CN108918467A - A kind of high-flux dry chemical detection devices - Google Patents
A kind of high-flux dry chemical detection devices Download PDFInfo
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- CN108918467A CN108918467A CN201810457098.1A CN201810457098A CN108918467A CN 108918467 A CN108918467 A CN 108918467A CN 201810457098 A CN201810457098 A CN 201810457098A CN 108918467 A CN108918467 A CN 108918467A
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- analoids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4735—Solid samples, e.g. paper, glass
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/04—Batch operation; multisample devices
- G01N2201/0438—Linear motion, sequential
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- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of high-flux dry chemical detection devices, have pedestal, sampling seat, transmission mechanism, temperature control raising module and optical detecting module；Pedestal is concave-shaped structure, center is equipped with the lower groove of front and back perforation, transmission mechanism is equipped in lower groove, for pushing analoids automatically, pedestal is equipped with rail cover, and the track of the rail cover is parallel corresponding with lower groove, and engaging has pushing block on track, for pushing analoids manually, sampling seat, temperature control raising module and optical detecting module is arranged in sequence in track one end；The detection device that this case is related to can be used for carrying out rapid quantitative detection, such as glucose, creatinine, glutamic-pyruvic transaminase, urotoxin etc. to the biochemical indicator in clinical blood sample, and the apparatus structure is simple, and detection efficiency is high, and stability is good, easy-to-use.
Description
Technical field
The present invention relates to chemical detection devices technical field, in particular to a kind of high-flux dry chemical detection devices.
Background technique
In clinical examination analysis, clinical analysis inspection is carried out using blood, urine or other body fluid, can quickly be obtained
Multiple Clinical laboratory tests as a result, being one of the most accurate, most straightforward approach that doctor is diagnosed.Carrying out clinical examination
In analysis, the wet chemistry analysis method being commonly used at present, the method that it has used referred to as solution chemistry.In general, using wet
The instrument of formula chemical analysis is based on the colorimetric method of Lambert-Beer's law.This detection method is needed through following step
Suddenly：Blood blood drawing, centrifugation, configuration reagent solution, Photoelectric Detection.The shortcomings that such detection method is：Reagent need to be with liquid mode
It saves, when detection need to be prepared work, need to be centrifuged whole blood to obtain serum, and entire detection needs the time longer.
Dry chemical is also known as solid state chemistry, using the solid-phase reagent technology of plural layers, as long as fluid sample is directly added
To the reagent carrier for having solidified into special construction, i.e., in the reagent of dry type, using the water in sample as solvent, carrier will be solidificated in
On reagent dissolution after, then chemically reacted with the ingredient to be measured in sample, so that analysis measurement is carried out, according to Kubelka-
Munk is theoretical, can calculate the concentration of determinand.
Dry chemistry analysis be for wet chemical analytical method, refer to by fluid test sample be applied directly to for
On the commercialized dried reagent item of the specific production of disparity items, specific chemistry is caused using the moisture of sample as solvent
Reaction, thus the method for carrying out chemical analysis.It, as measurement means, is mainly had using reflectance photometry method or differential electrode method
Following characteristics：Accuracy is high, speed is fast, and inspection result can be made generally in 3-4min；It is easy to operate, do not need daily school
Just；Any other reagent need not be storeed or prepare any solution；Sample need not pre-process, and multilayer film has the function of selective filter
Can, to reduce the influence of interfering substance in continuous mode；Sample dosage is few, and moisture when reaction is by the liquid component in sample
Supply improves measurement sensitivity.But multichannel high-flux dry chemical detection devices complex manufacturing technology in the prior art,
Higher cost is unfavorable for producing in batches, and therefore, it is necessary to a kind of new high-flux dry chemical detection devices to solve above-mentioned ask
Topic.
Summary of the invention
For the shortcomings of the prior art, the purpose of the present invention is to provide a kind of inspections of high-flux dry chemistry
Device is surveyed, can be used for carrying out rapid quantitative detection, such as glucose, creatinine, paddy third to the biochemical indicator in clinical blood sample
Transaminase, urotoxin, total bilirubin, triglycerides, lactic acid, ammonia, total cholesterol, uric acid, albumin, total protein etc., and should
Apparatus structure is simple, and detection efficiency is high, and stability is good, easy-to-use.
The present invention provides a kind of high-flux dry chemical detection devices, have pedestal, sampling seat, transmission mechanism, temperature control
Raising module and optical detecting module；
The pedestal is concave-shaped structure, and center is equipped with the lower groove of front and back perforation；Driver is equipped in the lower groove
Structure, for pushing analoids automatically；The pedestal is equipped with rail cover, and the track of the rail cover is parallel corresponding with lower groove；Institute
Stating engaging on track has pushing block, for pushing analoids manually；Sampling seat, temperature control raising module is arranged in sequence in described track one end
And optical detecting module；
Wherein, the transmission mechanism includes motor, gear, upper rack and lower rack gear；The tooth of the upper rack and lower rack gear
To on the contrary, respectively with gear coupling；The upper rack is connected with push rod, which rotates along positioning pin, for pushing analoids
Advance.
Preferably, the sampling seat is set up in above track, for fixing liquid-transfering gun so that sample liquid is added dropwise to analoids
Body.
Preferably, the temperature control raising module includes being incubated for storehouse and spring block；The incubation storehouse is set in lower groove,
For accommodating analoids；The spring block, which is located at, to be incubated for above storehouse, is incubated in storehouse and for being pushed downwardly into analoids to incubating
It educates storehouse and carries out insulation.
Preferably, the two sides for being incubated for storehouse are equipped with Peltier, to maintain to be incubated for storehouse temperature at 37 ± 1 DEG C；It is described
It is incubated for storehouse and at most accommodates 5 analoids simultaneously.
Preferably, the camera lens of the optical detecting module is opened in recessed trench bottom, and shading is equipped with above camera lens
Lid, for blocking veiling glare.
Preferably, the analoids side is equipped with groove, and the push rod which is connect with upper rack matches, makes to push away
Bar is stuck in groove and then analoids is pushed to advance.
Preferably, the pedestal lays dustbin in the outside for being equipped with optical detecting module side, for collecting inspection
The analoids surveyed.
Preferably, the operating process of the detection device is as follows：
1) analoids are placed in track, push pushing block, analoids are pushed into manually below sampling seat；
2) pipette holder is instilled into sample liquid on analoids by liquid-transfering gun on sampling seat；
3) start the motor in transmission mechanism, motor rotates forward, and upper rack advances, lower rack retreats, and upper rack and push rod will
Analoids are pushed into temperature control raising module below sampling seat；
4) after candidate agent piece is incubated for, motor reversal, upper rack is retreated, and lower rack gear advances, and lower rack gear pushes away analoids
To optical detecting module, optical detection is carried out；
5) after the detection of candidate agent piece, analoids are pushed into abandon position by motor reversal, lower rack gear；Motor rotates forward, on
Rack gear and lower rack gear return initial position, repeat same operation to next analoids.
The beneficial effects of the invention are as follows：Dry chemical detection device provided by the present invention, can be used for clinical blood sample
Biochemical indicator in this carries out rapid quantitative detection, and apparatus structure is simple, and detection efficiency is high, and stability is good, easy-to-use；Pass through
The mating reaction of device each section, most multipotency are incubated for 5 analoids simultaneously, make multiple analoids while being reacted, are not needed
Wait in line that sample liquid is added dropwise, realizes high-throughput detection, effectively improve working efficiency and convenience；In the present invention under pedestal
The end of groove one end is equipped with optical detecting module, is driven reverse the reagent that lower rack gear will be incubated for storehouse lowest part automatically by gear
Piece is pushed into the camera lens of alignment fluorescence detector from being incubated in storehouse, carry out optical detection；After sensing, analoids are direct by lower rack gear
Lower groove is released, pedestal is detached from and enters dustbin, realize pollution-free recycling.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of high throughput chemical detection device；
Fig. 2 is the cross-section structure main view of high throughput chemical detection device；
Wherein, 1- pedestal, 2- sampling seat, 3- transmission mechanism, 4- temperature control raising module, 5- optical detecting module, 6- rubbish
Rack gear under box, 11- lower groove, 12- rail cover, 13- track, 14- pushing block, 15- analoids, 31- gear, 32- upper rack, 33-,
34- push rod, 41- are incubated for storehouse, 42- spring block, 51- camera lens, 52- fluorescence detector.
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, to enable those skilled in the art referring to specification text
Word can be implemented accordingly.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more
The presence or addition of a other elements or combinations thereof.
The present invention provides a kind of high-flux dry chemical detection devices, as shown in Figs. 1-2, mainly by pedestal 1, sampling seat
2, transmission mechanism 3, temperature control raising module 4 and optical detecting module 5 form；Wherein, pedestal 1 is concave-shaped structure, and center is equipped with
The lower groove 11 of front and back perforation, is equipped with transmission mechanism 3 in lower groove 11, for pushing analoids 15 automatically, fastens on pedestal 1
There is rail cover 12, the track 13 of the rail cover 12 is parallel corresponding with lower groove 11, and length is shorter than lower groove 11, on track 13
Engaging has pushing block 14, for pushing analoids 15 manually；Temperature control is arranged in sequence than the part that track 13 is grown in lower groove 11 to incubate
Module 4 and optical detecting module 5 are educated, is provided with sampling seat 2 above 13 end of track, for fixing liquid-transfering gun with to reagent
Sample liquid is added dropwise in piece 15, and temperature control raising module 4 and optical detecting module are set in the lower groove 11 for being longer than track 13.
Further, transmission mechanism 3 includes motor, gear 31, upper rack 32 and lower rack gear 33, upper rack 32 and lower rack gear
On the contrary, coupling respectively with gear 31, while being connected with push rod 34 in upper rack 32, which turns 33 teeth directional along positioning pin
It is dynamic, advance for auxiliary pushing analoids 15；When motor rotates forward, upper rack 32 advances, and lower rack gear 33 retreats, and upper rack 32 will try
Agent piece 15 is shifted onto from load position and is incubated for position；When motor reversal, upper rack 32 is retreated, and lower rack gear 33 advances, and lower rack gear 32 will
Analoids 15 shift check bit onto from position is incubated for, then are pushed into abandon position from check bit；For upper rack 32 when advancing, push rod 34 can be with
The groove for withstanding analoids 15 pushes advance, and when upper rack 32 is retreated to rail cover 12, push rod 34 can go to lower section,
It avoids interference with；15 side of analoids is equipped with groove in this case, and the push rod 34 which is connect with upper rack 32 matches, makes to push away
Bar is stuck in groove and then analoids 15 is pushed steadily to advance.
Further, temperature control raising module 4 includes being incubated for storehouse 41 and spring block 42, is incubated for storehouse 41 and is set in lower groove,
For accommodating analoids, 5 analoids 15 are at most accommodated simultaneously, and spring block 42, which is located at, is incubated for 41 top of storehouse, can give analoids
15 apply a downward power, prevent from being jacked up by rack gear, and play heat-insulated effect, are equipped with pa in the two sides for being incubated for storehouse 41
You paste, to maintain to be incubated for storehouse temperature at 37 ± 1 DEG C.
Further, the camera lens 51 of optical detecting module 5 is opened in 11 bottom of lower groove, and is equipped with and hides above camera lens 51
Light lid avoids light disturbance for blocking veiling glare；Dustbin is laid in the outside that pedestal 1 is equipped with 5 side of optical detecting module
6, for collecting the analoids 15 detected.
The course of work of detection device is as follows in the present invention：Analoids are placed on track by user, and manual operation pushes away
Analoids are pushed into load position by block；By pipette holder on sampling seat, sample is instilled in analoids；Instrument brings into operation,
Motor rotates forward, and analoids are pushed into be incubated for position from load position by upper rack, and 5 analoids can be at most incubated for simultaneously by being incubated for storehouse；
It is incubated for after a certain period of time, motor reversal, the analoids for being incubated for storehouse bottom are pushed into detection position by lower rack gear, carry out optics inspection
It surveys；After the completion of detection, which is pushed into abandon position by motor reversal, lower rack gear, is fallen into dustbin；Motor rotates forward, tooth
Item retracts initial position；Same operating process is carried out to next analoids.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and legend shown and described herein.
Claims (8)
1. a kind of high-flux dry chemical detection devices, which is characterized in that have pedestal, sampling seat, transmission mechanism, temperature control to be incubated for
Module and optical detecting module；
The pedestal is concave-shaped structure, and center is equipped with the lower groove of front and back perforation；It is equipped with transmission mechanism in the lower groove, uses
In promotion analoids automatically；The pedestal is equipped with rail cover, and the track of the rail cover is parallel corresponding with lower groove；The track
Upper engaging has pushing block, for pushing analoids manually；Sampling seat, temperature control raising module and optics is arranged in sequence in described track one end
Detection module；
Wherein, the transmission mechanism includes motor, gear, upper rack and lower rack gear；The teeth directional phase of the upper rack and lower rack gear
Instead, respectively with gear coupling；The upper rack is connected with push rod, which rotates along positioning pin, for pushing analoids to advance.
2. detection device according to claim 1, which is characterized in that the sampling seat is set up in above track, for solid
Liquid-transfering gun is determined so that sample liquid is added dropwise to analoids.
3. detection device according to claim 1, which is characterized in that the temperature control raising module includes being incubated for storehouse and spring
Block；The incubation storehouse is set in lower groove, for accommodating analoids；The spring block, which is located at, to be incubated for above storehouse, for that will try
Agent piece, which is pushed downwardly into, to be incubated in storehouse and carries out insulation to storehouse is incubated for.
4. detection device according to claim 3, which is characterized in that the two sides for being incubated for storehouse are equipped with Peltier, with
Maintain to be incubated for storehouse temperature at 37 ± 1 DEG C；The incubation storehouse at most accommodates 5 analoids simultaneously.
5. detection device according to claim 1, which is characterized in that the camera lens of the optical detecting module is opened in recessed
Trench bottom, and shading cover is equipped with above camera lens, for blocking veiling glare.
6. detection device according to claim 1, which is characterized in that the analoids side be equipped with groove, the groove with
The push rod that upper rack is connected matches, and is stuck in push rod in groove and then analoids is pushed to advance.
7. detection device according to claim 1, which is characterized in that the pedestal is being equipped with optical detecting module side
Dustbin is laid in outside, for collecting the analoids detected.
8. detection device according to any one of claims 1-7, which is characterized in that the operation of the detection device
Journey is as follows：
1) analoids are placed in track, push pushing block, analoids are pushed into manually below sampling seat；
2) pipette holder is instilled into sample liquid on analoids by liquid-transfering gun on sampling seat；
3) start the motor in transmission mechanism, motor rotating forward, upper rack advance, lower rack retreats, upper rack and push rod for reagent
Piece is pushed into temperature control raising module below sampling seat；
4) after candidate agent piece is incubated for, motor reversal, upper rack is retreated, and lower rack gear advances, and analoids are pushed into light by lower rack gear
Detection module is learned, optical detection is carried out；
5) after the detection of candidate agent piece, analoids are pushed into abandon position by motor reversal, lower rack gear；Motor rotates forward, upper rack
Initial position is returned with lower rack gear, same operation is repeated to next analoids.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810457098.1A CN108918467B (en) | 2018-05-14 | 2018-05-14 | High-flux dry-type chemical detection device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810457098.1A CN108918467B (en) | 2018-05-14 | 2018-05-14 | High-flux dry-type chemical detection device |
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| CN108918467A true CN108918467A (en) | 2018-11-30 |
| CN108918467B CN108918467B (en) | 2021-05-18 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112705282A (en) * | 2019-10-25 | 2021-04-27 | 深圳华大智造科技有限公司 | Combined platform and detection device applying same |
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