CN108143833A - A kind of preparation method of licorice piece - Google Patents

A kind of preparation method of licorice piece Download PDF

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Publication number
CN108143833A
CN108143833A CN201810024173.5A CN201810024173A CN108143833A CN 108143833 A CN108143833 A CN 108143833A CN 201810024173 A CN201810024173 A CN 201810024173A CN 108143833 A CN108143833 A CN 108143833A
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Prior art keywords
tabletting
preparation
raw material
radix glycyrrhizae
licorice piece
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王海
朱攀力
卜学彦
王纬
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Sichuan Zhengtang Pharmaceutical Co Ltd
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Sichuan Zhengtang Pharmaceutical Co Ltd
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Priority to CN201810024173.5A priority Critical patent/CN108143833A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of preparation methods of licorice piece, specifically include following steps:Step S1:Raw material selects and processing;Choose the raw material Chinese medicine of following components by weight percent:15 parts of 30 70 parts of Radix Glycyrrhizae, 15 30 parts of cassia seed, 8 15 parts of the fruit of Chinese wolfberry and chrysanthemum;Step S2:Removal of impurities, cleaning and drying;Step S3:Segment is handled;The rhizome portion of Radix Glycyrrhizae is done into segment processing;Step S4:Ground into end;Step S5:Aerosol softens;It specifically refers to:By the powder obtained by step S4, using blender, uniformly mixing is put into the softening of sealed compartment aerosol;Step S6:It is tabletted, tabletting is made;Mixed-powder after step S5 aerosols are softened is put into tabletted in compacting tool set;The present invention physically breaks crude drug cell wall using pure, and absorptivity is higher than common licorice piece, does not add any chemical composition;The present invention has effects that clearing heat and relieving fidgetness, driving away summer heat of promoting the production of body fluid, annealing;Made tabletting is easy to carry.

Description

A kind of preparation method of licorice piece
Technical field
The present invention relates to prepared slices of Chinese crude drugs technical fields, are a kind of preparation methods of licorice piece specifically.
Background technology
Radix Glycyrrhizae,(Scientific name:GlycyrrhizauralensisFisch)Alias:State is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet tea root Son.Pulse family, Glycyrrhiza perennial herb, root is sturdy with root-like stock, is a kind of preparation method help Chinese herbal medicine of licorice piece.It is right A kind of preparation method medicine of human body licorice piece well, medicinal part is root and rhizome, and Medicinal Materials Characters root is cylinder, long 25 ~100 centimetres, 0.6~3.5 centimetre of diameter.Crust is elastic to differ, surface rufous or taupe brown.Rhizome is cylinder, surface There is bud scar, have marrow in the middle part of section.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..Happiness is dark moist, and the long temperature of sunshine is low Dry climate.Radix Glycyrrhizae is grown in arid, semiarid desert steppe, desert edge and loess hill area more.Root and root shape Stem hyoscine;Radix Glycyrrhizae nature and flavor are sweet in flavor, mild-natured.The Radix Glycyrrhizae channel tropism thoughts of returning home, lung, spleen, stomach.Radix Glycyrrhizae effect is invigorated the spleen and benefited qi, clearing heat and detoxicating, Expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
Now with people's living standards continue to improve, more and more people also more aggravate the health of itself Depending on general Western medicine is palliative drug for most Chinese people, to body, so still big portion now Component selections Chinese medicine effectively improves the body of oneself.
Licorice tablet is brown piece or brown color chips;There is special smell, it is sweet;The easy moisture absorption.So drying should be kept, licorice tablet is Kobadrin drug, effect is rather extensive, in traditional Chinese herbal decoction and Chinese patent drug compatibility, commonly uses its tonifying Qi benefit spleen and middle emergency, tune The effect of with all medicines;Extract of licorice root and preparation after refinement and processing are that a kind of preparation method of licorice piece has well Cough-relieving, eliminating the phlegm, antiasthmatic effect drug.The traditional Chinese medical science think Radix Glycyrrhizae have invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, tune The effect of with all medicines is " state is old " in Chinese medicine, is one of most common Chinese medicinal material, and most of Traditional Chinese medicinal prescription has all been arranged in pairs or groups sweet Grass.
Be fabricated to medicine materical crude slice with Radix Glycyrrhizae, be not only convenient for carrying, but also can drink at any time, traditional Radix Glycyrrhizae be made the method for medicine materical crude slice compared with To be coarse, step is also cumbersome, is not available for the production and processing of scale, and present mechanical manufacturing technology, often can not be accurate Judgement performance when drug is processed, can cause Radix Glycyrrhizae to be caused in licorice piece preparation process when medicine materical crude slice processed The loss of nutritional ingredient influences to use drug effect.
Invention content
The purpose of the present invention is to provide a kind of preparation methods of licorice piece, physically break crude drug cell using pure Wall, absorptivity are higher than common licorice piece, do not add any chemical composition;With clearing heat and relieving fidgetness, driving away summer heat of promoting the production of body fluid, the work(annealed Effect;
Prepared licorice piece is easy to carry.
The present invention is achieved through the following technical solutions:A kind of preparation method of licorice piece, specifically includes following steps:
Step S1:Raw material selects and processing;Choose the raw material Chinese medicine of following components by weight percent:30-70 parts of Radix Glycyrrhizae, cassia seed 15-30 1-5 parts of part, 8-15 parts of the fruit of Chinese wolfberry and chrysanthemum;
Step S2:Removal of impurities, cleaning and drying;
Step S3:Segment is handled;The rhizome portion of Radix Glycyrrhizae is done into segment processing;
Step S4:Ground into end;
Step S5:Aerosol softens;It specifically refers to:
By the powder obtained by step S4, using blender, uniformly mixing is put into the softening of sealed compartment aerosol;
Step S6:It is tabletted, tabletting is made;Mixed-powder after step S5 aerosols are softened, which is put into compacting tool set, to be pressed into Piece;
Step S7:Tabletting is dried;Tabletting is put into 80 DEG C of drying in far infrared constant temperature drying box.
Further, it in order to preferably realize the present invention, also needs to carry out at sterilization tabletting before the tabletting drying Reason.
Further, in order to preferably realize the present invention, the sterilization processing specifically refers to:Tabletting is placed in 70-80 DEG C Hot environment in sterilize 30min.
Further, in order to preferably realize the present invention, the step S2 specifically includes following steps:
Step S21:The raw material Chinese medicine chosen in step S1 is cleaned and cleaning treatment respectively;
Step S22:Raw material Chinese medicine after being cleaned in step S21 is dried;The drying specifically refers to put in raw material Chinese medicine It is dried in in far infrared constant temperature drying box 60 DEG C.
Further, in order to preferably realize the present invention, the cleaning treatment is specifically referred to Radix Glycyrrhizae, cassia seed and Chinese holly Matrimony vine is put into medicine-washing machine, is cleaned using flowing water;The medicine-washing machine is cartridge type medicine-washing machine, and the rotating speed of the cylinder is 5-8r/ Min, scavenging period 20-23min;
Further, in order to preferably realize the present invention, the step S4 is specifically referred to:By the Radix Glycyrrhizae in step S3 and step S2 Cassia seed, the fruit of Chinese wolfberry and chrysanthemum after middle cleaning are mixed and added into oscillatory type ultramicro grinding grinding kneading machine and crush;Sieve mesh It is required that for more than 220 sieve meshes, superfines is made.
Further, in order to preferably realize the present invention, the step S6 is specifically referred to:After step S5 aerosols are softened Mixed-powder is put into tabletted in compacting tool set, obtained tabletting.
Further, in order to preferably realize the present invention, the thickness of the tabletting is 3-5mm, described to use compacting tool set It carries out tabletting making to specifically refer under the pressure of 500-500kg/m2, mixed-powder is suppressed 3-5 minutes.
Further, in order to preferably realize the present invention, step S8 is further included:Tabletting sealed packaging in step S7 is protected It deposits.
The elderly that pregnancy and women breast-feeding their children, hypertrophy of the prostate urination are had any problem long-term is addicted to drink and steady drinker, on ordinary days The very unstable person of mood should not use the licorice piece prepared.
Radix Glycyrrhizae:
Meridian distribution of property and flavor:It is mild-natured, it is sweet in flavor.Thoughts of returning home warp, stomach, the spleen channel, lung channel.
Effect and effect:Invigorate the spleen and benefit qi, cough-relieving apophlegmatic, emergency analgesic therapy, mediation property of medicine.Belong to the tonifying Qi classified under qi-restoratives medicine Medicine.
Radix Glycyrrhizae has cortex hormone of aadrenaline effect, and anti-inflammatory, antiulcer, antianaphylaxis, anticancer, antibacterial is antiviral, promotes Pancreatic secretion has in vitro intestines inhibition, adjusts immune function, kobadrin, anti-mutation, removing toxic substances is anti-oxidant, protects ear vestibular work( Can, diuresis, liver protection prevents artery sclerosis, anti-cerebral ischemia, the effects that preventing diabetic complication.
Cassia seed:
Meridian distribution of property and flavor:Cold nature, it is bitter, sweet.Return liver warp, kidney channel, large intestine channel.
Effect and effect:Heat-clearing improving eyesight relaxes bowel.Belong to the deficient heat clearing drug classified under antipyretic.
Pharmacology:There is antibacterial, prevention of arterial atherosis, anti-platelet aggregation;Inhibit cellular immune function, it is right Humoral immune function can enhance macrophage and swallow and bite function without influence;Liver protection;Under rushing down;Promote gastric secretion;Inhibit 15- hydroxyls The effect of base prostaglandin dehydrogenase.Its infusion has decompression, diuresis, and has laxative, shrinks uterus effect;Its alcohol leaches Liquid has inhibiting effect to the bacillus such as staphylococcus and diphtheria, huge gemma, typhoid fever, paratyphoid, paratyphoid B, large intestine;Its Flooding agent has inhibiting effect, and play the role of reducing blood lipid to a variety of pathogenic dermatophytes.
The fruit of Chinese wolfberry:
Meridian distribution of property and flavor:It is mild-natured, it is sweet in flavor.Return liver warp, kidney channel.
Effect and effect:Nourishing liver and kidney, benefiting shrewd head.Belong to the yin tonics of qi-restoratives medicine subordinate classification.
Pharmacology:Enhance immune function, anti-aging, antitumor, reducing blood lipid, liver protection, promote hematopoiesis function, anti-heredity damage Wound, hypoglycemic, blood pressure lowering inhibit heart and excited enteron aisle etc. to intend choline effect.
Chrysanthemum:
Meridian distribution of property and flavor:Cold nature is sweet in flavor, bitter.Distributed in lung channel, Liver Channel.
Effect and effect:Relieve heat heat-clearing, flat liver improving eyesight.Belong to the cold-pungent and diaphoretic drugs of diaphoretic medicine subordinate classification.
Pharmacology:There is antibacterial, expansion coronary artery, increase coronary flow, improve myocardial oxygen consumption.
Compared with prior art, the present invention haing the following advantages and advantageous effect:
(1)The present invention physically breaks crude drug cell wall using pure, and absorptivity is higher than common licorice piece, does not add any chemistry Ingredient;
(2)The present invention has effects that clearing heat and relieving fidgetness, driving away summer heat of promoting the production of body fluid, annealing;
(3)Licorice piece prepared by the present invention is easy to carry.
Specific embodiment
The present invention is described in further detail, but the implementation of the present invention is not limited to this with reference to embodiment.
Embodiment 1:
The present invention is achieved through the following technical solutions, and the present invention is achieved through the following technical solutions:A kind of preparation of licorice piece Method specifically includes following steps:
Step S1:Raw material selects and processing;Choose the raw material Chinese medicine of following components by weight percent:30-70 parts of Radix Glycyrrhizae, cassia seed 15-30 1-5 parts of part, 8-15 parts of the fruit of Chinese wolfberry and chrysanthemum;
Step S2:Removal of impurities, cleaning and drying;
Step S3:Segment is handled;The rhizome portion of Radix Glycyrrhizae is done into segment processing;
Step S4:Ground into end;
Step S5:Aerosol softens;It specifically refers to:
By the powder obtained by step S4, using blender, uniformly mixing is put into the softening of sealed compartment aerosol;
Step S6:It is tabletted, tabletting is made;Mixed-powder after step S5 aerosols are softened, which is put into compacting tool set, to be pressed into Piece;
Step S7:Tabletting is dried;Tabletting is put into far infrared constant temperature drying box, control temperature is dried at 80 DEG C.
Using far infrared constant temperature drying box can rapid draing, reach shorten the production cycle, it is energy saving, improve product matter Amount.
The other parts of the present embodiment are same as the previously described embodiments, and so it will not be repeated.
Embodiment 2:
The present embodiment advanced optimizes on the basis of above-described embodiment, also needs to carry out tabletting before the tabletting drying Sterilization processing.
The sterilization processing specifically refers to:Tabletting is placed in 70-80 DEG C of hot environment and sterilizes 30min.
The other parts of the present embodiment are same as the previously described embodiments, and so it will not be repeated.
Embodiment 3:
The present embodiment advanced optimizes on the basis of above-described embodiment, and the step S2 specifically includes following steps:
Step S21:The raw material Chinese medicine chosen in step S1 is cleaned and cleaning treatment respectively;
Step S22:Raw material Chinese medicine after being cleaned in step S21 is dried;The drying specifically refers to put in raw material Chinese medicine It is dried in in far infrared constant temperature drying box 60 DEG C.
The other parts of the present embodiment are same as the previously described embodiments, and so it will not be repeated.
Embodiment 4:
The present embodiment advanced optimizes on the basis of above-described embodiment, and the cleaning treatment is specifically referred to Radix Glycyrrhizae, Cassia Son and the fruit of Chinese wolfberry are put into medicine-washing machine, are cleaned using flowing water;The medicine-washing machine is cartridge type medicine-washing machine, and the rotating speed of the cylinder is 5-8r/min, scavenging period 20-23min.
The other parts of the present embodiment are same as the previously described embodiments, and so it will not be repeated.
Embodiment 5:
The present embodiment advanced optimizes on the basis of above-described embodiment, and the step S4 is specifically referred to:It will be in step S3 Radix Glycyrrhizae is mixed and added into oscillatory type ultramicro grinding grinding kneading machine with cassia seed, the fruit of Chinese wolfberry and the chrysanthemum after being cleaned in step S2 Middle crushing;Sieve mesh requirement is more than 220 sieve meshes, and superfines is made.
The other parts of the present embodiment are same as the previously described embodiments, and so it will not be repeated.
Embodiment 6:
The present embodiment advanced optimizes on the basis of above-described embodiment, and the step S6 is specifically referred to:By step S5 aerosols Mixed-powder after softening is put into tabletted in compacting tool set, obtained tabletting.
The thickness of the tabletting is 3-5mm, described to be specifically referred to using compacting tool set progress tabletting making in 500- Under the pressure of 500kg/m2, mixed-powder is suppressed 3-5 minutes.
Further include step S8:Tabletting sealed packaging in step S7 is preserved.
The other parts of the present embodiment are same as the previously described embodiments, and so it will not be repeated.
Embodiment 7:
The present embodiment is highly preferred embodiment of the present invention, and a kind of preparation method of licorice piece specifically includes following steps:
Step S1:Raw material selects and processing;Choose the raw material Chinese medicine of following components by weight percent:35 parts of Radix Glycyrrhizae, 15 parts of cassia seed, matrimony vine Sub 9 parts and 5 parts of chrysanthemum;
Step S2:Removal of impurities, cleaning and drying;The step S2 specifically includes following steps:
Step S21:The raw material Chinese medicine chosen in step S1 is cleaned and cleaning treatment respectively;
The cleaning treatment specifically refers to Radix Glycyrrhizae, cassia seed and the fruit of Chinese wolfberry being put into medicine-washing machine, is cleaned using flowing water;It is described Medicine-washing machine is cartridge type medicine-washing machine, and the rotating speed of the cylinder is 7r/min, scavenging period 20min;
Step S22:Raw material Chinese medicine after being cleaned in step S21 is dried;The drying specifically refers to put in raw material Chinese medicine In in far infrared constant temperature drying box, control temperature is dried at 60 DEG C.
Step S3:Segment is handled;The rhizome portion of Radix Glycyrrhizae is done into segment processing;
Step S4:Ground into end;It specifically refers to:
The Radix Glycyrrhizae in step S3 is mixed and added into oscillatory type with cassia seed, the fruit of Chinese wolfberry and the chrysanthemum after cleaning in step S2 to surpass It is crushed in micro mist breakdown mill kneading machine;Sieve mesh requirement is more than 250 sieve meshes, and superfines is made.
Step S5:Aerosol softens;It specifically refers to:
By the powder obtained by step S4, using blender, uniformly mixing is put into the softening of sealed compartment aerosol;
Step S6:It is tabletted, tabletting is made;Mixed-powder after step S5 aerosols are softened, which is put into compacting tool set, to be pressed into Piece;Tabletting is placed in 75 DEG C of hot environment and sterilizes 30min.Mixed-powder after step S5 aerosols are softened is put into pressing die It is tabletted in tool, tabletting is made.The thickness of the tabletting is 4mm, described to be specifically using compacting tool set progress tabletting making Refer under the pressure of 500-500kg/m2, mixed-powder is suppressed 5 minutes.
Step S7:Tabletting is dried;Tabletting is put into 80 DEG C of drying in far infrared constant temperature drying box.
Step S8:Tabletting sealed packaging in step S7 is preserved.
Toxicology test is carried out for the present invention:
Acute toxicity test:
Experimental observation because that can not measure LD50, therefore has carried out the measure of maximum dosage-feeding.Chinese medicine compound prescription prepared by embodiment 1 Mixture is dissolved in sterile saline, is configured to solution gavage mouse, the results show that being given birth to drug maximum administration concentration 9.65 Medicine/ml, for maximum administered volume 50ml/kg in being administered twice in 24 hours to intragastric administration on mice, mouse maximum dosage-feeding is 763.25g Crude drug/kg, animal do not occur adverse reaction and death, and each internal organs no abnormality seen is dissected and observed.
Long term toxicity test
SD rats 80 are applied in this experiment, and Chinese medicine compound prescription mixture prepared by embodiment 1 is dissolved in sterile saline, are configured Into solution gavage, if control group and 24g, 35g, 49g crude drug/kg dosage groups, continuous gavage is administered 12 weeks, observes in the present invention Influence of the drug composition to animal indices.Result of the test shows successive administration 12 weeks, and Chinese medicine composition of the invention is to big Weight, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index of mouse etc. have no significant effect;Blood biochemical 12 Item index determining is as a result, 12 weeks low dose group BiLi values of administration are higher than control group(P<0.05);Low dose group, middle dose group TP values Higher than control group(P<0.05), but within normal physiologic range, other indexs no significant difference compared with the control group.Restore Phase each administration group indices measured value equal no significant difference compared with the control group.Each internal organs gross examination of skeletal muscle no abnormality seen of each group.
The other parts of the present embodiment are same as the previously described embodiments, and so it will not be repeated.
The above is only presently preferred embodiments of the present invention, not does limitation in any form to the present invention, it is every according to According to the present invention technical spirit above example is made any simple modification, equivalent variations, each fall within the present invention protection Within the scope of.

Claims (9)

1. a kind of preparation method of licorice piece, it is characterised in that:Specifically include following steps:
Step S1:Raw material selects and processing;Choose the raw material Chinese medicine of following components by weight percent:30-70 parts of Radix Glycyrrhizae, cassia seed 15-30 1-5 parts of part, 8-15 parts of the fruit of Chinese wolfberry and chrysanthemum;
Step S2:Removal of impurities, cleaning and drying;
Step S3:Segment is handled;The rhizome portion of Radix Glycyrrhizae is done into segment processing;
Step S4:Ground into end;
Step S5:Aerosol softens;It specifically refers to:
By the powder obtained by step S4, using blender, uniformly mixing is put into the softening of sealed compartment aerosol;
Step S6:It is tabletted, tabletting is made;Mixed-powder after step S5 aerosols are softened, which is put into compacting tool set, to be pressed into Piece;
Step S7:Tabletting is dried;Tabletting is put into 80 DEG C of drying in far infrared constant temperature drying box.
2. a kind of preparation method of licorice piece according to claim 1, it is characterised in that:Before the tabletting drying also It needs to carry out sterilization processing to tabletting.
3. a kind of preparation method of licorice piece according to claim 1, it is characterised in that:The sterilization processing is specifically Refer to:Tabletting is placed in 75 DEG C of hot environment and sterilizes 30min.
4. a kind of preparation method of licorice piece according to claim 1, it is characterised in that:The step S2 is specifically included Following steps:
Step S21:The raw material Chinese medicine chosen in step S1 is cleaned and cleaning treatment respectively;
Step S22:Raw material Chinese medicine after being cleaned in step S21 is dried;The drying specifically refers to put in raw material Chinese medicine It is dried in in far infrared constant temperature drying box 60 DEG C.
5. a kind of preparation method of licorice piece according to claim 3, it is characterised in that:The cleaning treatment is specifically Radix Glycyrrhizae, cassia seed and the fruit of Chinese wolfberry are put into medicine-washing machine by finger, are cleaned using flowing water;The medicine-washing machine be cartridge type medicine-washing machine, institute The rotating speed for stating cylinder is 7r/min, scavenging period 20min.
6. a kind of preparation method of licorice piece according to claim 1, it is characterised in that:The step S4 is specifically Refer to:The Radix Glycyrrhizae in step S3 is mixed and added into oscillatory type with cassia seed, the fruit of Chinese wolfberry and the chrysanthemum after cleaning in step S2 to surpass It is crushed in micro mist breakdown mill kneading machine;Sieve mesh requirement is more than 220 sieve meshes, and superfines is made.
7. a kind of preparation method of licorice piece according to claim 1, it is characterised in that:The step S6 is specifically Refer to:Mixed-powder after step S5 aerosols are softened is put into tabletted in compacting tool set, obtained tabletting.
8. a kind of preparation method of licorice piece according to claim 7, it is characterised in that:The thickness of the tabletting is 3- 5mm, it is described to be specifically referred to using compacting tool set progress tabletting making in 500-500kg/m2Pressure under, to mixed-powder suppress 3-5 minutes.
9. according to a kind of preparation method of licorice piece of claim 1-8 any one of them, it is characterised in that:Further include step S8:Tabletting sealed packaging in step S7 is preserved.
CN201810024173.5A 2018-01-10 2018-01-10 A kind of preparation method of licorice piece Pending CN108143833A (en)

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CN112915115A (en) * 2021-01-11 2021-06-08 安徽世茂中药股份有限公司 Rhodiola rosea decoction pieces and processing method thereof
CN112933130A (en) * 2021-01-11 2021-06-11 安徽世茂中药股份有限公司 Processing method of rhodiola rosea soaking decoction pieces

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