CN109007161A

CN109007161A - A kind of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea and preparation method thereof

Info

Publication number: CN109007161A
Application number: CN201710435567.5A
Authority: CN
Inventors: 刘子元
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-06-11
Filing date: 2017-06-11
Publication date: 2018-12-18

Abstract

The present invention provides a kind of gynostemma pentaphylla hypoglycemic blood pressure depressing health teas, the parts by weight of various raw materials in the gynostemma pentaphylla hypoglycemic blood pressure depressing health tea are as follows: 10~50 parts of gynostemma pentaphylla, 10~20 parts of Cortex Magnoliae Officinalis, 10~20 parts of elscholtiza, 10~20 parts of herba lysimachiae, 10~20 parts of rhizoma imperatae, 10~20 parts of Poria cocos, 10~20 parts of Radix Salviae Miltiorrhizae, 10~20 parts of umbellate pore furgus, 10~20 parts of eupatorium, 10~20 parts of adlay, 10~20 parts of herba taxilli, 10~20 parts of semen plantaginis, 10~20 parts of radices trichosanthis, 10~20 parts of radix scutellariae, 10~20 parts of Rhizoma Atractylodis Macrocephalae, 10~20 parts of corn stigma.Gynostemma pentaphylla has reducing blood lipid, blood pressure lowering, hypoglycemic, calm, hypnosis, anti-anxiety, antiulcer, antifatigue, extension cell survival and improves a poor appetite, resistance building, unobstructed stool, antiasthmatic-antitussive, the hemorrhoid that disappear, the treatment chronic diseases marked by deficiency of vital energy, inhibit gall stone formation, prevention and treatment glucocorticoid side effect, anti-aging and other effects at weight-reducing.The present invention is using gynostemma pentaphylla blade as raw material, pure picked by hand, is process in conjunction with prepared slices of Chinese crude drugs technique by ancient method tea-manufacturing technology.Soup look of the present invention is dark green, and faint scent overflows, slight bitter glycol, is suitble to be used for a long time.

Description

A kind of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea and preparation method thereof

Technical field

The present invention relates to contain the health care product from plant composition, in particular to a kind of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea And preparation method thereof.

Background technique

The World Health Organization once clearly proposed that preventing the first line of defence of cardiovascular disease was exactly to reduce " three high " and control " three high ".Many diabetes patients are with hyperlipidemia, therefore diabetes and hyperlipidemia are usually called sister's disease by people, and Think that hyperlipidemia is the secondary disease of diabetes." three high diseases " refer to hypertension, hyperglycemia (diabetes) and hyperlipemia.Usual companion With obesity.They are that modern society is derived from " rich people's disease ", possible individualism, it is also possible to interrelated.Such as: sugar Urine patient be easy to suffer from hypertension or hyperlipemia simultaneously, and hyperlipidemia be artery sclerosis formation and development it is main because Element, arteriosclerotic's blood vessel elasticity difference is aggravated blood pressure and is increased, so the later period all forms " three high diseases ".

In the ten big causes of death of Chinese, the death rate relevant to metabolic disease is as high as 35.7%, with " three high " Relevant death toll also accounts for the 27% of total death toll.Hyperlipidemia can cause blood vessel embolism；Hypertension can cause brain to go out Blood and rupture of blood vessel in brain；Hyperglycemia can cause diabetes.About 40% diabetic has disorders of lipid metabolism according to statistics.Its Feature is that triglycerides increases and high-density lipoprotein reduction.

The present invention is using " gynostemma pentaphylla " blade as raw material, and wherein bud-leaf effect is best, pure picked by hand, by ancient legal system tea work Skill is process in conjunction with prepared slices of Chinese crude drugs technique.Soup look is dark green, and faint scent overflows, slight bitter glycol.Civil, gynostemma pentaphylla is used to control Hyperlipidemia is treated, hypertension, hyperglycemia is especially effective in cure to hyperlipidemia significant, is that its other medicine food is difficult to substitute.

By pharmacology, toxicity and clinical proof, gynostemma pentaphylla have extensive adaptability, have significantly to a variety of cancer cells Inhibiting effect；In addition, gynostemma pentaphylla there are also reducing blood lipid, blood pressure lowering, hypoglycemic, calm, hypnosis, anti-anxiety, antiulcer, it is antifatigue, Extend cell survival and improve a poor appetite, builds up resistance, unobstructed stool, antiasthmatic-antitussive, the hemorrhoid that disappear, weight-reducing, the treatment chronic diseases marked by deficiency of vital energy, inhibition Gall stone forms, prevents and treats the multiple efficacies such as glucocorticoid side effect, anti-aging.In addition to having effects that ginseng, also there is people Join a variety of effects not having, and reaction and any other toxic side effect without ginseng excessive use.

The health-care effect of gynostemma pentaphylla is mainly: 1, reducing blood lipid: gynostemma pentaphylla has significant decrease cholesterol (TCH), glycerol three Rouge (TG), low-density lipoprotein (LDL), increasing high density lipoprotein (HDL), protection blood vessel cell, prevent lipid in blood Tube wall deposition, the effect of anti arteriosclerosis.Adjust blood pressure to prevent and treat thrombus: gynostemma pentaphylla has apparent reduction blood viscosity, adjustment blood Pressure function can prevent microvascular corrosion cast simultaneously and increase cardiac muscle cell to the tolerance of anoxic, play the effect of protection cardiac muscle.Blood Bolt is caused by a variety of factors, and internal and external test all proves, the thrombus that Herb Gynostemmae Pentaphylli extract forms a variety of factors has good Depolymerization inhibits function, shows that gynostemma pentaphylla is that have to inhibit multiple rings such as platelet function, coagulation function and erythrocyte aggregation Save the anti-thrombosis drug of function.2, prevent and treat cardiovascular disease: Herb Gynostemmae Pentaphylli extract has Myocardial Infarction obvious Protective effect: can reduce myocardial infarct size, inhibit free fatty acid (FFA) after myocardial infarction to increase, reduce malonaldehyde (MDA) content protects SOD of heart tissue and creatine phosphokinase (CPK) activity, the metabolic disorder of FFA when correcting myocardial ischemia.Cause This, has good protective effect to myocardial ischemia and Ischemia Reperfusion damage.The regulating lipid metabolism and antioxygen of gynostemma pentaphylla are turned into With the prevention and treatment for being beneficial to atherosclerosis, clinical test also demonstrates the good result of Jiaogulan in treating coronary heart disease.3, it adjusts Save blood glucose: gynostemma pentaphylla can protect adrenal gland and thymus gland and endocrine organ, maintain the normal function of endocrine system.Exactly by In this effect of gynostemma pentaphylla, so it has hypoglycemic and improvement carbohydrate metabolism.4, human physiological functions: gynostemma pentaphylla are adjusted Adrenal gland and thymus gland and endocrine organ can be protected with the growth at age and will not atrophy, maintain the function of endocrine system, and With hypoglycemic and improvement carbohydrate metabolism.

Modern selects some health foods or functional food to be provided to keep fit and healthy.The function of health care product mainly changes Kind brain blood circulation adheres to physical training and suitably using psychotropic agent.The present various health care products sold on the market, drug fish Dragon mixes, and the amusement of most of only false propagandas, some not only without health-care components, also causes the huge injury of human body, Therefore, search of health effectively softens blood vessel method with very real significance, safely and effectively softens vasoactive object Matter is always that people expect the key solved the problems, such as.Chinese medicine hypoglycemic decompression, have it is nontoxic, can be fully absorbed by organism it is excellent Point is the Main way that we study.There is an urgent need to develop one kind to have reducing blood lipid, antibacterial, hypoglycemic, antioxygen to be turned into present market With, and body can be interfered to the absorption of fat, promote the product that excretes of fat of intake, and have it is nontoxic, can be biological The advantages of body fully absorbs.

Summary of the invention

Technical problem to be solved by the present invention lies in the decompression of, Chinese medicine hypoglycemic, have it is nontoxic, can be fully absorbed by organism The advantages of, it is the Main way that we study.There is an urgent need to develop one kind reducing blood lipid, antibacterial, hypoglycemic, antioxygen in present market Change effect, and body can be interfered to the absorption of fat, the product for promoting the fat of intake to excrete, and there is nontoxic, energy quilt The advantages of organism fully absorbs.Gynostemma pentaphylla has reducing blood lipid, blood pressure lowering, hypoglycemic, calm, hypnosis, anti-anxiety, antiulcer, resists Fatigue extends cell survival and improves a poor appetite, and builds up resistance, unobstructed stool, antiasthmatic-antitussive, and the hemorrhoid that disappear, weight-reducing, treatment are empty Disease inhibits gall stone to be formed, prevents and treats the multiple efficacies such as glucocorticoid side effect, anti-aging；The present invention promotes body fat generation It thanks and is allowed to balance, to reach reducing blood lipid, reverse the feeding effects such as fatty liver, while to weight-reducing, defaecation, toxin expelling, promoting sleep effect Fruit is definite.The present invention is using gynostemma pentaphylla blade as raw material, pure picked by hand, by ancient method tea-manufacturing technology in conjunction with prepared slices of Chinese crude drugs technique It is process.Soup look of the present invention is dark green, and faint scent overflows, slight bitter glycol；Along with some activating microcirculation and removing stasis medicinal, to fat and serum glycerol Three esters have the Chinese medicine for the effect of being substantially reduced, and can improve microcirculation, make one to be easy to receive, reach the function of daily health caring, The effect of more capable of preferably reaching hypoglycemic decompression.

To solve above-mentioned technical problem, the present invention provides a kind of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea, the gynostemma pentaphylla hypoglycemic The parts by weight of various raw materials in blood pressure depressing health tea are as follows: 10~50 parts of gynostemma pentaphylla, 10~20 parts of Cortex Magnoliae Officinalis, 10~20 parts of elscholtiza, gold 10~20 parts of money grass, 10~20 parts of rhizoma imperatae, 10~20 parts of Poria cocos, 10~20 parts of Radix Salviae Miltiorrhizae, 10~20 parts of umbellate pore furgus, eupatorium 10~20 Part, it is 10~20 parts of adlay, 10~20 parts of herba taxilli, 10~20 parts of semen plantaginis, 10~20 parts of radices trichosanthis, 10~20 parts of radix scutellariae, white 10~20 parts of art, 10~20 parts of corn stigma.

The gynostemma pentaphylla hypoglycemic blood pressure depressing health tea, the parts by weight of various raw materials in the gynostemma pentaphylla hypoglycemic blood pressure depressing health tea Number can be with are as follows: and 10~30 parts of gynostemma pentaphylla, 10~15 parts of Cortex Magnoliae Officinalis, 10~15 parts of elscholtiza, 10~15 parts of herba lysimachiae, rhizoma imperatae 10~15 Part, 10~15 parts of Poria cocos, 10~15 parts of Radix Salviae Miltiorrhizae, 10~15 parts of umbellate pore furgus, 10~15 parts of eupatorium, 10~20 parts of adlay, herba taxilli 10 ~20 parts, 10~20 parts of semen plantaginis, 10~20 parts of radices trichosanthis, 10~20 parts of radix scutellariae, 10~20 parts of Rhizoma Atractylodis Macrocephalae, corn stigma 10~20 Part.

The gynostemma pentaphylla hypoglycemic blood pressure depressing health tea, the parts by weight of various raw materials in the gynostemma pentaphylla hypoglycemic blood pressure depressing health tea Number can be with are as follows: and 10~40 parts of gynostemma pentaphylla, 10~20 parts of Cortex Magnoliae Officinalis, 10~20 parts of elscholtiza, 10~20 parts of herba lysimachiae, rhizoma imperatae 10~ 20 parts, 10~20 parts of Poria cocos, 10~20 parts of Radix Salviae Miltiorrhizae, 10~20 parts of umbellate pore furgus, 10~20 parts of eupatorium, 10~15 parts of adlay, herba taxilli 10~15 parts, 10~15 parts of semen plantaginis, 10~15 parts of radices trichosanthis, 10~15 parts of radix scutellariae, 10~15 parts of Rhizoma Atractylodis Macrocephalae, corn stigma 10~15 Part.

In order to solve the above technical problems, the present invention also provides a kind of preparation method of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea, institute The preparation step for stating gynostemma pentaphylla hypoglycemic blood pressure depressing health tea includes following aspect:

A. the preparation of gynostemma pentaphylla；

B. the gynostemma pentaphylla Titian fried；

It c. will other described raw material soaking ethyl alcohol heating extractions；

D. the medical fluid that surplus stock extracts is condensed into granule, pulvis or paste again；

E. the granule of concentration, pulvis or paste are mixed with the gynostemma pentaphylla prepared, sterilizing is prepared into health care medicinal tea；

In the step a, the fresh and tender gynostemma pentaphylla of picked by hand, sunning is parched；The gynostemma pentaphylla dried is put into water-removing pot In go blueness, finish 30-45 minutes at 70-100 DEG C, be then placed in big iron pan and stir-fry, first downwards after upwards, firmly want Uniformly, when gynostemma pentaphylla color starts to turn to be yellow, beginning small fire stir-fries 20-30 minutes and forms.

In the step b, the gynostemma pentaphylla fried can be put into fragrance extracting machine Titian 30-45 minutes, be dried in the air naturally after taking-up It is dry.

In the step c, other raw materials can be taken to be added in the 5-10 times of ethyl alcohol measured and impregnated 1-2 hours, heating extraction 2 Secondary, 1-2 hours each, removing supernatant, combined extract, the filtration of 100-120 mesh, then the molecular weight that shut off is 5000-10000's When relative density is 80 DEG C 1.36 medicinal extract is concentrated under reduced pressure in ultrafiltration column ultrafiltration, ultrafiltrate, and heating is concentrated into paste, stand for standby use.

In the step d, the medicinal extract of concentration can be placed in economic benefits and social benefits vacuum concentrator, relative density when being concentrated into 90 DEG C For 1.05 concentrate, 0~5 DEG C of deepfreeze is set 24 hours；Refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate It is placed in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount containing 1g；Paste after concentration adds honey reconciliation that particle is made Agent；Or pulvis is made in convection drying.

In the step e, the gynostemma pentaphylla made can be mixed with other raw materials refined, after ultraviolet ray sterilization bactericidal Pack.

In order to solve the above technical problems, the present invention provides a kind of preparation method of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea again, Preparation step can be with are as follows: can be put into surplus stock component in 10 times of amount ethyl alcohol, heating and refluxing extraction 2 times, every time 1~2 Hour, No. 2 extracting solutions are merged and are stood；The dregs of a decoction for the component raw medicinal material that above-mentioned ethyl alcohol extracted are added into 10 times of amount water heating again Refluxing extraction 2 times, 1~2 hour every time, No. 2 extracting solutions is merged and are stood；Above two extracting solution is merged, phase is concentrated under reduced pressure To density be 80 DEG C when 1.35 filtrate, recycle ethyl alcohol, by gained filtrate adjustment specific gravity to 1.06, depressurize to obtain medicinal extract, then plus Honey reconciles, and is put into granulator and 1-2 centimetres of granule is made, be condensed into paste or pulvis is made in convection drying.

The present invention is beneficial to be had technical effect that, for the present invention using gynostemma pentaphylla blade as raw material, wherein bud-leaf effect is best, pure Picked by hand is process in conjunction with prepared slices of Chinese crude drugs technique by ancient method tea-manufacturing technology.Soup look of the present invention is dark green, and faint scent overflows, Slight bitter glycol.Gynostemma pentaphylla has reducing blood lipid, blood pressure lowering, hypoglycemic, calm, hypnosis, anti-anxiety, antiulcer, antifatigue, extension cell It service life and improves a poor appetite, builds up resistance, unobstructed stool, antiasthmatic-antitussive, the hemorrhoid that disappear weight-reducing, the treatment chronic diseases marked by deficiency of vital energy, inhibit gall stone shape At, prevention and treatment glucocorticoid side effect, the multiple efficacies such as anti-aging；The present invention promotes body fat to be metabolized and is allowed to balance, from And reach reducing blood lipid, the feeding effects such as fatty liver are reversed, while to weight-reducing, defaecation, toxin expelling, it is definite to promote sleeper effect.Research shows that: Gynostemma pentaphylla is in addition to containing other than gynosaponin, also containing Flavonoid substances, polysaccharide, phosphatide, amino acid, vitamin, constant and micro- Measure inorganic elements isoreactivity composition.Along with some activating microcirculation and removing stasis medicinal, effect is substantially reduced to fat and serum triglyceride Chinese medicine, and microcirculation can be improved, make one to be easy to receive, reach the function of daily health caring, more can preferably reach hypoglycemic drop Pressure, for three high crowds daily health caring the effect of.

Specific embodiment

Reinforce the research that influences on patients ' life quality of traditional Chinese medicine hypoglycemic: as medicine is from pure biological pattern to " social one One psychology of biology " mode conversion, it is not enough with biomedical indicators evaluation curative effect merely to diabetes, it should focus on to minimal invasive treatment The improvement of quality.Diabetes somatization is the important content of quality of life, is caused since insulin is absolute or relative deficiency Caused by sugar, protein, fatty disorder.Traditional Chinese medicine is conceived to whole medical treatment and hypoglycemic, while can correct these functional disturbances and energy Improve somatization, improves the quality of living.As it can be seen that traditional Chinese medicine has potential advantages in this respect.

Due to economic increasingly flourishing, the continuous promotion of modern standard of living, cause people it is excessive have deep love for enjoying, no Pay attention to oneself life style, behavioural habits, diet hobby, so as to cause disease.Society with fast rhythm's life, keen competition Operating pressure, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, table It is existing are as follows: dizzy, nervous, out of strength, loss of appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet does not conform to Reason, it may be assumed that smart grain replaces coarse food grain completely, a large amount of three high (high fever, high protein, high-fat), more than three (preservative is more, flavoring agent is more, Hormone is more) remaining pesticide, chemical fertilizer stockpiling in vivo in the intake of food and food, add air, pollution of waterhead and fortune Momentum is less than normal, goes down to make three high diseases (hypertension, hyperglycemia, hyperlipidemia), cardiovascular and cerebrovascular disease, cancer etc. so-called for a long time in this way " modern civilization diseases " rapidly rise, and continuous rejuvenation, the serious health and lives for jeopardizing the mankind.

When the reason of diabetes cause blood lipid to increase is due to diabetes patient's insufficient insulin, internal lipase activity is to subtract Low, therefore be easy blood lipid and increase.Another aspect diabetes itself in addition to carbohydrate metabolism disturbance simultaneously also with fat, protein and Water, dielectric disorder.Often there is free fatty acid to mobilize from fat depot to come out, makes triglycerides and free fatty acid in blood Concentration increases.Another further aspect diabetes B people feed is excessive, and movement is few, promotes internal lipid synthesis to increase, this is also to cause blood The reason of rouge increases.And it is fat with hyperlipidemia person, it is reduced since insulin receptor number is opposite, to generate insulin resistance, easily Induced Diabetic.Diabetes are that carbon aquation caused by defect is existed simultaneously due to insulin secretion, insulin action or both Close a kind of syndrome of object, protein and fat metabolic disturbance.Essential characteristic is that blood glucose increases, and long-term damage is various organs Dysfunction and failure, including the vascular conditions being constantly in progress, i.e. retinopathy, blindness, nephrosis, renal failure, mind Change through lesion with foot ulcers, amputation and autonomic nervous function, there are also the ever-increasing cardiovascular, cerebrovascular and peripheral vessels The danger of lesion.

Clinical application proves that gynostemma pentaphylla has the function of " adapting to source " sample, there is significant inhibiting effect to a variety of cancer cells；This Outside, there are also reducing blood lipid, blood pressure lowering, hypoglycemic, calm, hypnosis, anti-anxiety, antiulcer, antifatigue, extension cell survivals for gynostemma pentaphylla And improve a poor appetite, build up resistance, unobstructed stool, antiasthmatic-antitussive, the hemorrhoid that disappear, weight-reducing, treatment the chronic diseases marked by deficiency of vital energy, inhibit gall stone formed, Prevent and treat the multiple efficacies such as glucocorticoid side effect, anti-aging.In addition to having effects that ginseng, also there is ginseng not have more Kind effect, and reaction and any other toxic side effect without ginseng excessive use.Reducing blood lipid: gynostemma pentaphylla has significant drop Low cholesterol (TCH), triglyceride (TG), low-density lipoprotein (LDL), increasing high density lipoprotein (HDL), protection are intravascular Parietal cell prevents lipid from depositing in vascular wall, the effect of anti arteriosclerosis.Adjust blood pressure to prevent and treat thrombus: gynostemma pentaphylla has apparent Blood viscosity, adjustment blood pressure function are reduced, microvascular corrosion cast can be prevented simultaneously and increases cardiac muscle cell to the tolerance of anoxic, is risen To the effect of protection cardiac muscle.Thrombus is caused by a variety of factors, and internal and external test all proves, Herb Gynostemmae Pentaphylli extract is to a variety of factor shapes At thrombus have good depolymerization or inhibit function, show that gynostemma pentaphylla is that have to inhibit platelet function, coagulation function and red The anti-thrombosis drug of multiple link functions such as cell aggregation.Prevent and treat cardiovascular disease: Herb Gynostemmae Pentaphylli extract is to experimental Myocardial infarction has significant protective effect: can reduce myocardial infarct size, inhibit free fatty acid (FFA) after myocardial infarction It increases, reduces malonaldehyde (MDA) content, protect SOD of heart tissue and creatine phosphokinase (CPK) activity, FFA when correcting myocardial ischemia Metabolic disorder.Therefore, there is good protective effect to myocardial ischemia and Ischemia Reperfusion damage.The adjusting lipid generation of gynostemma pentaphylla It thanks and antioxidation is beneficial to the prevention and treatment of atherosclerosis, clinical test also demonstrates the good of Jiaogulan in treating coronary heart disease Good effect.Adjust blood glucose: gynostemma pentaphylla can protect adrenal gland and thymus gland and endocrine organ, maintain the normal machine of endocrine system Energy.Just because of this effect of gynostemma pentaphylla, so it has hypoglycemic and improvement carbohydrate metabolism.Adjust Human Physiology machine Can: gynostemma pentaphylla adrenal gland and thymus gland and endocrine organ can be protected with the growth at age and will not atrophy, maintain endocrine system Function, and have it is hypoglycemic and improve carbohydrate metabolism.

The present invention is using " gynostemma pentaphylla " blade as raw material, and wherein bud-leaf effect is best, pure picked by hand, by ancient legal system tea work Skill is process in conjunction with prepared slices of Chinese crude drugs technique.Soup look is dark green, and faint scent overflows, slight bitter glycol.It is suitble to hyperlipidemia, diabetes patient long Phase takes.

Adlay is that common Chinese medicine is food that is universal, often eating again, and property slightly sweet flavor is slightly cold, has inducing diuresis for removing edema, invigorating the spleen to go Wet, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus and other effects are common damp-clearing drug.Adlay is a kind of beauty food again, and often feeding can be protected It is fine and smooth to hold human skin gloss, eliminates acne, spot sparrow, senile plaque, cyasma, butterfly macules, it is thick to furfur, acne, chap, skin Rough wait has good efficacy.The kind Renhe root of Semen Coicis can be used as medicine again cures the disease.Li Shizhen (1518-1593 A.D.) is recorded in Compendium of Material Medica: Semen Coicis energy " Invigorating spleen and reinforcing stomach, tonifying lung heat-clearing, removes wind prevailing over dampness.It cooks a meal food, controls cold air.Decoct drink, diuresis heat gonorrhea." in recent years, a large amount of science is ground Studying carefully proves with clinical practice, and Semen Coicis or a kind of anticancer drug, Preliminary Identification, it is to the inhibiting rate of cancer up to 35% or more.

Eupatorium expelling summer-heat and damp is warded off dirty in.It cures mainly and experiences summer-heat and damp；Fever and chills headache；Accumulate in wet；Gastral cavity ruffian is not hungry；Nausea is vomitted It spits；It is sweet in mouthful；Disappear truly " Bencao Jingshu ": lung governing qi, lung qi pent-up, then upper orifices is closed and lower orifices are obstructed, and stomach master receives trough, stomach The obstruction of the circulation of vital energy is stagnant, then trough not with when and be phlegm addiction, fragrant thoroughwort it is pungent it is flat can dissipating bind it is stagnant, fragrance can remove dirty evil, then come up it is all demonstrate,prove from recover, greatly All appetizing is except evil, clearing lung-heat dissolving phlegm, the panacea of Disperse hepatic depression." key medicine divides agent ": fragrant thoroughwort removes the product for disliking, dissipating Yu Xiejie for dissolving phlegm, "Nei Jing" is quenched one's thirst treating with Herba EuPatorii, removing the accumulation of stale pathogen.Lid is quenched one's thirst by heat symptoms caused by an exopathgen pent-up in stomach, blue energy removing the accumulation of stale pathogen.Know that fragrant thoroughwort is solid to cleanse For function, stomach person is eliminated.

Rhizoma imperatae is clearing heat and detoxicating the major functions: cooling blood and hemostasis.For spitting blood, hematuria, heat gonorrhea, oedema, jaundice, difficult urination, heat Sick polydipsia, stomach hot vomiting, cough.Shennong's Herbal: " main internal lesion caused by overexertion void is thin, tonifying middle-Jiao and Qi, except hemostasis, blood close fever and chills, diuresis." " not Record ": " lower five leaching are quenched the thirst except visitor's heat is in stomach, hard muscle, married woman's metrorrhagia.", " materia medica ": rhizoma imperatae, it is cold and cool and taste is very sweet, The heat that can be purified the blood point, it is sticky without hurting drying, and not, therefore cool blood accumulates the stasis of blood without considering its, with main hematemesis spitting blood.Drop-down fire is inverse, Effect is very prompt, therefore main stomach fire hiccup vomiting, the asthma of the lung heat circulation of vital energy in the wrong direction are full again.And sweet cold and greasiness liquid, though drop it is inverse and different from bitter dry, then again only It promotes the production of body fluid yearningly, and washs the latent heat between lung stomach and intestine clearly, it is dry thirsty that the paddy that disappears can be treated.Again can treating stranguria close and control blood under haematuria, and housewife female's blood-head Absurd row, metrorrhagia drench band.The small water of tonneau, the oedema for the knot that expels the heat-evil again lead the jaundice of stagnant heat, all sweet cold actual effect removed heat by catharsis.So its is sweet cold Power, let out lung stomach clearly, there is speciality especially, all dentalgia gums are swollen, and all sores of noma dispute and the strongly fragrant pharyngalgia stopped up of lung heat are rotted all cards, to Assistant makes, and effect most writes, and without abuses.

Cortex Magnoliae Officinalis is bitter；It is pungent；It is warm-natured.The spleen channel；Stomach meridian；Large intestine channel.Gas consumption product；Eliminating dampness except full；Relieving asthma.The major functions: dyspepsia The stagnation of the circulation of vital energy；Abdominal distention constipation；Damp retention in middle-jiao, abdominal swelling and diarrhea；Phlegm stops up the circulation of vital energy in the wrong direction；Chest full of cough.Cortex Magnoliae Officinalis decoction has suppression to toad isolated heart Production magnocurarine drug administration by injection, has obvious antihypertensive effect when being lower than muscle relaxant amount, which cannot be by antihistamine institute Antagonism, the decompression of Bolos intravenous administration are held time about 10~15 minutes, the decompression of intramuscular administration hold time then up to 1 hour with The tincture hydrotrope of upper Flos Magnoliae Officinalis has antihypertensive effect to anesthetized cat, rabbit intravenous or intramuscular injection, and can make increased heart rate.Other are made With: Cortex Magnoliae Officinalis decoction has excitation honokiol, magnolol to by ADP, DAF and fibrin guinea pig bronchial smooth muscle Enzyme etc. causes the platelet aggregation of poly- agent induction and ATP release to have the methanolic extract honokiol pair for significantly inhibiting effect Cortex Magnoliae Officinalis Mouse skin tumour caused by second phase carcinogenic test has apparent inhibiting effect in vivo." Bencao Jingshu ": Cortex Magnoliae Officinalis, main apoplexy, wound Cold headache, fever and chills, the dead flesh person of qi and blood numbness, for lid with chill exopathogen, wound is then fever and chills headache in sun point；Chill it is wet enter space between skin and muscles, then gas Blood clotting is puckery to form numbness, very then numbness, this medicine it is pungent can dissipating bind, it is bitter can bath it is wet, warm can cold-dispelling, therefore know main." not Record " and main middle benefit gas, dissolving phlegm, lower gas, cholera and abdominal pain turgor are treated, cold in the stomach is inverse, vomits in the heart more than, lets out the vexed full person of dysentery.

Radix Salviae Miltiorrhizae is bitter, slightly cold.Converge to heart and liver channels.Stasis-dispelling and pain-killing, blood circulation, relieving restlessness and restlessness.For irregular menstruation, menostasis pain Through a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore and ulcer, swelling and pain, upset and sleepless.For sternal rib hypochondriac pain, rheumatic arthralgia, abdominal mass knot Block, sore swell and ache curative fall servant's pain of injury, irregular menstruation, amenorrhea and algomenorrhea, postpartum stasis caused pain etc..Sternal rib pain, abdominal mass caking are treated, and Irregular menstruation, menostasis dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, presses " the sensible opinion of married woman " cloud, and Siwu Tang is controlled gynecopathy, paid no attention to Antenatal postpartum, through water how much, it is all generally applicable, only taste Radix Salviae Miltiorrhizae dissipate, cure mainly same.Lid Radix Salviae Miltiorrhizae can break place blood, mend new blood, peace Green tire falls stillborn foetus, under only metrorrhagia is stagnant, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has expansion blood vessel, improves circulation, releases blood vessel The effects of intravascular coagulation, has the effect of promoting blood circulationization trace, and liver blood can be promoted to recycle, and is conducive to liver cell regeneration.

Poria cocos is sweet in flavor, light, mild-natured, is used as medicine with clearing damp and promoting diuresis, beneficial spleen and stomach, the function of antitoxic heart-soothing and sedative.Modern medicine is ground Study carefully: Poria cocos can enhance body's immunity, and pachymaran has apparent antitumor and liver protecting effect.Poria cocos slightly sweet flavor is flat, Enter the heart, lung, the spleen channel.With eliminating dampness and diuresis, the effect of strengthening the spleen and stomach, antitoxic heart-soothing and sedative.Difficult urination, edema swelling, phlegm retention can be controlled Cough is inverse, vomits inverse, vomiting during early pregnancy, diarrhea, spermatorrhea, stranguria with turbid discharge, palpitation with fear, the diseases such as amnesia.The Li Shui of Poria cocos is reached by strong fortune spleen and lung function It arrives, it is different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, leukorrhagia Poria cocos can invigorating the spleen and excreting dampness, for spleen deficiency Diarrhea caused by dysfunction of the spleen in transportation and transformation, leukorrhagia have the benefits of giving consideration to both the incidental and fundamental using Poria cocos, often with the compatibilities such as umbellate pore furgus, Rhizoma Atractylodis Macrocephalae, Chinese yam.Have available For tonifying lung spleen, the adjuvant of the deficiency of vital energy is controlled.

Herba taxilli: sweet；It is mild-natured.Nourishing liver and kidney；Strengthening the bones and muscles；Wind-damp dispelling；Miscarriage prevention.Main soreness of waist and knee joint；Muscles and bones impotence is weak；Limbs are inclined It is withered；Rheumatic arthralgia；Head is wrong dizzy；Threatened abortion, metrostaxis.For rheumatic arthralgia, soreness and weakness of waist and knees, muscles and bones is powerless, metrorrhagia and metrostaxis warp It is more, blood leaking in gestation, threatened abortion；Hypertension." this is through meeting original ": the residual air of parasitic mulberry and give birth to, the special wind-dispelling of property leads to and adjusts blood by wet Arteries and veins, therefore Shennong's Herbal takes and controls married woman's pain in the loins, the diseases such as children's back is strong, Xuemaitong tune and skin eyebrow must have carbuncle swells all by its shade, also It dissipates." book on Chinese herbal medicine is looked for the truth ": herba taxilli number wants agent for kidney tonifying and enriching blood.Edge Shen controls bone, sends out blood main, bitter man's kidney, and kidney must mend then muscles and bones It effectively, will not hemorrhoid and sour repeatly.Sweet to enrich blood, blood must be mended, and hair is filled shade by it and fallen off without tangerine.Therefore it is all in and pain in the loins, muscles and bones Sincere disease, tire are fallen, outer and metal-inflicted wound, skin rheumatism, what is not one whereby with to cure mainly.

Radices trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, is clearing heat-fire class drug, specific effect is clear Hot purging intense heat, promotes the production of body fluid to quench thirst, apocenosis detumescence.The major functions: controlling, pyreticosis is thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle swells, hemorrhoid impotence.For controlling Diabetes are treated, it is commonly used and is used cooperatively with drugs for nourishing yin, to have the function that treating both manifestation and root cause of disease." collected statements on the herbal foundation ": radices trichosanthis moves back the five internal organs Hot and suffocating, if internal heat is contained and dry tongue and mouth, lung-fire is contained and pharynx swelling sore throat, and spleen fire is contained and dispute tooth is swollen, and convulsive seizure due to phlegm-fire is contained and coughed not peaceful.If Walking that the side of body of irascibility is swollen, the hectic fever due to yin dysphoria with smothery sensation or ulcer of kidney fire, which have been burst, does not burst, and heat toxin does not dissipate or five subcutaneous ulcer yellow skin and eyes, and small water If being caused by all burning hot pent-up, only this agent energy relieving stagnation, drops convulsive seizure due to phlegm-fire, and can control it if leaching is puckery.Its property is sweet cold again, kind to control yearningly, It is controlled from tonic empty thirsty, is controlled from the medicine of a cold nature fiery thirsty, controlled from gas medicine strongly fragrant thirsty, control polydipsia from blood medicine, be controlling thirsty key medicine.

Radix scutellariae: radix scutellariae has heat-clearing and damp-drying drug, cool blood miscarriage prevention, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, lung heat cough It coughs, the diseases such as neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, carbuncle swells furuncle sore.The clinical application of radix scutellariae is anti- Bacterium is not worse than the coptis, and does not develop drug resistance.Our features strong by broad-spectrum antibacterial action is used in the sense of fungal culture miscellaneous bacteria Dye is special severe, fine with radix scutellariae extracting solution effect." Bencao Jingshu ": radix scutellariae, property is respectful clearly, so evil removing: bitter is so eliminating dampness； Cold sensation of the genitalia is so victory is hot, therefore leads all heat.All hot persons, for heat symptoms caused by an exopathgen with all over heat, jaundice, intestines are out-of-the-way, let out dysentery, and the disease of all damp and hot victory analyses it This, then it is all sick from recover.Bitter cold can be except damp and hot, so small intestine benefit and water are from by source is then flowed clearly clean.The blood person of closing, real heat is in blood Point, i.e. thermal man's blood room, it is obstructed to make us menostasis, damp and hot solution, then Ying Qi it is clear and voluntarily.Malignant sore subcutaneous ulcer erosion person, blood-head then stays knot, and is Carbuncle swells stain is rotten: fiery ulcer person, internal heat blood trouble, and cool blood is except heat, then self-healing.Radix scutellariae has antiallergic action and anti-inflammatory effect: yellow Baicalin contained by a kind of reed mentioned in ancient books and baicalein can obviously inhibit sensitized guinea pig rat small intestine in vitro and isolated tracheal to anaphylaxis caused by antigen Contractile response, to the passive systemic allergy and cavy passivity skin allergic reaction of cavy and mouse, baicalin with Baicalein also has inhibiting effect.Radix scutellariae has refrigeration function, and majority test proves that the effective ingredient baicalein of radix scutellariae has antipyretic work With.Radix scutellariae has detoxication, and baicalin has apparent detoxication, this may be due to the effect in glucuronidase Under, baicalin decomposites glucuronic acid, and in conjunction with a variety of poisonous substances caused by.10 milligrams of the baicalin LD50 that can improve strychnine Up to 2.5 times, and increase the hepatic glycogen content of carbon tetrachloride poisoning mouse.

Rhizoma Atractylodis Macrocephalae bitter, sweet, warm.Returns spleen, stomach meridian.Cure mainly strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention.It is eaten for spleen deficiency It is few, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, threatened abortion.Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce oncocyte Proliferation rate, lower the invasion of tumor tissue, improve the ability of the antitumor reaction of body.Baizhu volatile oil is to mouse Emhorn ascites (Eca109, sarcoma 180 etc. have inhibiting effect for cancer, lymphosarcoma ascitic type, the cancer of the esophagus.Atractylodes lactone B is injected intraperitoneally to small rat meat The tumor people.Also effect is significantly inhibited." haigoushen " carries it: monarch, sweet in flavor, pungent, nontoxic.The main big wandering arthritis of energy, many years diarrhea due to disorder of qi, abdominal distnetion Bitterly, eliminate dyspepsia is broken, sputum is removed in appetizing, removes fever and chills, only lets out down.Interarea light is happy, preserves youthful looks, de-black.Edema swelling is controlled, inverse, abdomen of vomitting is spat Interior crymodynia, vomiting and diarrhoea does not live and the cold dysentery of stomach Qi deficiency.

Corn stigma is also referred to as maize palpus.Medicinal record earliest sees " the southern regions of the Yunnan Province book on Chinese herbal medicine " in 1476, is the traditional Chinese medicine in China Material, " Chinese Pharmacopoeia " record for 1977.It is included for " Ministry of Health of the People's Republic of China's medicinal material standard " 1985 editions (one) normal With medicinal material kind.Motherland's medicine thinks, corn stigma slightly sweet flavor and put down, enter liver, kidney, bladder meridian, there is inducing diuresis to remove edema, calming the liver and benefiting the lungs Function, cure mainly acute and chronic ephritis, oedema, acute cholecystitis, Biliary Calculi and hypertension etc..Modern pharmacological studies have shown that beautiful Rice must contain a large amount of potassium nitrate, vitamin K, sitosterol, stigmasterol and a kind of volatile alkaloid.Have diuresis, decompression, it is hypoglycemic, The effects of hemostasis, cholagogue.Therefore it is a lot of with the proved recipe that the product are made of main ingredient, it cures the disease also very extensive.

Elscholtiza acrid-sweet flavor, it is warm-natured, it is nontoxic.Return lung, stomach, the spleen channel.Inducing sweat and dispelling exogenous evils, dampness elimination is in, inducing diuresis for removing edema；Sweating solution Heat, row water dissipate it is wet, in warm stomach tune.It is cold to control the cold drink of Xia Yue sense, has a headache and fever, aversion to cold is lossless, feeling of stuffiness in chest abdominal pain, vomiting and diarrhoea, oedema, Tinea pedis.Herba Moslae volatile oil all has stronger direct suppression to the Ileum From A White Spontaneous Contraction activity of mouse, rat, cavy and rabbit Production is used, but to the sensibility of the animal of different genera difference, in contrast, to the inhibiting effect of cavy and Rabbit Ileum compared with By force, effective dose 50 is respectively 3.6 and 7.6 μ g/ml, and slightly weak to the effect of rat and mouse, and effective dose 50 is 14.2 Hes 35.1μg/ml.To guinea pig ileum anaphylaxis because of caused by egg white shrink and barium chloride caused by anaphylaxis contraction have pair Anti- effect." book on Chinese herbal medicine " cloud: main abdominal pain due to acute vomiting and diarrhea is spat down, and aproll is swollen.

Herba lysimachiae, Chinese medicine name.For Ofthe Primulaceae Lysimachia christinae, scientific name: Lysimachia christinae Hance, Drying herb.Jiangnan each province is distributed.Summer, the harvesting of two season of autumn.Impurity is removed, is dried, dissection is raw to be used.With heat-clearing solution The effect of poison, eliminating stasis to subdue swelling, removing dampness through diuresis and removing jaundice, can be used for heat gonorrhea, and Sha Lin, urine is puckery to have a pain, jaundice and reddish urine, carbuncle swells furunculosis, and poisonous snake stings Wound, liver and bile stone, the diseases such as lithangiuria.Modern study, the product mainly contain phenolic constituent and sterol, flavonoids, amino acid, tan Matter, volatile oil, choline, sylvite etc..Also there is row's stone, antibacterial, anti-inflammatory effect has inhibition to make humoral immunity, cellular immunity With.

Semen plantaginis is distributed in lung channel；Liver Channel；Kidney channel；Bladder meridian.Function: reducing fever and causing diuresis；Excreting dampness antidiarrheal；Improving eyesight；Eliminating the phlegm.The major functions: Main difficult urination；Under the turbid belt；Edema swelling；Summer-heat and damp dysentery；Hot eyes is hidden from view；The asthma of phlegm heat-syndrome cough.1. diuresis, normal person is for oral administration Semen plantaginis decoction 10g, there is a diuresis, but decoction total capacity and enters water daily without record, lacks stringent control.Normal person And rabbit takes Chinese herbaceous peony grass seed decoction then without obvious diuresis." pharmacological property is fallen ": can go wind toxin, and hepatic stroke is warm, malicious wind dotting punch mesh, Red pain is hidden from view, and ambition dysphoria with smothery sensation is gone in cerebralgia lacrimation." Japan hanako materia medica ": diuresis drenches puckery, establishing-Yang.De- essence is controlled, it is vexed.Lower gas.

Umbellate pore furgus: enter the heart, spleen, stomach, lung, kidney, warp.Clearing damp and promoting diuresis.Control difficult urination, oedema, diarrhea, stranguria with turbid discharge, leukorrhagia.It is more Hole Cordycepps Polyporus plant umbellate pore furgus Polyporus umbellatus (Pers.) Fr. [Grifola umbellataPilat] Sclerotium.Nature and flavor are flat, sweet, light.There are diuresis, the function of excreting dampness.Discovered in recent years umbellate pore furgus has antitumaous effect.For acute kidney Inflammation, anasarca, oedema, difficult urination, heat gonorrhea, urgent urination, frequent micturition, urethralgia is thirsty, and drinking-water is then spat, watery diarrhea of suffering from heatstroke, jaundice etc. Illness.

Specific embodiment 1:

First by gynostemma pentaphylla frying, Titian.

Again by remaining raw material Cortex Magnoliae Officinalis, elscholtiza, herba lysimachiae, rhizoma imperatae, Poria cocos, Radix Salviae Miltiorrhizae, umbellate pore furgus, eupatorium, adlay, herba taxilli, Semen plantaginis, radices trichosanthis, radix scutellariae, Rhizoma Atractylodis Macrocephalae, corn stigma extract, paste, granule or pulvis are made.

Two kinds of extract mixing, ultraviolet radiation for sterilizing and disinfecting pack.

Specific embodiment 2:

The fresh and tender gynostemma pentaphylla 5000g of picked by hand, sunning, parches；The gynostemma pentaphylla dried is put into water-removing pot and goes blueness, It finishes 30-45 minutes at 70-100 DEG C, is then placed in big iron pan and stir-fries, it is first rear upward downwards, it is firmly uniform, when Gynostemma pentaphylla color starts to turn to be yellow, and starts small fire stir-frying and forms for 20-30 minutes.The gynostemma pentaphylla fried is put into Titian in fragrance extracting machine 30-45 minutes, naturally dry after taking-up.

Other raw materials Cortex Magnoliae Officinalis 1500g, elscholtiza 1500g, herba lysimachiae 1500g, rhizoma imperatae 1500g, Poria cocos 1500g are taken again, it is red Join 1500g, umbellate pore furgus 1500g, eupatorium 1500g, adlay 1500g, herba taxilli 1500g, semen plantaginis 1500g, radices trichosanthis 1500g, it is yellow A kind of reed mentioned in ancient books 1500g, Rhizoma Atractylodis Macrocephalae 1500g, corn stigma 1500g are added in the 5-10 times of ethyl alcohol measured and impregnate 1-2 hours, and heating extraction 2 times, often It is 1-2 hours secondary, supernatant, combined extract are removed, 100-120 mesh filters, then through the ultrafiltration that molecular weight is 5000-10000 of shutting off Column ultrafiltration, ultrafiltrate are concentrated under reduced pressure when relative density is 80 DEG C 1.36 medicinal extract, heat and be concentrated into paste, stand for standby use, in groups Divide 2.Component 1 and component 2 are mixed into economic benefits and social benefits vacuum concentrator, the concentration that relative density is 1.05 when being concentrated into 90 DEG C Liquid, sets 0~5 DEG C of deepfreeze 24 hours；Refrigeration liquid is added to 0.3% filter aid diatomite, filtering, it is true that filtrate is placed in economic benefits and social benefits again In empty inspissator, it is concentrated into every 1ml crude drug amount containing 1g, then plus honey reconciles, and granule is made, mixes the gynostemma pentaphylla of Titian, Ultraviolet disinfection is packed to obtain the final product.

Specific embodiment 3:

The fresh and tender gynostemma pentaphylla 3800g of picked by hand, sunning, parches；The gynostemma pentaphylla dried is put into water-removing pot and goes blueness, It finishes 30-45 minutes at 70-100 DEG C, is then placed in big iron pan and stir-fries, it is first rear upward downwards, it is firmly uniform, when Gynostemma pentaphylla color starts to turn to be yellow, and starts small fire stir-frying and forms for 20-30 minutes.The gynostemma pentaphylla fried is put into Titian in fragrance extracting machine 30-45 minutes, naturally dry took other raw materials Cortex Magnoliae Officinalis 1200g, elscholtiza 1100g, herba lysimachiae 1100g, rhizoma imperatae after taking-up 1200g, Poria cocos 1100g, Radix Salviae Miltiorrhizae 1200g, umbellate pore furgus 1200g, eupatorium 1200g, adlay 1200g, herba taxilli 1100g, semen plantaginis 1100g, radices trichosanthis 1200g, radix scutellariae 1200g, Rhizoma Atractylodis Macrocephalae 1200g, corn stigma 1200g take bulk pharmaceutical chemicals to clean and dry, in 70 DEG C of baking ovens In, 8-12h is dried, taking-up puts in a drying box cooling, crushed 80-100 mesh with pulverizer.By the particulate matter soaking water of sieving In 12 hours, be then placed in extractor heating and boil 1 hour, filter, filtrate is spare；Filter residue adds water, and second of heating boils 45 Minute, it filters, filtrate is spare；Filter residue adds water, and third time heating is boiled half an hour, filters；It filtrate will be combined three times, powder End, which is placed in 70-90% ethyl alcohol, impregnates 1-2 hours, and 60 DEG C -70 DEG C are heated in water-bath, extracts 2h, every 10min stirring one It is secondary, with filtered through gauze, 50-60% ethyl alcohol is added in residue, 60 DEG C -70 DEG C are continued to extract 2h, and every 10min stirring is primary, gauze Filtering merges leaching liquor, is condensed into paste.Then plus honey reconciles, and granule is made, mixes the gynostemma pentaphylla of Titian, ultraviolet light Sterilizing, is packed to obtain the final product.

Specific embodiment 4:

The fresh and tender gynostemma pentaphylla 3000g of picked by hand, sunning, parches；The gynostemma pentaphylla dried is put into water-removing pot and goes blueness, It finishes 30-45 minutes at 70-100 DEG C, is then placed in big iron pan and stir-fries, it is first rear upward downwards, it is firmly uniform, when Gynostemma pentaphylla color starts to turn to be yellow, and starts small fire stir-frying and forms for 20-30 minutes.The gynostemma pentaphylla fried is put into Titian in fragrance extracting machine 30-45 minutes, naturally dry after taking-up.

Other raw materials Cortex Magnoliae Officinalis 1100g, elscholtiza 1100g, herba lysimachiae 1000g, rhizoma imperatae 1100g, Poria cocos 1100g are taken again, it is red Join 1100g, umbellate pore furgus 1200g, eupatorium 1100g, adlay 1100g, herba taxilli 1200g, semen plantaginis 1100g, radices trichosanthis 1200g, it is yellow Surplus stock component is put into 10 times of amount ethyl alcohol, heating and refluxing extraction 2 times by a kind of reed mentioned in ancient books 1100g, Rhizoma Atractylodis Macrocephalae 1100g, corn stigma 1100g, 1~2 hour every time, No. 2 extracting solutions are merged and are stood；The dregs of a decoction for the component raw medicinal material that above-mentioned ethyl alcohol extracted are added 10 times again Amount water heating and refluxing extraction 2 times 1~2 hour every time, No. 2 extracting solutions is merged and are stood；Above two extracting solution is merged, is subtracted Pressure concentration relative density is the filtrate of 1.35 (80 DEG C), recycles ethyl alcohol, by gained filtrate adjustment specific gravity to 1.06, depressurizes to obtain leaching Cream, then plus honey reconciles, and is put into granulator and 1-2 centimetres of granule is made, be condensed into paste or powder is made in convection drying Agent.Mix the gynostemma pentaphylla of Titian, ultraviolet disinfection is packed to obtain the final product.

Pharmacological toxicity test

One, skin irritation test

1, experimental method

Depilatory agent is uniformly coated with by guinea pig back backbone two sides, makes about 20 square centimeters of unhairing range.Clean depilatory agent Cage is returned to observe 24 hours, every group of cavy applies 4,8 and 12g of the present invention respectively, and 92mg containing crude drug, 184mg and 368mg, another respectively Group applies solvent 0.8ml twice a day, continuous one week, after experiment, cavy is put to death, the heart, liver, and kidney and depilation skin do pathology It examines.

2, result

Above-mentioned three groups of medications cavy trunk hair removal section, has no that local skin has oedema, hyperemia, erythema, blutpunkte and ulcer. Medication group cavy chroma of hair is ingested, the control groups no significant difference such as four limbs activity, histopathologic examination, the administration group heart, Liver, kidney and depilation the skin also no significant difference compared with compareing word.

As a result it prompts, the present invention also has no that general toxicity shows without local irritant effect.Show that invention formulation uses peace Entirely.

Two, animal acute toxicity test is studied:

The present invention cannot measure LD50, therefore measure maximum dosage-feeding through trial test.Using rectal delivery, measure small The maximum dosage-feeding on the one of mouse is 62.7g/kg (in terms of medicinal powder), and (people is with 60kg for 1567.5 times of about quasi- clinical people's dosage Meter), the maximum dosage-feeding 62.7g/kg (in terms of medicinal powder) on the one of rat, 1567.5 times of about quasi- clinical people's dosage.Experiment is dynamic Object is observed continuously one week, and appearance sign, the state of mind, diet, drinking-water, excrement etc. are showed no obvious abnormalities.Experiment terminates When, animal health survival, weight gain.

Three, long-term toxicity test for animals is studied:

This test sets the high, medium and low dosage group of drug of the present invention and matrix control group, blank control group, using rectally Approach gives rat, and dosage is respectively 3.2,2.4 and 1.6g/kg (in terms of medicinal powder), is equivalent to quasi- clinical patient dosage 80,60 and 40 times of [0.04g (medicinal powder)/kg], successive administration 2 months, during the administration, each administration group and matrix group rat Weight, dietary amount, appearance signs, behavioral activities, the state of mind, hair color, fecal character compared with blank control group, without obvious Difference (P > 0.05), the weight of animals increasing value and Main Organ Coefficients and blank control group comparing difference be not significant (P > 0.05), Hematology and the individual indexs of blood parameters inspection result administration group and blank control group comparing difference are significant (P < 0.05), but Discrepant hematology and blood parameters have restored normally after convalescence, other indexs and blank control are poor Different not significant (P > 0.05), administration phase and convalescence histological examination high dose group animal main organs are compared with blank control group It has no notable difference, has no that slowness toxicity occurs.

Pharmacological experiment:

Method: it causes diabetic mouse model as research object using streptozotocin (STZ), gavages the present invention of various concentration Decocting liquid 30 days, using blood glucose reduction absolute value and blood glucose reduction percentage as evaluation index, its blood sugar reducing function of comparative study；With high in fat Mass formed by blood stasis mouse is research object, gives gynostemma pentaphylla decocting liquid stomach-filling 30 days, with the total triglyceride of serum (TG) and total cholesterol (TC), Mouse fine motion, vein bore and capillary open number are evaluation index, observe its effect for reducing fat.The result shows that the present invention can be bright It is aobvious to reduce blood-sugar content and TC, TG content in serum.The conclusion display present invention has the work of the decompression of preferable hypoglycemic, activating microcirculation and removing stasis medicinal With can be clinically used for the health care of the diseases such as diabetes and hyperlipemia.

1 material and method

1.1 material

1.1.1 raw material: the present invention adds water to cook, and is prepared into the reagent of the 9g/10ml containing crude drug, by Qingdao university of TCM One preparation section of affiliated hospital provides；Metformin hydrochloride (Shanghai Fahrenheit pharmacy).

1.1.2 animal Kunming mouses 96, half male and half female, weight (22.5 ± 2.4) g are real by University Of Qingdao animal Center offer is provided.

1.1.3 reagent and instrument streptozotocin (STZ) (SERVER company) are purchased from magnificent company.Electronic balance AB204-WO type (Switzerland's plum Teller-support Co., Ltd)；7150 type automatic clinical chemistry analyzer (Japan) of Hitachi.

1.2 method

1.2.1 modeling is with grouping diabetes: animal is bought back, after adaptable fed 1 week, is randomly divided into normal non-diabetic group 8 and experimental group 40, experimental group fasting 12 hours before modeling, modeling is injected using STZ55mg/kg disposable celiac, is given 24 hours survey blood glucose, glucose in urine after medicine, for three days on end, glucose in urine is qualitative +++ more than, blood glucose value is more than 16.5mmol/L, and is continued constant Person is determined as diabetes and is formed.

Modeling success mouse is randomly divided into 5 groups, model control group, melbine group, decocting liquid of the present invention are high, medium and low dense Degree group.Hyperlipidemia: animal is bought back, after adaptable fed 1 week, is randomly divided into normal non-hyperlipidemia group 8 and experimental group 40 Only, experimental group fasting 12 hours before modeling, modeling give 1 week or more containing 3% cholesterol, 25% lard, 5% sodium taurocholate, 3% The high lipoprotein emulsion of propylthio pyrimidine, 1 time a day, continuous 7 days.Modeling success mouse is randomly divided into 5 groups, model control group, two The high, medium and low concentration group of first biguanides group, decocting liquid of the present invention.

1.2.2 administration and measuring method Normal group and model control group (ig isometric physiological saline)；Hydrochloric acid two First biguanides group (ig, 0.20g/kg)；Decocting liquid group (daily ig decocting liquid 2.0g/kg, 3.0g/kg, 4.0g/ of the present invention respectively of the present invention kg).Each group difference gastric infusion, 1 time/d, continuous 30 days.12h fasting before last dose, 2h after administration pluck eye and take blood, with complete Automatic biochemistry analyzer measures blood glucose and blood lipid.

1.2.3 all data of statistical procedures indicate that data are handled using the analysis of SPSS11.5 statistical software with " χ ± S ", If more comparison among groups homogeneity of variance One-way ANOVAs, if heterogeneity of variance rank sum test, organizes interior front and back and compare with pairing t inspection It tests.

2 results

2.1 hypoglycemics are tested as shown in Table 1, and the high, medium and low concentration group of the present invention can significantly reduce hyperglycemia mouse model Blood glucose, compared with model control group, difference is statistically significant (P < 0.05).

Influence (χ ± S) of the decocting liquid of the present invention of table 1 to mouse blood sugar

Note: compared with Normal group, Δ Δ P < 0.01；Compared with model control group, P < 0.01 * P < 0.05, * *；NS, Physiological saline.

2.3 lipid-loweringings are tested as shown in Table 2, and the high, medium and low concentration of decocting liquid of the present invention can be substantially reduced hyperlipemia mice model TC, TG content.

Influence (χ ± S) of the decocting liquid of the present invention of table 2 to lipid of mice

The influence of 2.4 pairs of microcirculations

The influence of table 1, the present invention to mouse fine motion, vein bore and capillary open number

Compared with the control group, (P < 0.01) increased significantly to mouse capillary open number tested group 1；Tested group 2 right Venule bore and capillary open number dramatically increase (P < 0.01)；Tested group 3 to mouse fine motion, vein bore and capillary Vessel open number all has increase (P < 0.01)；Illustrate that test drug can improve microcirculation, there is function of promoting blood circulation to disperse blood clots.

3 discuss

In recent years, with the continuous improvement of people's living standards, the disease incidences such as diabetes, coronary heart disease increasingly increase. Chinese herbal medicine effect is stablized, and few side effects study the Chinese herbal medicine with hypoglycemic antihypertensive effect, can be clinical treatment diabetes, height Pionemia provides more methods.Gynostemma pentaphylla has reducing blood lipid, blood pressure lowering, hypoglycemic, calm, hypnosis, anti-anxiety, antiulcer, resists Fatigue extends cell survival and improves a poor appetite, and builds up resistance, unobstructed stool, antiasthmatic-antitussive, and the hemorrhoid that disappear, weight-reducing, treatment are empty Disease inhibits gall stone to be formed, prevents and treats the multiple efficacies such as glucocorticoid side effect, anti-aging；The present invention promotes body fat generation It thanks and is allowed to balance, to reach reducing blood lipid, reverse the feeding effects such as fatty liver, while to weight-reducing, defaecation, toxin expelling, promoting sleep effect Fruit is definite.Ancients are mostly used it and treat diabete, the diabetes being equivalent in modern medicine.This experiment is verifying its hypoglycemic, lipid-loweringing It acts on and sets, as a result, it has been found that it truly has obvious hypoglycemic, effect for reducing fat.In conclusion the present invention has good hypoglycemic antihypertensive effect, It can be clinically used for the health care of diabetes and hyperlipidemia.

Claims

1. a kind of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea, which is characterized in that various raw materials in the gynostemma pentaphylla hypoglycemic blood pressure depressing health tea Parts by weight include: 10~50 parts of gynostemma pentaphylla, 10~20 parts of Cortex Magnoliae Officinalis, 10~20 parts of elscholtiza, 10~20 parts of herba lysimachiae, rhizoma imperatae 10~20 parts, 10~20 parts of Poria cocos, 10~20 parts of Radix Salviae Miltiorrhizae, 10~20 parts of umbellate pore furgus, 10~20 parts of eupatorium, 10~20 parts of adlay, mulberry It is 10~20 parts parasitic, 10~20 parts of semen plantaginis, 10~20 parts of radices trichosanthis, 10~20 parts of radix scutellariae, 10~20 parts of Rhizoma Atractylodis Macrocephalae, corn stigma 10 ~20 parts.

2. gynostemma pentaphylla hypoglycemic blood pressure depressing health tea according to claim 1, which is characterized in that the gynostemma pentaphylla hypoglycemic antihypertensive health care The parts by weight of various raw materials include: 10~30 parts of gynostemma pentaphylla in tea, and 10~15 parts of Cortex Magnoliae Officinalis, 10~15 parts of elscholtiza, herba lysimachiae 10 ~15 parts, 10~15 parts of rhizoma imperatae, 10~15 parts of Poria cocos, 10~15 parts of Radix Salviae Miltiorrhizae, 10~15 parts of umbellate pore furgus, 10~15 parts of eupatorium, the heart of a lotus seed 10~20 parts of benevolence, 10~20 parts of herba taxilli, 10~20 parts of semen plantaginis, 10~20 parts of radices trichosanthis, 10~20 parts of radix scutellariae, Rhizoma Atractylodis Macrocephalae 10~ 20 parts, 10~20 parts of corn stigma.

3. gynostemma pentaphylla hypoglycemic blood pressure depressing health tea according to claim 1, which is characterized in that the gynostemma pentaphylla hypoglycemic antihypertensive health care The parts by weight of various raw materials include: 10~40 parts of gynostemma pentaphylla in tea, and 10~20 parts of Cortex Magnoliae Officinalis, 10~20 parts of elscholtiza, herba lysimachiae 10 ~20 parts, 10~20 parts of rhizoma imperatae, 10~20 parts of Poria cocos, 10~20 parts of Radix Salviae Miltiorrhizae, 10~20 parts of umbellate pore furgus, 10~20 parts of eupatorium, the heart of a lotus seed 10~15 parts of benevolence, 10~15 parts of herba taxilli, 10~15 parts of semen plantaginis, 10~15 parts of radices trichosanthis, 10~15 parts of radix scutellariae, Rhizoma Atractylodis Macrocephalae 10~ 15 parts, 10~15 parts of corn stigma.

4. a kind of preparation method of the gynostemma pentaphylla hypoglycemic blood pressure depressing health tea as described in claims 1 to 3 any one of item, feature exist In the preparation step of the gynostemma pentaphylla hypoglycemic blood pressure depressing health tea includes:

A. the preparation of gynostemma pentaphylla；

B. the gynostemma pentaphylla Titian fried；

E. the granule of concentration, pulvis or paste are mixed with the gynostemma pentaphylla prepared, sterilizing is prepared into health care medicinal tea.

5. the preparation method of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea according to claim 4, which is characterized in that in the step a, The fresh and tender gynostemma pentaphylla of picked by hand, sunning, parches；The gynostemma pentaphylla dried is put into water-removing pot and goes blueness, at 70-100 DEG C Water-removing 30-45 minutes, is then placed in big iron pan and stir-fries, first rear upward downwards, firmly uniform, when gynostemma pentaphylla color is opened Huang is originated, starts small fire stir-frying and forms for 20-30 minutes.

6. the preparation method of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea according to claim 4, which is characterized in that in the step b, The gynostemma pentaphylla fried is put into fragrance extracting machine Titian 30-45 minutes, naturally dry after taking-up.

7. the preparation method of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea according to claim 4, which is characterized in that in the step c, It takes other raw materials to be added in the 5-10 times of ethyl alcohol measured to impregnate 1-2 hours, it is heating extraction 2 times, 1-2 hours each, supernatant is removed, is closed And extracting solution, the filtration of 100-120 mesh, then through the ultrafiltration column ultrafiltration that molecular weight is 5000-10000 of shutting off, ultrafiltrate is concentrated under reduced pressure 1.36 medicinal extract when relative density is 80 DEG C, heating are concentrated into paste, stand for standby use.

8. the preparation method of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea according to claim 4, which is characterized in that in the step d, By in the medicinal extract merging economic benefits and social benefits vacuum concentrator of concentration, the concentrate that relative density is 1.05 when being concentrated into 90 DEG C sets 0~5 DEG C Deepfreeze 24 hours；Refrigeration liquid is added to 0.3% filter aid diatomite, filtering, filtrate is placed in again in economic benefits and social benefits vacuum concentrator, It is concentrated into every 1ml crude drug amount containing 1g；Paste after concentration adds honey reconciliation that granule is made；Or pulvis is made in convection drying.

9. the preparation method of gynostemma pentaphylla hypoglycemic blood pressure depressing health tea according to claim 4, which is characterized in that in the step e, The gynostemma pentaphylla made is mixed with other raw materials refined, is packed after ultraviolet ray sterilization bactericidal.

10. a kind of preparation method of the gynostemma pentaphylla hypoglycemic blood pressure depressing health tea as described in any one of claims 1 to 3, feature exist It can be in, preparation step are as follows: surplus stock is put into 10 times of amount ethyl alcohol, heating and refluxing extraction 2 times, 1~2 is small every time When, No. 2 extracting solutions are merged and are stood；10 times of amount water are added to heat back the dregs of a decoction for the component raw medicinal material that above-mentioned ethyl alcohol extracted again Stream extracts 2 times, 1~2 hour every time, No. 2 extracting solutions is merged and are stood；Above two extracting solution is merged, is concentrated under reduced pressure opposite Then plus bee 1.35 filtrate when density is 80 DEG C, recycles ethyl alcohol, by gained filtrate adjustment specific gravity to 1.06, depressurizes to obtain medicinal extract, Honey reconciles, and is put into granulator and 1-2 centimetres of granule is made, be condensed into paste or pulvis is made in convection drying.