CN109394594A - A kind of anti-acne essence and its preparation method and application - Google Patents
A kind of anti-acne essence and its preparation method and application Download PDFInfo
- Publication number
- CN109394594A CN109394594A CN201811421998.7A CN201811421998A CN109394594A CN 109394594 A CN109394594 A CN 109394594A CN 201811421998 A CN201811421998 A CN 201811421998A CN 109394594 A CN109394594 A CN 109394594A
- Authority
- CN
- China
- Prior art keywords
- acne essence
- glycerol
- acne
- fermentation
- phytosterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of anti-acne essences and its preparation method and application.The anti-acne essence, by weight percentage, it include: propylene glycol 1-10%, glycerol 2-10%, glycine betaine 1-10%, erythrite 1-10%, allantoin 0.1-2%, Scleroglucan 0.1-2%, tara gum 0.1-2%, Pi Aoning 0.007%, Fermentation in Pichia Pastoris lysis object filtrate 5-25%, phytosterol 1-10%, 1,2- hexylene glycol 0.1-2%, base hexyl glycerol 0.01-0.1%, decoyl hydroximic acid 0.01-0.1%, water surplus.The anti-acne essence has the characteristics that mild, non-stimulated, without side-effects using obvious effect, performance；The anti-acne essence, without acute skin irritation, has extremely extensive security value without antibiotic；The simple production process of the anti-acne essence has high economic value；Raw material used in the anti-acne essence includes Fermentation in Pichia Pastoris lysis object filtrate and phytosterol etc., makes full use of abundance and quality-high and inexpensive resource, generates bigger economic and social benefit.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to a kind of anti-acne essence and its preparation method and application.
Background technique
Small pox and whelk are the most common skin problems, this also annoyings countless young men, at the most beautiful age, because
It feels oneself inferior for small pox on the face, influence is got along with other people, and sebaceous glands is excessively flourishing, and sebum secretion is excessively prosperous.If pore
It is blocked either because other reasons cause oil extraction unsmooth, then sebaceous glands continues to secrete, sebum is just accumulated in pore
Come, protrusion becomes small pox, and hormone in vivo secretion is unbalance, makes the long acne of skin.This reason is relatively common when hebetic.
Hormone secretion is unbalance also to cause indirectly sebum secretion excessively vigorous, to be further exacerbated by the situation of small pox, treat small pox
Cosmetics are increasing.But product for resolving poxes currently on the market is various, but generally existing following defect: (1) easily causing skin
Skin allergy is big to skin irritation；(2) the chemical bacteriostatic agent (such as addition salicylic acid, benzoyl peroxide bacteriostatic agent) being added
Destroy the normal flora of skin；(3) contain some hormonal substances and heavy metal substance.
Summary of the invention
It is an object of that present invention to provide a kind of anti-acne essences and its preparation method and application, are asked with solving above-mentioned technology
Topic.
In order to solve the above-mentioned technical problem, the technical solution of the present invention is as follows:
In a first aspect, a kind of anti-acne essence provided by the invention, by weight percentage, comprising: propylene glycol 1-10%,
Glycerol 2-10%, glycine betaine 1-10%, erythrite 1-10%, allantoin 0.1-2%, Scleroglucan 0.1-2%, tara gum
0.1-2%, Pi Aoning 0.001~0.01%, Fermentation in Pichia Pastoris lysis object filtrate 5-25%, phytosterol 1-
10%, 1,2- hexylene glycol 0.1-2%, base hexyl glycerol 0.01-0.1%, decoyl hydroximic acid 0.01-0.1%, water surplus.
Preferably, the anti-acne essence, by weight percentage, comprising: propylene glycol 2-5%, glycerol 3-5%, beet
Alkali 2-7%, erythrite 2-7%, allantoin 0.1-0.5%, Scleroglucan 0.1-0.6%, tara gum 0.1-0.5%, skin are proud
Peaceful 0.001~0.01%, Fermentation in Pichia Pastoris lysis object filtrate 10-20%, phytosterol 2-5%, 1,2- oneself two
Alcohol 0.1-0.5%, base hexyl glycerol 0.01-0.05%, decoyl hydroximic acid 0.01-0.03%, water surplus.
Preferably, the anti-acne essence, by weight percentage, comprising: propylene glycol 2%, glycerol 4%, glycine betaine
5%, erythrite 4%, allantoin 0.2%, Scleroglucan 0.2%, tara gum 0.1%, Pi Aoning 0.007%, Pasteur are finished
It is red yeast fermentation lysis object filtrate 10%, phytosterol 3%, 1,2- hexylene glycol 0.3%, Sensiva SC50 0.04%, pungent
Acyl hydroximic acid 0.02%, water surplus.
Preferably, the anti-acne essence, by weight percentage, comprising: propylene glycol 5%, glycerol 3%, glycine betaine
6%, erythrite 5%, allantoin 0.1%, tara gum 0.2%, Pi Aoning 0.007%, Fermentation in Pichia Pastoris lysis
Object filtrate 15%, phytosterol 2%, 1,2- hexylene glycol 0.4%, Sensiva SC50 0.05%, decoyl hydroximic acid 0.01%,
Water surplus.
Preferably, the anti-acne essence, by weight percentage, comprising: propylene glycol 5%, glycerol 5%, glycine betaine
7%, erythrite 7%, allantoin 0.5%, Scleroglucan 0.6%, tara gum 0.5%, Pi Aoning 0.007%, Pasteur are finished
It is red yeast fermentation lysis object filtrate 20%, phytosterol 5%, 1,2- hexylene glycol 0.5%, Sensiva SC50 0.05%, pungent
Acyl hydroximic acid 0.03%, water surplus.
Preferably, the viscosity of the anti-acne essence is 500-1200Pa.s.
Second aspect, a kind of preparation method of anti-acne essence as described in relation to the first aspect provided by the invention, including such as
Lower step: being previously added water, propylene glycol, glycerol, allantoin in emulsion pot and mix, and be warming up to 85-90 DEG C, is then added small
Pyrenomycetes glue, tara gum, heat preservation homogeneous are stirred to being completely dissolved no granular sensation, then after keeping the temperature 30min, by the temperature in emulsion pot
After being adjusted to not higher than 60 DEG C, Fermentation in Pichia Pastoris lysis object filtrate, glycine betaine, erythrite is added, stirring is completely molten
Temperature in emulsion pot is adjusted to not higher than 45 DEG C, phytosterol, Pi Aoning, 1,2- hexylene glycol, ethyl hexyl is added by Xie Hou
Base glycerol, decoyl hydroximic acid, stir evenly, and anti-acne essence can be obtained through filtering.
The third aspect, the anti-acne essence of one kind provided by the invention as described in relation to the first aspect are preparing answering in cosmetics
With.
It is understood that anyone skilled in the art can be by provided by the invention such as first party
Anti-acne essence described in face is used to prepare in cosmetics, and including but not limited to following method: the anti-acne essence is added
Enter in the cosmetics such as facial cleanser, Essence, cream, cream.
Compared with prior art, the beneficial effects of the present invention are:
(1) anti-acne essence provided by the invention has mild, non-stimulated, without side-effects using obvious effect, performance
Feature；Fermentation in Pichia Pastoris lysis object filtrate, phytosterol and other components in formula of the invention have not
With effective component, it is indispensable, there is the synergistic effect of complementary collaboration, wherein as follows the effect of each component in formula: the third two
Alcohol is polyalcohol, has the function of antimicrobial antiphlogistic and inhibits bacterial proliferation；Glycerol is rich in polysaccharide, and polysaccharide has antibacterial anti-inflammatory, suppression
The effect of silt trace hyperplasia processed；Glycine betaine is a kind of alkaloid, with strong hygroscopicity, good hydrophily；Erythrite is main
Containing ingredients such as volatile oil, alkaloid, organic acids, promote apoptosis of fibroblasts；Allantoin, which has wound surface, promotes healing
Effect；Scleroglucan catechu monkey acid rich in, has the function of stronger inhibition pathogenic microorganism；Tara gum, which has, to be stayed
Natural protective film protection skin is formed in moisture of skin；Fermentation in Pichia Pastoris lysis object filtrate can replace ancient antibiosis
Element has the function of promoting Skin Cell regeneration and wound healing, anti-aging, prevention scar, improves cutaneous immunisation power, also has
Excellent bactericidal effect provides the endogenous wound healing factor for skin, thus improve skin rejecting ambient microorganism ability and
Power is repaired, achievees the effect that anti-acne of quickly reducing swelling；The sterilization of phytosterol, anti-acne effect is obvious and safety is mild；Skin is proud
It is rather the extremely low good anti-acne suppression acne agent of the safe and non-stimulating additive amount of potent sterilization bacteriostat；1,2- hexylene glycol can inhibit bacterium
Growth, moisturizing；Sensiva SC50 can improve the soft and smooth skin sense of formula, be promoted and moisten degree, can effectively inhibit to cause peculiar smell
Bacterial growth breeding, do not influence the bacterium beneficial to human body simultaneously；Decoyl hydroximic acid can prevent Material bacterial infection and micro- life
Object；
(2) anti-acne essence provided by the invention has extremely extensive safety without antibiotic without acute skin irritation
Value；
(3) simple production process of anti-acne essence provided by the invention, it is green safe, there is high economic value；
(4) raw material used in anti-acne essence provided by the invention includes Fermentation in Pichia Pastoris lysis object filtrate
With phytosterol etc., abundance is made full use of and quality-high and inexpensive resource, generate bigger economic and social benefit.
Specific embodiment
Specific embodiments of the present invention will be further explained below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, invention described below
Technical characteristic involved in each embodiment can be combined with each other as long as they do not conflict with each other.
Fermentation in Pichia Pastoris lysis filtrate in following embodiment and comparative example extracts from pichia pastoris yeast
Tunning.
Embodiment 1
A kind of preparation method of anti-acne essence provided in this embodiment includes the following steps:
Take following raw materials in percentage by weight: propylene glycol 2%, glycerol 4%, allantoin 0.2%, Scleroglucan
0.2%, tara gum 0.1%, Pi Aoning 0.007%, Fermentation in Pichia Pastoris lysis object filtrate 10%, phytosterol
3%, glycine betaine 5%, erythrite 4%, 1,2- hexylene glycol 0.3%, Sensiva SC50 0.04%, decoyl hydroximic acid 0.02%,
Water surplus；
Water, propylene glycol, glycerol, allantoin are previously added in emulsion pot and are mixed, and is warming up to 85-90 DEG C, is then added
Scleroglucan, tara gum, heat preservation homogeneous are stirred to being completely dissolved no granular sensation, then after keeping the temperature 30min, by the temperature in emulsion pot
After degree is adjusted to not higher than 60 DEG C, Fermentation in Pichia Pastoris lysis object filtrate, glycine betaine, erythrite is added, stirring is complete
After dissolution, the temperature in emulsion pot is adjusted to not higher than 45 DEG C, phytosterol, Pi Aoning, 1,2- hexylene glycol, ethyl is added
Hexyl glycerol, decoyl hydroximic acid, stir evenly, and 200 mesh filter clothes can be obtained anti-acne essence and (measure viscosity in 500- excessively
Within the scope of 1200Pa.s).
Embodiment 2
Anti-acne essence, the difference of the present embodiment and embodiment 1 is prepared according to preparation method similar to Example 1
It is that raw material is different, the raw material of the present embodiment 2, in percentage by weight, comprising: propylene glycol 5%, glycerol 3%, allantoin
0.1%, tara gum 0.2%, Pi Aoning 0.007%, Fermentation in Pichia Pastoris lysis object filtrate 15%, phytosterol
2%, glycine betaine 6%, erythrite 5%, 1,2- hexylene glycol 0.4%, Sensiva SC50 0.05%, decoyl hydroximic acid 0.01%,
Water surplus (measures viscosity within the scope of 500-1200Pa.s).
Embodiment 3
Anti-acne essence, the difference of the present embodiment and embodiment 1 is prepared according to preparation method similar to Example 1
It is that raw material is different, the raw material of the present embodiment 3, in percentage by weight, comprising: propylene glycol 5%, glycerol 5%, allantoin
0.5%, Scleroglucan 0.6%, tara gum 0.5%, Pi Aoning 0.007%, Fermentation in Pichia Pastoris lysis object filtrate
20%, phytosterol 5%, glycine betaine 7%, erythrite 7%, 1,2- hexylene glycol 0.5%, Sensiva SC50 0.05%, pungent
Acyl hydroximic acid 0.03%, water surplus (measuring viscosity within the scope of 500-1200Pa.s).
Embodiment 4
Anti-acne essence, the difference of the present embodiment and embodiment 1 is prepared according to preparation method similar to Example 1
It is that raw material is different, the raw material of the present embodiment 4, in percentage by weight, comprising: propylene glycol 1%, glycerol 6%, glycine betaine
7%, erythrite 3%, allantoin 1%, Scleroglucan 1%, tara gum 1%, Pi Aoning 0.007%, pichia pastoris yeast
Fermentation lysis object filtrate 25%, phytosterol 1%, 1,2- hexylene glycol 0.1%, base hexyl glycerol 0.01%, decoyl hydroxyl oxime
Sour 0.1%, water surplus (measuring viscosity within the scope of 500-1200Pa.s).
Embodiment 5
Anti-acne essence, the difference of the present embodiment and embodiment 1 is prepared according to preparation method similar to Example 1
It is that raw material is different, the raw material of the present embodiment 5, in percentage by weight, comprising: propylene glycol 10%, glycerol 10%, glycine betaine
10%, erythrite 1%, allantoin 0.1%, Scleroglucan 2%, tara gum 0.1%, Pi Aoning 0.007%, Pasteur are finished red
Yeast fermentation lysis object filtrate 5%, phytosterol 1%, 1,2- hexylene glycol 0.1%, base hexyl glycerol 0.01%, decoyl hydroxyl
Oxime acid 0.01%, water surplus (measuring viscosity within the scope of 500-1200Pa.s).
Embodiment 6
Anti-acne essence, the difference of the present embodiment and embodiment 1 is prepared according to preparation method similar to Example 1
It is that raw material is different, the raw material of the present embodiment 6, in percentage by weight, comprising: propylene glycol 1%, glycerol 2%, glycine betaine
1%, erythrite 10%, allantoin 2%, Scleroglucan 0.1%, tara gum 2%, Pi Aoning 0.007%, Pasteur finish red ferment
Mother fermentation lysis object filtrate 25%, phytosterol 10%, 1,2- hexylene glycol 2%, base hexyl glycerol 0.1%, decoyl hydroxyl oxime
Sour 0.1%, water surplus (measuring viscosity within the scope of 500-1200Pa.s).
Comparative example 1
Beneficial effect in order to further illustrate the present invention is prepared according to preparation method similar to Example 1 and dispels
Acne Essence, this comparative example is the difference from embodiment 1 is that raw material is different, the raw material of this comparative example 1, by weight percentage,
Include: propylene glycol 2%, glycerol 4%, allantoin 0.2%, Scleroglucan 0.2%, tara gum 0.1%, Pi Aoning 0.007%,
Phytosterol 3%, glycine betaine 5%, erythrite 4%, 1,2- hexylene glycol 0.3%, Sensiva SC50 0.04%, decoyl hydroxyl oxime
Sour 0.02%, water surplus.
Comparative example 2
Beneficial effect in order to further illustrate the present invention is prepared according to preparation method similar to Example 1 and dispels
Acne Essence, this comparative example is the difference from embodiment 1 is that raw material is different, the raw material of this comparative example 1, by weight percentage,
Include: propylene glycol 2%, glycerol 4%, allantoin 0.2%, Scleroglucan 0.2%, tara gum 0.1%, Pi Aoning 0.007%,
Fermentation in Pichia Pastoris lysis object filtrate 10%, glycine betaine 5%, erythrite 4%, 1,2- hexylene glycol 0.3%, ethylhexyl
Glycerol 0.04%, decoyl hydroximic acid 0.02%, water surplus.
Comparative example 3
Beneficial effect in order to further illustrate the present invention is prepared according to preparation method similar to Example 1 and dispels
Acne Essence, this comparative example is the difference from embodiment 1 is that raw material is different, the raw material of this comparative example 1, by weight percentage,
It include: propylene glycol 2%, glycerol 4%, allantoin 0.2%, tara gum 0.1%, Pi Aoning 0.007%, pichia pastoris yeast
Fermentation lysis object filtrate 10%, phytosterol 3%, glycine betaine 5%, erythrite 4%, 1,2- hexylene glycol 0.3%, ethylhexyl
Glycerol 0.04%, decoyl hydroximic acid 0.02%, water surplus.
Comparative example 4
Beneficial effect in order to further illustrate the present invention is prepared according to preparation method similar to Example 1 and dispels
Acne Essence, this comparative example is the difference from embodiment 1 is that raw material is different, the raw material of this comparative example 1, by weight percentage,
Include: propylene glycol 2%, glycerol 4%, allantoin 0.2%, Scleroglucan 0.2%, tara gum 0.1%, Pi Aoning 0.007%,
Fermentation in Pichia Pastoris lysis object filtrate 10%, phytosterol 3%, glycine betaine 5%, erythrite 4%, 1,2- hexylene glycol
0.3%, Sensiva SC50 0.04%, decoyl hydroximic acid 0.02%, water surplus.
Comparative example 5
Beneficial effect in order to further illustrate the present invention, by " Fermentation in Pichia Pastoris lysis object is filtered in embodiment 1
Liquid " is substituted for " beer yeast fermenting lysis object filtrate ", and anti-acne essence is made in the preparation method for repeating embodiment 1.
Comparative example 6
Beneficial effect in order to further illustrate the present invention, by " Fermentation in Pichia Pastoris lysis object is filtered in embodiment 1
Liquid " is substituted for " fermentation by saccharomyces cerevisiae lysis object filtrate ", and anti-acne essence is made in the preparation method for repeating embodiment 1.
Effect example 1
The product and commercially available acne removal stock liquid of Example and comparative example, a commercially available clear clear acne condensation of hall, do following clinic
Test:
According to the ratio of men and women 1:1, selects the age in 18-22 years old volunteer, be divided into 25 people/group, totally 14 groups；Each group from
After hope person washes one's face with warm water, anti-acne condensation 2ml or so is taken respectively, and after thorough cleaning skin, anti-acne condensation is uniformly applied to skin
On skin, once a day, specific grouping is referring to table 1 for aforesaid operations.With the calculating of whelk number, records it and dispel 50% quantity
Whelk spent time (that is, average anti-acne half period), and the healing state of the pockmark in affected part is observed, after whelk is eliminated, system
The quantity that meter pockmark is dispelled, the cure rate of pockmark is obtained by calculating；Test result is referring to table 1.
1 anti-acne effect test result of table
Interpretation of result: as the test result in table 1 it is found that the use of anti-acne essence obtained by using Examples 1 to 6
The anti-acne effect of person is significantly better than product and commercially available similar product obtained by comparative example, wherein dispels obtained by embodiment 1
The anti-acne effect of acne Essence is best, and the average anti-acne half period is 7 days, and healing rate reaches 88%, this illustrates anti-acne of the invention
Fermentation in Pichia Pastoris lysis object filtrate, phytosterol and other components in essence formula of liquid have different effects
Ingredient has the synergistic effect of complementary collaboration.
Above the embodiments of the present invention are described in detail, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (8)
1. a kind of anti-acne essence, which is characterized in that by weight percentage, comprising: propylene glycol 1-10%, glycerol 2-10%,
Glycine betaine 1-10%, erythrite 1-10%, allantoin 0.1-2%, Scleroglucan 0.1-2%, tara gum 0.1-2%, skin are proud
Peaceful 0.001~0.01%, Fermentation in Pichia Pastoris lysis object filtrate 5-25%, phytosterol 1-10%, 1,2- oneself two
Alcohol 0.1-2%, base hexyl glycerol 0.01-0.1%, decoyl hydroximic acid 0.01-0.1%, water surplus.
2. anti-acne essence according to claim 1, which is characterized in that the anti-acne essence, by weight percentage,
It include: propylene glycol 2-5%, glycerol 3-5%, glycine betaine 2-7%, erythrite 2-7%, allantoin 0.1-0.5%, Scleroglucan
0.1-0.6%, tara gum 0.1-0.5%, Pi Aoning 0.001~0.01%, Fermentation in Pichia Pastoris lysis object filtrate
5-25%, phytosterol 2-5%, 1,2- hexylene glycol 0.1-0.5%, base hexyl glycerol 0.01-0.05%, decoyl hydroximic acid
0.01-0.03%, water surplus.
3. anti-acne essence according to claim 1, which is characterized in that the anti-acne essence, by weight percentage,
It include: propylene glycol 2%, glycerol 4%, glycine betaine 5%, erythrite 4%, allantoin 0.2%, Scleroglucan 0.2%, tara gum
0.1%, Pi Aoning 0.007%, Fermentation in Pichia Pastoris lysis object filtrate 10%, phytosterol 3%, 1,2- hexylene glycol
0.3%, Sensiva SC50 0.04%, decoyl hydroximic acid 0.02%, water surplus.
4. anti-acne essence according to claim 1, which is characterized in that the anti-acne essence, by weight percentage,
It include: propylene glycol 5%, glycerol 3%, glycine betaine 6%, erythrite 5%, allantoin 0.1%, tara gum 0.2%, Pi Aoning
0.007%, Fermentation in Pichia Pastoris lysis object filtrate 15%, phytosterol 2%, 1,2- hexylene glycol 0.4%, ethyl hexyl
Base glycerol 0.05%, decoyl hydroximic acid 0.01%, water surplus.
5. anti-acne essence according to claim 1, which is characterized in that the anti-acne essence, by weight percentage,
It include: propylene glycol 5%, glycerol 5%, glycine betaine 7%, erythrite 7%, allantoin 0.5%, Scleroglucan 0.6%, tara gum
0.5%, Pi Aoning 0.007%, Fermentation in Pichia Pastoris lysis object filtrate 25%, phytosterol 5%, 1,2- hexylene glycol
0.5%, Sensiva SC50 0.05%, decoyl hydroximic acid 0.03%, water surplus.
6. anti-acne essence according to claim 1, which is characterized in that the viscosity of the anti-acne essence is 500-
1200Pa.s。
7. a kind of preparation method of anti-acne essence as described in any one of claims 1 to 6, which is characterized in that including as follows
Step: water, propylene glycol, glycerol, allantoin are previously added in emulsion pot and are mixed, and is warming up to 85-90 DEG C, small nut is then added
Bacterium glue, tara gum, heat preservation homogeneous are stirred to being completely dissolved no granular sensation, then after keeping the temperature 30min, by the temperature tune in emulsion pot
Fermentation in Pichia Pastoris lysis object filtrate, glycine betaine, erythrite is added to after not higher than 60 DEG C in section, and stirring is completely dissolved
Afterwards, the temperature in emulsion pot is adjusted to not higher than 45 DEG C, phytosterol, Pi Aoning, 1,2- hexylene glycol, ethylhexyl is added
Glycerol, decoyl hydroximic acid, stir evenly, and anti-acne essence can be obtained through filtering.
8. a kind of if anti-acne essence according to any one of claims 1 to 6 is in the application prepared in cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811421998.7A CN109394594A (en) | 2018-11-27 | 2018-11-27 | A kind of anti-acne essence and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811421998.7A CN109394594A (en) | 2018-11-27 | 2018-11-27 | A kind of anti-acne essence and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109394594A true CN109394594A (en) | 2019-03-01 |
Family
ID=65455676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811421998.7A Withdrawn CN109394594A (en) | 2018-11-27 | 2018-11-27 | A kind of anti-acne essence and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109394594A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358742A (en) * | 2020-05-15 | 2020-07-03 | 广州比力福生物科技有限公司 | Compound plant anti-hair loss and hair growth liquid |
| CN111991288A (en) * | 2020-08-28 | 2020-11-27 | 广东鑫美鑫化妆品有限公司 | Acne removing essence and preparation method and application thereof |
| CN113398028A (en) * | 2021-07-07 | 2021-09-17 | 广州天然国度生物科技有限公司 | Smoothing toner capable of adjusting micro-ecological balance of skin and preparation method thereof |
| CN114478814A (en) * | 2022-01-24 | 2022-05-13 | 上海浩泰生物科技有限公司 | High-transparency Caesalpinia spinosa adhesive and preparation method and application thereof |
| CN115074393A (en) * | 2022-08-04 | 2022-09-20 | 江苏创健医疗科技有限公司 | Pichia pastoris fermentation lysate filtrate, preparation method and application |
-
2018
- 2018-11-27 CN CN201811421998.7A patent/CN109394594A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358742A (en) * | 2020-05-15 | 2020-07-03 | 广州比力福生物科技有限公司 | Compound plant anti-hair loss and hair growth liquid |
| CN111991288A (en) * | 2020-08-28 | 2020-11-27 | 广东鑫美鑫化妆品有限公司 | Acne removing essence and preparation method and application thereof |
| CN113398028A (en) * | 2021-07-07 | 2021-09-17 | 广州天然国度生物科技有限公司 | Smoothing toner capable of adjusting micro-ecological balance of skin and preparation method thereof |
| CN114478814A (en) * | 2022-01-24 | 2022-05-13 | 上海浩泰生物科技有限公司 | High-transparency Caesalpinia spinosa adhesive and preparation method and application thereof |
| CN114478814B (en) * | 2022-01-24 | 2022-09-27 | 上海浩泰生物科技有限公司 | High-transparency Caesalpinia spinosa adhesive and preparation method and application thereof |
| CN115074393A (en) * | 2022-08-04 | 2022-09-20 | 江苏创健医疗科技有限公司 | Pichia pastoris fermentation lysate filtrate, preparation method and application |
| CN115074393B (en) * | 2022-08-04 | 2023-11-21 | 江苏创健医疗科技股份有限公司 | Pichia pastoris fermentation lysate filtrate, preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109394594A (en) | A kind of anti-acne essence and its preparation method and application | |
| WO2018040415A1 (en) | Deep replenishing and moisturizing face cleanser | |
| CN108969424B (en) | Mild anti-dandruff itching-relieving composition and preparation method and application thereof | |
| CN112353750A (en) | Hemp leaf soothing and repairing essence and preparation method thereof | |
| EP3552599A1 (en) | Composition containing crocus sativus extract and preparation method and use thereof | |
| JP6894991B2 (en) | Cosmetic composition containing mint vinegar as an active ingredient | |
| CN102415974B (en) | Rose-water-containing astringent and preparation method thereof | |
| CN107362121A (en) | A kind of anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing | |
| CN109172422B (en) | Hyaluronic acid mask liquid and preparation method thereof | |
| CN104248548A (en) | Plant extract-containing oxidation-resistant essence | |
| CN112315840A (en) | Mussel mucin scalp repair composition, repair liquid and preparation method thereof | |
| CN110613671A (en) | Dendrobium officinale essence milk and preparation method thereof | |
| CN104873447A (en) | Peach-blossom sleep facial mask and preparation method therefor | |
| CN109589283B (en) | Fat-endowing agent with skin barrier repairing function and application thereof | |
| CN111643424A (en) | Dendrobium officinale repair water and processing technology thereof | |
| CN115054565A (en) | Soothing repair cream for constructing skin barrier | |
| CN110664720A (en) | Dendrobium officinale essence lotion and preparation method thereof | |
| CN110025515B (en) | Anti-allergy polysaccharide compound composition and application thereof in cosmetics | |
| CN109528569B (en) | Skin conditioning composition with cell repairing function, cell repairing essence and preparation method thereof | |
| CN112933022A (en) | Composition for controlling oil and activating skin of face, preparation method and application | |
| CN106539702A (en) | A kind of fibroin reduction frost and preparation method thereof | |
| CN111454797A (en) | Grape seed oil red wine handmade soap and preparation method thereof | |
| CN112656747A (en) | Anti-hair loss lotion and preparation method thereof | |
| CN110897950A (en) | Facial mask with anti-inflammatory, moisturizing and whitening effects and preparation method thereof | |
| CN111743825A (en) | Moisturizing and skin-tendering body lotion and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190301 |
|
| WW01 | Invention patent application withdrawn after publication |