CN109463384A - A kind of bactericidal composition containing Thymol and Boscalid - Google Patents
A kind of bactericidal composition containing Thymol and Boscalid Download PDFInfo
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- CN109463384A CN109463384A CN201811335819.8A CN201811335819A CN109463384A CN 109463384 A CN109463384 A CN 109463384A CN 201811335819 A CN201811335819 A CN 201811335819A CN 109463384 A CN109463384 A CN 109463384A
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- boscalid
- thymol
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- composition pesticide
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition and application thereof containing Thymol and Boscalid, wherein the mass ratio of Thymol and Boscalid is 1~20:1~20, total mass fraction of the effective component in bactericidal composition is 10%~42%, the dosage form of composition pesticide is missible oil, there is obvious synergistic function between bactericidal composition effective component of the invention, compounding agent effective component usage amount is significantly reduced than single dose, the prevention and treatment suitable for corn, eliminating vegetable botrytis.
Description
Technical field
The present invention relates to fungicide fields, specifically using Thymol and Boscalid as the Bactericidal composite of effective component
Object, suitable for preventing and treating the gray mold microbial by Botrytis cinerea.
Technical background
The pathogen of Botrytis cinerea (Botrytis cinerea) it is common plant pathogenic fungi, corn, vegetables etc. can be caused to make
The gray mold of object.It is extremely extensive that the germ infects range, and pathogenecity is strong, can infect in each growth period of crop；Together
When, has the characteristics that infectious, and conidium can pass through air borne；Harm is serious, once large area generation will will cause work
The object underproduction, or even total crop failure.Currently, the medicament for preventing and treating gray mold is based on chemical pesticide single dose, it is long-term largely to use band
The problems such as coming drug resistance, environmental pollution, research and development efficiently, the novel germicide composition of low toxicity, safety be doing of solving these problems
One of method.
Thymol, English name: Thymol, chemical name: -5 methylphenol of 2- isopropyl is a kind of Monoterpene phenols
Compound.Thymol Lippia (Lippia), Thymus (Thymus), savoury category (Satureja) and Origanum
(Origanum) plant in content it is higher.Thymol has the characteristics that low toxicity, environmental-friendly as a kind of natural component,
Have the pathogen of Botrytis cinerea compared with high bacteriostatic activity and is not likely to produce drug resistance.Its structural formula is as follows:
Boscalid, English common name: boscalid, chemical name: the chloro- N- of 2- (4 '-chlorodiphenyl -2- base) niacinamide is a kind of
Systemic fungicide can be used for preventing and treating crop gray mold, powdery mildew, sclerotiniose and root rot.Boscalid is a kind of succinic acid
Ubiquinone reductase inhibitor, by hindering tricarboxylic acid cycle that fungus spore germination, mycelia is inhibited to grow.Its structural formula is as follows:
The effective component of different role mechanism is subjected to the common method that compounding is agricultural chemicals research and development.Currently, there is not yet with hundred li
The report of fragrant phenol and Boscalid composition for preventing and controlling crop gray mold.
Summary of the invention
The purpose of the present invention is in view of the above deficiencies, provide it is a kind of be suitble to agriculturally use, crop gray mold is prevented and treated
Effect is good, and low toxicity, environmental-friendly microbicide compositions.
The invention is realized by the following technical scheme:
A kind of effective component is the composition pesticide of Thymol and Boscalid, the mass ratio of Thymol and Boscalid
For 1~20:1~20, preferred mass ratio is 1~20:1~4.
Specific formula includes: to be made of by mass percentage following substance, 8 % of Thymol, 2 % of Boscalid, agriculture breast
10 % of 600#, remaining is dimethylbenzene.
Specific formula includes: to be made of by mass percentage following substance, 40 % of Thymol, 2 % of Boscalid, agriculture breast
10 % of 600#, remaining is dimethylbenzene.
This bactericidal composition can be processed as the missible oil for being suitble to agriculturally use with Pesticide formulation art-known methods,
Gross mass percentage composition of the effective component in bactericidal composition is the % of 10 %~42.
The adjuvant that composition process preparation of the invention uses includes dispersing agent, wetting agent, antifreezing agent etc. and other has
It beneficial to the effective component known substance that stable and drug effect plays in storage and use, is commonly used or allows in pesticidal preparations
The various composition used, is not particularly limited.
Compared with prior art, the present invention has following technical effect that
The present invention is for the first time by Thymol and Boscalid compounded combination, compared with single dose, between the bactericidal composition effective component
For synergistic function, control efficiency is improved.And chemical synthesis effective ingredient consumption is greatly decreased, reduce pesticide residue and
Environmental pollution.Thymol is different with the Boscalid mechanism of action, and compounded combination can delay the generation of drug resistance, be conducive to prolong
Long fungicide service life.
Specific embodiment
To better understand the essence of the present invention, be described further by following embodiment, but the present invention and unlimited
In these embodiments.In these embodiments, unless otherwise stated, all percentages are mass percent.
Example of formulations 1:10 % Thymol Boscalid missible oil
[8 % of Thymol is weighed by mass percentage, Boscalid 10 % of 2 %, agriculture breast 600#, remaining is dimethylbenzene.It will be upper
It states after formula stirs and evenly mixs in proportion and obtains 10 % Thymol Boscalid missible oil.
Example of formulations 2:42 % Thymol Boscalid missible oil
40 % of Thymol is weighed by mass percentage, and Boscalid 10 % of 2 %, agriculture breast 600#, remaining is dimethylbenzene.It will be upper
It states after formula stirs and evenly mixs in proportion and obtains 42 % Thymol Boscalid missible oil.
Assays Example 1: the indoor toxicity test of Thymol and Boscalid composition to the pathogen of Botrytis cinerea
Test method: first weighing the effective component of certain mass, and the Tween 80 water that acetone uses 0.1 % after completely dissolution is added
Solution dilution, is configured to single dose mother liquor respectively, respectively with 20:1,10:1,4:1,3:2,2:3,1:4,1:10,1:20 proportion.Ginseng
According to NY/T 1156.6-2006 " the 6th part of farm-chemical indoor determination test rule fungicide: mixed synergy measurement "
Method with mycelial growth rate method measurement various concentration composition bacteriostasis rate.
Using the logarithm of drug concentration (μ g/ml) as independent variablex, using the probit value of inhibiting rate as dependent variabley, establish respectively
Virulence regression equation calculates single dose using DPS software and respectively matches tear agentEC 50(95 % confidence limit) and use Sun Yun
Abundant method calculates the co-toxicity coefficient (CTC) of mixture.
According to the NY/T 1156.6-2006 fungicide synergy criteria for classifying: co-toxicity coefficient (CTC) >=120 performance
For synergistic function；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 < co-toxicity coefficient (CTC) < 120
Show as summation action.
The The Toxicity Determination result of 1 Thymol of table and Boscalid composition to the pathogen of Botrytis cinerea
| Medicament | Virulence regression equation | EC 50 | Confidence interval (95%) | Co-toxicity coefficient |
| Boscalid (A) | y = 1.430 x - 0.480 | 2.166 | 1.487-2.823 | / |
| Thymol (B) | y = 3.593 x - 3.978 | 12.801 | 11.429-14.715 | / |
| A:B=1:20 | y = 1.510 x - 0.412 | 1.874 | 1.465-2.286 | 553.639 |
| A:B=1:10 | y = 1.447 x - 0.347 | 1.738 | 0.557-2.938 | 509.234 |
| A:B=1:4 | y = 1.818 x - 0.742 | 2.559 | 2.149-2.996 | 252.390 |
| A:B=2:3 | y = 1.502 x - 0.450 | 1.993 | 0.731-3.360 | 216.701 |
| A:B=3:2 | y = 1.365 x - 0.324 | 1.728 | 0.555-2.925 | 187.735 |
| A:B=4:1 | y = 1.243 x - 0.320 | 1.808 | 1.322-2.296 | 143.674 |
| A:B=10:1 | y = 1.224 x - 0.358 | 1.962 | 1.448-2.484 | 119.417 |
| A:B=20:1 | y = 1.182 x - 0.422 | 2.276 | 1.703-2.874 | 99.087 |
As seen from the results in Table 1, Thymol and Boscalid are bright with 20:1,10:1,4:1,3:2,2:3,1:4 mixed synergies
Aobvious, co-toxicity coefficient is greater than 140, and Thymol and Boscalid are using 1:10 mixture as summation action, Thymol and Boscalid
Using 1:20 mixture as antagonism.
Control efficiency of the Assays Example 2:10 % Thymol Boscalid missible oil to graw mold of tomato
This test is carried out on October 9th, 2018 in Yunnan Province, Panlong District, Kunming dragon's fountain street peach garden village, by 10 % thymes
Phenol Boscalid missible oil, is watered that be diluted to 200,400 and 800 times of liquid spraying respectively, after 7 d preventive effect be respectively 79.7%,
74.6% and 67.3%；With 50% Boscalid water dispersible granules (Kai Ze®BASF European Co., Ltd) 2000 times of liquid are control, it uses
Same application method, preventive effect is respectively 72.5% after 7 d.Under Isodose (in terms of active constituent content), the effect of composition is excellent
In single dose.
Assays Example 3:42 % Thymol Boscalid missible oil is to corn Botrytis cinerea ear rot (corn ash
Mildew) control efficiency
This test is carried out on October 12nd, 2018 in Yunnan Province, Panlong District, Kunming dragon's fountain street peach garden village, by 42 % thymes
Phenol Boscalid missible oil, be watered respectively be diluted to 800,1600 and 2000 times of liquid sparge by artificial mechanism damage fresh jade
Rice fringe surface is inoculated with the pathogen of Botrytis cinerea after 24 h, and preventive effect is respectively 94.5 %, 88.6 % and 82.9 % after 7 d；With 50 % pyridine acyls
Bacterium aqueous amine dispersible granule (Kai Ze®BASF European Co., Ltd) 2000 times of liquid are control, using same test method, preventive effect after 7 d
Respectively 86.5 %.Under Isodose (in terms of active constituent content), the effect of composition is better than single dose.
In conclusion Thymol and Boscalid composition of the invention are to the microbial corn of Botrytis cinerea, vegetables
Gray mold has good control efficiency, compared with single dose, reduces the dosage of chemical synthesis effective component.In addition, the combination
Object tests process without obvious phytotoxicity situation to crop safety.Therefore, the present invention has great application and popularization value.
Claims (6)
1. a kind of composition pesticide containing Thymol and Boscalid, it is characterised in that: effective component is Thymol and pyridine
Acyl bacterium amine.
2. the composition pesticide of Thymol according to claim 1 and Boscalid, it is characterised in that: Thymol and
Mass ratio of the Boscalid in composition pesticide is 1~20:1~20.
3. the composition pesticide of Thymol according to claim 1 or 2 and Boscalid, it is characterised in that: thyme
The total mass fraction of phenol and Boscalid in composition pesticide is the % of 10 %~42.
4. Thymol according to claim 3 and Boscalid composition pesticide, it is characterised in that: the pesticide group
The dosage form for closing object is missible oil.
5. the composition pesticide of the Thymol and Boscalid that require according to claim 1, which is characterized in that be suitable for prevention and treatment
By the microbial crop gray mold of Botrytis cinerea.
6. the purposes of bactericidal composition according to claim 5, which is characterized in that its applicable crops are corn, vegetables.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811335819.8A CN109463384A (en) | 2018-11-11 | 2018-11-11 | A kind of bactericidal composition containing Thymol and Boscalid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811335819.8A CN109463384A (en) | 2018-11-11 | 2018-11-11 | A kind of bactericidal composition containing Thymol and Boscalid |
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| CN109463384A true CN109463384A (en) | 2019-03-15 |
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| CN201811335819.8A Pending CN109463384A (en) | 2018-11-11 | 2018-11-11 | A kind of bactericidal composition containing Thymol and Boscalid |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111345297A (en) * | 2020-04-08 | 2020-06-30 | 广西壮族自治区亚热带作物研究所（广西亚热带农产品加工研究所） | Pesticide composition for preventing and treating pineapple black rot |
| CN115590027A (en) * | 2022-09-20 | 2023-01-13 | 贵州省生物技术研究所（贵州省生物技术重点实验室、贵州省马铃薯研究所、贵州省食品加工研究所）（Cn） | Tebuconazole and thymol compounded konjak root rot resistant bactericidal composition |
| CN116019116A (en) * | 2022-12-07 | 2023-04-28 | 四川易宏欣农业科技有限公司 | Pesticide powder and application method thereof |
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| CN106962341A (en) * | 2017-04-12 | 2017-07-21 | 江苏金凤凰农化有限公司 | A kind of composition and application process that graw mold of tomato is treated based on guaiacol |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111345297A (en) * | 2020-04-08 | 2020-06-30 | 广西壮族自治区亚热带作物研究所（广西亚热带农产品加工研究所） | Pesticide composition for preventing and treating pineapple black rot |
| CN111345297B (en) * | 2020-04-08 | 2022-02-11 | 广西壮族自治区亚热带作物研究所（广西亚热带农产品加工研究所） | Pesticide composition for preventing and treating pineapple black rot |
| CN115590027A (en) * | 2022-09-20 | 2023-01-13 | 贵州省生物技术研究所（贵州省生物技术重点实验室、贵州省马铃薯研究所、贵州省食品加工研究所）（Cn） | Tebuconazole and thymol compounded konjak root rot resistant bactericidal composition |
| CN116019116A (en) * | 2022-12-07 | 2023-04-28 | 四川易宏欣农业科技有限公司 | Pesticide powder and application method thereof |
| CN116019116B (en) * | 2022-12-07 | 2024-01-12 | 孟州农达生化制品有限公司 | Pesticide powder and application method thereof |
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