CN108852963A - A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture - Google Patents
A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture Download PDFInfo
- Publication number
- CN108852963A CN108852963A CN201810805019.1A CN201810805019A CN108852963A CN 108852963 A CN108852963 A CN 108852963A CN 201810805019 A CN201810805019 A CN 201810805019A CN 108852963 A CN108852963 A CN 108852963A
- Authority
- CN
- China
- Prior art keywords
- extract
- microneedle patch
- preserving moisture
- replenishing water
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The embodiment of the present disclosure discloses a kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture, it is related to skin care field, the microneedle patch includes body supports ingredient and functional component, body supports ingredient is made of the degradation material with biocompatibility, and functional component percentage composition by weight is composed of the following components：Jojoba extract 10%~30%, Herba Lysimachiae foenumgraeci extract 3%~5%, aloe extract 15%~25%, unusual berry extract 5%~10%, Angelica Dahurica extract 2%~5%, Semen phaseoli radiati extract 5%~10%, urea 10%~15%, ceramide 5%~10%, auxiliary additive 10%~25%.The microneedle patch of the disclosure can effectively pierce through skin, duct be formed in skin surface, as the degradation material of body supports ingredient dissolves in skin rapidly, functional component may be absorbed by skin corium rapidly, it keeps the skin wet and nutriment, fundamentally improves skin exsiccosis, and highly-safe.
Description
Technical field
This disclosure relates to skin care field, and in particular to a kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture.
Background technique
With the progress of society and the development of science and technology, skin care has become that people increasingly pay attention in the modern times
It asks, for the women much to like to be beautiful, skin condition just represents the age.In extraneous factor such as ultraviolet light irradiation, sky
Gas pollution, seasonal law etc. and internal factor such as age increase, metabolism slows down, and can all cause skin immanent structure impaired,
The decline of moisture ability is kept, the skin problems such as dry, dull, coarse, aging are generated.The main dosage form of contemporary skin care product has water
Agent, lotion, cream, spraying, gel and facial mask, but due to the obstruction of keratoderma, be only coated on skin surface it is effective at
Divide and be often difficult to enter corium, therefore the effect of replenishing water and preserving moisture is very little, skin only can be after using skin care item in short-term
It is interior show smooth water is tender, and can not really improve the drying exsiccosis of skin, can not also fully meet current consumption
The demand of person.
Summary of the invention
In view of the deficiencies in the prior art, the disclosure is designed to provide a kind of microneedle patch for replenishing water and preserving moisture
Piece and preparation method thereof has significant replenishing water and preserving moisture effect, and toxic side effect is small.
To achieve the above objectives, the disclosure adopts the technical scheme that：A kind of microneedle patch for replenishing water and preserving moisture, including
Body supports ingredient and effect ingredient being dispersed in body supports ingredient, the body supports ingredient is by with biocompatibility
Degradation material be made, functional component percentage composition by weight is composed of the following components：Jojoba extract 10%~
30%, Herba Lysimachiae foenumgraeci extract 3%~5%, aloe extract 15%~25%, unusual berry extract 5%~10%, the root of Dahurain angelica extract
Object 2%~5%, Semen phaseoli radiati extract 5%~10%, urea 10%~15%, ceramide 5%~10%, auxiliary additive
10%~25%.
Based on the above technical solution, the auxiliary additive be glycerol, vitamin E, ascorbic acid, allantoin,
Any one or a few mixture in kojic acid, salicylic acid, squalene, polysorbas20, polysorbate40, polysorbate60 and Tween 80.
Based on the above technical solution, the degradation material is that hyaluronic acid, maltose, chitosan, sulfuric acid are soft
Ossein sodium, sodium alginate, amylopectin, polylactic acid, polyglycolic acid, polyethylene glycol oxide, polyacrylic acid, polyacrylamide, poly- (first
Base vinyl ethers/maleic acid) half-ester copolymerization object, polyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol, hydroxypropyl cellulose, hydroxyl
Ethyl cellulose, hydroxypropyl methyl cellulose, any one or a few mixture in sodium carboxymethylcellulose.
Based on the above technical solution, the body supports ingredient constitutes pedestal and syringe needle, the functional component point
It is dispersed in pedestal and syringe needle.
Based on the above technical solution, the syringe needle is in pyramid, cone or class cone.
Based on the above technical solution, any needle height is 50-1000 μm, and bottom diameter is 50-1000 μm, phase
The distance between two tips of adjacent two syringe needles are 100-2000 μm.
The disclosure additionally provides a kind of preparation method of microneedle patch for replenishing water and preserving moisture, includes the following steps：
(1) functional component is added to appropriate distilled water after mixing, stirring and dissolving is uniformly mixed at 60 DEG C, obtains function
The solution that composition quality score is 30% is imitated, is cooled to room temperature up to Effect raw material solution；
(2) degradation material is dissolved in water to obtain body supports solution, then the body supports solution is added
It is mixed into effect material solution in step (1), heating stirring is uniform, is cooled to room temperature to obtain premixed solution；
(3) by the premixed solution injection microneedle array mold in step (2), then vacuumize, it is dry after removing to get
To the microneedle patch for replenishing water and preserving moisture.
Based on the above technical solution, the degradation material mass fraction in the body supports solution is 10%.
Based on the above technical solution, the microneedle patch for replenishing water and preserving moisture obtained is in temperature 15~25
DEG C, sterile packaged is carried out in the confined space under the conditions of humidity 10%~30%.
Jojoba (jojoba) be originate in Arizona State, California and Mexico Sonora and
The shrub of Mojave.Jojoba extract has the beauty functions of highly significant to skin, has the function of balance skin, can
For dredging pore, it is adjustable the fat secretion of oiliness or Combination skin, or the grease of dissolution on the face, removes blackhead,
Improve the symptoms such as skin inflammation and sensitivity, eczema, chronic eczema, pimples.It moisten and moistening effect it is very good, can pre- anti-wrinkle and
Aging, it is very good to stemness, skin wrinkly, it can be made to rejuvenate and gloss.Jojoba in Jojoba extract
Oil is optimal medium oil, is suitble to any skin, can carry essential oil and go deep into skin, is optimal aesthetic nursing oil.It can change
Kind Oily and the skin of inflammation, make skin exquisiteness, water moisten, is full.
Herba Lysimachiae foenumgraeci extract can effectively eliminate color spot, skin whitening, moisten moisturizing, promote cytothesis, help flesh
Skin absorbs rapidly and locks moisture.Skin overdrying is excessively oily, is all due to caused by superficial water oil imbalance, lavender deep layer is adjusted
Skin ph, control table musculus cutaneus skin fat secretion restore the best shape of skin water and oil balance using superpower replenishing water and preserving moisture ingredient
State.
Amino acid, organic acid, polysaccharide and the microelement contained in aloe is all in skin natural moisturizing factor NMF
Ingredient.Polysaccharide component in aloe has the moistening effect of significant moisturizing and water lock to skin.The wet keeping machine of active aloe polysaccharide
System may is that it contains a large amount of polar groups such as hydroxyl, carboxyl etc., can form hydrogen bond with hydrone and be bonded water lock, while is more
Sugar subchain, which is interweaved, to be reticulated, to there is very strong water lock to act on.In addition polysaccharide has good film forming, can form one
The uniform film of layer reduces the moisture evaporation of epidermis, when moisture permeates into cuticula from substrate microstructure, can induce cuticula into
One step aquation, and the moisture of skin itself is saved, reach moisturizing effect.In addition, aloe polysaccharide with it is interior in skin extracellular matrix
Source property polysaccharide component and fibrous proteins collectively constitute extracellular gelatinised matrix, which contains large quantity of moisture, can mention for skin
Reach moisturizing effects for moisture.
Vitamin C, VitAVitE and potassium rich in, magnesium, cellulose in Chinese grooseberry, also containing folic acid,
Carrotene, calcium, lutern, amino acid and natural inositol, extract can increase the antioxidant concentration in skin, have
Anti-radiation, anti-oxidant, free radical resisting and anti-aging effects.
The main chemical compositions of the root of Dahurain angelica are cumarins and the volatile oil such as Imperatorin, Isomperatorin.Isomperatorin is
The main active constituent of the root of Dahurain angelica is related to the maintaining beauty and keeping young of the root of Dahurain angelica.Modern pharmacological research proves that Angelica Dahurica extract can improve
Local blood circulation eliminates the excess accumulation of pigment in the tissue, promotes skin cell metabolism, and then reach the work of beauty
With；And Angelica Dahurica extract has antibacterial and antifungic action, for keeping cleaning, the health of skin of face, prevents skin disease, energy
Generate certain effect.
Certain physiologically active ingredients in mung bean have antibacterial, bacteriostasis.Studies have shown that being rich in flavonoids in green gram spermoderm
Compound, is high-efficiency antioxidant ingredient, and antioxidant capacity is very strong.Mung bean flavonoid compounds as a kind of natural inhibitor,
Have the characteristics that safe and efficient.Rudiment mung bean polysaccharide has good scavenging effect to DPPH free radical, also has preferable anti-
Allergy effect and long-acting moisture-keeping efficacy.
Urea has good moisture-keeping functions, helps permeability there are also good, therefore can effectively repair epidermal barrier.Urea
It is present in the cuticula of skin, belongs to the main component of skin natural moisturizing factor NMF, the function with moisturizing and soft cutin
Effect can prevent cuticula blocked pore, improve acne problem, moreover it is possible to prevent chapped skin decortication phenomenon.
Ceramide is naturally present in the lipid in skin, is made of the sphingol base of long-chain and a fatty acid,
Since itself derives from skin, so ceramide is easy to penetrate into skin, in conjunction with the moisture in cuticula, formed netted
Structure can firmly lock skin moisture.In addition to powerful moisturizing water lock effect, ceramide is protected to impaired skin is repaired
Skin barrier also has good effect.
Compared with the prior art, the advantages of the present invention are as follows：
The microneedle patch of the disclosure can effectively pierce through skin, duct be formed in skin surface, with body supports ingredient
Degradation material dissolves in skin rapidly, and functional component may be absorbed by skin corium rapidly, keeps the skin wet and nutriment, from
Fundamentally improve skin exsiccosis, replenishing water and preserving moisture persistent enables the obvious rejuvenation of skin, and highly-safe.Of the invention
The preparation method of microneedle patch is simple, is easy to produce in batches.
Detailed description of the invention
Fig. 1 is the schematic diagram of the microneedle patch for replenishing water and preserving moisture in the embodiment of the present disclosure 1；
Fig. 2 is the dermoscopy photo a of the microneedle patch for replenishing water and preserving moisture in the embodiment of the present disclosure 4；
Fig. 3 is the dermoscopy photo b of the microneedle patch for replenishing water and preserving moisture in the embodiment of the present disclosure 4.
Specific embodiment
Microneedle array mold used is prepared by the following method to obtain in following embodiment：
By PDMS (dimethyl silicone polymer, Sylgard 184) and curing agent in mass ratio 10:1 is uniformly mixed, and then will
The mixture is poured over microneedles template surface, is evacuated to -0.1~-0.05MPa and removes bubble in mixture, then 75~
3~the 4h that is heating and curing at 80 DEG C solidifies PDMS, separates cured PDMS to get PDMS micropin is arrived with microneedles template after cooling
Array mold.
Embodiment 1
The embodiment of the present disclosure provides a kind of microneedle patch for replenishing water and preserving moisture, as shown in Figure 1, the microneedle patch includes master
Body support element and functional component, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.It is main
Body support element is the hyaluronic acid solution made of the hyaluronic acid with biocompatibility, and functional component percentage by weight contains
It measures composed of the following components：10% Jojoba extract, 5% Herba Lysimachiae foenumgraeci extract, 15% aloe extract, 10%
Unusual berry extract, 5% Angelica Dahurica extract, 10% Semen phaseoli radiati extract, 10% urea, 10% ceramide, 8%
Glycerol, 5% vitamin E, 2% ascorbic acid, 5% allantoin and 5% polysorbate60.The syringe needle of microneedle patch is in pyramid
Shape, cone or class cone, needle height are 50 μm, and bottom diameter is 50 μm, and the distance between two tips of two neighboring syringe needle are 100 μm.
The preparation method for the microneedle patch for replenishing water and preserving moisture that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, -0.05MPa is evacuated to and removes bubble in mixture, then be heating and curing 3 at 75~80 DEG C
~4h solidifies PDMS, separates cured PDMS to get PDMS microneedle array mold is arrived with microneedles template after cooling；Wherein,
The specification of microneedles template is as follows：The height of any one syringe needle is 50 μm, and bottom diameter is 50 μm, the distance between two tips of two neighboring syringe needle
It is 100 μm；
(2) Effect raw material solution is prepared：Weight percentage is taken to mention for 10% Jojoba extract, 5% lavender
Take object, 15% aloe extract, 10% unusual berry extract, 5% Angelica Dahurica extract, 10% Semen phaseoli radiati extract,
10% urea, 10% ceramide, 8% glycerol, 5% vitamin E, 2% ascorbic acid, 5% allantoin and
The above functional component is tentatively uniformly mixed by 5% polysorbate60, adds distilled water and stirring and dissolving mixes at 60 DEG C
It is even, the solution that functional component mass fraction is 30% is obtained, is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：Hyaluronic acid is taken to be configured to the hyaluronic acid solution that 100mg mass fraction is 10%, so
It will be mixed in effect material solution that the hyaluronic acid solution is added in 10mg step (2) afterwards, be heated to 75~80 DEG C, stirring
Uniformly, it is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array mold afterwards, which is placed on
It in the vacuum environment that temperature is 15 DEG C, vacuum degree is -0.05MPa, is taken out after being completely filled up it, then the drying at 15 DEG C
12h then removes PDMS microneedle array mold to get to the microneedle patch for being used for replenishing water and preserving moisture；
(5) step (4) obtained microneedle patch is carried out in the confined space under the conditions of 15 DEG C of temperature, humidity 10%
Sterile packaged.
Embodiment 2
The embodiment of the present disclosure provides a kind of microneedle patch for replenishing water and preserving moisture, including body supports ingredient and effect at
Point, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.Body supports ingredient is by having
PLA solution made of the polylactic acid of biocompatibility, functional component percentage composition by weight are composed of the following components：30%
Jojoba extract, 3% Herba Lysimachiae foenumgraeci extract, 25% aloe extract, 5% unusual berry extract, 2% root of Dahurain angelica
Extract, 5% Semen phaseoli radiati extract, 15% urea, 5% ceramide, 5% glycerol, 2% vitamin E, 2%
Ascorbic acid and 1% polysorbate40.The syringe needle of microneedle patch is 500 μ in pyramid, cone or class cone, needle height
M, bottom diameter are 500 μm, and the distance between two tips of two neighboring syringe needle are 1000 μm.
The preparation method for the microneedle patch for replenishing water and preserving moisture that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, -0.08MPa is evacuated to and removes bubble in mixture, then be heating and curing 3 at 75~80 DEG C
~4h solidifies PDMS, separates cured PDMS to get PDMS microneedle array mold is arrived with microneedles template after cooling；Wherein,
The specification of microneedles template is as follows：The height of any one syringe needle is 500 μm, and bottom diameter is 500 μm, the tip of two neighboring syringe needle away from
From being 1000 μm；
(2) functional component material solution is prepared：Take the Jojoba extract, 3% that weight percentage is 30% smokes clothing
Careless extract, 25% aloe extract, 5% unusual berry extract, 2% Angelica Dahurica extract, 5% Semen phaseoli radiati extract,
15% urea, 5% ceramide, 5% glycerol, 2% vitamin E, 2% ascorbic acid and 1% polysorbate40, will
The above functional component is tentatively uniformly mixed, and adds distilled water and stirring and dissolving is uniformly mixed at 60 DEG C, obtain functional component
The solution that mass fraction is 30% is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：It takes polylactic acid to be configured to the PLA solution that 100mg mass fraction is 10%, then will
It is mixed in effect material solution that the PLA solution is added in 10mg step (2), is heated to 75~80 DEG C, stirs evenly,
It is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array mold afterwards, which is placed on
It places in the vacuum environment that temperature is 15 DEG C, vacuum degree is -0.08MPa, is taken out after being completely filled up it, then done at 15 DEG C
Dry 12h then removes PDMS microneedle array mold to get to the microneedle patch for being used for replenishing water and preserving moisture；
(5) step (4) obtained microneedle patch is carried out in the confined space under the conditions of 20 DEG C of temperature, humidity 20%
Sterile packaged.
Embodiment 3
The embodiment of the present disclosure provides a kind of microneedle patch for replenishing water and preserving moisture, including body supports ingredient and effect at
Point, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.Body supports ingredient is by having
Maltose solution made of the maltose of biocompatibility, functional component percentage composition by weight are composed of the following components：20%
Jojoba extract, 4% Herba Lysimachiae foenumgraeci extract, 20% aloe extract, 8% unusual berry extract, 3% root of Dahurain angelica
Extract, 5% Semen phaseoli radiati extract, 15% urea, 5% ceramide, 8% glycerol, 2% ascorbic acid, 5%
Allantoin, 3% kojic acid and 2% polysorbas20.The syringe needle of microneedle patch is high in pyramid, cone or class cone, syringe needle
Degree is 1000 μm, and bottom diameter is 1000 μm, and the distance between two tips of two neighboring syringe needle are 2000 μm.
The preparation method for the microneedle patch for replenishing water and preserving moisture that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, then the bubble being evacuated in -0.1MPa removing mixture is heating and curing at 75~80 DEG C
3~4h solidifies PDMS, separates cured PDMS to get PDMS microneedle array mold is arrived with microneedles template after cooling；Wherein,
The specification of microneedles template is as follows：The height of any one syringe needle is 1000 μm, and bottom diameter is 1000 μm, the tip of two neighboring syringe needle
Distance is 2000 μm；
(2) Effect raw material solution is prepared：Taking weight percentage is 20% Jojoba extract, 4% lavender
Extract, 20% aloe extract, 8% unusual berry extract, 3% Angelica Dahurica extract, 5% Semen phaseoli radiati extract,
15% urea, 5% ceramide, 8% glycerol, 2% ascorbic acid, 5% allantoin, 3% kojic acid and 2%
The above functional component is tentatively uniformly mixed by polysorbas20, adds distilled water and stirring and dissolving is uniformly mixed at 60 DEG C, obtain
The solution that functional component mass fraction is 30% is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：It takes maltose to be configured to the maltose solution that 100mg mass fraction is 10%, then will
It is mixed in effect material solution that the maltose solution is added in 10mg step (2), is heated to 75~80 DEG C, stirs evenly,
It is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array mold afterwards, which is placed on
It in the vacuum environment that temperature is 15 DEG C, vacuum degree is -0.1MPa, takes out after being completely filled up it, is then done at 15 DEG C again
Dry 12h then removes PDMS microneedle array mold to get to the microneedle patch for being used for replenishing water and preserving moisture；
(5) step (4) obtained microneedle patch is carried out in the confined space under the conditions of 25 DEG C of temperature, humidity 30%
Sterile packaged.
Embodiment 4
The embodiment of the present disclosure provides a kind of microneedle patch for replenishing water and preserving moisture, including body supports ingredient and effect at
Point, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.Body supports ingredient is by having
Polyglycolic acid solution made of the polyglycolic acid of biocompatibility, functional component percentage composition by weight are composed of the following components：
18% Jojoba extract, 5% Herba Lysimachiae foenumgraeci extract, 15% aloe extract, 10% unusual berry extract, 3%
Angelica Dahurica extract, 6% Semen phaseoli radiati extract, 15% urea, 8% ceramide, 10% glycerol, 5% vitamin
E, 3% kojic acid and 2% squalene.The syringe needle of microneedle patch is conical in pyramid, cone or class, and needle height is
600 μm, bottom diameter is 300 μm, and the distance between two tips of two neighboring syringe needle are 500 μm.
The preparation method for the microneedle patch for replenishing water and preserving moisture that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, then the bubble being evacuated in -0.08MPa removing mixture heats solid at 75~80 DEG C
Changing 3~4h solidifies PDMS, separates cured PDMS to get PDMS microneedle array mold is arrived with microneedles template after cooling；Its
In, the specification of microneedles template is as follows：The height of any one syringe needle is 600 μm, and bottom diameter is 300 μm, the point of two neighboring syringe needle
End distance is 500 μm；
(2) Effect raw material solution is prepared：Weight percentage is taken to mention for 18% Jojoba extract, 5% lavender
Take object, 15% aloe extract, 10% unusual berry extract, 3% Angelica Dahurica extract, 6% Semen phaseoli radiati extract, 15%
Urea, 8% ceramide, 10% glycerol, 5% vitamin E, 3% kojic acid and 2% squalene, by the above function
It imitates ingredient to be tentatively uniformly mixed, adds distilled water and stirring and dissolving is uniformly mixed at 60 DEG C, obtain functional component quality point
The solution that number is 30% is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：Polyglycolic acid is taken to be configured to the polyglycolic acid solution that 100mg mass fraction is 10%, so
It will be mixed in effect material solution that the polyglycolic acid solution is added in 10mg step (2) afterwards, be heated to 75~80 DEG C, stirring
Uniformly, it is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array mold afterwards, which is placed on
Temperature is 15 DEG C, and vacuum degree is to take out after being completely filled up it in the vacuum environment of -0.08MPa, then dry at 15 DEG C
12h then removes PDMS microneedle array mold to get to the microneedle patch for being used for replenishing water and preserving moisture, as shown in Figures 2 and 3；
(5) step (4) obtained microneedle patch is carried out in the confined space under the conditions of 22 DEG C of temperature, humidity 25%
Sterile packaged.
Embodiment 5
The embodiment of the present disclosure provides a kind of microneedle patch for replenishing water and preserving moisture, including body supports ingredient and effect at
Point, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.Body supports ingredient is by having
Polyacrylic acid solution made of the polyacrylic acid of biocompatibility, functional component percentage composition by weight are composed of the following components：
25% Jojoba extract, 3% Herba Lysimachiae foenumgraeci extract, 15% aloe extract, 10% unusual berry extract, 2%
Angelica Dahurica extract, 5% Semen phaseoli radiati extract, 10% urea, 5% ceramide, 10% glycerol, 5% vitamin
E, 3% kojic acid, 2% squalene and 5% Tween 80.The syringe needle of microneedle patch is conical in pyramid, cone or class,
Needle height is 750 μm, and bottom diameter is 500 μm, and the distance between two tips of two neighboring syringe needle are 1000 μm.
The preparation method for the microneedle patch for replenishing water and preserving moisture that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, -0.1MPa is evacuated to and removes bubble in the mixture, then heated at 75~80 DEG C
3~4h of solidification solidifies PDMS, separates cured PDMS to get PDMS microneedle array mold is arrived with microneedles template after cooling；
Wherein, the specification of microneedles template is as follows：The height of any one syringe needle is 750 μm, and bottom diameter is 500 μm, two neighboring syringe needle
Distance between two tips are 1000 μm；
(2) Effect raw material solution is prepared：Weight percentage is taken to mention for 25% Jojoba extract, 3% lavender
Take object, 15% aloe extract, 10% unusual berry extract, 2% Angelica Dahurica extract, 5% Semen phaseoli radiati extract, 10%
Urea, 5% ceramide, 10% glycerol, 5% vitamin E, 3% kojic acid, 2% squalene and 5% tween
80, the above functional component is tentatively uniformly mixed, distilled water is added and stirring and dissolving is uniformly mixed at 60 DEG C, prepare successfully
The solution that composition quality score is 30% is imitated, is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：Polyacrylic acid is taken to be configured to the polyacrylic acid solution that 100mg mass fraction is 10%, so
It will be mixed in effect material solution that the polypropylene solution is added in 10mg step (2) afterwards, be heated to 75~80 DEG C, stirring is equal
It is even, it is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array mold afterwards, which is placed on
It in the vacuum environment that temperature is 15 DEG C, vacuum degree is -0.1MPa, takes out after being completely filled up it, is then done at 15 DEG C again
Dry 12h then removes PDMS microneedle array mold to get to the microneedle patch for being used for replenishing water and preserving moisture；
(5) obtained microneedle patch is subjected to sterile envelope in the confined space under the conditions of 18 DEG C of temperature, humidity 20%
Dress.
The present invention is not limited to the above-described embodiments, for those skilled in the art, is not departing from
Under the premise of the principle of the invention, several improvements and modifications can also be made, these improvements and modifications are also considered as protection of the invention
Within the scope of.The content being not described in detail in this specification belongs to the prior art well known to professional and technical personnel in the field.
Claims (9)
1. a kind of microneedle patch for replenishing water and preserving moisture, it is characterised in that：Including body supports ingredient and it is dispersed in body supports
Effect ingredient in ingredient, the body supports ingredient are made of the degradation material with biocompatibility, described effect at
Divide percentage composition by weight composed of the following components：Jojoba extract 10%~30%, Herba Lysimachiae foenumgraeci extract 3%~5%, reed
Luxuriant growth extract 15%~25%, unusual berry extract 5%~10%, Angelica Dahurica extract 2%~5%, Semen phaseoli radiati extract 5%~
10%, urea 10%~15%, ceramide 5%~10%, auxiliary additive 10%~25%.
2. a kind of microneedle patch for replenishing water and preserving moisture as described in claim 1, it is characterised in that：The auxiliary additive is
Glycerol, vitamin E, ascorbic acid, allantoin, kojic acid, salicylic acid, squalene, polysorbas20, polysorbate40, polysorbate60 and Tween 80
In any one or a few mixture.
3. a kind of microneedle patch for replenishing water and preserving moisture as described in claim 1, it is characterised in that：The degradation material is
Hyaluronic acid, maltose, chitosan, sodium chondroitin sulfate, sodium alginate, amylopectin, polylactic acid, polyglycolic acid, polyoxygenated
Ethylene, polyacrylamide, poly- (methyl vinyl ether/maleic acid) half-ester copolymerization object, polyvinylpyrrolidone, gathers polyacrylic acid
Ethylene glycol, polyvinyl alcohol, hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, in sodium carboxymethylcellulose
Any one or a few mixture.
4. a kind of microneedle patch for replenishing water and preserving moisture as described in claim 1, it is characterised in that：The body supports ingredient
It constitutes pedestal and syringe needle, the functional component is dispersed in pedestal and syringe needle.
5. a kind of microneedle patch for replenishing water and preserving moisture as claimed in claim 4, it is characterised in that：The syringe needle is in pyramid
Shape, cone or class cone.
6. a kind of microneedle patch for replenishing water and preserving moisture as claimed in claim 4, it is characterised in that：Any needle height
It is 50-1000 μm, bottom diameter is 50-1000 μm, and the distance between two tips of the two neighboring syringe needle are 100-2000 μm.
7. a kind of preparation method of the microneedle patch as claimed in any one of claims 1 to 6 for replenishing water and preserving moisture, feature exist
In including the following steps：
(1) Effect raw material solution is prepared：Functional component is added to appropriate distilled water after mixing, stirring and dissolving is mixed at 60 DEG C
It closes and uniformly obtains the solution that functional component mass fraction is 30%, be cooled to room temperature up to Effect raw material solution；
(2) premixed solution is prepared：Degradation material is dissolved in water to obtain body supports solution, then by the body supports
It is mixed in effect material solution that solution is added in step (1), heating stirring is uniform, is cooled to room temperature to obtain premixed solution；
(3) microneedle patch is prepared：By in the premixed solution injection microneedle array mold in step (2), then vacuumize, after dry
It removes to get the microneedle patch of replenishing water and preserving moisture is used for described in.
8. a kind of preparation method of the microneedle patch for replenishing water and preserving moisture as claimed in claim 7, it is characterised in that：The master
It is 10% that body, which supports the degradation material mass fraction in solution,.
9. a kind of preparation method of the microneedle patch for replenishing water and preserving moisture as claimed in claim 7, it is characterised in that：It obtains
The microneedle patch for replenishing water and preserving moisture carries out in the confined space under the conditions of 15~25 DEG C of temperature, humidity 10%~30%
Sterile packaged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810805019.1A CN108852963A (en) | 2018-07-20 | 2018-07-20 | A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810805019.1A CN108852963A (en) | 2018-07-20 | 2018-07-20 | A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108852963A true CN108852963A (en) | 2018-11-23 |
Family
ID=64303813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810805019.1A Pending CN108852963A (en) | 2018-07-20 | 2018-07-20 | A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108852963A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109693324A (en) * | 2018-12-27 | 2019-04-30 | 深圳职业技术学院 | A kind of production method of polymer micro needle mold |
| CN110664646A (en) * | 2019-11-14 | 2020-01-10 | 广州新济薇娜生物科技有限公司 | Composition with whitening effect, high-drug-loading-rate whitening soluble microneedle patch and preparation method thereof |
| CN111408047A (en) * | 2020-04-17 | 2020-07-14 | 南京鼓楼医院 | Conductive microneedle patch for wound repair and preparation method thereof |
| CN111544593A (en) * | 2019-03-26 | 2020-08-18 | 华中科技大学同济医学院附属协和医院 | Microneedle patch carrying anti-psoriasis systemic drug and preparation method thereof |
| CN115637279A (en) * | 2022-12-01 | 2023-01-24 | 翔鹏(北京)生物科技有限公司 | Recombinant human collagen for repairing skin and preparation method thereof |
| TWI809028B (en) * | 2019-01-14 | 2023-07-21 | 日商日寫股份有限公司 | Microneedle sheet and manufacturing method thereof |
-
2018
- 2018-07-20 CN CN201810805019.1A patent/CN108852963A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109693324A (en) * | 2018-12-27 | 2019-04-30 | 深圳职业技术学院 | A kind of production method of polymer micro needle mold |
| TWI809028B (en) * | 2019-01-14 | 2023-07-21 | 日商日寫股份有限公司 | Microneedle sheet and manufacturing method thereof |
| CN111544593A (en) * | 2019-03-26 | 2020-08-18 | 华中科技大学同济医学院附属协和医院 | Microneedle patch carrying anti-psoriasis systemic drug and preparation method thereof |
| CN110664646A (en) * | 2019-11-14 | 2020-01-10 | 广州新济薇娜生物科技有限公司 | Composition with whitening effect, high-drug-loading-rate whitening soluble microneedle patch and preparation method thereof |
| CN110664646B (en) * | 2019-11-14 | 2022-04-29 | 广州新济薇娜生物科技有限公司 | Composition with whitening effect, high-drug-loading-rate whitening soluble microneedle patch and preparation method thereof |
| CN111408047A (en) * | 2020-04-17 | 2020-07-14 | 南京鼓楼医院 | Conductive microneedle patch for wound repair and preparation method thereof |
| CN115637279A (en) * | 2022-12-01 | 2023-01-24 | 翔鹏(北京)生物科技有限公司 | Recombinant human collagen for repairing skin and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108852963A (en) | A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture | |
| CN110664635B (en) | Moisturizing and hydrating mask composition, mask and preparation method of mask | |
| CN103536452B (en) | Active collagen-beta-cyclodextrin facial mask and preparation method thereof | |
| CN102258442B (en) | Compound traditional Chinese medicine extract and application thereof to whitening, moisturizing and anti-aging skin care product | |
| CN107898699A (en) | A kind of flesh bottom Essence of the Herba Dendrobii extract containing iron sheet and preparation method thereof | |
| CN102293733A (en) | Overall whitening and speckle removal skin care product | |
| CN108904421A (en) | A kind of microneedle patch and preparation method thereof for anti-ageing smoothing wrinkle | |
| CN104800120B (en) | A kind of anti-ageing filling microgroove facial treatment essence liquid | |
| CN104971029A (en) | Whitening mask and preparation method thereof | |
| CN105193673B (en) | A kind of clear acne repairs liquid and preparation method thereof | |
| KR101533331B1 (en) | Method of Manufacturing Natural Liquid Soap for Skin | |
| CN104983647A (en) | Deep restoration mask and making method thereof | |
| CN104983648A (en) | Mask for repairing skin burnt by ultraviolet rays and preparation method thereof | |
| CN102274141B (en) | Herba selaginellae revival moisturizing cream and preparation method thereof | |
| CN108524414A (en) | A kind of more effect Chinese pitted skin films and its preparation process | |
| CN104983646A (en) | Night maintenance mask solution and preparation method thereof | |
| CN103585097A (en) | Epidermal growth factor-loaded bletilla rhizome polysaccharide compound, and preparation method and application thereof | |
| CN103341216A (en) | Scar-removing repairing material and preparation method thereof | |
| CN109620784A (en) | A kind of moist tightening cosmetic composition and its preparation method and application | |
| CN104739746A (en) | Pure natural nano plant facial mask | |
| CN105193685A (en) | Traditional Chinese foot caring solution, preparation method of traditional Chinese foot caring solution and traditional Chinese foot caring mask | |
| CN104352382A (en) | Essence | |
| CN103349637A (en) | Compound traditional Chinese medicine extract with effects of whitening and moisturizing, preparation method and application thereof | |
| CN103989601A (en) | Shining, moisturizing and skin-finishing cream and preparation method thereof | |
| CN104771340B (en) | A kind of facial mask of anti-ageing filling microgroove |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181123 |