CN109045236A - A kind of Tibetan medicinal preparation and preparation method thereof for treating rheumatoid arthritis - Google Patents

Abstract

The invention discloses a kind of Tibetan medicinal preparation and preparation method thereof for treating rheumatoid arthritis, preparation is made of the raw material of following parts by weight content: too 1-5 parts of assistant, 8-12 parts of terminalia flesh, 3-7 parts of olibanum, 1-5 parts of natural salt, 8-12 parts of Herba Lycopodii, 8-12 parts of nutmeg, 7-13 parts of tsaoko, 8-12 parts of safflower, 7-13 parts of cardamom, 8-12 parts of cloves, 7-13 parts of calcareous tufa, 8-12 parts of emblic, 7-13 parts of terminaliae billericae,fructus, 3-7 parts of rhizoma polygonati, 3-7 parts of lucid asparagus, 3-7 parts of himalayan four-o'clock root, 3-7 parts of puncture vine, hiding Radix Ophiopogonis 3-7 parts, 8-12 parts of crab (system).The present invention supplements the deficiency of existing drug therapy, reasonable recipe, for the risk factor symptomatic treatment of rheumatoid arthritis, multiple target point, too many levels, whole modulation body, all medicines play adjusting three because of disorder altogether, have the effect of relieving convulsion and calming the nerves, clearing and activating the channels and collaterals, dispelling wind and eliminating dampness, dry yellow water, anti-inflammatory analgetic, cold dispelling stomach invigorating.Clinically there is good therapeutic effect to rheumatic arthritis, it is significant in efficacy, safe and reliable.

Description

A kind of Tibetan medicinal preparation and preparation method thereof for treating rheumatoid arthritis

Technical field

The invention belongs to Tibetan medicine technical fields, and in particular to a kind of preparation for the Tibetan medicinal preparation for treating rheumatoid arthritis Method.

Background technique

Tibetan medicine, it is with a long history, be live in Qinghai-Tibet Platean people and the Nature struggle in gradually recognize one A little substances derived from plant, animal and mineral can be used for disease treatment and health with certain pharmacological action；It is wide It is general to absorb, merged traditional Chinese medicine and pharmacy, on the basis of Indian Medicinal and big dietitian's pharmacy scheduling theory, pass through long-term practice formation Unique medicine systems are that China is more complete, one of the ethnic drug that influence power highlights.

Rheumatoid arthritis be it is a kind of regardless of cold and heat, the of all ages, disease that is likely to suffer from regardless of region, it is main The symptoms such as the enlargement of extremities joint symmetry pain, morning stiffness, deformity are shown as, though the death rate is lower, disability rate is higher, to life Living and work belt carrys out very big pain.

Rheumatoid arthritis category Tibetanmedicine " arthritis with fixed pain caused by dampness card " scope, transliteration are " chapter rash ".It is that yellow water gathers in articular cavity, closes Save a kind of disease based on the pain as crushing.Often in spring illness, autumn has set in breaking-out or winter illness, breaking-out that spring has set in.Tibetan medicine Think that the disease is to cause digest decomposition unclear because of territorial environment, diet discomfort, so as to cause caused by blood and yellow water confusion Disease is divided into six kinds of syndrome manifested as myalgia,numbness and flaccidity, heumatism, vessle-Bi symptom-complex, tendon numbness, white numbness, black numbness etc., wherein white numbness, symptoms include cold Sheng, it is mainly shown as Extremities joint enlargement, pain, it is stiff, even deform, weather turn cold after aggravate etc..

Treatment rheumatoid arthritis is mostly with Chinese medicine and Western medicine therapy at present.Though being to part patient with rheumatoid arthritis Effectively, but treatment method and drug are limited, and western medicine side effect is big, still have some patientss to control by Chinese medicine or Western medicine system Treatment does not improve, or improves unobvious.

Summary of the invention

The purpose of the present invention is to solve the technical problems existing in the prior art, a kind of reasonable recipe, curative effect are provided Significantly, the Tibetan medicinal preparation for the treatment of rheumatoid arthritis securely and reliably.

It is a further object to provide a kind of preparation methods of Tibetan medicinal preparation for treating rheumatoid arthritis.

In order to achieve the above object, the invention adopts the following technical scheme: a kind of Tibetan medicine for treating rheumatoid arthritis Preparation is made of the raw material of following parts by weight content: assistant too 1-5 parts, 8-12 parts of terminalia flesh, 3-7 parts of olibanum, 1-5 parts of natural salt, 8-12 parts of Herba Lycopodii, 8-12 parts of nutmeg, 7-13 parts of tsaoko, 8-12 parts of safflower, 7-13 parts of cardamom, 8-12 parts of cloves, calcareous tufa 7-13 parts, 8-12 parts of emblic, 7-13 parts of terminaliae billericae,fructus, 3-7 parts of rhizoma polygonati, 3-7 parts of lucid asparagus, 3-7 parts of himalayan four-o'clock root, puncture 3-7 parts of Chenopodiaceae, hiding Radix Ophiopogonis 3-7 parts, 8-12 parts of crab (system).

Further, a kind of Tibetan medicinal preparation for treating rheumatoid arthritis is made of the raw material of following parts by weight content: Assistant too 3 parts, 10 parts of terminalia flesh, 5 parts of olibanum, 3 parts of natural salt, 10 parts of Herba Lycopodii, 10 parts of nutmeg, 10 parts of tsaoko, 10 parts of safflower, 10 parts of cardamom, 10 parts of cloves, 10 parts of calcareous tufa, 10 parts of emblic, 10 parts of terminaliae billericae,fructus, 5 parts of rhizoma polygonati, 5 parts of lucid asparagus, Himalaya 5 parts of four-o'clock, 5 parts of puncture vine, hiding 5 parts of Radix Ophiopogonis, 10 parts of crab (system).

A kind of preparation method of Tibetan medicinal preparation that treating rheumatoid arthritis, method includes the following steps:

A, prepare bulk pharmaceutical chemicals: the pre-treatment principle by each raw material in formula according to Tibetan medicine to different cultivars ingredient requirement removes Non- medicinal effects and impurity reach the required standard of production；

B, it prepares fine powder: each bulk pharmaceutical chemicals after processing of step A is weighed according to the amount in formula, by terminalia flesh, olibanum, light Salt, Herba Lycopodii, nutmeg, tsaoko, safflower, cardamom, cloves, calcareous tufa, emblic, terminaliae billericae,fructus, rhizoma polygonati, lucid asparagus, happiness horse traction Refined four-o'clock, puncture vine, hiding Radix Ophiopogonis, crab (system) crush respectively and are sieved to obtain fine powder by high-efficiency screening machine；

C, it mixes: each fine powder being prepared is uniformly mixed with assistant too fine powder to get the Tibetan medicine for the treatment of rheumatoid arthritis Preparation.

Further, high-efficiency screening machine screen mesh is 100 mesh in the step B.

The present invention has the advantages that the Tibetan medicinal preparation of present invention treatment rheumatoid arthritis compared with the prior art It in accordance with ancient method sorting, processes, is formulated according to " Six-element, eight property, 17 effects " are theoretical, compound compatibility meets Tibetan medicine's theory characteristic and pass Key, by help too, terminalia flesh, olibanum, natural salt, Herba Lycopodii, nutmeg, tsaoko, safflower, cardamom, cloves, calcareous tufa, emblic, Totally ten nine taste Tibetan medicine materials form for terminaliae billericae,fructus, rhizoma polygonati, lucid asparagus, himalayan four-o'clock root, puncture vine, hiding Radix Ophiopogonis, crab (system), Fang Zhong Inverse, nutmeg middle benefit gas promoting the circulation of qi, cardamom promoting the circulation of qi middle benefit gas, safflower blood circulation, removing blood stasis and acesodyne drop in cloves middle benefit gas.It supplements existing medicine The deficiency of object treatment, reasonable recipe, for the risk factor symptomatic treatment of rheumatoid arthritis, multiple target point, too many levels, entirety Property adjust body, all medicines play adjusting three because of disorder altogether, and there is relieving convulsion and calming the nerves, clearing and activating the channels and collaterals, dispelling wind and eliminating dampness, dry yellow water, anti-inflammatory to stop Bitterly, the effect of cold dispelling stomach invigorating.Clinically there is good therapeutic effect to rheumatic arthritis, it is significant in efficacy, safe and reliable.

Specific embodiment

The present invention is further explained in the light of specific embodiments.

Embodiment 1

A kind of Tibetan medicinal preparation for treating rheumatoid arthritis, is made of the raw material of following weight content: assistant too 1g, terminalia flesh 12g, olibanum 3g, natural salt 5g, Herba Lycopodii 8g, nutmeg 12g, tsaoko 7g, safflower 12g, cardamom 7g, cloves 12g, calcareous tufa 7g, emblic 12g, terminaliae billericae,fructus 7g, rhizoma polygonati 7g, lucid asparagus 3g, himalayan four-o'clock root 7g, puncture vine 3g, hiding Radix Ophiopogonis 7g, crab (system) 8g.

Embodiment 2

A kind of Tibetan medicinal preparation for treating rheumatoid arthritis, is made of the raw material of following weight content: assistant too 5g, terminalia flesh 8g, olibanum 7g, natural salt 1g, Herba Lycopodii 12g, nutmeg 8g, tsaoko 13g, safflower 8g, cardamom 13g, cloves 8g, calcareous tufa 13g, emblic 8g, terminaliae billericae,fructus 13g, rhizoma polygonati 3g, lucid asparagus 7g, himalayan four-o'clock root 3g, puncture vine 7g, hiding Radix Ophiopogonis 3g, crab (system) 12g.

Embodiment 3

A kind of Tibetan medicinal preparation for treating rheumatoid arthritis, is made of the raw material of following weight content: assistant too 3g, terminalia flesh 10g, olibanum 5g, natural salt 3g, Herba Lycopodii 10g, nutmeg 10g, tsaoko 10g, safflower 10g, cardamom 10g, cloves 10g, lime Magnificent 10g, emblic 10g, terminaliae billericae,fructus 10g, rhizoma polygonati 5g, lucid asparagus 5g, himalayan four-o'clock root 5g, puncture vine 5g, hiding Radix Ophiopogonis 5g, crab Crab (system) 10g.

When being prepared to the Tibetan medicinal preparation of above-described embodiment, comprising the following steps:

A, prepare bulk pharmaceutical chemicals: the pre-treatment principle by each raw material in formula according to Tibetan medicine to different cultivars ingredient requirement removes Non- medicinal effects and impurity reach the required standard of production.

B, it prepares fine powder: each bulk pharmaceutical chemicals after processing of step A is weighed according to the amount in formula, by terminalia flesh, olibanum, light Bright salt, Herba Lycopodii, nutmeg, tsaoko, safflower, cardamom, cloves, calcareous tufa, emblic, terminaliae billericae,fructus, rhizoma polygonati, lucid asparagus, happiness horse Refined four-o'clock, puncture vine, hiding Radix Ophiopogonis, crab (system) is drawn to crush respectively and be sieved to obtain fine powder by high-efficiency screening machine, wherein efficiently The screen mesh of screening machine is 100 mesh.

C, it mixes: each fine powder being prepared is uniformly mixed with assistant too fine powder to get treatment rheumatoid arthritis Tibetan medicinal preparation.

The Tibetan medicinal preparation of above-described embodiment can use mixing in water for oral taking, and suitable quantity of water can also be added and be made into pill.

Clinical test:

One, case-data:

The foundation of preparation clinical research methods is that modern traditional Chinese and western medicine Clinical Study Protocol is combined according to Tibetan medicine and pharmacology theoretical system, according to Preparation target user, takes the course for the treatment of, it is determined that Clinical Study Protocol.Define inclusion criteria, the control drug, Bing Renji of case history It checks, therapeutic evaluation, adverse reaction etc., passes through after the inspection of plinth sign, the inspection of feature biochemical indicator, medication course, period and medication The validity of statistical analysis Scientific evaluation preparation.Altogether observe patient with rheumatoid arthritis 120, be randomly divided into treatment group and Control group each 60, male 18, female 42, the age 30-60 years old, average age 45 years old, average course of disease 5 years in treatment group.Control Male 16, female 44, the age 30-60 years old, average age 45 years old, average course of disease 5 years in group.Gender, age, the disease of 2 groups of patients The general information comparing difference such as journey is not statistically significant (P > 0.05), is comparable.

Two, diagnostic criteria:

Referring to the Western medicine diagnostic criteria of the rheumatoid arthritis of American Society of Rheumatism 1987 (RA classification standard): 1. morning stiffness is held It is 1 hour (daily), the course of disease at least 6 weeks continuous；2. having 3 or 3 or more swollen joints, at least 6 weeks；3. wrist, metacarpophalangeal, proximal end refer to pass Section is swollen, and at least 6 weeks；4. symmetry swollen joint at least 6 weeks；5. there is subcutaneous nodule；6. hand X-ray film changes (at least osteoporosis It is narrow with joint space)；7. serum rheumatoid factor (SRF) content increases；There are 4 persons in above-mentioned 7 that can be diagnosed as rheumatoid Property arthritis.

It is included in standard

It is included in: 1. meeting above-mentioned diagnostic criteria；2. there are no restrictions on age or sex；3. this treat before in January or during this treatment not Receive other methods curer；4. informed consent.

Exclusion criteria

It excludes: 1. not meeting above-mentioned diagnosis, is included in standard person；2. joint slippage person or fracture person；3. being closed caused by other reasons Save pain person；4. being mentally ill or history of drug abuse person.

Three, treatment method

Control group control group patient gives aceclofenac in extended-released tablets (Zhejiang Prov JianFeng Pharmaceutical Co., Ltd according to dosage.Approval text Number: the sub- H20090011 of national drug standard) and Nimesulide sustained-release tablet (authentication code state of HaiNan Kangzhi Pharmaceutical Co., Ltd The quasi- word H20090235 of medicine) Combined with Oral treatment, January is as a treatment course, carries out Comparison of therapeutic after 3 courses for the treatment of are used in conjunction.

Treatment group for the treatment of group patient gives Tibetan medicinal preparation made from the embodiment of the present invention 3, and to add suitable quantity of water that pill is made oral Treatment, every ball weight 1g, daily after early postprandial, lunch, after dinner, each taking 20 balls.One month is 1 course for the treatment of, and 3 treatments are used in conjunction Comparison of therapeutic is carried out after journey.

Four, criterion of therapeutical effect:

Referring to State Administration of Traditional Chinese Medicine " disease of tcm Standardization of diagnosis and curative effect " [2]: 1. cure: each portion's pain in joint disappears, and closes Section function is wholly or substantially restored；2. improving: each portion's pain relief in joint or disappearance, movable function improve；3. invalid: symptom without Improve.

Five, statistical method

Data processing carries out statistical analysis with spss13.0 software, and enumeration data uses X2 inspection, and (P ﹤ 0.05 is difference tool It is statistically significant).

Six, result

Treatment group and control group patient clinical curative effect are relatively shown in Table 1.

1: two group of patient clinical curative effect of table compares

Seven, overall merit:

By clinical test, treatment group's effect is substantially better than control group, reaches extremely significant difference, total effective rate is up to 95%, in clinic Symptom improves aspect, shows preferable efficient and cure rate, adverse reaction does not occur, demonstrates Tibetan medicine traditional medicine Science.

Claims (4)

1. a kind of Tibetan medicinal preparation for treating rheumatoid arthritis, it is characterised in that: be made of the raw material of following parts by weight content: Help too 1-5 parts, 8-12 parts of terminalia flesh, 3-7 parts of olibanum, 1-5 parts of natural salt, 8-12 parts of Herba Lycopodii, 8-12 parts of nutmeg, tsaoko 7- 13 parts, 8-12 parts of safflower, 7-13 parts of cardamom, 8-12 parts of cloves, 7-13 parts of calcareous tufa, 8-12 parts of emblic, 7-13 parts of terminaliae billericae,fructus, 3-7 parts of rhizoma polygonati, 3-7 parts of lucid asparagus, 3-7 parts of himalayan four-o'clock root, 3-7 parts of puncture vine, hiding Radix Ophiopogonis 3-7 parts, crab (system) 8-12 Part.

2. a kind of Tibetan medicinal preparation for treating rheumatoid arthritis according to claim 1, it is characterised in that: by following heavy Measure the raw material composition of part content: assistant too 3 parts, 10 parts of terminalia flesh, 5 parts of olibanum, 3 parts of natural salt, 10 parts of Herba Lycopodii, nutmeg 10 Part, 10 parts of tsaoko, 10 parts of safflower, 10 parts of cardamom, 10 parts of cloves, 10 parts of calcareous tufa, 10 parts of emblic, 10 parts of terminaliae billericae,fructus, rhizoma polygonati 5 Part, 5 parts of lucid asparagus, 5 parts of himalayan four-o'clock root, 5 parts of puncture vine, hiding 5 parts of Radix Ophiopogonis, 10 parts of crab (system).

3. a kind of preparation method for the Tibetan medicinal preparation for treating rheumatoid arthritis, it is characterised in that this method includes following step It is rapid:

A, prepare bulk pharmaceutical chemicals: the pre-treatment principle by each raw material in formula according to Tibetan medicine to different cultivars ingredient requirement removes Non- medicinal effects and impurity reach the required standard of production；

B, it prepares fine powder: each bulk pharmaceutical chemicals after processing of step A is weighed according to the amount in formula, by terminalia flesh, olibanum, light Salt, Herba Lycopodii, nutmeg, tsaoko, safflower, cardamom, cloves, calcareous tufa, emblic, terminaliae billericae,fructus, rhizoma polygonati, lucid asparagus, happiness horse traction Refined four-o'clock, puncture vine, hiding Radix Ophiopogonis, crab (system) crush respectively and are sieved to obtain fine powder by high-efficiency screening machine；

C, it mixes: each fine powder being prepared is uniformly mixed with assistant too fine powder to get the Tibetan medicine for the treatment of rheumatoid arthritis Preparation.

4. a kind of preparation method of Tibetan medicinal preparation for treating rheumatoid arthritis according to claim 3, feature exist In: high-efficiency screening machine screen mesh is 100 mesh in the step B.