CN108939284A - It can dissolve microneedle injection device - Google Patents
It can dissolve microneedle injection device Download PDFInfo
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- CN108939284A CN108939284A CN201810933522.5A CN201810933522A CN108939284A CN 108939284 A CN108939284 A CN 108939284A CN 201810933522 A CN201810933522 A CN 201810933522A CN 108939284 A CN108939284 A CN 108939284A
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- push rod
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- micropin
- storage container
- water storage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The present invention relates to a kind of dissolvable microneedle injection devices, including propulsion device, injected substrate and dripping device, injected substrate is for fixing injection micropin film, micropin film includes the micropin on microneedle substrate and microneedle substrate, micropin film is fixed on the back side of injected substrate, injected substrate porous or water suction, propulsion device is for pushing injected substrate that micropin is pierced into position to be injected, dripping device to injected substrate for dripping, aqueous solution absorbs the microneedle substrate of aqueous dissolution micropin film through the microneedle substrate or injected substrate of injected substrate dissolution micropin film.The beneficial effects of the present invention are: solvable micropin film is connect with porous or the injected substrate of water suction, after micropin is pierced into skin, the microneedle substrate connecting with injected substrate is dissolved by dripping device, and the micropin after separating continues to keep in skin controllably dissolution and discharges internal active material, realizes the microneedle injection administration of exact dose.
Description
Technical field
The present invention relates to a kind of dissolvable microneedle injection devices.
Background technique
Percutaneous dosing to avoid macromolecule due to that can degrade in gastrointestinal tract and easy to use, as being used for drug delivery
Effective way and be widely used.In the past in order to make effective component subcutaneously play pharmacological action, used comprising drug effect at
The external preparation divided.As such external preparation, it is known to which liquor, ointment, cream preparation, tape preparation, patch, mud apply
Agent etc., by the way that they are locally coated with or are attached, effective component percutaneous absorbtion is subcutaneously playing desired pharmacological action.
However, the external preparation of above-mentioned coating or attaching form has the following disadvantages: the barriers function due to skin, effective component cannot
By fully percutaneous absorbtion, desired pharmacological action cannot be played.It is difficult especially when effective component is high-molecular compound
With percutaneous absorbtion, it is difficult to play desired pharmacological action in external preparation.And in use, due to perspiration, cleaning, outside
Portion's pressure etc., effective component fall off sometimes or disappear before by percutaneous absorbtion.In recent years, added with the micropin of effective component
Microneedle array as the technology for solving above-mentioned external preparation disadvantage, be widely studied.For example, Publication No. 102580232A
Chinese patent discloses the mainly scheme by fibroin albumen as the microneedle array of micropin raw material.By the way that micropin is pierced into skin table
Layer and/or keratoderma, to supplying the effective component in micropin to subcutaneous, the micropin part of piercing can be subcutaneously molten
It solves or is biodegradable to disappear.In addition, micropin is since needle portion is very thin, thus even if being pierced into skin surface and/or skin
Cuticula does not generate pain or bleeding yet, and punctures and hurt rapid closing, thus is suitable for subcutaneously supplying effective component
Method.Such microneedle array needs to carry out most suitable design according to skin symptom, and it is various micro- to need to develop offer
Needle array.The micropin used as external preparation, which needs synthetically to have concurrently (1), can tolerate to skin surface and/or keratoderma
The intensity of piercing, (2) in order to do not generated in the part for being pierced into skin surface and/or keratoderma the fineness of pain or bleeding with
Flexibility and (3) are pierced into subcutaneous micropin part dissolubility in vivo or biological degradability etc..In the past, such micropin was thin
The substrate of film is using hard material as micropin, and micropin can not be separated with substrate, after micropin is pierced into skin,
Hard substrate must be pressed in skin surface, and after the completion of waiting drug injection, just peelable substrate, brings not to user in this way
It is suitable.
Summary of the invention
The technical problems to be solved by the present invention are: the substrate of existing micropin film and micropin be it is integrated, in micropin
After being pierced into skin, hard substrate must be pressed in skin surface, and after the completion of waiting drug injection, just peelable substrate, gives in this way
User brings discomfort, and the rate of release and drugloading rate of drug not easy to control.
The technical solution adopted by the present invention to solve the technical problems is: a kind of dissolvable microneedle injection device, including pushes away
Into device, injected substrate and dripping device, for injected substrate for fixing injection micropin film, micropin film includes microneedle substrate
With the micropin on microneedle substrate, micropin film is fixed on the back side of injected substrate, injected substrate porous or water suction, propulsion device
For pushing injected substrate that micropin is pierced into position to be injected, dripping device to injected substrate for dripping, and aqueous solution is through note
The microneedle substrate or injected substrate of penetrating substrate dissolution micropin film absorb the microneedle substrate of aqueous dissolution micropin film.
It further limits, injected substrate is separately formed by permeable or water absorbent sheet, and permeable passes through the permeable of permeable on piece
Hole carry out it is permeable, water absorbent sheet by can water-absorption material texture at alternatively, injected substrate is the assembly of permeable and water absorbent sheet, water suction
Piece is located at the permeable back side.
It is preferred that the permeable back side has the flow-guiding channel communicated with permeable hole, it is uniform to will transmit through permeable aqueous solution
It is guided to entire microneedle substrate.
It further limits, propulsion device includes push rod, and injected substrate is mounted on the front end of push rod, has in push rod and lead to note
The push rod channel of substrate front side is penetrated, dripping device is set up directly in push rod channel, alternatively, dripping device is directly logical using push rod
The aqueous solution pumped out is infused the front to injected substrate by road, alternatively, dripping device has the weep pipe in insertion push rod channel, is dripped
The outlet end of pipe is located at the top for closing on injected substrate, and the aqueous solution pumped out infuses the front to injected substrate by weep pipe.
It further limits, the water outlet of weep pipe is blocked by flexible flaps, and water outlet is made to be in normally off, elastic valve
Piece is open in the pressure of the aqueous solution pumped out, flows out aqueous solution by water outlet, alternatively, the water outlet of weep pipe is using straight
The lesser water outlet of diameter.
It further limits, the closing of the water outlet of weep pipe, sealing surface is separated out more pieces of resilient by the cut-off rule intersected
Limb.
Further limit, there are several types of concrete schemes for dripping device: dripping device includes water storage container and water storage container
Interior piston, dripping device pump out the aqueous solution in water storage container by piston；Alternatively, dripping device includes water storage container, storage
The compressible deformation of water container, dripping device pump out the aqueous solution in water storage container by way of compressing water storage container；Alternatively, drop
Water installations include water storage container and thorn stick, and water storage container has the closed upper and lower port of sealer by that can puncture, dripping device
Flow out the aqueous solution in water storage container in such a way that thorn stick pierces through the sealer of the upper and lower port of water storage container from top to bottom.
It further limits, propulsion device further includes that outer tube, power spring and injection switching mechanism, push rod are located at outer tube
Interior, push rod is locked in initial position by injecting switching mechanism, injects switching mechanism by operation, unlocks push rod, push rod exists
Decline under the action of power spring, pushes injected substrate that micropin is pierced into position to be injected, dripping device is by power spring
Power completes to drip movement or dripping device drips movement by the operating force completion of operation injection switching mechanism.
It further limits, injection switching mechanism includes the fixed switch deck of the inner wall of opposite outer tube, has on push rod
Switch buckle and unlocking mechanism, when push rod rises to initial position, the switch buckle of push rod blocks switch deck, by push-rod lock
Due to having unlocking mechanism on initial position, outer tube, unlocking mechanism pull switch buckle is detached from switch card seat, makes push rod solution
Lock.
Further limit, unlocking mechanism is the side press-key of outer tube side, the setting position of side press-key and quantity with
The position of switch buckle is consistent with quantity, by pressing side press-key, acts on out with making the inner end ecto-entad of side press-key
The outside of outpost button, pull switch buckle are deformed inwardly until being detached from switch card seat.
Alternatively, unlocking mechanism is the end key of outer tube rear end, top button is inserted into the rear end of outer tube, and top is pressed
The lower part of key has downwardly projecting lower edge, by pressing down on end key, makes the work of the lower edge of end key from top to bottom
For the outside of switch buckle, pull switch buckle is deformed inwardly until being detached from switch card seat.
It further limits, when dripping device includes the piston in water storage container and water storage container, water storage container and piston
Cover on push rod, the inner cavity of water storage container is communicated with the push rod channel of push rod, water storage container and push rod secure fit, piston with push away
Bar is slidably matched, and piston has piston push piece protruding upward towards injected substrate on the inner wall of outer tube, piston push piece is located at
The lower section of piston, when declining under the action of push rod is in power spring, piston push piece plays barrier effect to piston, pushes piston pump
Aqueous solution.
Alternatively, the lower section of end key is arranged in water storage container when dripping device is the water storage container of compressible deformation,
When pressing down on top button unlock push rod, key compression water storage container in end pumps out aqueous solution.
Alternatively, thorn stick is inserted into push rod channel, the rear end and end of thorn stick when dripping device includes water storage container and thorn stick
By key connection, water storage container is located at the lower part in push rod channel, and when pressing down on end key unlock push rod, end key is driven
Thorn stick pierces through the sealer of the upper and lower port of water storage container from top to bottom, flows out the aqueous solution in water storage container.
It further limits, the side of outer tube also has movable push piece, and movable push piece can be assemblied in housing up and downly
The inner end of Guan Shang, movable push piece act on push rod, are moved up by operant activity push piece, drive the inner end of movable push piece
Push rod overcomes the spring force of power spring to move down, until the switch buckle of push rod blocks switch deck.
It further limits, unlocking mechanism elastic reset.
The beneficial effects of the present invention are: solvable micropin film is connect with porous or the injected substrate of water suction, in micropin
After being pierced into skin, the microneedle substrate connecting with injected substrate is dissolved by dripping device, and the micropin after separating continues to keep skin
Controllably dissolution discharges internal active material in skin, realizes the microneedle injection administration of exact dose.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples；
Fig. 1 is the diagrammatic cross-section that the embodiment of the present invention 2 is in injection preparation state.
Fig. 2 is the diagrammatic cross-section that the embodiment of the present invention 2 is in injection completion status.
Fig. 3 is the external structure schematic diagram of the embodiment of the present invention 3.
Fig. 4 is the diagrammatic cross-section that the embodiment of the present invention 3 is in injection preparation state.
Fig. 5 is the explosive view of the embodiment of the present invention 3.
Fig. 6 is the explosion sectional view of the embodiment of the present invention 3.
Fig. 7 is the structural schematic diagram of the dripping device of the embodiment of the present invention 3.
Fig. 8 is the frontal state structural schematic diagram of the injected substrate of the embodiment of the present invention 3.
Fig. 9 is the back side surface state structural schematic diagram of the injected substrate of the embodiment of the present invention 3.
Figure 10 is the external structure schematic diagram of the embodiment of the present invention 4.
Figure 11 is that the embodiment of the present invention 4 is in the diagrammatic cross-section before injection prepares.
Figure 12 is that the embodiment of the present invention 4 is in the diagrammatic cross-section in injection process.
Figure 13 is the explosive view of the embodiment of the present invention 4.
Figure 14 is the explosion sectional view of the embodiment of the present invention 4.
Figure 15 is permeable frontal state structural schematic diagram of the injected substrate of the embodiment of the present invention 3.
Figure 16 is permeable back side surface state structural schematic diagram of the injected substrate of the embodiment of the present invention 3.
In figure, 1. micropin films, 2. injected substrates, 2-1. permeable, 2-1-1. permeable hole, 2-1-2. flow-guiding channel, 2-
2. water absorbent sheet, 3. push rods, 3-1. push rod channel, 4-1. weep pipe, 4-2. water storage container, 4-3. piston, 4-4. thorn stick, 4-5. envelope
Film, 5. outer tubes, 6. power springs, 7. switch decks, 8. switch buckles, 9. side press-keys, 10. end keys, 11. activities push away
Part, 12. piston push pieces, 13. water inlets, 14. insurance sealing bars, 15. flange collars.
Specific embodiment
Embodiment 1:
A kind of dissolvable microneedle injection device, including propulsion device, injected substrate 2 and dripping device, injected substrate 2 are used for
Fixed injection micropin film 1, micropin film 1 include the micropin on microneedle substrate and microneedle substrate, and micropin film 1 is fixed on note
The back side of substrate 2 is penetrated, injected substrate 2 is the assembly of permeable 2-1 and water absorbent sheet 2-2, and water absorbent sheet 2-2 is located at permeable 2-1
The back side.Permeable 2-1 is carried out permeable by the permeable hole 2-1-1 on permeable 2-1, and water absorbent sheet 2-2 is by can water-absorption material texture
At.For pushing injected substrate 2 that micropin is pierced into position to be injected, dripping device is used to drip to injected substrate 2 propulsion device,
Through being absorbed after permeable 2-1 of injected substrate 2 by water absorbent sheet 2-2, the aqueous solution that water absorbent sheet 2-2 absorbs quickly dissolves aqueous solution
The microneedle substrate of micropin film 1 makes micropin stay in skin so that the microneedle substrate of the micropin for being pierced into skin and top be separated
It is interior, accurately discharge the drug of solvable dosage.
It is preferred that soluble micropin film 1 is fixed in injected substrate 2 by binder, binder can be viscous for soluble-type
Agent is tied, can dissolve viscose glue as made of the excipient substances such as albumen or starch, such as albumen viscose glue and paddy, wheat, corn, horse
Amylan made of bell potato.
Permeable 2-1 and water absorbent sheet 2-2 can be made of hydrophilic material, such as polyvinyl acetate substrate, ethyl vinyl acetate second
In addition alkene copolymer substrate, water-absorbing sponge piece, superabsorbent fibrous material etc. can stamp many on permeable 2-1 and water absorbent sheet 2-2
Small permeable hole, to increase permeable speed and permeable amount.
Aqueous solution can be pure water solution, be also possible to the pharmaceutical aqueous solution comprising drug ingedient, or include beauty
Hold the beauty aqueous solution of skin care ingredient.Aqueous solution containing drug ingedient or beauty and skin care ingredient, after being dissolved with micropin
The micropore left penetrates into skin together, for example aqueous solution is water laser accunputure injection cosmetically, and water laser accunputure injection is molten with micropin
The micropore left after solution penetrates into skin together, plays cosmetic result.
Propulsion device is push rod 3, and injected substrate 2 is mounted on the front end of push rod 3, has in push rod 3 and leading to injected substrate 2 just
The aqueous solution pumped out is directly infused the front to injected substrate 2 using push rod channel 3-1 by the push rod channel 3-1 in face, dripping device,
Microneedle injection is entered into human body by way of manually pushing push rod.
Dripping device includes the piston 4-3 in water storage container 4-2 and water storage container 4-2, and dripping device is pumped by piston 4-3
Aqueous solution in water storage container 4-2 out.
Micropin film is made of biodegradable micropin material, added in biodegradable micropin material it is a kind of or
The active material of a variety of medical treatment or beautifying use.
A kind of preparation method of micropin membrane system, micropin membrane system includes micropin film 1 and injected substrate 2, is had
Following steps:
1) micropin female mold is made；
2) micropin body pre-polymer solution is filled up in the micropin slot of micropin female mold and is solidified；
Step 2 specifically: by the pressing of micropin female mold on the plate of micropin material for being coated with liquid, make micropin female mold
Micropin slot in fill up micropin body pre-polymer solution, the solidification of micropin body pre-polymer solution is moved back except plate, in micropin female mold
Leave the micropin after solidifying；Alternatively, directly the micropin material of liquid is coated in micropin female mold, plate pressing is then reused
In micropin female mold, make to fill up micropin body pre-polymer solution in the micropin slot of micropin female mold, micropin body pre-polymer solution is solid
Change is moved back except plate, and the micropin after solidifying is left in micropin female mold；
3) water absorbent sheet 2-2 is two-sided coats viscose glue, is sticked on permeable 2-1 on one side, glues be pressed in micropin female mold on one side
On the microneedle substrate of the micropin film 1 of cured forming；
4) the soluble micropin film 1 being bonded on water absorbent sheet 2-2 is detached from micropin female mold together, is obtained soluble
Micropin membrane system.
Biodegradable micropin material can be selected from fibroin albumen, collagen, gelatin, hydrogel, carboxymethyl cellulose,
Hydroxypropyl methyl cellulose, chondroitin sulfate, glycogen, dextrin, amylose, hyaluronic acid, polylactic-co-glycolic acid,
Poly lactide-glycolide acid, polyethanol ester, polyacrylic acid, polypropylene, polycarbonate, polystyrene, polyethylene, polychlorostyrene
Ethylene, ABS plastic (acrylonitrile-butadiene-styrene copolymer), dimethyl silicone polymer, Kynoar, acetate fiber,
Polyester, polyurethane, poly- dioxy ring ethyl ketone, poly(ethylene glycol), poly- (lactic acid), polyacrylamide polymer, cycloolefin copolymer close
Object, carboxymethyl chitosan, Poly L-lactic acid, alginic acid, glucan, dextran sulfate, hydroxypropyl methyl cellulose, chitin,
Polyvinylpyrrolidone, lactose, galactolipin, trehalose, sucrose, maltose, glucan, glucosides, fructose, chitosan, agarose,
D-sorbite, mannitol or xylitol, proteoglycans, phosphatidyl choline, polylactide, polyglycolide, hydroxypropyl cellulose,
Wax, polyanhydride, polyamide, phosphorus based polymer, poly- (cyanoacrylate), polyurethane, polyorthoester, poly- dihydropyran, gathers polyester
One of acetal, Biodegradable polymeric, polypeptide, carbohydrate or their combination.
The active material of medical treatment or beautifying use can be drug or cosmetics molecule, including citric acid, protein, peptide, more
Sugar, antigen, immunogene, vaccine, antibody, enzyme, nucleic acid, aptamer, virus, bacterium, cell, hormone, antibiotic, anticancer drug,
The combination of genetically engineered drug, natural products drug, traditional Chinese medicine ingredients, nutritional ingredient, therapeutic agent, diagnosticum and mentioned reagent.
On the basis of embodiment 1, there is following alternative solution:
1, injected substrate 2 is separately formed by permeable 2-1 or water absorbent sheet 2-2.
2, dripping device has the weep pipe 4-1 of insertion push rod channel 3-1, and the outlet end of weep pipe 4-1, which is located at, closes on note
The top for penetrating substrate 2, the aqueous solution pumped out infuse the front to injected substrate 2 by weep pipe 4-1.
It is preferred that the water outlet of weep pipe 4-1 is blocked by flexible flaps, water outlet is made to be in normally off, flexible flaps
It is open in the pressure of the aqueous solution pumped out, flows out aqueous solution by water outlet.
Specifically, forming one of scheme of flexible flaps are as follows: the closing of the water outlet of weep pipe 4-1, sealing surface are logical
It crosses the cut-off rule intersected and is separated out more pieces of resilient limb.
3, dripping device includes water storage container 4-2, and the compressible deformation of water storage container 4-2, dripping device is by compressing water storage
The mode of container 4-2 pumps out the aqueous solution in water storage container 4-2.
4, dripping device includes water storage container 4-2 and thorn stick 4-4, and water storage container 4-2 has the sealer 4-5 by that can puncture
Closed upper and lower port, dripping device pierce through the sealer 4-5 of the upper and lower port water storage container 4-2 by thorn stick 4-4 from top to bottom
Mode flow out the aqueous solution in water storage container 4-2.
Embodiment 2, as illustrated in fig. 1 and 2:
A kind of dissolvable microneedle injection device, including propulsion device, injected substrate 2 and dripping device, injected substrate 2 are used for
Fixed injection micropin film 1, micropin film 1 include the micropin on microneedle substrate and microneedle substrate, and micropin film 1 is fixed on note
The back side of substrate 2 is penetrated, injected substrate 2 is the assembly of permeable 2-1 and water absorbent sheet 2-2, and water absorbent sheet 2-2 is located at permeable 2-1
The back side.Permeable 2-1 is carried out permeable by the permeable hole 2-1-1 on permeable 2-1, and water absorbent sheet 2-2 is by can water-absorption material texture
At.For pushing injected substrate 2 that micropin is pierced into position to be injected, dripping device is used to drip to injected substrate 2 propulsion device,
Through being absorbed after permeable 2-1 of injected substrate 2 by water absorbent sheet 2-2, the aqueous solution that water absorbent sheet 2-2 absorbs quickly dissolves aqueous solution
The microneedle substrate of micropin film 1 makes micropin stay in skin so that the microneedle substrate of the micropin for being pierced into skin and top be separated
It is interior, accurately discharge the drug of solvable dosage.
Permeable 2-1 is connected and fixed with 3 spiral of push rod.
Propulsion device includes that push rod 3, outer tube 5, power spring 6 and injection switching mechanism, push rod 3 are located in outer tube 5,
Push rod 3 is locked in initial position by injecting switching mechanism, injects switching mechanism by operation, unlocks push rod 3, push rod 3 exists
Decline under the action of power spring 6, pushes injected substrate 2 that micropin is pierced into position to be injected.
Injection switching mechanism includes the fixed switch deck 7 of the inner wall of opposite outer tube 5, has switch buckle 8 on push rod 3
And unlocking mechanism, when push rod 3 rises to initial position, the switch buckle 8 of push rod 3 blocks switch deck 7, and push rod 3 is locked
In having unlocking mechanism on initial position, outer tube 5, unlocking mechanism pull switch buckle 8 is detached from switch card seat 7, solves push rod 3
Lock.
Unlocking mechanism is the side press-key 9 of 5 side of outer tube, the setting position of side press-key 9 and quantity and switch buckle 8
Position it is consistent with quantity, by press side press-key 9, act on switch buckle 8 with making the inner end ecto-entad of side press-key 9
Outside, pull switch buckle 8 inwardly deformation until be detached from switch card seat 7.Specifically, side press-key 9 is the side of outer tube 5
The a part isolated on wall construction, only top is connect side press-key with the ontology of outer tube 5, keeps side press-key elastic multiple
Position.
Dripping device includes the piston 4-3 in water storage container 4-2 and water storage container 4-2, and piston 4-3 is specially ring-shaped rubber
Piston, water storage container 4-2 and piston 4-3 cover on push rod 3, and the inner cavity of water storage container 4-2 is pushed away by fluid channel and push rod 3
Bar channel 3-1 is communicated, and water storage container 4-2 and 3 secure fit of push rod, piston 4-3 are slidably matched with push rod 3, and piston 4-3 is towards note
Substrate 2 to be penetrated, there is piston push piece 12 protruding upward on the inner wall of outer tube 5, piston push piece 12 is located at the lower section of piston 4-3,
When declining under the action of push rod 3 is in power spring 6, piston push piece 12 plays barrier effect to piston 4-3, pushes piston 4-3 pump
Aqueous solution.
6 sets of power spring on push rod 3, switch buckle 8 is located at the position that the middle part of push rod 3 is close to, the two of power spring 6
It holds on piston push piece 12 and push rod 3, provides injection power for push rod 3.
Water storage container 4-2's has water inlet 13 and insurance sealing bar 14, and the end insertion push rod of insurance sealing bar 14 is logical
Road 3-1 seals off water storage container 4-2 and push rod channel 3-1, in injection mironeedle, extracts one section of insurance sealing bar outward
14, so that fluid channel and push rod channel 3-1 connection, it will be water-soluble during power spring 6 is propelled in state to be injected
It is hydraulic enter push rod channel 3-1, send to injected substrate 2.
Embodiment 3, as shown in Fig. 3,4,5,6,7,8 and 9:
A kind of dissolvable microneedle injection device, including propulsion device, injected substrate 2 and dripping device, injected substrate 2 are used for
Fixed injection micropin film 1, micropin film 1 include the micropin on microneedle substrate and microneedle substrate, and micropin film 1 is fixed on note
The back side of substrate 2 is penetrated, injected substrate 2 is separately formed by permeable 2-1, and permeable 2-1 passes through the permeable hole 2- on permeable 2-1
1-1 carries out permeable.The front of permeable 2-1 has the flow-guiding channel 2-1-2 communicated with permeable hole 2-1-1 with the back side, will transmit through
The aqueous solution of permeable 2-1 is uniformly guided to entire microneedle substrate.Propulsion device for push injected substrate 2 by micropin be pierced into
Injection site, for dripping device for dripping to injected substrate 2, aqueous solution dissolves the micropin base of micropin film 1 through injected substrate 2
Bottom.
Propulsion device includes that push rod 3, outer tube 5, power spring 6 and injection switching mechanism, injected substrate 2 are mounted on push rod
3 front end has in push rod 3 and leads to the positive push rod channel 3-1 of injected substrate 2.
Push rod 3 is located in outer tube 5, and push rod 3 is locked in initial position by injecting switching mechanism, is opened by operating injection
Shutting mechanism unlocks push rod 3, and push rod 3 declines under the action of power spring 6, pushes injected substrate 2 to be pierced into micropin to be injected
Position.
Injection switching mechanism includes the fixed switch deck 7 of the inner wall of opposite outer tube 5, has switch buckle 8 on push rod 3
And unlocking mechanism, when push rod 3 rises to initial position, the switch buckle 8 of push rod 3 blocks switch deck 7, and push rod 3 is locked
In having unlocking mechanism on initial position, outer tube 5, unlocking mechanism pull switch buckle 8 is detached from switch card seat 7, solves push rod 3
Lock.
Unlocking mechanism is the end key 10 of 5 rear end of outer tube, and top button is inserted into the rear end of outer tube 5, and top is pressed
The lower part of key has downwardly projecting lower edge, by pressing down on end key 10, makes the lower edge of end key 10 from top to bottom
The outside for acting on switch buckle 8, pull switch buckle 8 inwardly deformation until be detached from switch card seat 7.
For convenience of assembly, two sections are set by outer tube 5, two sections pass through the buckle connecting structure card of connecting pin
Button connection, naturally it is also possible to be connected by helicitic texture.
As shown in fig. 7, dripping device is flexible ripple dropper, the drop including water storage container 4-2 and the bottom water storage container 4-2
Water pipe 4-1, has the compressible deformation of water storage container 4-2 of flexible ripple struction, and weep pipe is inserted into the 4-1 of push rod channel 3-1, drop
The outlet end of water pipe 4-1 is located at the top for closing on injected substrate 2, and dripping device is pumped out by way of compressing water storage container 4-2
Aqueous solution in water storage container 4-2, the aqueous solution pumped out infuse the front to injected substrate 2 by weep pipe 4-1.
In order to which aqueous solution will not be easily flowed out when not squeezing water storage container 4-2, the water outlet of weep pipe 4-1 passes through bullet
Property limb block, so that water outlet be in normally off, flexible flaps are open in the pressure of the aqueous solution pumped out, make aqueous solution lead to
Cross water outlet outflow.Form the scheme of flexible flaps are as follows: the closing of the water outlet of weep pipe 4-1, sealing surface are divided by what is intersected
Secant is separated out more pieces of resilient limb.The cut-off rule of intersection is specially two separator bars of right-angled intersection.
The water storage container 4-2 of dripping device can also be made of elastic material or other elastic constructions.In order to allow aqueous solution
It will not be easily flowed out when not squeezing water storage container 4-2, weep pipe 4-1 can also use the lesser water outlet of diameter.
The lower section of end key 10 is arranged in water storage container 4-2, when pressing down on the unlock push rod 3 of end key 10, end
Portion's key 10 compresses water storage container 4-2 and pumps out aqueous solution.
The side of outer tube 5 also has movable push piece 11, and movable push piece 11 can be assemblied in up and downly on outer tube 5,
The inner end of movable push piece 11 acts on push rod 3, is moved up by operant activity push piece 11, makes the inner end band of movable push piece 11
Dynamic push rod 3 overcomes the spring force of power spring 6 to move down, until the switch buckle 8 of push rod 3 blocks switch deck 7.
Specifically, in the present embodiment, it there are two movable push pieces 11, is symmetrical arranged, outer tube 5 and pushes away on outer tube 5
All there is the sliding slot for installation activity push piece 11, the inner end of movable push piece 11 has buckle, is stuck in and pushes away on the side wall of bar 3
On the inner wall of the sliding slot of bar 3, the installation of movable push piece 11 is realized.It is moved up by operant activity push piece 11, movable push piece
The top of inner end acts on the upper end of the sliding slot of push rod 3, drives push rod 3 that the spring force of power spring 6 is overcome to move down.
For convenience of the reset of movable push piece 11, spring can be set between outer tube 5 and push rod 3, be pushed in movable push piece 11
After push rod 3 locks, by spring reset.The water storage container 4-2 of the present embodiment 3 has certain elasticity, can help end key 10
It resets, spring can also be redesigned certainly, pass through spring reset.
Microneedle injection process are as follows:
The end key 10 for pressing top unlocks push rod 3, and power spring 6 pushes push rod 3, by the micropin of micropin film 1
It is pierced into skin；End key 10 squeezes the water storage container 4-2 of flexible ripple dropper simultaneously, and aqueous solution washes weep pipe 4-1's open
Flexible flaps are flowed out from the water outlet of weep pipe 4-1, are sprayed at the top of injected substrate 2, injected substrate 2 rapidly permeable dissolution with
Its microneedle substrate being bonded after microneedle substrate dissolution, makes the micropin being pierced into skin and microneedle substrate separation, micropin is made to stay in skin
Dissolution release drug in skin.
Embodiment 4, as shown in Figure 10,11,12,13,14,15 and 16:
A kind of dissolvable microneedle injection device, the difference of the embodiment 4 and embodiment 3 are: dripping device includes water storage
Container 4-2 and thorn stick 4-4, water storage container 4-2 have the closed upper and lower port sealer 4-5 by that can puncture, and dripping device is logical
Cross the sealer 4-5 that thorn stick 4-4 pierces through the upper and lower port water storage container 4-2 from top to bottom mode make it is water-soluble in water storage container 4-2
Liquid stream goes out.
Thorn stick 4-4 is inserted into push rod channel 3-1, and the rear end of thorn stick 4-4 is connect with end key 10, and water storage container 4-2 is located at
The lower part of push rod channel 3-1, press down on end key 10 unlock push rod 3 when, end key 10 drive thorn stick 4-4 from up to
The lower sealer 4-5 for piercing through the upper and lower port water storage container 4-2, flows out the aqueous solution in water storage container 4-2.Sealer 4-5 specifically may be used
Using aluminium-foil paper.Sealer 4-5 is only shown in Figure 11, does not show sealer 4-5 in other accompanying drawings.
Injected substrate 2 includes permeable 2-1 and water absorbent sheet 2-2, the permeable hard plastic sheet for 1mm thickness, water absorbent sheet 2-2
It is made of polyvinyl acetate water filter membrane.
There is the permeable hole of a major diameter at the center of permeable 2-1, there is the bowl-shape support portion of protrusion on permeable hole,
Water storage container 4-2 is supported on the top of permeable mouth by bowl-shape support portion.The back side of water storage substrate has flow-guiding channel 2-1-2,
Aqueous solution is uniformly guided to the entire back side.
It is only enough in the microneedle substrate intensity of micropin film 1 because the permeable hole aperture of permeable 2-1 is relatively large
Under the premise of, it may be selected to omit water absorbent sheet 2-2.
For convenience of assembly, two sections are set by outer tube 5, two sections are connected by the helicitic texture on connecting pin
It connects.
Movable push piece 11 is cylindrical in shape, and is covered on push rod 2, and 5 side wall of outer tube has sliding slot, on the outer wall of movable push piece 11
Operating knob, operating knob are exposed by sliding slot, facilitate and operated, and have flange collar 15 on push rod 3, movable push piece 11 acts on convex
Drive push rod 3 that the spring force of power spring 6 is overcome to move down on circle 15.To help end key 10 to reset, in outer tube 5
Spring is designed, spring reset end key 10 is passed through.For convenience of thorn stick 4-4 reset, it is cased on thorn stick 4-4 and resets thorn stick 4-4
Spring.
Microneedle injection process are as follows:
The end key 10 for pressing top unlocks push rod 3, and power spring 6 pushes push rod, by the micropin of micropin film 1
It is pierced into skin；The thorn stick 4-4 of the drive of end key 10 simultaneously pierces through the sealer 4- of the upper and lower port water storage container 4-2 from top to bottom
5, the aqueous solution in water storage container 4-2 is flowed out, is sprayed at 2 top of injected substrate, water suction dissolution is viscous with it rapidly for injected substrate 2
The microneedle substrate connect after microneedle substrate dissolution, makes the micropin being pierced into skin and microneedle substrate separation, stays in micropin in skin
Dissolution release drug.
Claims (14)
1. a kind of dissolvable microneedle injection device, it is characterized in that: including propulsion device, injected substrate (2) and dripping device,
For injected substrate (2) for fixing injection micropin film (1), micropin film (1) includes on microneedle substrate and microneedle substrate
Micropin, micropin film (1) is fixed on the back side of injected substrate (2), injected substrate (2) porous or water suction,
For pushing injected substrate (2) that micropin is pierced into position to be injected, dripping device is used for injected substrate (2) propulsion device
It drips, aqueous solution absorbs to the microneedle substrate or injected substrate (2) of injected substrate (2) back side dissolution micropin film (1) water-soluble thoroughly
Liquid dissolves the microneedle substrate of micropin film (1).
2. dissolvable microneedle injection device according to claim 1, it is characterized in that: the injected substrate (2) is by permeable
Piece (2-1) or water absorbent sheet (2-2) are separately formed, and permeable (2-1) is carried out by the permeable hole (2-1-1) on permeable (2-1)
It is permeable, water absorbent sheet (2-2) by can water-absorption material texture at,
Alternatively, the injected substrate (2) is the assembly of permeable (2-1) and water absorbent sheet (2-2), water absorbent sheet (2-2) is located at
The back side of permeable (2-1).
3. dissolvable microneedle injection device according to claim 2, it is characterized in that: the back side of permeable (2-1),
Or front and the back side is with the flow-guiding channel (2-1-2) that communicates with permeable hole (2-1-1), will transmit through permeable (2-1) water-soluble
Liquid is uniformly guided to entire microneedle substrate.
4. dissolvable microneedle injection device according to claim 1, it is characterized in that: the propulsion device includes push rod
(3), injected substrate (2) is mounted on the front end of push rod (3), has in push rod (3) and leads to the positive push rod channel of injected substrate (2)
(3-1),
Dripping device is set up directly in push rod channel (3-1),
Alternatively, dripping device directly utilizes push rod channel (3-1) that the aqueous solution pumped out is infused to the front to injected substrate (2),
Alternatively, dripping device has the weep pipe (4-1) of insertion push rod channel (3-1), the outlet end of weep pipe (4-1), which is located at, to be faced
The top of nearly injected substrate (2), the aqueous solution pumped out infuse the front to injected substrate (2) by weep pipe (4-1).
5. dissolvable microneedle injection device according to claim 4, it is characterized in that: the water outlet of the weep pipe (4-1)
End is blocked by flexible flaps, so that water outlet is in normally off, flexible flaps are open in the pressure of the aqueous solution pumped out, make
Aqueous solution is flowed out by water outlet, alternatively, the water outlet of weep pipe (4-1) uses the lesser water outlet of diameter.
6. dissolvable microneedle injection device according to claim 4, it is characterized in that: the dripping device includes that water storage holds
Piston (4-3) in device (4-2) and water storage container (4-2), dripping device are pumped out in water storage container (4-2) by piston (4-3)
Aqueous solution；
Alternatively, the dripping device includes water storage container (4-2), water storage container (4-2) compressible deformation, dripping device passes through
The mode of compression water storage container (4-2) pumps out the aqueous solution in water storage container (4-2)；
Alternatively, the dripping device includes water storage container (4-2) and thorn stick (4-4), water storage container (4-2) has by that can pierce
The broken closed upper and lower port of sealer (4-5), dripping device pierce through water storage container (4-2) from top to bottom by thorn stick (4-4)
The mode of the sealer (4-5) of upper and lower port flows out the aqueous solution in water storage container (4-2).
7. dissolvable microneedle injection device according to claim 6, it is characterized in that: the propulsion device further includes housing
It manages (5), power spring (6) and injection switching mechanism, push rod (3) to be located in outer tube (5), push rod (3) passes through injection switching on and shutting down
Structure is locked in initial position, injects switching mechanism by operation, unlocks push rod (3), work of the push rod (3) in power spring (6)
With decline, push injected substrate (2) that micropin is pierced into position to be injected,
Dripping device by power spring (6) power completion drip movement or dripping device by operation inject switching on and shutting down
The operating force of structure completes movement of dripping.
8. dissolvable microneedle injection device according to claim 7, it is characterized in that: the injection switching mechanism includes phase
There is switch buckle (8) and unlocking mechanism on the fixed switch deck (7) of inner wall to outer tube (5), push rod (3),
When push rod (3) rises to initial position, the switch buckle (8) of push rod (3) blocks switch deck (7), and push rod (3) are locked
Due to having unlocking mechanism on initial position, outer tube (5), unlocking mechanism pull switch buckles (8) and is detached from switch card seat (7),
Unlock push rod (3).
9. dissolvable microneedle injection device according to claim 8, it is characterized in that: the unlocking mechanism is outer tube
(5) position and quantity one of the side press-key (9) of side, the setting position of side press-key (9) and quantity and switch buckle (8)
It causes, by pressing side press-key (9), acts on the outside of switch buckle (8) with making the inner end ecto-entad of side press-key (9),
Pull switch buckles (8) and is deformed inwardly until being detached from switch card seat (7).
10. dissolvable microneedle injection device according to claim 8, it is characterized in that: the unlocking mechanism is outer tube
(5) the end key (10) of rear end, top button are inserted into the rear end of outer tube (5), and the lower part of top button has downwardly convex
Lower edge out, by press down on end key (10), make the lower edge of end key (10) from top to bottom act on switch card
The outside of (8) is detained, pull switch buckles (8) and deformed inwardly until being detached from switch card seat (7).
11. dissolvable microneedle injection device according to claim 7, it is characterized in that: when dripping device includes water storage container
When piston (4-3) in (4-2) and water storage container (4-2),
Water storage container (4-2) and piston (4-3) cover on push rod (3), the inner cavity of water storage container (4-2) and the push rod of push rod (3)
(3-1) is communicated in channel, and water storage container (4-2) and push rod (3) secure fit, piston (4-3) are slidably matched with push rod (3), piston
(4-3) has piston push piece (12) protruding upward, piston push piece (12) towards injected substrate (2) on the inner wall of outer tube (5)
Positioned at the lower section of piston (4-3), when declining under the action of push rod (3) is in power spring (6), piston push piece (12) is to piston
(4-3) plays barrier effect, and piston (4-3) is pushed to pump out aqueous solution.
12. dissolvable microneedle injection device according to claim 10, it is characterized in that: when dripping device is compressible deformation
Water storage container (4-2) when, water storage container (4-2) setting is pressing down on top button solution in the lower section of end key (10)
When locking push rod (3), end key (10) compression water storage container (4-2) pumps out aqueous solution；
Alternatively, thorn stick (4-4) is inserted into push rod channel (3-1) when dripping device includes water storage container (4-2) and thorn stick (4-4),
The rear end of thorn stick (4-4) is connect with end key (10), and water storage container (4-2) is located at the lower part in push rod channel (3-1), downward
When pressing end key (10) unlock push rod (3), end key (10) drives thorn stick (4-4) to pierce through water storage container from top to bottom
The sealer (4-5) of the upper and lower port (4-2), flows out the aqueous solution in water storage container (4-2).
13. according to claim 7 or 8 or 9 or 10 or 11 or 12 or the dissolvable microneedle injection device, it is characterized in that: institute
The side for the outer tube (5) stated also has movable push piece (11), and movable push piece (11) can be assemblied in outer tube (5) up and downly
On, the inner end of movable push piece (11) acts on push rod (3), is moved up by operant activity push piece (11), makes movable push piece
(11) inner end drives push rod (3) that the spring force of power spring (6) is overcome to move down, until the switch buckle (8) of push rod (3)
Block switch deck (7).
14. dissolvable microneedle injection device according to claim 1, it is characterized in that: the aqueous solution is pure water solution,
Alternatively, aqueous solution is the pharmaceutical aqueous solution comprising drug ingedient or aqueous solution is the beauty aqueous solution comprising Cosmetic Ingredient.
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| CN201810933522.5A CN108939284B (en) | 2018-08-16 | 2018-08-16 | Dissolvable microneedle injection device |
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|---|---|---|---|
| CN201810933522.5A CN108939284B (en) | 2018-08-16 | 2018-08-16 | Dissolvable microneedle injection device |
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| CN108939284B (en) | 2023-08-08 |
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