CN109106931A

CN109106931A - A kind of drug and preparation method thereof for treating intractable renal edema

Info

Publication number: CN109106931A
Application number: CN201810967098.6A
Authority: CN
Inventors: 詹继红
Original assignee: Guiyang College of Traditional Chinese Medicine
Current assignee: Guiyang College of Traditional Chinese Medicine
Priority date: 2018-08-23
Filing date: 2018-08-23
Publication date: 2019-01-01
Anticipated expiration: 2038-08-23
Also published as: CN109106931B

Abstract

The invention discloses a kind of drug and preparation method thereof for treating intractable renal edema, the drug is mainly made by ramulus cinnamomi, Radix Paeoniae Alba, ginger, fennel seeds, Rhizoma Chuanxiong, asarum, pheretima, rhizoma zingiberis and Chinese yam.Each component has synergistic effect well, ramulus cinnamomi warming meridian, helps yang transforming qi in side, and yin is held back in Radix Paeoniae Alba blood-nourishing, and ginger is warming channel and expelling cold, fennel seeds qi-regulating cold dispelling, Rhizoma Chuanxiong blood-activating and qi-promoting, asarum expelling wind and clearing away cold, pheretima dredging collateral dissolving stasis, rhizoma zingiberis warming meridian, Chinese yam reinforcing spleen and kidney.The effect of all medicines share, plays warming and activating meridian altogether, inducing diuresis for removing edema, can be used for treating intractable renal edema, good effect, and have no drug resistance, without side-effects, reach goal of the invention.

Description

A kind of drug and preparation method thereof for treating intractable renal edema

Technical field

The present invention relates to a kind of drugs and preparation method thereof for treating intractable renal edema, belong to field of pharmaceutical technology.

Technical background

Renal edema is because various primary or secondary factors lead to glomerular injury, and filtering function declines, excessive Liquid oedema caused by tissue interval accumulation.Definition in relation to refractory edema, there is presently no unified to define, usually Refer to after the treatment such as diuresis or joint diuresis, the oedema not still being clearly better, often betide clinical various nephrosis, heart failure, Situations such as hepatopathy later period, obstruction of lymphatic return.And renal refractory edema, because to conventional treatment (such as low salt diet, diuresis of reducing swelling Agent) Low Response, often aggravate trend in progressive, be more one of stubborn problem in Kidney Disease, be common in it is primary or In the diseases such as secondary Treating Intractable Nephrotic, diabetic nephropathy.Renal refractory edema is mainly shown as double lower limb severe Pitting edema is difficult to subside notably with ascites or hydrothorax through conventional therapy.And there are many treatment renal edema method now, west The treatment for this disease is cured, mostly uses the methods of diuresis or joint diuresis greatly, effective blood volume deficiency then supplements blood plasma if it exists Albumin, D-40 etc. are disappeared using the single superfine therapy measure of blood purification technology progress ultrafiltration treatment dialysis progress It is swollen.Human serum albumin can be used as one of the drug for using more universal in renal refractory edema treatment means, however because It is blood product, not only expensive, but also there are the risks such as anaphylactic shock, Hematogenous infection, cross multi input albumin It can also increase because of Urine proteins discharge rate, cause glomerular epithelium cell to be damaged, i.e. " protein overloading nephrosis ".And low molecule dextrorotation Sugared acid anhydride can effectively increase blood volume as dextran class drug, to increase kidney perfusion, glomerulus height be caused to filter, Its adverse reaction should also be drawn attention, and many reports point out that D-40 easily leads to anaphylactic shock, acute kidney damage Wound is even dead.Though the above therapy can obtain certain curative effect in a short time, side effect is more, and costly, clinically transports It is prudent with being answered when such therapy.Hemodialysis blood purification treatment is on the one hand larger to patient's damage, on the other hand due to somewhat expensive It returns patient and brings economy and mental burden.

In addition, clinically still or mainly being treated using diuretics in the treatment method of oedema, but often Unsatisfactory, many oedema show as intractable, even if Large dosage of diuretics be difficult to subside, or even because serious water It swells or excessively leads to thromboembolism even renal failure using diuretics, very big puzzlement is brought to clinician.Therefore it seeks It asks a kind of toxic side effect few and measure of effectively reducing swelling, is the heat subject of current medical personnel.

Summary of the invention:

The object of the present invention is to provide a kind of drugs and preparation method thereof for treating intractable renal edema.The medicine Object has the effect of warming and activating meridian, inducing diuresis for removing edema, can be used for treating intractable renal edema, good effect, and have no drug resistance, no pair Effect.

In order to solve the above technical problems, the present invention is implemented with the following technical solutions: a kind of to treat intractable renal edema Drug, calculate by weight, mainly by 200-280 parts of ramulus cinnamomi, 280-320 parts of Radix Paeoniae Alba, 100-140 parts of ginger, fennel seeds 60- 100 parts, 80-120 parts of Rhizoma Chuanxiong, 40-80 parts of asarum, 80-120 parts of pheretima, 130-170 parts of rhizoma zingiberis and 130-170 parts of Chinese yam production It forms.

In the drug for the treatment of intractable renal edema above-mentioned, calculate by weight, mainly by 220-260 parts of ramulus cinnamomi, white 290-310 parts of Chinese herbaceous peony, 110-130 parts of ginger, 70-90 parts of fennel seeds, 90-110 parts of Rhizoma Chuanxiong, 50-70 parts of asarum, pheretima 90-110 Part, 140-160 parts of rhizoma zingiberis and 140-160 parts of Chinese yam are made.

In the drug for the treatment of intractable renal edema above-mentioned, calculate by weight, mainly by 240 parts of ramulus cinnamomi, Radix Paeoniae Alba 300 Part, 120 parts of ginger, 80 parts of fennel seeds, 100 parts of Rhizoma Chuanxiong, 60 parts of asarum, 100 parts of pheretima, 150 parts of rhizoma zingiberis and 150 parts of Chinese yam production It forms.

A kind of production method of the drug for the treatment of intractable renal edema above-mentioned, takes above-mentioned raw materials, customary adjuvant is added, Auxiliary material can also be not added, processed according to common process, pharmaceutical preparation is made.

In the production method of the drug for the treatment of intractable renal edema above-mentioned, the pharmaceutical preparation is external preparation.

It is above-mentioned treatment intractable renal edema drug production method in, the external preparation be pulvis, ointment, Patch, tincture, spraying or gelling agent.

In the production method of the drug for the treatment of intractable renal edema above-mentioned, the production method of the pulvis are as follows: take State drug, after dry, be ground into fine grained to get.

In the production method of the drug for the treatment of intractable renal edema above-mentioned, the production method of the ointment are as follows:

(1) said medicine is taken, the alcohol reflux that 70% is measured with 5-7 times extracts 2-3 times, 0.5-1.5 hours each, extracting solution Filtering, filtrate recycling ethanol and relative density is the medicinal extract of 1.10-1.12 when being condensed into 50-60 DEG C obtain A product；

(2) sorbierite of the amount of being made 3-5% and the glycerol of 3-5% are taken, is added in A product, being heated to 85-90 DEG C makes to dissolve, Obtain B product；

(3) the poly- sorb of the stearic acid of the amount of being made 5-7%, the tristearin of 4-6%, the yellow petroleum jelly of 1-3%, 5-7% are separately taken The sucrose stearate of rouge 80, the lanolin of 0.5-1.5% and 0.5-1.5% is heated to 85-90 DEG C, makes to melt, and obtains C product；

(4) B product and C product mixing and emulsifying 20-30 minutes, 60-70 DEG C heat preservation 50-60 minutes, the amount of being made 0.2-0.5% is added Benzoic acid and 0.1-0.2% ethyl hydroxy benzoate mix, it is filling to get.

In the production method of the drug for the treatment of intractable renal edema above-mentioned, the production method of the patch are as follows:

(2) wool of the rubber of A product weight 30-40%, the rosin of 30-40%, the vaseline of 3-7% and 10-20% is taken Rouge heating melting obtains B product；

(3) B product are added in A product, and 15-30 is mixed with the glycerol of B product weight amount 5-8% and the zinc oxide of 30-50% Minute, spice is obtained, will mount material respectively, and medical mylar and spice are fitted into patch spreading equipment, roll, after forming, Cutting, dispense, sealing, packaging to get.

In the production method of the drug for the treatment of intractable renal edema above-mentioned, the production method of the tincture are as follows: according to Prescription ratio weighs each raw material, add the 8-12 times of soaking in Chinese liquor measured 30 days or more to get.

Drug of the present invention is mainly by ramulus cinnamomi, Radix Paeoniae Alba, ginger, fennel seeds, Rhizoma Chuanxiong, asarum, pheretima, rhizoma zingiberis and Chinese yam system It forms.Wherein, ramulus cinnamomi, nature and flavor acrid, sweet, warm；Channel tropism return heart, lung, bladder meridian.Major function sweating expelling pathogenic factors from muscles and skin, warming meridian help Yang transforming qi, flat gas that spins；For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, arthralgia, phlegm retention, oedema, palpitaition, renal mass. Radix Paeoniae Alba, it is bitter in taste, sour, it is slightly cold；Channel tropism returns liver, the spleen channel.Major function calming the liver and relieving pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating；For having a headache Dizziness, hypochondriac pain, abdominal pain, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.Ginger, nature and flavor are pungent, tepor；Channel tropism is returned Lung, spleen, stomach meridian；Major function relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, preventing phlegm from forming and stopping coughing；For anemofrigid cold, gastrofrigid vomiting, cold phlegm is coughed.It is small Fennel, nature and flavor are acrid in flavour and warm in nature；Channel tropism returns liver,kidney,spleen, stomach meridian；Major function eliminating cold to stop pain, regulating qi-flowing for harmonizing stomach；For cold hernia stomachache, testis The ball swelling and hanging down of either of the testes, dysmenorrhea, abdomen crymodynia, abdominal distention, deficiency of food are vomited and diarrhoea, hydrocele testis；Salt fennel seeds warm up kidney eliminating cold to stop pain.For Cold hernia stomachache, the testis swelling and hanging down of either of the testes, through abdominal pain of trembling with fear.Rhizoma Chuanxiong, nature and flavor are acrid in flavour and warm in nature；Channel tropism returns liver, gallbladder, pericardium channel；Major function promoting blood circulation row Gas, wind-expelling pain-stopping；For irregular menstruation, amenorrhea and algomenorrhea, abdominal mass abdominal pain, pricking pain in the chest, tumbling and swelling, headache, rheumatic arthralgia.Carefully Pungent, nature and flavor are acrid in flavour and warm in nature；Channel tropism return heart, lung, kidney channel；Major function expelling wind and clearing away cold, sensible analgesic, warming lung and resolving fluid；For chill sense It emits, has a headache, toothache, nasosinusitis of having a stuffy nose, rheumatic arthralgia, sputum cough.Pheretima, nature and flavor are salty, tremble with fear.Channel tropism returns liver, spleen, bladder meridian；Function Heat-clearing arresting convulsion can be cured mainly, dredging collateral is relievingd asthma, diuresis；For unconsciousness due to high fever, twitch, arthralgia, extremity numbness, half body is not Then, dyspnea and cough due to lung-heat, oliguria oedema, hypertension.Rhizoma zingiberis, nature and flavor are pungent, warm；Channel tropism returns spleen, stomach, kidney, the heart, lung channel；Major function is dry Ginger warming spleen and stomach for dispelling cold, recover Yang and smooth venation, eliminating dampness dissolving phlegm；For coldness and pain in the epigastrium, vomiting and diarrhea, cold weak pulse of limb, sputum cough.Chinese yam, property Taste sweet and neutral；Channel tropism returns spleen, lung, kidney channel；Major function tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying arresting seminal emission；For spleen eating less, chronic diarrhea Incessantly, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, leukorrhagia, frequent micturition, and abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea Loose stool, leukorrhea.

Drug is made using the above raw material in the present invention, and each component has synergistic effect well, ramulus cinnamomi warming meridian in side, Yin is held back in helps yang transforming qi, Radix Paeoniae Alba blood-nourishing, and ginger is warming channel and expelling cold, fennel seeds qi-regulating cold dispelling, Rhizoma Chuanxiong blood-activating and qi-promoting, asarum expelling wind and clearing away cold, Pheretima dredging collateral dissolving stasis, rhizoma zingiberis warming meridian, Chinese yam reinforcing spleen and kidney.The effect of all medicines share, plays warming and activating meridian altogether, inducing diuresis for removing edema, It can be used for treating intractable renal edema, good effect, and have no drug resistance, it is without side-effects, reach goal of the invention.

Treat example statistics

One, clinical observation:

1, patient's general status

78 intractable renal edema patients, male 32, female 46, the age 18-70 years old, average age 52 ± 5.5.Point Group, treatment group 41, control group 37, protopathy such as table 1:

Table 1 is grouped situation statistics

Grouping	Treatment group's (example)	Control group (example)
			Chronic nephritis	15	13
Diabetic nephropathy	19	18
			Primary nephrotic syndrome	7	6

Except thrombus, embolism person.

2, remedy measures:

2.1 Primary Cares:

2.1.1 general treatment: limit salt is restricted water supply；

2.1.2 it is needed according to the state of an illness conventional using depressor, hormone or immunosuppressor, lipid-loweringing, anticoagulant and support of suiting the medicine to the illness Treatment；

Decompression selection benazepril hydrochloride, Valsartan and/or Levamlodipine beaylate tablets；Hormone or immunosuppressor Select oral prednisone acetate or methylprednisolone piece, cyclophosphamide or ciclosporin A or mycophenolate mofetil；Lipid-loweringing selection atropic is cut down Statin；Anticoagulant selection low molecular weight heparin.Symptomatic treatment selects frusemide intravenous drip 120-140mg/d..

2.1.2.1 blood pressure raising person, give plus use ACEI/ARB or CCB etc., make fluctuation of blood pressure in 140/90mmHg or less；

2.1.2.2 the high person of blood glucose, giving adjustment insulin level makes glycemic control in empty stomach 6-8mmol/L, postprandial 2 hours Between 12-13mmol/L；

2.2 treatment groups: all patients are in Primary Care plus are applied with Chinese medicine (preparing by embodiment 1) of the present invention, have Body are as follows: drug of the present invention is modulated into paste with 45-55 DEG C or so of warm water, the drug modulated is spread on into about 2cm on gauze Gauze is spread on patient's double lower limb, Shuan Shenqu by left and right thickness；There is ascites person to add and spreads on navel (SHENQUE acupoint).Infrared lamp is added to shine After penetrating 20-30min, waits 5min to wait for that residual temperature disperses and remove gauze.1-2 times daily.

2.3 control group only Primary Care.

3, the course for the treatment of

15d is the observation time limit.

4, observation index

1. observing the situation of change of pretherapy and post-treatment patient's edematous site oedema degree.2. pretherapy and post-treatment twenty-four-hour urine egg White, twenty-four-hour urine amount, oedema integral variation.Oedema ranking criterion (1): 1 point, ankle and following oedema；2 points, oedema before shin is in Pitting edema is not referred to by it；3 points, oedema before shin, finger submerged while pressing；4 points, double lower limb and double edema of the upper extremity；5 points, with slurry Membrane cavity hydrops.

5, evaluation criterion

Effective: the symptoms such as oedema, out of strength are obviously improved, and urine protein content significantly reduces, and urine volume obviously increases, oedema integral Compared with decreaseing beyond 70% before treatment；Effective: the symptoms such as oedema, out of strength make moderate progress, and urine protein content is reduced, and urine volume is Increase, decline 30%~70% before oedema integral is relatively treated；Invalid: the symptoms such as oedema, out of strength, urine volume, Urine proteins are unchanged, Oedema integral is dropped by less than 30% before relatively treating.It is effective to be added up to always effectively with effective.

6, statistical analysis analyzes data using 19.0 statistical software of SPSS.

7, result

7.1 pretherapy and post-treatment twenty-four-hour urine albumen, twenty-four-hour urine amount, oedema integral contrast (table 1)

The pretherapy and post-treatment twenty-four-hour urine albumen of table 2, twenty-four-hour urine amount, oedema integral contrast

Note: compared with before treatment:^*P<0.05；Compared with treatment group⁺P<0.05。

As can be seen from Table 2, twenty-four-hour urine amount before treatment than significantly increasing, twenty-four-hour urine albumen, water using after drug of the present invention Swollen integral substantially reduces before relatively treating.

7.2 curative effects compare

After treatment, Cure is counted, the results are shown in Table 3.

3 Cure of table statistics

Seen from table 3, drug of the present invention can treat intractable renal edema, curative effect affirmative.

Typical case

Liu, female 38 years old, are diagnosed as nephrotic syndrome, edema of pair of lower extremities, by recess be not easy to restore, abdominal distension is received Difference, sign of ascites (+) oliguria, color are yellow, (urine volume 500ml/24h or so), routine urinalysis: PRO+++, RBC5-8/HP, for 24 hours Urine proteins 4.2g/L.Through diuresis (frusemide 120mg/d), prednisone acetate tablets take orally (55mg/d) 5 days oedema and aggravate day by day, and urine volume is without bright Aobvious to increase, after carrying out treatment 5 days using drug of the present invention (being prepared by embodiment 1) in this Primary Care, symptom improves, Urine volume increases to 1400-1800ml/d and continues to use to symptom after 15 days to be restored completely, and check routine urinalysis: PRO (+) urinates for 24 hours Albumen 2.11g/L.Subsequent follow-up 1 time weekly, continues 6 months, does not recur.

Mr. Wang, male 29 years old, is diagnosed as diabetic nephropathy, the following oedema of waist, by recess do not rise, hypourocrinia (400ml/d or so), abdominal distension, nausea, routine urinalysis: PRO++, BLD+, for 24 hours Urine proteins 3.05g/L, by oral administration benazepril hydrochloride 10mgBid decompression, 30R insulin morning 12u, evening 16u subcutaneous injection, gradually dosage is quiet to 140mg/d for oral medicinal herb and frusemide The arteries and veins drop state of an illness is not relieved.In Primary Care plus with after drug of the present invention (being prepared by embodiment 1) 5 days, hence it is evident that It improves, urine volume increases to 1000ml/d or so, continues to use to oedema after 10 days and obviously subside, only slight water before double lower limb shin Swollen, urine volume reaches 2100ml/d, malaise symptoms disappear, and check routine urinalysis: PRO (+), for 24 hours Urine proteins 2.03g/L.Then weekly with It visits 1 time, continues 6 months, stable disease.

Liu, male 25 years old, are diagnosed as chronic nephritis, double lower limb to thigh root pitting edema, finger submerged while pressing, mind Fatigue, four limbs burnout, hypourocrinia (600-800ml/24h), routine urinalysis: PRO+++, BLD+, Urine proteins 3.3g/L, passes through for 24 hours Oral hydrochloride benazepil 10mgQd decompression, oral medicinal herb and frusemide from 80mg/ times gradually dosage to 140mg/d intravenous drip The state of an illness is not relieved.In this Primary Care, after drug of the present invention (being prepared by embodiment 1) 5 days, hence it is evident that good Turning, urine volume increases to 1100ml/d or so, and it continues to use to oedema after 10 days and obviously subsides, only Mild edema before double lower limb shin, Urine volume reaches 2000-2300ml/d, malaise symptoms disappear, and check routine urinalysis: PRO (+), for 24 hours Urine proteins 1.83g/L.Then weekly Follow-up 1 time, continue 6 months, stable disease.

Compared with prior art, the present invention using ramulus cinnamomi, Radix Paeoniae Alba, ginger, fennel seeds, Rhizoma Chuanxiong, asarum, pheretima, rhizoma zingiberis and The effect of Chinese yam is made drug, and each component raw material has a good synergistic function, complete square compatibility 5, plays inducing diuresis for removing edema living altogether, can use In treatment intractable renal edema, good effect, and have no drug resistance, it is without side-effects, reach goal of the invention.

Invention is further described below with reference to embodiment, but is not intended as the foundation limited the present invention.

Specific embodiment:

Embodiment 1.

Formula: ramulus cinnamomi 240g, Radix Paeoniae Alba 300g, ginger 120g, fennel seeds 80g, Rhizoma Chuanxiong 100g, asarum 60g, pheretima 100g, Rhizoma zingiberis 150g and Chinese yam 150g.

Technique: said medicine is taken to be ground into fine grained after dry to get pulvis.

Usage and dosage: medicinal powder made of the above method is modulated into paste with 45-55 DEG C or so of warm water, by what is modulated Drug is spread on gauze, and gauze is spread on to the edematous site of patient, after baking 20-30min with infra-red roast light, 5-10min is waited to wait for Residual temperature, which disperses, removes gauze.1-2 times daily.The course for the treatment of is 7-10 days.

Embodiment 2.

Formula: ramulus cinnamomi 260g, Radix Paeoniae Alba 310g, ginger 130g, fennel seeds 90g, Rhizoma Chuanxiong 110g, asarum 70g, pheretima 110g, Rhizoma zingiberis 160g and Chinese yam 160g.

Technique: the following steps are included:

(1) said medicine is taken, is extracted 2 times with the alcohol reflux of 6 times of amounts 70%, 1 hour every time, extracting solution filtered, filtrate The medicinal extract that relative density is 1.10-1.12 when recycling ethyl alcohol and being condensed into 50-60 DEG C, obtains A product；

(2) sorbierite of the amount of being made 4% and 4% glycerol are taken, is added in A product, being heated to 85-90 DEG C makes to dissolve, and obtains B Product；

(3) stearic acid of the amount of being made 6%, 5% tristearin, 2% yellow petroleum jelly, 6% poly- sorb rouge 80,1% are separately taken Lanolin and 1% sucrose stearate be heated to 85-90 DEG C, make to melt, obtain C product；

(4) B product and C product mixing and emulsifying 25 minutes, 60-70 DEG C keeps the temperature 55 minutes, be added the amount of being made 0.4% benzoic acid and 0.15% ethyl hydroxy benzoate mixes, filling to get ointment.

Usage and dosage: external application is applied to affected part, and each 4-6h smears primary.

Embodiment 3.

Formula: it ramulus cinnamomi 220g, Radix Paeoniae Alba 290g, ginger 110g, fennel seeds 70g, Rhizoma Chuanxiong 90g, asarum 50g, pheretima 90g, does Ginger 140g and Chinese yam 140g.

Technique: the following steps are included:

(2) 35% rubber of A product weight, 35% rosin, 5% vaseline and 15% lanolin heating melting are taken, Obtain B product；

(3) B product are added in A product, are mixed 23 minutes with the glycerol of B product weight amount 6% and 40% zinc oxide, obtain medicine Material, will mount material respectively, and medical mylar and spice are fitted into patch spreading equipment, roll, and after forming, cut, packing, Sealing is packed to get patch.

Claims

1. a kind of drug for treating intractable renal edema, it is characterised in that: calculate by weight, mainly by ramulus cinnamomi 200-280 Part, 280-320 parts of Radix Paeoniae Alba, 100-140 parts of ginger, 60-100 parts of fennel seeds, 80-120 parts of Rhizoma Chuanxiong, 40-80 parts of asarum, pheretima 80-120 parts, 130-170 parts of rhizoma zingiberis and 130-170 parts of Chinese yam are made.

2. the drug for the treatment of intractable renal edema as described in claim 1, it is characterised in that: calculate by weight, mainly By 220-260 parts of ramulus cinnamomi, 290-310 parts of Radix Paeoniae Alba, 110-130 parts of ginger, 70-90 parts of fennel seeds, 90-110 parts of Rhizoma Chuanxiong, asarum 50-70 parts, 90-110 parts of pheretima, 140-160 parts of rhizoma zingiberis and 140-160 parts of Chinese yam are made.

3. the drug for the treatment of intractable renal edema as claimed in claim 2, it is characterised in that: calculate by weight, mainly By 240 parts of ramulus cinnamomi, 300 parts of Radix Paeoniae Alba, 120 parts of ginger, 80 parts of fennel seeds, 100 parts of Rhizoma Chuanxiong, 60 parts of asarum, 100 parts of pheretima, rhizoma zingiberis 150 parts and 150 parts of Chinese yam are made.

4. a kind of production method of the drug for the treatment of intractable renal edema as claimed in any one of claims 1-3, special Sign is: taking above-mentioned raw materials, auxiliary material is added, or auxiliary material is not added, is processed according to common process, pharmaceutical preparation is made.

5. the production method of the drug for the treatment of intractable renal edema as claimed in claim 4, it is characterised in that: the medicine Object preparation is external preparation.

6. the production method of the drug for the treatment of intractable renal edema as claimed in claim 5, it is characterised in that: described outer It is pulvis, ointment, patch, tincture, spraying or gelling agent with preparation.

7. the preparation method of the drug for the treatment of intractable renal edema as claimed in claim 6, it is characterised in that: the pulvis Production method are as follows: take said medicine, after dry, be ground into fine grained to get.

8. the production method of the drug for the treatment of intractable renal edema as claimed in claim 6, it is characterised in that: the ointment The production method of agent are as follows:

(1) said medicine is taken, the alcohol reflux that 70% is measured with 5-7 times extracts 2-3 times, 0.5-1.5 hours each, extracting solution mistake Filter, filtrate recycling ethanol and relative density is the medicinal extract of 1.10-1.12 when being condensed into 50-60 DEG C obtain A product；

(2) sorbierite of the amount of being made 3-5% and the glycerol of 3-5% are taken, is added in A product, being heated to 85-90 DEG C makes to dissolve, and obtains B Product；

(3) separately take the stearic acid of the amount of being made 5-7%, the tristearin of 4-6%, the yellow petroleum jelly of 1-3%, 5-7% poly- sorb rouge 80, The lanolin of 0.5-1.5% and the sucrose stearate of 0.5-1.5% are heated to 85-90 DEG C, make to melt, and obtain C product；

(4) B product and C product mixing and emulsifying 20-30 minutes, 60-70 DEG C heat preservation 50-60 minutes, the benzene of the amount of being made 0.2-0.5% is added The ethyl hydroxy benzoate of formic acid and 0.1-0.2% mix, it is filling to get.

9. the production method of the drug for the treatment of intractable renal edema as claimed in claim 6, it is characterised in that: the patch Production method are as follows:

(2) lanolin of the rubber of A product weight 30-40%, the rosin of 30-40%, the vaseline of 3-7% and 10-20% is taken to add Heat fusing obtains B product；

(3) B product are added in A product, are mixed 15-30 minutes with the glycerol of B product weight amount 5-8% and the zinc oxide of 30-50%, Spice is obtained, will mount material respectively, and medical mylar and spice are fitted into patch spreading equipment, roll, after forming, cutting, Packing, sealing, packaging to get.

10. the production method of the drug for the treatment of intractable renal edema as claimed in claim 6, it is characterised in that: the tincture The production method of agent are as follows: weigh each raw material according to prescription ratio, add the 8-12 times of soaking in Chinese liquor measured 30 days or more to get.