CN109030099B - Liquid taking test method and device - Google Patents
Liquid taking test method and device Download PDFInfo
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- CN109030099B CN109030099B CN201810574701.4A CN201810574701A CN109030099B CN 109030099 B CN109030099 B CN 109030099B CN 201810574701 A CN201810574701 A CN 201810574701A CN 109030099 B CN109030099 B CN 109030099B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
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Abstract
The application provides a liquid taking testing method and device, and relates to the technical field of biological medical treatment. A liquid extraction test method comprising: acquiring measurement parameters of the probe in a primary liquid taking process, wherein the measurement parameters are parameters causing signal change of the probe; and determining whether the liquid taking in the primary liquid taking process is successful or not according to the variation and the judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the variation of the measurement parameter from the default liquid taking ending moment to the default liquid level leaving moment. By using the technical scheme of the application, the misjudgment rate of judging whether the liquid is successfully taken can be reduced.
Description
Technical Field
The invention relates to the field of biomedical treatment, in particular to a liquid taking testing method and device.
Background
In the biomedical field, various types of experiments are often required. During the course of the experiment, it was necessary to suck up the liquid from the liquid-holding container. Specifically, a probe for sucking liquid in the liquid sucking device is driven by a motor to move downwards or upwards in the liquid containing container. To prevent the probe from hitting the bottom of the liquid container and sucking unnecessary liquid, the probe sucks the liquid when the probe touches the liquid level of the liquid in the liquid container. After the probe sucks the liquid, the liquid is transferred to other containers and discharged.
In the actual operation of liquid suction, factors such as bubbles, static electricity, electromagnetic interference, distributed capacitance and the like often exist, so that the probe is judged to be contacted with the liquid level by mistake when not contacted with the liquid level, the liquid taking failure is judged to be successful by mistake, and the misjudgment rate of the liquid taking success is higher. At the present stage, in order to reduce the misjudgment rate of successful liquid taking, the liquid suction device records the position of the liquid level contacted by the probe each time. And judging whether the current probe is in contact with the liquid level or not by comparing the current probe position with the recorded last probe contact position on the liquid level. If the difference distance between the two positions exceeds a reasonable threshold value, the current probe is determined not to contact the liquid level, the liquid taking is not successful, and the misjudgment is generated. However, in a case where only one liquid extraction is required and a case where the liquid extraction is performed for the first time, since the probe does not come into contact with the liquid surface in the previous time, it is impossible to determine whether or not the current probe has succeeded in extracting the liquid, and the erroneous determination rate is still high.
Disclosure of Invention
The embodiment of the invention provides a liquid taking test method and device, which can reduce the misjudgment rate of judging whether liquid taking is successful or not.
In a first aspect, the present invention provides a liquid extraction testing method, comprising: acquiring measurement parameters of the probe in a primary liquid taking process, wherein the measurement parameters are parameters causing signal change of the probe; and determining whether the liquid taking in the primary liquid taking process is successful or not according to the variation and a judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the variation of the measurement parameter from the default liquid taking ending moment to the default liquid level leaving moment.
In a second aspect, the present invention provides a liquid taking test apparatus, comprising a liquid taking test circuit and a probe; the probe is used for taking liquid; the liquid taking test circuit is used for obtaining a measurement parameter of the probe in a one-time liquid taking process, and the measurement parameter is a parameter causing the signal change of the probe; and the device is used for determining whether the liquid taking in the primary liquid taking process is successful according to the variation and the judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the variation of the measurement parameter from the default liquid taking end time to the default liquid level leaving time.
The invention provides a liquid taking test method and a liquid taking test device, which are used for determining whether liquid taking is successful in the liquid taking process by utilizing the variable quantity and the judgment threshold value in the liquid taking process at one time. The variation in the liquid taking process comprises the variation of the measurement parameters from the default liquid taking end moment to the default liquid level leaving moment. In the scene that the probe is not contacted with the liquid level and is mistakenly judged to be contacted with the liquid level or the liquid taking amount of the probe is insufficient, the measurement parameter variation from the default liquid taking ending time to the time after the default liquid taking ending time is similar, and judgment can be carried out by utilizing the judgment threshold, so that the misjudgment is avoided, and the misjudgment rate of whether the probe is successful or not is reduced. The liquid taking test method in the embodiment of the invention can reduce the misjudgment rate of judging whether the liquid taking is successful or not in the scene only needing single liquid taking and the scene of first liquid taking.
Drawings
The present invention will be better understood from the following description of specific embodiments thereof taken in conjunction with the accompanying drawings, in which like or similar reference characters designate like or similar features.
FIG. 1 is a schematic diagram of an application scenario according to an embodiment of the present invention;
FIG. 2 is a schematic diagram showing a relationship between oscillation frequency and time of a probe signal during a liquid extraction process according to an embodiment of the present invention;
FIG. 3 is a diagram illustrating a relationship between a variation of an oscillation frequency of a probe signal during a liquid extraction process and time according to an embodiment of the present invention;
FIG. 4 is a graph showing the variation of the oscillation frequency of the probe signal with respect to time during the liquid extraction process according to another embodiment of the present invention;
FIG. 5 is a graph showing the variation of the oscillation frequency of the probe signal with respect to time during the liquid extraction process according to another embodiment of the present invention;
FIG. 6 is a flow chart of a fluid extraction testing method according to an embodiment of the present disclosure;
FIG. 7 is a diagram illustrating a variation of an oscillation frequency versus time according to an embodiment of the present invention;
FIG. 8 is a graph illustrating variation of oscillation frequency of noise with time according to an embodiment of the present invention;
FIG. 9 is a schematic structural diagram of a liquid sampling testing apparatus according to an embodiment of the present disclosure;
fig. 10 is a schematic hardware structure diagram of a liquid extraction device in an embodiment of the present invention.
Detailed Description
Features and exemplary embodiments of various aspects of the present invention will be described in detail below. In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the present invention by illustrating examples of the present invention. The present invention is in no way limited to any specific configuration and algorithm set forth below, but rather covers any modification, replacement or improvement of elements, components or algorithms without departing from the spirit of the invention. In the drawings and the following description, well-known structures and techniques are not shown in order to avoid unnecessarily obscuring the present invention.
References in the present application to "one embodiment," "an embodiment," "various embodiments," "an example," etc., indicate that the embodiment(s) or example(s) described may include a particular feature, structure, or characteristic, but every embodiment or example need not necessarily include the particular feature, structure, or characteristic. Moreover, repeated usage of the phrase "in one example" does not necessarily refer to the same example, although it may.
The liquid taking test method, the liquid taking test device, the liquid taking equipment and the storage medium provided by the embodiment of the invention can be applied to scenes in which liquid is required to be taken for experiments or experiments in the fields of biology, medicine, chemistry, physics and the like. Fig. 1 is a schematic view of an application scenario in an embodiment of the present invention. As shown in fig. 1, the probe of the liquid taking test device moves up and down under the control of the liquid taking test circuit, and sucks the liquid in the liquid container (i.e., the liquid taking). And in the process of liquid taking, the probe gradually descends from the upper part of the liquid until a part of the probe is immersed in the liquid, and the probe stops moving to take the liquid. When the preset liquid taking time is reached or the quantity of the obtained liquid reaches a preset quantity, the probe finishes liquid taking and gradually rises until the position of the probe is reset to the position when the liquid taking process is started.
In the liquid taking process, the liquid taking testing device can judge whether the probe contacts the liquid level according to the change of the probe signal. In the process that the probe does not contact the liquid level, the probe always moves in a certain medium (air in the embodiment of the invention), and the signal of the probe has no change or has small change. After the probe contacts the liquid surface and before the probe leaves the liquid surface, the head of the probe stays or moves in a certain medium (which can be liquid in the embodiment of the invention), and the signal of the probe has no change or has small change.
During the process from the probe never contacting the liquid surface to the probe contacting the liquid surface, the probe signal suddenly changes greatly (i.e. changes suddenly) to generate large fluctuation due to the head of the probe entering from one medium (air in the embodiment of the present invention) to another medium (liquid in the embodiment of the present invention). However, due to the influence of external factors, such as air bubbles, static electricity, electromagnetic interference, distributed capacitance, etc., the probe signal may suddenly change greatly (i.e., suddenly change), resulting in large fluctuation. Under the influence of external factors, the probe is not contacted with the liquid level, and the probe is possibly mistakenly judged to be contacted with the liquid level. After the misjudgment occurs, the probe starts to take liquid under the condition that the probe does not contact the liquid level, so that the liquid taking fails. Or, the distance of the probe entering the liquid level is not matched with the preset liquid taking amount, so that the probe is separated from the liquid level in the liquid taking process, and the liquid taking is insufficient. Insufficient liquid extraction is an embodiment of liquid extraction failure.
In one example, the mutation in the probe signal can be embodied as a mutation in the oscillation frequency of the probe signal. For example, fig. 2 is a graph illustrating the relationship between the oscillation frequency of the probe signal and time in the liquid extraction process according to an embodiment of the present invention. As shown in fig. 2, noise is taken as an external factor. Noise can cause the oscillation frequency to suddenly change. The probe enters the liquid from air and the probe enters the liquid from air, which causes the oscillation frequency to change suddenly. Therefore, noise and success of probe draw during draw are difficult to distinguish.
FIG. 3 is a diagram illustrating a relationship between a variation of an oscillation frequency of a probe signal during a liquid extraction process and time according to an embodiment of the present invention. As shown in fig. 3, in the course of one successful liquid extraction, when the probe contacts the liquid surface, the change amount of the oscillation frequency of the probe signal changes abruptly. And in the process that the probe enters the liquid level and takes the liquid, the variation of the oscillation frequency of the probe signal is gradually reduced until the oscillation frequency returns to zero. When the probe leaves the liquid surface, the amount of change in the oscillation frequency of the probe signal changes abruptly again. And in the process of rising and resetting the probe away from the liquid level, the variation of the oscillation frequency of the probe signal is gradually reduced until the oscillation frequency returns to zero.
FIG. 4 is a graph illustrating the variation of the oscillation frequency of the probe signal with time during the liquid sampling process according to another embodiment of the present invention. As shown in fig. 4, if the probe successfully takes the liquid, the EG section is the stage of the probe base liquid level; the GH section is a stage of taking liquid by a probe; the HI section is the stage where probe draw successfully exits the liquid. However, if the probe draw does not reach the standard amount, it is removed from the liquid level, and as can be seen from FIG. 4, a sudden change in the amount of change in the oscillation frequency occurs in the GH section (i.e., before the HI section) where the amount of change in the oscillation frequency does not suddenly change.
FIG. 5 is a graph showing the variation of the oscillation frequency of the probe signal with respect to time during the liquid extraction process according to another embodiment of the present invention. As shown in fig. 5, if the probe successfully takes the liquid, the EG section is the stage of the probe base liquid level; the GH section is a stage of taking liquid by a probe; the HI section is the stage where probe draw successfully exits the liquid. However, if the oscillation frequency of the probe signal is affected by external factors such as noise, the amount of change in the oscillation frequency of the probe signal changes abruptly even when the probe does not contact the liquid surface. Or, if the time for taking the liquid by the probe is too short, the oscillation frequency of the probe signal is not recovered in the process from the end of taking the liquid by the probe to the separation of the probe from the liquid surface, so that the variation of the oscillation frequency of the probe signal in the process from the end of taking the liquid by the probe to the separation of the probe from the liquid surface is small. As can be seen from fig. 5, however, in the HI section, the amount of change in the oscillation frequency does not change abruptly.
According to the liquid taking test method, the liquid taking test device, the liquid taking equipment and the storage medium, whether liquid taking succeeds in the liquid taking process is determined according to the variable quantity and the judgment threshold of the measurement parameters in the primary liquid taking process. Whether the liquid extraction is successful or not in the liquid extraction process can be judged more accurately, so that the misjudgment of the successful liquid extraction is avoided, and the misjudgment rate of the successful liquid extraction judgment is reduced. It should be noted that "mutation" in the following examples means that the measured parameter increases or decreases by a value exceeding a threshold value over a period of time.
Fig. 6 is a flowchart of a liquid extraction testing method according to an embodiment of the present invention. As shown in fig. 6, the liquid extraction test method includes steps S101 to S102.
In step S101, measurement parameters of the probe in one liquid extraction process are acquired.
Wherein the measured parameter is a parameter that causes a change in the signal of the probe. Such as one or more of capacitance, resistance, inductance, pressure, oscillation frequency of the probe signal. In the process that the probe enters liquid from air, the capacitance, the resistance, the inductance and the pressure of the probe all generate mutation, and the mutation of the capacitance, the resistance, the inductance and the pressure of the probe can be embodied as the mutation of the oscillation frequency of a probe signal. To facilitate the recording of observations and determinations, the oscillation frequency of the probe signal can be monitored and acquired. For example, the change of the capacitance value of the probe relative to the ground can be converted into the oscillation frequency of the probe signal which is easier to monitor or the charge-discharge time in the oscillation period of the probe signal according to the RC oscillator principle, and the capacitance is inversely proportional to the oscillation frequency. For another example, the change in the capacitance value of the probe with respect to ground can be converted into an oscillation frequency of the probe signal or a charge/discharge time in an oscillation cycle of the probe signal, which is easier to monitor, according to the LC oscillator principle.
The probe obtains measurement parameters for many times in the process of one-time liquid taking. In one example, the period for acquiring the measurement parameter may be set, for example, the period for acquiring the measurement parameter is set to 10 milliseconds, and the liquid taking test device acquires the measurement parameter every 10 milliseconds during the liquid taking process.
In step S102, it is determined whether the liquid extraction in the primary liquid extraction process is successful according to the variation of the measurement parameter in the primary liquid extraction process and the determination threshold.
In the process of one-time liquid taking, the difference value of the measurement parameters at any two moments is the variation of the measurement parameters at the two moments. The variation in the one-time liquid taking process comprises the variation of the measurement parameters from the default liquid taking end moment to the default liquid level leaving moment. The determination threshold is used to assist in determining whether the liquid extraction is successful in the liquid extraction process, and may be specifically set according to a working scenario and a working requirement, which is not limited herein.
The default liquid extraction completion time is the default time for completing liquid extraction by the probe. During one liquid taking process, when the measurement parameter changes suddenly for the first time, the default probe contacts the liquid level, but actually, whether the probe contacts the liquid level cannot be determined at this time. The probe is controlled to draw fluid at or after the default probe contacts the fluid level. And recording the moment when the liquid taking time length reaches the preset liquid taking time length as the default liquid taking finishing moment. The default meniscus-leaving time is any time the default probe is in a meniscus-leaving state. When the measured parameter changes abruptly for the second time, the default probe is moved away from the liquid level. In the primary liquid taking process, any one of the moment when the measurement parameter changes suddenly for the second time and the time period after the measurement parameter changes suddenly for the second time can be recorded as the default liquid level leaving moment. For example, in the process of liquid extraction once, after the liquid extraction is finished, the probe moves upwards to leave the liquid level until the probe returns to the reset position, and the reset position is the position where the probe is located when the liquid extraction process is started. The time at which the probe returns to the reset position may be taken as the default time to leave the liquid level.
In one example, the decision threshold comprises a change amount threshold. The variation threshold is a threshold set for the variation, and may be specifically set according to a working scene and a working requirement, and is not limited herein.
The variation of the measurement parameter at the default liquid taking end moment and the variation of the measurement parameter at the default liquid level leaving moment can be obtained. And if the variation of the measurement parameter at the default liquid taking ending moment and the measurement parameter at the default liquid level leaving moment is larger than or equal to the variation threshold, determining that the liquid taking is successful. And if the variation of the measurement parameter at the default liquid taking ending moment and the measurement parameter at the default liquid level leaving moment is smaller than the variation threshold, determining that the liquid taking fails.
For example, the measurement parameter is the oscillation frequency of the probe signal. The variation threshold is 0.019MHz (megahertz). The oscillation frequency of the acquired probe signal at the default liquid taking end time is 3.956MHz, and the variation of the measurement parameter at the default liquid level leaving time is 3.976 MHz. The liquid taking is determined to be successful because 3.976MHz-3.956MHz is more than 0.019 MHz. And if the oscillation frequency of the acquired probe signal at the default liquid taking end time is 3.974MHz, the variation of the measurement parameter at the default liquid level leaving time is 3.976 MHz. And determining that the liquid extraction fails because 3.976MHz-3.974MHz is less than 0.019 MHz.
The variation of the measurement parameter at the default liquid taking end moment and the measurement parameter at the default liquid level leaving moment is larger than or equal to the variation threshold, which indicates that the measurement parameter changes suddenly from the default liquid taking end moment to the default liquid level leaving moment. And the variation of the measurement parameter at the default liquid taking ending moment and the measurement parameter at the default liquid level leaving moment is smaller than the variation threshold, which indicates that the measurement parameters do not have mutation from the default liquid taking ending moment to the default liquid level leaving moment.
If the liquid is successfully taken in the liquid taking process, the head of the probe is still in the liquid at the default liquid taking end time, and the head of the probe is in the air at the default liquid level leaving time. At the moment the probe head leaves the liquid level, the measurement parameters are subjected to sudden changes.
On the contrary, if the liquid extraction fails in the liquid extraction process, the duration of the sudden change caused by the influence of external factors on the contact liquid level of the misjudgment probe is short, the head of the probe is already in the air at the default liquid extraction ending moment, and the head of the probe is also in the air at the default liquid level leaving moment. No mutation occurred in the measured parameters.
Therefore, whether the liquid level is contacted by the probe in the liquid taking process is judged by mistake or not can be determined through the relation between the variation and the variation threshold of the measurement parameter at the default liquid taking finishing moment and the measurement parameter at the default liquid level leaving moment, so that whether the liquid taking is successful or not can be accurately judged, the misjudgment is avoided, and the misjudgment rate of the successful liquid taking judgment is reduced.
In another example, the decision threshold comprises an integral error adjustment threshold. The integral error adjustment threshold is an error threshold set for integral of the variation, and may be specifically set according to a working scene and a working requirement, and is not limited herein.
The integral of the first relation function of the variation of the measurement parameter from the default liquid taking end moment to the default liquid level leaving moment and the time can be obtained. And the integral of the second relation function of the variation of the measurement parameter from the default liquid level non-contact time to the default liquid level contact time to the time can be obtained.
The description of the default liquid-taking end time and the default liquid-leaving time may refer to the related description part in the above embodiments, and will not be described herein again.
The default non-contact time is the time when the probe has not contacted the liquid surface. The default contact level time is the default probe head entry into the liquid level. In the process of one liquid taking, when the measurement parameters are mutated for the first time, the default probe is contacted with the liquid level. It should be noted that any time in the period of time before the default probe contacts the liquid level may be regarded as the default non-contact time. The default contact level time may be the default time at which the head of the probe enters the liquid level. Any time in the period from the time when the default probe contacts the liquid level to the time when the default probe finishes liquid extraction can be regarded as the default liquid level contact time. For example, in a single liquid taking process, any time in a period from the first time of mutation of the measurement parameter to the second time of mutation of the measurement parameter can be regarded as the default liquid level contact time.
Specifically, the first relation function and the second relation function may be represented in the form of a relation curve. For example, taking the measurement parameter as the oscillation frequency of the probe signal as an example, fig. 7 is a graph illustrating a variation of the oscillation frequency with respect to time according to an embodiment of the present invention. As shown in fig. 7, the area of a graph a1 (i.e., a shaded portion a1) enclosed by the relationship curve corresponding to the first relationship function and the straight line with the ordinate of 0 is the integral of the first relationship function. As shown in fig. 7, the second relation function corresponds to a relation curve that is substantially located on the negative half axis of the ordinate, so that the integral of the second relation function is negative. That is, the inverse of the area of the graph a2 (i.e., the shaded portion a2) surrounded by the relationship curve corresponding to the second relationship function and the straight line having the ordinate 0 is the integral of the second relationship function.
In the present example, as shown in fig. 7, the area of the shaded portion a1 and the area of the shaded portion a2 can be used to determine whether or not the liquid extraction was successful. Correspondingly, the inverse number of the integral of the first relation function and the integral of the second relation function is used for determining whether the liquid extraction is successful.
And if the difference value between the integral of the first relation function and the integral error adjusting threshold is less than or equal to the inverse number of the integral of the second relation function, and the sum of the integral of the first relation function and the integral error adjusting threshold is greater than or equal to the inverse number of the integral of the second relation function, determining that the liquid extraction is successful. And if the difference value between the integral of the first relation function and the integral error adjusting threshold is greater than the inverse number of the integral of the second relation function, or the sum of the integral of the first relation function and the integral error adjusting threshold is less than the inverse number of the integral of the second relation function, determining that the liquid extraction fails.
For example, the measurement parameter is the oscillation frequency of the probe signal. The integral of the first relation function is an integral of a relation function of a change amount of the oscillation frequency of the probe signal from the liquid extraction end time to the default liquid level leaving time with respect to time. The integral of the second relation function is the integral of the relation function of the variation of the measured parameter from the moment of the default liquid level non-contact to the moment of the default liquid level contact and the time. The integral error adjustment threshold is 0.05 MHz. The integral of the acquired first relation function is 1.79 MHz. The integral of the obtained second relation function is-1.80 MHz. The success of liquid extraction is determined because 1.79MHz-0.05MHz < 1.80MHz < 1.79MHz +0.05 MHz. The integral of the acquired first relation function is 0.57 MHz. The integral of the obtained second relation function is-1.80 MHz. Since 0.57MHz +0.05MHz < 1.80MHz, the fluid draw was determined to have failed.
The difference between the integral of the first relation function and the integral error adjustment threshold is less than or equal to the inverse of the integral of the second relation function, and the sum of the integral of the first relation function and the integral error adjustment threshold is greater than or equal to the inverse of the integral of the second relation function. I.e. the integral of the first relation function is similar to the inverse of the integral of the second relation function. The change quantity of the measurement parameters from the default liquid taking end moment to the default liquid level leaving moment and the change quantity of the measurement parameters from the default liquid level non-contact moment to the default liquid level contact moment are all mutated, and the mutated amplitudes are similar. That is, the probe completes the action of entering the liquid from the air in the period from the time of not contacting the liquid level by default to the time of contacting the liquid level by default. And in the time period from the default liquid taking end moment to the default liquid level leaving moment, the probe finishes the action of separating liquid from the liquid into air. It can be determined that the draw was successful.
The difference between the integral of the first relation function and the integral error adjustment threshold is greater than the inverse of the integral of the second relation function, or the sum of the integral of the first relation function and the integral error adjustment threshold is less than the inverse of the integral of the second relation function. The change of the measurement parameter is only subjected to one sudden change in the time period from the default liquid-level non-contact time to the default liquid-level contact time and in the time period from the default liquid-taking end time to the default liquid-level leaving time. That is, the probe does not complete the action of entering liquid from air during the time period from the time of default non-contact with the liquid level to the time of default contact with the liquid level. Or the probe does not finish the action of separating the liquid from the air in the time period from the default liquid taking end time to the default liquid level leaving time. The fluid extraction is determined to have failed.
Therefore, whether the liquid level contacted by the probe in the liquid taking process is judged by mistake can be determined through the relation between the integral of the first relation function, the inverse number of the integral of the second relation function and the integral error adjusting threshold value, so that whether the liquid taking is successful can be accurately judged, the misjudgment is avoided, and the misjudgment rate of judging whether the liquid taking is successful is reduced.
For example, fig. 8 is a graph illustrating a variation of the oscillation frequency of the noise according to the embodiment of the present invention. As shown in fig. 8, noise appears from the default liquid-withdrawal completion time to the default liquid-level-leaving time, and the change amount of the oscillation frequency changes abruptly. Specifically, the variation of the oscillation frequency is abruptly increased first, and then the variation of the oscillation frequency is abruptly decreased next. Then it is determined whether the tapping was successful or not using the integral of the first relationship function, the integral of the second relationship function, and the integral error adjustment threshold in the above example. Wherein the integral of the first relation function is the sum of the area of the shaded portion B1 and the inverse of the area of the shaded portion B2. As can be seen from fig. 8, the area of the shaded portion B2 is larger than the area of the shaded portion B1, and the integral of the first relational function is a negative number, and the sum of the integral of the first relational function and the integral error adjustment threshold is smaller than the inverse number of the integral of the second relational function, and it is determined that the liquid extraction has failed. Therefore, the situation that the liquid taking is influenced by the noise and is not successful can be accurately judged in the scene where the noise appears.
In the embodiment of the invention, whether the liquid extraction is successful in the liquid extraction process is determined by using the variable quantity and the judgment threshold value in the liquid extraction process at one time. The variation in the liquid taking process comprises the variation of the measurement parameters from the default liquid taking end moment to the default liquid level leaving moment. The main reasons for misjudging the liquid taking failure as the liquid taking success include that the probe does not contact the liquid level and is misjudged as the probe contacts the liquid level, or the probe does not take the liquid enough, so that the head of the probe is separated from the liquid when the liquid taking of the probe is finished. In the scene that the probe does not contact the liquid level and is mistakenly judged to be the probe contact liquid level or the probe liquid taking is insufficient, the measurement parameter variation from the default liquid taking end time to the time after the default liquid taking end time is similar, and judgment can be carried out by utilizing the judgment threshold, so that the misjudgment is avoided, and the misjudgment rate of judging whether the probe successfully takes the liquid is reduced. The liquid taking test method in the embodiment of the invention is suitable for scenes only needing single liquid taking, scenes only needing initial liquid taking and other scenes, and can reduce the misjudgment rate of judging whether the probe successfully takes the liquid. Moreover, on the basis of reducing the misjudgment rate of judging whether the probe successfully takes the liquid, the embodiment of the invention does not influence the time occupied by the liquid taking process, and does not add a device in the liquid taking test device, namely does not increase the complexity of the liquid taking test device.
In one example, the default liquid level leaving time may be any time in a time period after the default liquid taking end time when the variation of the measurement parameter is continuously zero. After the default liquid extraction completion time, the probe gradually rises. If the probe has a certain depth in the liquid, the probe needs a period of time after the default liquid taking end moment, and the probe can be separated from the liquid. After the probe is separated from the liquid, the probe continuously rises until reset. During the process of the ascending and resetting of the probe, the variation of the measured parameter is gradually reduced until the variation is zero. After the default liquid-taking end time, at any time in a period of time in which the amount of change in the measurement parameter continues to be zero, it can be determined that the probe has left the liquid level. The integral of the first relation function obtained by the method is more accurate, so that the accuracy of judging whether the liquid extraction is successful can be further improved, and the misjudgment rate of judging whether the liquid extraction is successful is reduced.
In one example, the default liquid-level-contacting time may be selected as any time in a period of time during which the amount of change in the measurement parameter continues to be zero after the absolute value of the amount of change in the measurement parameter is first greater than the change threshold and before the absolute value of the amount of change in the measurement parameter is second greater than the change threshold. The change threshold is a threshold value for determining whether the change amount of the measurement parameter changes suddenly, and may be set according to a working scenario and a working requirement, which is not limited herein. After the probe contacts the liquid surface, the probe may continue to descend a distance and begin to draw liquid. And in the process that the probe descends after contacting the liquid level and takes the liquid, the variation of the measurement parameter is gradually reduced until the variation is zero. The probe may be determined to have entered the liquid during a time period when the amount of change in the measured parameter is zero after the default non-contact liquid level time. The integral of the second relation function obtained by the method is more accurate, so that the accuracy of judging whether the liquid extraction is successful can be further improved, and the misjudgment rate of judging whether the liquid extraction is successful is reduced.
Fig. 9 is a schematic structural diagram of a liquid extraction testing device according to an embodiment of the present invention. As shown in fig. 9, the liquid extraction test apparatus includes a probe 21 and a liquid extraction test circuit 22.
Wherein the probe 21 is used for taking the liquid.
The liquid taking test circuit 22 is used for obtaining a measurement parameter of the probe in a liquid taking process at one time, wherein the measurement parameter is a parameter causing the signal change of the probe; and the liquid level detection device is used for determining whether liquid taking in the primary liquid taking process is successful or not according to the variation and the judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the variation of the measurement parameter from the default liquid taking end time to the default liquid level leaving time.
Specifically, the determination threshold includes a variation threshold. In one example, the draw test circuit 22 includes a probing module 221. The detection module 221 is configured to determine that liquid extraction is successful when a variation between the measurement parameter at the default liquid extraction end time and the measurement parameter at the default liquid level leaving time is greater than or equal to a variation threshold. The detection module 221 is further configured to determine that liquid fetching fails when a variation between the measurement parameter at the default liquid fetching end time and the measurement parameter at the default liquid level leaving time is smaller than a variation threshold.
Specifically, the variation in the primary liquid taking process further includes the variation of the measurement parameter from the moment when the liquid level is not contacted to the moment when the liquid level is contacted; the decision threshold comprises an integral error adjustment threshold. In one example, the draw test circuit 22 includes a probing module 221. The detection module 221 is configured to obtain an integral of a first relation function between a variation of the measurement parameter from a default liquid-taking end time to a default liquid-level-leaving time and time. The detection module 221 is further configured to obtain an integral of a second relation function of a variation of the measurement parameter from a default non-liquid-level contact time to a default liquid-level contact time with time. The detection module 221 is further configured to determine that the liquid extraction is successful when a difference between the integral of the first relation function and the integral error adjustment threshold is less than or equal to an inverse of the integral of the second relation function, and a sum of the integral of the first relation function and the integral error adjustment threshold is greater than or equal to an inverse of the integral of the second relation function. The detection module 221 is further configured to determine that the liquid extraction fails when a difference between the integral of the first relation function and the integral error adjustment threshold is greater than an inverse of the integral of the second relation function, or a sum of the integral of the first relation function and the integral error adjustment threshold is less than an inverse of the integral of the second relation function.
In one example, the default liquid level leaving time is any time in a time period after the default liquid level taking end time, wherein the variation of the measurement parameter is continuously zero.
In one example, the above-mentioned default liquid-level-contacting timing is any timing in a period of time during which the amount of change in the measurement parameter continues to be zero after the absolute value of the amount of change in the measurement parameter is first greater than the change threshold and before the absolute value of the amount of change in the measurement parameter is second greater than the change threshold after the default liquid-level-non-contacting timing is the default liquid-level-non-contacting timing.
In one example, the measurement parameter may include one or more of capacitance, resistance, inductance, pressure, and oscillation frequency of the probe signal, which is not limited herein.
It should be noted that the liquid taking test circuit may further include a signal processing module 222, a conversion module 223, a conditioning module 224, and a control module 225.
Wherein, an external power supply 23 can be arranged to supply power for the liquid taking testing device. The conditioning module 224 can convert the basic measurement parameters of the probe relative to the ground, such as capacitance, resistance, inductance, pressure, etc., into the oscillation frequency of the probe signal or the charge-discharge time in the oscillation cycle of the probe signal, which is easy to measure, and input the oscillation frequency or the charge-discharge time to the conversion module 223 in the form of an analog signal. The conversion module 223 converts the analog signal into a digital signal. The digital signal is further filtered by the signal processing module 222. The detection module 221 may determine whether the liquid extraction is successful according to the filtered digital signal. The detection module 221 may be further configured to generate and send a success notification message or a failure notification message when it is determined that the liquid extraction is successful or failed. The control module 225 may control the movement, stopping, and extraction of the probe. The above modules may also be implemented by more modules or fewer modules through functional integration or functional division, and are not limited herein.
In one example, the probe 21 may be a double-layer probe. The inner layer of the double-layer probe 21 is connected with the liquid taking test circuit 22, and specifically, the inner layer of the double-layer probe 21 can be connected with the conditioning module 224 in the liquid taking test circuit 22. The outer layer of the bi-layer probe is connected to a reference ground. The reference ground is an internal ground isolated from the power supply. That is, the reference ground is isolated from the power ground. The core of the liquid taking test device 20, namely the liquid taking test circuit 22, is isolated from other equipment or components, and the adverse effect of interference signals brought by other equipment or components on the liquid taking test process is prevented. Therefore, the accuracy of judging whether the liquid extraction is successful is further improved, and the misjudgment rate of judging whether the liquid extraction is successful is reduced.
The embodiment of the invention also provides a liquid taking system, which comprises the liquid taking testing device and a tray 31 for placing a liquid container. Wherein the tray 31 is connected to a reference ground. Specifically, the tray 31 may be a metal tray.
In one example, the insulating layer 32 and the instrument rack 33 may be further stacked in order downward below the tray 31. The instrument rack is connected to a power ground. In particular, the instrument rack may be a metal rack. The insulating layer 32 serves to isolate the tray 31 from the instrument housing 33.
The tray 31 is connected to a reference ground with both outer layers of the bi-layer probe. The instrument frame is connected with a power ground. The reference ground is isolated from the power ground. Therefore, the core of the liquid taking test device 20, namely the liquid taking test circuit 22, is further isolated from peripheral equipment, such as an instrument frame and the like, in the liquid taking system, and the adverse effect of interference signals brought by the peripheral equipment on the liquid taking test process is prevented. Therefore, the accuracy of judging whether the liquid extraction is successful is further improved, and the misjudgment rate of judging whether the liquid extraction is successful is reduced.
The specific functions and advantages of the liquid extraction testing device can be found in the detailed description of the liquid extraction testing method in the above embodiments, and are not repeated herein.
The liquid extraction testing method and apparatus according to various embodiments of the present invention described in connection with fig. 1 to 9 may be implemented by a liquid extraction device 400. Fig. 10 is a schematic hardware structure diagram of a liquid extraction apparatus 400 according to an embodiment of the present invention.
The tapping device 400 comprises a probe (not shown in fig. 10), a memory 401 and a processor 402. The memory 401 has stored thereon a program that is executable on the processor 402. The program runs on the processor 402 to implement the fluid extraction test method in the above-described embodiment.
In one example, the processor 402 may include a Central Processing Unit (CPU), or an Application Specific Integrated Circuit (ASIC), or may be configured to implement one or more integrated circuits of embodiments of the present application.
Memory 401 may include mass storage for data or instructions. By way of example, and not limitation, memory 401 may include an HDD, floppy disk drive, flash memory, optical disk, magneto-optical disk, magnetic tape, or Universal Serial Bus (USB) drive, or a combination of two or more of these. Memory 401 may include removable or non-removable (or fixed) media, where appropriate. The reservoir 401 may be internal or external to the tapping device 400, where appropriate. In a particular embodiment, the memory 401 is a non-volatile solid-state memory. In a particular embodiment, the memory 401 includes Read Only Memory (ROM). Where appropriate, the ROM may be mask-programmed ROM, Programmable ROM (PROM), Erasable PROM (EPROM), Electrically Erasable PROM (EEPROM), electrically rewritable ROM (EAROM), or flash memory or a combination of two or more of these.
The processor 402 runs a program corresponding to the executable program code by reading the executable program code stored in the memory 401, for executing the liquid taking test method in each of the above embodiments.
In one example, the fluid extraction device 400 can also include a communication interface 403 and a bus 404. As shown in fig. 10, the memory 401, the processor 402, and the communication interface 403 are connected by a bus 404 to complete mutual communication.
The communication interface 403 is mainly used for implementing communication between modules, apparatuses, units and/or devices in the embodiments of the present application. The communication interface 403 may also access input devices and/or output devices.
Bus 404 comprises hardware, software, or both that couple the components of fluid-withdrawal device 400 to one another. By way of example, and not limitation, the bus 404 may include an Accelerated Graphics Port (AGP) or other graphics bus, an Enhanced Industry Standard Architecture (EISA) bus, a Front Side Bus (FSB), a Hyper Transport (HT) interconnect, an Industry Standard Architecture (ISA) bus, an infiniband interconnect, a Low Pin Count (LPC) bus, a memory bus, a Micro Channel Architecture (MCA) bus, a Peripheral Component Interconnect (PCI) bus, a PCI-Express (PCI-X) bus, a Serial Advanced Technology Attachment (SATA) bus, a video electronics standards association local (VLB) bus, or other suitable bus, or a combination of two or more of these. Bus 404 may include one or more buses, where appropriate. Although specific buses are described and shown in the embodiments of the application, any suitable buses or interconnects are contemplated by the application.
An embodiment of the present invention further provides a storage medium, where the storage medium stores a program, and the program, when executed by a processor, can implement the liquid taking test method in each of the above embodiments.
All parts of the specification are described in a progressive mode, the same and similar parts of all embodiments can be referred to each other, and each embodiment is mainly introduced to be different from other embodiments. In particular, apparatus embodiments, device embodiments, and storage medium embodiments are substantially similar to method embodiments and therefore are described in a relatively simple manner with reference to the description of the method embodiments.
The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present disclosure, and all the changes or substitutions should be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (7)
1. A liquid extraction testing method is characterized by comprising the following steps:
acquiring measurement parameters of the probe in a primary liquid taking process, wherein the measurement parameters are parameters causing signal change of the probe;
determining whether liquid taking in the primary liquid taking process is successful or not according to the variation and a judgment threshold of the measurement parameter in the primary liquid taking process, wherein the variation in the primary liquid taking process comprises the variation of the measurement parameter from a default liquid taking end time to a default liquid level leaving time, and the default liquid taking end time is the time when the liquid taking time reaches a preset liquid taking time;
the variation in the primary liquid taking process further comprises the variation of the measurement parameters from the moment when the liquid level is not contacted to the moment when the liquid level is contacted to the default; the decision threshold comprises an integral error adjustment threshold; the default liquid level contact time is the time within the time period from the time when the probe contacts the liquid level to the time when the default liquid taking is finished;
the determining whether the liquid extraction in the primary liquid extraction process is successful according to the variation and the judgment threshold of the measurement parameter in the primary liquid extraction process includes:
acquiring the integral of a first relation function of the variation of the measurement parameter from the default liquid taking end moment to the default liquid level leaving moment and the time;
acquiring the integral of a second relation function of the variation of the measurement parameter from the moment of the default liquid surface not being contacted to the moment of the default liquid surface being contacted with the liquid surface and the time;
and if the difference value between the integral of the first relation function and the integral error adjusting threshold is less than or equal to the inverse number of the integral of the second relation function, and the sum of the integral of the first relation function and the integral error adjusting threshold is greater than or equal to the inverse number of the integral of the second relation function, determining that the liquid extraction is successful.
2. The method of claim 1, wherein a fluid extraction failure is determined if the difference between the integral of the first relationship function and the integral error adjustment threshold is greater than the inverse of the integral of the second relationship function, or the sum of the integral of the first relationship function and the integral error adjustment threshold is less than the inverse of the integral of the second relationship function.
3. The method according to any one of claims 1 to 2, wherein the measured parameter comprises one or more of capacitance, resistance, inductance, pressure, oscillation frequency of the probe signal.
4. A liquid taking test device is characterized by comprising a liquid taking test circuit and a probe;
the probe is used for taking liquid;
the liquid taking test circuit is used for obtaining a measurement parameter of the probe in a one-time liquid taking process, and the measurement parameter is a parameter causing the signal change of the probe; the device comprises a measuring parameter acquisition unit, a liquid level acquisition unit and a liquid level acquisition unit, wherein the measuring parameter acquisition unit is used for acquiring a liquid level of a liquid level in the liquid level acquisition unit, and the liquid level acquisition unit is used for acquiring a liquid level in the liquid level acquisition unit;
the variation in the primary liquid taking process further comprises the variation of the measurement parameters from the moment when the liquid level is not contacted to the moment when the liquid level is contacted to the default; the decision threshold comprises an integral error adjustment threshold; the default liquid level contact time is the time within the time period from the time when the probe contacts the liquid level to the time when the default liquid taking is finished;
the liquid taking test circuit comprises a detection module, and the detection module is used for:
acquiring the integral of a first relation function of the variation of the measurement parameter from the default liquid taking end moment to the default liquid level leaving moment and the time;
acquiring the integral of a second relation function of the variation of the measurement parameter from the moment of the default liquid surface not being contacted to the moment of the default liquid surface being contacted with the liquid surface and the time;
and determining that the liquid extraction is successful when the difference between the integral of the first relation function and the integral error adjustment threshold is less than or equal to the inverse number of the integral of the second relation function, and the sum of the integral of the first relation function and the integral error adjustment threshold is greater than or equal to the inverse number of the integral of the second relation function.
5. The apparatus of claim 4, wherein the detection module is further configured to determine that the fluid extraction has failed if the difference between the integral of the first relationship function and the integral error adjustment threshold is greater than the inverse of the integral of the second relationship function, or the sum of the integral of the first relationship function and the integral error adjustment threshold is less than the inverse of the integral of the second relationship function.
6. The apparatus of any one of claims 4 to 5, wherein the measured parameter comprises one or more of capacitance, resistance, inductance, pressure, oscillation frequency of the probe signal.
7. The apparatus of claim 4, wherein the probe is a double layer probe, wherein an inner layer of the double layer probe is connected to the liquid draw test circuit and an outer layer of the double layer probe is connected to a reference ground, the reference ground being isolated from a power ground.
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