CN108982195A - A kind of full-automatic immunomagnetic beads method purifying instrument - Google Patents
A kind of full-automatic immunomagnetic beads method purifying instrument Download PDFInfo
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- CN108982195A CN108982195A CN201811009399.4A CN201811009399A CN108982195A CN 108982195 A CN108982195 A CN 108982195A CN 201811009399 A CN201811009399 A CN 201811009399A CN 108982195 A CN108982195 A CN 108982195A
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- 239000011324 bead Substances 0.000 title claims abstract description 55
- 238000000034 method Methods 0.000 title claims abstract description 31
- 238000012360 testing method Methods 0.000 claims abstract description 27
- 238000013519 translation Methods 0.000 claims abstract description 16
- 230000003028 elevating effect Effects 0.000 claims abstract description 8
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000010521 absorption reaction Methods 0.000 claims description 12
- 238000004140 cleaning Methods 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 6
- 230000001174 ascending effect Effects 0.000 claims description 3
- 230000004888 barrier function Effects 0.000 claims description 3
- 230000004907 flux Effects 0.000 claims description 3
- 230000010354 integration Effects 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 abstract description 7
- 238000000605 extraction Methods 0.000 abstract description 4
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 235000013305 food Nutrition 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- -1 filtering Substances 0.000 description 3
- 230000005389 magnetism Effects 0.000 description 3
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- 239000000126 substance Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 231100000678 Mycotoxin Toxicity 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000004186 food analysis Methods 0.000 description 1
- 244000078673 foodborn pathogen Species 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000000447 pesticide residue Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The present invention relates to a kind of full-automatic immunomagnetic beads method purifying instrument (20), including machine shell (1), start-stop button (2), touch screen (3), and pedestal (11), electric box (10), bar magnet component (4), bar magnet sleeve assembly (5), test tube placing modules (6), integral elevating component (7), integral translation component (8), sleeve lifting assembly (9) on the base is set, by the interaction between different structure, realizes the efficiently purifying to sample and enrichment.Full-automatic affine magnetic beads for purifying instrument of the present invention has structure simple, and sample extraction is high-efficient, running precision is high, mechanical stability against short circuit is good, guarantees the reliability of sample pretreatment process, the stability and consistency of testing result.
Description
Technical field
The present invention relates to Food Safety Analysis detection fields, and in particular to a kind of full-automatic immunomagnetic beads method purifying instrument.
Background technique
Food safety detection is the harmful substance detected in food according to state quota, for example heavy metal is residual in food
It stays, pesticide residue, residue of veterinary drug, food-borne pathogens, mycotoxin, the non-edible material from soybeans of illegal addition and abuse food additives
Deng detection.The general flow of food inspection analysis are as follows: acquisition, preparation and the preservation of sample, the pretreatment of sample, ingredient point
Analysis, writes analysis report at analysis data record and arrangement.In whole flow process, the method for constituent analysis is very mature, required
Detecting instrument device category is complete, and automate, intelligence degree it is all higher, especially some large-sized analytic instruments, such as liquid
Matter combined instrument, gas chromatograph-mass spectrometer etc..And the preparation and preservation of sample and the pretreatment of sample are due to being related to a large amount of sample
It crushes, extract, filtering, dilution, extraction, purification, the operating process of a series of complex such as concentration, the object type of food analysis is numerous
More, complicated component, source is different, and purpose, project and the requirement of analysis are also not quite similar, these processes are substantially high artificial at present
Manual operation is completed, and relevant automatic equipment is few, therefore sample treatment occupies the major part in entire analytic process
Manpower and time, and drastically influence the result and efficiency of analysis test.Before a kind of efficiently, easy, quick sample of demand
Reason technology is research hotspot and " bottleneck " problem in contemporary analytical chemistry field.
Immunomagnetic beads are the nanometer materials being combined by Magnetic Microspheres-Carrier and immunoligand.Magnetic Microspheres-Carrier is logical
It is often the magnetic bead with the chemical functional groups such as amino, carboxyl, hydroxyl or sulfydryl, functional group and different immunoligands such as activity egg
White, antibody, antigen, Avidin, biotin etc. combine and form immunomagnetic beads.Magnetic Microspheres-Carrier has the characteristics that superparamagnetism, can
When immunomagnetic beads being made to be placed in magnetic field, its magnetism is shown, when removing from magnetic field, magnetism is eliminated, and immunomagnetic beads disperse again.Coating is anti-
As solid phase carrier, antibody and corresponding antigens thereon occurs specific binding and forms Ag-Ab-magnetic bead the immunomagnetic beads of body
Compound, this compound rapidly to magnetic field movement, separate compound with other substances, reach separation under magnetic fields
The purpose of specific antigen, this separation method have the advantages such as fast detection speed, specificity height, high sensitivity, reproducible.
The magnetism separate method favorable repeatability of immunomagnetic beads, it is easy to operate, it is not required to expensive instrument and equipment, does not influence to be separated biological material
Immune detection can be realized and be automated, for extensive by the biological character and function of material, and the performance special due to magnetic bead
The detection of sample, kinetics are fast compared with traditional immunization detection method, and have bigger solid phase binding surface.
Summary of the invention
A kind of full-automatic immunomagnetic beads method is provided it is an object of the invention to solve the above problem of the existing technology
Instrument is purified, to realize the full-automation of sample treatment, the efficiency of food inspection is not only can be improved in this, saves manpower, Er Qieneng
Guarantee the reliability and stability of sample pretreatment process, to guarantee the consistency of testing result.
To achieve the above object, the present invention proposes the following technical solution: a kind of full-automatic immunomagnetic beads method purifying instrument
(20), including machine shell (1), start-stop button (2), touch screen (3) and pedestal (11), electric box on the base is set
(10), bar magnet component (4), bar magnet sleeve assembly (5), test tube placing modules (6), integral elevating component (7), integral translation group
Part (8), sleeve lifting assembly (9), it is characterised in that integral elevating component (7) drives integral translation component under motor driven
(8), bar magnet component (4), bar magnet sleeve assembly (5), sleeve lifting assembly (9) complete whole ascending motion；Integral translation group
Part (8) completes whole put down with moving sleeve lifting assembly (9), bar magnet component (4), bar magnet sleeve assembly (5) under motor driven
Shifting movement carries out multiple reciprocating motion；Sleeve lifting assembly (9) can carry out upper and lower reciprocating motion, realize magnetic bead absorption,
Mix, separate, cleaning and etc..
Preferably, the bar magnet component (4) be using building block assembling the bar magnet equipped with more high magnetic fluxs, it can be achieved that
Oscilaltion and left and right translational motion.
Preferably, the bar magnet sleeve assembly (5) is the molding plastic barrier sleeve of integration, can oscilaltion and a left side
The absorption and separation of magnetic bead are realized in right translation, cooperation bar magnet component (4).
Preferably, fixed test tube position and pallet apparatus, the test tube are set on the test tube placing modules (6)
Item is equipped with 1 sample tube, 4 cleaning pipes, 1 magnetic bead pipe, 1 collecting pipe.
Preferably, the bar magnet component (4) can protrude into bar magnet sleeve assembly (5) bottom.Under bar magnet sleeve assembly (5)
Hold radian consistent with the radian of bottom in each pipe of test tube placing modules (6), to realize efficient mixing, absorption, separation.
Preferably, the touch screen (3) is the human-computer dialogue that carries out of touch, simple to operate.
Beneficial effects of the present invention:
It is using bar magnet component cooperation bar magnet sleeve assembly that magnetic bead is mobile 1. full-automatic immunomagnetic beads method purifying instrument extracts sample
In different pipes on to test tube item, realize quickly stirring, mix, cleaning and etc., be finally reached the sample of high-purity；
The full-automation of sample treatment not only can quickly improve purification efficiency, and running precision is high and mechanical stability against short circuit is good, guarantees
The reliability of sample pretreatment process, the stability and consistency of testing result.
Detailed description of the invention
Fig. 1 is the schematic diagram for the overall appearance that full-automatic immunomagnetic beads method purifies instrument
Fig. 2 is the schematic diagram of internal structure that full-automatic immunomagnetic beads method purifies instrument
Description of symbols
The full-automatic immunomagnetic beads method purifying instrument of 20-, 1- machine shell, 2- start-stop button, 3- touch screen, 11- pedestal, 10- are electrical
Case, 4- bar magnet component, 5- bar magnet sleeve assembly, 6- test tube placing modules, 7- integral elevating component, 8- integral translation component,
9- sleeve lifting assembly.
Specific embodiment
Below with reference to the embodiments and with reference to the accompanying drawing the technical solutions of the present invention will be further described.
Embodiment 1: full-automatic immunomagnetic beads method purifies instrument, as illustrated in fig. 1 and 2, including machine shell (1), start-stop button
(2), electric box (10), bar magnet component (4), bar magnet sleeve assembly on the base is arranged in touch screen (3) and pedestal (11)
(5), test tube placing modules (6), integral elevating component (7), integral translation component (8), sleeve lifting assembly (9), feature
It is that integral elevating component (7) drives integral translation component (8), bar magnet component (4), bar magnet sleeve assembly under motor driven
(5), sleeve lifting assembly (9) completes whole ascending motion；Integral translation component (8) band moving sleeve under motor driven is gone up and down
Component (9), bar magnet component (4), bar magnet sleeve assembly (5) complete whole translational motion, carry out multiple reciprocating motion；Sleeve
Lifting assembly (9) can carry out upper and lower reciprocating motion, realize the absorption of magnetic bead, mixing, separation, cleaning.
Bar magnet component (4) is the bar magnet equipped with more high magnetic fluxs using building block assembling, it can be achieved that oscilaltion and a left side
Right translation campaign.
Bar magnet sleeve assembly (5) is the molding plastic barrier sleeve of integration, can oscilaltion and left and right translation, cooperate magnetic
The absorption and separation of rod assembly (4) realization magnetic bead.
Fixed test tube position and pallet apparatus are set on test tube placing modules (6), the test tube item is equipped with 1 sample
This pipe, 4 cleaning pipes, 1 magnetic bead pipe, 1 collecting pipe.
In addition, bar magnet component (4) can protrude into bar magnet sleeve assembly (5) bottom.The lower end radian of bar magnet sleeve assembly (5) with
The radian of bottom is consistent in each pipe of test tube placing modules (6), to realize efficient mixing, absorption, separation.
Touch screen (3) is the human-computer dialogue that carries out of touch, simple to operate.
Specifically, integral translation component (8) under motor driven band moving sleeve lifting assembly (9), bar magnet component (4),
Bar magnet sleeve assembly (5) completes whole translational motion, and guarantees bar magnet component (4) always in bar magnet sleeve assembly (5)
Position directly above, by carrying out sleeve lifting assembly (9), bar magnet component (4) is inserted into bar magnet sleeve assembly (5), can
Carry out multiple reciprocating motion；The magnetic bead pipe of test tube placing modules (6) is moved to bar magnet component and bar magnet sleeve assembly (5)
When top, by the driving effect of bar magnet sleeve assembly, make the mixing for realizing magnetic bead, bar magnet component (4) is inserted into bar magnet sleeve group
In part (5), so that magnetic bead is adsorbed onto bar magnet and put on, realizes the complete absorption to magnetic bead, be moved to the sample of test tube placing modules (6)
It in this pipe, by the driving effect of bar magnet component (5), back and forth stirs and evenly mixs, sleeve lifting assembly (9) can carry out high speed up and down
It moves back and forth, realizes absorption, mixing, separation of magnetic bead etc..The collection rate of magnetic bead can be improved in this, and then improves the effect for extracting sample
Rate and purity.
A kind of specifically used method of full-automatic immunomagnetic beads method purifying instrument of embodiment 2, to extract the poison of the vomiting in feed
For element:
(1) Feed Sample for weighing 2.5g crushing, is fitted into the centrifuge tube of 5 mL, specific sample diluting liquid is added, is placed on
Oscillator vibrates 20 minutes, centrifuging and taking supernatant, as sample extraction liquid；
(2) it tears the protective film on test tube item off, is put into full-automatic immunomagnetic beads method purifying instrument test tube bar assembly, in sample tube
Sample extraction liquid is added；
(3) in the magnetic bead storehouse of bar magnet set insertion test tube item, purifying instrument by full-automatic immunomagnetic beads method covers bar magnet in magnetic bead storehouse
Middle generation vibration, bar magnet are inserted into bar magnet set, are then inserted into magnetic bead pipe with bar magnet set instrument, and bar magnet adsorbs magnetic bead, then with
Magnetic bead is inserted into sample tube together, and bar magnet is removed；
(4) after sample absorption terminates, bar magnet set is come out respectively with magnetic bead from sample tube successively sequentially into subsequent
Cleaning pipe in cleaned, when being cleaned in each cleaning pipe, bar magnet set moves up and down, vibrate sample and cleaning solution into
Row adequately washing；
(5) after the completion of washing, bar magnet set plays in insertion collecting pipe with magnetic bead one.Be placed with eluent in collecting pipe, bar magnet from
Bar magnet set is opened, bar magnet set moves up and down, so that sample is adequately contacted with eluent.After the completion of oscillation, bar magnet enters bar magnet set,
Magnetic bead is taken back magnetic bead pipe, then bar magnet set and bar magnet return to initial position.Sample stays in collecting pipe, reaches and extracts sample
Purpose.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (6)
1. a kind of full-automatic immunomagnetic beads method purifying instrument (20), including machine shell (1), start-stop button (2), touch screen (3), and
Electric box (10), bar magnet component (4), bar magnet sleeve assembly (5), test tube placing modules on the base is arranged in pedestal (11)
(6), integral elevating component (7), integral translation component (8), sleeve lifting assembly (9), it is characterised in that integral elevating component (7)
Drive integral translation component (8), bar magnet component (4), bar magnet sleeve assembly (5), sleeve lifting assembly (9) complete under motor driven
Integral ascending motion；Integral translation component (8) under motor driven band moving sleeve lifting assembly (9), bar magnet component (4),
Bar magnet sleeve assembly (5) completes whole translational motion, carries out multiple reciprocating motion；Sleeve lifting assembly (9) can carry out
Under reciprocating motion, realize the absorption of magnetic bead, mixing, separation, cleaning.
2. a kind of full-automatic immunomagnetic beads method according to claim 1 purifies instrument, it is characterised in that the bar magnet component
It (4) is the bar magnet equipped with more high magnetic fluxs using building block assembling, it can be achieved that oscilaltion and left and right translational motion.
3. full-automatic immunomagnetic beads method according to claim 1 purifies instrument, it is characterised in that the bar magnet sleeve assembly
(5) be the molding plastic barrier sleeve of integration, can oscilaltion and left and right translation, cooperation bar magnet component (4) realize magnetic bead
Absorption and separation.
4. a kind of full-automatic immunomagnetic beads method according to claim 1 purifies instrument, it is characterised in that the test tube item is put
It sets and sets fixed test tube position and pallet apparatus on component (6), the test tube item is equipped with 1 sample tube, 4 cleaning pipes, 1
A magnetic bead pipe, 1 collecting pipe.
5. a kind of full-automatic immunomagnetic beads method according to claim 1 or 2 or 3 purifies instrument, it is characterised in that the magnetic
Rod assembly (4) can protrude into bar magnet sleeve assembly (5) bottom,
The lower end radian of bar magnet sleeve assembly (5) is consistent with the radian of bottom in each pipe of test tube placing modules (6), with reality
It is now efficient to mix, absorption, separate.
6. a kind of full-automatic immunomagnetic beads method according to claim 1 purifies instrument, it is characterised in that the touch screen (3)
It is simple to operate for the human-computer dialogue that carries out of touch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811009399.4A CN108982195A (en) | 2018-08-31 | 2018-08-31 | A kind of full-automatic immunomagnetic beads method purifying instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811009399.4A CN108982195A (en) | 2018-08-31 | 2018-08-31 | A kind of full-automatic immunomagnetic beads method purifying instrument |
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| CN108982195A true CN108982195A (en) | 2018-12-11 |
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| CN201811009399.4A Pending CN108982195A (en) | 2018-08-31 | 2018-08-31 | A kind of full-automatic immunomagnetic beads method purifying instrument |
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Cited By (5)
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| CN110327659A (en) * | 2019-07-19 | 2019-10-15 | 天津迪沃特生物电子科技有限公司 | A kind of extraction and purification method and device based on magnetic fiber material |
| WO2020186601A1 (en) * | 2019-03-15 | 2020-09-24 | 深圳市易瑞生物技术股份有限公司 | Detection pretreatment device |
| CN113908588A (en) * | 2021-09-23 | 2022-01-11 | 深圳逗点生物技术有限公司 | Full-automatic solid phase extraction instrument |
| CN114371063A (en) * | 2021-12-23 | 2022-04-19 | 苏州睿康生物科技有限公司 | Full-automatic magnetic solid phase extraction device |
| CN116008531A (en) * | 2021-10-21 | 2023-04-25 | 中检国研(北京)科技有限公司 | Magnetic bead purifying instrument |
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| CN110327659A (en) * | 2019-07-19 | 2019-10-15 | 天津迪沃特生物电子科技有限公司 | A kind of extraction and purification method and device based on magnetic fiber material |
| CN113908588A (en) * | 2021-09-23 | 2022-01-11 | 深圳逗点生物技术有限公司 | Full-automatic solid phase extraction instrument |
| CN116008531A (en) * | 2021-10-21 | 2023-04-25 | 中检国研(北京)科技有限公司 | Magnetic bead purifying instrument |
| CN114371063A (en) * | 2021-12-23 | 2022-04-19 | 苏州睿康生物科技有限公司 | Full-automatic magnetic solid phase extraction device |
| CN114371063B (en) * | 2021-12-23 | 2023-10-20 | 苏州睿康生物科技有限公司 | Full-automatic magnetic solid phase extraction device |
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