CN109125443A - A kind of Chinese medicine composition for treating psoriasis - Google Patents
A kind of Chinese medicine composition for treating psoriasis Download PDFInfo
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- CN109125443A CN109125443A CN201811156835.0A CN201811156835A CN109125443A CN 109125443 A CN109125443 A CN 109125443A CN 201811156835 A CN201811156835 A CN 201811156835A CN 109125443 A CN109125443 A CN 109125443A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/74—Rubiaceae (Madder family)
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The present invention relates to a kind of Chinese medicine composition and its preparation for treating psoriasis, traditional Chinese medicine ingredients contained by the Chinese medicine composition are as follows: garden burnet, Asian puccoon, madder, cortex moutan, the root of Dahurain angelica, the Six-elements Chinese herbal medicine such as licorice；The composition obtains alcohol extracting thing through alcohol extracting, has effects that inhibit mouse psoriasis significantly；Its extract is added corresponding auxiliary material medicinal or used for cosmetic and the formulation products such as hydrogel, emulsion and paste is made.Treatment psoriasis Traditional Chinese medicine compound composition of the invention has good anti-inflammatory activity and treatment psoriasis activity, can be applied to the treatment of psoriasis.
Description
Technical field
The present invention relates to the prevention and treatment fields of a kind of cosmetics and medicine field, especially psoriasis.
Background technique
Psoriasis is commonly called as psoriasis, is a kind of chronic inflammatory skin, and the course of disease is longer, there is tendency easy to recur, some diseases
Example almost cannot be cured all one's life.The disease is fallen ill based on person between twenty and fifty, is affected to the health and mental status of patient.Clinical table
Now with erythema, based on the scales of skin that peel off, whole body can fall ill, and it is relatively conventional to stretch side with scalp, four limbs, mostly aggravate in winter.Vulgaris silver
Bits disease is the most common type, more acute onsets；Typical performance is the erythema that boundary understands, shape size is different, around there is inflammation
Property blush；Slightly infiltration thickens；Surface covers the multilayer silvery white scales of skin that peel off；The scales of skin that peel off be easy to scrape it is de-, it is light red shinny semi-transparent after scraping
Bright film scratches the visible small blutpunkte (Auspitz's sign) of film.Arthropathic psoriasis is also known as psoriasis arthropathica.Silver bits
The joint damage of rheumatoid arthritis sample occurs simultaneously for patient, can be involved the big Minor articulus of whole body, but refer to that (toe) saves with end
Between arthropathy most characteristic；Affected joints congestion and swelling pain, periarticular skin are also often red and swollen；Joint symptoms often with skin disease
Shape aggravates or mitigates, blood rheumatoid factor negative simultaneously.The treatment externally applied drug of psoriasis has:
(1) vitamin D 3 analogs.This class medicine includes Calcipotriol, Tacalcitol etc., is used for psoriasis in plaques curative effect
Preferably.This medicine and glucocorticoid or UVB are used in combination and curative effect can be improved.To having treating bone diseases, calcium metabolism disorder and renal function
Infull patient should be used with caution, in order to avoid cause hypercalcemia.(2) glucocorticoid.External application glucocorticoid is still current treatment silver bits
The common therapy of disease.Potent hormone is preferably used in head and palm foot plantar, and weak effect hormone is suitable for face and wiping portion.General place is common
Ointment and emulsifiable paste.Head must then use solution (propylene glycol) and gelling agent.(3) anthraline.It is usually used in chronic plaque psoriasis.It can match
At ointment, paste and paraffin agent.Typical concentrations be 0.05%~1.0%, since low concentration, according to the tolerance situation of patient by
Gradually improve.(4) Tretinoin.Gel and daily apply 1 or 2 time outside of creme (0.05%~0.1%) have good effect to psoriasis.Because working
It is relatively slow, generally it is used alone not as first-line drug.It can be controlled with glucocorticosteroidsin in combination application, skin lesions such as clobetasol propionates
After continue to be phased out glucocorticoid using tazarotene.Pregnant woman, nursing period and has fertility that women is required to disable in the recent period.(5)
Tar class.Common tar includes that coal tar, pine evaporate oil, pityrol and Pityrol etc., is made into the ointment external application of 5% concentration.
For coal tar for chronic stable psoriasis, scalp psoriasis and volar psoriasis curative effect are preferable.Disable in pregnant woman, pustule type and
Erythrodermic psoriasis.Soluble coal tar can be used for taking a shower, and coal tar shampoo is for washing hair.Coal tar spirit is put on the skin for applying,
It is effective to head curing psoriasis.(6) other externally applied drugs such as immunosuppressor such as tacrolimus, pimecrolimus external curing, envelope
It guarantees to cure and treats intractable Local Psoriasis.0.03% Himalayan period, 5% unguentum acidi salicylici etc..Medium-height grass can also be applied
The Chinese patent drugs for treatment psoriasis such as medicine and compound indigo pill, tripterygium wilfordii, Fufang Danshen Pian.
Some Chinese medicines possess a variety of anti-inflammatory active ingredients, show stronger anti-inflammatory activity in vivo and in vitro, especially in
Medicinal material compound shows the Chinese medicines such as synergistic anti-inflammatory activity such as garden burnet, Asian puccoon, cortex moutan, madder, the root of Dahurain angelica and Radix Glycyrrhizae.Under
It is simply introduced in face of these anti-inflammatory Chinese traditional materials:
Garden burnet (Classification system: Sanguisorba officinalis L.) is that rosaceae burnet perennial herb is planted
Object, spindle is sturdy with, short handle leaflet, aubergine petal, and fruit contains in calyx tube.Alias " yellow pawl is fragrant ", " beautiful letter ", " beautiful fermented soya beans, salted or other wise "
Or " acid is reddish brown " etc..Garden burnet root is used as medicine, cold nature, bitter.Modern medicine study proves: garden burnet have blood-stanching and blood-cooling, it is clearing heat and detoxicating,
It is astringing to arrest diarrhea, anti-inflammatory and inhibit the effect of a variety of pathogenic microorganisms, haematemesis, bloody flux can be treated, wound, eczema, upper digestive tract is burnt and goes out
The diseases such as the big bleeding of blood, canker, hematochezia, metrorrhagia and metrostaxis, Tuberculous purulence ulcer and chronic osteomyelitis.Garden burnet root contain tannin about 17%, three
Terpene saponin 2.5~4.0%.The saponin isolated has: ziyu glycoside I, and pomolic acid, arabinose and grape are generated after hydrolysis
Sugar；Ziyu glycoside II generates pomolic acid and arabinose after hydrolysis；Ground persimmon saponin B, Preliminary Identification are the three of glucuronic acid
Terpene saponin.The effective component that anti-inflammatory effect is stolen on ground is 3, and 3 ', 4-, tri--O- methyl benzoaric acid, mouse ear smears defeated tan
Matter 4mg, the significant auricle swelling for inhibiting croton oil to induce take orally this compound 1g/ (kgd), continuous 4d also effectively inhibition bar
The auricle swelling that soya-bean oil induces.
Asian puccoon alias: gromwell root, radix macrotomiae.It is the herbal medicine that Chinese Pharmacopoeia is included, medicinal source is comfrey Xinjiang
The dry root of Asian puccoon, Asian puccoon or arnebia guttata Bunge.Asian puccoon nature and flavor are sweet, salty, tremble with fear.Converge to heart and liver channels.Have cool blood, invigorate blood circulation, removing toxic substances promoting eruption it
Function.Ether, ethyl alcohol or the water extract of Asian puccoon, the orally or topically medication such as alkannin, Acetylshikonin, can inhibit capillary
Hyperfunction (including by histamine, bromelain, bradykinin and anti-rat serum, rabbit anteserum causer) of vasopermeability,
Also it can inhibit the local edema or formaldehyde that cause animal by carrageenan, anti-rat serum, rabbit anteserum, formaldehyde and thermostimulation etc.
Caused small white mouse peritonitis.And inhibit subcutaneous granuloma induced by implantation of cotton pellets hyperplasia, show the vascular permeability that the phase is oozed out to inflammation Acute
Property it is hyperfunction, exudation and oedema and proliferation period inflammation have antagonism.Excision animal adrenal gland still has anti-inflammatory effect.
Cortex moutan, Chinese medicine name.For ranunculaceae peony dry root skin.It is distributed in Anhui, Sichuan, Gansu, Shaanxi, lake more
The ground such as north, Hunan, Shandong, Guizhou.Its matter is hard and crisp, and frangibility, section is flatter, rose pink, mealiness.Gas fragrance, taste are micro-
It is bitter and puckery.Autumn excavates root, removes radicula, strips root skin, dry.It is raw to use or fry use.Compendium of Material Medica: " nourishing yin and lessening fire, solution
Spot poison, throat, diuresis stasis.Descendant is specially controlling mutually fire with amur cork tree, does not know that the function of the root bark of tree peony more wins.Red colored person's benefit, white flower
Person mends, and people also seldom realizes, and preferably distinguishes it." modern study, contained paeonol and its glucosides constituents in addition have anti-inflammatory effect；
The methanolic extract of cortex moutan has inhibition Platelet；Paeonol has the CNS inhibitions such as calmness, cooling, antipyretic, analgesia, spasmolysis
The effects of effect and antiatherosclerosis, diuresis, antiulcer.
Madder (scientific name: Rubia cordifolia L.): Rubiaceae, the perennial herbaceous stem of Rubia climb up by holding on to rattan wood.Madder property
It trembles with fear into blood system, energy cooling blood and hemostasis, and can stagnation resolvation.The blood trouble that goes out of all blood-heat bleeding can be selected.Cooling and activating blood, dissolving stasis, promoting menstruation.With
In haematemesis, bleeding from five sense organs or subcutaneous tissue, metrostaxis, traumatic hemorrhage, menostasis stasis blocking, arthralgia, tumbling and swelling.Cooling blood and hemostasis, promoting blood circulation: this
Product stop blooding without staying the stasis of blood, are used for heat symptom-complex bleeding, menostasis abdominal pain, traumatic injury.It is stronger with cuttle bone hemostasis power.
The root of Dahurain angelica, root is in cone, long 10~20cm, 2~2.5cm of diameter.Surface taupe brown has the hole skin of transverse projections,
There is the stem trace of recess on top.Matter is hard, section white, mealiness foot, and skin zone gathers brown oil drop.Nature and flavor: warm-natured, acrid flavour, gas fragrance,
Slight bitter；Major function: wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving.For having a headache, having a toothache, nasosinusitis, intestines wind anal fistula, leukorrhea with reddish discharge,
Ulcer sores, pruitus.
Radix Glycyrrhizae (scientific name: Glycyrrhiza uralensis Fisch) alias: state is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet tea root
Son.Pulse family, Glycyrrhiza perennial herb, root is sturdy with rhizomes, is a kind of help Chinese herbal medicine.With anti-inflammatory, antiviral and guarantor
The effects of liver removing toxic substances and enhancing immune function.Due to glycyrrhizic acid have the pharmacological action of glucocorticoid sample and without serious adverse reaction,
Clinic is widely used in treating various acute, chronic hepatitis, bronchitis and AIDS, also has anti-cancer and cancer-preventing, interferon inducers
And the functions such as cell immunomodulator.Glycyrrhizic acid has reducing blood lipid and study of anti-atherogenic effect, prevents atherosclerosis
Formation.Radix Glycyrrhizae is clinical most often applied drug.Clearing heat and detoxicating, the moistening lung to arrest cough of licorice energy, harmonizing various medicinal property；Radix glycyrrhizae preparata energy
It invigorates the spleen and benefits qi.
Chinese patent CN102727826A discloses a kind of Chinese medicinal granule for treating psoriasis and its preparation process, using gold
The Chinese medicines compounds such as honeysuckle flower, the shell of seaear, cortex moutan, folium isatidis, Bi dial, oldenlandia diffusa, glutinous rehmannia and turmeric, using two
Secondary extracting in boiling water method prepares Chinese medical extract, and is prepared into the Chinese medicinal granule with treatment psoriasis in turn, has preferable
The effect for the treatment of psoriasis.Chinese patent CN103655814B discloses a kind of Chinese medicine composition for treating psoriasis and application,
Also have effects that treat psoriasis using the oil extract of the careless composition of Asian puccoon, madder and Radix Glycyrrhizae etc. three.Chinese patent
CN106924378 discloses a kind of prevention or/and treatment chronic cheilitis lipstick, is combined using the grass of Asian puccoon, madder and Radix Glycyrrhizae etc. three
Object prepares Chinese medical extract using secondary extracting in boiling water method, and is prepared into the medicinal lip balm formulation with anti-inflammatory activity in turn.
Have effects that preferably to treat chronic cheilitis.
The a variety of compounds of Chinese medicine are obtained optimum formula by optimal screening by the present invention, are had optimal anti-inflammatory activity and are controlled
Treat psoriasis effect, garden burnet, Asian puccoon, tree peony in the best Chinese medicine composition filtered out according to anti-inflammatory animal and psoriasis model
The compound anti-inflammatory activity of the Six-elements Chinese herbal medicine such as skin, madder, the root of Dahurain angelica and Radix Glycyrrhizae is stronger than single medicinal material anti-inflammatory activity, also than Asian puccoon, madder
The anti-inflammatory activity of grass and the careless compositions of Radix Glycyrrhizae etc. three is strong, embody significant Chinese medicine multicomponent and cooperate with anti-inflammatory advantage, has
The novelty and practicability of medicine compound.
Summary of the invention
The effect of in order to improve Chinese herbal treatment psoriasis in the prior art, advanced optimize prior document report Asian puccoon,
Madder and Radix Glycyrrhizae treatment psoriasis Chinese medicine compound prescription as main component, inventor screen by a large amount of zooperies, it was found that one
The new composition of kind has preferably synergistic effect, can not only propose the anti-inflammatory activity of Chinese medicine composition, additionally it is possible to improve it and control
The effect for the treatment of psoriasis.The Chinese medicine material that the present invention uses is that toxic side effect is small, clinically widely used Chinese medicine, product
Safety is good, can be used for a long time.
The present invention provides a kind of Chinese medicine composition for treating psoriasis, includes following ingredient: garden burnet according to mass percent
10-45%, Asian puccoon 10-45%, madder 5-25%, cortex moutan 5-25%, root of Dahurain angelica 0-20%, Radix Glycyrrhizae 5-25%.
It preferably, include following ingredient: garden burnet 20-40%, Asian puccoon 20-40%, madder 10- according to mass percent
25%, cortex moutan 10-20%, root of Dahurain angelica 0-10%, Radix Glycyrrhizae 10-20%.
It most preferably, include following ingredient: garden burnet 25-30%, Asian puccoon 25-30%, madder 15- according to mass percent
20%, cortex moutan 15-20%, root of Dahurain angelica 0-5%, Radix Glycyrrhizae 15-20%.
The present invention also provides a kind of Chinese medical extract for treating psoriasis, the Chinese medical extract is made with the following method
It is standby: to weigh 1 part of any of the above-described Chinese medicine composition, 10 times of alcohols solvents are added and impregnate 12 hours, it is small to heat 80 DEG C of refluxing extractions 2
When；Filtering, the dregs of a decoction add 10 times of alcohols solvents, and heating and refluxing extraction 2 hours；Filtering, merges secondary alcohol solvent extract, 50 DEG C of water
Slurry is concentrated under reduced pressure under bath to get Chinese medical extract.
The alcohols solvent includes methanol, ethyl alcohol, the small molecules fatty alcohols such as isopropanol, preferred alcohol solvent.
The present invention additionally provides a kind of external application plaster preparations for treating psoriasis, which is characterized in that the emplastrum is by such as
The preparation of lower section method: 1) 1 part of synthetic wax, 3 parts of ceresine, 3 parts of synthetic bees wax are weighed, is closed after 80 DEG C of heating water bath stirring and dissolvings respectively
And A liquid；
2) 0.5 part of BHT, 2.5 parts of lanolin, 2.5 parts of albolene, 80 DEG C of heating water bath stirring and dissolvings are weighed, and are added
A liquid is uniformly mixed, and obtains B liquid
3) 14 parts of Chinese medical extract, the glycerol 2 of 0.5 part of Trivent OCG and previously described treatment psoriasis are weighed
Part, 1 part of essence, 80 DEG C of heating water baths are uniformly mixed, and B liquid is added and is mixed evenly, obtains C solution；
4) C solution is imported in vial or other metal tubes while hot, plaster formulation products is made after cooling.
The present invention also provides a kind of external application aqueogels for treating psoriasis, which is characterized in that the aqueogel
It prepares by the following method: 1) weighing 0.3 part of Acritamer 940, add 4.0 parts of deionized water, stirring is impregnated 6-12 hours, and mixing is equal
It is even, carbomer solution A liquid is made；2) 1.5 parts of 2 parts of Chinese medical extract, the glycerol, anhydrous of previously described treatment psoriasis are weighed
1.5 parts of ethyl alcohol, 60 DEG C of heating water bath stirring and dissolvings, and 1) A liquid is added and is uniformly mixed, obtain B liquid；3) weigh 0.5 part of azone,
0.2 part and 0.5 part of essence of allantoin, stirring at normal temperature is uniformly mixed, and the mixing of B liquid, homogeneous uniform is added, it is molten to obtain hydrogel C
Liquid；4) 0.1 part of triethylamine solution is weighed, C solution is stirred down, triethylamine solution is slowly added dropwise, hydrogel viscosity-adjusting agent is arrived
External application aqueogel is made in 20mps.s.
The Chinese medicine composition and its preparation for the treatment of psoriasis of the present invention can be made as ordinary cosmetics, medicinalization
Cosmetic and Chinese medicine compound prescription external preparation.
Agents useful for same and raw material are commercially available available in the present invention.
Garden burnet of the present invention includes garden burnet root herb, the prepared slices of Chinese crude drugs, garden burnet root powder or its extract；The Asian puccoon
Including Asian puccoon medicinal material, the prepared slices of Chinese crude drugs, lithospermum powder or its extract；The cortex moutan include cortex moutan Chinese medicine, the prepared slices of Chinese crude drugs,
Cortex moutan powder and its extract；The madder is that madder herb includes Chinese medicine, the prepared slices of Chinese crude drugs and extract；The root of Dahurain angelica is
Root of Dahurain angelica root includes root of Dahurain angelica root Chinese medicine, the prepared slices of Chinese crude drugs, root of Dahurain angelica root powder and its extract；The Radix Glycyrrhizae is that licorice includes Radix Glycyrrhizae
Root Chinese medicine, the prepared slices of Chinese crude drugs, licorice powder and its extract.
The positive effect of the present invention is that: the Chinese medicine composition of prevention or treatment treatment psoriasis provided by the invention
Not only rationality designs, and there are also the data of a large amount of zooperies screening, it was demonstrated that six kinds of medicinal material synergistic action effects are good；Not only medicine
Material is nontoxic medicinal material, and safety is good, and formula is also fairly simple, is easy to quality control, it is important to can reach more anti-inflammatory
Effect.
Specific embodiment
The present invention is further illustrated below by embodiment, but therefore invention is not limited in scope of embodiments, under
Experimental method is not specified in the embodiment of face is routine experiment method, is operated according to product manual.
The embodiment for treating the Traditional Chinese medicine compound composition formula of psoriasis:
The prescription of 1 embodiment 3-8 of table
| Embodiment number | Garden burnet | Asian puccoon | Cortex moutan | Madder | The root of Dahurain angelica | Radix Glycyrrhizae | The type of alcohol |
| 3 | 10 | 45 | 5 | 25 | 0 | 15 | Methanol |
| 4 | 20 | 30 | 10 | 15 | 0 | 25 | Ethyl alcohol |
| 5 | 30 | 20 | 20 | 10 | 10 | 10 | Ethyl alcohol |
| 6 | 20 | 30 | 20 | 10 | 10 | 10 | Ethyl alcohol |
| 7 | 45 | 10 | 10 | 5 | 20 | 10 | Propyl alcohol |
| 8 | 45 | 10 | 25 | 5 | 10 | 5 | Methanol |
Embodiment 1:
Chinese medicine composition is disclosed according to Chinese patent CN106924378, weighs 40 grams of Asian puccoon, 20 grams of madder, 20 grams of Radix Glycyrrhizae,
Immersion extracting in boiling water 2 hours of (30 times) of 2400ml water is added；It filters, the dregs of a decoction add 1600ml water extracting in boiling water 2 hours, filter, two
Secondary supernatant merges, and 60 DEG C are concentrated under reduced pressure into density 1.10g/cm3Until to get Chinese herbal compounds extract.
Embodiment 2:
Chinese medicine composition is disclosed according to Chinese patent CN103655814B, weighs 40 grams of Asian puccoon, 20 grams of madder, Radix Glycyrrhizae 20
Gram, 800ml water soybean oil is added and impregnates 12 hours, 80 DEG C of water-baths are extracted 2 hours；It filters, the dregs of a decoction add 400ml soybean oil extract 2
Hour, filtering, the extract that supernatant merges to get Chinese herbal compounds twice.
Embodiment 3:
10 grams of garden burnet, 45 grams of Asian puccoon, 5 grams of cortex moutan, 25 grams of madder, 15 grams of Radix Glycyrrhizae are weighed respectively according to table 1, are added
1000ml (10 times) methanol impregnates 12 hours, heats 80 DEG C and extracts 2 hours；Filtering, the dregs of a decoction add 1000ml (10 times) methanol, heat
It extracts 2 hours；Filtering, merges secondary methanolic extract to get the methanolic extract of Chinese medicine composition；It is depressurized under 50 DEG C of water-baths dense
Slurry is reduced to get Chinese medical extract.
Embodiment 4:
20 grams of garden burnet, 30 grams of Asian puccoon, 10 grams of cortex moutan, 15 grams of madder, the root of Dahurain angelica 0,25 grams of Radix Glycyrrhizae are weighed respectively according to table 1,
1000ml (10 times) ethyl alcohol is added to impregnate 12 hours, heats 80 DEG C and extracts 2 hours；Filtering, the dregs of a decoction add 1000ml (10 times) ethyl alcohol,
Heating extraction 2 hours；Filtering, merges secondary ethanol extract to get the ethanol extract of Chinese medicine composition；Subtract under 50 DEG C of water-baths
Pressure is concentrated into slurry to get Chinese medical extract.
Embodiment 5:
30 grams of garden burnet, 20 grams of Asian puccoon, 20 grams of cortex moutan, 10 grams of madder, 10 grams of the root of Dahurain angelica, Radix Glycyrrhizae 10 are weighed respectively according to table 1
Gram, 1000ml (10 times) ethyl alcohol is added and impregnates 12 hours, heats 80 DEG C and extracts 2 hours；Filtering, the dregs of a decoction add 1000ml (10 times) second
Alcohol, heating extraction 2 hours；Filtering, merges secondary ethanol extract to get the ethanol extract of Chinese medicine composition；50 DEG C of water-baths
Under be concentrated under reduced pressure into slurry to get Chinese medical extract.
Embodiment 6:
20 grams of garden burnet, 30 grams of Asian puccoon, 20 grams of cortex moutan, 10 grams of madder, 10 grams of the root of Dahurain angelica, Radix Glycyrrhizae 10 are weighed respectively according to table 1
Gram, 1000ml (10 times) ethyl alcohol is added and impregnates 12 hours, heats 80 DEG C and extracts 2 hours；Filtering, the dregs of a decoction add 1000ml (10 times) second
Alcohol, heating extraction 2 hours；Filtering, merges secondary ethanol extract to get the ethanol extract of Chinese medicine composition；50 DEG C of water-baths
Under be concentrated under reduced pressure into slurry to get Chinese medical extract.
Embodiment 7
45 grams of garden burnet, 10 grams of Asian puccoon, 10 grams of cortex moutan, 5 grams of madder, the root of Dahurain angelica 20,10 grams of Radix Glycyrrhizae are weighed respectively according to table 1,
1000ml (10 times) ethyl alcohol is added to impregnate 12 hours, heats 80 DEG C and extracts 2 hours；Filtering, the dregs of a decoction add 1000ml (10 times) ethyl alcohol,
Heating extraction 2 hours；Filtering, merges secondary ethanol extract to get the ethanol extract of Chinese medicine composition；Subtract under 50 DEG C of water-baths
Pressure is concentrated into slurry to get Chinese medical extract.
Embodiment 8
45 grams of garden burnet, 10 grams of Asian puccoon, 25 grams of cortex moutan, 5 grams of madder, the root of Dahurain angelica 10,5 grams of Radix Glycyrrhizae are weighed respectively according to table 1, are added
Enter 1000ml (10 times) ethyl alcohol to impregnate 12 hours, heats 80 DEG C and extract 2 hours；Filtering, the dregs of a decoction add 1000ml (10 times) ethyl alcohol, add
Thermal extraction 2 hours；Filtering, merges secondary ethanol extract to get the ethanol extract of Chinese medicine composition；It is depressurized under 50 DEG C of water-baths
Slurry is concentrated into get Chinese medical extract.
Embodiment 9: the preparation of emplastrum
1 part of synthetic wax, 3 parts of ceresine, 3 parts of synthetic bees wax are weighed, merges after 80 DEG C of heating water bath stirring and dissolvings respectively, obtains
A liquid；0.5 part of BHT (2,6-di-tert-butyl p-cresol), 2.5 parts of lanolin, 2.5 parts of albolene are weighed, 80 DEG C of heating water baths stir
Dissolution is mixed, and A liquid is added and is uniformly mixed, obtains B liquid；Weigh 0.5 part of Trivent OCG and 14 parts of Chinese medical extract, glycerol
2 parts, 1 part of essence, 80 DEG C of heating water baths are uniformly mixed, and B liquid is added and is mixed evenly, obtains C solution；While hot by C solution
In ingress pipe, plaster preparation is made.
Embodiment 10: the preparation of aqueogel
1) 0.3 part of Acritamer 940 is weighed, adds 4.0 parts of deionized water, stirring is impregnated 6-12 hours, is uniformly mixed, and card is made
Wave nurse solution A liquid；
2) 2 parts of Chinese medical extract, 1.5 parts of glycerol, 1.5 parts of dehydrated alcohol, 60 DEG C of heating water bath stirring and dissolvings are weighed, and are added
Enter A liquid to be uniformly mixed, obtains B liquid；
3) 0.5 part of azone, 0.2 part of allantoin and 0.5 part of essence are weighed, stirring at normal temperature is uniformly mixed, and the mixing of B liquid is added and stirs
It mixes, homogeneous uniform, obtains hydrogel C solution；
4) 0.1 part of triethylamine solution is weighed, C solution is stirred down, triethylamine solution is slowly added dropwise, by water-setting adhesiveness tune
20mps.s is saved, plastic tube is filled into, external application aqueogel is made.
Embodiment 11: antiphlogistic effects test
Below by way of mouse test, mouse ear swelling anti-inflammatory activity is carried out to the Chinese medicine composition of embodiment 1-8 preparation and is commented
Valence.
Drug and reagent:
Dexamethasone Cream, dimethylbenzene (analyze pure, Sinopharm Chemical Reagent Co., Ltd.), commercially.
Test composition, the Chinese medical extract (medicinal extract) prepared with embodiment 1-8 are distinguished by the method for embodiment 9 or 10
Emplastrum or aqueogel is made, specifically:
Product 1: with the Chinese medical extract of embodiment 1, manufactured aqueogel；
Product 2-3: the Chinese medical extract of embodiment 2 and 3, manufactured plaster preparation are used respectively；
Product 4-8: the Chinese medical extract of embodiment 4-8, manufactured aqueogel are used respectively.
Experimental animal:
ICR mouse, SPF grades, male, weight 22g or so.Experimental animal is limited by the western Poole-Bi Kai experimental animal in Shanghai
Company provides, animal productiong licensing number: SCXK (Shanghai) 2013-0016.Every cage raising animal 10, animal setting room temperature 20~
22 DEG C, humidity 40%~70%, 12 hours light and shade alternatings of illumination.Padding is at least replaced 2 times weekly, while replacing raising box, is met
The box of replacement raising at any time when having abnormal conditions.
Experimental method:
1) animal packet: mouse is randomly divided into 10 groups, respectively model group, Dexamethasone group (positive drug), 1 group of product,
2 groups of product, 3 groups of product, 4 groups of product, 5 groups of product, 6 groups of product, 7 groups of product, 8 groups of product, totally 10 groups, every group 10, respectively
Measurement auris dextra thickness is recorded as 0h auris dextra thickness, and measurement position is that mouse right ear hits exactly position, and same site measures 3 times, makes even
Mean value；
2) dosage and method:
Model group: liquid-transfering gun draws dimethylbenzene (20 μ l/ are only) and is applied to mouse right ear tow sides, remaining does not deal with.In
Thickness is measured after 30 minutes and is recorded.
Dexamethasone group: the forward and backward two sides even spread Dexamethasone ointment 0.1ml/ of mouse right ear only (fills in 0.075mg
Meter Song), it is spaced 30 minutes and is repeated 1 times, be coated with 4 times altogether；
Before product 1 to 8 groups of product, mouse right ear, rear two sides even spread corresponds to emplastrum 0.1ml/ only, is spaced 30 minutes
It is repeated 1 times, is coated with 4 times altogether；
3) cause scorching: remaining each group mouse washes away left drug after last dose 1h in addition to model group, draws dimethylbenzene 20
μ l/ is only spread evenly across the forward and backward two sides of each group mouse right ear；
4) detect: timing causes 30min after inflammation to measure mouse right ear thickness respectively and record, compared with 0h auris dextra thickness, meter
Calculate swelling rate.
Experimental result:
2 groups of animals ear swelling inhibiting rate of table
Can be seen that product 1-2 group according to the above experimental data is control group, is had more stronger than Dexamethasone group anti-inflammatory
Activity, but product 3-8 group shows stronger anti-inflammatory activity than product 1-2 group, it was demonstrated that Six-element Traditional Chinese medicine compound composition of the invention
Composition more careless than three has more preferably effect, shows it with stronger antiphlogistic effects.
Embodiment 12: treatment psoriasis effect experiment
Below by way of mouse test, mouse psoriasis model effect is carried out to the Chinese medicine composition of embodiment 1-8 preparation and is commented
Valence.
Drug and reagent
Imiquimod cream, Halometasone (positive control drug), commercially.
Test composition, the Chinese medical extract (medicinal extract) prepared with embodiment 1-8 are distinguished by the method for embodiment 9 or 10
Emplastrum or aqueogel is made, specifically:
Product 1: with the Chinese medical extract of embodiment 1, manufactured aqueogel；
Product 2-3: the Chinese medical extract of embodiment 2 and 3, manufactured plaster preparation are used respectively；
Product 4-8: the Chinese medical extract of embodiment 4-8, manufactured aqueogel are used respectively.
Experimental animal
ICR mouse, SPF grades, male, weight 22g or so.Experimental animal is limited by the western Poole-Bi Kai experimental animal in Shanghai
Company provides, animal productiong licensing number: SCXK (Shanghai) 2013-0016.Every cage raising animal 10, animal setting room temperature 20~
22 DEG C, humidity 40%~70%, 12 hours light and shade alternatings of illumination.Padding is at least replaced 2 times weekly, while replacing raising box, is met
The box of replacement raising at any time when having abnormal conditions.
Animal model preparation: ICR mouse through intraperitoneal injection of anesthesia, strikes off its back with 1% chloraldurate (0.2ml/20g)
Hair forms the exposed region of 2cm*3cm size, is grouped after single cage raising 1d by group and gives drug-treated.
Experimental method
1) animal packet: mouse is randomly divided into 10 groups, respectively model group, Halometasone group (positive drug), 1 group of product, production
2 groups of product, 3 groups of product, 4 groups of product, 5 groups of product, 6 groups of product, 7 groups of product, 8 groups of product, totally 10 groups, every group 10.
2) dosage and method:
Normal group: mouse periodically gives exposed back daily and smears suitable quantity of water gel bare substrate 0.84mg/ times, and daily 2
It is secondary, continuous 8 days；
Model group: imiquimod 42mg/ times, 1 time a day, successive administration 8 days are smeared in the exposed back of mouse；
Halometasone group: mouse exposed back morning timing smearing imiquimod 42mg/ times, 1 time a day.Afternoon, timing was given
Positive drug Halometasone smears 52mg/ times, 2 times a day, successive administration 8 days；
Product 1-8 administration group: mouse exposed back morning timing smearing imiquimod 42mg/ times, 1 time a day.Afternoon is fixed
When give corresponding 1-8 product and smear 0.84mg/ times, 2 times a day, successive administration 8 days；
3 dosage of table
| Imiquimod | Halometasone | 1-8 product |
| 0.35mg/cm2 | 0.0043mg/cm2 | 0.238mg/cm2 |
3) Testing index and method:
It is corresponding that mouse is given according to each group mouse Pigs with Psoriasis area and disease severity (PASI) standards of grading
Three is integrated addition and obtains total mark, observes the variation feelings of mouse skin lesion by erythema, the scales of skin that peel off and the integral for infiltrating thickened degree
Condition.
Experimental result
4 psoriatic lesion severity scale of table
| Group | It is plump | Erythema | The scales of skin that peel off | Overall score | Skin thickness (mm) |
| Model group | 2.25 | 1.50 | 2.50 | 6.25 | 0.57 |
| Halometasone group | 0 | 0.60 | 1.80 | 2.40 | 0.27 |
| 1 group of product | 0.25 | 1.25 | 1.5 | 3.0 | 0.45 |
| 2 groups of product | 0.20 | 1.80 | 1.4 | 3.4 | 0.35 |
| 3 groups of product | 0.5 | 0 | 0 | 0.5 | 0.30 |
| 4 groups of product | 0.2 | 0.5 | 0 | 0.7 | 0.25 |
| 5 groups of product | 0.1 | 0.3 | 1.0 | 1.4 | 0.35 |
| 6 groups of product | 0 | 0.5 | 0 | 0.5 | 0.32 |
| 7 groups of product | 0.1 | 0.3 | 0.5 | 0.8 | 0.25 |
| 8 groups of product | 0 | 0.3 | 0.5 | 0.8 | 0.27 |
Can be seen that product 1-2 group according to the above experimental data is control group, has treatment silver bits more stronger than Halometasone
Sick effect, but product 3-8 group shows stronger treatment psoriasis effect than control group, it was demonstrated that Six-element Chinese medicine compound prescription group of the invention
Closing object composition more careless than three has more preferably effect, shows that it has effects that stronger treatment psoriasis.
Claims (10)
1. a kind of Chinese medicine composition for treating psoriasis includes following ingredient: garden burnet 10-45%, Asian puccoon according to mass percent
10-45%, madder 5-25%, cortex moutan 5-25%, root of Dahurain angelica 0-20%, Radix Glycyrrhizae 5-25%.
2., according to mass percent, including following ingredient: ground according to the Chinese medicine composition for treating psoriasis described in claim 1
Elm 20-40%, Asian puccoon 20-40%, madder 10-25%, cortex moutan 10-20%, root of Dahurain angelica 0-10%, Radix Glycyrrhizae 10-20%.
3., according to mass percent, including following ingredient: garden burnet according to psoriasis Chinese medicine composition is treated described in claim 1
25-30%, Asian puccoon 25-30%, madder 15-20%, cortex moutan 15-20%, root of Dahurain angelica 0-5%, Radix Glycyrrhizae 15-20%.
4. a kind of Chinese medical extract for treating psoriasis, which is characterized in that the Chinese medical extract is prepared with the following method:
By any Chinese medicine composition of claim 1-3,10 times of alcohols solvents are added and impregnate 12 hours, heat 80 DEG C of refluxing extractions
2 hours；Filtering, the dregs of a decoction add 10 times of alcohols solvents, and heating and refluxing extraction 2 hours；Filtering, merges secondary alcohol solvent extract, and 50
Slurry is concentrated under reduced pressure under DEG C water-bath to get Chinese medical extract.
5. Chinese medical extract according to claim 4, alcohols solvent described in preparation method includes methanol, ethyl alcohol, isopropyl
The small molecules fatty alcohols such as alcohol, preferred alcohol.
6. claim the 1-5 any Chinese medicine composition or extract are in the cosmetics or drug system of preparation treatment psoriasis
Application in agent.
7. applying according to claim 6, the preparation includes hydrogel, emulsion, ointment or emplastrum.
8. apply according to claim 6, the drug or cosmetics further include pharmaceutically or cosmetically allow to add it is medicinal
Auxiliary material or cosmetic.
9. a kind of external application plaster preparation for treating psoriasis, which is characterized in that the emplastrum is prepared by the following method:
1) 1 part of synthetic wax, 3 parts of ceresine, 3 parts of synthetic bees wax are weighed, is merged after 80 DEG C of heating water bath stirring and dissolvings respectively, A liquid；
2) 0.5 part of BHT, 2.5 parts of lanolin, 2.5 parts of albolene, 80 DEG C of heating water bath stirring and dissolvings are weighed, and 1) A is added
Liquid is uniformly mixed, and obtains B liquid；
3) 14 parts of Chinese medical extract, 2 parts of glycerol described in 0.5 part of Trivent OCG and claim 4 are weighed, 1 part of essence, 80 DEG C
Heating water bath is uniformly mixed, and B liquid is added and is mixed evenly, obtains C solution；
4) C solution is imported in vial or other metal tubes while hot, plaster formulation products is made after cooling.
10. a kind of external application aqueogel for treating psoriasis, which is characterized in that the aqueogel is made by the following method
It is standby:
1) 0.3 part of Acritamer 940 is weighed, adds 4.0 parts of deionized water, stirring is impregnated 6-12 hours, is uniformly mixed, and carbomer is made
Solution A liquid；
2) 2 parts of Chinese medical extract, 1.5 parts of glycerol described in claim 4,1.5 parts of dehydrated alcohol, 60 DEG C of heating water bath stirrings are weighed
Dissolution, and A liquid is added and is uniformly mixed, obtain B liquid；
3) 0.5 part of azone, 0.2 part of allantoin and 0.5 part of essence are weighed, stirring at normal temperature is uniformly mixed, be added B liquid be mixed,
Homogeneous uniform obtains hydrogel C solution；
4) 0.1 part of triethylamine solution is weighed, C solution is stirred down, triethylamine solution is slowly added dropwise, hydrogel viscosity-adjusting agent is arrived
External application aqueogel is made in 20mps.s.
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| CN201811156835.0A CN109125443A (en) | 2018-10-08 | 2018-10-08 | A kind of Chinese medicine composition for treating psoriasis |
| CN201910588043.9A CN111000913A (en) | 2018-10-08 | 2019-07-02 | Traditional Chinese medicine composition for treating psoriasis |
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| CN201811156835.0A CN109125443A (en) | 2018-10-08 | 2018-10-08 | A kind of Chinese medicine composition for treating psoriasis |
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| CN117442695A (en) * | 2023-10-25 | 2024-01-26 | 陕西省中医医院 | A Chinese medicinal composition for treating psoriasis, and its preparation method |
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| CN115317538B (en) * | 2022-08-23 | 2023-07-07 | 上海市皮肤病医院 | Externally-applied traditional Chinese medicine composition for treating psoriasis and preparation method and application thereof |
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2018
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| CN117442695A (en) * | 2023-10-25 | 2024-01-26 | 陕西省中医医院 | A Chinese medicinal composition for treating psoriasis, and its preparation method |
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