CN109106600A - Glue transportation system and preparation method - Google Patents
Glue transportation system and preparation method Download PDFInfo
- Publication number
- CN109106600A CN109106600A CN201710487939.9A CN201710487939A CN109106600A CN 109106600 A CN109106600 A CN 109106600A CN 201710487939 A CN201710487939 A CN 201710487939A CN 109106600 A CN109106600 A CN 109106600A
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- Prior art keywords
- glue
- box
- liquid level
- tank
- pipeline
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- 239000003292 glue Substances 0.000 title claims abstract description 363
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 74
- 238000000034 method Methods 0.000 claims description 15
- 239000008188 pellet Substances 0.000 claims description 12
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 10
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 6
- -1 Febuxostat Amine Chemical class 0.000 claims description 5
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims description 4
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 3
- RMSGQZDGSZOJMU-UHFFFAOYSA-N 1-butyl-2-phenylbenzene Chemical group CCCCC1=CC=CC=C1C1=CC=CC=C1 RMSGQZDGSZOJMU-UHFFFAOYSA-N 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 108010020326 Caspofungin Proteins 0.000 claims description 3
- 108010013198 Daptomycin Proteins 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- GZOSMCIZMLWJML-VJLLXTKPSA-N abiraterone Chemical compound C([C@H]1[C@H]2[C@@H]([C@]3(CC[C@H](O)CC3=CC2)C)CC[C@@]11C)C=C1C1=CC=CN=C1 GZOSMCIZMLWJML-VJLLXTKPSA-N 0.000 claims description 3
- 229960000853 abiraterone Drugs 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 235000001465 calcium Nutrition 0.000 claims description 3
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 claims description 3
- 229960003034 caspofungin Drugs 0.000 claims description 3
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 3
- 229960002227 clindamycin Drugs 0.000 claims description 3
- DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 claims description 3
- 229960005484 daptomycin Drugs 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 229960005101 febuxostat Drugs 0.000 claims description 3
- 235000021323 fish oil Nutrition 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- VMMKGHQPQIEGSQ-UHFFFAOYSA-N minodronic acid Chemical compound C1=CC=CN2C(CC(O)(P(O)(O)=O)P(O)(O)=O)=CN=C21 VMMKGHQPQIEGSQ-UHFFFAOYSA-N 0.000 claims description 3
- 229950011129 minodronic acid Drugs 0.000 claims description 3
- 229960002296 paroxetine Drugs 0.000 claims description 3
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims description 3
- 229960003089 pramipexole Drugs 0.000 claims description 3
- 229960000278 theophylline Drugs 0.000 claims description 3
- 229960000200 ulipristal Drugs 0.000 claims description 3
- OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 229960000987 paricalcitol Drugs 0.000 claims description 2
- BPKAHTKRCLCHEA-UBFJEZKGSA-N paricalcitol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1C[C@@H](O)C[C@H](O)C1 BPKAHTKRCLCHEA-UBFJEZKGSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- IMOZEMNVLZVGJZ-QGZVFWFLSA-N apremilast Chemical compound C1=C(OC)C(OCC)=CC([C@@H](CS(C)(=O)=O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)=C1 IMOZEMNVLZVGJZ-QGZVFWFLSA-N 0.000 claims 1
- 229960001164 apremilast Drugs 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 6
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 6
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 6
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000007901 soft capsule Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- JWJOTENAMICLJG-QWBYCMEYSA-N dutasteride Chemical compound O=C([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)N[C@@H]4CC3)C)CC[C@@]21C)NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F JWJOTENAMICLJG-QWBYCMEYSA-N 0.000 description 2
- 229960004199 dutasteride Drugs 0.000 description 2
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 2
- NEMGRZFTLSKBAP-LBPRGKRZSA-N safinamide Chemical compound C1=CC(CN[C@@H](C)C(N)=O)=CC=C1OCC1=CC=CC(F)=C1 NEMGRZFTLSKBAP-LBPRGKRZSA-N 0.000 description 2
- 229950002652 safinamide Drugs 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/078—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of wafers or cachets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/70—Device provided with specific sensor or indicating means
- A61J2200/76—Device provided with specific sensor or indicating means for fluid level
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Coating Apparatus (AREA)
Abstract
A kind of glue transportation system and preparation method, glue transportation system the including: glue tank, compressed air pipe, glue outflow pipeline, the first glue box and the second glue box, the first liquid level sensor and the second liquid level sensor and the first pneumatic control valve and the second pneumatic control valve.
Description
Technical field
The present invention relates to field of pharmaceutical equipment, and glue is delivered to pellet processing machine cloth from glue tank is changed in particular to a kind of
Glue transportation system and preparation method in glue device, in particular to a kind of glue transportation system for soft capsule device for producing a granulated material.
Background technique
As shown in Figure 1, being commonly used for glue transportation system the including: glue tank 1 of soft capsule device for producing a granulated material, glue box 5, supplying
Glue pump 7 and control cabinet 9；Change glue tank 1 for storing glue；Gumming pump 7 is used to for glue being supplied to from glue tank 1 is changed via pipeline
Glue box 5；Glue box 5 are used to receive the glue from glue tank 1 is changed；Control cabinet 9 is used to control the operation of gumming pump 7.
The pipeline of connectionization glue tank 1, gumming pump 7 and glue box 5 is provided with pipeline heater 3, and pipeline heater 3 is used for pipe
Glue in road is heated, and causes to solidify since temperature reduces when not flowing for a long time to avoid glue, to influence
Product quality.
Liquid level sensor 4 is provided in glue box 5.Liquid level sensor 4 is used to detect the height of the liquid level in glue box 5, and root
Different signals is exported to control cabinet 9 according to the height of liquid level.
Programmable controller (PLC) is provided in control cabinet 9.PLC receives the signal from liquid level sensor 4, and is based on
The signal received controls the frequency of frequency converter, to control the revolving speed of gumming pump 7.
But according to the above-mentioned prior art, the component and control element in system are more, this will lead to the manufacture of system
Cost increases, and space is needed to carry out separately installed control cabinet.
In addition, glue pipeline needs whole heating and thermal insulation due to technological reason.Due to system control glue pipeline compared with
It is long, it is therefore desirable at least 5 groups of heater, and it is not appropriate to the heater heated to gumming pump.Work as equipment downtime
And glue is for a long time when flowing, the glue temperature in gumming pump can reduce, this may result in generation solidification phenomenon, Jin Erying
Ring product quality.
In addition, can run out of steam after passing fully through gumming pump due to glue in the final stage of single batch production, so
It will lead to and remain a large amount of glues with pipeline thereafter inside gumming pump.For the glue that these can not be used, Zhi Neng
It is rinsed out when pipeline cleaning with ejected wash water.It will cause biggish wastage of material in this way, to improve the production cost of enterprise.
In addition, cleaning needs to dismantle gumming pump into cleaning every time, this can increase due to having dead angle in the cavity of gumming pump
Add cleaning time.
In addition, equipment downtime, glue can generate reflux, cause in pipeline when the glue for changing glue tank is ready for use
Air entrance is had, and these air can pour glue box when being switched on again, so as to cause the promotion of product quality risk.
Summary of the invention
In order to solve to come across the above problem and/or other problems of correlative technology field, this invention address that providing one
Kind glue transportation system and preparation method.Detection signal of the system based on liquid level sensor, using compressed air by glue
Glue box are supplied to from glue tank is changed, so that the glue in system be enable all to be provided to glue box, and easily control glue box
In glue amount.
According to an aspect of the invention, there is provided a kind of glue transportation system, may include: glue tank, are used for
Store glue；Compressed air pipe is connected to describedization glue tank and pure compressed air is supplied to describedization glue tank；Glue
Pipeline, the bottom of one end being connected to glue tank are flowed out, other end bifurcated is the first branch and second branch；First glue box and
Two glue box, first glue box flow out the first branch the being connected to glue tank of pipeline, second glue box by the glue
Second branch the being connected to glue tank of pipeline is flowed out by the glue, is come from so that the first glue box and the second glue box be made to receive
Change the glue of flow container；First liquid level sensor and the second liquid level sensor, first liquid level sensor are set to described first
Glue box, second liquid level sensor are set to second glue box, are respectively used in the first glue box of detection and the second glue box
The liquid level of glue；First pneumatic control valve and the second pneumatic control valve, first pneumatic control valve are set to described first
Road is opened or closed according to the output signal of the first liquid level sensor, and second pneumatic control valve is set to described second
Branch is opened or closed according to the output signal of the second liquid level sensor.
When the first liquid level sensor detects that the glue liquid level in the first glue box is greater than first predetermined value, the first pneumatic control
Valve processed can close, and pipeline can not be flowed out via glue and flow to the first glue box from glue tank is changed by changing the glue in glue tank；When
When two liquid level sensors detect that the glue liquid level in the second glue box is greater than first predetermined value, the second pneumatic operated valve can be closed, and be changed
Glue in glue tank can not flow out pipeline via glue and flow to the second glue box from glue tank is changed；When the first liquid level sensor detects
When being less than second predetermined value to the glue liquid level in the first glue box, the first pneumatic control valve can be opened, and change the glue in glue tank
Pipeline can be flowed out via glue and flow to the first glue box from glue tank is changed；When the second liquid level sensor detects in the second glue box
When glue liquid level is less than second predetermined value, the second pneumatic operated valve can be opened, and the glue changed in glue tank can be via glue effuser
Road and from change glue tank flow to the second glue box.
First pneumatic control valve may include: the first solenoid valve, according to the output signal of the first liquid level sensor
And it runs；First operated pneumatic valve is opened or closed according to the operation of the first solenoid valve.
Second pneumatic control valve may include: second solenoid valve, according to the output signal of the second liquid level sensor
And it runs；Second operated pneumatic valve is opened or closed according to the operation of second solenoid valve.
In addition, the glue transportation system may include the first button switch, it is used to control the controlled of glue transportation system
State, when first switch button is pressed, system is in and manually controls state, when first switch button is in reset state
When, system is in automatic control state.
In addition, the glue transportation system may include the second button switch, the case where manually controlling state is in system
Under, when second switch button is pressed, glue can not flow to the first glue box and the second glue box from glue tank is changed, and work as second switch
When button is in reset state, glue can flow to the first glue box and the second glue box from glue tank is changed.
In addition, the glue transportation system may include pipeline heater, it is sheathed on the outside of the glue outflow pipeline,
For being heated to the glue in glue outflow pipeline.
In addition, the glue transportation system may include pressure reducing valve, it is set to compressed air pipe and changes between glue tank, with
Pressure in adjustingization glue tank.
In addition, the glue transportation system may include upper process valve, it is set to the glue outflow pipeline, and be located at
Change between glue tank and pneumatic control valve, whether the upper process valve controls glue according to the signal of upper process can be from change glue tank
Outflow.
In addition, the glue transportation system may include pellet processing machine, it is set to the lower section of glue box, is flowed out with receiving from glue box
Glue.
According to another aspect of the present invention, a kind of preparation method of pharmaceutical preparation is additionally provided, this method may include
The glue containing active pharmaceutical ingredient is supplied using glue transportation system above-mentioned, exhibition glue is then carried out, cooling, draws skin, pill
The step of.It is preferred that the pharmaceutical preparation is soft capsule preparation.
Further, the active pharmaceutical ingredient can selected from butylphenyl phthaleine, safinamide, Febuxostat, minodronic acid, Ah
Pu Site, song Ge Lieting, liquid calcium, vitamin E, fish oil (to be polyunsaturated fatty acid rich in ω -3, for example (22 DHA
Carbon acid), the derivative of or mixtures thereof EPA (eicosapentaenoic acid) and DHA or EPA), A-D ostelin, dutasteride,
Paricalcitol, Daptomycin, Ou Liwan star, clindamycin, Paxil, Ulipristal, Pramipexole, according to bent theophylline, perseverance
Lattice arrange net, side Da Palu, Caspofungin, abiraterone.
Glue transportation system according to the present invention, the glue in system can all be provided to glue box, and easily
The amount of the glue in glue box is controlled, so that the manufacturing cost of system reduces and structure is simplified, and nothing in system
Remaining glue, thus easy to clean, material is maximally utilized, and prepares and produce post purge time before saving production.
Detailed description of the invention
The detailed description presented when by later in conjunction with attached drawing will be more clearly understood it is of the invention above and its
Its purpose, feature and advantage, in the drawings:
Fig. 1 is to show the schematic diagram of the glue transportation system of full-automatic device for producing a granulated material in the prior art；
Fig. 2 is to show the schematic diagram of glue transportation system according to the present invention；
Fig. 3 schematically shows the schematic diagram of the control element of glue transportation system according to the present invention.
Specific embodiment
It will be detailed with reference to each embodiment of the invention, the example of these embodiments is shown in the accompanying drawings simultaneously
It is described as follows.Although the present invention will be combined with an exemplary implementation and be described, it should be understood that this specification is not intended to
Limit the invention to those exemplary implementation schemes.On the contrary, the present invention is directed to not only cover these exemplary implementation schemes, and
And covering can be included in various selection forms within the spirit and scope of the present invention being defined by the appended claims,
Modification, equivalent form and other embodiments.
Fig. 2 is the schematic diagram of the glue transportation system of each embodiment according to the present invention.With reference to Fig. 2, glue conveying
System may include: glue tank 100, compressed air pipe 900, glue flow out pipeline 1100, glue box 500, liquid level sensor 400
And pneumatic control valve 300.
Changing glue tank 100 can store glue.The top for changing glue tank 100 can connect to compressed air pipe 900, change glue tank
100 bottom can connect to the first end of glue outflow pipeline 1100.Such as cylindrical body, length can be formed as by changing glue tank 100
The shapes such as cube, square, but it is not limited to this.In addition, (for example, 316L stainless steel) can be made of metal by changing glue tank 100,
But it is not limited to this.
When compressed air is from 900 inflowization glue tank 100 of compressed air pipe, change the pressure rise in glue tank 100,
When changing the pressure in glue tank 100 greater than ambient pressure, glue flows out pipeline 1100 via glue and flows out.Particularly, it is working
Period, changing the pressure in glue tank 100 to be is about 50Pa to 150Pa, preferably 80Pa.
Compressed air pipe 900 will change glue tank 100 and be connected with the supplier tank for supplying compressed air, be used for pure pressure
Contracting air supply extremely changes glue tank 100.(for example, 316L stainless steel) is made by metal or plastics in compressed air pipe 900, has circle
Tee section, but it is not limited to this.In addition, the pressure of the compressed air in compressed air pipe 900 is about 50Pa to 150Pa,
Preferably 80Pa.
Glue flows out pipeline 1100 and is connected glue tank 100 is changed with glue box 500 (for example, welding, grafting etc.), thus making
Glue in glue tank 100 can flow to glue box 500.Glue flows out the bottom of first end the being connected to glue tank 100 of pipeline 1100,
The other end bifurcated that glue flows out pipeline 1100 is the first branch 1101 and second branch 1102.Glue flows out pipeline 1100 can be with
With circular cross-section, but it also can have other shapes (for example, rectangle etc.).Glue flows out pipeline 1100 by metal material
(for example, 316L stainless steel) is made, which can be identical as the material of being made glue tank 1, or can also be made
The material for changing glue tank 1 is different.Glue box 500 are set to glue outflow pipeline 1100, and are located at the downstream for changing glue tank 100, are used for
It receives from the glue for changing glue tank 100, and glue is supplied to pellet processing machine 600 to make capsule.
Preferably, glue box 500 may include the first glue box 510 and the second glue box 520, and the first glue box 510 pass through glue stream
Out the second end bifurcated of pipeline 1100 go out the first branch 1101 and being connected to glue tank 100, the second glue box 520 pass through glue stream
Out the second end bifurcated of pipeline 1100 go out second branch 1102 and being connected to glue tank.
As shown in Fig. 2, the first glue box 510 are cylindrical body on top, it is inverted cone in lower part；The top of the cylindrical body
With entrance, so that glue can flow into；The bottom (near one end of pellet processing machine) of the inverted cone has outlet, so that
Glue can flow out.First glue box 510 are made of copper or stainless steel, preferably copper.
In the preferred embodiment of the application, the second glue box 520 can have shape identical with the first glue box 510,
Certainly, also can have different shapes in other embodiments, and the second glue box 520 can by with the first glue box 510
Identical or different material is made.
Liquid level sensor 400 is set to glue box 500 and is electrically connected to pellet processing machine control cabinet 700, is used to detect glue box
The liquid level of glue in 500, and by sensing signal transmission to pill machine controller 700.
Preferably, liquid level sensor 400 may include the first liquid level sensor 410 and the second liquid level sensor 420.
First liquid level sensor 410 is set to the first glue box 510, can detecte the amount of the glue in the first glue box 510,
And the signal for the amount for being related to glue that will test is transmitted to pellet processing machine control cabinet 700.Specifically, when the first liquid level sensor
410 when detecting that glue level in the first glue box 510 is greater than the first predeterminated level, the first signal of output to pellet processing machine control cabinet
700；When the first liquid level sensor 410 detects the glue level in the first glue box 510 less than the second predeterminated level, output the
Binary signal is to pellet processing machine control cabinet 700.
It here, the first liquid level sensor 410 is not limited to this, but may include that can measure in the first glue box 510
Any sensor (for example, inductance type transducer) of the amount of glue.
Second liquid level sensor 420 is similar with the first liquid level sensor 410, is not described herein.In addition, the second liquid
Level sensor 420 can use and the different types of sensor of the first liquid level sensor 410.
Pneumatic control valve 300 is set to glue outflow pipeline 1100, and is located at and changes between glue tank 100 and glue box 500, connects
The output signal from liquid level sensor 400 is received, and is opened or closed according to the output signal of liquid level sensor 400.According to
Pneumatic control valve 300 opens or closes, and the liquid level of the glue in glue box 500 can be maintained at certain level, thus guarantee from
The glue that glue box 500 flow out has stable flow velocity appropriate.
Preferably, pneumatic control valve 300 may include the first pneumatic control valve 310 and the second pneumatic control valve 320.Below
First pneumatic control valve 310 will be described in detail.
First pneumatic control valve 310 is set to the first branch 1101 of glue outflow pipeline 1100, and is located at and changes glue tank
Downstream.When the first pneumatic control valve 310 is received from the first signal of liquid level sensor 400, the first pneumatic control valve 310
It closes, the glue in glue outflow pipeline 1100 cannot flow to the first glue box 510；Come when the first pneumatic control valve 310 receives
When from the second signal of liquid level sensor 400, the first pneumatic control valve 310 is opened, and glue flows out the glue in pipeline 1100 not
The first glue box 510 can be flow to.
In other words, when the glue in the first glue box 510 is excessive, the first pneumatic control valve 310 is closed, to prevent glue stream
The glue in pipeline 1100 continues to flow to the first glue box 510 out；When the glue in the first glue box 510 is very few, the first pneumatic control
Valve 310 processed is opened, to allow the glue in glue outflow pipeline 1100 to flow to the first glue box 510.
First pneumatic control valve 310 may include the first solenoid valve 311 and the first operated pneumatic valve 312, the first operated pneumatic valve
312 open or close according to the operation of the first solenoid valve 311.It should be understood that the first pneumatic control valve 310 is not limited to
This, but all kinds of control valves including can be realized fluid block function.
Second pneumatic control valve 320 is similar with the first pneumatic control valve 310, therefore no longer it is described in detail.
It should be noted that pneumatic control valve 320 can use and the different types of control valve of the first pneumatic control valve 310.
Further, glue transportation system may include pellet processing machine 600, can be set in the lower section of glue box 500, to receive
Glue from glue box 500.
Further, glue transportation system may include upper process valve 200, be set to glue outflow pipeline 1100, and
Positioned at pneumatic control valve 500 and change between glue tank 100.Upper process valve 200 can be according to the glue for example changed in glue tank 100
Quality and open or close, to guarantee the quality of glue.
Specifically, for example, when changing the quality of glue in glue tank 100 and reaching standard, upper process is by upper process valve
200 controls is open, and when the quality for changing the glue in glue tank 100 is not up to standard, upper process controls upper process valve 200
To close.
Further, glue transportation system may include pipeline heater 800, be sheathed on glue outflow pipeline 1100, from
And the glue in glue outflow pipeline 11 is heated, it prevents from influencing product quality since glue solidifies.Specifically, pipe
Channel heater 800 is about 55-65 DEG C temperature, preferably 60 DEG C degree at runtime.
Preferably, a pipeline heater 800 only can be set to glue outflow pipeline 1100.But the present invention is simultaneously
It is without being limited thereto, multiple pipeline heaters 800 can also be set to glue outflow pipeline 1100.
Further, glue transportation system may include pressure reducing valve 1000, compressed air pipe 900 is set to, according to change
Pressure size in glue tank 100 and open or close, so that the pressure changed in glue tank 100 is maintained at a certain range.The decompression
Valve 1000 can be to manually control or automatically control.
Fig. 3 is the schematic diagram of the control element of the glue transportation system of each embodiment according to the present invention.
With reference to Fig. 3, the control element of glue transportation system may include: electromagnetic valve coil KM, intermediate relay KA, first
Switch SB1 and second switch SB2.
Preferably, electromagnetic valve coil KM includes the first electromagnetic valve coil KM1 and second solenoid valve coil KM2, intermediate relay
Device KA includes the first intermediate relay KA1 and the second intermediate relay KA2.The first electromagnetic valve coil KM1 is described more fully below
With the operation of the first intermediate relay KA1.
As shown in figure 3, first switch SB1 is self-locking button switch, it is used to control glue transport control system for place
In automatically controlling or manually control.Specifically, glue transport control system is in automatic control when first switch SB1 is pressed
State processed, when first switch SB1 is in reset state, glue transport control system is in and manually controls state.
When glue transport control system is in automatic control state, controlled according to the sensing signal of liquid level sensor 400
Pneumatic control valve 300 processed.Specifically, the normally-closed contact of SB1 disconnects and normally opened contact is led when first switch SB1 is pressed
Logical, liquid level sensor 400 is powered.Preferably, liquid level sensor 400 is the sensor of PNP type.
In the case, when the first liquid level sensor 410 detects that the liquid level in the first glue box 510 is greater than first predetermined value
When, the first liquid level sensor 410 exports high level, the coil in the first intermediate relay KA1 is connected, so that among first
The normally opened contact of relay KA1 is closed, so that it is electric to obtain the first electromagnetic valve coil KM1, the movement of the first solenoid valve 311, the first gas
Movable valve 312 is closed, to make the first pneumatic control valve 310 close and stop for glue.
When the first liquid level sensor 410 detects that the liquid level in the first glue box 510 is less than second predetermined value, the first liquid level
Sensor 410 exports low level, to disconnect the coil in the first intermediate relay KA1, so that the first intermediate relay KA1's is normal
Contact disconnection is opened, to make the first electromagnetic valve coil KM1 power loss, the first solenoid valve 311 is failure to actuate, and operated pneumatic valve 312 is opened, from
And the first pneumatic control valve 310 is made to open and start for glue.
When glue transportation system, which is in, manually controls state, it is pneumatic that first is controlled according to the operation of second switch SB2
Control valve 310.Specifically, the normally-closed contact closure and normally opened contact of SB1 is disconnected when first switch SB1 is in reset state
It opens, liquid level sensor 400 powers off.
In the case, when second switch SB2 is pressed, normally opened contact closure so that electromagnetic valve coil KM obtain it is electric,
So that the first solenoid valve 311 and second solenoid valve 321 act, the first operated pneumatic valve 312 and second starts the closing of valve 322, from
And it closes pneumatic control valve 300 and stops for glue.
When second switch SB2 is in reset state, normally opened contact is disconnected, so that electromagnetic valve coil KM power loss, so that
First solenoid valve 311 and second solenoid valve 321 are failure to actuate, and the first operated pneumatic valve 312 and second starts the unlatching of valve 322, thus
Pneumatic control valve 300 is opened and is started for glue.
It it should be understood that the control system in the present invention is not limited to this, but include that all this control may be implemented
All kinds of electric elements combination.
Using the glue transportation system of each embodiment according to the present invention, the preparation of pharmaceutical preparation can be carried out.Cause
This, the present invention also provides a kind of preparation method of pharmaceutical preparation, this method contains medicine using above-mentioned glue transportation system supply
The glue of object active constituent.
Specifically, under the control of pellet processing machine control cabinet 700, make being stored in glue tank 100 containing pharmaceutical activity at
Point glue pass through upper process valve 200, the first pneumatic control valve 310 and the second pneumatic control valve 320 and respectively supplied to the
One glue box 510 and the second glue box 520, so that the glue containing active pharmaceutical ingredient is supplied to pellet processing machine 600, and with laggard
Row exhibition glue, draws skin, pill at cooling.
Preferably, pharmaceutical preparation can be soft capsule preparation.But the pharmaceutical preparation is without being limited thereto, or its
The pharmaceutical preparation of his type.
In addition, the active pharmaceutical ingredient can be butylphenyl phthaleine, safinamide, Febuxostat, minodronic acid, A Pusi
Spy, song Ge Lieting, liquid calcium, vitamin E, fish oil (to be polyunsaturated fatty acid rich in ω -3, for example DHA (22 carbon six
Olefin(e) acid), the derivative of or mixtures thereof EPA (eicosapentaenoic acid) and DHA or EPA), A-D ostelin, dutasteride, pa it is vertical
Ostelin, Daptomycin, Ou Liwan star, clindamycin, Paxil, Ulipristal, Pramipexole, according to bent theophylline, permanent lattice column
Only, side Da Palu, Caspofungin, abiraterone.But the active pharmaceutical ingredient is without being limited thereto, or other types
Active pharmaceutical ingredient.
It can be substantially change in the specific embodiment of invention described herein, this modification falls into the present invention
In claimed spirit and scope.It should be pointed out that all items for including herein are illustrative and do not limit the present invention
Range.
Claims (12)
1. a kind of glue transportation system characterized by comprising
Change glue tank, is used to store glue；
Compressed air pipe is connected to describedization glue tank and pure compressed air is supplied to describedization glue tank；
Glue flows out pipeline, the bottom of one end being connected to glue tank, and other end bifurcated is the first branch and second branch；
First glue box and the second glue box, first glue box flow out the first branch the being connected to glue of pipeline by the glue
Tank, second glue box by the glue flow out pipeline second branch being connected to glue tank, thus make the first glue box with
Second glue box are received from the glue for changing flow container；
First liquid level sensor and the second liquid level sensor, first liquid level sensor is set to first glue box, described
Second liquid level sensor is set to second glue box, is respectively used to the liquid of detection the first glue box and the glue in the second glue box
Position；
First pneumatic control valve and the second pneumatic control valve, first pneumatic control valve are set to the first branch, according to
The output signal of first liquid level sensor and open or close, second pneumatic control valve is set to the second branch, root
It is opened or closed according to the output signal of the second liquid level sensor.
2. glue transportation system according to claim 1, it is characterised in that:
When the first liquid level sensor detects that the glue liquid level in the first glue box is greater than first predetermined value, the first pneumatic control valve
It closes, pipeline can not be flowed out via glue and flow to the first glue box from glue tank is changed by changing the glue in glue tank；
When the second liquid level sensor detects that the glue liquid level in the second glue box is greater than first predetermined value, the second pneumatic operated valve is closed
It closes, pipeline can not be flowed out via glue and flow to the second glue box from glue tank is changed by changing the glue in glue tank；
When the first liquid level sensor detects that the glue liquid level in the first glue box is less than second predetermined value, the first pneumatic control valve
It opens, pipeline can be flowed out via glue and flow to the first glue box from glue tank is changed by changing the glue in glue tank；
When the second liquid level sensor detects that the glue liquid level in the second glue box is less than second predetermined value, the second pneumatic operated valve is opened
It opens, pipeline can be flowed out via glue and flow to the second glue box from glue tank is changed by changing the glue in glue tank.
3. glue transportation system according to claim 1, which is characterized in that first pneumatic control valve includes:
First solenoid valve is run according to the output signal of the first liquid level sensor；
First operated pneumatic valve is opened or closed according to the operation of the first solenoid valve.
4. glue transportation system according to claim 1, which is characterized in that second pneumatic control valve includes:
Second solenoid valve is run according to the output signal of the second liquid level sensor；
Second operated pneumatic valve is opened or closed according to the operation of second solenoid valve.
5. glue transportation system according to claim 1, which is characterized in that further comprise the first button switch, use
In control glue transportation system slave mode,
When first switch button is pressed, system is in and manually controls state,
When first switch button is in reset state, system is in automatic control state.
6. glue transportation system according to claim 5, which is characterized in that further comprise the second button switch, be
System is in the case where manually control state, and when second switch button is pressed, glue can not flow to first from glue tank is changed
Glue box and the second glue box, when second switch button is in reset state, glue can flow to the first glue box and the from glue tank is changed
Two glue box.
7. glue transportation system according to claim 1, which is characterized in that further comprise pipeline heater, be arranged
In the outside of glue outflow pipeline, for being heated to the glue in glue outflow pipeline.
8. glue transportation system according to claim 1, which is characterized in that further comprise pressure reducing valve, be set to pressure
Between contracting air pipeline and change glue tank, with the pressure in adjustingization glue tank.
9. glue transportation system according to claim 1, which is characterized in that it further comprise upper process valve, setting
Pipeline is flowed out in the glue, and is located at and changes between glue tank and pneumatic control valve, the upper process valve is according to the letter of upper process
Number and control glue whether can from change glue tank outflow.
10. glue transportation system according to claim 1, which is characterized in that further comprise pellet processing machine, be set to glue
The lower section of box, to receive the glue flowed out from glue box.
11. a kind of preparation method of pharmaceutical preparation is supplied using glue transportation system described in claim 1-10 any one
To the glue containing active pharmaceutical ingredient, the preferably described pharmaceutical preparation is soft gelatin pharmaceutical preparation.
12. preparation method according to claim 11, feature is selected from butylphenyl phthaleine, husky fragrant acyl in the active pharmaceutical ingredient
Amine, minodronic acid, Apremilast, song Ge Lieting, liquid calcium, vitamin E, fish oil, A-D ostelin, spends his hero at Febuxostat
Amine, paricalcitol, Daptomycin, Ou Liwan star, clindamycin, Paxil, Ulipristal, Pramipexole, according to bent theophylline,
Permanent lattice arrange net, side Da Palu, Caspofungin, abiraterone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710487939.9A CN109106600A (en) | 2017-06-23 | 2017-06-23 | Glue transportation system and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710487939.9A CN109106600A (en) | 2017-06-23 | 2017-06-23 | Glue transportation system and preparation method |
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| Publication Number | Publication Date |
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| CN109106600A true CN109106600A (en) | 2019-01-01 |
Family
ID=64732149
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710487939.9A Pending CN109106600A (en) | 2017-06-23 | 2017-06-23 | Glue transportation system and preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110421827A (en) * | 2019-06-21 | 2019-11-08 | 北京鑫航成科技发展有限公司 | A kind of high-speed silent valve material feeding encapsulating machine |
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| CN207666885U (en) * | 2017-06-23 | 2018-07-31 | 江苏恒瑞医药股份有限公司 | Glue transport system |
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| KR101182497B1 (en) * | 2011-05-18 | 2012-09-12 | 창성소프트젤 주식회사 | A manufacturing equipment of vegetable gelatin capsule |
| CN203392491U (en) * | 2013-06-04 | 2014-01-15 | 北京长征天民高科技有限公司 | Glue solution conveying device used for vegetable gum soft capsule device |
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| CN110421827A (en) * | 2019-06-21 | 2019-11-08 | 北京鑫航成科技发展有限公司 | A kind of high-speed silent valve material feeding encapsulating machine |
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