CN109009182A - A kind of method and registration apparatus for realizing that optoacoustic and his mode are serially imaged - Google Patents

A kind of method and registration apparatus for realizing that optoacoustic and his mode are serially imaged Download PDF

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Publication number
CN109009182A
CN109009182A CN201810583179.6A CN201810583179A CN109009182A CN 109009182 A CN109009182 A CN 109009182A CN 201810583179 A CN201810583179 A CN 201810583179A CN 109009182 A CN109009182 A CN 109009182A
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optoacoustic
sleeve
mode
realizing
bracket
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CN109009182B (en
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戚力
张双阳
黄诗娴
理喜盼
刘嘉明
冯前进
陈武凡
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Southern Medical University
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Southern Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/04Positioning of patients; Tiltable beds or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0035Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/44Constructional features of apparatus for radiation diagnosis
    • A61B6/4417Constructional features of apparatus for radiation diagnosis related to combined acquisition of different diagnostic modalities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5247Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound

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  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Optics & Photonics (AREA)
  • Acoustics & Sound (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

The invention proposes a kind of methods and registration apparatus for realizing that optoacoustic and his mode are serially imaged.Registration apparatus is provided with optoacoustic bracket, sleeve, breathing mask and his mode bracket, under the premise of not changing optoacoustic and his modality imaging system, ensure that measurand keeps identical position in photoacoustic imaging and his modality, to collect the multi-modality images information of identical tomography, the serial imaging of optoacoustic Yu his mode is realized.Breathing mask is provided with waterproof grommet simultaneously, and photon-phonon coupling film can be removed in photoacoustic imaging, avoid photon-phonon coupling film bring artifact, improve the quality of photoacoustic imaging.This method collects same faultage image information by registration apparatus, together by multiple modalities image information fusion, to obtain institutional framework functional information more abundant, is conducive to the further research of tissue physiology's pathological state variation.

Description

A kind of method and registration apparatus for realizing that optoacoustic and his mode are serially imaged
Technical field
The present invention relates to multi-modality imaging technical field more particularly to a kind of sides for realizing optoacoustic and his mode and being serially imaged Method and registration apparatus.
Background technique
Photoacoustic imaging is the new bio medical imaging side of a kind of non-invasive and unionized formula developed in recent years Method.Photoacoustic imaging combines in the imaging of pure optical texture the excellent of deep penetration characteristic in high selection characteristic and the imaging of pure ultrasonic tissue Point, can be obtained the organization chart picture of high-resolution and high contrast, and photoacoustic signal transmitting contains much information, can provide form and Functional information.In recent years, photoacoustic imaging technology is rapidly developed, and is mainly used in the fields such as lesion detection, blood vessel imaging.But It is that the Biont information that single imaging technique provides is limited, structure function information more abundant cannot be obtained, limit group Knit the further research of physio-pathological condition variation.
Therefore, insufficient for the above-mentioned prior art, a kind of method and match for realizing that optoacoustic is serially imaged with his mode is provided Standard apparatus is very necessary with overcome the deficiencies in the prior art.
Summary of the invention
An object of the present invention provides a kind of method realizing optoacoustic and his mode and being serially imaged, and measurand passes through The registration apparatus is able to maintain identical position in photoacoustic imaging and when his modality, to realize the serial of optoacoustic and his mode Imaging obtains the photoacoustic image and his modality images of identical tomography.
Above-mentioned purpose of the invention is realized by following technological means.
A kind of method realizing optoacoustic and his mode and being serially imaged is provided, realizes that measurand exists by using registration apparatus Identical position is kept when photoacoustic imaging and his modality, to obtain the optoacoustic and the serial image of his mode of identical tomography.
Preferably, his modality is x-ray tomography imaging, magnetic resonance imaging, in positron emission tomography Any one;Photoacoustic image acquisition uses identical thickness and step-length with his modality images acquisition.
Further, by the method for image procossing, the optoacoustic of identical tomography is merged with his mode serial image information Together.
Further, registration apparatus is provided with optoacoustic bracket, sleeve, breathing mask and his mode bracket;
Optoacoustic bracket includes mounting plate, left cantilever and right cantilever, and sleeve includes left sleeve and right sleeve;
Mounting plate is fixed on optoacoustic equipment, and left cantilever is fixed on mounting plate left end, and right cantilever is fixed on mounting plate right end, left Sleeve is fixed on the bottom end of left cantilever, and right sleeve is fixed on the bottom end of right cantilever;
Breathing mask is assemblied in inside left sleeve or right sleeve inner, his mode bracket is fixed on left sleeve and right sleeve Bottom.
Further, breathing mask includes mask body and mask bayonet, and mask body includes that the cylindricality being smoothly connected is exhaled Suction inlet and taper sheath mouth, mask bayonet are fastened in taper sheath mouth outer surface;Cylindricality pneumostome is connect with external oxygen input port, cone Shape set mouth is for fixing measurand head.
Further, the inner surface of taper sheath mouth, which is provided with, rises as high as the banks, the chin risen as high as the banks for placing measurand;Taper sheath The edge of mouth is provided with waterproof grommet;The junction of cylindricality pneumostome and taper sheath mouth is provided with copper wire, and copper wire is for placing The tooth of measurand.
Further, waterproof grommet is silica gel waterproof grommet.
Further, left sleeve includes left outside sleeve and left inside sleeve, and right sleeve includes right outer sleeve and right inner sleeve, a left side Inner sleeve is slidably assemblied in left outside sleeve inner, and right inner sleeve is slidably assemblied in inside right outer sleeve.
Further, left outside sleeve and right outer sleeve are provided with screw hole, and screw hole is for fixing the four of measurand Limb;The middle position setting of his mode bracket is fluted, and groove is for keeping measurand abdomen hanging.
The method that realization optoacoustic and his mode of the invention is serially imaged, makes measurand in optoacoustic by registration apparatus Identical position is kept when imaging and his modality, to collect same faultage image information, then passes through image procossing Method his structural information of modality images together by the multiple modalities image information fusion of same tomography is added to light Reconstruction is guided in acoustic image, to obtain institutional framework functional information more abundant, is conducive to tissue physiology's pathology shape The further research of state variation.
Another object of the present invention provides a kind of registration apparatus realizing optoacoustic and his mode and being serially imaged, registration dress Install the registration apparatus for being set to above structure.
The registration apparatus that realization optoacoustic of the invention and his mode are serially imaged is not changing optoacoustic and his modality system Under the premise of system, it is ensured that measurand keeps identical position in photoacoustic imaging and his modality, to collect phase With the multi-modality images information of tomography, the serial imaging of optoacoustic Yu his mode is realized;Simultaneous Registration device is provided with waterproof and exhales Mask is inhaled, photon-phonon coupling film can be removed in photoacoustic imaging, avoid photon-phonon coupling film bring artifact, improve photoacoustic imaging Quality.
Detailed description of the invention
Using attached drawing, the present invention will be further described, but the content in attached drawing does not constitute any limitation of the invention.
Fig. 1 is the method structural schematic diagram that realization optoacoustic and his mode of the invention are serially imaged;
Fig. 2 is the structural schematic diagram of optoacoustic bracket of the invention;
Fig. 3 is the structural schematic diagram of breathing mask of the invention;
Fig. 4 is the structural decomposition diagram of breathing mask of the invention;
Fig. 5 is the structural decomposition diagram of sleeve of the invention;
Fig. 6 is the structural schematic diagram of his mode bracket of the invention;
Fig. 7 is the method flow schematic diagram that realization optoacoustic and his mode of the invention are serially imaged.
Fig. 1 to Fig. 6, comprising: optoacoustic bracket 1, mounting plate 11, left cantilever 12, right cantilever 13, sleeve 2, left sleeve 21, a left side Outer sleeve 211, left inside sleeve 212, right sleeve 22, right outer sleeve 221, right inner sleeve 222, breathing mask 3, mask body 31, Cylindricality pneumostome 311, taper sheath mouth 312,3121, waterproof grommet 3122 of rising as high as the banks, copper wire 3123, mask bayonet 32, his mode Bracket 4, groove 41.
Specific embodiment
The invention will be further described with the following Examples.
Embodiment 1.
As shown in figures 1 to 6, a kind of registration apparatus realizing optoacoustic and his mode and being serially imaged, is provided with optoacoustic bracket 1, set Cylinder 2, breathing mask 3 and his mode bracket 4;
Optoacoustic bracket 1 includes mounting plate 11, left cantilever 12 and right cantilever 13, and sleeve 2 includes left sleeve 21 and right sleeve 22;
Mounting plate 11 is fixed on optoacoustic equipment, and left cantilever 12 is fixed on 11 left end of mounting plate, and right cantilever 13 is fixed on installation 11 right end of plate, left sleeve 21 are fixed on the bottom end of left cantilever 12, and right sleeve 22 is fixed on the bottom end of right cantilever 13;
Breathing mask 3 is assemblied in inside 21 inside of left sleeve or right sleeve 22, his mode bracket 4 is fixed on 21 He of left sleeve The bottom of right sleeve 22.
Breathing mask 3 includes mask body 31 and mask bayonet 32, and mask body 31 includes the cylindricality breathing being smoothly connected Mouth 311 and taper sheath mouth 312, mask bayonet 32 are fastened in 312 outer surface of taper sheath mouth;Cylindricality pneumostome 311 and external oxygen Input port connection, taper sheath mouth 312 is for fixing measurand head.The use of breathing mask can prevent measurand from transporting Dynamic, measurand keeps identical position during allowing to carry out photoacoustic imaging and his modality, realizes the image of same tomography Information collection, while breathing mask can prevent the respiratory apparatus of measurand from contacting water, and anesthesia can be passed through by cylindricality pneumostome It is breathed with oxygen for measurand.
The inner surface of taper sheath mouth 312, which is provided with, rises as high as the banks 3121, rises as high as the banks 3121 for placing the chin of measurand, taper The edge of set mouth 312 is provided with waterproof grommet 3122, so that the face of measurand is close to waterproof grommet.Cylindricality pneumostome 311 and the junction of taper sheath mouth 312 be provided with copper wire 3123, copper wire 3123 is used to place the tooth of measurand, prevent by Object is surveyed to bite tongue.
Left sleeve 21 includes left outside sleeve 211 and left inside sleeve 212, and right sleeve 22 includes right outer sleeve 221 and right inner sleeve Cylinder 222, left inside sleeve 212 is slidably assemblied in inside left outside sleeve 211, and right inner sleeve 222 is slidably assemblied in right outer sleeve Inside 221, left and right inner sleeve can horizontally slip to adjust imaging region in the horizontal direction.
Left outside sleeve 211 and right outer sleeve 221 are provided with screw hole, and screw hole is used to fix the four limbs of measurand. Specific embodiment are as follows: bind the four limbs of measurand by one end of rope, screw on screw, the other end of rope in screw hole It is fixed on screw.
The middle position setting fluted 41 of his mode bracket 4, groove 41 for keeping measurand abdomen hanging, prevent by Surveying the deformation of object abdomen influences the result of Image Acquisition.
The method that the realization optoacoustic of the present embodiment and his mode are serially imaged is not changing optoacoustic and his modality imaging system Under the premise of, it is ensured that measurand keeps identical position in photoacoustic imaging and his modality, to collect identical The multi-modality images information of tomography realizes the serial imaging of optoacoustic Yu his mode.
Embodiment 2.
A kind of registration apparatus realizing optoacoustic and his mode and being serially imaged provided in this embodiment, other feature and embodiment 1 is identical, the difference is that: waterproof grommet 3122 is silica gel waterproof grommet 3122.
The method that the realization optoacoustic of the present embodiment and his mode are serially imaged, breathing mask are provided with silica gel waterproof sealing Photon-phonon coupling film can be removed in photoacoustic imaging, avoid photon-phonon coupling film bring artifact, improve the matter of photoacoustic imaging for circle Amount.
Embodiment 3.
A kind of realization optoacoustic based on the registration apparatus in embodiment 1 or embodiment 2 provided in this embodiment and his mode The method being serially imaged, as shown in fig. 7, realizing measurand in light by using the registration apparatus in embodiment 1 or embodiment 2 Identical position is kept when acoustic imaging and his modality, to obtain the optoacoustic and the serial image of his mode of identical tomography.
His modality is x-ray tomography imaging, magnetic resonance imaging, any one in positron emission tomography Kind;Photoacoustic image acquisition uses identical thickness and step-length with his modality images acquisition.It, will be identical by the method for image procossing The optoacoustic of tomography is fused together with his mode serial image information.
The method that the realization optoacoustic of the present embodiment and his mode are serially imaged, makes measurand in light by registration apparatus Identical position is kept when acoustic imaging and his modality, so that same faultage image information is collected, then by image His structural information of modality images together by the multiple modalities image information fusion of same tomography is added to by the method for reason Reconstruction is guided in photoacoustic image, to obtain institutional framework functional information more abundant, is conducive to tissue physiology's pathology The further research of state change.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention The limitation of range, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should be managed Solution, can with modification or equivalent replacement of the technical solution of the present invention are made, without departing from technical solution of the present invention essence and Range.

Claims (10)

1. a kind of method realizing optoacoustic and his mode and being serially imaged, which is characterized in that realized by using registration apparatus tested Object keeps identical position in photoacoustic imaging and his modality, to obtain the optoacoustic and his mode serialization graph of identical tomography Picture.
2. the method according to claim 1 realizing optoacoustic and his mode and being serially imaged, which is characterized in that his mode It is imaged as x-ray tomography imaging, magnetic resonance imaging, any one in positron emission tomography;Photoacoustic image acquisition Identical thickness and step-length are used with his modality images acquisition.
3. the method according to claim 2 realizing optoacoustic and his mode and being serially imaged, which is characterized in that at image The optoacoustic of identical tomography and his mode serial image information are fused together by the method for reason.
4. the method according to claim 3 realizing optoacoustic and his mode and being serially imaged, which is characterized in that the registration dress It installs and is equipped with optoacoustic bracket, sleeve, breathing mask and his mode bracket;
The optoacoustic bracket includes mounting plate, left cantilever and right cantilever, and sleeve includes left sleeve and right sleeve;
The mounting plate is fixed on optoacoustic equipment, and the left cantilever is fixed on mounting plate left end, and right cantilever is fixed on the mounting plate right side End, left sleeve are fixed on the bottom end of left cantilever, and the right sleeve is fixed on the bottom end of right cantilever;
The breathing mask is assemblied in inside left sleeve or right sleeve inner, his the mode bracket are fixed on left sleeve and right set The bottom of cylinder.
5. the method according to claim 4 realizing optoacoustic and his mode and being serially imaged, which is characterized in that the respiratory surface Cover includes mask body and mask bayonet, and the mask body includes the cylindricality pneumostome and taper sheath mouth being smoothly connected, described Mask bayonet is fastened in taper sheath mouth outer surface;The cylindricality pneumostome is connect with external oxygen input port, the taper sheath mouth For fixing measurand head.
6. the method according to claim 5 realizing optoacoustic and his mode and being serially imaged, which is characterized in that the taper sheath The inner surface of mouth, which is provided with, rises as high as the banks, the chin risen as high as the banks for placing measurand;The edge of the taper sheath mouth is provided with Waterproof grommet;The junction of the cylindricality pneumostome and taper sheath mouth is provided with copper wire, and the copper wire is for placing tested pair The tooth of elephant.
7. the method according to claim 6 realizing optoacoustic and his mode and being serially imaged, which is characterized in that the anti-watertight Seal is silica gel waterproof grommet.
8. the method according to claim 7 realizing optoacoustic and his mode and being serially imaged, which is characterized in that the left sleeve Including left outside sleeve and left inside sleeve, the right sleeve includes right outer sleeve and right inner sleeve, and the left inside sleeve slidably fills Assigned in left outside sleeve inner, the right inner sleeve is slidably assemblied in inside right outer sleeve.
9. the method according to claim 8 realizing optoacoustic and his mode and being serially imaged, which is characterized in that the left outside set Cylinder and right outer sleeve are provided with screw hole, and the screw hole is used to fix the four limbs of measurand;His mode bracket Middle position setting is fluted, and the groove is for keeping measurand abdomen hanging.
10. a kind of registration apparatus realizing optoacoustic and his mode and being serially imaged, which is characterized in that be set as such as claim 4 to 9 The registration apparatus.
CN201810583179.6A 2018-06-05 2018-06-05 Method for realizing serial imaging of optoacoustic and other modes and registration device Active CN109009182B (en)

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