CN109070082A - 具有整合泵送、调平和感测的模块化器官微生理*** - Google Patents
具有整合泵送、调平和感测的模块化器官微生理*** Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
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- C12M23/12—Well or multiwell plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B23/00—Pumping installations or systems
- F04B23/04—Combinations of two or more pumps
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B23/00—Pumping installations or systems
- F04B23/04—Combinations of two or more pumps
- F04B23/06—Combinations of two or more pumps the pumps being all of reciprocating positive-displacement type
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract
Description
第7天的功能(n=3) | 仅肝细胞 | 肝细胞+库普弗细胞(10:1) |
白蛋白(μg/天/mg) | 35±11 | 53±32 |
尿素(μg/天/mg) | 175±75 | 184±25 |
CYP3A(pmol/分钟/mg) | 2.9±0.5 | 2.0±0.7 |
Claims (29)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662291102P | 2016-02-04 | 2016-02-04 | |
US62/291,102 | 2016-02-04 | ||
US201662359567P | 2016-07-07 | 2016-07-07 | |
US62/359,567 | 2016-07-07 | ||
PCT/US2017/016721 WO2017176357A2 (en) | 2016-02-04 | 2017-02-06 | Modular organ microphysiological system with integrated pumping, leveling, and sensing |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109070082A true CN109070082A (zh) | 2018-12-21 |
CN109070082B CN109070082B (zh) | 2021-10-15 |
Family
ID=59409751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780020751.1A Active CN109070082B (zh) | 2016-02-04 | 2017-02-06 | 具有整合泵送、调平和感测的模块化器官微生理*** |
Country Status (5)
Country | Link |
---|---|
US (2) | US10876088B2 (zh) |
EP (2) | EP3411150A2 (zh) |
JP (1) | JP6942361B2 (zh) |
CN (1) | CN109070082B (zh) |
WO (1) | WO2017176357A2 (zh) |
Cited By (5)
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CN110795853A (zh) * | 2019-11-01 | 2020-02-14 | 西南石油大学 | 一种油气钻井过程中早期溢流层位随钻识别方法 |
CN113825831A (zh) * | 2019-05-13 | 2021-12-21 | 纽索思创新有限公司 | 用于细胞培养的微流控装置和方法 |
CN114912215A (zh) * | 2022-04-25 | 2022-08-16 | 安徽理工大学 | 一种具有高吸能特性的锚喷支护托盘的拓扑结构优化方法 |
WO2022222209A1 (zh) * | 2021-04-19 | 2022-10-27 | 杭州优思达生物技术有限公司 | 一种自驱动微流控检测装置及其用途 |
CN115651841A (zh) * | 2022-11-09 | 2023-01-31 | 昆明医科大学第一附属医院 | 视网膜多种细胞共培养的装置及培养方法 |
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EP3411150A2 (en) * | 2016-02-04 | 2018-12-12 | Massachusetts Institute of Technology | Modular organ microphysiological system with integrated pumping, leveling, and sensing |
WO2018009870A1 (en) * | 2016-07-07 | 2018-01-11 | David Beebe | Microtiter plate and uses thereof |
US11261414B2 (en) | 2016-11-14 | 2022-03-01 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Apparatus for reconfiguration of components in a microphysiological system |
EP3572498A4 (en) * | 2017-01-18 | 2020-11-18 | Shinko Chemical Co., Ltd. | DEVICE FOR EVALUATION OF CHEMICAL SUBSTANCES AND METHOD FOR EVALUATION OF CHEMICAL SUBSTANCES |
USD932046S1 (en) * | 2017-03-10 | 2021-09-28 | 908 Devices Inc. | Fluidic cartridge assembly |
EP3600668B1 (en) | 2017-03-21 | 2022-01-26 | Massachusetts Institute of Technology | Modular organ microphysiological system with microbiome |
WO2018187808A1 (en) * | 2017-04-07 | 2018-10-11 | Epibone, Inc. | System and method for seeding and culturing |
US11285471B2 (en) * | 2017-05-30 | 2022-03-29 | Nextern Innovation, Llc | Portable controlled micro-environment device for modular bio-processing |
US11649424B2 (en) | 2017-07-28 | 2023-05-16 | The Trustees Of Columbia University In The City Of New York | Smart micro bioreactor platform for high throughput mechanical stimulation of cardiac microtissue |
US10729839B2 (en) | 2017-10-03 | 2020-08-04 | Baxter International Inc. | Modular medical fluid management assemblies, machines and methods |
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US10722635B2 (en) | 2017-10-03 | 2020-07-28 | Baxter International Inc. | Modular medical fluid management assemblies and associated machines and methods |
RU2668157C1 (ru) * | 2017-11-23 | 2018-09-26 | Общество с ограниченной ответственностью научно-технический центр "БиоКлиникум" (ООО НТЦ "БиоКлиникум") | Устройство для формирования двухслойной клеточной модели |
TWI699494B (zh) * | 2018-01-24 | 2020-07-21 | 美商伊路米納有限公司 | 流體緩衝 |
US20190330584A1 (en) | 2018-03-19 | 2019-10-31 | Massachusetts Institute Of Technology | Organ-on-chip platforms with reduced fluid volume |
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RU184220U1 (ru) * | 2018-04-10 | 2018-10-18 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | Клеточная ячейка микрофлюидного чипа для культивирования и/или исследования клеток или клеточных моделей |
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CN115651841A (zh) * | 2022-11-09 | 2023-01-31 | 昆明医科大学第一附属医院 | 视网膜多种细胞共培养的装置及培养方法 |
CN115651841B (zh) * | 2022-11-09 | 2023-11-10 | 昆明医科大学第一附属医院 | 视网膜多种细胞共培养的装置及培养方法 |
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EP3932555A1 (en) | 2022-01-05 |
US20170227525A1 (en) | 2017-08-10 |
EP3411150A2 (en) | 2018-12-12 |
US10876088B2 (en) | 2020-12-29 |
US11732229B2 (en) | 2023-08-22 |
JP6942361B2 (ja) | 2021-09-29 |
CN109070082B (zh) | 2021-10-15 |
WO2017176357A2 (en) | 2017-10-12 |
WO2017176357A3 (en) | 2018-01-04 |
US20210139829A1 (en) | 2021-05-13 |
JP2019505214A (ja) | 2019-02-28 |
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