CN109170907A - A kind of preparation method of composition containing NMN, application and sports drink - Google Patents

A kind of preparation method of composition containing NMN, application and sports drink Download PDF

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Publication number
CN109170907A
CN109170907A CN201811001016.9A CN201811001016A CN109170907A CN 109170907 A CN109170907 A CN 109170907A CN 201811001016 A CN201811001016 A CN 201811001016A CN 109170907 A CN109170907 A CN 109170907A
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parts
nmn
composition
sports drink
water
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***
刘喜元
张慧
梁倩
李峰
胡欢
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Hongbo Yuan Technology (shenzhen) Ltd Life
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Hongbo Yuan Technology (shenzhen) Ltd Life
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/66—Proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Food Science & Technology (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

The invention discloses the preparation methods of a kind of composition containing NMN, application and sports drink, are related to pharmaceutical technology field.Composition disclosed by the invention containing NMN, in parts by weight, the isoflavones of glycosyl, 1-10 parts of s- Ademetionines, 1-10 parts of γ-aminobutyric acids, 1-10 parts of PPD and 1-10 parts of Rh2 are gone including 1-10 parts of NMN, 1-10 parts of Co-Q10s, 1-10 parts of chondroitin sulfates, 1-10 parts of ursodesoxycholic acid, 1-10 parts.The composition can be used for preparing alleviation and/or reduce the beverage of fatigue.Sports drink of the technical solution of the present invention rich in NMN composition not only meets adaptation movement or the physilogical characteristics of physical exertion crowd in nutritional ingredient and content, it can also be by rapid osmotic absorption, achieve the effect that keep the skin wet, electrolyte and energy, makes to mobilize and quickly regain one's strength.The preparation process of sports drink is simple, mild condition, is suitable for industrialized mass production.

Description

A kind of preparation method of composition containing NMN, application and sports drink
Technical field
The invention belongs to the systems of pharmaceutical technology field more particularly to a kind of composition containing NMN, application and sports drink Preparation Method.
Background technique
On the run, if tired driver, it may appear that following situation: (1) velocity perturbation, such as in maximum speed It is travelled on 100 kilometers/hour of road, it is desirable that driver only controls running speed at 95 kilometers/hour with the mode stepped on the gas.If Driver is tired, and the speed of car can fluctuate above and below fixing speed, and driver is more tired, and running speed fluctuation is more severe；(2) side is moved Position cannot be maintained at road center traveling or left or right, the more tired driving deviation of driver are more severe when driver has been stranded.With Upper two kinds of fatigue driving situations are breakneck.In general, driver is sleepy and tired in order to be resisted by drinking functional beverage.
The main adding ingredient of energy of in energy drink, can refreshing oneself, supplement is artificial caffeine, taurine, VB race etc..But It is the habituation that the energy drink containing artificial caffeine is easy to cause body to caffeine, stimulates gastric mucosa, increases gastric acid point It secretes, is not able to satisfy healthier, more natural pursuit demand of the people to food, beverage etc..
Energy drink is for the beverage of supplying human body energy, vitamin contained therein (generally B family vitamin) and carbon Hydrate (mainly white granulated sugar, sucrose) is converted into energy under interaction, regains one's strength of body, relieves fatigue to drinking person. The beverage of many supplement body energies currently on the market, most of is all the energy drink containing hormone, although can temporarily mend Energy is filled, but has side effect, seriously affects the health of human body.
Current market sales of red ox anti-fatigue beverage, is by caffeine, taurine, lysine, inositol, vitamin B6, vitamin B12, citric acid, sodium benzoate, lemon yellow, famille rose, white granulated sugar and water composition.There is certain antifatigue function Effect, but be not especially effectively for reducing the feeling of fatigue effect for driving to generate for a long time.Therefore, it is necessary to targetedly develop A kind of antifatigue functional beverage to realize the health of safe driving target of energy.
Summary of the invention
Present invention aims at the shortcomings for solving existing composition, provide a kind of antifatigue, safe and healthy movement Beverage.
To solve the above-mentioned problems, the present invention provides the application and the system of sports drink of a kind of composition containing NMN Preparation Method.
Concrete scheme is as follows:
In a first aspect, the present invention proposes that a kind of composition containing NMN, the composition include following parts by weight of component: 1-10 parts of NMN, 1-10 parts of Co-Q10s, 1-10 parts of chondroitin sulfates, 1-10 parts of ursodesoxycholic acid, the 1-10 parts of soybean for removing glycosyl Isoflavones, 1-10 parts of s- Ademetionines, 1-10 parts of γ-aminobutyric acids, 1-10 parts of PPD and 1-10 parts of Rh2.
Its further technical solution are as follows: further include auxiliary material, the auxiliary material includes at least one of following parts by weight of component: 0.01-0.05 parts of sodium chloride, 0.01-0.05 parts of potassium chloride, 0.001-0.005 parts of vitamin B12s, 0.001-0.01 parts of vitamins C, 0.001-0.005 parts of vitamin B6s, 0.02-0.05 parts of taurines, 3-6 parts of honey, 0.005-0.01 parts of magnesium chlorides.
Its further technical solution are as follows: further include auxiliary material, the auxiliary material includes at least five kinds of following parts by weight of component: 0.01-0.05 parts of sodium chloride, 0.01-0.05 parts of potassium chloride, 0.001-0.005 parts of vitamin B12s, 0.001-0.01 parts of vitamins C, 0.001-0.005 parts of vitamin B6s, 0.02-0.05 parts of taurines, 3-6 parts of honey, 0.005-0.01 parts of magnesium chlorides.
The invention also provides the sports drinks described in any of the above-described technical solution containing NMN to alleviate in preparation preparation And/or the application in the beverage of reduction fatigue.
Second aspect, the present invention propose a kind of sports drink of composition containing NMN, including as described in relation to the first aspect Composition.
A kind of method that the present invention also proposes sports drink for preparing the composition containing NMN as described in second aspect, Include the following steps:
S1, by NMN, Co-Q10, chondroitin sulfate, ursodesoxycholic acid, the isoflavones for removing glycosyl, s- adenosine egg ammonia Acid, γ-aminobutyric acid, PPD and Rh2 are separately dried, crush, crossing 30-80 mesh, and weighing mixing in proportion；
S2, the raw material into step S1 are added water and stir and evenly mix, and then heat to 50-60 DEG C of extraction 1-3h, are mixed Object；
S3, the mixture in step S2 is filtered, obtains leaching liquor；
S4, the leaching liquor that step S3 is added in boiling water and auxiliary material are uniformly mixed, and 50-60 DEG C are maintained the temperature at, at homogeneous Reason, degassing sterilize, are canned, obtain the sports drink containing NMN.
Its further technical solution are as follows: the mass ratio of raw material and water in the step S2 is 1:5-10.
Its further technical solution are as follows: the volume ratio of water is added in leaching liquor obtained in the step S3 and step S2 For 1/5-3/5.
Its further technical solution are as follows: after the auxiliary material in the step S4 is dissolved completely with water, add in boiling water, institute The mass ratio for stating auxiliary material and water is 1:0.5-5.
Its further technical solution are as follows: the leaching liquor in the step S4: the volume ratio of boiling water is 1:5-40.
Compared with prior art, the attainable technical effect of present invention institute includes:
The sports drink of composition provided by the invention rich in NMN alcohol plastid not only meets in nutritional ingredient and content suitable Should move or the physilogical characteristics of physical exertion crowd, moreover it is possible to by rapid osmotic absorption, reach keep the skin wet, electrolyte and energy Effect makes mobilization quickly regain one's strength.The present invention can appropriate adjustment sodium chloride, potassium chloride as needed additive amount, make final The stability of product is guaranteed.
In addition, the present invention is specifically matched using specific ingredient, reasonable recipe, compatibility is proper, ingredient selected by the present invention Compatibility is suitable, meets the theory that traditional Chinese medicine and modern medicine combine, easy to use, good absorption effect, no bad and malicious secondary work With according to clinical verification, capable of effectively improving the energy supply of human body in a short time, have in sports drink field and very big push away Wide and application prospect.
The preparation method of sports drink of the present invention containing NMN, step is simple, mild condition, is suitable for industry Change batch production.
Specific embodiment
Be specifically described the contents of the present invention with experiment by the following examples, these embodiments and experiment be intended merely into One step illustrates the contents of the present invention and illustrates that interest field of the invention by these embodiments and does not test described content Limitation.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts Every other embodiment, shall fall within the protection scope of the present invention.
Embodiment 1
The present embodiment provides a kind of compositions containing NMN, in parts by weight, the composition include 1 part of NMN, 3 parts it is auxiliary Enzyme Q10,7 parts of chondroitin sulfates, 5 parts of ursodesoxycholic acid, 10 parts remove the isoflavones of glycosyl, 3 parts of s- Ademetionines, 1 part γ-aminobutyric acid, 6 parts of PPD and 2 part of Rh2.
Composition provided in an embodiment of the present invention containing NMN, wherein the preparation side of NMN (i.e. nicotinamide mononucleotide) Method is using niacinamide, ATP and xylose as raw material, in Nampt, ribose-phosphate pyrophosphokinase, ribose- 5- phosphoric acid isomerase, ribulose -3- phosphoric acid isomerase, Xylulokinase and xylose isomerase catalytic action under occur it is anti- It answers, nicotinamide mononucleotide is made.
Specific step is as follows:
It is added substrate solution into reaction kettle, the substrate solution contains the xylose of ATP, 30mM of 30mM, 20mM MgCl2, 10mM KC1 and 100mM Tris-HCl buffer, adjust pH to 7.5-8.0；Then following catalyzing enzyme: core is added Sugared phosphoric acid pyrophosphokinase 6g/L substrate solution, ribose-5-phosphate isomerase 10g/L substrate solution, ribulose -3- phosphate isomerase Enzyme l lg/L substrate solution, Xylulokinase 10g/L substrate solution, xylose isomerase 10g/L substrate solution；It stirs evenly laggard Row reacts, and persistently stirs (mixing speed 50rpm) in reaction process, controls 35 DEG C of reaction temperature, maintenance pH value is 7.5-8.0.
After above-mentioned reaction carries out 4h, reaction solution is isolated, and reaction solution is sent into another reaction kettle, then to reaction solution The ZnCl of the middle niacinamide that 60mM is added, 30mM2, 100mM Tris-HCl buffer and Nampt 15g/L substrate solution, the reaction was continued after mixing evenly, persistently stirs (mixing speed 50rpm) in reaction process, control reaction temperature Degree is 35 DEG C, and maintenances pH value is 7.5-8.0, then reacts and (contain NMN up to nicotinamide mononucleotide crude product solution after 4h 12mM), using filter, purifying, it is dry after up to nicotinamide mononucleotide finished product.
The present embodiment also proposed the above-mentioned composition containing NMN and alleviate in preparation and/or reduce in the beverage of fatigue Using.
For example, the present embodiment proposes a kind of sports drink of composition containing NMN, the sports drink by walking as follows Rapid preparation:
S1, each component in composition is separately dried, is crushed, crosses 30 meshes, keeping distribution of particle sizes uniform, mobility is more It is good, it weighs and is uniformly mixed in each component ratio；
In S2, the mixture obtained to step S1 plus the water of 5 times of amounts stirs and evenly mixs, and is uniformly mixed at 25 DEG C, so After be warming up to 50 DEG C after extract 1h, obtain the mixture containing NMN.
S3, the mixture in step S2 is filtered, obtains leaching liquor, leaching liquor be in S2 plus the volume of water 2/5；
S4, the leaching liquor and flavoring agent appropriate that step S3 is added in the boiling water of 5 times of volumes of leaching liquor, are uniformly mixed, Maintain the temperature at 50 DEG C, homogenization 2 times, when the finer words of solution, enhance the stablizing effect of solution, to the solution after homogeneous It is de-gassed, sterilizes, is canned, obtaining the sports drink of the composition containing NMN.
In the present embodiment, suitable flavoring agent such as white sugar, honey, edible salt etc., the present invention couple can be added according to mouthfeel This is not specifically limited.
Sports drink provided in this embodiment rich in NMN composition, which not only meets in nutritional ingredient and content, adapts to movement Or the physilogical characteristics of physical exertion crowd, moreover it is possible to by rapid osmotic absorption, achieve the effect that keep the skin wet, electrolyte and energy, Make to mobilize and quickly regain one's strength.
Embodiment 2
The present embodiment provides a kind of compositions containing NMN, in parts by weight, the composition include 5 parts of NMN, 7 parts it is auxiliary Enzyme Q10,1 part of chondroitin sulfate, 9 parts of ursodesoxycholic acid, 1 part remove the isoflavones of glycosyl, 10 parts of s- Ademetionines, 5 parts γ-aminobutyric acid, 10 parts of PPD and 7 part of Rh2；And auxiliary material, auxiliary material include 0.01 part of sodium chloride, 0.01 part of potassium chloride and 0.005 part of vitamin B12.
The present embodiment also proposed the above-mentioned composition containing NMN and alleviate in preparation and/or reduce in the beverage of fatigue Using.
For example, the present embodiment proposes a kind of sports drink of composition containing NMN, the sports drink by walking as follows Rapid preparation:
S1, by NMN, Co-Q10, chondroitin sulfate, ursodesoxycholic acid, the isoflavones for removing glycosyl, s- adenosine egg ammonia Acid, γ-aminobutyric acid, PPD and Rh2 are separately dried, crush, crossing 50 meshes, keep distribution of particle sizes uniform, and mobility is more preferable, And weighing mixing in proportion；
In S2, the mixture obtained to step S1 plus the water of 8 times of amounts stirs and evenly mixs, and is uniformly mixed at 25 DEG C, so After be warming up to 56 DEG C after extract 1.5h, obtain the mixture containing NMN.
S3, the mixture in step S2 is filtered, obtains leaching liquor, leaching liquor be in S2 plus the volume of water 3/5；
S4, the leaching liquor that step S3 is added in the boiling water of 15 times of volumes of leaching liquor, the water measured in advance with 0.5 times dissolve Auxiliary material and flavoring agent appropriate, be uniformly mixed, maintain the temperature at 55 DEG C, homogenization 2 times, when the finer words of solution, increase The stablizing effect of strong solution, is de-gassed the solution after homogeneous, sterilizes, is canned, obtains the movement drink of the composition containing NMN Material.
Embodiment 3
The present embodiment provides a kind of compositions containing NMN, in parts by weight, the composition include 7 parts of NMN, 8 parts it is auxiliary Enzyme Q10,4 parts of chondroitin sulfates, 6 parts of ursodesoxycholic acid, 3 parts remove the isoflavones of glycosyl, 10 parts of s- Ademetionines, 4 parts γ-aminobutyric acid, 1 part of PPD and 10 part of Rh2；And auxiliary material, auxiliary material include 0.05 part of sodium chloride, 0.003 part of vitamin B12, 0.01 part of vitamin C, 0.004 part of vitamin B6,0.05 part of taurine and 0.009 part of magnesium chloride.
The present embodiment also proposed the above-mentioned composition containing NMN and alleviate in preparation and/or reduce in the beverage of fatigue Using.
For example, the present embodiment proposes a kind of sports drink of composition containing NMN, the sports drink by walking as follows Rapid preparation:
S1, by NMN, Co-Q10, chondroitin sulfate, ursodesoxycholic acid, the isoflavones for removing glycosyl, s- adenosine egg ammonia Acid, γ-aminobutyric acid, PPD and Rh2 are separately dried, crush, crossing 40 meshes, keep distribution of particle sizes uniform, and mobility is more preferable, And weighing mixing in proportion；
In S2, the mixture obtained to step S1 plus the water of 10 times of amounts stirs and evenly mixs, and is uniformly mixed at 40 DEG C, so After be warming up to 60 DEG C after extract 2h, obtain the mixture containing NMN.
S3, the mixture in step S2 is filtered, obtains leaching liquor, leaching liquor be in S2 plus the volume of water 1/2；
S4, the leaching liquor that step S3 is added in the boiling water of 40 times of volumes of leaching liquor, the water measured in advance with 5 times have dissolved Auxiliary material and flavoring agent appropriate are uniformly mixed, maintain the temperature at 60 DEG C, homogenization 2 times, when the finer words of solution, enhancing The stablizing effect of solution is de-gassed the solution after homogeneous, sterilizes, is canned, obtains the movement drink of the composition containing NMN Material.
Embodiment 4
The present embodiment provides a kind of compositions containing NMN, and in parts by weight, the composition includes 10 parts of NMN, 10 parts Co-Q10,10 parts of chondroitin sulfates, 1 part of ursodesoxycholic acid, 7 parts remove the isoflavones of glycosyl, 6 parts of s- Ademetionines, 10 Part γ-aminobutyric acid, 3 parts of PPD and 10 part of Rh2；And auxiliary material, auxiliary material include 0.02 part of sodium chloride, 0.03 part of potassium chloride, 0.002 part of vitamin B12,0.005 part of vitamin C, 0.002 part of vitamin B6,0.03 part of taurine and 0.001 part of chlorination Magnesium.
The present embodiment also proposed the above-mentioned composition containing NMN and alleviate in preparation and/or reduce in the beverage of fatigue Using.
For example, the present embodiment proposes a kind of sports drink of composition containing NMN, the sports drink by walking as follows Rapid preparation:
S1, by NMN, Co-Q10, chondroitin sulfate, ursodesoxycholic acid, the isoflavones for removing glycosyl, s- adenosine egg ammonia Acid, γ-aminobutyric acid, PPD and Rh2 are separately dried, crush, crossing 80 meshes, keep distribution of particle sizes uniform, and mobility is more preferable, And weighing mixing in proportion；
In S2, the mixture obtained to step S1 plus the water of 20 times of amounts stirs and evenly mixs, and is uniformly mixed at 40 DEG C, so After be warming up to 54 DEG C after extract 3h, obtain the mixture containing NMN.
S3, the mixture in step S2 is filtered, obtains leaching liquor, leaching liquor be in S2 plus the volume of water 3/10；
S4, the leaching liquor that step S3 is added in the boiling water of 30 times of volumes of leaching liquor, the water measured in advance with 0.8 times dissolve Auxiliary material and flavoring agent appropriate, be uniformly mixed, maintain the temperature at 54 DEG C, homogenization 2 times, when the finer words of solution, increase The stablizing effect of strong solution, is de-gassed the solution after homogeneous, sterilizes, is canned, obtains the movement drink of the composition containing NMN Material.
Embodiment 5
The present embodiment provides a kind of compositions containing NMN, in parts by weight, the composition include 3 parts of NMN, 4 parts it is auxiliary Enzyme Q10,5 parts of chondroitin sulfates, 10 parts of ursodesoxycholic acid, 5 parts remove the isoflavones of glycosyl, 8 parts of s- Ademetionines, 8 parts γ-aminobutyric acid, 7 parts of PPD and 5 part of Rh2；And auxiliary material, auxiliary material include 0.04 part of sodium chloride, 0.05 part of potassium chloride, 0.004 Part vitamin B12,0.008 part of vitamin C, 0.004 part of vitamin B6,0.04 part of taurine and 6 parts of honey.
The present embodiment also proposed the above-mentioned composition containing NMN and alleviate in preparation and/or reduce in the beverage of fatigue Using.
For example, the present embodiment proposes a kind of sports drink of composition containing NMN, the sports drink by walking as follows Rapid preparation:
S1, by NMN, Co-Q10, chondroitin sulfate, ursodesoxycholic acid, the isoflavones for removing glycosyl, s- adenosine egg ammonia Acid, γ-aminobutyric acid, PPD and Rh2 are separately dried, crush, crossing 80 meshes, keep distribution of particle sizes uniform, and mobility is more preferable, And weighing mixing in proportion；
In S2, the mixture obtained to step S1 plus the water of 18 times of amounts stirs and evenly mixs, and is uniformly mixed at 30 DEG C, so After be warming up to 51 DEG C after extract 2.5h, obtain the mixture containing NMN.
S3, the mixture in step S2 is filtered, obtains leaching liquor, leaching liquor be in S2 plus the volume of water 1/5；
S4, the leaching liquor that step S3 is added in the boiling water of 25 times of volumes of leaching liquor, the water measured in advance with 1 times have dissolved Auxiliary material and flavoring agent appropriate are uniformly mixed, maintain the temperature at 51 DEG C, homogenization 2 times, when the finer words of solution, enhancing The stablizing effect of solution is de-gassed the solution after homogeneous, sterilizes, is canned, obtains the movement drink of the composition containing NMN Material.
Experimental example-sports drink Activity determination
(1) zoopery
Choose healthy male Kunming strain mice 150, weight (20 ± 2) g.It at random will growth be normal, is able to swim by weight Experiment mice be divided into 3 groups: the NMN sports drink of experiment I group stomach-filling embodiment 2, the commercially available polypeptide type of 1 stomach-filling of control group move Beverage, 2 stomach-filling physiological saline of control group, gastric infusion after every group 50, laboratory rearing 1 week, dosage press body surface area ratio Conversion equivalent dose is 0.1mL10g-1, one time a day, continuous 21d.During experiment, mouse freely ingests and drinks water.
(2) measurement of mouse growth rate
The weight of an experiment mice is respectively weighed before and after experiment, calculating averagely has a net increase of quality.It the results are shown in Table 1.
Group Quality/g before testing Quality/g at the end of experiment Averagely have a net increase of quality/g
I group 20.71±1.69 35.08±1.09 14.37±1.52
Control group 1 19.58±1.78 34.54±0.60 14.96±1.66
Control group 2 20.41±1.92 35.29±0.97 14.88±1.41
Influence of 1 different disposal of table to mouse growth speed
As shown in Table 1,3 groups of intragastric administration on mice 21d test results show that I group and the mouse of control group 1,2 averagely have a net increase of quality There was no significant difference.Therefore the sports drink containing NMN does not influence the growth and development of mouse body.
(3) sports drink safety detection
During 21d is fed, every ingest, drink water, stool and urine situation in 3 groups of mouse are observed, growth and development, row are observed Whether normal it is, and whether there are poisoning manifestations, after experiment, checks liver, the heart, lung, kidney, jejunum, spleen of each test mice Whether get damaged or lesion for dirty, thymus gland and testis.
The results show that during 21d is fed, the ingesting, drink water of 3 groups of mouse, stool and urine are normal, and growth and development is good, not Observe that evident act changes and poisoning manifestations, dissects mouse to its liver, the heart, lung, kidney, jejunum, spleen, chest when off-test Gland and testis carry out health examination, do not find obvious lesion, groups of animals internal organs are showed no the damaging as caused by tested material and change Become, therefore the sports drink containing NMN composition is safe and non-toxic.
(4) mouse Burden-Swimming Ability of KM is tested
After mouse continuous gavage 21d, last stomach-filling 30min, swimming with a load attached to the body experiment is carried out.It bears a heavy burden at mouse tail 1/3 Quality is the sheet lead of 5% weight, puts into depth of water 30cm, 25-30 DEG C of water temperature of swimming trunk went swimming, and observation and record mouse enter certainly The time that cannot be emerged to submerged 10s after water and (exhaust state in power).It the results are shown in Table 2.
Group Power exhausts swimming required time/min
I group 56.3±2.8
Control group 1 35.1±2.0
Control group 2 30.8±1.8
Influence of sports drink of the table 2 containing NMN to the mice burden swimming time
Swimming with a load attached to the body laboratory is the animal model for evaluating antifatigue effect, and length and the exercise tolerance of swimming time have It closes, the degree of animal movement fatigue can be reacted.In this test, mouse is given after different sports drink feeds, and is compareed Group 1,2 is compared, and the processing of I group can significantly extend the mice burden swimming time, and there are significant differences with control group, therefore, can Know that the sports drink containing NMN has the function of centainly antifatigue.
(5) measurement of mouse biochemical indicator
Swimming power is exhausted rear mouse to pull out from water, the 0.5ml of eye socket blood sampling immediately separates serum, detects blood cream in serum The content of sour (Lac), superoxide dismutase (SOD), malonaldehyde (MDA) and serum urea nitrogen (BUN).
Then experiment mice after blood sampling is put to death immediately.Liver is separated, is blotted after physiological saline rinses with filter paper, accurately Liver 200mg is weighed, with the content of anthrone colorimetry measurement each group mouse hepatic glycogen.The results are shown in Table 3.
Group Lac% Hepatic glycogen (mg) SOD(u/ml) MDA(mmol/ml) BUN(mg/ml)
I group 37.01±1.31 5.51±0.55 23.83±1.41 8.53±0.35 14.50±1.07
Control group 1 43.45±1.58 3.80±0.61 15.51±1.34 9.12±0.63 19.58±1.14
Control group 2 48.73±1.20 2.31±0.25 13.19±1.15 10.91±0.41 20.34±1.22
The measurement result of 3 mouse biochemical indicator of table
As seen from the above table, after to mouse continuous gavage 21d, Serum lactic acid content, the mda content of I group are low, and hepatic glycogen surpasses Superoxide dismutase content is higher, and there are significant differences with control group 1 and control group 2.It is provided by the invention to be combined containing NMN The sports drink of object has good synergistic effect, and each component is used in conjunction with, and produces the effect of synergy.
During exercise, muscle produces a large amount of lactic acid by glycolysis reaction, dissociates hydrogen ion generated by lactic acid Increase the hydrogen ion concentration in muscle, pH value decline, and then cause a series of Biochemical changes, lead to fatigue, reduces lactic acid Generation or accelerate removings of lactic acid that can cause antifatigue effect, malonaldehyde is that the sensitivity of measurement matrix Radical Metabolism refers to Mark, content can levels that objectively reactive matrix generates free radicals.This is the experimental results showed that NMN sports drink can inhibit lipid Peroxidating reduces lactic acid accumulation, the very fast effect for eliminating sports fatigue.Glycogen is most important energy substance in movement, in vivo The level of glycogen is closely related with endurance, and the raising that glycogen is storeed is conducive to the raising and run duration of matrix endurance speed Extend.Superoxide dismutase within the organization can be excessive in removing machine body oxygen radical, body immunity can be improved, enhancing is anti- Oxidability, antioxidant have become a kind of important nourishing tonic for sport.Stomach-filling contains the movement drink of NMN composition in experiment After material, mouse superoxide dismutase content, glycogen content are dramatically increased, to prove the sports drink containing NMN composition Oxidation resistance with enhancing mouse, eliminates the function of sports fatigue.Sports drink mechanism of action containing NMN composition can Can significantly reduce the level of metabolite MDA, BUN by the deposit of hepatic glycogen during increase exhausted movemeat, improve SOD Activity accelerates the removing of free radical, enhances the oxidation resistance of mouse, mitigates the oxidative damage of matrix, to improve the fortune of mouse Kinetic force plays antifatigue effect.
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications It should be regarded as protection scope of the present invention.

Claims (10)

1. a kind of composition containing NMN, which is characterized in that including following parts by weight of component: 1-10 parts of NMN, 1-10 parts of coenzyme Q10,1-10 parts of chondroitin sulfates, 1-10 parts of ursodesoxycholic acid, 1-10 parts remove the isoflavones of glycosyl, 1-10 portions of s- adenosine eggs Propylhomoserin, 1-10 parts of γ-aminobutyric acids, 1-10PPD and 1-10 parts of Rh2.
2. as described in claim 1 containing the composition of NMN, which is characterized in that further include auxiliary material, the auxiliary material includes following At least one of parts by weight of component: 0.01-0.05 parts of sodium chloride, 0.01-0.05 parts of potassium chloride, 0.001-0.005 parts of vitamins B12,0.001-0.01 parts of vitamin Cs, 0.001-0.005 parts of vitamin B6s, 0.02-0.05 parts of taurines, 3-6 parts of honey, 0.005-0.01 parts of magnesium chlorides.
3. as claimed in claim 2 containing the composition of NMN, which is characterized in that the auxiliary material includes following parts by weight of component At least five kinds: 0.01-0.05 part of sodium chloride, 0.01-0.05 parts of potassium chloride, 0.001-0.005 parts of vitamin B12s, 0.001- 0.01 part of vitamin C, 0.001-0.005 parts of vitamin B6s, 0.02-0.05 parts of taurines, 3-6 parts of honey, 0.005-0.01 parts Magnesium chloride.
4. the composition as described in any one of claims 1-3 containing NMN is alleviated in preparation and/or is reduced in the beverage of fatigue Application.
5. a kind of sports drink of the composition containing NMN, which is characterized in that including according to any one of claims 1-4 Composition containing NMN.
6. a kind of method for the sports drink for preparing the composition described in claim 5 containing NMN, which is characterized in that including Following steps:
S1, by NMN, Co-Q10, chondroitin sulfate, ursodesoxycholic acid, the isoflavones for removing glycosyl, s- Ademetionine, γ-aminobutyric acid, PPD and Rh2 are separately dried, crush, crossing 30-80 mesh, and weighing mixing in proportion；
S2, the raw material into step S1 are added water and stir and evenly mix, and then extract 1-3h at 50-60 DEG C, obtain mixture；
S3, the mixture in step S2 is filtered, obtains leaching liquor；
S4, the leaching liquor that step S3 is added in boiling water and flavoring agent, auxiliary material are uniformly mixed, and maintain the temperature at 50-60 DEG C, homogeneous It handles, the solution after homogeneous is de-gassed, sterilizes, is canned, obtains the sports drink of the composition containing NMN.
7. the method for the sports drink of composition of the preparation containing NMN as claimed in claim 6, which is characterized in that the step The mass ratio of raw material and water in rapid S2 is 1:5-10.
8. the method for the sports drink of composition of the preparation containing NMN as claimed in claim 7, which is characterized in that the step The 1/5-3/5 of leaching liquor obtained in rapid S3 and the volume that water is added in step S2.
9. the method for the sports drink of composition of the preparation containing NMN as claimed in claim 8, which is characterized in that the step It after auxiliary material in rapid S4 is dissolved completely with water, adds in boiling water, the mass ratio of the auxiliary material and water is 1:0.5-5.
10. the method for the sports drink of composition of the preparation containing NMN as claimed in claim 9, which is characterized in that the step Leaching liquor in rapid S4: the volume ratio of boiling water is 1:5-40.
CN201811001016.9A 2018-08-30 2018-08-30 A kind of preparation method of composition containing NMN, application and sports drink Withdrawn CN109170907A (en)

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CN112515070A (en) * 2020-11-11 2021-03-19 云南爱尔康生物技术有限公司 Sports beverage containing astaxanthin, taurine, nicotinamide mononucleotide and electrolyte and preparation method thereof
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