CN109330065B - Antibacterial gloves for hemodialysis nursing and preparation method thereof - Google Patents
Antibacterial gloves for hemodialysis nursing and preparation method thereof Download PDFInfo
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- CN109330065B CN109330065B CN201811300351.9A CN201811300351A CN109330065B CN 109330065 B CN109330065 B CN 109330065B CN 201811300351 A CN201811300351 A CN 201811300351A CN 109330065 B CN109330065 B CN 109330065B
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- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D19/00—Gloves
- A41D19/0055—Plastic or rubber gloves
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
- C08G69/28—Preparatory processes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
- C08J7/14—Chemical modification with acids, their salts or anhydrides
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D2500/00—Materials for garments
- A41D2500/50—Synthetic resins or rubbers
- A41D2500/52—Synthetic resins or rubbers in sheet form
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2377/00—Characterised by the use of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Derivatives of such polymers
- C08J2377/06—Polyamides derived from polyamines and polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2423/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2423/26—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers modified by chemical after-treatment
- C08J2423/32—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers modified by chemical after-treatment by reaction with phosphorus- or sulfur-containing compounds
- C08J2423/34—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers modified by chemical after-treatment by reaction with phosphorus- or sulfur-containing compounds by chlorosulfonation
Abstract
The invention discloses a preparation method of an antibacterial glove for hemodialysis nursing, which comprises the following steps: preparing 1, 2-diamino-5-trifluoromethyl benzimidazole amide of polythia diacid; (II) forming gloves; and (III) ion exchange. The invention also discloses the antibacterial gloves for hemodialysis care prepared according to the preparation method of the antibacterial gloves for hemodialysis care. The antibacterial glove for hemodialysis nursing disclosed by the invention is good in biocompatibility, excellent in mechanical property, wear resistance, ageing resistance, antistatic property, antibacterial property and infection resistance, good in anticoagulation and antithrombotic property, and safe and reliable to use.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to an antibacterial glove for hemodialysis nursing and a preparation method thereof.
Background
With the progress of the times and the development of scientific technology, hemodialysis technology is mature more and more, and hemodialysis is one of the main ways of renal replacement therapy for patients with acute and chronic renal failure in clinic. The blood and electrolyte solution (dialysate) with similar concentration of organism are arranged inside and outside the hollow fiber by draining the blood in vivo to the outside of the body and passing through a dialyzer consisting of a plurality of hollow fibers, and the function of a semipermeable membrane is utilized to exchange substances by dispersion/convection, thereby removing metabolic waste in the body and maintaining the balance of electrolyte and acid-base; and simultaneously, excessive water in the body is removed, so that the blood purification effect is achieved.
In the hemodialysis process, in order to prevent complications caused by infection and prevent contact transmission of bacteria or germs, the using amount and the demand of the nursing gloves are increasing, people have higher and higher requirements on the nursing gloves, the nursing gloves are required to have good wear resistance and elasticity, excellent wear resistance, aging resistance, static resistance, bacteria resistance and infection resistance, good biocompatibility and no anaphylactic reaction to skin, and the nursing gloves can play a role in resisting blood coagulation and thrombus during hemodialysis nursing.
Most of medical gloves in the prior art adopt natural latex and butyronitrile as materials, the materials are easy to cause anaphylactic reaction to skin, the antibacterial and anti-infection performance is poor, an additive added in the preparation process is toxic and harmful to human bodies, harm is easily caused to the environment and the health of wearers, and anaphylactic reaction is caused to the skin.
Therefore, the development of the antibacterial glove for hemodialysis care, which has the advantages of mechanical and mechanical properties, good wear resistance, aging resistance, static resistance, bacteria resistance, infection resistance, biocompatibility, anticoagulation and thrombosis resistance, is safe and reliable to use, meets the market demand, and has wide market value and clinical application prospect.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide an antibacterial glove for hemodialysis nursing, which has the advantages of good biocompatibility, excellent mechanical property, wear resistance, ageing resistance, static resistance, bacteria resistance, infection resistance, excellent anticoagulation and thrombus resistance, and safe and reliable use, so as to effectively solve the technical problems of insufficient tearing resistance, easy allergic reaction to skin, poor bacteria resistance and infection resistance, toxic and harmful auxiliary agents added in the preparation process to human bodies, and easy infection to cause inflammatory reaction in the conventional medical gloves, and also provides a preparation method thereof.
The invention is realized by the following scheme:
a preparation method of antibacterial gloves for hemodialysis care comprises the following steps:
preparation of polythionic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide: adding thiadioic acid and 1, 2-diamino-5-trifluoromethyl benzimidazole into a high boiling point solvent, adding dicyclohexylcarbodiimide, 4-dimethylaminopyridine and tetrabutylammonium bromide into the solvent, stirring the mixture to react and separate out, and drying the mixture to obtain the 1, 2-diamino-5-trifluoromethyl benzimidazole amide;
II, forming gloves: uniformly mixing powdery chlorosulfonated polyethylene and polythiadioic acid 1, 2-diamino-5-trifluoromethyl benzimidazole amide, and processing the mixture into antibacterial gloves;
III, ion exchange: and (3) soaking the antibacterial gloves in a glycyrrhizic acid aqueous solution for ion exchange, and washing and drying to obtain the antibacterial gloves for hemodialysis nursing.
Further, the steps included may be subdivided into:
preparation of polythionic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide: adding thia-diacid and 1, 2-diamino-5-trifluoromethyl benzimidazole into a high boiling point solvent, adding dicyclohexyl carbodiimide, 4-dimethylamino pyridine and tetrabutyl ammonium bromide into the solvent, stirring the mixture to react for 2 to 3 hours at the temperature of 90 to 110 ℃ under the atmosphere of nitrogen or inert gas, stirring the mixture to react for 8 to 10 hours at the temperature of 125 ℃ and 135 ℃, separating out the product in water after the reaction is finished, washing the separated product with ethanol for 3 to 5 times, and drying the product in a vacuum drying oven at the temperature of 80 to 90 ℃ to constant weight to obtain the 1, 2-diamino-5-trifluoromethyl benzimidazole amide of the poly-thia-diacid;
II, forming gloves: grinding chlorosulfonated polyethylene into powder in a ball mill, adding the powder into the powder to prepare the polythiadic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide through the step I, adding the mixture into a vacuum kneading machine or an internal mixer to be uniformly mixed, forming the mixture through an open mill, and finally putting the formed material into a glove forming machine to form the antibacterial gloves;
III, ion exchange: and (3) soaking the antibacterial gloves prepared in the step (II) in a glycyrrhizic acid water solution with the mass fraction of 5-10% at the temperature of 50-60 ℃ for 20-30 hours, washing with water for 3-5 times, and drying in a vacuum drying oven at the temperature of 80-90 ℃ to constant weight to obtain the antibacterial gloves for hemodialysis nursing.
Preferably, the mass ratio of the thiadioic acid, the 1, 2-diamino-5-trifluoromethylbenzimidazole, the high-boiling-point solvent, the dicyclohexylcarbodiimide, the 4-dimethylaminopyridine and the tetrabutylammonium bromide in the step I is 1:1.22 (10-15): 0.4-0.6: 0.3: 0.1.
Preferably, the high boiling point solvent is selected from one or more of dimethyl sulfoxide, N-dimethylformamide and N-methylpyrrolidone.
Preferably, the inert gas is selected from one of helium, neon and argon.
Preferably, the mass ratio of the chlorosulfonated polyethylene to the polythiadioic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide in the step II is 1 (2-3).
An antibacterial glove for hemodialysis care is prepared by the preparation method of the antibacterial glove for hemodialysis care.
Preferably, the antibacterial gloves for hemodialysis care are used for hemodialysis care.
Adopt the produced beneficial effect of above-mentioned technical scheme to lie in:
1) the preparation method of the antibacterial gloves for hemodialysis nursing, provided by the invention, is simple and easy to operate, mild in reaction conditions, easy to obtain raw materials, low in price and good in clinical practicability.
2) The antibacterial gloves for hemodialysis nursing effectively solve the technical problems that the traditional medical gloves are poor in tear resistance, easy to cause anaphylactic reaction to skin and poor in antibacterial and infection prevention performance, and additives added in the preparation process are toxic and harmful to human bodies and easy to infect to cause inflammatory reaction.
3) The antibacterial gloves for hemodialysis nursing are formed by blending the polythiadic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide and chlorosulfonated polyethylene, the advantages of two polymers are taken into consideration, and the two polymers react with imidazole ring through chlorine to form imidazole salt, so that the antibacterial property and the antistatic property of the gloves are improved, and the antibacterial gloves have a synergistic effect with thiazole on the main chain of the polythiadic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide, so that the gloves can prevent infection and prevent contact type transmission of viruses and bacteria; the glycyrrhiza uralensis radical is introduced through ion exchange, so that the biocompatibility is improved, the allergic stimulation to the skin is reduced, the antithrombotic and anticoagulant effects can be achieved, and the clinical practicability is high in hemodialysis nursing; the two polymers form a three-dimensional network structure through chemical reaction, so that the comprehensive performance of the glove is improved.
Detailed Description
In order to make the technical solutions of the present invention better understood and make the above features, objects, and advantages of the present invention more comprehensible, the present invention is further described with reference to the following examples. The examples are intended to illustrate the invention only and are not intended to limit the scope of the invention.
The raw materials in the following examples of the present invention were obtained from Shanghai spring Xin import & export trade company, Inc.
Example 1
A preparation method of antibacterial gloves for hemodialysis care comprises the following steps:
preparation of polythionic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide: adding 1kg of thia-dizoic acid and 1.22kg of 1, 2-diamino-5-trifluoromethyl benzimidazole into 10kg of dimethyl sulfoxide, adding 0.4kg of dicyclohexylcarbodiimide, 0.3kg of 4-dimethylaminopyridine and 0.1kg of tetrabutylammonium bromide into the dimethyl sulfoxide, stirring the mixture to react for 2 hours at 90 ℃ under the nitrogen atmosphere, stirring the mixture to react for 8 hours at 125 ℃, separating out the product in water after the reaction is finished, washing the separated product for 3 times by using ethanol, and drying the product in a vacuum drying oven at 80 ℃ to constant weight to obtain the 1, 2-diamino-5-trifluoromethyl benzimidazole amide;
II, forming gloves: grinding 0.5kg of chlorosulfonated polyethylene into powder in a ball mill, then adding 1kg of the 1, 2-diamino-5-trifluoromethyl benzimidazole amide which is prepared by the step I, adding the mixture into a vacuum kneader, uniformly mixing, then forming by an open mill, and finally putting the forming material into a glove forming machine to form the antibacterial gloves;
III, ion exchange: and (3) soaking the antibacterial gloves prepared in the step (II) in a glycyrrhizic acid water solution with the mass fraction of 5% at the temperature of 50 ℃ for 20 hours, washing with water for 3 times, and drying in a vacuum drying oven at the temperature of 80 ℃ to constant weight to obtain the antibacterial gloves for hemodialysis nursing.
An antibacterial glove for hemodialysis care is prepared by the preparation method of the antibacterial glove for hemodialysis care.
The antibacterial gloves for hemodialysis care are used for hemodialysis care.
Example 2
A preparation method of antibacterial gloves for hemodialysis care comprises the following steps:
preparation of polythionic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide: adding 1kg of thiadioic acid and 1.22kg of 1, 2-diamino-5-trifluoromethylbenzimidazole into 11kg of N, N-dimethylformamide, adding 0.45kg of dicyclohexylcarbodiimide, 0.3kg of 4-dimethylaminopyridine and 0.1kg of tetrabutylammonium bromide into the N, N-dimethylformamide, stirring and reacting for 2.3 hours at 95 ℃ under the atmosphere of helium, stirring and reacting for 8.5 hours at 127 ℃, separating out the thiadioic acid from water after the reaction is finished, washing the separated product for 4 times by using ethanol, and drying the mixture in a vacuum drying oven at 83 ℃ to constant weight to obtain the 1, 2-diamino-5-trifluoromethylbenzimidazole amide;
II, forming gloves: grinding 0.5kg of chlorosulfonated polyethylene into powder in a ball mill, then adding 1.1kg of 1, 2-diamino-5-trifluoromethyl benzimidazole amide which is used for preparing the polythiadioic acid in the step I, adding the mixture into an internal mixer to be uniformly mixed, then forming the mixture by an open mill, and finally putting the forming material into a glove forming machine to form the antibacterial gloves;
III, ion exchange: and (3) soaking the antibacterial gloves prepared in the step (II) in 6% glycyrrhizic acid water solution at the temperature of 53 ℃ for 23 hours, washing with water for 4 times, and drying in a vacuum drying oven at 83 ℃ to constant weight to obtain the antibacterial gloves for hemodialysis nursing.
An antibacterial glove for hemodialysis care is prepared by the preparation method of the antibacterial glove for hemodialysis care.
The antibacterial gloves for hemodialysis care are used for hemodialysis care.
Example 3
A preparation method of antibacterial gloves for hemodialysis care comprises the following steps:
preparation of polythionic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide: adding 1kg of thiadioic acid and 1.22kg of 1, 2-diamino-5-trifluoromethylbenzimidazole into 13kg of N-methylpyrrolidone, adding 0.5kg of dicyclohexylcarbodiimide, 0.3kg of 4-dimethylaminopyridine and 0.1kg of tetrabutylammonium bromide, stirring and reacting for 2.5 hours at 100 ℃ under the atmosphere of neon, stirring and reacting for 9 hours at 130 ℃, separating out in water after the reaction is finished, washing the separated product for 4 times by using ethanol, and drying in a vacuum drying oven at 85 ℃ until the weight is constant to obtain the 1, 2-diamino-5-trifluoromethylbenzimidazole amide;
II, forming gloves: grinding 0.5kg of chlorosulfonated polyethylene into powder in a ball mill, then adding 1.3kg of the 1, 2-diamino-5-trifluoromethyl benzimidazole amide which is prepared by the step I, adding the mixture into a vacuum kneader, uniformly mixing, then forming by an open mill, and finally putting the forming material into a glove forming machine to form the antibacterial gloves;
III, ion exchange: and (3) soaking the antibacterial gloves prepared in the step (II) in a glycyrrhizic acid water solution with the mass fraction of 7% at the temperature of 56 ℃ for 27 hours, washing with water for 4 times, and drying in a vacuum drying oven at the temperature of 85 ℃ to constant weight to obtain the antibacterial gloves for hemodialysis nursing.
An antibacterial glove for hemodialysis care is prepared by the preparation method of the antibacterial glove for hemodialysis care.
The antibacterial gloves for hemodialysis care are used for hemodialysis care.
Example 4
A preparation method of antibacterial gloves for hemodialysis care comprises the following steps:
preparation of polythionic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide: adding 1kg of thiadioic acid and 1.22kg of 1, 2-diamino-5-trifluoromethylbenzimidazole into 14kg of high boiling point solvent, adding 0.55kg of dicyclohexylcarbodiimide, 0.3kg of 4-dimethylaminopyridine and 0.1kg of tetrabutylammonium bromide into the solvent, stirring and reacting for 2.8 hours at 105 ℃ under the argon atmosphere, stirring and reacting for 9.5 hours at 133 ℃, separating out the thiadioic acid from the solvent in water after the reaction is finished, washing the separated product for 5 times by using ethanol, and drying the product in a vacuum drying oven at 88 ℃ to constant weight to obtain the 1, 2-diamino-5-trifluoromethylbenzimidazole amide; the high-boiling-point solvent is a mixture formed by mixing dimethyl sulfoxide, N-dimethylformamide and N-methylpyrrolidone according to the mass ratio of 2:1: 2;
II, forming gloves: grinding 0.5kg of chlorosulfonated polyethylene into powder in a ball mill, then adding 1.4kg of 1, 2-diamino-5-trifluoromethyl benzimidazole amide which is used for preparing the polythiadioic acid in the step I, adding the mixture into an internal mixer to be uniformly mixed, then forming the mixture by an open mill, and finally putting the forming material into a glove forming machine to form the antibacterial gloves;
III, ion exchange: and (3) soaking the antibacterial gloves prepared in the step (II) in a glycyrrhizic acid water solution with the mass fraction of 9% at the temperature of 58 ℃ for 28 hours, then washing with water for 5 times, and drying in a vacuum drying oven at the temperature of 89 ℃ to constant weight to obtain the antibacterial gloves for hemodialysis nursing.
An antibacterial glove for hemodialysis care is prepared by the preparation method of the antibacterial glove for hemodialysis care.
The antibacterial gloves for hemodialysis care are used for hemodialysis care.
Example 5
A preparation method of antibacterial gloves for hemodialysis care comprises the following steps:
preparation of polythionic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide: adding 1kg of thia-dizoic acid and 1.22kg of 1, 2-diamino-5-trifluoromethyl benzimidazole into 15kg of dimethyl sulfoxide, adding 0.6kg of dicyclohexylcarbodiimide, 0.3kg of 4-dimethylaminopyridine and 0.1kg of tetrabutylammonium bromide into the dimethyl sulfoxide, stirring the mixture to react for 3 hours at 110 ℃ under the nitrogen atmosphere, stirring the mixture to react for 10 hours at 135 ℃, separating out the product in water after the reaction is finished, washing the separated product for 5 times by using ethanol, and drying the product in a vacuum drying oven at 90 ℃ to constant weight to obtain the 1, 2-diamino-5-trifluoromethyl benzimidazole amide;
II, forming gloves: grinding 0.5kg of chlorosulfonated polyethylene into powder in a ball mill, then adding 1.5kg of the 1, 2-diamino-5-trifluoromethyl benzimidazole amide which is prepared by the step I, adding the mixture into a vacuum kneader, uniformly mixing, then forming by an open mill, and finally putting the forming material into a glove forming machine to form the antibacterial gloves;
III, ion exchange: and (3) soaking the antibacterial gloves prepared in the step (II) in a glycyrrhizic acid water solution with the mass fraction of 10% at the temperature of 60 ℃ for 30 hours, then washing with water for 5 times, and drying in a vacuum drying oven at the temperature of 90 ℃ to constant weight to obtain the antibacterial gloves for hemodialysis nursing.
An antibacterial glove for hemodialysis care is prepared by the preparation method of the antibacterial glove for hemodialysis care.
The antibacterial gloves for hemodialysis care are used for hemodialysis care.
Comparative example
Commercially available nitrile gloves available from Haiman, Inc.
The performance of the antibacterial gloves for hemodialysis care prepared in examples 1 to 5 and the nitrile gloves of comparative example were tested, and the test methods and test results are shown in table 1.
TABLE 1
As can be seen from table 1, the antibacterial gloves for hemodialysis care disclosed by the invention have more excellent mechanical properties, antibacterial properties and biocompatibility.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. A preparation method of antibacterial gloves for hemodialysis nursing is characterized by comprising the following steps:
preparation of polythionic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide: adding thia-diacid and 1, 2-diamino-5-trifluoromethyl benzimidazole into a high boiling point solvent, adding dicyclohexyl carbodiimide, 4-dimethylamino pyridine and tetrabutyl ammonium bromide into the solvent, stirring the mixture to react for 2 to 3 hours at the temperature of 90 to 110 ℃ under the atmosphere of nitrogen or inert gas, stirring the mixture to react for 8 to 10 hours at the temperature of 125 ℃ and 135 ℃, separating out the product in water after the reaction is finished, washing the separated product with ethanol for 3 to 5 times, and drying the product in a vacuum drying oven at the temperature of 80 to 90 ℃ to constant weight to obtain the 1, 2-diamino-5-trifluoromethyl benzimidazole amide of the poly-thia-diacid;
II, forming gloves: grinding chlorosulfonated polyethylene into powder in a ball mill, adding the powder into the powder to prepare the polythiadic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide through the step I, adding the mixture into a vacuum kneading machine or an internal mixer to be uniformly mixed, forming the mixture through an open mill, and finally putting the formed material into a glove forming machine to form the antibacterial gloves;
III, ion exchange: soaking the antibacterial gloves prepared in the step II in a glycyrrhizic acid aqueous solution with the mass fraction of 5-10% at the temperature of 50-60 ℃ for 20-30 hours, then washing with water for 3-5 times, and drying in a vacuum drying oven at the temperature of 80-90 ℃ to constant weight to obtain the antibacterial gloves for hemodialysis nursing;
wherein the mass ratio of the thiadioic acid, the 1, 2-diamino-5-trifluoromethyl benzimidazole, the high-boiling point solvent, the dicyclohexylcarbodiimide, the 4-dimethylamino pyridine and the tetrabutylammonium bromide in the step I is 1:1.22 (10-15): 0.4-0.6: 0.3: 0.1;
in the step II, the mass ratio of the chlorosulfonated polyethylene to the polythiadioic acid 1, 2-diamino-5-trifluoromethylbenzimidazole amide is 1 (2-3).
2. The method for preparing antibacterial gloves for hemodialysis care according to claim 1, wherein the high boiling point solvent is one or more selected from dimethylsulfoxide, N-dimethylformamide, and N-methylpyrrolidone.
3. The method of manufacturing antimicrobial gloves for hemodialysis treatment according to claim 1, wherein the inert gas is one selected from helium, neon, and argon.
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| CN201811300351.9A CN109330065B (en) | 2018-11-02 | 2018-11-02 | Antibacterial gloves for hemodialysis nursing and preparation method thereof |
| CN202010186496.1A CN111418934A (en) | 2018-11-02 | 2018-11-02 | Antibacterial glove for hemodialysis nursing |
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| CN107298826A (en) * | 2017-07-30 | 2017-10-27 | 成都优瑞商务服务有限公司 | A kind of antibacterial medical gloves and preparation method thereof |
| CN108484443A (en) * | 2018-04-11 | 2018-09-04 | 华南农业大学 | A kind of cyanogen flutolanil compound and its preparation method and application with antibacterial activity |
-
2018
- 2018-11-02 CN CN201811300351.9A patent/CN109330065B/en active Active
- 2018-11-02 CN CN202010186496.1A patent/CN111418934A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102099015A (en) * | 2008-07-18 | 2011-06-15 | 拜奥莫达概念公司 | Articles of manufacture releasing an active ingredient |
| CN105860328A (en) * | 2016-04-21 | 2016-08-17 | 武汉馨雅美纺织品有限公司 | Antifouling and antibacterial tablecloth |
| CN107298826A (en) * | 2017-07-30 | 2017-10-27 | 成都优瑞商务服务有限公司 | A kind of antibacterial medical gloves and preparation method thereof |
| CN108484443A (en) * | 2018-04-11 | 2018-09-04 | 华南农业大学 | A kind of cyanogen flutolanil compound and its preparation method and application with antibacterial activity |
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| CN109330065A (en) | 2019-02-15 |
| CN111418934A (en) | 2020-07-17 |
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