CN108904420A - Raw material of skin care articles composition with acne-removing and preparation method thereof, application - Google Patents
Raw material of skin care articles composition with acne-removing and preparation method thereof, application Download PDFInfo
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- CN108904420A CN108904420A CN201810685736.5A CN201810685736A CN108904420A CN 108904420 A CN108904420 A CN 108904420A CN 201810685736 A CN201810685736 A CN 201810685736A CN 108904420 A CN108904420 A CN 108904420A
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 29
- 206010000496 acne Diseases 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 239000002994 raw material Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 42
- 240000003377 Shepherdia canadensis Species 0.000 claims abstract description 31
- 235000018324 Shepherdia canadensis Nutrition 0.000 claims abstract description 31
- 238000004108 freeze drying Methods 0.000 claims abstract description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 240000003152 Rhus chinensis Species 0.000 claims abstract description 23
- 235000014220 Rhus chinensis Nutrition 0.000 claims abstract description 23
- 239000002904 solvent Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002537 cosmetic Substances 0.000 claims abstract description 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 6
- 102000004190 Enzymes Human genes 0.000 claims abstract description 6
- 108090000790 Enzymes Proteins 0.000 claims abstract description 6
- 239000004471 Glycine Substances 0.000 claims abstract description 6
- 229930195725 Mannitol Natural products 0.000 claims abstract description 6
- 230000034303 cell budding Effects 0.000 claims abstract description 6
- 150000004676 glycans Chemical class 0.000 claims abstract description 6
- 239000000594 mannitol Substances 0.000 claims abstract description 6
- 235000010355 mannitol Nutrition 0.000 claims abstract description 6
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 6
- 239000005017 polysaccharide Substances 0.000 claims abstract description 6
- 238000011049 filling Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 238000002137 ultrasound extraction Methods 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 238000005538 encapsulation Methods 0.000 claims description 5
- 235000019441 ethanol Nutrition 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 241001474374 Blennius Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 241000186427 Cutibacterium acnes Species 0.000 abstract description 13
- 229940055019 propionibacterium acne Drugs 0.000 abstract description 13
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 7
- 230000003255 anti-acne Effects 0.000 abstract description 5
- 230000018044 dehydration Effects 0.000 abstract description 5
- 238000006297 dehydration reaction Methods 0.000 abstract description 5
- 230000001815 facial effect Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 abstract description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 33
- 241000894006 Bacteria Species 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 229920000832 Cutin Polymers 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 208000001840 Dandruff Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000010100 anticoagulation Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000208223 Anacardiaceae Species 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 208000036828 Device occlusion Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 206010027146 Melanoderma Diseases 0.000 description 1
- 206010040954 Skin wrinkling Diseases 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000003399 chemotactic effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
Raw material of skin care articles composition that the present invention provides a kind of with acne-removing and preparation method thereof is applied, including freeze-dried powder and solvent, freeze-dried powder include：Glycerol, glycine, budding short stalk enzyme polysaccharide, trehalose, mannitol, nutgall extractive, soapberry extract, 10% sodium bicarbonate, surplus is water, solvent is water, the present invention inhibits the mass propagation of propionibacterium acnes using the good bacteriostasis of nutgall extractive, be aided with the removing facial oil of soapberry extract, antibacterial, anti-inflammatory effect come the effect of reaching anti-acne；And freeze-dried powder is produced using freeze drying process, it can more complete to retain soapberry and gallic activity, thoroughly, the holding time is long for dehydration, rehydration is fast, easy to use, is gentle, and easily absorbs, it is non-stimulated, meet requirement of the people to cosmetics safety validity, has a extensive future.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to a kind of raw material of skin care articles composition with acne-removing and
Preparation method, application.
Background technique
The generation of acne mainly with hypersteatosis, pilosebaceous duct blocking, bacterium infection and inflammatory reaction etc.
Factor is closely related.The level of androgen especially testosterone in descendant's body that adolesces increases rapidly, promotes sebaceous glands development
And generate a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, and dyssebacia forms cutin
Bolt, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes mass propagation in hair follicle, the lipase that propionibacterium acnes generate
It decomposes sebum and generates free fatty acid, while chemotactic inflammatory cell and medium, finally induce and aggravate inflammatory reaction.
Chinese medicine Chinese gall is the drying insect gall on Anacardiaceae plant Chinese sumac, potanin sumac or redpunjab sumac root leaf, mainly by five
Gall nut aphid is parasitic and is formed.Its is cold in nature, sour, puckery, other than with astringing lung-QI fall fire, hygroscopic sore and other effects, also has good
Bacteriostasis.
Soapberry extract foaming abundancy, feel is fine and smooth, and strong detergency can improve skin quality, make its exquisite luster, richness
It is flexible.The effects of there are also antibacterial, anti-inflammatory, oxidation and removing free radicals, anticoagulations simultaneously.Tartaric acid in soapberry helps skin
Removal is deposited in the aging cutin of outer layer, accelerates skin renewal, help improve skin whelk, blackspot, wrinkle, dry skin,
Coarse equal skin problem.The effect of antibacterial, anti-dandruff, anticreep, whitening despeckle, skin care：" soapberry can pre- anti-dandruff ", this
It is at all exactly common sense for the Chinese of usual traditional, natural washing product.It is washed using soapberry soap cream
Head, it is also effective according to popular legend for prevention hair loss.Tea polyphenols in soapberry are water-soluble substances, and face can be removed by being washed one's face with it
Grease, the convergence pore in portion, can sterilize, sterilize, resisting age of skin, can be reduced damage of the daylight middle-ultraviolet lamp radiation to skin
Deng.Ferulic acid in soapberry is the generally acknowledged cosmetic factor of scientific circles, can improve skin quality, make its exquisiteness, gloss, rich in bullet
Property.Simultaneously there are also antibacterial, anti-inflammatory, it is anti-oxidant, remove free radical, anticoagulation the effects of.Tartaric acid in soapberry can help skin
Removal is deposited in the aging cutin of outer layer.
Summary of the invention
Raw material of skin care articles composition that the purpose of the present invention is to provide a kind of with acne-removing and preparation method thereof is answered
With.
The technical solution adopted by the present invention is that：
A kind of raw material of skin care articles composition with acne-removing, it is characterised in that：Including freeze-dried powder and solvent, the freeze-dried powder
Component including following mass parts：0.1 ~ 0.3 part of glycerol, 0.2 ~ 0.5 part of glycine, 0.3 ~ 0.5 part of short stalk enzyme polysaccharide of budding, sea
0.6 ~ 1.0 part of algae sugar, 5 ~ 8 parts of mannitol, 2 ~ 5 parts of nutgall extractive, 5 ~ 10 parts of soapberry extract, 10% sodium bicarbonate 1
~ 2 parts, surplus is water, and the solvent is water.
A kind of preparation method of the raw material of skin care articles composition with acne-removing includes the following steps：
Step 1：Chinese gall be crushed into 20 meshes, obtained gallnut extract is minced, to gallnut extract mince in by 1：5~10
Ratio uses Vltrasonic device ultrasonic extraction after deionized water is added, and slow filter paper filtering obtains nutgall extractive；
Step 2：Soapberry raw material is crushed, spaonin powder is obtained and minces, to spaonin powder mince in by 1：10 ~ 20 ratios are added
70% ethyl alcohol, 70 DEG C of 2 ~ 5h of condensing reflux, slow filter paper filtering, 70 DEG C of filtrate are concentrated into the 1/5 ~ 1/3 of original weight, obtain no trouble
Seed extract；
Step 3：It is filling, after the freeze-dried powder is configured to liquid in formula composition ratio, by the requirement it is filling after, into
Row freeze-drying；
Step 4：Freeze-drying, pre-freeze is no less than 3 hours at -45 DEG C, is evacuated at -40 DEG C no more than 1Pa, then
It controls temperature to be improved by -40 DEG C to 30 DEG C, control temperature rate of change is 5 DEG C, and the freeze-drying time of every temperature gradient is no less than
The total time of 30min, freeze-drying are no less than 26h；
Step 5：Roll lid encapsulation, after freeze-drying, sealed package under vacuum.
The supersonic frequency 30kHz of the ultrasonic extraction, temperature are 40 DEG C, ultrasonic time 20min.
In the freezing dry process, -35 DEG C of 120 ~ 180min of operation, -25 DEG C of 240 ~ 300min of operation, -15 DEG C are transported
Row 180 ~ 240min, 0 DEG C, 25 DEG C and 30 DEG C operation 120 ~ 180min, 30 DEG C of 30 ~ 90min of operation.
In the freezing dry process, -35 DEG C of operations 150min, -25 DEG C of operations 260min, -15 DEG C of operation 210min,
0 DEG C, 25 DEG C and 30 DEG C operation 150min, 30 DEG C of operation 60min.
A kind of application of the raw material of skin care articles composition with acne-removing in cosmetics is：It is added in freeze-dried powder molten
Mixed liquor is applied on skin by matchmaker after mixing evenly, and the dosage of the solvent is 1 ~ 5ml, the dosage of the freeze-dried powder
For 50 ~ 200mg.
Advantages of the present invention：Inhibit a large amount of numerous of propionibacterium acnes using the good bacteriostasis of nutgall extractive
Grow, be aided with the removing facial oil of soapberry extract, antibacterial, anti-inflammatory effect come the effect of reaching anti-acne；And using freezing
Drying process produces freeze-dried powder, can more complete to retain soapberry and gallic activity, and thoroughly, the holding time is long for dehydration,
Rehydration is fast, easy to use, is gentle, and easily absorbs, non-stimulated, meets requirement of the people to cosmetics safety validity, applies
It has a extensive future.
Detailed description of the invention
The present invention is described in further detail with reference to the accompanying drawings and detailed description.
Fig. 1 is that the present invention has the comparison diagram for inhibiting propionibacterium acnes effect.
Specific embodiment
In order to deepen the understanding of the present invention, the present invention will be described in further detail with reference to the examples below, the embodiment
For explaining only the invention, it does not restrict the protection scope of the present invention.
Embodiment 1：
A kind of raw material of skin care articles composition with acne-removing, including freeze-dried powder and solvent, freeze-dried powder include following mass parts
Component：0.1 part of glycerol, 0.3 part of glycine, budding 0.4 part of short stalk enzyme polysaccharide, 0.8 part of trehalose, 7 parts, five times of mannitol
3 parts of seed extract, 7 parts of soapberry extract, 1.15 parts of 10% sodium bicarbonate, surplus are water, and solvent is water.
A kind of preparation method of the raw material of skin care articles composition with acne-removing includes the following steps：
Step 1：Chinese gall be crushed into 20 meshes, obtained gallnut extract is minced, to gallnut extract mince in by 1：7 ratios
Vltrasonic device ultrasonic extraction is used after deionized water is added, slow filter paper filtering obtains nutgall extractive；
Step 2：Soapberry raw material is crushed, spaonin powder is obtained and minces, to spaonin powder mince in by 1：70% second is added in 15 ratios
Alcohol, 70 DEG C of condensing reflux 3.5h, slow filter paper filtering, 70 DEG C of filtrate are concentrated into the 1/4 of original weight, obtain soapberry extract；
Step 3：It is filling, after freeze-dried powder is configured to liquid in formula composition ratio, after filling as required, it is freeze-dried；
Step 4：Freeze-drying, 3.5 hours of pre-freeze, vacuumize 1Pa at -40 DEG C at -45 DEG C, then control temperature by -
40 DEG C are improved to 30 DEG C, and control temperature rate of change is 5 DEG C, and the freeze-drying time of every temperature gradient is no less than 30min, -35 DEG C of fortune
Row 150min, -25 DEG C of operation 260min, -15 DEG C of operation 210min, 0 DEG C, 25 DEG C and 30 DEG C operation 150min, 30 DEG C run
The total time of 60min, freeze-drying are no less than 26h；
Step 5：Roll lid encapsulation, after freeze-drying, sealed package under vacuum.
The supersonic frequency 30kHz of ultrasonic extraction, temperature are 40 DEG C, ultrasonic time 20min.
A kind of application of the raw material of skin care articles composition with acne-removing in cosmetics is：It is added in freeze-dried powder molten
Mixed liquor is applied on skin by matchmaker after mixing evenly, and the dosage of solvent is 5ml, and the dosage of freeze-dried powder is 200mg.
The present invention inhibits the mass propagation of propionibacterium acnes using the good bacteriostasis of nutgall extractive, is aided with
The removing facial oil of soapberry extract, antibacterial, anti-inflammatory effect come the effect of reaching anti-acne；And use freeze drying process
Freeze-dried powder is produced, can more complete to retain soapberry and gallic activity, thoroughly, the holding time is long, and rehydration is fast, makes for dehydration
It with conveniently, is gentle, easily absorbs, it is non-stimulated, meet requirement of the people to cosmetics safety validity, has a extensive future.
Embodiment 2：
A kind of raw material of skin care articles composition with acne-removing, including freeze-dried powder and solvent, freeze-dried powder include following mass parts
Component：0.2 part of glycerol, 0.4 part of glycine, budding 0.3 part of short stalk enzyme polysaccharide, 0.6 part of trehalose, 8 parts, five times of mannitol
2 parts of seed extract, 8 parts of soapberry extract, 1.5 parts of 10% sodium bicarbonate, surplus are water, and solvent is water.
A kind of preparation method of the raw material of skin care articles composition with acne-removing includes the following steps：
Step 1：Chinese gall be crushed into 20 meshes, obtained gallnut extract is minced, to gallnut extract mince in by 1：5 ratios
Vltrasonic device ultrasonic extraction is used after deionized water is added, slow filter paper filtering obtains nutgall extractive；
Step 2：Soapberry raw material is crushed, spaonin powder is obtained and minces, to spaonin powder mince in by 1：70% second is added in 10 ratios
Alcohol, 70 DEG C of condensing reflux 2h, slow filter paper filtering, 70 DEG C of filtrate are concentrated into the 1/5 of original weight, obtain soapberry extract；
Step 3：It is filling, after freeze-dried powder is configured to liquid in formula composition ratio, after filling as required, it is freeze-dried；
Step 4：Freeze-drying, 3.5 hours of pre-freeze, 1Pa is evacuated at -40 DEG C, then controls temperature at -45 DEG C
It being improved by -40 DEG C to 30 DEG C, control temperature rate of change is 5 DEG C, and the freeze-drying time of every temperature gradient is no less than 30min, -35 DEG C
120min is run, -25 DEG C of operation 240min, -15 DEG C of operation 180min, 0 DEG C, 25 DEG C and 30 DEG C operation 120min, 30 DEG C run
The total time of 30min, freeze-drying are no less than 26h；
Step 5：Roll lid encapsulation, after freeze-drying, sealed package under vacuum.
The supersonic frequency 30kHz of ultrasonic extraction, temperature are 40 DEG C, ultrasonic time 20min.
A kind of application of the raw material of skin care articles composition with acne-removing in cosmetics is：It is added in freeze-dried powder molten
Mixed liquor is applied on skin by matchmaker after mixing evenly, and the dosage of the solvent is 2ml, and the dosage of the freeze-dried powder is
50mg。
The present invention inhibits the mass propagation of propionibacterium acnes using the good bacteriostasis of nutgall extractive, is aided with
The removing facial oil of soapberry extract, antibacterial, anti-inflammatory effect come the effect of reaching anti-acne；And use freeze drying process
Freeze-dried powder is produced, can more complete to retain soapberry and gallic activity, thoroughly, the holding time is long, and rehydration is fast, makes for dehydration
It with conveniently, is gentle, easily absorbs, it is non-stimulated, meet requirement of the people to cosmetics safety validity, has a extensive future.
Embodiment 3：
A kind of raw material of skin care articles composition with acne-removing, including freeze-dried powder and solvent, the freeze-dried powder include following matter
Measure the component of part：0.3 part of glycerol, 0.4 part of glycine, budding 0.4 part of short stalk enzyme polysaccharide, 0.6 part of trehalose, 7 parts of mannitol,
2 parts of nutgall extractive, 5 parts of soapberry extract, 1.5 parts of 10% sodium bicarbonate, surplus are water, and solvent is water.
A kind of preparation method of the raw material of skin care articles composition with acne-removing includes the following steps：
Step 1：Chinese gall be crushed into 20 meshes, obtained gallnut extract is minced, to gallnut extract mince in by 1：10 ratios
Example uses Vltrasonic device ultrasonic extraction after deionized water is added, and slow filter paper filtering obtains nutgall extractive；
Step 2：Soapberry raw material is crushed, spaonin powder is obtained and minces, to spaonin powder mince in by 1：70% second is added in 20 ratios
Alcohol, 70 DEG C of condensing reflux 5h, slow filter paper filtering, 70 DEG C of filtrate are concentrated into the 1/3 of original weight, obtain soapberry extract；
Step 3：It is filling, after the freeze-dried powder is configured to liquid in formula composition ratio, by the requirement it is filling after, into
Row freeze-drying；
Step 4：Freeze-drying, 3.5 hours of pre-freeze, 1Pa is evacuated at -40 DEG C, then controls temperature at -45 DEG C
It being improved by -40 DEG C to 30 DEG C, control temperature rate of change is 5 DEG C, and the freeze-drying time of every temperature gradient is no less than 30min, -35 DEG C
180min is run, -25 DEG C of operation 300min, -15 DEG C of operation 240min, 0 DEG C, 25 DEG C and 30 DEG C operation 180min, 30 DEG C run
90min.The total time of freeze-drying is no less than 26h；
Step 5：Roll lid encapsulation, after freeze-drying, sealed package under vacuum.
The supersonic frequency 30kHz of ultrasonic extraction, temperature are 40 DEG C, ultrasonic time 20min.
A kind of application of the raw material of skin care articles composition with acne-removing in cosmetics is：It is added in freeze-dried powder molten
Mixed liquor is applied on skin by matchmaker after mixing evenly, and the dosage of the solvent is 3ml, and the dosage of the freeze-dried powder is
200mg。
The present invention inhibits the mass propagation of propionibacterium acnes using the good bacteriostasis of nutgall extractive, is aided with
The removing facial oil of soapberry extract, antibacterial, anti-inflammatory effect come the effect of reaching anti-acne；And use freeze drying process
Freeze-dried powder is produced, can more complete to retain soapberry and gallic activity, thoroughly, the holding time is long, and rehydration is fast, makes for dehydration
It with conveniently, is gentle, easily absorbs, it is non-stimulated, meet requirement of the people to cosmetics safety validity, has a extensive future.
About experiment 1 of the invention：
There are this kind the skin care item of acne-removing to inhibit propionibacterium acnes test
Experimental material：0.85%NaCl, 30% glycerol, this kind have the skin care item of acne-removing
Experiment purpose：Testing this kind has the function of whether the skin care item of acne-removing have inhibition propionibacterium acnes
Experimental procedure：
（1）With sample concentration
Using 0.85%NaCl as negative control, 30% glycerol is as positive control, every group of 5 EP pipe, is separately added into bacterium solution, and 27 DEG C
Place a night.It will be handled to tomorrow.
（2）Confirm diluted concentration：
0.85%NaCl group is diluted into 10^1,10^2,10^3,10^4, takes 0.01ml point on corresponding culture medium, 27 DEG C of trainings
It supports one day, number clump count, using extension rate of the clump count between 10-50 as experiment extension rate.
Propionibacterium acnes extension rate 10^4.
（3）The sample bacterium solution for handling 1d is diluted to experiment extension rate（Stoste, 10^1,10^2 ~ 10^n）, respectively take
For 0.01mL point on corresponding culture medium, 1-3d is cultivated in 27 DEG C of back-offs, observes bacterium colony growing state, number clump count；Respectively take
For 0.05mL point on corresponding culture medium, 1-3d is cultivated in 27 DEG C of back-offs, observes bacterium colony growing state, and number clump count calculates bacterium
Inhibiting rate（%）.
Inhibiting rate（%）Formula=（1- each group clump count cfu/ml/Saline group clump count cfu/ml）*100.
（4）If inhibiting rate（%）It is below standard, 3d, 7d etc. are continued with, step is repeated（3）
Experimental result：
1d
5d
As a result：This kind has with the skin care item of acne-removing inhibits propionibacterium acnes effect.
Conclusion：This kind has the skin care item of acne-removing can be by inhibiting to reach effective inhibition by propionibacterium acnes
The effect of whelk.
Claims (6)
1. the raw material of skin care articles composition with acne-removing, it is characterised in that：Including freeze-dried powder and solvent, the freeze-dried powder packet
Include the component of following mass parts：0.1 ~ 0.3 part of glycerol, 0.2 ~ 0.5 part of glycine, budding 0.3 ~ 0.5 part of short stalk enzyme polysaccharide, seaweed
Sugared 0.6 ~ 1.0 part, 5 ~ 8 parts of mannitol, 2 ~ 5 parts of nutgall extractive, 5 ~ 10 parts of soapberry extract, 10% sodium bicarbonate 1 ~ 2
Part, surplus is water, and the solvent is water.
2. the preparation method of the raw material of skin care articles composition according to claim 1 with acne-removing includes following step
Suddenly：
Step 1：Chinese gall be crushed into 20 meshes, obtained gallnut extract is minced, to gallnut extract mince in by 1：5~10
Ratio uses Vltrasonic device ultrasonic extraction after deionized water is added, and slow filter paper filtering obtains nutgall extractive；
Step 2：Soapberry raw material is crushed, spaonin powder is obtained and minces, to spaonin powder mince in by 1：10 ~ 20 ratios are added
70% ethyl alcohol, 70 DEG C of 2 ~ 5h of condensing reflux, slow filter paper filtering, 70 DEG C of filtrate are concentrated into the 1/5 ~ 1/3 of original weight, obtain no trouble
Seed extract；
Step 3：It is filling, after the freeze-dried powder is configured to liquid in formula composition ratio, by the requirement it is filling after, into
Row freeze-drying；
Step 4：Freeze-drying, pre-freeze is no less than 3 hours at -45 DEG C, is evacuated at -40 DEG C no more than 1Pa, then
It controls temperature to be improved by -40 DEG C to 30 DEG C, control temperature rate of change is 5 DEG C, and the freeze-drying time of every temperature gradient is no less than
The total time of 30min, freeze-drying are no less than 26h；
Step 5：Roll lid encapsulation, after freeze-drying, sealed package under vacuum.
3. the preparation method of the raw material of skin care articles composition according to claim 2 with acne-removing, it is characterised in that：
The supersonic frequency 30kHz of the ultrasonic extraction, temperature are 40 DEG C, ultrasonic time 20min.
4. the preparation method of the raw material of skin care articles composition according to claim 2 with acne-removing, it is characterised in that：
In the freezing dry process, -35 DEG C of operation 120 ~ 180min, -25 DEG C of 240 ~ 300min of operation, -15 DEG C of operations 180 ~
240min, 0 DEG C, 25 DEG C and 30 DEG C operation 120 ~ 180min, 30 DEG C of 30 ~ 90min of operation.
5. the preparation method of the raw material of skin care articles composition according to claim 2 with acne-removing, it is characterised in that：
In the freezing dry process, -35 DEG C of operation 150min, -25 DEG C of operation 260min, -15 DEG C of operation 210min, 0 DEG C, 25 DEG C
With 30 DEG C of operations 150min, 30 DEG C of operation 60min.
6. the raw material of skin care articles composition according to claim 1 with acne-removing, it is characterised in that：In cosmetics
Application be：Solvent is added in freeze-dried powder, after mixing evenly, mixed liquor is applied on skin, the dosage of the solvent
For 1 ~ 5ml, the dosage of the freeze-dried powder is 50 ~ 200mg.
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| CN110438192A (en) * | 2019-09-19 | 2019-11-12 | 大连工业大学 | A kind of preparation method and applications of sugar-free small molecule Gly-His-Lys |
| CN110484584A (en) * | 2019-09-19 | 2019-11-22 | 大连工业大学 | It is a kind of with the preparation method and applications for delaying bone-loss active peptides |
| CN110541020A (en) * | 2019-09-19 | 2019-12-06 | 大连工业大学 | preparation method of oyster polypeptide with osteogenic activity |
| CN110541019A (en) * | 2019-09-19 | 2019-12-06 | 大连工业大学 | preparation method of bone-promoting small-molecule peptide |
| CN110551789A (en) * | 2019-09-19 | 2019-12-10 | 大连工业大学 | Preparation method of mussel peptide freeze-dried powder with osteogenic activity |
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Cited By (7)
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| CN109381357A (en) * | 2018-12-13 | 2019-02-26 | 广州宝莱生物科技有限公司 | A kind of anti-acne moisturizing leech freeze-dried powder |
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| CN110438192A (en) * | 2019-09-19 | 2019-11-12 | 大连工业大学 | A kind of preparation method and applications of sugar-free small molecule Gly-His-Lys |
| CN110484584A (en) * | 2019-09-19 | 2019-11-22 | 大连工业大学 | It is a kind of with the preparation method and applications for delaying bone-loss active peptides |
| CN110541020A (en) * | 2019-09-19 | 2019-12-06 | 大连工业大学 | preparation method of oyster polypeptide with osteogenic activity |
| CN110541019A (en) * | 2019-09-19 | 2019-12-06 | 大连工业大学 | preparation method of bone-promoting small-molecule peptide |
| CN110551789A (en) * | 2019-09-19 | 2019-12-10 | 大连工业大学 | Preparation method of mussel peptide freeze-dried powder with osteogenic activity |
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Address after: 226100 1 Tianmu Lake Road, Linjiang new area, Haimen, Nantong, Jiangsu Applicant after: HYUNDAI BIOLAND(Jiangsu) Co.,Ltd. Applicant after: GUANGZHOU BAOLAI BIOTECHNOLOGY Co.,Ltd. Address before: 226100 1 Tianmu Lake Road, Linjiang new area, Haimen, Nantong, Jiangsu Applicant before: SK BIOLAND BIOTECHNOLOGY (HAIMEN) Co.,Ltd. Applicant before: GUANGZHOU BAOLAI BIOTECHNOLOGY Co.,Ltd. |
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