, inflammatory reaction can reduce, promote skin metabolism；Relatively contain for small-sized non-chronic wounds There is the product hydratability of sodium chloride stronger, can promote wound healing.
Embodiment 4
Glycerol 40g, Sodium Hyaluronate 3g add water 57ml to be configured to homogeneous aqueous solution, 50kGy 60Coradiation after sealing.It takes on 6ml It states solution, is added 0.5g Phenoxyethanol, 0.15g sodium benzoate, 0.1g benzyl alcohol, 0.1g xanthan gum stirs evenly, be settled to 100ml is dispensed after mixing evenly.
This handicraft product viscosity is larger, about 1500 mPa.s, product clear, compares chroma color using platinum-cobalt method About 60 degree, osmotic pressure is 310 mOsmol/L.
Embodiment 5
Glycerol 10g, Sodium Hyaluronate 1g add water 89ml to be configured to homogeneous aqueous solution, 30kGy 60Coradiation after sealing.Take 25ml Above-mentioned solution, is added 0.1g decoyl hydroximic acid, 0.2g parahydroxyacet-ophenone, and 0.01gEDTA-2Na is stirred evenly, is settled to 100ml is dispensed after mixing evenly.
This handicraft product viscosity is larger, about 300 mPa.s, product clear, compares chroma color using platinum-cobalt method About 40 degree, osmotic pressure is 315 mOsmol/L.
The product is non-sterile product.It can be used for smearing problem skin, be used for small-sized non-chronic wounds.Smearing problem skin Compared with the mild moisturizing of the product containing sodium chloride, inflammatory reaction can reduce, promote skin metabolism；Relatively contain for small-sized non-chronic wounds There is the product hydratability of sodium chloride stronger, can promote wound healing.
Embodiment 6
Glycerol 20g, Sodium Hyaluronate 2g add water 78ml to be configured to homogeneous aqueous solution, 45kGy 60Coradiation after sealing.Take 10ml Above-mentioned solution, 2% pentanediol of addition, the pungent glycol of 0.2g, 0.1g methylisothiazolinone, 0.1g carboxymethyl cellulose stir evenly, It is settled to 100ml, is dispensed after mixing evenly.
This handicraft product viscosity is larger, about 1200 mPa.s, product clear, compares chroma color using platinum-cobalt method About 40 degree, osmotic pressure is 285 mOsmol/L.
The product is non-sterile product.It can be used for smearing problem skin, be used for small-sized non-chronic wounds.Smearing problem skin Compared with the mild moisturizing of the product containing sodium chloride, inflammatory reaction can reduce, promote skin metabolism；Relatively contain for small-sized non-chronic wounds There is the product hydratability of sodium chloride stronger, can promote wound healing.
Comparative experimental example 1
Sodium Hyaluronate 2g adds water 98ml to be configured to homogeneous aqueous solution, 40kGy 60Coradiation after sealing, and it is saturating to obtain low molecular weight Bright matter acid sodium liquid dressing.
This handicraft product viscosity is smaller, about 200 mPa.s, and the micro- Huang of product is about than chroma color using platinum-cobalt method 200 degree, osmotic pressure 3mOsmol/L.
The product be sterile product, color be it is faint yellow, infiltration is forced down, and be can be used for smearing problem skin or is spread on wound.
Comparative experimental example 2
Sodium Hyaluronate 1g adds water 99ml to be configured to homogeneous aqueous solution, 30kGy 60Coradiation after sealing.The above-mentioned solution of 25ml is taken, 0.1g decoyl hydroximic acid, 0.2g parahydroxyacet-ophenone is added, 0.01gEDTA-2Na is stirred evenly, and is settled to 100ml, and stirring is equal Packing after even.
This handicraft product viscosity is smaller, about 50 mPa.s, the micro- Huang of product colour, about than chroma color using platinum-cobalt method It is 100 degree, osmotic pressure is 315 mOsmol/L.
The product is non-sterile product.It can be used for smearing problem skin, be used for small-sized non-chronic wounds.
It can be seen that the hyaluronic acid aqueous solution of same concentrations in spoke from the comparison of above-described embodiment 1 and comparative experimental example 1 Product yellowing problems caused by can significantly reducing according to preceding addition glycerol because of high irradiation intensity.It can from embodiment 5 and test example 2 Out, the glycerol protection hyaluronic acid aqueous solution that can be previously added high concentration carries out irradiation sterilization, is then diluted to for five times Osmometer solution can also be obviously improved the problem of product turns yellow for being added without the isotonic solution of glycerol acquisition.

Claims (10)

1. a kind of preparation method of low molecular weight sodium hyaluronate isotonic liquid dressing, it is characterised in that include the following steps:
(1) aqueous solution of sodium hyaluronate is configured；
(2) glycerol is added；
(3) 60Coradiation sterilizing or electron beam sterilization；
(4) it is diluted to the liquid dressing of osmotic pressure 270-320 mOsmol/L.
2. a kind of preparation method of low molecular weight sodium hyaluronate isotonic liquid dressing according to claim 1, feature It is: in the aqueous solution of sodium hyaluronate, hyaluronic acid na concn 0.01 wt% -5.0 wt%, 0.1 wt% of glycerol concentration - 20 wt%。
3. a kind of preparation method of low molecular weight sodium hyaluronate isotonic liquid dressing according to claim 1, feature Be: the irradiation dose of the irradiation sterilization is 11kGy-100kGy.
4. a kind of preparation method of low molecular weight sodium hyaluronate isotonic liquid dressing according to claim 3, feature Be: the irradiation dose of the irradiation sterilization is 20kGy-50kGy.
5. a kind of preparation of low molecular weight sodium hyaluronate isotonic liquid dressing according to any one of claims 1 to 4 Method, it is characterised in that: institute's liquid dressing liquid further includes thickener, and the thickener is carbomer, xanthan gum, hydroxy ethyl fiber The combination of element, any one or kind in carboxymethyl cellulose.
6. a kind of preparation method of low molecular weight sodium hyaluronate isotonic liquid dressing according to claim 5, feature Be: institute's liquid dressing liquid further includes preservative, and the preservative includes methyl p-hydroxybenzoate, methyl p-hydroxybenzoate Sodium, ethyl-para-hydroxybenzoate, P-hydroxybenzoic acid second sodium, propylparaben, the third sodium of P-hydroxybenzoic acid, chlorobenzene glycosides Ether, methylchloroisothiazandnone, methylisothiazolinone, bis- (carboxymethyl) imidazolidinyl ureas, benzoic acid, sodium benzoate, sorb Acid, potassium sorbate, benzyl alcohol, benzyl carbinol, phenylpropanol, decoyl hydroximic acid, parahydroxyacet-ophenone, pentanediol, pungent glycol it is any One or more combinations.
7. a kind of preparation method of low molecular weight sodium hyaluronate isotonic liquid dressing according to claim 6, feature Be: institute's liquid dressing liquid further includes EDTA-2Na.
8. a kind of low-molecular-weight hyaluronic acid isotonic liquid dressing, it is characterised in that including following component: bright matter acid na concn 0.01 wt%-5.0 wt%, 0.1 wt%-50 wt% of glycerol concentration, remaining is water.
9. a kind of low-molecular-weight hyaluronic acid isotonic liquid dressing according to claim 8, it is characterised in that including as follows Component: bright 0.01 wt%-5.0% of matter acid na concn, glycerol concentration 0.1 wt% -20 wt%, thickener 0-5 wt%, preservative 0.1 wt% -5 wt%, remaining is water.
10. a kind of low-molecular-weight hyaluronic acid isotonic liquid dressing according to claim 9, it is characterised in that: osmotic pressure For 270-320 mOsmol/L.
CN201811403441.0A 2018-11-23 2018-11-23 A kind of low molecular weight sodium hyaluronate isotonic liquid dressing and preparation method thereof Pending CN109481729A (en)

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CN107519495A (en) * 2017-09-11 2017-12-29 南京华开生物科技有限公司 Application of the glycerine in protection carbomer solution irradiation stability
CN109939256A (en) * 2019-04-01 2019-06-28 南京华开生物科技有限公司 A kind of asymmetric dressing for skin and preparation method thereof
CN110522942A (en) * 2019-10-16 2019-12-03 浙江星月生物科技股份有限公司 A kind of preparation method of skin repair dressing and skin repair dressing
CN111790003A (en) * 2020-08-27 2020-10-20 哈尔滨工业大学 Liquid wound dressing for promoting rapid repair of skin injury and preparation method thereof
CN112107721A (en) * 2020-10-22 2020-12-22 伊索曼(中山)医疗器械有限公司 Synthetic dressing with biological effect and preparation method thereof
CN114306185A (en) * 2021-12-31 2022-04-12 广州市瑞芬化妆品有限公司 Anti-photochromic composition and preparation method thereof, and whitening and anti-wrinkle essence and preparation method thereof

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