CN109394969A - A kind of reinforcing both QI and YIN, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution and preparation method thereof - Google Patents
A kind of reinforcing both QI and YIN, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
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Abstract
The present invention relates to technical field of Chinese medicine, and in particular to a kind of reinforcing both QI and YIN, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution and preparation method thereof.The beverage effective component is prepared from the following materials: longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, Radix Glycyrrhizae.Using longan, fructus lycii as monarch drug in a prescription；Chinese yam, rhizoma polygonati are ministerial drug；Rose, mulberries, jujube, Radix Glycyrrhizae are adjuvant, have reinforcing both QI and YIN, the effect of strengthening the body resistance to consolidate the constitution.It exaggerates for postpartum overstrain, the symptoms such as dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation.The present invention selects pressure difference solvent fluid broken wall+continuous gradient molecule sieving repeatedly+low temperature to be concentrated and dried the integrated abstraction technique combination such as crystallization+on-line near infrared spectroscopy analysis, the harmful and invalid components such as heavy metal, agriculture is residual, change is residual, impurity are screened out to greatest extent, and are efficiently kept completely separate extraction active constituent.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of reinforcing both QI and YIN, the food and medicament dual-purpose strengthened the body resistance to consolidate the constitution combination
Object and preparation method thereof.
Background technique
Overexertion when puerpera is because of childbirth, excessive blood loss in birth process in addition, it is easy to cause the deficiency of blood, the performance of the deficiency of blood
Mainly pale complexion, when have it is dizzy, if simultaneously with the deficiency of vital energy, that is, it is qi-blood deficiency, it is weak, lazy to there is also whole body
Speech, loss of appetite, resistance decline, have seriously affected health, if situation cannot improve, it is more likely that generate
Many complication.And then uterus recovery is also influenced, and will affect mood and lactation, cause a series of postpartum problems.Clinically
It is usually necessary to use oral drugs to carry out symptomatic treatment, mainly for the tonic of the chronic diseases marked by deficiency of vital energy, lacks whole nourish and improves；In addition female
Sub- postpartum health control lacks, and causes to be easy to appear the common postpartum disease such as the deficiency of vital energy, deficiency of blood, also there is the special physiologicals such as woman menstruation
Symptoms and the mood changes such as the problems such as period also can be because of endocrine leader is dizzy, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation are
Alleviate these symptoms and generally also may require that and carries out symptomatic treatment using oral drugs.
Although also occur on the market now it is some for women special physiological period or postpartum dizziness, palpitaition, it is lazy say,
The oral drugs of the symptoms such as burnout, dry, night sweat dysphoria with smothery sensation, but these product one side effects are relatively simple, such as main hair
It waves tonifying Qi, enrich blood or tonifying yin, yang-tonifying effect, there are certain side effect, there are also extract oral products to be used for postpartum qi and blood
The symptoms such as weakness, less effective work slower, lack the Orally taken product with multiple comprehensive health-care effect；On the other hand, existing
Extract oral product exist formula is excessively complicated, chemical assistant content is higher, technology content is lower, quality matte, activity at
It is point indefinite, impurity composition is higher, sanitary standard is lower, security quality causes anxiety, cost is also higher equal obvious insufficient.It is especially big
Most taste scent experiences are poor, it is difficult to adhere to taking.Urgently there is upgraded product to meet mainstream consumer group of new generation quick
The market of growth just needs.
Summary of the invention
In order to overcome prior art defect, the object of the present invention is to provide a kind of reinforcing both QI and YINs, the food of effect of strengthening the body resistance to consolidate the constitution
The dual-purpose molecular level composition of medicine, is exaggerated with rapid recovery postpartum overstrain, dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, the heart
Throb with fear, symptoms, the pure natural active that can be used as women postpartum and special physiological period such as lazy speech, burnout, dry, night sweat dysphoria with smothery sensation are pacified
Full Orally administered composition.
Further, the present invention also reside in provide a kind of reinforcing both QI and YIN, effect of strengthening the body resistance to consolidate the constitution food and medicament dual-purpose composition system
Preparation Method, can be improved the extraction of raw material pharmaceutically active ingredient and the quality of application efficiency and product, and product meets higher health
Standard can reach organic food-grade quality, and the safe drink of women for being more in line with the special physiological phase just needs.
In order to achieve the goal above, the technical scheme adopted by the invention is that:
A kind of food and medicament dual-purpose composition for having effects that reinforcing both QI and YIN, strengthening the body resistance to consolidate the constitution, effective component is by following parts by weight
Raw material is prepared: 5~30 parts of longan, 5~30 parts of fructus lycii, 5~30 parts of Chinese yam, 5~25 parts of rhizoma polygonati, 5~20 parts of rose,
5~30 parts of mulberries, 5~25 parts of jujube, 5~15 parts of Radix Glycyrrhizae.
Preferably, the above-mentioned food and medicament dual-purpose composition article for having effects that reinforcing both QI and YIN, strengthening the body resistance to consolidate the constitution, effective component by
The raw material of following parts by weight is prepared: 10~20 parts of longan, 10~20 parts of fructus lycii, 10~20 parts of Chinese yam, rhizoma polygonati 10~
20 parts, 5~10 parts of rose, 10~20 parts of mulberries, 10~20 parts of jujube, 5~10 parts of Radix Glycyrrhizae.
It is further preferred that the above-mentioned food and medicament dual-purpose composition for having effects that reinforcing both QI and YIN, strengthening the body resistance to consolidate the constitution, effective component
Be prepared by following raw material in parts by weight: 15 parts of longan, 15 parts of fructus lycii, 15 parts of Chinese yam, 13 parts of rhizoma polygonati, 7 parts of rose,
15 parts of mulberries, 13 parts of jujube, 7 parts of Radix Glycyrrhizae.
It is both medicinal material and the genuine food and medicament dual-purpose food materials of food that above-mentioned raw materials medicinal material, which is selected, safe to the human body harmless.
The preparation method of the above-mentioned food and medicament dual-purpose composition for having effects that reinforcing both QI and YIN, strengthening the body resistance to consolidate the constitution, including following operation
Step:
S1. raw material crushes: weighing longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, Radix Glycyrrhizae cleaning in parts by weight
After crushing, comminuting matter is obtained；
S2. it impregnates: by the comminuting matter in S1, water being added to be impregnated；
S3. wall-breaking abstraction: step S2 is impregnated into material by the continuous dynamic extraction of pressure difference aqueous fluid, obtains extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: the absolute extract liquid of step S4 is subjected to molecular sieve filtration, obtains target extract liquor；
S6. it is concentrated: the target extract liquor of step S5 being successively subjected to reverse osmosis membrane concentration and reduced pressure, obtains thick medicinal extract, it will be thick
It is dry after medicinal extract is crystallized, material is made to get gynaecology's postpartum Orally administered composition.
Optionally, crush in step S1 is specially by longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, sweet
Grass cleaning is crushed to 30 ~ 300 mesh.
Optionally, 10 ~ 30min of water immersion that 15 ~ 30 times of volumes are specially added is soaked in water in step S2.
Optionally, in step S3 the continuous dynamic extraction of pressure difference torrent low pressure be 3MPa ~ 5MPa, high pressure be 18MPa ~
20MPa, Extracting temperature are 25 ~ 65 DEG C, and extraction time is 20 ~ 60min.
Optionally, molecular sieve filtration is successively to be sieved through filter by many-level molecule in step S5, wherein filtering molecular sieves for the first time
Filtration MW having a size of 10000nm ~ 100000nm, the filtration MW of quadratic component sieve is having a size of 50nm ~ 800nm, end
The filtration MW of secondary molecular sieve is having a size of 10nm~100nm.
Optionally, it carries out reverse osmosis membrane in step S6 first to target extract liquor and is concentrated into Baume degrees to be 2 ~ 15, then exist
Vacuum degree -0.09MPa carries out being concentrated under reduced pressure into Baume degrees 20 ~ 35 under the conditions of 45 ~ 55 DEG C, obtains thick medicinal extract.
Above-mentioned reinforcing both QI and YIN, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution are whole during the preparation process to be existed using near infrared spectrum
Line analysis technology realizes the online timely, Visible human plan to product quality.
Above-mentioned composition when in use, with appropriate warm boiled water, exaggerates to postpartum overstrain, gas yin two caused by blood loss yin deficiency
The symptoms such as dizziness caused by void, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation can play rapid recovery and therapeutic effect.
Reinforcing both QI and YIN of the present invention, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution, using longan, fructus lycii as monarch drug in a prescription, two medicines are the same as use
The function that can reinforce blood nourishing and kidney tonifying declines for heart spleen deficiency, the diseases such as insomnia caused by insufficiency of vital energy and blood, amnesia, palpitation with fear, dizziness.Mountain
Medicine, rhizoma polygonati are ministerial drug, and two medicines share tonifying speen and tonifying kidney effect enhancing, with monarch drug in a prescription fructus lycii with using, to increase nourishing yin effect.Rose, mulberry
Shen, jujube, Radix Glycyrrhizae are adjuvant, and rose, mulberry fruit, jujube and upper all medicine compatibilities reinforce nourishing yin and supplementing blood, promoting qi circulation and removing obstruction in the collateral and blood
Analgesic, improves mood, fills blood, improves microcirculation disorder calmness, uncomfortable to palpitation caused by deficiency of both qi and yin, shortness of breath, pareordia
There is improvement result.Radix Glycyrrhizae replenishes qi to invigorate the spleen, and mitigates the property of all medicines, solves the poison of all medicines, with jujube mutual reinforcement between and 5, though the power of help is not
And ginseng, stilbene, but disadvantage that is of no help and loving heresy, there is the tune benefit effect mitigated；Delay flat property with originally sweet with ministerial drug Chinese yam, mends
For spleen benefit lung without disliking its high violent, nourishing Yin and promoting production of body fluid does not dislike its taste greasy again.Reinforcing both QI and YIN can be reached entirely, the effect of strengthening the body resistance to consolidate the constitution.With
Alleviate postpartum overstrain to exaggerate, dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation
Etc. symptoms.
Compared with prior art, the invention has the following advantages and beneficial effects:
1, the formula of innovative product of the present invention, with longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, eight taste of Radix Glycyrrhizae
The effective component of product is made in medicine, has reinforcing both QI and YIN, effect of strengthening the body resistance to consolidate the constitution.It exaggerates for postpartum overstrain, caused by blood loss yin deficiency
The symptoms such as dizziness caused by deficiency of both qi and yin, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation, can be the special physiological phase in women postpartum
The multifunctional compositions of a kind of more safety and fashion are provided；
2, the present invention select the continuous cleaning crushing of dynamic+present invention selection repeatedly differential pressure fluid broken wall+continuous gradient molecule sieving+
Low temperature is concentrated and dried the orientation abstraction technique combination such as crystallization+on-line near infrared spectroscopy analysis, by longan, fructus lycii, Chinese yam, Huang
Essence, rose, mulberries, jujube, Radix Glycyrrhizae are crushed using cleaning, with the continuous dynamically and directionally broken wall of pressure difference water flow and molecular sieve selections
Take, the harmful components such as removing heavy metals, agriculture are residual, change is residual, bacterium, impurity can be gone to greatest extent, and efficiently, completely by contained small point
Sub- effective component separating and extracting；And this extracting method is suitble to the manufacture of 4.0 wisdom of high-volume quantity-produced, and overall process is without adding
Heat, non-exhaust emission, industrial water can be recycled and be recycled, and waste residue full price utilizes, and comply fully with green manufacturing standard,
Wisdom manufacture operability and ecological environment cost performance with higher；
3, torrent extraction stages of the present invention, vacuum concentration stage and drying phase under vacuum, temperature control within 35-65 DEG C, entirely
Journey low temperature is more advantageous to compared with traditional water boiling and extraction technique and guarantees active principle activity；
4, present invention extraction material belongs to high loose crystalline solid, and molecular weight is small and uniformity is good, and dissolubility is good, cold and hot all molten, and
Any excipient is not added, anticaking agent, the auxiliary materials such as flavoring agent, preservative, the scope of application is wider safer；
5, the Chinese medicine in inventive formulation is food and medicament dual-purpose food materials, safe and non-toxic, can be used for a long time, and women special physiological is suitable for
The health care in postpartum phase.
6, product of the present invention ingredient is small-molecule substance, is easily directly absorbed by mucous membranes such as oral cavity and throat and oesophaguses,
The significant biopotency of comparison is shown, so as to comparatively fast play nutrient energy supplement and balanced action.
7, product of the present invention can be completely dissolved within 3 seconds, as clear as crystal, without any precipitating and impurity, be retained
There is the smell of former 80% or more plant material to plant fragrant, consumer is easier to receive.
Specific embodiment
The technical scheme of the invention is described in detail through specific implementation examples.
It is both medicinal material and the genuine food and medicament dual-purpose food materials of food that bulk pharmaceutical chemicals in following embodiments, which are selected, is pacified to human body
Completely without evil.
Embodiment 1
One kind having reinforcing both QI and YIN, the composition of effect of strengthening the body resistance to consolidate the constitution, and effective component is prepared by the raw material of following parts by weight
It forms: 15 parts of longan, 15 parts of fructus lycii, 15 parts of Chinese yam, 13 parts of rhizoma polygonati, 7 parts of rose, 15 parts of mulberries, 13 parts of jujube, Radix Glycyrrhizae 7
Part.
Preparation method, including following operating procedure:
S1. raw material crushes: weighing longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, Radix Glycyrrhizae cleaning in parts by weight
60 ~ 150 mesh are crushed to, comminuting matter is obtained；
S2. impregnate: by the comminuting matter in S1, the water that 20 times of amounts are added impregnates 30 minutes；
S3. wall-breaking abstraction: material is 4MPa in low pressure after step S2 is impregnated, and high pressure 20MPa, Extracting temperature is 35 ~ 50 DEG C
Under the conditions of the continuous Dynamic Extraction of pressure difference aqueous fluid 45 minutes, obtain extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the filtration MW of the absolute extract liquid of step S4 filtering molecular sieve for the first time having a size of 10000nm
~ 100000nm, the filtration MW of quadratic component sieve having a size of 50nm ~ 800nm, take measurements by the filtering molecular of last molecular sieve
For 10nm~100nm, target extract liquor is obtained；
S6. it is concentrated: the target extract liquor of step S5 successively being carried out reverse osmosis membrane to be concentrated into Baume degrees being 2, obtains primary extract；So
It is afterwards -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees 25 under the conditions of 50 DEG C, obtain thick medicinal extract；It will be thick
It is dry after medicinal extract is crystallized, material is made to get the composition.
Embodiment 2
One kind having reinforcing both QI and YIN, and the food and medicament dual-purpose composition of effect of strengthening the body resistance to consolidate the constitution, effective component is by following parts by weight
Raw material is prepared: 20 parts of longan, 5 parts of fructus lycii, 30 parts of Chinese yam, 13 parts of rhizoma polygonati, 7 parts of rose, 10 parts of mulberries, jujube 20
Part, 7 parts of Radix Glycyrrhizae.
It is above-mentioned that there is reinforcing both QI and YIN, the preparation method of the food and medicament dual-purpose composition of effect of strengthening the body resistance to consolidate the constitution, with embodiment 1.
Embodiment 3
One kind having reinforcing both QI and YIN, and the food and medicament dual-purpose composition of effect of strengthening the body resistance to consolidate the constitution, effective component is by following parts by weight
Raw material is prepared: 5 parts of longan, 30 parts of fructus lycii, 20 parts of Chinese yam, 20 parts of rhizoma polygonati, 5 parts of rose, 5 parts of mulberries, 25 parts of jujube,
5 parts of Radix Glycyrrhizae.
It is above-mentioned that there is reinforcing both QI and YIN, the preparation method of the food and medicament dual-purpose composition of effect of strengthening the body resistance to consolidate the constitution, with embodiment 1.
Embodiment 4
One kind having reinforcing both QI and YIN, and the food and medicament dual-purpose composition of effect of strengthening the body resistance to consolidate the constitution, effective component is by following parts by weight
Raw material is prepared: 10 parts of longan, 10 parts of fructus lycii, 10 parts of Chinese yam, 25 parts of rhizoma polygonati, 10 parts of rose, 20 parts of mulberries, jujube 10
Part, 10 parts of Radix Glycyrrhizae.
It is above-mentioned that there is reinforcing both QI and YIN, the preparation method of the food and medicament dual-purpose composition of effect of strengthening the body resistance to consolidate the constitution, including following operation
Step:
S1. raw material crushes: weighing longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, Radix Glycyrrhizae cleaning in parts by weight
30 ~ 150 mesh are crushed to, comminuting matter is obtained；
S2. impregnate: by the comminuting matter in S1, the water that 30 times of amounts are added impregnates 10 minutes；
S3. wall-breaking abstraction: material is 5MPa in low pressure after step S2 is impregnated, and high pressure 19MPa, Extracting temperature is 25 ~ 40 DEG C
Under the conditions of the continuous Dynamic Extraction of pressure difference aqueous fluid 60 minutes, obtain extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the filtration MW of the absolute extract liquid of step S4 filtering molecular sieve for the first time having a size of 10000nm
~ 100000nm, the filtration MW of quadratic component sieve having a size of 50nm ~ 800nm, take measurements by the filtering molecular of last molecular sieve
For 10nm~100nm, target extract liquor is obtained；
S6. it is concentrated: the target extract liquor of step S5 successively being carried out reverse osmosis membrane to be concentrated into Baume degrees being 15, obtains primary extract；
Then it is -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees 35 under the conditions of 55 DEG C, obtain thick medicinal extract；It will
It is dry after thick medicinal extract is crystallized, material is made to get the composition.
Embodiment 5
One kind having reinforcing both QI and YIN, and the food and medicament dual-purpose composition of effect of strengthening the body resistance to consolidate the constitution, effective component is by following parts by weight
Raw material is prepared: 30 parts of longan, 20 parts of fructus lycii, 5 parts of Chinese yam, 5 parts of rhizoma polygonati, 20 parts of rose, 30 parts of mulberries, 5 parts of jujube,
15 parts of Radix Glycyrrhizae.
It is above-mentioned that there is reinforcing both QI and YIN, the preparation method of the food and medicament dual-purpose composition of effect of strengthening the body resistance to consolidate the constitution, including following operation
Step:
S1. raw material crushes: weighing longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, Radix Glycyrrhizae cleaning in parts by weight
100 ~ 300 mesh are crushed to, comminuting matter is obtained；
S2. impregnate: by the comminuting matter in S1, the water that 15 times of amounts are added impregnates 20 minutes；
S3. wall-breaking abstraction: material is 3MPa in low pressure after step S2 is impregnated, and high pressure 18MPa, Extracting temperature is 45 ~ 65 DEG C
Under the conditions of the continuous Dynamic Extraction of pressure difference aqueous fluid 20 minutes, obtain extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the filtration MW of the absolute extract liquid of step S4 filtering molecular sieve for the first time having a size of 10000nm
~ 100000nm, the filtration MW of quadratic component sieve having a size of 50nm ~ 800nm, take measurements by the filtering molecular of last molecular sieve
For 10nm~100nm, target extract liquor is obtained；
S6. it is concentrated: the target extract liquor of step S5 successively being carried out reverse osmosis membrane to be concentrated into Baume degrees being 10, obtains primary extract；
Then it is -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees 20 under the conditions of 45 DEG C, obtain thick medicinal extract；It will
It is dry after thick medicinal extract is crystallized, material is made to get the composition.
Comparative example 1
This comparative example, effective component are prepared by following raw material in parts by weight: 50 parts of longan, 50 parts of fructus lycii.Specifically
The preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keep bulk pharmaceutical chemicals total weight number it is constant, and monarch drug in a prescription use
In the case where measuring constant rate, ministerial drug and adjuvant are saved.Drug effect verification result shows that the comparative example is to production compared to embodiment 1
Overstrain is exaggerated afterwards, the symptoms such as dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation
Without apparent treatment and alleviate effect.
Comparative example 2
This comparative example, effective component are prepared by following raw material in parts by weight: 26 parts of longan, 26 parts of fructus lycii, Chinese yam
26 parts, 22 parts of rhizoma polygonati.It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keep bulk pharmaceutical chemicals total weight number it is constant, monarch drug in a prescription, minister
Survival dose constant rate, saves adjuvant.Drug effect verification result shows that, compared to embodiment 1, which exaggerates to postpartum overstrain,
The treatment and alleviation of the symptoms such as dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation
Effect is decreased obviously.
Comparative example 3
This comparative example, effective component are prepared by following raw material in parts by weight: 30 parts of longan, 15 parts of Chinese yam, rhizoma polygonati 13
Part, 7 parts of rose, 15 parts of mulberries, 13 parts of jujube, 7 parts of Radix Glycyrrhizae.It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keep bulk pharmaceutical chemicals total weight number it is constant, monarch drug in a prescription longan
Ratio increases, and saves fructus lycii, and adjuvant is constant, and drug effect verification result shows that the comparative example is to postpartum labor compared to embodiment 1
Tired to exaggerate, the symptoms such as dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation are controlled
It treats and alleviates effect and be decreased obviously.
Comparative example 4
This comparative example, effective component are prepared by following raw material in parts by weight: 15 parts of longan, 15 parts of fructus lycii, Poria cocos
15 parts, 13 parts of rhizoma polygonati, 7 parts of rose, 15 parts of mulberries, 13 parts of jujube, 7 parts of Radix Glycyrrhizae；It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keep bulk pharmaceutical chemicals total weight number it is constant, use and mountain
The similar Poria cocos of medicine action and efficacy replaces Chinese yam, and drug effect verification result shows that the comparative example is to postpartum overstrain compared to embodiment 1
It exaggerates, the symptoms such as dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, palpitaition, lazy speech, burnout are without apparent treatment and alleviate function
Effect, treatment and alleviation effect to symptoms such as dry caused by postpartum deficiency of both qi and yin, night sweat dysphoria with smothery sensation are decreased obviously.
Comparative example 5
This comparative example, effective component are prepared by following raw material in parts by weight: 15 parts of longan, 15 parts of raspberry, Chinese yam
15 parts, 13 parts of rhizoma polygonati, 7 parts of rose, 15 parts of mulberries, 13 parts of jujube, 7 parts of Radix Glycyrrhizae；It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, Chinese holly is replaced using the raspberry similar with fructus lycii action and efficacy
Qi, drug effect verification result show that, compared to embodiment 1, which exaggerates to postpartum overstrain, and deficiency of both qi and yin caused by blood loss yin deficiency draws
The treatment of the symptoms such as the dizziness, palpitaition, lazy speech, the burnout that rise and alleviation effect are decreased obviously, to mouth caused by postpartum deficiency of both qi and yin
The apparent treatment of the nothing of the symptoms such as dry, night sweat dysphoria with smothery sensation and alleviation effect.
Comparative example 6
This comparative example, effective component are prepared by following raw material in parts by weight: 15 parts of longan, 15 parts of fructus lycii, Chinese yam
15 parts, 13 parts of lily, 7 parts of rose, 15 parts of mulberries, 13 parts of jujube, 7 parts of Radix Glycyrrhizae.
This comparative example difference from example 1 is that, rhizoma polygonati is replaced using lily similar to rhizoma polygonati effect, drug effect tests
Card the result shows that, compare embodiment 1, which exaggerates to postpartum overstrain, dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency,
The treatment of the symptoms such as palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation and alleviation effect are decreased obviously.
Comparative example 7
This comparative example, effective component are prepared by following raw material in parts by weight: 32 parts of longan, 4 parts of fructus lycii, Chinese yam 15
Part, 13 parts of rhizoma polygonati, 7 parts of rose, 15 parts of mulberries, 10 parts of jujube, 4 parts of Radix Glycyrrhizae.It is specific that the preparation method is the same as that of Example 1.
Compared with Example 1 compared with: the preparation method of comparative example does not change, but the proportion being formulated changes, wherein monarch drug in a prescription longan
Ratio increases, and fructus lycii ratio reduces, and full side's reinforcing both QI and YIN strengthens the body resistance to consolidate the constitution, exaggerated with alleviating postpartum overstrain, caused by blood loss yin deficiency
The effect of symptoms such as dizziness caused by deficiency of both qi and yin, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation be just not so good as former ratio it is comprehensive and
It works well, the proportion of this formula is whole not in the invention patent ratio range, influences to be formulated effect, reduces therapeutic effect.
Comparative example 8
This comparative example, effective component are prepared by following raw material in parts by weight: 15 parts of longan, 15 parts of fructus lycii, Chinese yam
32 parts, 4 parts of rhizoma polygonati, 4 parts of rose, 10 parts of mulberries, 13 parts of jujube, 7 parts of Radix Glycyrrhizae.It is specific that the preparation method is the same as that of Example 1.
Compared with Example 1 compared with: the preparation method of comparative example does not change, but the proportion being formulated changes, wherein ministerial drug Chinese yam
Ratio increases, and the ratio of rhizoma polygonati reduces, and full side's reinforcing both QI and YIN strengthens the body resistance to consolidate the constitution, exaggerated with alleviating postpartum overstrain, caused by blood loss yin deficiency
The effect of symptoms such as dizziness caused by deficiency of both qi and yin, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation be just not so good as former ratio it is comprehensive and
It works well, the proportion of this formula is whole not in the invention patent ratio range, influences to be formulated effect, reduces therapeutic effect.
Comparative example 9
This comparative example, effective component are prepared by following raw material in parts by weight: 10 parts of longan, 10 parts of fructus lycii, Chinese yam 4
Part, 26 parts of rhizoma polygonati, 5 parts of rose, 31 parts of mulberries, 4 parts of jujube, 10 parts of Radix Glycyrrhizae.It is specific that the preparation method is the same as that of Example 1.
Compared with embodiment: the preparation method of comparative example does not change, but the proportion being formulated changes, wherein ministerial drug mulberries ratio
Example increases, and rhizoma polygonati ratio increases；Adjuvant mulberries ratio increases.Full side's reinforcing both QI and YIN, strengthens the body resistance to consolidate the constitution, to alleviate postpartum overstrain mistake
Very, the effect of the symptoms such as dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, palpitaition, lazy speech, burnout, dry, night sweat dysphoria with smothery sensation just
It comprehensively and works well not as good as former ratio, proportion of this formula is whole not in the invention patent ratio range, influences to be formulated function
Effect reduces therapeutic effect.
By the drug effect verification result of above-mentioned comparative example and embodiment 1 it is found that ministerial drug or adjuvant when formula omit, formula
The type of middle replacement bulk pharmaceutical chemicals is the bulk pharmaceutical chemicals with same drug effect, changes the bulk pharmaceutical chemicals usage ratio of formula, can be made entire
The effect of formula, changes, so that effect declines, or cannot play more comprehensively comprehensive action and efficacy, or even will appear
Gas effect can only be augmented, the effects of obviously enriching blood enriching yin cannot be played, it can be seen that the selection longan, Chinese holly of the invention
Matrimony vine, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, Radix Glycyrrhizae compound manufactured effective component, utilize the spy of each bulk pharmaceutical chemicals itself
Different property makes to can be good at playing collaboration compatibility effect, raising and abundant curative effect of medication between each other.
Test example
Clinical effectiveness verification test:
Clinical case is chosen: choosing the speech of shortness of breath lazyness caused by clinical diagnosis postpartum, deficiency of both qi and yin postpartum, dizzy heart-throb person exists at the age
Patient 120 of 25 ~ 40 years old, are randomly divided into 10 groups；Choose dry throat, sweat dysphoria with smothery sensation person age at night caused by postpartum deficiency of both qi and yin
In patient 120 of 25 ~ 40 years old, it is randomly divided into 10 groups；
Every group of patient is corresponding respectively using the product of embodiment 1, comparative example 1 ~ 9；
Application method: each 2g, 150ml or so warm boiled water, 3 times a day；
Use the course for the treatment of: 7 days
Curative effect determinate standard:
Effective: symptom disappears after taking 7 days or integral reduces >=70%；
Effective: symptom improves after taking 7 days, integrates less >=30%, < 70%；
Invalid: symptom reduces < 30% without alleviation or integral after after taking 7 days.
The effective percentage and inefficiency of every group of patient are counted, wherein efficient is (effective number+effective number)/total case
Number；Inefficiency is invalid number/total case number, as a result as shown in table 1 below:
Table 1
Embodiment 3, clinical effectiveness and the embodiment 1 of 4 product of embodiment are basic is equal, the comprehensive effect of embodiment 2 and embodiment 5
Fruit is not so good as embodiment 1, but comprehensive function effect is better than comparative example 1 ~ 9.
Each product is observed and recorded to the effect of the speech of shortness of breath lazyness caused by postpartum deficiency of both qi and yin, dizzy palpitaition, the results showed that
3 > comparative example of embodiment 1 > comparative example, 2 > comparative example, 5 > comparative example, 7 > comparative example, 9 > comparative example, 6 > comparative example, 8 > comparison
1 > comparative example 4 of example.
Each product is observed and recorded to the effect of dry throat caused by postpartum deficiency of both qi and yin, night sweat dysphoria with smothery sensation, the results showed that
7 > comparative example of embodiment 1 > comparative example, 2 > comparative example, 4 > comparative example, 3 > comparative example, 6 > comparative example, 8 > comparative example, 9 > comparison
5 > comparative example 1 of example.
By the result of the clinical effectiveness verification test of above-mentioned test example it is found that 1 product of embodiment has reinforcing both QI and YIN, righting
Consolidate effect.Exaggerate for postpartum overstrain, dizziness caused by deficiency of both qi and yin caused by blood loss yin deficiency, palpitaition, lazy speech, burnout, dry,
The symptoms such as night sweat dysphoria with smothery sensation generate significant treatment and relaxation effect.Change the usage ratio of inventive formulation bulk pharmaceutical chemicals, change is matched
The monarch compatibility of side, or even bulk pharmaceutical chemicals are being replaced with into other bulk pharmaceutical chemicals with same drug effect, it can all influence product
Entire effect.The present invention by innovation the suitable bulk pharmaceutical chemicals of selection, using the specific pharmacological property of bulk pharmaceutical chemicals, make its mutually it
Between cooperate with compatibility, while simplifying formula, so that the product of preparation has multi-efficiency, can be used as women postpartum and special life
The safe Oral compositions Tetramune in reason period.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (9)
1. a kind of reinforcing both QI and YIN, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution, which is characterized in that its effective component is by following parts by weight
Several raw materials are prepared: 5~30 parts of longan, 5~30 parts of fructus lycii, 5~30 parts of Chinese yam, 5~25 parts of rhizoma polygonati, rose 5~
20 parts, 5~30 parts of mulberries, 5~25 parts of jujube, 5~15 parts of Radix Glycyrrhizae.
2. reinforcing both QI and YIN as described in claim 1, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution, which is characterized in that its effectively at
Divide and be prepared by following raw material in parts by weight: 10~20 parts of longan, 10~20 parts of fructus lycii, 10~20 parts of Chinese yam, rhizoma polygonati
10~20 parts, 5~10 parts of rose, 10~20 parts of mulberries, 10~20 parts of jujube, 5~10 parts of Radix Glycyrrhizae.
3. reinforcing both QI and YIN as described in claim 1, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution, which is characterized in that its effectively at
Divide and be prepared by following raw material in parts by weight: 15 parts of longan, 15 parts of fructus lycii, 15 parts of Chinese yam, 13 parts of rhizoma polygonati, rose 7
Part, 15 parts of mulberries, 13 parts of jujube, 7 parts of Radix Glycyrrhizae.
4. a kind of preparation side of such as described in any item reinforcing both QI and YINs of claim 1 ~ 3, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution
Method, which is characterized in that including following operating procedure:
S1. raw material crushes: weighing longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, Radix Glycyrrhizae cleaning in parts by weight
It crushes, obtains comminuting matter；
S2. it impregnates: by the comminuting matter in S1, water being added to be impregnated；
S3. wall-breaking abstraction: step S2 is impregnated into material by the continuous dynamic extraction of pressure difference aqueous fluid, obtains extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: the absolute extract liquid of step S4 is subjected to molecular sieve filtration, obtains target extract liquor；
S6. it is concentrated: the target extract liquor of step S5 being successively subjected to reverse osmosis membrane concentration and vacuum-concentrcted, obtains thick medicinal extract,
It is dry after thick medicinal extract is crystallized, material is made to get the composition.
5. the preparation method of reinforcing both QI and YIN as claimed in claim 4, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution, feature exist
In the low pressure of the continuous dynamic extraction of pressure difference torrent is 3MPa ~ 5MPa in step S3, and high pressure is 18MPa ~ 20MPa, and Extracting temperature is
25 ~ 65 DEG C, extraction time is 20 ~ 60min.
6. the preparation method of reinforcing both QI and YIN as claimed in claim 4, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution, feature exist
In molecular sieve filtration is successively to be sieved through filter by many-level molecule in step S5, wherein the filtration MW of filtering molecular sieve for the first time
Having a size of 10000nm ~ 100000nm, the filtration MW of quadratic component sieve is having a size of 50nm ~ 800nm, the mistake of last molecular sieve
Filter molecular weight sizes are 10nm~100nm.
7. the preparation method of reinforcing both QI and YIN as claimed in claim 4, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution, feature exist
In, target extract liquor is carried out first in step S6 reverse osmosis membrane be concentrated into Baume degrees be 2 ~ 15, then in vacuum degree-
0.09MPa carries out being concentrated under reduced pressure into Baume degrees 20 ~ 35 under the conditions of 45 ~ 55 DEG C, obtains thick medicinal extract.
8. the preparation method of reinforcing both QI and YIN as claimed in claim 4, the food and medicament dual-purpose composition strengthened the body resistance to consolidate the constitution, feature exist
In the water soaked in water in step S2 as addition 15 ~ 30 times of volumes of material impregnates 10 ~ 30min.
9. the preparation method of food and medicament dual-purpose composition for having effects that reinforcing both QI and YIN as claimed in claim 4, strengthening the body resistance to consolidate the constitution,
It is characterized in that, crushing in step S1 is by powder after longan, fructus lycii, Chinese yam, rhizoma polygonati, rose, mulberries, jujube, Radix Glycyrrhizae cleaning
It is broken to 30 ~ 300 mesh.
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Application publication date: 20190301 |