CN109172445A - Whitening maintenance cream - Google Patents

Abstract

The invention discloses a kind of whitening maintenance creams, consist of the following components in percentage by weight: whitening maintenance composition 0.1-1%, emulsifier 0.2-10%, emollient 0.1-10%, moisturizer 2-15%, skin conditioning agent 2-15%, thickener 0.1-3%, chelating agent 0-0.1%, preservative 0.2-0.7%, surplus are deionized water.The whitening maintenance composition is prepared by the raw material of following parts by weight: 0.1-5 parts and scutellariae,radix 0.1-5 parts, 0.1-5 parts of silver wire grass of polygoni cuspidati,radix.The whitening maintenance composition is able to suppress the expression of endothelin -1, weakens the melanin synthesis and deposition final in skin surface；The whitening maintenance composition is added in whitening maintenance cream, skin metabolism can be promoted, moreover it is possible to repair epidermal cell injury and cause parakeratosis, effective active composition penetration therein is extremely superior, can propose feeding nutrition for skin, gives skin ruddy brilliant white.

Description

Whitening maintenance cream

Technical field

The present invention relates to cosmetic fields, more particularly to a kind of whitening maintenance cream.

Background technique

The color of skin be by the quantity of melanocyte synthesis of melanin, type and its around keratinocyte The mode of distribution determines.Melanocyte is the cellule of the mankind, its major function be synthetic dyestuff and formed and It is distributed pigmentation.Melanin is formed by a series of oxidation reactions, the black in tyrosinase catalysis melanocyte 3 different reactions in plain biosynthesis pathway: lower tyrosine is catalyzed at tyrosinase (Tyrosinase, TYR) (Tyrosine, Tyr) is converted to DOPA (DOPA), and DOPA is converted to DOPA quinone (DQ) under the action of tyrosinase.Then, more Bar quinone is converted into dopachrome by autoxidation, ultimately produces 5,6- dihydroxy indole carboxylic acid (DHICA) to form excellent melanocyte. The reaction of the latter is under the catalysis by dopachrome tautomerase (Dopachrometautomerase) and DHICA oxidizing ferment It carries out.Meanwhile under with the catalysis of cysteine or glutathione, DOPA quinone is converted into cysteinyl dopa or gluathione Peptide DOPA, ultimately produces pheomelanin.

Usually said melanin is primarily referred to as excellent melanocyte and pheomelanin.In turn, melanocyte tissue turns melanin It moves on in Epidermal basal layer cells, is brought in cuticula with the metabolism of cell, finally falls off with keratinocyte. Based on human skin structure and melanin forming feature, the approach that modern skin-lightening cosmetic plays effect, which has, inhibits excellent melanocyte and brown The generation and deposition of melanocyte, it is main by inhibiting melanocyte proliferation, inhibit tyrosinase, DOPA in melanin forming process Interconvertible enzyme and DHICA oxidase active.

It is modern mainly to interfere or the formation of blocking part melanin reaches whitening effect.But the generation of melanin The normal physiological reaction of skin, and whitening class product it is common be exactly interference or blocking part melanin formation.It is disturbed Or the harmful substance of many intermediates will be generated in the dermal melanin generating process blocked.So while individual difference, part After people is using some whitening products of this principle, it may occur that the case where skin damage, and a small number of continue user due in skin Increasing for some nuisances enables skin aging accelerate.Therefore, if this kind of whitening product continues use for a long time and goes down to generate not Conducive to the factor of skin health.

Melanosome be in the mammalian body for synthesize with unique organelle of depositing black element, with B16 cell phase The most gene of pass is all located on melanosome, the expression imbalances of these genes or lacks that will to directly affect melanin final Synthesis and deposition.

Melanosome is the specific granule in melanocyte, is made of protein structure and chromolipid, rounded or oval Shape is the organelle for manufacturing melanin.Content of the melanosome in horn cell will will have a direct impact on the color of skin, skin Black human melanoma cell be transferred to the melanosome of horn cell amount it is whiter than skin people it is more.Early in Seglen in 1992 and Bohledy etc. just proposes that some free organelles can be degraded after the content for combining autophagosome release by lysosome/vacuole Fall, and melanosome is degraded caused by mainly this factor, this is also the not agnate diversified reason of skin color. Murase etc. points out that the autophagosome activity of the white human keratinized cell of skin is higher than the black people of skin, and autophagosome is inhibited to reduce melanocyte The degradation of corpusculum can be such that skin color significantly blackens；And autophagosome is activated to increase the degradation of melanosome, skin color will be made It shoals.Also, further investigations have shown that the expression of endothelin -1 (Endothelin-1, ET-1) facilitates melanosome fusion Into horn cell.

It is largely ground conducted in the skin care industry about skin whitening efficacy that the present inventor is previously mentioned After studying carefully work, it was unexpectedly found that: the extract of scutellariae,radix, polygoni cuspidati,radix and silver wire grass is able to suppress the table of endothelin -1 It reaches, and then weakens the melanin synthesis and deposition final in skin surface.

Summary of the invention

To solve the shortcomings and deficiencies of the prior art, the primary purpose of the present invention is that providing a kind of whitening maintenance Cream.

The object of the invention is achieved through the following technical solutions:

A kind of whitening maintenance cream, consists of the following components in percentage by weight: whitening maintenance composition 0.1-1%, emulsifier 0.2- 10%, emollient 0.1-10%, moisturizer 2-15%, skin conditioning agent 2-15%, thickener 0.1-3%, chelating agent 0-0.1%, anti-corrosion Agent 0.2-0.7%, surplus are deionized water.

The whitening maintenance composition, is prepared by the raw material of following parts by weight: 0.1-5 parts of polygoni cuspidati,radix, scutellariae,radix 0.1-5 parts and 0.1-5 parts of silver wire grass.

The present invention also provides the preparation methods of the whitening maintenance composition, the following steps are included:

1) raw material after drying is weighed, is pre-processed, is pulverized and sieved；

2) petroleum ether obtains filter residue to raw material refluxing extraction after pretreatment, filtering；

3) by filter residue ultrasonic wave Assisted Ethanol Soakage extraction, extracting solution is filtered to obtain；

4) extracting solution is concentrated, obtains medicinal extract；

5) medicinal extract is redissolved in water, obtains aqueous solution；By aqueous solution extracting n-butyl alcohol, extract liquor is dissolved in water into 5g/L solution, Then macroporous resin column chromatography is crossed, with 10%, 35%, 70% ethyl alcohol (V/V) gradient elution, recycles 70% ethanol eluate；

6) the direct vacuum freeze drying of eluent is recycled.

In wherein some embodiments, pretreatment described in step 1) is that the bored profit of rice wine of weight of material 1/10 is added, so Fried dry to material shoals yellow or yellowish-brown in postposition frying container；Taking-up smashes it through 40-80 mesh；Material exists before pre-processing It is dry to constant weight in 50 DEG C in drying box.

In some of embodiments, the amount that petroleum ether is added described in step 2 is weight of material after 3-5 times of pretreatment, institute The time for stating refluxing extraction is 1 hour.

In wherein some embodiments, ethyl alcohol described in step 3) is the ethyl alcohol that percentage by volume is 95%, solid-liquid ratio 1: Soakage extraction 2-4 times under 5-50g/mL, ultrasonic power 80W, each 40min.

In wherein some embodiments, redissolution described in step 5) is that medicinal extract is dissolved in the water of 2-3 times of medicinal extract weight；It is described Extracting n-butyl alcohol is to be extracted with the n-butanol of 3-5 times of medicinal extract aqueous solution weight；The macroporous absorbent resin be JD-1, One of D101, AB-8.

On the one hand pretreatment of the present invention can be played the role of dezymotizing and protect glycosides, be conducive to subsequent glycoside substance and dissolve out, separately On the one hand a part of volatile oil can be removed, irritation is reduced；Removal chlorophyll is extracted through petroleum ether after pretreatment, it can be advantageous In subsequent extracted and Column chromatography；After Column chromatography, it is conducive to inventors have surprisingly discovered that being rich in 70% ethyl alcohol (V/V) eluent The methods of glycosides that skin absorbs, and this constituents is able to suppress the expression of endothelin -1, can weaken melanin skin surface most Whole synthesis and deposition.

In wherein some embodiments, the emulsifier is C14-22 alcohol, C12-20 alkyl glucoside, cetostearyl alcohol Olive oleate, polysorbate -20, glyceryl oleate, stearine, PEG-100 stearate, pentaerythrite two One of stearate is a variety of.

In wherein some embodiments, the emollient is isononyl isononanoate, cetyl dimethicone, poly- two One of methylsiloxane, Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit rouge, polyisobutene, ethylhexyl palmitate Or it is a variety of.

In wherein some embodiments, the moisturizer is glycerol, propylene glycol, Sodium Hyaluronate, hydrolysis silk, methyl-prop One of glycol, PEG/PPG-17/6 copolymer, 1,2- hexylene glycol, pungent glycol, 1,2- pentanediol are a variety of.

In wherein some embodiments, the skin conditioning agent is Margarita extract, Euglena gracilis (EUGLENA GRACILIS) polysaccharide, allantoin, tocopherol acetate, phytosterol Tower rape oil glyceride type, fructose, hydrolysis oat Albumen, rhamnose, glycosylglycerol, Cortex Magnoliae Officinalis (MAGNOLIA OFFICINALIS) bark extract, mandelic acid, ascorbic acid It is (vitamin C), tranexamic acid, beta glucan, glucuronic acid, mannose, niacinamide, arginic one or more.

In wherein some embodiments, the thickener is the hard ester alcohol of spermaceti, polyacrylate -13, carbomer, xanthan gum Mixing.

In wherein some embodiments, the chelating agent is EDTA disodium.

In wherein some embodiments, the preservative be parahydroxyacet-ophenone, glycerol caprylate, decoyl hydroximic acid it is mixed It closes.

Whitening maintenance composition of the present invention adds the common matrix of skin care item or carrier, can be made into whitening maintenance lotion, cream The cosmetics such as frost, facial mask.

Further, a kind of whitening maintenance cream, consists of the following components in percentage by weight: whitening maintenance composition 0.1- 1%, cetostearyl alcohol olive oleate 0.1-0.5% hydrolyze avenin 0.1-0.5%, stearine 0.1-0.5%, sweet Oily oleate 0.1-0.5%, spermaceti hard ester alcohol 0.5-1.5%, ethylhexyl palmitate 1-5%, phytosterol Tower rape oil are sweet Grease class 0.1-1%, Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit rouge 0.1-1%, tocopherol acetate 0.01-0.1% are sweet Oily 1-5%, methyl propanediol 1-5%, PEG/PPG-17/6 copolymer 0.1-2%, EDETATE SODIUM 0.01-0.05%, allantoin 0.1- 0.3%, carbomer 0.1-0.3%, xanthan gum 0.05-0.25%, parahydroxyacet-ophenone 0.1-0.3%, -13 0.01- of polyacrylate 0.1%, polyisobutene 0.1-0.3%, polysorbate -20 0.01-0.1%, glycerol caprylate 0.1-0.2%, decoyl hydroximic acid 0.1-0.2%, 1,2- hexylene glycol 0.1-0.5%, propylene glycol 0.1-1%, Euglena gracilis (EUGLENAGRACILIS) polysaccharide 0.1- 0.5%, fructose 0.1-0.5%, rhamnose 0.1-0.5%, glycosylglycerol 0.1-2%, Cortex Magnoliae Officinalis (MAGNOLIAOFFICINALIS) tree Bark extract 0.1-0.5%, mandelic acid 0.1-0.5%, ascorbic acid (vitamin C) 0.1-0.5%, tranexamic acid 0.1-0.5%, β-Portugal Glycan 0.1-0.5%, glucuronic acid 0.1-0.5%, mannose 0.1-0.5%, niacinamide 0.1-0.5%, arginine 0.1-0.3%, water Surplus.

The present invention has the following advantages and effects with respect to the prior art:

The present invention compounds polygoni cuspidati,radix, scutellariae,radix and silver wire grass prescription, and preprocessed, petroleum ether refluxing extraction, filtering, filter residue are used Ultrasonic wave Assisted Ethanol Soakage extraction, filtering, extracting solution concentration, redissolution, extracting n-butyl alcohol, cross macroporous resin column chromatography, elution, Whitening maintenance composition is prepared in vacuum freeze drying, it is demonstrated experimentally that the whitening maintenance composition is able to suppress endothelin -1 Expression, weaken the melanin synthesis and deposition final in skin surface；The whitening maintenance composition is added to whitening maintenance In cream, skin metabolism can be promoted, moreover it is possible to it repairs epidermal cell injury and causes parakeratosis, effective active composition therein Penetration is extremely superior, can propose feeding nutrition for skin, give skin ruddy brilliant white.

Specific embodiment

With reference to embodiment to of the invention for a more detailed description, but embodiments of the present invention are not limited to This can refer to routine techniques progress for not specifically specified technological parameter or condition.

Part material according to the present invention is described as follows:

Silver wire of the present invention grass (Chloranthus japonicus Sieb.) also known as Radix chloranthi japonici, henry chloranthus herb, manyspike chloranthus herb, The Four Heavenly Kings is Chloranthaceae Chloranthus herbaceos perennial, is distributed in the ground such as Shaanxi, Gansu, complete stool hyoscine, silver wire Grass mainly contains the sequiterpenes such as chloranthalactone, chloranthalactone, silver wire grass alcohol, silver wire grass furan alcohol, silver wire grass spiral shell dienol Dimer and monoterpenes chemical component, have clearing damp cold dispelling, promoting blood circulation and stopping pain, dissipate the stasis of blood removing toxic substances and other effects, for treat cough due to wind-cold evil, Situations such as traumatic injury, carbuncle swells boil, women's menostasis.

Polygonum cuspidate of the present invention (Polygonum cuspidatum Sieb.et Zucc.) it is the perennial filling of polygonaceae Polygonum The wooden shape herbaceous plant, is used as medicine with dry rhizome and root.Its mildly bitter flavor, cold nature return liver, gallbladder, lung channel, mainly contain anthracene in polygonum cuspidate Quinones, flavonoids, class, phenols and some monosaccharides compound, there are many pharmacological action, including anti-inflammatory, antiviral, anti- Bacterium, antithrombotic, changes lectin from hemolymph, expansion blood vessel, protects myocardium, anti-oxidant, antitumor, improvement Alzheimer disease Adjust-blood lipid And it prevents AIDS.

Radix scutellariae of the present invention derives from lamiaceae labiatae scutellaria plant radix scutellariae (Scutellaria baicalensis Georgi), it is used as medicine with root, cold in nature, bitter;Return lung, the heart, liver, large intestine channel, principle active component have scutelloside (baicalin), Wogonoside (wogonoside), baicalein (baicalein) and wogonin (wogonin) etc..With antibacterial, it is antiviral, The bioactivity such as anti-inflammatory, anti-oxidant, antitumor, neuroprotection, cardiovascular protection, antihyperglycemic.

Embodiment 1

A kind of whitening maintenance composition, is prepared by the raw material of following parts by weight: 0.1 part of polygoni cuspidati,radix, 5 parts of scutellariae,radix and silver wire 0.1 part of grass.

The preparation method of the whitening maintenance composition, the following steps are included:

1) polygoni cuspidati,radix, scutellariae,radix, silver wire grass is taken, in 50 DEG C of dryings to constant weight, to weigh the raw material of above-mentioned formula ratio in drying box, It is pre-processed: the bored profit of rice wine of raw material weight 1/10 is added, then set fried dry to material in frying container and shoal yellow or Huang Brown, taking-up smash it through 40 meshes；

2) 5 times of raw material powder weight after pre-processing of petroleum ether is added and carries out refluxing extraction, extraction time is 1 hour, then mistake Filter obtains filter residue；

3) ethyl alcohol that percentage by volume is 95% is added into filter residue, configuration solid-liquid ratio is 1:5g/mL, with ultrasonic wave assisted extraction, Soakage extraction 2 times at ultrasonic power 80W, each 40min, filtering, merging filtrate obtain extracting solution；

4) extracting solution is concentrated, obtains medicinal extract；

5) medicinal extract is redissolved in the water of 2 times of medicinal extract weight, obtains aqueous solution, by 5 times of medicinal extract aqueous solution weight of aqueous solution N-butanol is extracted, and extract liquor is dissolved in water into 5g/L solution, then crosses JD-1 macroporous resin column chromatography, successively successively with 10%, 35%, 70% ethyl alcohol (V/V) gradient elution recycles 70% ethanol eluate；

6) the direct vacuum freeze drying of eluent, yield 8.2% are recycled.

Embodiment 2

A kind of whitening maintenance composition, is prepared by the raw material of following parts by weight: 5 parts of polygoni cuspidati,radix, 0.1 part of scutellariae,radix and silver wire 5 parts of grass.

The preparation method of the whitening maintenance composition, the following steps are included:

1) polygoni cuspidati,radix, scutellariae,radix, silver wire grass is taken, in 50 DEG C of dryings to constant weight, to weigh the raw material of above-mentioned formula ratio in drying box, It is pre-processed: the bored profit of rice wine of raw material weight 1/10 is added, then set fried dry to material in frying container and shoal yellow or Huang Brown, taking-up smash it through 80 meshes；

2) 3 times of raw material powder weight after pre-processing of petroleum ether is added and carries out refluxing extraction, extraction time is 1 hour, then mistake Filter obtains filter residue；

3) ethyl alcohol that percentage by volume is 95% is added into filter residue, configuration solid-liquid ratio is 1:50g/mL, is mentioned with ultrasonic wave auxiliary It takes, Soakage extraction 4 times at ultrasonic power 80W, each 40min, filters, merging filtrate obtains extracting solution；

4) extracting solution is concentrated, obtains medicinal extract；

5) medicinal extract is redissolved in the water of 3 times of medicinal extract weight, obtains aqueous solution, by 3 times of medicinal extract aqueous solution weight of aqueous solution N-butanol is extracted, and extract liquor is dissolved in water into 5g/L solution, then crosses D101 macroporous resin column chromatography, successively successively with 10%, 35%, 70% ethyl alcohol (V/V) gradient elution recycles 70% ethanol eluate；

6) the direct vacuum freeze drying of eluent, yield 8.4% are recycled.

Embodiment 3

A kind of whitening maintenance composition, is prepared by the raw material of following parts by weight: 1 part of polygoni cuspidati,radix, 1 part of scutellariae,radix and silver wire grass 1 part.

The preparation method of the whitening maintenance composition, the following steps are included:

1) polygoni cuspidati,radix, scutellariae,radix, silver wire grass is taken, in 50 DEG C of dryings to constant weight, to weigh the raw material of above-mentioned formula ratio in drying box, It is pre-processed: the bored profit of rice wine of raw material weight 1/10 is added, then set fried dry to material in frying container and shoal yellow or Huang Brown, taking-up smash it through 60 meshes；

2) 4 times of raw material powder weight after pre-processing of petroleum ether is added and carries out refluxing extraction, extraction time is 1 hour, then mistake Filter obtains filter residue；

3) ethyl alcohol that percentage by volume is 95% is added into filter residue, configuration solid-liquid ratio is 1:25g/mL, is mentioned with ultrasonic wave auxiliary It takes, Soakage extraction 3 times at ultrasonic power 80W, each 40min, filters, merging filtrate obtains extracting solution；

4) extracting solution is concentrated, obtains medicinal extract；

5) medicinal extract is redissolved in the water of 3 times of medicinal extract weight, obtains aqueous solution, by 4 times of medicinal extract aqueous solution weight of aqueous solution N-butanol is extracted, and extract liquor is dissolved in water into 5g/L solution, then crosses AB-8 macroporous resin column chromatography, successively successively with 10%, 35%, 70% ethyl alcohol (V/V) gradient elution recycles 70% ethanol eluate；

6) the direct vacuum freeze drying of eluent, yield 8.5% are recycled.

1 composition is tested to the inhibiting effect of ET-1

Melanocyte in skin be not it is isolated existing, influenced by surrounding microenvironment, wherein keratinocyte point The cell factor secreted passes through the proliferation, melanocyte the effects of various mechanism such as autocrine, paracrine in melanocyte, to melanocyte The processes such as synthesis and transhipment play crucial adjustment effect.Ultraviolet light includes and as extraneous factor, can promote keratinocyte The cell factors such as synthesis and secretion IL-1a, ET-1, bFGF.Dendron is the important symbol of melanocyte, and melanocyte passes through dendron The melanocyte of synthesis is transported to neighbouring keratinocyte, plays the effect of epidermis melanocyteization, ET-1, which has, promotes dendron to generate Effect.

According to bibliography, (Zuo Fu state Rho-GTPase adjusts human melanocytes and B16 melanoma cells tree for this experiment It is exsule at the Effect study transported with melanocyte [D] Fudan University, 2009.) in the 4th trifle " ELISA method detection angle of first part Matter forms the concentration of IL-1a, ET-1 and bFGF in cell culture supernatant " experimental method, this is added in 311nmUVB irradiation Inventive composition examines then inhibiting effect of the embodiment 1-3 composition to ET-1.

Experimental result:

In the influence experiment of 311nmUVB Human Keratinocytes secretion ET-1, in 25 and 50mJ/cm²When dosage, do not having It adds ET-1 concentration in the contrast groups Human keratinocytes culture supernatant of embodiment 1-3 composition and is added to embodiment 1- The obvious raising of the experimental group of 3 compositions illustrates that embodiment 1-3 composition has the inhibiting effect to ET-1.As a result such as 1 institute of table Show:

Table 1

Test two whitenings test

Composition made from embodiment 1-3 is added in whitening maintenance cream, the whitening maintenance cream 1- formed as shown in table 2 is prepared 3 and comparative example 4-7, is grouped as by the group of following mass percentage:

Table 2

Wherein, the comparative example 1 obtains composition and distinguishes with embodiment 3 and is, comparative example 1 prepares raw material and lacked polygoni cuspidati,radix；It is described Comparative example 2 obtains composition and is that comparative example 2 prepares raw material and lacked scutellariae,radix with the difference of embodiment 3；The comparative example 3 must combine Object is that comparative example 3 prepares raw material and lacked silver wire grass with the difference of embodiment 3.

Wherein the comparative example 4 obtains composition and is prepared by the raw material of following parts by weight: 1 part of polygoni cuspidati,radix, 1 part of scutellariae,radix With 1 part of silver wire grass；The composition preparation method, the following steps are included:

1) polygoni cuspidati,radix, scutellariae,radix, silver wire grass is taken, in 50 DEG C of dryings to constant weight, to weigh the raw material of above-mentioned formula ratio in drying box, Then it crushes, crosses 60 meshes；

2) 4 times of raw material powder weight after pre-processing of petroleum ether is added and carries out refluxing extraction, extraction time is 1 hour, then mistake Filter obtains filter residue；

3) ethyl alcohol that percentage by volume is 95% is added into filter residue, configuration solid-liquid ratio is 1:25g/mL, is mentioned with ultrasonic wave auxiliary It takes, Soakage extraction 3 times at ultrasonic power 80W, each 40min, filters, merging filtrate obtains extracting solution；

4) extracting solution is concentrated, obtains medicinal extract；

5) medicinal extract is redissolved in the water of 3 times of medicinal extract weight, obtains aqueous solution, by 4 times of medicinal extract aqueous solution weight of aqueous solution N-butanol is extracted, and extract liquor is dissolved in water into 5g/L solution, then crosses AB-8 macroporous resin column chromatography, successively successively with 10%, 35%, 70% ethyl alcohol (V/V) gradient elution recycles 70% ethanol eluate；

6) the direct vacuum freeze drying of eluent, yield 4.5% are recycled.

The effect of in order to assess whitening maintenance cream 1-3 and comparative example 4-7 of the present invention, by whitening maintenance cream 1-3 and comparative example Product made from 4-7 is tested with volunteer, distributes sample to 350 age 18-43 years old volunteer (wherein female Property 236), health, rule of life, no skin disease, volunteer is divided into 7 groups at random.After volunteer cleans facial skin, It dries, 2g cleawhite over-night essences is applied on the square Experimental Area of left side one piece of 2cm × 2cm of face with hand, right side face Skin is not smeared, and as cleawhite over-night essences test comparison area, continuous use checks using effect in 30 days, and fills in questionnaire. Every group of 50 people disable other cosmetics or drug during test, be used continuously 4 weeks, and observation uses as a result, as shown in table 3.

Judgment criteria

Be obviously improved: opposite right side face, test block whitening skin degree increase, and the obscure obvious desalination of the colour of skin or are solved, skin It is smooth such as new, ruddy brilliant white.

Invalid: opposite right side face, test block fairness do not increase or increase unobvious, and the obscure nothing of the colour of skin obviously becomes Change or deepens.

Table 3

Conclusion (of pressure testing): experiments have shown that, whitening maintenance cream 1-3 has good whitening effect.

By whitening maintenance cream 1-3 and comparative example 4-6 comparison it is found that polygoni cuspidati,radix, scutellariae,radix and silver wire grass are that increase skin is white Fair-skinned degree improves the obscure key component of the colour of skin, and the whitening maintenance composition that compounding is prepared when sharing is applied in whitening maintenance cream Effect is just significant；The composition prepared when lacking one of ingredient is applied in whitening maintenance cream, and effect is undesirable.

By whitening maintenance cream 1-3 and the comparison of comparative example 7 it is found that the beauty that polygoni cuspidati,radix, scutellariae,radix and silver wire grass are prepared when sharing White maintenance composition is applied in whitening maintenance cream, whitening effect when lacking the whitening maintenance composition that preprocessing process obtains It is obvious newborn not as good as the whitening maintenance for being added to the whitening maintenance composition obtained by pretreatment, it is seen then that pretreatment is a pass Key step.

It is learnt through inquiry, using whitening maintenance cream 1-3 of the present invention, mild non-stimulated, skin sense is fine, safe and non-toxic.

And the volunteer of 7 sample of comparative example is used, 63% tested volunteer reaction, sample has minimal irritation to skin, Demonstrate pre-process this process can reduce product irritation.

Embodiment described above only describe the preferred embodiments of the invention, not to model of the invention It encloses and is defined, without departing from the spirit of the design of the present invention, those of ordinary skill in the art are to technical side of the invention The various changes and improvements that case is made should all be fallen into the protection scope that claims of the present invention determines.

Claims (8)

1. a kind of whitening maintenance cream, which is characterized in that consist of the following components in percentage by weight: whitening maintenance composition 0.1- 1%, emulsifier 0.2-10%, emollient 0.1-10%, moisturizer 2-15%, skin conditioning agent 2-15%, thickener 0.1-3%, chelating Agent 0-0.1%, preservative 0.2-0.7%, surplus are deionized water.

2. whitening maintenance cream according to claim 1, which is characterized in that the whitening maintenance composition, by following weight The raw material of part is prepared: 0.1-5 parts of polygoni cuspidati,radix, 0.1-5 parts of scutellariae,radix and 0.1-5 parts of silver wire grass.

3. whitening maintenance cream according to claim 2, which is characterized in that the preparation method of the whitening maintenance composition, The following steps are included:

(1) raw material after drying is weighed, is pre-processed, is pulverized and sieved；

(2) petroleum ether obtains filter residue to raw material refluxing extraction after pretreatment, filtering；

(3) by filter residue ultrasonic wave Assisted Ethanol Soakage extraction, extracting solution is filtered to obtain；

(4) extracting solution is concentrated, obtains medicinal extract；

(5) medicinal extract is redissolved in water, obtains aqueous solution；By aqueous solution extracting n-butyl alcohol, extract liquor is dissolved in water into 5g/L solution, Then macroporous resin column chromatography is crossed, with 10%, 35%, 70% ethyl alcohol (V/V) gradient elution, recycles 70% ethanol eluate；

Recycle the direct vacuum freeze drying of eluent.

4. whitening maintenance cream according to claim 3, which is characterized in that pretreatment described in step 1) is addition material weight Then the bored profit of rice wine of amount 1/10 sets fried dry to material in frying container and shoals yellow or yellowish-brown；Taking-up smashes it through 40-80 Mesh；Material is dry to constant weight in 50 DEG C in drying box before pre-processing.

5. whitening maintenance cream according to claim 3, which is characterized in that the amount that petroleum ether is added described in step 2 is 3- Weight of material after 5 times of pretreatments, the time of the refluxing extraction are 1 hour.

6. whitening maintenance cream according to claim 3, which is characterized in that ethyl alcohol described in step 3) is that percentage by volume is 95% ethyl alcohol, Soakage extraction 2-4 times under solid-liquid ratio 1:5-50g/mL, ultrasonic power 80W, each 40min.

7. whitening maintenance cream according to claim 3, which is characterized in that redissolution described in step 5) is that medicinal extract is dissolved in 2-3 In the water of times medicinal extract weight；The extracting n-butyl alcohol is to be extracted with the n-butanol of 3-5 times of medicinal extract aqueous solution weight；It is described big Macroporous adsorbent resin is one of JD-1, D101, AB-8.

8. whitening maintenance cream according to claim 1, which is characterized in that the component including following mass percentage: beauty White maintenance composition 0.1-1%, cetostearyl alcohol olive oleate 0.1-0.5% hydrolyze avenin 0.1-0.5%, glyceryl stearate Acid esters 0.1-0.5%, glyceryl oleate 0.1-0.5%, spermaceti hard ester alcohol 0.5-1.5%, ethylhexyl palmitate 1-5%, plant steroid Alcohol Tower rape oil glyceride type 0.1-1%, Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit rouge 0.1-1%, tocopherol second Acid esters 0.01-0.1%, glycerol 1-5%, methyl propanediol 1-5%, PEG/PPG-17/6 copolymer 0.1-2%, EDETATE SODIUM 0.01- 0.05%, allantoin 0.1-0.3%, carbomer 0.1-0.3%, xanthan gum 0.05-0.25%, parahydroxyacet-ophenone 0.1-0.3% gather Acrylate -13 0.01-0.1%, polyisobutene 0.1-0.3%, polysorbate -20 0.01-0.1%, glycerol caprylate 0.1- 0.2%, decoyl hydroximic acid 0.1-0.2%, 1,2- hexylene glycol 0.1-0.5%, propylene glycol 0.1-1%, Euglena gracilis (EUGLENAGRACILIS) polysaccharide 0.1-0.5%, fructose 0.1-0.5%, rhamnose 0.1-0.5%, glycosylglycerol 0.1-2% are thick Piao (MAGNOLIAOFFICINALIS) bark extract 0.1-0.5%, mandelic acid 0.1-0.5%, ascorbic acid (vitamin C) 0.1-0.5%, tranexamic acid 0.1-0.5%, beta glucan 0.1-0.5%, glucuronic acid 0.1-0.5%, mannose 0.1-0.5%, nicotinoyl Amine 0.1-0.5%, arginine 0.1-0.3%, surplus are deionized water.