CN103719495B - A kind of great burdock achene hypoglycemic health protection tea and preparation method thereof - Google Patents

Abstract

The invention provides a kind of great burdock achene hypoglycemic health protection tea, in described great burdock achene hypoglycemic health protection tea, the parts by weight of various raw material are: great burdock achene 10 ~ 50 parts, 10 ~ 20 parts, cultivated land, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, pyrrosia lingua 10 ~ 20 parts, cordate houttuynia 10 ~ 20 parts, paniculate swallowwort 10 ~ 20 parts, sealwort 10 ~ 20 parts.Modern medicine study, great burdock achene can reduce serum total cholesterol and triacylglycerol content, can clear up blood rubbish, impels the metabolism of cells in vivo; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, the most mouthfeel of these medicinal materials is light, does not affect the taste of great burdock achene tea, makes people be easy to accept, more can reach effect of blood lipid-reducing blood sugar-decreasing preferably.

Description

A kind of great burdock achene hypoglycemic health protection tea and preparation method thereof

Technical field

The present invention relates to the hypoglycemic health products containing deriving from plant composition, particularly a kind of great burdock achene hypoglycemic health protection tea and preparation method thereof.

Background technology

Along with industrialized development, the change of dietary structure, the improvement of living condition, the quantity of Overweight and obesity crowd worldwide increases rapidly, and in the trend of becoming younger, become global and have a strong impact on healthy epidemic disease, therefore, search of health effective hypoglycemic method has very real significance, and antihypelipidemic active substance is the key that people expect to solve problem of obesity always safely and effectively.Medical research also shows, Chinese medicine great burdock achene can affect HypercholesterolemicRats, significantly can reduce the cholesterol in serum and liver.There is reducing blood lipid, antibacterial, hypoglycemic, antioxidation, and energy interference body is to the absorption of fat, promotes that the fat taken in excretes.

Hypoglycemic method is a lot, there are dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc. these methods more or less have weak point, what have also easily causes side effect, as diarrhoea, apocleisis etc. and health treatment hypoglycemic has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.

The high speed development of Modern Urban Living, also brings a series of rich man's disease.Wherein " three is high " and obesity are the primary enemies of puzzlement people." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Usually along with obesity.They be modern society derive from " rich man's disease ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three high diseases ".Be what has statistics about three height, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Great burdock achene function: dispelling wind and heat from the body, a surname's lung promoting eruption, subdhing swelling and detoxicating; Antibacterial, hypoglycemic.Purposes: cough due to wind-heat evil, abscess of throat; Rubella is had an itch, and ecchymosis is not saturating; Carbuncle sore tumefacting virus.1, protein " ossein " lifting body inner cell vigor the hardest in human body can be strengthened.2, in vivo chemical reaction occurs, can produce more than 30 kinds materials, wherein " volume folic acid " can prevent human body cell from bad change occurring, and prevents cancer cell from producing.3, promote the propagation of cells in vivo, strengthening and enhancing white blood cell, " blood platelet ", makes T cell with the speed increment of 3 times, reinforced immunological power, promotes anticancer effect.4, impel phosphorus calcium and the balance of vitamin D in combination in body, maintain human body and grow up.5, blood rubbish can be cleared up, impel the metabolism of cells in vivo, prevent aging, make skin beauty careful, can color spot be eliminated, dark brown spot.

The fiber of burdock can promote intestinal peristalsis, helps defecation, reduces body inner cholesterol, and minimizing toxin, refuse accumulate in vivo, reaches prevention of stroke and the effect of preventing and treating cancer of the stomach, the cancer of the uterus.Often edible radix bardanae stimulates circulation, so be applicable to very much the working clan of long-term sitting office.Remove stomach rubbish, prevent human body from crossing presenility, moist skin, preventing apoplexy and hypertension, detoxicating intestine, reduction cholesterol and blood sugar, and be applicable to diabetic's edible (because containing synanthrin in radix bardanae) for a long time, rheumatoid disease, antimycotic have certain curative effect, also good prevention and prohibition effect is had to cancer and uremia, therefore be described as the best hematocathartic of the Nature, Taiwan is among the people using the holy product of burdock as kidney tonifying, establishing-Yang, nourishing.

Present various hypoglycemic health products, medicine spreads unchecked, but great majority are had a good apperance only, false propaganda on a grand scale, probably without any health care, but causes the huge injury of the person, therefore, search of health effective hypoglycemic method has very real significance.Antihypelipidemic active substance is the key that people expect to solve problem of obesity always safely and effectively.Chinese medicine hypoglycemic, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are reducing blood lipid, antibacterial, hypoglycemic, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promote the hypoglycemic product that the fat taken in excretes, and there are health products that are nontoxic, that can be absorbed completely by organism.

Summary of the invention

Technical problem to be solved by this invention is, dragons and fishes jumbled together for most of antihypelipidemic products in present market, false propaganda, probably without any health care, but cause the huge injury of the person, therefore, search of health effective hypoglycemic method has very real significance, and hypoglycemic active material is the key that people expect the high problem of solution three always safely and effectively.Modern medicine study, great burdock achene can reduce serum total cholesterol and triacylglycerol content, promotes the propagation of cells in vivo, strengthening and enhancing white blood cell, and " blood platelet ", makes T cell with the speed increment of 3 times, reinforced immunological power, promote anticancer effect; Impel phosphorus calcium and the balance of vitamin D in combination in body, maintain human body and grow up; Blood rubbish can be cleared up, impel the metabolism of cells in vivo; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medicinal materials is light, do not affect the taste of great burdock achene tea, make people be easy to accept, more can reach effect of blood lipid-reducing blood sugar-decreasing preferably.

For solving above-mentioned technical barrier, the invention provides a kind of great burdock achene hypoglycemic health protection tea, in described great burdock achene hypoglycemic health protection tea, the parts by weight of various raw material are: great burdock achene 10 ~ 50 parts, 10 ~ 20 parts, cultivated land, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, pyrrosia lingua 10 ~ 20 parts, cordate houttuynia 10 ~ 20 parts, paniculate swallowwort 10 ~ 20 parts, sealwort 10 ~ 20 parts.

Described great burdock achene hypoglycemic health protection tea, in great burdock achene hypoglycemic health protection tea described in it, the parts by weight of various raw material can be: great burdock achene 10 ~ 30 parts, 10 ~ 15 parts, cultivated land, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, eupatorium 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, luffa 10 ~ 15 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, pyrrosia lingua 10 ~ 20 parts, cordate houttuynia 10 ~ 20 parts, paniculate swallowwort 10 ~ 20 parts, sealwort 10 ~ 20 parts.

Described great burdock achene hypoglycemic health protection tea, in great burdock achene hypoglycemic health protection tea described in it, the parts by weight of various raw material can also compare: great burdock achene 10 ~ 40 parts, 10 ~ 20 parts, cultivated land, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, Artemisia anomala 10 ~ 15 parts, cassia seed 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, pyrrosia lingua 10 ~ 15 parts, cordate houttuynia 10 ~ 15 parts, paniculate swallowwort 10 ~ 15 parts, sealwort 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of great burdock achene hypoglycemic health protection tea, and the preparation process of described great burdock achene hypoglycemic health protection tea comprises following aspect:

A. the frying of great burdock achene;

B. other raw materials described are extracted 2 times;

C. again by the concentration of liquid medicine that surplus stock extracts, granule is made;

D. the granule prepared is mixed with the great burdock achene prepared, pack after sterilizing.

In described step a, the great burdock achene of results can be cleaned, the airing time, at 7-12 hour, parches; The great burdock achene that airing is good is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 80-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when great burdock achene color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out.

In described step b, surplus stock can be cleaned impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters.

In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds starch or dextrin and puts into granulator and granulate.

In described steps d, great burdock achene good for frying can be mixed with other raw extract granulation particles, ultraviolet disinfection, packs and get final product.

For solving the problems of the technologies described above, the present invention reoffers the preparation method of a kind of great burdock achene hypoglycemic health protection tea, other raw materials of described great burdock achene hypoglycemic health protection tea are made paste preparation process and can also are: surplus stock is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; The dregs of a decoction of the component raw medicinal material crossed by above-mentioned alcohol extract again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; Merged by above-mentioned two kinds of extracts, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, and by gained concentrate adjustment proportion to 1.06, decompression, is condensed into paste.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of great burdock achene hypoglycemic health protection tea, other raw materials of described great burdock achene hypoglycemic health protection tea are made pulvis preparation process and can also are: first described surplus stock medicine is dropped into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, second time adds 4-8 times amount soak by water 1-2 hour, merge twice decocting liquid, filter to get filtrate; Heating is concentrated into pasty state, puts into after 80 DEG C, baking oven is dried and cools, grind to form fine powder.

The technical problem that the present invention solves is, great burdock achene can reduce serum total cholesterol and triacylglycerol content, promotes the propagation of cells in vivo, strengthening and enhancing white blood cell, " blood platelet ", makes T cell with the speed increment of 3 times, reinforced immunological power, promotes anticancer effect; Impel phosphorus calcium and the balance of vitamin D in combination in body, maintain human body and grow up; Blood rubbish can be cleared up, impel the metabolism of cells in vivo; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medicinal materials is light, do not affect the taste of great burdock achene tea, make people be easy to accept, more can reach effect of blood lipid-reducing blood sugar-decreasing preferably.

Detailed description of the invention

Great burdock achene is the seed of burdock, is rich in grease, the many sliding profits of property.Modern pharmacological research shows, burdock main component is arctiin and fat oil, and these compositions have the merit of the ease constipation that relaxes bowel.Great burdock achene is worked hard cold cunning, and the logical lower effect of laxation is comparatively strong, thus is very Gospel to constipation patient.Its two, lung qi falls.The lung is concerned with QI of the whole body, forming an integral part with large intestine.Intestines internal organs leading to falls, and depends on a surname of lung qi respectful.It is respectful that lung loses a surname, then large intestine promotes unable, causes FU QI being obstructed.Therefore defaecation ease constipation first must control lung.Great burdock achene enters lung channel, can fall lung qi.As Zhang Xichun cloud: " the inverse of lung qi can fall in great burdock achene " " perillaseed, burdock can fall inverse by phlegm clearly again, make against cyclostrophic descending " (" Records of Tradition Chinese and Western Medicine in Combination ").With its defaecation ease constipation, there is the wonderful of " carry kettle and take off lid ".Its three, stomach Qi is fallen.Defeated large intestine under the descending then swill of stomach Qi, then becomes stool and excretes.Great burdock achene enters stomach warp, and " pungent hardship of rushing down is fallen, and descending power is many " (" book on Chinese herbal medicine justice "), can fall stomach Qi, have the effect of medicine for stomach dynamic.As Zhang Xichun cloud: " ... therefore help it with the medicine falling stomach again, the ochre in side, dried orange peel, burdock are also " (" Records of Tradition Chinese and Western Medicine in Combination ").In a word, great burdock achene is cold in nature, and taste is worked hard.The heat-clearing of cold energy, under hardship can be rushed down, Xin Nenghang falls apart, and is applicable to the malicious Tianjin of various heat and hinders constipation.As " medicineization justice " cloud: " great burdock achene can rise and can fall, power relieving heat toxin, and bitter can relieve inflammation or internal heat, and is with pungent energy dispelling wind, cures mainly ... all scorchingly hot heap soil or fertilizer over and around the rootss ... ".

" book on Chinese herbal medicine is just ": the use of burdock, energy dispelling wind and heat from the body, rises and sends out an acne rash, and kind leading to defecates, and Gou Feire contains, or the not solid person of temper, and that throws often has loose bowels, then pungent hardship of letting out is fallen, and descending power is many.Clean Gu makes temperature, and Jing Yue calls again during it falls liter, all non-true essence." not Lu " claims its improving eyesight, then wind-heat is let out and order is self-evident.Bowl spares person, also Xing's heat is gone and just certainly pacifies.Except wind the wounded, with wind-heat speech also.Its rhizome, be then on the point of the bitter cold of lake " detailed outline " meaning, and " not Lu " cures mainly, all meanings of heat extraction tonneau.Cover its power, this is close with son, and the property of cold and cool catharsis crosses it, all lets out with heat-clearing and leads as controlling, all non-excess fires, cannot not absurdly throw.All being suitable for of lung heresy reach, but and be unsuitable for the person of falling, as measles from the beginning of, still do not give vent to, early throw and fall clearly, then perseverance has and suppresses mechanism of qi, the anxiety that renvoi caves in.Among only burdock is then let out clearly, self energy is sent out thoroughly, and warm disease, and stool, from logical, also can kill its gesture less, therefore the special medicine of burdock measles the most.Great burdock achene is rich in linoleic acid, rutin, Quercetin, phytosterol, selenium, chromium, manganese.The pathologic lesion to acute pancreatitis can be alleviated; protection pancreatic tissue; strengthen insulin peripheral action; anti peroxidation of lipid; suppress oxidative modification of high density lipoprotein, promote that cholesterol degradation is cholic acid excretion, reduce the permeability of capillary; hemangiectasis, strengthens ascorbic effect and promotes vitamin accumulation in vivo.

Gynostemma pentaphylla finds through modern medicine study, gynostemma pentaphylla principle active component is polysaccharide, flavonoids, saponins and microelement kind, its effect mainly promotes body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (sphagitis, enterogastritis etc.) and health care.

Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Eupatorium expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience summer-heat and damp; Fever and chills are had a headache; Accumulate in moistening; Gastral cavity ruffian is not hungry; N and V; Sweet greasy in mouthful; Disappear truly. " Bencao Jingshu ": lung governing qi, lung qi pent-up, then upper orifices is closed and lower orifices are obstructed, the main Na Shuigu of stomach, stagnation of stomach-QI, then water paddy not with time and be phlegm addiction, fragrant thoroughwort pungent flat can dissipating bind stagnant, fragrance can remove dirty evil, then come up all cards from recover, mostly appetizing is except disliking, and clearing lung-heat dissolving phlegm, the panacea of Disperse hepatic depression also." key medicine divides agent ": fragrant thoroughwort, for dissolving phlegm except disliking, the product of loose Yu Xiejie, "Nei Jing" is quenched one's thirst treating with Herba EuPatorii, and removing the accumulation of stale pathogen is also.Lid is quenched one's thirst by heat symptoms caused by an exopathgen pent-up in stomach, blue energy removing the accumulation of stale pathogen.Known fragrant thoroughwort is solid to cleanse for merit, eliminates stomach person also.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Root tuber of aromatic turmeric is pungent, bitter, cold.Return liver, the heart, lung channel.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice.For through closing dysmenorrhoea, chest and abdomen swelling and pain, shouting pain, pyreticosis coma, epilepsy is gone mad, and jaundice urine is red.Promoting qi circulation and removing obstruction in the collateral, cool blood breaks the stasis of blood.Control all pains of chest abdomen side of body rib, lose the heart demented, pyreticosis coma, spit blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood drenches, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman place vim and vigour pained, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main blood amasss, lower gas, myogenic, hemostasis, and broken extravesated blood, blood drenches, hematuria, metal-inflicted wound.

Luffa, formal name used at school VegetableSpongeofLuffa, cool in nature, taste is sweet.Enter lung, stomach, Liver Channel.Dredging collateral, invigorates blood circulation, and dispels the wind.For the contraction of numbness pain, distending pain in the chest and hypochondrium, alactation." book on Chinese herbal medicine is just read ": luffa, enters channels and collaterals, separates heat symptoms caused by an exopathgen.Heat is removed then wind and is gone, and in network, the unlikely knot of body fluid is combined into phlegm, becomes all diseases of pyogenic infections, therefore cloud removing toxic substances ear.

The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.But table is real evil to be contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst." herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood.”

Cultivated land: cultivated land is the block root of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmanniaglutinosa), has another name called prepared rhizome of rehmannia or throws oneself on the ground, forming through Processing methods.Usually with wine, fructus amomi, dried orange peel for auxiliary material is through repeatedly steaming solarization, to interior exogenic color dirty oil profit, quality softness is sticky.Section use, or fry charcoal use.Cultivated land has another name called prepared rhizome of rehmannia or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese medicine, there is enriching yin effect of enriching blood, can be used for the deficiency of blood sallow, dizzy, palpitation and insomnia, irregular menstruation, the diseases such as uterine bleeding, also diseases such as can be used for hectic fever hectic fever due to yin, the night sweat of the deficiency of the kidney yin, pass out semen, quench one's thirst is one of asthenic symptoms class non-prescribed medicine medicine Liuwei Dihuang Wan main component.

The root bark of white mulberry is the root skin of moraceae plants mulberry MorusalbaL..Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Effect: removing heat from lung and relieving asthma, inducing diuresis for removing edema.Cough for lung heat and breathe heavily, the edema of the face, the diseases such as difficult urination." property of medicine opinion ": make, flat.Can control lung qi breathes heavily full, aqueous vapor edema, and main wound is exhausted, dredging water passages, and disappear aqueous vapor, the headache of consumptive disease visitor heat, interior tonifying for the deficiency." Japan hanako materia medica ": temperature, in tune, lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.

Pyrrosia lingua, latin name: FoliumPyrrosiae.Promoting diuresis for stranguria, clearing lung-heat expels the heat-evil.Control and drench pain, hematuria, lithangiuria, ephritis, uterine bleeding, dysentery, cough with lung heat, chronic bronchitis, metal-inflicted wound, ulcer." not Lu ": " only tired lower gas, logical bladder is full, mends the exhaustion or lesion of the five internal organs, An Wuzang, goes to dislike wind, beneficial vital essence." 9. " book on Chinese herbal medicine is high former ": pyrrosia lingua, cures mainly labor heat evil gas person, labor heat is at bone, and perverse trend is at skin, and the institute of lung kidney is main also.Five infirmity persons, the five liquid retention of urines, difficult urination also.Pyrrosia lingua helps the vital essence of lung kidney, and upper downcrossings, crystal is moistened, then the outer key of upper orifices is all logical, changes, then capable the and little facility of water channel under lung qi.

Fructus Corni, cure mainly perverse trend fever and chills under the heart, Wen Zhong, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing yin essence benefit essence, five viscera settling, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., for China commonly uses rare traditional Chinese medicine, applicating history is long.It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " chinkuei shin chewan pills " with Fructus Corni.According to chemical analysis, Fructus Corni contains the active ingredients such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, anti-inflammatory, the pharmacological action such as antibacterial, is the medicine simply commonly used in tcm clinical practice.

Artemisia anomala it there is hemostasis of curing the wound, broken blood stimulates the menstrual flow, promoting digestion and removing indigestion, be amusing appetizing effect.It can be used for acute icteric hepatitis, toothache, chronic bronchitis, stomatitis, sphagitis, tonsillitis, ephritis, malaria; Eye conjunctivitis is controlled in external application, tympanitis, sore, eczema, traumatism and bleeding.Broken blood stimulates the menstrual flow, healing up sore and subduing swelling.Control through closing abdominal mass, chest and abdomen swelling and pain, postpartum blood stasis, traumatic injury, metal-inflicted wound is hemorrhage, Yong Du inflammation swell.Tang Materia Medica: " main broken blood is lower swollen." " Japan hanako materia medica ": " controls pain in the chest and abdomen, and lower air water is swollen, vim and vigour, logical married woman's passages through which vital energy circulates crux, only cholera watery diarrhea.

Cassia seed removing heat to brighten vision, relaxes bowel.For the puckery pain of hot eyes, the many tear of photophobia, have a headache dizzy, order is secretly failed to understand, constipation.Return liver, kidney, large intestine channel.There is effect of fat-reducing.Control wind-heat cute conjunctivitis, glaucoma, night blindness, hypertension, hepatitis, cirrhotic ascites, habitual constipation.The suitable symptom of cassia seed Herb Tea and crowd: cassia seed can be arranged in pairs or groups with other Herb Teas, have good greasy effect of toxin expelling oil extraction.Can effect be reached: the flat liver of heat-clearing, blood fat-reducing blood pressure-decreasing, relax bowel, improving eyesight benefit eyeball.Modern " TV race ", " cybraian " etc. easily cause the crowd of eye fatigue often to drink, but night preferably drinks less.

Cordate houttuynia cold nature, bitter.Return lung channel, bladder, large intestine channel.Clearing heat and detoxicating; Removing pus and relieving carbuncle; Inducing diuresis for treating strangurtia.Cure mainly: heat drenches main lung carbuncle pyemesis; Phlegm heat panting is coughed; Larynx; Hot dysentery; Carbuncle sore tumefacting virus; Heat is drenched." detailed outline ": malicious carbuncle of dispelling the heat swells, sore hemorrhoid prolapse of the anus ， Duan Malaria disease, separates Nao poison." medical center bun is wanted ": row water, assaults fortified position, goes miasma, relieving summer-heat.Treat snakeworm poison, control beriberi, ulcer of bursting, removes hemostasis.The fresh juice of cordate houttuynia has inhibitory action to staphylococcus aureus, declines after heating. in vitro test proves, cordate houttuynia decoction to multiple gram-positive bacteria and negative bacteria as staphylococcus aureus, staphylococcus albus, hemolytic streptococcus, Diplococcus pneumopniae, micrococcus catarrhalis, corynebacterium diphtheriae, proteus, will is congratulated, Amur, Fu Shi and bacterium sonnei, bacillus enteritidis etc. all have inhibitory action in various degree. and cordate houttuynia ether extract has obvious inhibitory action to tubercle bacillus in vitro. extract a kind of grease obtained in cordate houttuynia, all inhibitory action is had to various microorganism (especially to Molds and yeasts), to hemolytic streptococcus, staphylococcus aureus, Bacillus influenzae, micrococcus catarrhalis, pneumococcus has obvious inhibitory action, also inhibitory action is had to Escherichia coli, shigella dysenteriae, typhoid bacillus. but also have report to think, cordate houttuynia decoction antibacterial action is very unobvious.

Paniculate swallowwort nature and flavor: pungent, temperature.Return Liver Channel, stomach warp.Function: dampness elimination of dispeling the wind, antalgesic-antipruritic.Cure mainly: for arthralgia due to wind-dampness, stomachache turgor, toothache, pain in the back, injury from falling down, nettle rash, eczema.Paniculate swallowwort obviously can increase the intake of mouse cardiac muscle to Rb86, can think and can increase CF, improve myocardial metabolism, alleviate myocardial ischemia.And give paniculate swallowwort continuously 7 days, the myocardium Acute Hypoxic ECG Change caused to rabbit vein instillation pituitrin can not be prevented.Zoopery shows: paniculate swallowwort can reduce the blood pressure of dog, rabbit and rat.The blood pressure of anesthetized animal still can be made in of short duration decline rapidly with the paniculate swallowwort liquid not containing Paeonol, therefore can think, except Paeonol, paniculate swallowwort is still containing other antihypertensive compositions.For feeding, the rabbit experiment hyperlipemia and experimental atherosclerosismodel that cholesterol diet causes is raised to the impact of blood fat, paniculate swallowwort has the effect reducing serum total cholesterol and beta lipoprotein, and atherosclerosis of aorta and parteriole lipid deposition can be alleviated, thus show that paniculate swallowwort has preventive and therapeutic effect to atherosclerotic.

Sealwort is sweet; Taste is put down, and returns spleen; Lung; Kidney channel.Effect boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.Cure mainly: deficiency of Yin labor is coughed; Xeropulmonary cough; Insufficiency of the spleen weak; The few dry of food; Quench one's thirst; Deficiency of the kidney soreness and weakness of waist and knees; Impotence and seminal emission; Tinnitus order is dark; Poliosis; Body void is won thin; Wind favus disease.Sealwort has hypotensive, hypoglycemic, reducing blood lipid, atherosclerosis, and delay senility and effect such as antibacterial grade, Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of lung-kidney deficiency is coughed chronic cough etc.For weakness of the spleen and the stomach.Both tonifying spleen-yin, again beneficial temper, obtain dizzy, soreness and weakness of waist and knees for deficiency of kidney essence, poliosis and quenching one's thirst.

Specific embodiment 1:

First that great burdock achene frying is good.

Again by all the other raw material cultivated lands, Poria cocos, the red sage root, Radix Angelicae Sinensis, the Radix Astragali, eupatorium, gynostemma pentaphylla, the root bark of white mulberry, luffa, Fructus Corni, root tuber of aromatic turmeric, Artemisia anomala, cassia seed, the bighead atractylodes rhizome, pyrrosia lingua, cordate houttuynia, paniculate swallowwort, sealwort extracts concentrated, granulates.

The great burdock achene that mixing frying is good and granule high temperature or the ultraviolet radiation for sterilizing and disinfecting bottling of making particle.

During use, direct boiling water is taken after mixing it with water.

Specific embodiment 2:

Get great burdock achene 5000g to clean, the airing time, at 7-12 hour, parches; The great burdock achene that airing is good is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 80-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when great burdock achene color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out; By surplus stock cultivated land 1500g, Poria cocos 1500g, red sage root 1500g, Radix Angelicae Sinensis 1500g, Radix Astragali 1500g, eupatorium 1500g, gynostemma pentaphylla 1500g, root bark of white mulberry 1500g, luffa 1500g, Fructus Corni 1500g, root tuber of aromatic turmeric 1500g, Artemisia anomala 1500g, cassia seed 1500g, bighead atractylodes rhizome 1500g, pyrrosia lingua 1500g, cordate houttuynia 1500g, paniculate swallowwort 1500g, sealwort 1500g, clean impurity elimination, dry, be ground into particle, soak 1 hour; Soaked bulk drug is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medicinal material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.Then granulate, the great burdock achene that mixing frying is good, in potting bottle, ultraviolet disinfection, packs and get final product, and during use, direct boiling water is taken after mixing it with water.

Specific embodiment 3:

Get great burdock achene 5000g to clean, the airing time, at 7-12 hour, parches; The great burdock achene that airing is good is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 80-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when great burdock achene color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out; By other surplus stock cultivated lands 1200g, Poria cocos 1200g, red sage root 1200g, Radix Angelicae Sinensis 1200g, Radix Astragali 1200g, eupatorium 1200g, gynostemma pentaphylla 1200g, root bark of white mulberry 1300g, luffa 1200g, Fructus Corni 1300g, root tuber of aromatic turmeric 1200g, Artemisia anomala 1300g, cassia seed 1200g, bighead atractylodes rhizome 1200g, pyrrosia lingua 1300g, cordate houttuynia 1300g, paniculate swallowwort 1300g, sealwort 1300g, put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, is dried into powder, the great burdock achene that mixing frying is good, in potting bottle, and ultraviolet radiation for sterilizing and disinfecting.During use, direct boiling water is taken after mixing it with water.

Specific embodiment 4:

Get great burdock achene 4500g to clean, the airing time, at 7-12 hour, parches; The great burdock achene that airing is good is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 80-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when great burdock achene color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out; By other surplus stock cultivated lands 1200g, Poria cocos 1300g, red sage root 1400g, Radix Angelicae Sinensis 1200g, Radix Astragali 1200g, eupatorium 1200g, gynostemma pentaphylla 1200g, root bark of white mulberry 1400g, luffa 1200g, Fructus Corni 1300g, root tuber of aromatic turmeric 1200g, Artemisia anomala 1300g, cassia seed 1200g, bighead atractylodes rhizome 1400g, pyrrosia lingua 1300g, cordate houttuynia 1200g, paniculate swallowwort 1300g, sealwort 1300g, put into 10 times amount ethanol, No. 2 extracts each 1 ~ 2 hour, are merged and leave standstill by heating and refluxing extraction 2 times; The dregs of a decoction of the component raw medicinal material crossed by above-mentioned alcohol extract again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; Merged by above-mentioned two kinds of extracts, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, and by gained concentrate adjustment proportion to 1.06, decompression, is condensed into paste, the great burdock achene that mixing frying is good, in potting bottle, and ultraviolet radiation for sterilizing and disinfecting.During use, direct boiling water is taken after mixing it with water.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD>18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is >42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.

Pharmacological experiment:

1 materials and methods

1.1 material

1.1.1 medicine: the material that preparation method 2 of the present invention is obtained, decocts, is prepared into the reagent containing crude drug 9g/10ml, control group: Metformin hydrochloride (Shanghai Fahrenheit pharmacy).

1.1.2 animal Kunming mouse 96, male and female half and half, body weight (20.5 ± 2.3) g, provides by Qingdao university of TCM animal experimental center.

1.1.3 reagent and instrument: Streptozotocin (STZ) (SERVER company), purchased from magnificent company.Electronic balance AB204-WO type (plum Teller-Tuo Co., Ltd of Switzerland); Hitachi 7150 type automatic clinical chemistry analyzer (Japan).

1.2 method

1.2.1 modeling and grouping

Diabetes: animal is bought back, after adaptability feeds 1 week, be divided into normal non-diabetic group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling adopts the injection of STZ55mg/kg disposable celiac, within after administration 24 hours, survey blood sugar, glucose in urine, for three days on end, glucose in urine is qualitative +++ more than, blood glucose value is more than 16.5mmol/L, and continue constant person, be defined as diabetes and formed.

Modeling success mouse is divided into 5 groups, the high, medium and low concentration group of model control group, melbine group, decocting liquid of the present invention at random.

Hyperlipidemia: animal is bought back, after adaptability feeds 1 week, be divided into normal non-hyperlipidemia group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling gives more than 1 week containing 1% cholesterol, the high lipoprotein emulsion of 20% lard, 2% sodium taurocholate, 1% propylthio pyrimidine, every day 1 time, continuous 7 days.Modeling success mouse is divided into 5 groups, the high, medium and low concentration group of model control group, melbine group, decocting liquid of the present invention at random.

1.2.2 administration and assay method Normal group and model control group (the isopyknic physiological saline of ig); Metformin hydrochloride group (ig, 0.20g/kg); Decocting liquid group of the present invention (ig every day decocting liquid 2.0g/kg of the present invention respectively, 3.0g/kg, 4.0g/kg).Each group of difference gastric infusion, 1 time/d, continuous 30 days.12h fasting before last administration, 2h after administration, plucks eye and gets blood, measures blood sugar and blood fat with automatic clinical chemistry analyzer.

1.2.3 all data of statistical procedures represent with "-χ ± S ", data acquisition SPSS11.5 statistical software analyzing and processing, if compare homogeneity of variance One-way ANOVA between many groups, if heterogeneity of variance rank test, compare and use paired t-test before and after in group.

2 results

As shown in Table 1, the high, medium and low concentration group of decocting liquid of the present invention all significantly can reduce the blood sugar of hyperglycaemia mouse model, compares with model control group, and difference has statistical significance (P<0.05) in 2.1 hypoglycemic experiments.

Table 1 sealwort decocting liquid is on the impact (-χ ± S) of mouse blood sugar

Note: compare with Normal group, △ △ P<0.01; Compare with model control group, * P<0.05, * * P<0.01; NS, physiological saline.

2.3 lipopenicillinase experiment as shown in Table 2, the high, medium and low concentration of decocting liquid of the present invention all obviously can reduce TC, TG content of hyperlipemia mice model, compare with model control group, difference has statistical significance (P<0.05, P<0.01).

Table 2 sealwort decocting liquid is on the impact (-x ± S) of lipid of mice

Note: compare with Normal group, △ △ P<0.01; Compare with model control group, * P<0.05, * * P<0.01; NS, physiological saline.

3 discuss

In recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can provide more method for clinical treatment diabetes, hyperlipidemia.Modern pharmacological research shows, burdock main component is arctiin and fat oil, and these compositions have the merit of defaecation ease constipation.Great burdock achene can reduce serum total cholesterol and triacylglycerol content, can clear up blood rubbish, impels the metabolism of cells in vivo; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, the sweet property of Radix Angelicae Sinensis, the Radix Astragali, sealwort taste is put down, return spleen, lung, kidney channel, have the effect of supplementing qi and nourishing yin, " Japan hanako materia medica " is said: " mending general debility ... beneficial taste, profit cardiopulmonary ".Compendium of Material Medica cloud: " mending all void ... replenishing essence marrow ".Ancients' its treatment diabete multiplex, is equivalent to the diabetes in modern medicine.This experiment, for verifying its hypoglycemic, effect for reducing fat and establishing, found that it truly has obvious hypoglycemic, effect for reducing fat.Astragalus polyose, can reduce the content of the cAMP in liver cell thus hinder phosphorylase to activate and Glycogen synthesis enzyme deactivation, causes that Glycogen synthesis accelerates, Glycogen synthesis slows down, thus reduces blood sugar; Its effect for reducing fat may be relevant with the anti-oxidative damage of astragalus polyose, immunological regulation, suppression inflammatory factor.In sum, great burdock achene, Radix Angelicae Sinensis, sealwort, the Radix Astragali etc. have good hypoglycemic lipid-lowering effect, can be used for treatment diabetes and hyperlipidemia clinically.Experimental result shows, the present invention all has obvious reducing effect to Mouse Weight, fat and serum triglyceride, and can improve microcirculation, and hypoglycemic effect for reducing blood fat has been described.

Claims (8)

1. a great burdock achene hypoglycemic health protection tea, it is characterized in that, described great burdock achene hypoglycemic health protection tea is made up of the bulk drug of following parts by weight: great burdock achene 10 ~ 50 parts, 10 ~ 20 parts, cultivated land, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, pyrrosia lingua 10 ~ 20 parts, cordate houttuynia 10 ~ 20 parts, paniculate swallowwort 10 ~ 20 parts, sealwort 10 ~ 20 parts.

2. great burdock achene hypoglycemic health protection tea according to claim 1, it is characterized in that, described great burdock achene hypoglycemic health protection tea is made up of the bulk drug of following parts by weight: great burdock achene 10 ~ 30 parts, 10 ~ 15 parts, cultivated land, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, eupatorium 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, luffa 10 ~ 15 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, pyrrosia lingua 10 ~ 20 parts, cordate houttuynia 10 ~ 20 parts, paniculate swallowwort 10 ~ 20 parts, sealwort 10 ~ 20 parts.

3. great burdock achene hypoglycemic health protection tea according to claim 1, it is characterized in that, described great burdock achene hypoglycemic health protection tea is made up of the bulk drug of following parts by weight: great burdock achene 10 ~ 40 parts, 10 ~ 20 parts, cultivated land, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, Artemisia anomala 10 ~ 15 parts, cassia seed 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, pyrrosia lingua 10 ~ 15 parts, cordate houttuynia 10 ~ 15 parts, paniculate swallowwort 10 ~ 15 parts, sealwort 10 ~ 15 parts.

4. the preparation method of great burdock achene hypoglycemic health protection tea as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described great burdock achene hypoglycemic health protection tea comprises following aspect:

A. the frying of great burdock achene;

B. other raw materials are extracted 2 times;

C. again by concentration of liquid medicine; Make granule;

D. the granule prepared is mixed with the great burdock achene prepared, pack after sterilizing.

5. the preparation method of great burdock achene hypoglycemic health protection tea according to claim 4, is characterized in that, in described step a, get the great burdock achene obtained and clean, the airing time, at 7-12 hour, parches; The great burdock achene that airing is good is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 80-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when great burdock achene color starts blackout, start little fire stir-fry 30-45 minute shaping; When color becomes pitchy, naturally dry after taking out.

6. the preparation method of great burdock achene hypoglycemic health protection tea according to claim 4, is characterized in that, in described step b, other raw materials are cleaned impurity elimination, dries, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters.

7. the preparation method of great burdock achene hypoglycemic health protection tea according to claim 4, it is characterized in that, in described step c, the filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds starch or dextrin and puts into granulator and granulate.

8. treat the preparation method of great burdock achene hypoglycemic health protection tea according to claim 4, it is characterized in that, in described steps d, the great burdock achene that frying is good mixes with granule, ultraviolet disinfection, packs and get final product.