CN109171660A - Photoacoustic imaging probe and application - Google Patents
Photoacoustic imaging probe and application Download PDFInfo
- Publication number
- CN109171660A CN109171660A CN201811174220.0A CN201811174220A CN109171660A CN 109171660 A CN109171660 A CN 109171660A CN 201811174220 A CN201811174220 A CN 201811174220A CN 109171660 A CN109171660 A CN 109171660A
- Authority
- CN
- China
- Prior art keywords
- reflecting surface
- photoacoustic imaging
- light
- module
- reflecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4416—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
The present invention provides a kind of photoacoustic imaging probe and applications, are related to technical field of photoacoustic.Photoacoustic imaging probe includes optical fiber, light beam shaping module, light reflecting module and ultrasonic probe, wherein, light reflecting module includes the first reflecting surface and the second reflecting surface, second reflecting surface is reflective film, it is using specific polydimethyl siloxane material as base layer, and the reflective coating of complex matrix layer surface collectively forms the plane of the high ultrasonic transmittance of high optical reflectance, this design can effectively reduce reduction ultrasonic losses, obtain the photoacoustic image of more high s/n ratio, improve in traditional bright field illumination design be easy to cause ultrasonic losses larger using PMMA coupling module, the lower technical problem of signal noise ratio (snr) of image.The present invention also provides application of the above-mentioned photoacoustic imaging probe in photoacoustic imaging.
Description
Technical field
The present invention relates to technical field of photoacoustic, pop one's head in and apply more particularly, to a kind of photoacoustic imaging.
Background technique
Fusion based on ultrasonic imaging and optical image technology, a kind of emerging imaging skill developed rapidly in recent years
Art-photoacoustic imaging brings a field technology to reform to medical imaging field.Photoacoustic imaging passes through detection tissue resorption pulse
The advantages of having both optics and ultrasonic imaging: ultrasound (optoacoustic) image formation generated after laser not only has very high optical imagery
Contrast and sensitivity, and have the unique high-resolution imaging ability that may span across the multiple scales of molecule, tissue, organ.Light
Acoustic imaging technology has been demonstrated to be suitable for the cancers early detections, tumor grade such as guidance sentinel lymph node biopsy, liver cancer, breast cancer
A series of and biomedical applications such as edge detection, intravascular vulnerable plaque detection.
Hand-held optoacoustic system is usually and directly carries out on the basis of the hand-held probe of existing supersonic imaging apparatus at present
Optical coupling is excited, carries out hand-held real-time optoacoustic cross-sectional imaging, while realizing the real time fusion of photoacoustic image and ultrasound image.It should
The advantages of scheme, is to can make full use of the handiness of ultrasonic hand-held probe, compared to traditional acousto-optic imaging method, this
Kind design is more advantageous to the clinical conversion of photoacoustic technique.However the Major Difficulties of this design are, are not dramatically increasing ultrasound
In the case where probe size, how exciting light is succinctly efficiently transmitted to target tissue site, obtains the optoacoustic figure of high quality
Picture.Currently, in the photoacoustic imaging system based on ultrasonic hand-held linear transducer array, according to the coupled modes of exciting light and ultrasonic probe
Difference, there are mainly two types of design scheme:
The first design can be referred to as dark-ground illumination design, specific as shown in Figure 1.Light source outgoing is optically coupled into optical fiber
In beam 10, the other end of fiber optic bundle 10 is branched into the two sides that ultrasonic probe 4 is respectively fixed to after two parts, and exciting light is from two sides
Oblique to be mapped on object 5 to be measured, the certain depth in the underface of ultrasonic probe 4 converges.But the shortcomings that dark-ground illumination designs
It is, the irradiation area of light is overlapped to be not enough with the search coverage of ultrasonic probe 4, i.e. the signal that detects of ultrasonic probe 4
The mainly signal in region that focuses within the organization of light, and in the energy of other search coverage (near field and far-field region) light
It is too weak and be difficult to inspire stronger photoacoustic signal.The utilization rate of light is relatively low in dark-ground illumination design, optoacoustic letter obtained
Number signal-to-noise ratio it is weaker.
For improve light utilization rate, therefore occur second of design scheme, can be described as bright field illumination design, specifically such as Fig. 2 institute
Show.Laser emission is optically coupled into optical fiber 1, and the light being emitted from optical fiber 1 is incident on polymethylacrylic acid by lens group 20
It in methyl esters (abbreviation PMMA) coupling module 30, is finally incident on inside test serum, the photoacoustic signal generated in test serum is again
Through PMMA coupling module 30, detected by ultrasonic probe 4.Although the design of the bright field illumination increases on light utilization efficiency,
And then the signal-to-noise ratio of photoacoustic image has obtained certain promotion, but still remains following disadvantage: the light being emitted from optical fiber 1, saturating
After microscope group 20 and PMMA coupling module 30, light energy has biggish loss, the optoacoustic figure for making it be difficult to obtain high s/n ratio
Picture；The photoacoustic signal generated in test serum will could be detected after PMMA coupling module 30 by ultrasonic probe 4, verified,
The loss of signal reaches 55%, this influences last signal noise ratio (snr) of image very big.
In view of this, the present invention is specifically proposed at least one of to solve the above technical problems.
Summary of the invention
The first object of the present invention is to provide a kind of photoacoustic imaging probe, by using the superb sound transmission of high optical reflectance
Second reflecting surface of the reflective film of rate as light reflecting module can effectively reduce ultrasonic losses, obtain more high s/n ratio
Photoacoustic image.
The second object of the present invention is to provide a kind of application in optical imagery of photoacoustic imaging probe.
In order to solve the above technical problems, spy of the present invention adopts the following technical scheme that
A kind of photoacoustic imaging probe provided by the invention, including optical fiber, light beam shaping module, light reflecting module and ultrasound are visited
Head, the optical fiber and light beam shaping module are located at the side of the ultrasonic probe and parallel with ultrasonic probe, the light reflection
Module is located at the ultrasonic probe close to the side of object to be measured；
The smooth reflecting module includes the first reflecting surface and the second reflecting surface, and it is whole that first reflecting surface is located at the light beam
The side of shape module light direction, second reflecting surface are located at the side of the ultrasonic probe detection direction, and described second is anti-
Penetrating face is reflective film, and including base layer and the reflective coating that matrix layer surface is arranged in, the base layer is by poly dimethyl silicon
Oxygen alkane material is made；
Object to be measured successively is irradiated in by the light beam shaping module, light reflecting module from the light of the fiber exit
On, photoacoustic signal is inspired, photoacoustic signal is transferred into the smooth reflecting module, and the ultrasonic probe receives photoacoustic signal.
Further, first reflecting surface and the second reflecting surface be parallel and interval setting；
The inclined-plane of first reflecting surface and the inclined-plane of the second reflecting surface are in 45° angle with subject surface to be measured.
Further, the center of the optical fiber is aligned with the center line of first reflecting surface, in the ultrasonic probe
Heart line is aligned with the center line of second reflecting surface；
It is visited to the ultrasound at the center of horizontal space and the optical fiber between first reflecting surface and the second reflecting surface
The horizontal space of the center line of head is equal.
Further, the reflective coating is silver film, and the silver film is plated in the surface of the base layer.
Further, the smooth reflecting module includes frame, and first reflecting surface and the second reflecting surface are both secured to institute
It states on frame.
Further, first reflecting surface is reflecting optics.
Further, the optical fiber is single multimode fiber.
Further, the light beam shaping module includes plano-concave lens and plano-convex lens, the plano-concave lens peace convex lens
The setting of mirror interval, and the primary optical axis of the primary optical axis of the plano-concave lens and the plano-convex lens is in 90 ° of angles.
Further, the light of the fiber exit forms rectangular light spot after the light beam shaping module.
The present invention also provides a kind of application of photoacoustic imaging probe in photoacoustic imaging.
Compared with prior art, photoacoustic imaging probe provided by the invention has the following beneficial effects:
(1) photoacoustic imaging probe provided by the invention, including optical fiber, light beam shaping module, light reflecting module and ultrasound are visited
Head, wherein light reflecting module includes the first reflecting surface and the second reflecting surface, and it is using specific that the second reflecting surface, which is reflective film,
Polydimethyl siloxane material as base layer, and the reflective coating of complex matrix layer surface collectively forms high optical reflectance height
The plane of ultrasonic transmittance, this design can effectively reduce ultrasonic losses, obtain the photoacoustic image of more high s/n ratio, improve biography
Using PMMA coupling module to be easy to cause in system bright field illumination design, ultrasonic losses are larger, the lower technology of signal noise ratio (snr) of image is asked
Topic.
(2) experiments verify that, the ultrasonic losses rate for using the hand-held photoacoustic imaging of PMMA coupling module to pop one's head in is 55%
Left and right, and use the ultrasonic losses rate of photoacoustic imaging provided by the invention probe that can be reduced to 20%, signal noise ratio (snr) of image is opposite to be adopted
10dB is improved with the hand-held photoacoustic imaging probe of PMMA coupling module.
(3) in view of advantage possessed by photoacoustic imaging provided by the invention probe, so as to effectively carry out biology
Institutional framework and functional imaging provide to study morphosis, physiological characteristic, pathological characters, the metabolic function etc. of biological tissue
Important means, particularly suitable for the early detection and treatment monitoring of cancer, in field of photoacoustic imaging especially medical imaging
Field is with a wide range of applications.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is the structural schematic diagram of the first design of the prior art；
Fig. 2 is the structural schematic diagram of second of prior art design；
Fig. 3 is a kind of structural schematic diagram of photoacoustic imaging probe provided by the invention；
Fig. 4 is the top view of smooth reflecting module provided by the invention；
Fig. 5 is the bottom view of smooth reflecting module provided by the invention；
Fig. 6 is the schematic cross-section of smooth reflecting module provided by the invention；
Fig. 7 is the schematic cross-section of the second reflecting surface provided by the invention.
Appended drawing reference:
1- optical fiber；2- light beam shaping module；3- light reflecting module；4- ultrasonic probe；5- object to be measured；10- fiber optic bundle；
20- lens group；30-PMMA coupling module；The first reflecting surface of 31-；The second reflecting surface of 32-；33- frame；321- base layer；322-
Reflective coating.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the orientation or position of the instructions such as term " on ", "lower", " centre "
Relationship is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of description of the present invention and simplification of the description, without referring to
Show or imply that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore cannot manage
Solution is limitation of the present invention.In addition, term " first ", " second " are used for description purposes only, and it should not be understood as instruction or dark
Show relative importance.
According to an aspect of the invention, there is provided a kind of photoacoustic imaging probe, specifically as shown in fig. 3 to 7.The optoacoustic at
As probe, including optical fiber 1, light beam shaping module 2, light reflecting module 3 and ultrasonic probe 4, optical fiber 1 and light beam shaping module 2
In the side of ultrasonic probe 4 and parallel with ultrasonic probe 4, light reflecting module 3 is located at ultrasonic probe 4 close to the one of object 5 to be measured
Side.Wherein, the hatching in Fig. 3 is light portion.
Light reflecting module 3 includes the first reflecting surface 31 and the second reflecting surface 32, and the first reflecting surface 31 is located at beam shaping mould
The side of 2 light direction of block, the second reflecting surface 32 are located at the side of 4 detection direction of ultrasonic probe to guarantee the second reflecting surface 32
Middle line is coaxial with the middle line of ultrasonic probe 4 coplanar, and the second reflecting surface 32 is a reflective film, including base layer 321 and setting exist
The reflective coating 322 on 321 surface of base layer, it is specific as shown in Figure 7.Base layer 321 is by dimethyl silicone polymer
(polydimethyl siloxane, PDMS) material is made.
The light being emitted from optical fiber 1 is successively along 4 side of ultrasonic probe, the direction vertical with 5 surface of object to be measured, by light
Beam Shaping Module 2 becomes the hot spot of specific shape after focusing, enter light reflecting module 3.Enter the light in light reflecting module 3
By the total reflection of the first reflecting surface 31, travels to along the direction parallel with 5 surface of object to be measured and detected positioned at ultrasonic probe 4
On the second reflecting surface 32 on direction, light passes through the total reflection of the second reflecting surface 32, immediately below vertical irradiation to ultrasonic probe 4
4 detection zone of ultrasonic probe of object 5 to be measured, inspires photoacoustic signal, and photoacoustic signal is examined through the ultrasonic probe 4 of object 5 to be measured
It surveys area transmissions and enters light reflecting module 3, ultrasonic probe 4 receives photoacoustic signal.
It should be noted that there is opposite position between optical fiber 1, light beam shaping module 2, light reflecting module 3 and ultrasonic probe 4
Set relationship.Light beam shaping module 2 is located on the light direction of optical fiber 1, and optical fiber 1 and light beam shaping module 2 are respectively positioned on ultrasonic probe 4
Side and parallel with the middle line of ultrasonic probe 4 (or detection direction).Light reflecting module 3 is located at ultrasonic probe 4 close to be measured
The side (or on detection direction of ultrasonic probe 4) of object 5.
When photoacoustic imaging probe is as shown in Figure 3 with the modes of emplacement of object 5 to be measured, light beam shaping module 2 at this time
In the lower section of optical fiber 1, light reflecting module 3 is located at the lower section of ultrasonic probe 4 and the side close to object 5 to be measured.Furthermore,
First reflecting surface 31 is located at the lower section of light beam shaping module 2, and the second reflecting surface 32 is located at the lower section of ultrasonic probe 4.
To guarantee that optical signal reaches coaxial coplanar with ultrasonic signal, to reach preferable detection effect, it is preferable that first
Reflecting surface 31 is located at the underface of light beam shaping module 2, and the second reflecting surface 32 is located at the underface of ultrasonic probe 4.
Specifically, the excitation that light source issues is optically coupled in optical fiber 1.Exciting light can be emitted by nanosecoud pulse laser
It arrives.Since nanosecoud pulse laser has the advantages that optoacoustic high conversion efficiency, beam quality are high, usually as photoacoustic imaging
The driving source of signal is generated in research.
Optical fiber 1 is single multimode fiber, for realizing the conduction of light.
Light beam shaping module 2 is located at the direction of 1 emergent light of optical fiber, and the effect of light beam shaping module 2 is by adjusting light beam
Shape meets the needs of specific application, i.e., the light that optical fiber 1 is emitted enters in light beam shaping module 2, through light beam shaping module 2
Adjustment can become the hot spot of specific shape after focusing.
Light beam shaping module 2 in the present embodiment, including plano-concave lens and plano-convex lens.Light first passes through plano-convex lens,
Afterwards by plano-concave lens.There are certain spacing, and the primary optical axis peace convex lens of plano-concave lens between plano-concave lens and plano-convex lens
The primary optical axis of mirror is in 90 ° of angles.
Light reflecting module 3 includes the first reflecting surface 31 and the second reflecting surface 32, and light is anti-by the first reflecting surface 31 and second
Penetrate being totally reflected into object 5 to be measured of face 32, inspire photoacoustic signal, photoacoustic signal using the second reflecting surface 32, by
Ultrasonic probe 4 receives.Light reflecting module 3 mainly realizes excitation of the light to 5 photoacoustic signal of object to be measured.
In the present embodiment, the first reflecting surface 31 of light reflecting module 3 is reflecting optics.
The second reflecting surface 32 in light reflecting module 3 is reflective film, and the second reflecting surface 32 is using base layer 321 and reflection
Film layer 322 is combined.Wherein, base layer 321 is made of polydimethyl siloxane material.Dimethyl silicone polymer is high score
Sub- organo-silicon compound have optically transparent characteristic.It is prepared as raw material through special process using dimethyl silicone polymer
PDMS film belongs to a kind of high polymer elastic thin polymer film.The PDMS film has permanent elasticity, low Young's modulus, excellent
Gas-premeable, chemical stability, thermal stability, low temperature flexibility (- 60~200 DEG C of holding excellent properties), all-transparent, life
The characteristics such as object compatibility.Polydimethyl siloxane material is formed by base layer 321 to be had less compared to PMMA coupling module
Ultrasonic losses.
Reflective coating 322 is set on 321 surface of base layer, can further improve the reflectivity of the second reflecting surface 32.At this
In embodiment, reflective coating 322 is silver film, and silver film is plated in the surface of base layer 321.The coating process of silver film is using this
The coating process of field routine.
The thickness of base layer 321 and reflective coating 322 has a certain impact for the reflection of light and transmission.In this implementation
Example in, base layer 321 with a thickness of more than ten or tens microns, typical but non-limiting thickness is, for example, 10 μm, 20 μm, 30 μ
M, 40 μm, 50 μm, 60 μm, 70 μm or 80 μm；
Reflective coating 322 with a thickness of more than ten or tens nanometers, typical but non-limiting thickness be, for example, 10nm,
20nm, 30nm, 40nm, 50nm, 60nm, 70nm or 80nm.
Different from the PMMA coupling module that uses in the design of traditional bright field illumination, the present embodiment is by dimethyl silicone polymer material
Expect the base layer 321 being made, it is anti-that bloom is collectively formed by the compound reflective coating 322 that 321 surface of base layer is arranged in
The plane of the high ultrasonic transmittance of rate is penetrated, which can effectively reduce ultrasonic losses, the photoacoustic image of more high s/n ratio is obtained, thus
It improves and be easy to cause that ultrasonic losses are larger, signal noise ratio (snr) of image is lower in the design of traditional bright field illumination using PMMA coupling module
Technical problem.
It is provided by the invention compared with using the hand-held photoacoustic imaging of PMMA coupling module probe by experimental verification
The photoacoustic imaging Probe Ultrasonic Searching proportion of goods damageds are reduced to 20% by 55%, and signal noise ratio (snr) of image improves 10dB.
Compared with dark-ground illumination design, the mode of the present embodiment application bright field illumination, the irradiation area and ultrasonic probe 4 of light
Search coverage can be completely coincident, it can be achieved that without detection blind area.And the utilization rate of light is higher, realizes greatly improving for signal-to-noise ratio.
Positional relationship for the first reflecting surface 31 and the second reflecting surface 32 is also to have particular requirement.In the present embodiment
In, the first reflecting surface 31 and the second reflecting surface 32 are in same level, are arranged in parallel and in a fixed spacing.
The inclined-plane inclination angle of first reflecting surface 31 is identical as the inclined-plane inclination angle of the second reflecting surface 32, with object 5 to be measured
Surface is in 45° angle.The setting of 45° angle is to guarantee light ray parallel in 5 surface of object to be measured or perpendicular to 5 table of object to be measured
It propagates in face.
The water of horizontal space and 4 central axis of optical fiber 1 and ultrasonic probe between first reflecting surface 31 and the second reflecting surface 32
Flat spacing is related.In general, if the horizontal space of 4 central axis of optical fiber 1 and ultrasonic probe is larger, the first reflecting surface 31 and
Horizontal space between two reflectings surface 32 is also larger.In the present embodiment, between the first reflecting surface 31 and the second reflecting surface 32
Horizontal space is equal with the horizontal space of 4 central axis of optical fiber 1 and ultrasonic probe.
Other than the first reflecting surface 31 and the second reflecting surface 32, in the present embodiment, light reflecting module 3 includes frame 33.
First reflecting surface 31 and the second reflecting surface 32 are both secured on frame 33.
The material of frame 33 is not particularly limited, using this field conventional material.In the present embodiment, frame
33 material selection plastic frame.
The concrete shape of frame 33 is not particularly limited, as long as being able to satisfy the first reflecting surface 31 and the second reflecting surface 32
Relatively parallel and interval setting.
In the present embodiment, frame 33 is in similar " mouth " character form structure, the first reflecting surface 31 and the second reflecting surface 32 difference
It is oppositely arranged on the two sides of frame 33.
In order to realize the fixation of frame 33, several mounting portions are additionally provided on frame 33.Mounting portion can be this technology neck
The conventional structure in domain, for example, lifting lug etc..
According to another aspect of the present invention, the present invention also provides above-mentioned photoacoustic imaging probe answering in photoacoustic imaging
With.
In view of advantage possessed by above-mentioned photoacoustic imaging probe, so as to effectively carry out mechanics of biological tissue and function
It can be imaged, provide important means to study morphosis, physiological characteristic, pathological characters, the metabolic function etc. of biological tissue,
Particularly suitable for the early detection and treatment monitoring of cancer, have in field of photoacoustic imaging especially medical imaging field extensive
Application prospect.
Finally, it should be noted that above each embodiment is merely illustrative of the technical solution of the present invention, rather than its limitations；
Although referring to aforementioned each embodiment, invention is explained in detail, those skilled in the art should understand that:
It can still modify to technical solution documented by aforementioned each embodiment, or to some or all of technologies
Feature is equivalently replaced；And these are modified or replaceed, the present invention that it does not separate the essence of the corresponding technical solution is each to be implemented
The range of mode technical solution.
Claims (10)
1. a kind of photoacoustic imaging probe, which is characterized in that including optical fiber, light beam shaping module, light reflecting module and ultrasonic probe,
The optical fiber and light beam shaping module are located at the side of the ultrasonic probe and parallel with ultrasonic probe, the smooth reflecting module
Positioned at the ultrasonic probe close to the side of object to be measured；
The smooth reflecting module includes the first reflecting surface and the second reflecting surface, and first reflecting surface is located at the beam shaping mould
The side of block light direction, second reflecting surface are located at the side of the ultrasonic probe detection direction, second reflecting surface
For reflective film, including base layer and the reflective coating that matrix layer surface is arranged in, the base layer is by dimethyl silicone polymer
Material is made；
It is successively irradiated on object to be measured, swashs by the light beam shaping module, light reflecting module from the light of the fiber exit
Photoacoustic signal is issued, photoacoustic signal is transferred into the smooth reflecting module, and the ultrasonic probe receives photoacoustic signal.
2. photoacoustic imaging probe according to claim 1, which is characterized in that first reflecting surface and the second reflecting surface are flat
Row and interval setting；
The inclined-plane of first reflecting surface and the inclined-plane of the second reflecting surface are in the angle 45o with the surface of object to be measured.
3. photoacoustic imaging probe according to claim 1, which is characterized in that the center of the optical fiber and first reflection
The center line in face is aligned, and the center line of the ultrasonic probe is aligned with the center line of second reflecting surface；
The center of horizontal space between first reflecting surface and the second reflecting surface and the optical fiber is to the ultrasonic probe
The horizontal space of center line is equal.
4. photoacoustic imaging probe according to claim 1 to 3, which is characterized in that the reflective coating is silverskin
Layer, the silver film are plated in the surface of the base layer.
5. photoacoustic imaging probe according to claim 1 to 3, which is characterized in that the smooth reflecting module includes
Frame, first reflecting surface and the second reflecting surface are both secured on the frame.
6. photoacoustic imaging probe according to claim 1 to 3, which is characterized in that first reflecting surface is anti-
Penetrate eyeglass.
7. photoacoustic imaging probe according to claim 1 to 3, which is characterized in that the optical fiber is single multimode
Optical fiber.
8. photoacoustic imaging probe according to claim 1 to 3, which is characterized in that the light beam shaping module packet
Include plano-concave lens and plano-convex lens, the plano-concave lens and the setting of plano-convex lens interval, and the primary optical axis of the plano-concave lens and
The primary optical axis of the plano-convex lens is in 90 ° of angles.
9. photoacoustic imaging probe according to claim 1 to 3, which is characterized in that the light of the fiber exit passes through
After crossing the light beam shaping module, rectangular light spot is formed.
The application in photoacoustic imaging 10. photoacoustic imaging described in any one of claim 1-9 is popped one's head in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811174220.0A CN109171660A (en) | 2018-10-09 | 2018-10-09 | Photoacoustic imaging probe and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811174220.0A CN109171660A (en) | 2018-10-09 | 2018-10-09 | Photoacoustic imaging probe and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109171660A true CN109171660A (en) | 2019-01-11 |
Family
ID=64947612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811174220.0A Pending CN109171660A (en) | 2018-10-09 | 2018-10-09 | Photoacoustic imaging probe and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109171660A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102738383A (en) * | 2011-04-14 | 2012-10-17 | 佳能株式会社 | Electromechanical transducer and photoacoustic apparatus |
| US20130261425A1 (en) * | 2012-03-31 | 2013-10-03 | Canon Kabushiki Kaisha | Probe and object information acquisition apparatus using the same |
| CN103720487A (en) * | 2012-10-12 | 2014-04-16 | 佳能株式会社 | Probe, object information acquisition apparatus, and method of manufacturing the probe |
| CN204306791U (en) * | 2014-10-21 | 2015-05-06 | 白晓苓 | A kind of endoscopic imaging probe |
| CN105343903A (en) * | 2015-11-30 | 2016-02-24 | 中国科学院深圳先进技术研究院 | Silicon dioxide-coated prussian blue analogue nano-particles and preparation method and application thereof |
| CN106691390A (en) * | 2017-01-22 | 2017-05-24 | 中国科学院深圳先进技术研究院 | Photoacoustic probe and photoacoustic imaging system |
| CN106971708A (en) * | 2017-02-27 | 2017-07-21 | 电子科技大学 | A kind of poly-lens for being used to amplify ultrasonic detector deflection |
| CN107007256A (en) * | 2017-02-28 | 2017-08-04 | 中国科学院深圳先进技术研究院 | Photoacoustic imaging fixture and its opto-acoustic imaging devices of application |
| CN107474267A (en) * | 2017-07-24 | 2017-12-15 | 华中科技大学 | A kind of photic ultrasonic membrane and preparation method thereof |
-
2018
- 2018-10-09 CN CN201811174220.0A patent/CN109171660A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102738383A (en) * | 2011-04-14 | 2012-10-17 | 佳能株式会社 | Electromechanical transducer and photoacoustic apparatus |
| US20130261425A1 (en) * | 2012-03-31 | 2013-10-03 | Canon Kabushiki Kaisha | Probe and object information acquisition apparatus using the same |
| CN103720487A (en) * | 2012-10-12 | 2014-04-16 | 佳能株式会社 | Probe, object information acquisition apparatus, and method of manufacturing the probe |
| CN204306791U (en) * | 2014-10-21 | 2015-05-06 | 白晓苓 | A kind of endoscopic imaging probe |
| CN105343903A (en) * | 2015-11-30 | 2016-02-24 | 中国科学院深圳先进技术研究院 | Silicon dioxide-coated prussian blue analogue nano-particles and preparation method and application thereof |
| CN106691390A (en) * | 2017-01-22 | 2017-05-24 | 中国科学院深圳先进技术研究院 | Photoacoustic probe and photoacoustic imaging system |
| CN106971708A (en) * | 2017-02-27 | 2017-07-21 | 电子科技大学 | A kind of poly-lens for being used to amplify ultrasonic detector deflection |
| CN107007256A (en) * | 2017-02-28 | 2017-08-04 | 中国科学院深圳先进技术研究院 | Photoacoustic imaging fixture and its opto-acoustic imaging devices of application |
| CN107474267A (en) * | 2017-07-24 | 2017-12-15 | 华中科技大学 | A kind of photic ultrasonic membrane and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| KYUNGJIN等: ""Handheld Photoacoustic Microscopy Probe"", 《SCIENTIFIC REPORTS》 * |
| MUCONG等: ""Linear array-based real-time photoacoustic imaging system with a compact coaxial excitation handheld probe for noninvasive sentinel lymph node mapping"", 《BIOMEDICAL OPTICS EXPRESS》 * |
| YUANYUAN等: ""Compact and low-cost handheld quasibright-field linear-array probe design in photoacoustic computed tomography"", 《J.OF BIOMEDICAL OPTICS》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10165948B2 (en) | Ultrasonic probe and inspection apparatus equipped with the ultrasonic probe | |
| JP5546111B2 (en) | Ultrasonic probe and inspection apparatus provided with the ultrasonic probe | |
| US11530979B2 (en) | Multifocal photoacoustic microscopy through an ergodic relay | |
| Lin et al. | In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography | |
| CN209285474U (en) | Photoacoustic imaging probe and photoacoustic imaging system | |
| JP2015006434A (en) | Information acquisition device | |
| CN103961065A (en) | Biological tissue opto-acoustic confocal micro-imaging device and method | |
| CN204306791U (en) | A kind of endoscopic imaging probe | |
| CN102428343A (en) | Optical tomography system with high-speed scanner | |
| EP3244788A1 (en) | Ultrasound probe | |
| CN105595964A (en) | Double-focusing ultrasonic probe and sparse array photoacoustic tomography imaging system | |
| CN104257342A (en) | Endoscopic imaging probe and imaging method with same | |
| US10314491B2 (en) | Optics for apodizing an optical imaging probe beam | |
| CN105167747A (en) | Handheld photoacoustic imaging probe | |
| CN106510644B (en) | Medical optical coherence chromatographic imaging two dimension scan forward probe based on fiber optic bundle | |
| Bai et al. | Compact and low-cost handheld quasibright-field linear-array probe design in photoacoustic computed tomography | |
| CN101032388A (en) | Optical coherence tomography endoscopic imaging system | |
| CN204813815U (en) | Hand -held type photoacoustic imaging probe | |
| CN215181138U (en) | Self-focusing lens for OCT | |
| CN108261179A (en) | Micro-optical is popped one's head in | |
| Chen et al. | Dual-foci fast-scanning photoacoustic microscopy with 3.2-MHz A-line rate | |
| CN209661612U (en) | Three-dimensional line scans micro-optical probe | |
| US8411366B2 (en) | Optical probe and optical system therefor | |
| CN103393407B (en) | Handheld photoacoustic imaging probe | |
| CN109171660A (en) | Photoacoustic imaging probe and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190111 |
|
| RJ01 | Rejection of invention patent application after publication |