CN109054010A - 一种咪唑环修饰的酸敏感聚碳酸酯材料及其制备和应用 - Google Patents
一种咪唑环修饰的酸敏感聚碳酸酯材料及其制备和应用 Download PDFInfo
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- CN109054010A CN109054010A CN201810768062.5A CN201810768062A CN109054010A CN 109054010 A CN109054010 A CN 109054010A CN 201810768062 A CN201810768062 A CN 201810768062A CN 109054010 A CN109054010 A CN 109054010A
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- acid
- imidazole ring
- sensitive
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
- C08G64/183—Block or graft polymers containing polyether sequences
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/20—General preparatory processes
- C08G64/30—General preparatory processes using carbonates
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/42—Chemical after-treatment
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810768062.5A CN109054010B (zh) | 2018-07-13 | 2018-07-13 | 一种咪唑环修饰的酸敏感聚碳酸酯材料及其制备和应用 |
Applications Claiming Priority (1)
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CN201810768062.5A CN109054010B (zh) | 2018-07-13 | 2018-07-13 | 一种咪唑环修饰的酸敏感聚碳酸酯材料及其制备和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109054010A true CN109054010A (zh) | 2018-12-21 |
CN109054010B CN109054010B (zh) | 2022-08-16 |
Family
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Family Applications (1)
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CN201810768062.5A Active CN109054010B (zh) | 2018-07-13 | 2018-07-13 | 一种咪唑环修饰的酸敏感聚碳酸酯材料及其制备和应用 |
Country Status (1)
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CN (1) | CN109054010B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110507634A (zh) * | 2019-09-16 | 2019-11-29 | 湖北大学 | 一种电荷翻转型中空介孔硅基药物载体***及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104387573A (zh) * | 2014-11-29 | 2015-03-04 | 沈阳药科大学 | 一种维生素e修饰的肠溶聚碳酸酯的制备及在口服给药中的应用 |
CN105792814A (zh) * | 2013-12-05 | 2016-07-20 | 国际商业机器公司 | 用于药物递送的载有芳香族n-杂环的聚碳酸酯 |
CN106822916A (zh) * | 2017-01-25 | 2017-06-13 | 浙江大学 | 一种pH敏感的纳米化Bcl‑2选择性抑制剂的制备方法及产物和应用 |
CN107163255A (zh) * | 2017-04-21 | 2017-09-15 | 四川大学 | 氧化还原和pH双重响应的无规‑接枝型药物载体及方法 |
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2018
- 2018-07-13 CN CN201810768062.5A patent/CN109054010B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105792814A (zh) * | 2013-12-05 | 2016-07-20 | 国际商业机器公司 | 用于药物递送的载有芳香族n-杂环的聚碳酸酯 |
US20170281662A1 (en) * | 2013-12-05 | 2017-10-05 | International Business Machines Corporation | Polycarbonates bearing aromatic n-heterocycles for drug delivery |
CN104387573A (zh) * | 2014-11-29 | 2015-03-04 | 沈阳药科大学 | 一种维生素e修饰的肠溶聚碳酸酯的制备及在口服给药中的应用 |
CN106822916A (zh) * | 2017-01-25 | 2017-06-13 | 浙江大学 | 一种pH敏感的纳米化Bcl‑2选择性抑制剂的制备方法及产物和应用 |
CN107163255A (zh) * | 2017-04-21 | 2017-09-15 | 四川大学 | 氧化还原和pH双重响应的无规‑接枝型药物载体及方法 |
Non-Patent Citations (1)
Title |
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LIANG JU等: "Preparation and properties evaluation of a novel pH-sensitive liposomes based on imidazole-modified cholesterol derivatives", 《INTERNATIONAL JOURNAL OF PHARMACEUTICS》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110507634A (zh) * | 2019-09-16 | 2019-11-29 | 湖北大学 | 一种电荷翻转型中空介孔硅基药物载体***及其制备方法 |
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CN109054010B (zh) | 2022-08-16 |
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Effective date of registration: 20200120 Address after: 110011 No. 53-4 Chaoyang Street, Shenhe District, Shenyang City, Liaoning Province, 7-5-3 Applicant after: Zhang Tianjiao Applicant after: Yang Yuwen Applicant after: Zhao Longshan Applicant after: Li Sanming Applicant after: Ma Hongda Address before: 110179 room 772, 155-5 innovation road, Hunnan District, Shenyang, Liaoning. Applicant before: SHENYANG SINDATECH PHARM Co.,Ltd. |
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Effective date of registration: 20220725 Address after: 110179 No. 153-10, Chuangxin Road, Hunnan District, Shenyang City, Liaoning Province (1 gate) Applicant after: SHENYANG SINDATECH PHARM Co.,Ltd. Address before: 110011 7-5-3, 53-4 Chaoyang Street, Shenhe District, Shenyang City, Liaoning Province Applicant before: Zhang Tianjiao Applicant before: Yang Yuwen Applicant before: Zhao Longshan Applicant before: Li Sanming Applicant before: Ma Hongda |
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