CN108911967A - The preparation method of 2,5-dimethoxy-benzoyl chlorides - Google Patents
The preparation method of 2,5-dimethoxy-benzoyl chlorides Download PDFInfo
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- CN108911967A CN108911967A CN201810875257.XA CN201810875257A CN108911967A CN 108911967 A CN108911967 A CN 108911967A CN 201810875257 A CN201810875257 A CN 201810875257A CN 108911967 A CN108911967 A CN 108911967A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
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Abstract
Title of the invention is the preparation method of 2,5- dimethoxy-benzoyl chloride.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of preparation method of more advanced 2,5- dimethoxy-benzoyl chloride.The main points of the technical solution of the technical problems to be solved by the invention are the new preparation methods of one kind of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to 2, the preparation of 5- dimethoxy-benzoyl chloride
Method.
Background technique
2,5- dimethoxy-benzoyl chlorides are a kind of intermediate feeds of important synthesis medical product.
The preparation method yield of existing 2,5- dimethoxy-benzoyl chloride is not high, and synthesis technology is complicated, and yield is unstable,
Need to invent a kind of new preparation method, to overcome the shortcomings of prior art, to achieve the purpose that energy-saving and environmental protection, green.
Summary of the invention
The present invention use a kind of new technology, for existing 2,5- dimethoxy-benzoyl chloride preparation method yield not
Height, synthesis technology is complicated, and yield is unstable, the high disadvantage of the purchase cost of required raw material, by long-term research and development, invention
A kind of new preparation method has established good technical foundation to overcome the shortcomings of prior art for later industrial production.
The technical scheme is that:
1821 milligrams of 2,5- dimethoxybenzoic acids are added in the reactor, are added 40 milliliters of tetrahydrofuran, in stirring,
0.5 milliliter of n,N-Dimethylformamide is added in room temperature, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, so
After continue to be stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 2,5- diformazan
Oxygroup chlorobenzoyl chloride, yield 84.4%.
Specific embodiment
Embodiment 1:The preparation of 2,5- dimethoxy-benzoyl chlorides:
1821 milligrams of 2,5- dimethoxybenzoic acids are added in the reactor, are added 40 milliliters of tetrahydrofuran, in stirring,
0.5 milliliter of n,N-Dimethylformamide is added in room temperature, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, so
After continue to be stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 2,5- diformazan
Oxygroup chlorobenzoyl chloride, yield 84.4%.
Embodiment 2:The preparation of 2,5- dimethoxy-benzoyl chloride:
1821 milligrams of 2,5- dimethoxybenzoic acids are added in the reactor, are added 40 milliliters of tetrahydrofuran, in stirring,
0.5 milliliter of n,N-Dimethylformamide is added in room temperature, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, so
After continue to be stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 2,5- diformazan
Oxygroup chlorobenzoyl chloride, yield 85.6%.
The present invention can be summarized with others without prejudice to the concrete form of spirit or essential characteristics of the invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (2)
1. one kind 2, the preparation method of 5- dimethoxy formyl chloride, it is characterized in that:
1821 milligrams of 2,5- dimethoxybenzoic acids are added in the reactor, are added 40 milliliters of tetrahydrofuran, in stirring, in room temperature
0.5 milliliter of n,N-Dimethylformamide is added, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, then continues
It is stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 2,5- dimethoxy benzene
Formyl chloride, yield 84.4%.
2. according to the method described in claim 1, it is characterized in that:
It needs that compound N, dinethylformamide is added in reaction solution.
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CN201810875257.XA CN108911967A (en) | 2018-08-03 | 2018-08-03 | The preparation method of 2,5-dimethoxy-benzoyl chlorides |
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CN201810875257.XA CN108911967A (en) | 2018-08-03 | 2018-08-03 | The preparation method of 2,5-dimethoxy-benzoyl chlorides |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102939287A (en) * | 2010-06-10 | 2013-02-20 | 亚拉冈制药公司 | Estrogen receptor modulators and uses thereof |
CN103347859A (en) * | 2010-07-15 | 2013-10-09 | 台睿生物科技股份有限公司 | Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives |
WO2014013512A1 (en) * | 2012-07-19 | 2014-01-23 | Laurus Labs Private Limited | Improved process for preparation of 2,3-dihydroxy benzonitrile |
CN107406433A (en) * | 2014-12-18 | 2017-11-28 | 豪夫迈·罗氏有限公司 | Derivative for 2,3 diphenyl chromenes for the treatment of cancer |
-
2018
- 2018-08-03 CN CN201810875257.XA patent/CN108911967A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102939287A (en) * | 2010-06-10 | 2013-02-20 | 亚拉冈制药公司 | Estrogen receptor modulators and uses thereof |
CN103347859A (en) * | 2010-07-15 | 2013-10-09 | 台睿生物科技股份有限公司 | Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives |
WO2014013512A1 (en) * | 2012-07-19 | 2014-01-23 | Laurus Labs Private Limited | Improved process for preparation of 2,3-dihydroxy benzonitrile |
CN107406433A (en) * | 2014-12-18 | 2017-11-28 | 豪夫迈·罗氏有限公司 | Derivative for 2,3 diphenyl chromenes for the treatment of cancer |
Non-Patent Citations (4)
Title |
---|
LI, XIANG等: "Synthesis and Anti-tumor Evaluation of B-ring Modified Caged Xanthone Analogues of Gambogic Acid", 《CHIN. J. CHEM.》 * |
LLOYD G. CZAPLEWSKI等: "Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ", 《BIOORG. MED. CHEM. LETT.》 * |
张正等: "酰氯化合物的制备方法探讨", 《江苏化工》 * |
杨敏等: "Epidepr ide 的合成", 《药物化学》 * |
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