CN109009182B - Method for realizing serial imaging of optoacoustic and other modes and registration device - Google Patents
Method for realizing serial imaging of optoacoustic and other modes and registration device Download PDFInfo
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- 238000003384 imaging method Methods 0.000 title claims abstract description 69
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- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
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- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 238000003672 processing method Methods 0.000 claims description 4
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 3
- 238000002600 positron emission tomography Methods 0.000 claims description 3
- 238000003325 tomography Methods 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 230000008878 coupling Effects 0.000 abstract description 6
- 238000010168 coupling process Methods 0.000 abstract description 6
- 238000005859 coupling reaction Methods 0.000 abstract description 6
- 230000001575 pathological effect Effects 0.000 abstract description 4
- 230000000241 respiratory effect Effects 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 230000008859 change Effects 0.000 description 2
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A61B6/5247—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
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Abstract
The invention provides a method for realizing serial imaging of optoacoustic and other modes and a registration device. The registration device is provided with the photoacoustic bracket, the sleeve, the breathing mask and the other-mode bracket, and ensures that the measured object keeps the same body position during photoacoustic imaging and other-mode imaging on the premise of not changing a photoacoustic and other-mode imaging system, so that multi-mode image information of the same fault is acquired, and serial imaging of the photoacoustic and other modes is realized. Meanwhile, the breathing mask is provided with a waterproof sealing ring, so that the photoacoustic coupling film can be removed during photoacoustic imaging, artifacts caused by the photoacoustic coupling film are avoided, and the quality of photoacoustic imaging is improved. According to the method, the same tomographic image information is acquired through the registration device, and the image information of multiple modes is fused together, so that richer tissue structure function information is obtained, and further research on tissue physiological and pathological state changes is facilitated.
Description
Technical Field
The invention relates to the technical field of multi-mode imaging, in particular to a method for realizing serial imaging of photoacoustic and other modes and a registration device.
Background
Photoacoustic imaging is a new biomedical imaging method developed in recent years, both non-invasive and non-ionizing. The photoacoustic imaging combines the advantages of high selectivity in pure optical tissue imaging and deep penetration in pure ultrasonic tissue imaging, tissue images with high resolution and high contrast can be obtained, the amount of information transmitted by photoacoustic signals is large, and morphological and functional information can be provided. In recent years, photoacoustic imaging technology has been rapidly developed, and is mainly applied to the fields of tumor detection, blood vessel imaging and the like. However, the single imaging technology provides limited biological information, and cannot obtain more abundant structural and functional information, thereby limiting further research on changes of tissue physiological and pathological states.
Therefore, it is necessary to provide a method and a registration apparatus for implementing serial photoacoustic and other modalities to overcome the above-mentioned deficiencies in the prior art.
Disclosure of Invention
One of the purposes of the invention is to provide a method for realizing serial imaging of photoacoustic and other modalities, wherein a measured object can keep the same body position when in photoacoustic imaging and other modality imaging through the registration device, so that serial imaging of photoacoustic and other modalities is realized, and a photoacoustic image and an image of other modality of the same fault are obtained.
The above object of the present invention is achieved by the following technical means.
A method for realizing serial photoacoustic and other modality imaging is provided, and the same body position of a measured object is kept during photoacoustic imaging and other modality imaging by using a registration device, so that a photoacoustic and other modality serial image of the same fault is obtained.
Preferably, the other modality imaging is any one of X-ray tomography, magnetic resonance imaging and positron emission tomography; the photoacoustic image acquisition uses the same layer thickness and step size as other modality image acquisitions.
Further, by means of image processing, photoacoustic of the same fault and other modality serial image information are fused together.
Further, the registration device is provided with a photoacoustic bracket, a sleeve, a breathing mask and other modal brackets;
the photoacoustic bracket comprises a mounting plate, a left cantilever and a right cantilever, and the sleeve comprises a left sleeve and a right sleeve;
the mounting plate is fixed on the photoacoustic device, the left cantilever is fixed at the left end of the mounting plate, the right cantilever is fixed at the right end of the mounting plate, the left sleeve is fixed at the bottom end of the left cantilever, and the right sleeve is fixed at the bottom end of the right cantilever;
the breathing mask is assembled inside the left sleeve or the right sleeve, and the modal support of the breathing mask is fixed at the bottoms of the left sleeve and the right sleeve.
Furthermore, the breathing mask comprises a mask main body and a mask bayonet, wherein the mask main body comprises a cylindrical breathing port and a conical nipple which are smoothly connected, and the mask bayonet is clamped on the outer surface of the conical nipple; the cylindrical breathing port is connected with an external oxygen input port, and the conical sleeve mouth is used for fixing the head of the measured object.
Further, the inner surface of the conical sleeve mouth is provided with a flat groove, and the flat groove is used for placing the chin of the measured object; the edge of the conical sleeve nozzle is provided with a waterproof sealing ring; the junction of the columnar breathing port and the conical sleeve mouth is provided with a copper wire, and the copper wire is used for placing teeth of the tested object.
Further, waterproof sealing washer is the waterproof sealing washer of silica gel.
Further, the left sleeve comprises a left outer sleeve and a left inner sleeve, the right sleeve comprises a right outer sleeve and a right inner sleeve, the left inner sleeve is slidably assembled inside the left outer sleeve, and the right inner sleeve is slidably assembled inside the right outer sleeve.
Further, the left outer sleeve and the right outer sleeve are both provided with screw holes for fixing limbs of the measured object; a groove is formed in the middle of the modal support and used for enabling the abdomen of the tested object to be suspended.
The method for realizing the serial imaging of the photoacoustic modality and the other modalities ensures that the measured object keeps the same body position during the photoacoustic imaging and the other modalities through the registration device, thereby acquiring the information of the same tomographic image, then fuses the information of the images of the multiple modalities of the same tomographic image through an image processing method, and adds the structural information of the images of the other modalities into the photoacoustic image for guiding reconstruction, thereby obtaining richer tissue structure function information and being beneficial to the further research on the change of the tissue physiological and pathological states.
Another object of the present invention is to provide a registration apparatus for implementing serial imaging of photoacoustic and other modalities, which is configured as the registration apparatus of the above structure.
The registration device for realizing serial imaging of the photoacoustic modality and the other modality ensures that the measured object keeps the same body position during the photoacoustic imaging and the other modality imaging on the premise of not changing the photoacoustic and other modality imaging system, thereby acquiring multi-mode image information of the same fault and realizing the serial imaging of the photoacoustic modality and the other modality; meanwhile, the registration device is provided with a waterproof breathing mask, so that the photoacoustic coupling film can be removed during photoacoustic imaging, artifacts caused by the photoacoustic coupling film are avoided, and the quality of photoacoustic imaging is improved.
Drawings
The invention is further illustrated by means of the attached drawings, the content of which is not in any way limitative of the invention.
FIG. 1 is a schematic diagram of the structure of the method for implementing serial photoacoustic imaging and other modalities according to the present invention;
FIG. 2 is a schematic diagram of the construction of a photoacoustic mount of the present invention;
FIG. 3 is a schematic view of the construction of a respiratory mask of the present invention;
FIG. 4 is an exploded view of the respiratory mask of the present invention;
FIG. 5 is an exploded view of the sleeve of the present invention;
FIG. 6 is a schematic structural view of an alternative modal support of the present invention;
fig. 7 is a flow chart illustrating a method for implementing serial photoacoustic imaging and other modalities according to the present invention.
Fig. 1 to 6, including: the photoacoustic stent 1, the mounting plate 11, the left cantilever 12, the right cantilever 13, the sleeve 2, the left sleeve 21, the left outer sleeve 211, the left inner sleeve 212, the right sleeve 22, the right outer sleeve 221, the right inner sleeve 222, the respiratory mask 3, the mask body 31, the cylindrical respiratory orifice 311, the conical nipple 312, the flat groove 3121, the waterproof sealing ring 3122, the copper wire 3123, the mask bayonet 32, the other-mode stent 4 and the groove 41.
Detailed Description
The invention is further described with reference to the following examples.
Example 1.
As shown in fig. 1-6, a registration apparatus for implementing serial photoacoustic and other modality imaging is provided with a photoacoustic mount 1, a sleeve 2, a respiratory mask 3 and an other modality mount 4;
the photoacoustic bracket 1 comprises a mounting plate 11, a left cantilever 12 and a right cantilever 13, and the sleeve 2 comprises a left sleeve 21 and a right sleeve 22;
the mounting plate 11 is fixed on the photoacoustic device, the left cantilever 12 is fixed at the left end of the mounting plate 11, the right cantilever 13 is fixed at the right end of the mounting plate 11, the left sleeve 21 is fixed at the bottom end of the left cantilever 12, and the right sleeve 22 is fixed at the bottom end of the right cantilever 13;
the breathing mask 3 is fitted inside the left sleeve 21 or inside the right sleeve 22 and the modal support 4 is fixed to the bottom of the left and right sleeves 21, 22.
The breathing mask 3 comprises a mask body 31 and a mask bayonet 32, wherein the mask body 31 comprises a cylindrical breathing port 311 and a conical nipple 312 which are smoothly connected, and the mask bayonet 32 is clamped on the outer surface of the conical nipple 312; the cylindrical breathing port 311 is connected with an external oxygen input port, and the conical nipple 312 is used for fixing the head of the tested object. The use of respirator can prevent to be surveyed the object motion for being surveyed the object and keeping the same position in carrying out optoacoustic imaging and other modal imaging processes, realize the image information acquisition of same fault, respirator can prevent to be surveyed the respiratory organ contact water of object simultaneously, and accessible cylindricality breathing mouth lets in anesthesia and oxygen and supplies to be surveyed the object breathing.
The inner surface of the conical nipple 312 is provided with a flat groove 3121, the flat groove 3121 is used for placing the chin of the measured object, and the edge of the conical nipple 312 is provided with a waterproof sealing ring 3122, so that the face of the measured object is tightly attached to the waterproof sealing ring. The copper wire 3123 is arranged at the joint of the cylindrical breathing opening 311 and the conical sleeve mouth 312, and the copper wire 3123 is used for placing the teeth of the tested object to prevent the tested object from biting the tongue.
The left sleeve 21 includes a left outer sleeve 211 and a left inner sleeve 212, the right sleeve 22 includes a right outer sleeve 221 and a right inner sleeve 222, the left inner sleeve 212 is slidably fitted inside the left outer sleeve 211, the right inner sleeve 222 is slidably fitted inside the right outer sleeve 221, and the left and right inner sleeves are horizontally slidable left and right to adjust the imaging area.
The left outer sleeve 211 and the right outer sleeve 221 are provided with screw holes for fixing limbs of the object to be measured. The specific implementation mode is as follows: the limbs of the tested object are bound through one end of the rope, the screw is screwed in the screw hole, and the other end of the rope is fixed on the screw.
A groove 41 is formed in the middle of the modal support 4, and the groove 41 is used for enabling the abdomen of the tested object to be suspended and preventing the abdomen of the tested object from deforming to influence the image acquisition result.
The method for realizing serial imaging of photoacoustic and other modalities of the embodiment ensures that the object to be measured keeps the same body position during photoacoustic imaging and other modality imaging on the premise of not changing a photoacoustic and other modality imaging system, so that multi-modality image information of the same fault is acquired, and serial imaging of photoacoustic and other modalities is realized.
Example 2.
The present embodiment provides a registration apparatus for implementing photoacoustic and other modality serial imaging, which has the same other features as embodiment 1, except that: waterproof sealing ring 3122 is silica gel waterproof sealing ring 3122.
According to the method for realizing serial imaging of photoacoustic and other modalities, the breathing mask is provided with the silica gel waterproof sealing ring, the photoacoustic coupling film can be removed during photoacoustic imaging, artifacts caused by the photoacoustic coupling film are avoided, and the quality of photoacoustic imaging is improved.
Example 3.
In the method for implementing photoacoustic and other-modality serial imaging based on the registration apparatus in embodiment 1 or embodiment 2, as shown in fig. 7, by using the registration apparatus in embodiment 1 or embodiment 2, the measured object is kept in the same body position when photoacoustic imaging and other-modality imaging are performed, so that a photoacoustic and other-modality serial image of the same fault is obtained.
The other modality imaging is any one of X-ray tomography, magnetic resonance imaging and positron emission tomography; the photoacoustic image acquisition uses the same layer thickness and step size as other modality image acquisitions. By the image processing method, the photoacoustic of the same fault and the serial image information of other modes are fused together.
In the method for realizing serial photoacoustic and other modality imaging, the registration device enables the measured object to keep the same body position during photoacoustic imaging and other modality imaging, so that the same tomographic image information is acquired, then the image processing method fuses the image information of multiple modalities of the same tomographic layer, and the structure information of other modality images is added into the photoacoustic image for guiding reconstruction, so that richer tissue structure function information is obtained, and further study on tissue physiological and pathological state change is facilitated.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A method for realizing serial imaging of photoacoustic and other modalities is characterized in that a measured object keeps the same body position when in photoacoustic imaging and other modalities through a registration device, so that serial images of photoacoustic and other modalities of the same fault are obtained;
the registration device is provided with a photoacoustic bracket, a sleeve, a breathing mask and other modal brackets;
the photoacoustic bracket comprises a mounting plate, a left cantilever and a right cantilever, and the sleeve comprises a left sleeve and a right sleeve;
the mounting plate is fixed on the photoacoustic device, the left cantilever is fixed at the left end of the mounting plate, the right cantilever is fixed at the right end of the mounting plate, the left sleeve is fixed at the bottom end of the left cantilever, and the right sleeve is fixed at the bottom end of the right cantilever;
the breathing mask is assembled inside the left sleeve or the right sleeve, and the modal support of the breathing mask is fixed at the bottoms of the left sleeve and the right sleeve.
2. The method of claim 1, wherein the other modality imaging is any one of X-ray tomography, magnetic resonance imaging, and positron emission tomography; the photoacoustic image acquisition uses the same layer thickness and step size as other modality image acquisitions.
3. The method of claim 2, wherein the photoacoustic and other-modality serial image information of the same slice is fused together by the image processing method.
4. The method of enabling photoacoustic and other-modality serial imaging according to claim 3,
the breathing mask comprises a mask body and a mask bayonet, wherein the mask body comprises a cylindrical breathing opening and a conical nipple which are smoothly connected, and the mask bayonet is clamped on the outer surface of the conical nipple; the cylindrical breathing port is connected with an external oxygen input port, and the conical sleeve mouth is used for fixing the head of the measured object.
5. A method for performing photoacoustic and other modality serial imaging according to claim 4, wherein the inner surface of the conical nipple is provided with a flat groove for placing the chin of the measured object.
6. A method of performing photoacoustic and other modality serial imaging according to claim 5, wherein the rim of the tapered nipple is provided with a waterproof sealing ring; and a copper wire is arranged at the joint of the cylindrical breathing port and the conical sleeve mouth and used for placing teeth of the tested object.
7. The method of claim 6, wherein the waterproof sealing ring is a silicone waterproof sealing ring.
8. A method of performing photoacoustic and other modality serial imaging according to claim 7, wherein the left sleeve comprises a left outer sleeve and a left inner sleeve, and the right sleeve comprises a right outer sleeve and a right inner sleeve, the left inner sleeve being slidably fitted inside the left outer sleeve, and the right inner sleeve being slidably fitted inside the right outer sleeve.
9. The method for realizing serial photoacoustic and other modality imaging according to claim 8, wherein the left outer sleeve and the right outer sleeve are both provided with screw holes for fixing limbs of a measured object; a groove is formed in the middle of the other modal support and used for enabling the abdomen of the tested object to be suspended.
10. A registration apparatus for implementing serial photoacoustic imaging with other modalities, which is characterized by being a registration apparatus using the method for implementing serial photoacoustic imaging with other modalities according to any one of claims 1 to 9.
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EP1610672B1 (en) * | 2003-04-03 | 2009-03-11 | Siemens Medical Solutions USA, Inc. | Real-time acquisition of co-registered x-ray and optical images |
WO2012067607A1 (en) * | 2010-11-16 | 2012-05-24 | Analogic Corporation | Multi-modality image acquisition |
CN103735251A (en) * | 2014-01-14 | 2014-04-23 | 中国科学院自动化研究所 | Multi-modal optical imaging system |
CN104517293A (en) * | 2014-12-25 | 2015-04-15 | 东南大学 | Multimodal medical small animal image registration and fusion system |
CN106124469A (en) * | 2016-06-27 | 2016-11-16 | 中国科学院自动化研究所 | A kind of photoacoustic imaging and optical imagery multi-modal fusion imaging system |
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Publication number | Priority date | Publication date | Assignee | Title |
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EP1610672B1 (en) * | 2003-04-03 | 2009-03-11 | Siemens Medical Solutions USA, Inc. | Real-time acquisition of co-registered x-ray and optical images |
WO2012067607A1 (en) * | 2010-11-16 | 2012-05-24 | Analogic Corporation | Multi-modality image acquisition |
CN103735251A (en) * | 2014-01-14 | 2014-04-23 | 中国科学院自动化研究所 | Multi-modal optical imaging system |
CN104517293A (en) * | 2014-12-25 | 2015-04-15 | 东南大学 | Multimodal medical small animal image registration and fusion system |
CN106124469A (en) * | 2016-06-27 | 2016-11-16 | 中国科学院自动化研究所 | A kind of photoacoustic imaging and optical imagery multi-modal fusion imaging system |
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