CN109020793A - The preparation method of 4- hydroxycinnamaldehyde - Google Patents
The preparation method of 4- hydroxycinnamaldehyde Download PDFInfo
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- CN109020793A CN109020793A CN201810977309.4A CN201810977309A CN109020793A CN 109020793 A CN109020793 A CN 109020793A CN 201810977309 A CN201810977309 A CN 201810977309A CN 109020793 A CN109020793 A CN 109020793A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Title of the invention is the preparation method of 4- hydroxycinnamaldehyde.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of preparation method of more advanced 4- hydroxycinnamaldehyde.The main points of the technical solution of the technical problems to be solved by the invention are the new preparation methods of one kind of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to a kind of preparation methods of 4- hydroxycinnamaldehyde.
Background technique
4- hydroxycinnamaldehyde is a kind of intermediate feed of important synthesis medical product.
The preparation method yield of existing 4- hydroxycinnamaldehyde is not high, and synthesis technology is complicated, and yield is unstable, needs to invent
A kind of new preparation method, to overcome the shortcomings of prior art.
Summary of the invention
The present invention uses a kind of new technology, not high for the preparation method yield of existing 4- hydroxycinnamaldehyde, synthesizes work
Skill is complicated, and yield is unstable, the high disadvantage of the purchase cost of required raw material, by long-term research and development, has invented a kind of new
Preparation method has established good technical foundation to overcome the shortcomings of prior art for later industrial production.
The technical scheme is that
1221 milligrams of 4- hydroxy benzaldehydes are added in the reactor, are added 5 milliliters and 10 milliliters of acetonitrile of pyridine, in stirring,
3 milliliters of acetaldehyde is added in room temperature, is then stirred at room temperature 30 minutes, adds 600 milligrams of potassium carbonate, then continues in room temperature
In be stirred to react 2 hours.After completion of the reaction, post-treated and purification process, obtains compound 4-hydroxy base cinnamic acid, and yield is
86.6%.
Specific embodiment
The preparation of embodiment 1:4- hydroxycinnamaldehyde:
1221 milligrams of 4- hydroxy benzaldehydes are added in the reactor, are added 5 milliliters and 10 milliliters of acetonitrile of pyridine, in stirring,
3 milliliters of acetaldehyde is added in room temperature, is then stirred at room temperature 30 minutes, adds 600 milligrams of potassium carbonate, then continues in room temperature
In be stirred to react 2 hours.After completion of the reaction, post-treated and purification process, obtains compound 4-hydroxy base cinnamic acid, and yield is
86.6%.
The preparation of embodiment 2:4- hydroxycinnamaldehyde:
1221 milligrams of 4- hydroxy benzaldehydes are added in the reactor, are added 5 milliliters and 10 milliliters of acetonitrile of pyridine, in stirring,
3 milliliters of acetaldehyde is added in room temperature, is then stirred at room temperature 30 minutes, adds 600 milligrams of potassium carbonate, then continues in room temperature
In be stirred to react 2 hours.After completion of the reaction, post-treated and purification process, obtains compound 4-hydroxy base cinnamic acid, and yield is
84.1%.
The present invention can be summarized with others without prejudice to the concrete form of spirit or essential characteristics of the invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (2)
- The preparation method of 1.4- hydroxycinnamaldehyde, it is characterized in that:1221 milligrams of 4- hydroxy benzaldehydes are added in the reactor, are added 5 milliliters and 10 milliliters of acetonitrile of pyridine, in stirring, room temperature The middle acetaldehyde for being added 3 milliliters, is then stirred at room temperature 30 minutes, adds 600 milligrams of potassium carbonate, then continue to stir at room temperature Mix reaction 2 hours.After completion of the reaction, post-treated and purification process, obtains compound 4-hydroxy base cinnamic acid, and yield is 86.6%.
- 2. according to the method described in claim 1, it is characterized in that:It needs that compound potassium carbonate is added in reaction solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810977309.4A CN109020793A (en) | 2018-08-27 | 2018-08-27 | The preparation method of 4- hydroxycinnamaldehyde |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810977309.4A CN109020793A (en) | 2018-08-27 | 2018-08-27 | The preparation method of 4- hydroxycinnamaldehyde |
Publications (1)
| Publication Number | Publication Date |
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| CN109020793A true CN109020793A (en) | 2018-12-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810977309.4A Pending CN109020793A (en) | 2018-08-27 | 2018-08-27 | The preparation method of 4- hydroxycinnamaldehyde |
Country Status (1)
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102992981A (en) * | 2012-12-24 | 2013-03-27 | 湖北远成药业有限公司 | Industrial preparation method of 3-methoxycinnamaldehyde |
| CN107556182A (en) * | 2017-10-17 | 2018-01-09 | 厦门大学 | The preparation method of the methoxycinnamic aldehyde of 3 hydroxyl 4 |
-
2018
- 2018-08-27 CN CN201810977309.4A patent/CN109020793A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102992981A (en) * | 2012-12-24 | 2013-03-27 | 湖北远成药业有限公司 | Industrial preparation method of 3-methoxycinnamaldehyde |
| CN107556182A (en) * | 2017-10-17 | 2018-01-09 | 厦门大学 | The preparation method of the methoxycinnamic aldehyde of 3 hydroxyl 4 |
Non-Patent Citations (3)
| Title |
|---|
| A.M. PATIL等: "Synthesis and Biological Evaluation of Novel 2,4-Thiazolidinedione Derivatives as Antibacterial Agent", 《ASIAN JOURNAL OF CHEMISTRY》 * |
| THIPPHAWAN CHUPRAJOD等: "Synthesis,cytotoxicity against human oral cancer KB cells and structure-activity relationship studies of trienone analogues of curcuminoids", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
| 陈露等: "固体超强碱Na2CO3/γ-Al2O3催化合成肉桂醛的研究", 《林产化学与工业》 * |
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Application publication date: 20181218 |