CN109091404A - 一种具有祛痘美颜作用的复方龙血竭面膜及其制备方法 - Google Patents
一种具有祛痘美颜作用的复方龙血竭面膜及其制备方法 Download PDFInfo
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Abstract
本发明一种具有祛痘美颜作用的复方龙血竭面膜及其制备方法，是将中药龙血竭和丹参等中药提取物与保湿剂、增稠剂、防腐剂等辅料经科学方法制备而成的一种具有抗氧化、美白、活血化瘀、祛腐生肌、抑制痤疮病原菌和祛痘美颜等作用的面膜。该面膜制备简单，无刺激性，不掉色，是面部美容与保健，特别是祛痘美颜的最佳面膜。
Description
技术领域
本发明属面膜研发技术领域，具体涉及一种具有祛痘美颜作用的复方龙血竭面膜及其制备方法。
背景技术
面膜作为美容保养品的一种载体，现使用十分广泛，随着人们物质生活水平的提高，对面膜的要求越来越高，从开始使用面膜是为了保养美容，至现在治疗面部疾病的一种需求，因此，在这样的背景下，本发明提供一种具有祛痘美颜作用的龙血竭面膜及其制备方法。
龙血竭为传统名贵药材，使用已有几千年的历史，具有活血化瘀、祛腐生肌、止血收敛、消肿止痛作用，被称为“和血之圣药”。现在研究表明，采用抑制痤疮病原菌实验对龙血竭提取液进行祛痘功效评价，证明其对金黄色葡萄球菌和痤疮丙酸杆菌均有抑制作用。通过自由基清除能力实验和酪氨酸酶抑制实验对龙血竭提取液抗氧化和美白功效进行评价，证明其有显著的抗氧化和美白效果。
金银花提取物，具有抗菌及增强免疫功能的作用：试验表明金银花对葡萄球菌、链球菌、等均有抑制作用，效果显著。
黄芩提取物，抗微生物作用强，有较广的抗菌谱，对痢疾杆菌、白喉杆菌、绿脓杆菌、葡萄球菌、链球菌、肺炎双球菌以及脑膜炎球菌等均有抑制作用，是一种很好的功能性美容化妆品原料
互生叶白千层叶提取物，是澳洲的一种茶树精油，具有解毒和强力的消炎杀菌功效，是一种很好的祛痘美容化妆品原料；
丹参提取物，具有抗菌及增强免疫功能的作用和抑制耐药菌蛋白质合成。
龙血竭与上述金银花提取物、黄芩提取物、互生叶白千层叶提取物和丹参提取物合用制备成面膜，对于改善皮肤状态及缓解皮肤慢性疾病如青春痘等会有很好的效果。
发明内容
本发明一种具有祛痘美颜作用的复方龙血竭面膜及其制备方法，具有抗氧化、美白、活血化瘀、祛腐生肌，抑制痤疮病原菌，祛痘美颜等作用。本发明是通过下述技术方案实现的：配方：
(1)按重量份计，保湿剂0.5-10份、透明质酸0.01-3份、增稠剂0.05-2份、中药复方提取物0.01-2份、龙血竭提取物0.01-2份、防腐剂0.05-1份、甘草酸二钾0.1-10份、泛醇0.01-10份及60-90份水组成。
(2)优选的，保湿剂8份、透明质酸2份、增稠剂1份、中药复方提取物2份、龙血竭提取物1份、防腐剂0.5份、甘草酸二钾5份、泛醇0.5份、水80份组成。
所述保湿剂为丁二醇、甘油、海藻糖、甘油聚醚-26、银耳多糖、甜菜碱、聚甲基丙烯酸甘油酯、丙二醇和PVM/MA共聚物的混合物；
所述增稠剂为黄原胶。
所述中药复方提取物为金银花提取物，黄芩提取物，互生叶白千层叶提取物及丹参提取物的混合物，按重量份计：金银花提取物：黄芩提取物：互生叶白千层叶提取物：丹参提取物＝2∶2∶1∶2。
所述防腐剂为双咪唑烷基脲。
所述水是指纯化水或去离子水或蒸馏水。
所述一种具有祛痘美颜作用的龙血竭面膜，具有抗氧化，美白，活血化瘀、祛腐生肌，抑制痤疮病原菌，祛痘美颜等作用。
制备工艺：取上述配方(1)中所述组成：
1)称取黄原胶加水使其溶胀为胶状，得胶状液，备用；
2)依次称取丁二醇、甘油、海藻糖、甘油聚醚-26、银耳多糖、甜菜碱、聚甲基丙烯酸甘油酯、丙二醇、PVM/MA共聚物、泛醇、龙血竭提取物、中药复方提取甘草酸二钾加水溶解，得溶解液备用；
3)将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸和双咪唑烷基脲，搅拌并混合均匀，得面膜液，备用；
4)取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
有益效果
本发明一种具有祛痘美颜作用的复方龙血竭面膜及其制备方法，是将中药龙血竭和丹参等中药提取物与保湿剂、增稠剂、防腐剂等辅料经科学方法制备而成的一种具有抗氧化，美白，活血化瘀、祛腐生肌，抑制痤疮病原菌，祛痘美颜等作用的面膜。该面膜制备简单，无刺激性，不掉色，是面部美容与保健，特别是祛痘美颜的最佳面膜。
具体实施例：(按100份制备)
下面结合实施例对本发明作进一步地详细说明，但本发明的实施方式不限于此。
实施例1
1)称取黄原胶2份加水30份使其溶胀为胶状，得胶状液，备用；
2)依次称取丁二醇1份、甘油3份、海藻糖0.2份、甘油聚醚-260.5份、银耳多糖0.4份、甜菜碱0.5份、聚甲基丙烯酸甘油酯0.1份、丙二醇0.4份、PVM/MA共聚物0.2份、泛醇0.7份、龙血竭提取物0.5份、中药复方提取1份、甘草酸二钾3份，加少量水搅拌使其溶解，得溶解液备用；
3)将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸1份和双咪唑烷基脲0.3份，补加水至100份，搅拌并混合均匀，用150-300目筛网过滤，得面膜液，备用；
4)取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
实施例2
1)称取黄原胶1份加水40份使其溶胀为胶状，得胶状液，备用；
2)依次称取丁二醇0.5份、甘油4份、海藻糖1份、甘油聚醚-260.5份、银耳多糖0.5份、甜菜碱0.5份、聚甲基丙烯酸甘油酯0.3份、丙二醇0.5份、PVM/MA共聚物0.2份、泛醇0.8份、龙血竭提取物0.08份、中药复方提取1.5份、甘草酸二钾2份，加少量水搅拌使其溶解，得溶解液，备用；
3)将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸2份和双咪唑烷基脲0.5份，补加水至100份，搅拌并混合均匀，用150-300目筛网过滤，得面膜液，备用；
4)取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
实施例3
1)称取黄原胶1份加水40份使其溶胀为胶状，得胶状液，备用；
2)依次称取丁二醇2份、甘油1份、海藻糖1份、甘油聚醚-261份、银耳多糖0.5份、甜菜碱0.5份、聚甲基丙烯酸甘油酯0.5份、丙二醇1.0份、PVM/MA共聚物0.5份、泛醇0.7份、龙血竭提取物0.5份、中药复方提取1份、甘草酸二钾3份，加少量水搅拌使其溶解，得溶解液备用；
3)将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸2份和双咪唑烷基脲0.5份，补加水至100份，搅拌并混合均匀，用150-300目筛网过滤，得面膜液，备用；
4)取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
实施例4
1)称取黄原胶1份加水30份使其溶胀为胶状，得胶状液，备用；
2)依次称取丁二醇3份、甘油3份、海藻糖0.02份、甘油聚醚-260.05份、银耳多糖0.4份、甜菜碱0.7份、聚甲基丙烯酸甘油酯0.1份丙二醇0.3份、PVM/MA共聚物0.1份、泛醇0.5份、龙血竭提取物1份、中药复方提取0.5份、甘草酸二钾5份，加少量水搅拌使其溶解，得溶解液备用；
3)将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸1.5份和双咪唑烷基脲1份，补加水至100份，搅拌并混合均匀，用150-300目筛网过滤，得面膜液，备用；
4)取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
实施例5
1)称取黄原胶1.5份加水40份使其溶胀为胶状，得胶状液，备用；
2)依次称取丁二醇1.5份、甘油2份、海藻糖0.05份、甘油聚醚-260.5份、银耳多糖0.4份、甜菜碱0.6份、聚甲基丙烯酸甘油酯0.2份、丙二醇0.2份、PVM/MA共聚物0.1份、泛醇2份、龙血竭提取物1份、中药复方提取1份、甘草酸二钾2份，加少量水搅拌使其溶解，得溶解液备用；
3)将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸1份和双咪唑烷基脲0.3份，补加水至100份，搅拌并混合均匀，用150-300目筛网过滤，得面膜液，备用；
4)取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
实施例6
1)称取黄原胶1份加水30份使其溶胀为胶状，得胶状液，备用；
2)依次称取丁二醇2份、甘油2.5份、海藻糖0.6份、甘油聚醚-26 0.8份、银耳多糖0.5份、甜菜碱0.1份、聚甲基丙烯酸甘油酯0.1份丙二醇0.2份、PVM/MA共聚物0.2份、泛醇1份、龙血竭提取物1.5份、中药复方提取0.5份、甘草酸二钾2份，加少量水搅拌使其溶解，得溶解液备用；
3)将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸1.5份和双咪唑烷基脲0.5份，补加水至100份，搅拌并混合均匀，用150-300目筛网过滤，得面膜液，备用；
4)取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
上述实施例中，实施例3所制备的龙血竭面膜不论在外观和色泽等方面为最佳。
实施例7
龙血竭面膜液抑制痤疮病原菌研究
1材料
1.1试药
龙血竭面膜液；云南大唐汉方制药股份有限公司，批号180706
红霉素；大连美罗大药厂，批号180901
改良GAM肉汤培养基；自制
改良GAM琼脂培养基；自制
生理盐水：青岛尼赛欣和生物技术有限公司提供，批号180901
羊血：市场购买
1.2实验菌株：痤疮丙酸杆菌冻干菌株：中国食品药品检定研究院
1.3仪器：立式压力蒸汽灭菌器；平板培养皿；厌氧培养箱；微量移液器；试管
2方法与结果
2.1痤疮丙酸杆菌的复苏和菌悬液的制备：
改良6AM琼脂培养基115℃高压灭菌15min后加入5％羊血，倾倒在平板培养皿内，以此用作冻干菌株的复苏平板。利用平板划线法将冻干菌株接种至平板内，37℃厌氧培养48h后，挑取单个生长的菌落至改良GAM肉汤培养基，稀释调整为0.5个麦氏比浊单位(约为1.5×108CFU/mL)。
2.2菌落计数
移取上述菌悬液0.500mL，加至装有4.5mL生理盐水的试管中，得到稀释10倍的菌液。再移取0.5mL稀释10倍的菌液至4.5mL生理盐水中，得到稀释102倍的菌液。依次稀释，直至得到稀释108倍的菌液，移取1mL至平板培养基上，均匀涂布，37℃厌氧培养48h，对生长的菌落进行计数。
2.3琼脂稀释平板的制备
取6支无菌试管，第1管加入4mL龙血竭面膜溶液(2g/mL)，2～6管加入4mL蒸馏水，第2管再加4mL龙血竭面膜液，2～6管依次做倍比稀释。将改良GAM琼脂培养基加热熔化，无菌操作吸取16ml培养基加至上述试管中，混匀倾注于平板中。使琼脂平板中药液倍比稀释度分别为1∶5，1∶10，1∶20，1∶40，1∶80，1∶160，药物浓度分别为400，200，100，50，25，12.5mg/mL。
配制红霉素溶液(浓度为3mg/mL)，按上述方法制备对照组平板，得对照药物平板浓度分别为600，300，150，75，47.5，23.75mg/mL，空白对照平板(20ml培养基)、溶剂对照平板(16ml培养基+4ml蒸馏水)。
2.4接种琼脂稀释平板
将制备好的菌悬液点种2μL于各个含药平板的表面，置厌氧培养箱中，37℃培养24h。2.5最小抑菌浓度(MIC)的判定
将平板置于暗色、无反光物体表面，观察能够完全抑制细菌生长的最低药液浓度，为对痤疮丙酸杆菌的最低抑菌浓度(MIC)。结果见表1和表2，结果表明龙血竭面膜液最低抑菌浓度(按生药计)对痤疮丙酸杆菌为100mg/mL，其对引起痤疮的主要致病菌存在抑制作用。
表1 红霉素对痤疮丙酸杆菌的抑制作用
注：“-”表示细菌不生长，“+”表示细菌生长。
表2 龙血竭面膜对痤疮丙酸杆菌的抑制作用
注：“-”表示细菌不生长，“+”表示细菌生长。
Claims (10)
1.一种具有祛痘美颜作用的龙血竭面膜及其制备方法，其特征在于按重量份计是由保湿剂0.5-10份、透明质酸0.01-3份、增稠剂0.05-2份、中药复方提取物0.01-2份、龙血竭提取物0.01-2份、防腐剂0.05-1份、甘草酸二钾0.1-10份、泛醇0.01-10份及60-90份水组成。
2.如权利要求1所述一种具有祛痘美颜作用的龙血竭面膜，其特征在于优选的由保湿剂8份、透明质酸2份、增稠剂1份、中药复方提取物2份、龙血竭提取物1份、防腐剂0.5份、甘草酸二钾5份、泛醇0.5份、水80份组成。
3.如权利要求1或2所述保湿剂为丁二醇、甘油、海藻糖、甘油聚醚-26、银耳多糖、甜菜碱、聚甲基丙烯酸甘油酯、丙二醇和PVM/MA共聚物的混合物。
4.如权利要求1或2所述增稠剂为黄原胶。
5.如权利要求1或2所述中药复方提取物为金银花提取物，黄芩提取物，互生叶白千层叶提取物及丹参提取物的混合物，按重量份计：金银花提取物∶黄芩提取物∶互生叶白千层叶提取物∶丹参提取物＝2∶2∶1∶2。
6.如权利要求1或2所述防腐剂为双咪唑烷基脲。
7.如权利要求1或2所述水是指纯化水或去离子水或蒸馏水。
8.如权利要求1所述制备方法，取权利要求1所述的组成，其特征在于制备方法如下：
8.1称取黄原胶加水使其溶胀为胶状，得胶状液，备用；
8.2依次称取丁二醇、甘油、海藻糖、甘油聚醚-26、银耳多糖、甜菜碱、聚甲基丙烯酸甘油酯、丙二醇、PVM/MA共聚物、泛醇、龙血竭提取物、中药复方提取甘草酸二钾加水溶解，得溶解液备用；
8.3将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸和双咪唑烷基脲，搅拌并混合均匀，得面膜液，备用；
8.4取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
9.如权利要求1或8所述制备方法，其特征在于优选与下述制备方法：
9.1称取黄原胶1份加水40份使其溶胀为胶状，得胶状液，备用；
9.2依次称取丁二醇2份、甘油1份、海藻糖1份、甘油聚醚-261份、银耳多糖0.5份、甜菜碱0.5份、聚甲基丙烯酸甘油酯0.5份、丙二醇1份、PVM/MA共聚物0.5份、泛醇0.7份、龙血竭提取物0.5份、中药复方提取1份、甘草酸二钾3份，加少量水搅拌使其溶解，得溶解液备用；
9.3将上述胶状液与溶解液混合并搅拌均匀，加热至80℃，保温10-20min后，降温至30-40℃左右，加入透明质酸2份和双咪唑烷基脲0.5份，补加水至100份，搅拌并混合均匀，用150-300目筛网过滤，得面膜液，备用；
9.4取膜材折叠装入袋中，每袋倒入上述面膜液25份，封口，即得。
10.如权利要求1或2所述一种具有祛痘美颜作用的龙血竭面膜，具有抗氧化，美白，活血化瘀、祛腐生肌，抑制痤疮病原菌，祛痘美颜等作用。
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