CN103536452B - Active collagen-beta-cyclodextrin facial mask and preparation method thereof - Google Patents
Active collagen-beta-cyclodextrin facial mask and preparation method thereof Download PDFInfo
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- CN103536452B CN103536452B CN201310541251.6A CN201310541251A CN103536452B CN 103536452 B CN103536452 B CN 103536452B CN 201310541251 A CN201310541251 A CN 201310541251A CN 103536452 B CN103536452 B CN 103536452B
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Abstract
The invention provides an active collagen-beta-cyclodextrin facial mask and a preparation method thereof, belonging to the field of daily cosmetics. The preparation method comprises the steps of firstly, blending a beta-cyclodextrin solution of which the mass percent is 0.5-9% with natural active substances to prepare an embedded type beta-cyclodextrin solution containing the natural active substances; then, blending the embedded type beta-cyclodextrin solution with a collagen solution of which the mass percent is 1-30% to prepare a mixed solution of embedded type beta-cyclodextrin and collagen; defoaming the mixed solution, then injecting the mixed solution into a mold, freezing for 1-7 days at -20 DEG C; finally, performing freeze-drying to prepare a collagen-beta-cyclodextrin facial mask containing the natural active substances. The collagen-beta-cyclodextrin facial mask prepared by the preparation method is convenient to use, is safe and effective, and can embed a variety of natural active substances with different effects to achieve multiple effects of whitening skin, removing freckles, resisting wrinkles, repairing skin and the like. Besides, the mask is degradable, can not cause environmental pollution, and has a good market application prospect.
Description
Technical field
The present invention relates to daily cosmetics field.In particular to a kind of active collagen-beta-schardinger dextrin-facial film and preparation method thereof.
Background technology
U.S. is the topic that women is eternal.Along with era development, the life of people is become better and better, and increasing people starts to focus on the quality of life, especially women.So the application of cosmetics is more and more extensive, thus has driven the development of cosmetic science technology.Facial film is the one in daily cosmetics, by it to the of short duration laminating action by contact of face, and the air that temporarily isolation is extraneous and pollution.Isolation of short duration like this can improve skin temperature, and the pore of skin is expanded, and then promotes secretion and the metabolism of sweat gland, is conducive to the oil substances that skin gets rid of the metabolic noxious products of epidermis cell and accumulation.Simultaneously the oxygen content of skin can also be made to increase, the moisture in facial film infiltrates the horny layer of epidermis, makes skin become soft and naturally bright and high resilience.
In order to make facial film have more function, facial film of today mostly also containing various natural active matter to make facial film reach clean, convergence, whitening, moisturizing, the effect such as crease-resistant.But natural active matter is directly added in facial film mainly with blended form greatly by the facial film that the major part of selling on the market contains natural active matter, this can not make natural active matter play its due effect.Reason has two aspects: one, and a lot of natural active matter is as also unstable in tea polyphenols, beta-carotene etc., and its structure very easily changes under the impact of heat, air, light or chemical environment, thus loses its original function; Its two, some natural active matter causes the content of effective ingredient in facial film to be restricted as arbutin, vitamin E etc. because of its poorly water-soluble, does not thus also reach due effect.Therefore, improving the stability of natural active matter and dissolubility, to make it play its due effect be that we must not irrespective problem.
Beta-schardinger dextrin-is the cyclic oligosaccharide be formed by connecting with α-Isosorbide-5-Nitrae-glucoside bond by seven D type Glucopyranose .s.Because the glycosidic bond connecting glucose unit can not rotate freely, therefore beta-schardinger dextrin-molecule has slightly conically hollow cylinder three-dimensional ring structure.In the structure, in cavity because the shielding action being subject to c h bond defines hydrophobic region.Comparatively big uncork end (upper end) is by C
2and C
3secondary hydroxyl form, smaller opening end (lower end) is by C
6primary hydroxyl form, there is hydrophilic.Due to hydrophobic in beta-schardinger dextrin-, outer hydrophilic and cavity size this characteristic moderate, can be combined with many kinds of substance and form Host-guest inclusion complex.After beta-schardinger dextrin-and material form clathrate, guest molecule can be made from the impact such as light, oxygen in external environment, therefore can improve its stability.And, by beta-schardinger dextrin-, the hydrophobic part of material is wrapped up, improved the dissolubility of guest molecule by the hydrophilic of beta-schardinger dextrin-outside.Therefore beta-schardinger dextrin-can play the effects such as good protection, stable and solubilising to guest molecule.Beta-schardinger dextrin-is applied to cosmetic field embedding natural active matter, natural active matter just can be made from the impact such as light, oxygen in external environment, increase its stability, make it still can keep natural activity before use.In addition, the dissolubility of natural active matter can also be improved, make its content be enough to reach required concentration, play good effect.Therefore, the use of beta-schardinger dextrin-provides a good approach for natural active matter plays its due effect.
Collagen protein is the helical fiber albumen be made up of three peptide chains, comparatively horn of plenty of originating.According to the document delivered both at home and abroad and patent display, collagen protein is very conservative in evolution, and difference in genera is less, thus has fabulous adsorptivity and the compatibility to skin, also has good biodegradability and low antigenicity in addition.Find after deliberation, collagen protein has certain repair to ultraviolet injury, and in cosmetic formulations, has good compatibility, stability, antibiotic property and can block brown pigment generation.Meanwhile, collagen protein contains the hydrophilic groups such as a large amount of amino, hydroxyl, has good moisture-keeping function.In addition, collagen protein has skin-active reparation and moisturizing lock water in conjunction with white class use, increase substantially cuticular accretion rate, accelerates cell proliferation, repairs damaged cell, reduces the effect such as wrinkle and increase elasticity of skin, therefore, collagen protein has extremely important status at cosmetic field.
This method utilizes beta-schardinger dextrin-and natural active matter to form Host-guest inclusion complex, first makes the embedding type beta-schardinger dextrin-solution comprising natural active matter; Again by embedding type beta-schardinger dextrin-solution and collagen solution blended, make the mixed solution of embedding type beta-schardinger dextrin-and collagen protein; Finally above-mentioned blend solution deaeration is injected mould freezing 1 ~ 7 day, lyophilization makes the collagen protein-beta-schardinger dextrin-facial film comprising natural active matter.Active collagen prepared by the present invention-beta-schardinger dextrin-facial film is effectively easy to use, safe; And the natural active matter of multiple different efficacies can be embedded according to actual needs, reach whitening, speckle dispelling, crease-resistant, repair the multiple efficacies such as skin; Facial film degradable, can not cause environmental pollution, has good market application foreground.Up to the present, pertinent literature or invention is not yet had to carry out report to this research.
Summary of the invention
In order to make natural active matter in facial film play its due effect, the present invention adopts beta-schardinger dextrin-can improve guest molecule stability and this feature of dissolubility, makes active collagen-beta-schardinger dextrin-facial film with collagen protein by a series of process.
The present invention is achieved through the following technical solutions, and unless otherwise indicated, involved number is parts by weight, and percentage ratio is all weight percentage.
The invention provides a kind of active collagen-beta-schardinger dextrin-facial film, its preparation method is specific as follows:
(1) by 1 ~ 40 part of beta-schardinger dextrin-heating for dissolving in deionized water, preparation mass fraction is the beta-schardinger dextrin-solution of 0.5 ~ 9%, add 0.1 ~ 1 part of natural active matter after being cooled to room temperature immediately, stir 1 ~ 5 hour, make the embedding type beta-schardinger dextrin-solution comprising natural active matter;
(2) by embedding type beta-schardinger dextrin-solution and mass fraction be 1 ~ 30% collagen solution blending and stirring 1 ~ 5 hour, make the mixed solution of embedding type beta-schardinger dextrin-and collagen protein;
(3) will pour in mould ,-20 after above-mentioned mixed solution deaeration
ounder C freezing 1 ~ 7 day, lyophilization molding, must comprise the collagen protein-beta-schardinger dextrin-facial film of natural active matter.
In technique scheme, described active collagen-beta-schardinger dextrin-facial film, it is characterized in that described natural active matter is anti-oxidation active substance, resisting age of skin active substance, skin repairing activity material, freckle removing and whitening active substance, anti-ultraviolet radiation active substance, moisturising actives, the skin active substance that compacts, exfoliation active substance, be specially tea polyphenols, procyanidin, astaxanthin, lycopene, vitamin C, vitamin B
2, Citrin, beta-carotene, chlorogenic acid, kojic acid, fruit acid, VitAVitE, arbutin, shikonin, houttuynine sodium bisulfite, Semen Vitis viniferae extract, Punica granatum L. extract, Aloe extract, hamamelis extract, Radix Angelicae Sinensis extract, Radix Ginseng extract, Herba Lysimachiae foenum-graeci extract, Acai berry extract, any one or a few mixture in Fructus Canrii Albi extract.
In technique scheme, the ratio of natural active matter and beta-schardinger dextrin-counts 1:(1 ~ 400 by dry weight).
In technique scheme, the ratio of embedding type beta-schardinger dextrin-and collagen protein counts 1:(1 ~ 2000 by dry weight).
Active collagen provided by the invention-beta-schardinger dextrin-facial film, can embed the natural active matter of multiple different efficacies according to actual needs, reach whitening, speckle dispelling, crease-resistant, repair the multiple efficacies such as skin, be applied to daily cosmetics field.
Compared with the prior art the present invention, has many-sided good effect and advantage, specifically can inductive generalization as follows:
(1) active collagen provided by the invention-beta-schardinger dextrin-facial film, its base stock is natural material, nontoxic, non-stimulated, have no side effect; In addition, the aminoacid composition of collagen protein is similar with human body skin, has fabulous adsorptivity and the compatibility, and has good moisture-keeping functions, can also supplement the collagen protein of skin loss to skin;
(2) active collagen provided by the invention-beta-schardinger dextrin-facial film is by the bury function of beta-schardinger dextrin-, makes natural active matter from the impact such as light, oxygen in external environment, improves its stability; By being wrapped up by the hydrophobic part of natural active matter, improve its dissolubility by the hydrophilic of beta-schardinger dextrin-outside; And then make natural active matter give full play to its due effect;
(3) active collagen provided by the invention-beta-schardinger dextrin-facial film can embed multiple natural active matter simultaneously, comprise anti-oxidation active substance, resisting age of skin active substance, skin repairing activity material, freckle removing and whitening active substance, anti-ultraviolet radiation active substance, moisturising actives, the skin active substance that compacts, exfoliation active substance, be specially tea polyphenols, procyanidin, astaxanthin, lycopene, vitamin C, vitamin B
2, Citrin, beta-carotene, chlorogenic acid, kojic acid, fruit acid, VitAVitE, arbutin, shikonin, houttuynine sodium bisulfite, Semen Vitis viniferae extract, Punica granatum L. extract, Aloe extract, hamamelis extract, Radix Angelicae Sinensis extract, Radix Ginseng extract, Herba Lysimachiae foenum-graeci extract, Acai berry extract, any one or a few mixture in Fructus Canrii Albi extract;
(4) active collagen provided by the invention-beta-schardinger dextrin-facial film has good ductility, can extend arbitrarily by the facial characteristics different according to end user, and has good viscosity, and it is convenient to peel off;
(5) active collagen provided by the invention-beta-schardinger dextrin-facial film its preparation method is simple, easy to operate, beauty parlor can be widely used in, especially individual or home care is applicable to, making it fully absorb moisture is affixed on the face, therefore also can use in conjunction with the spraying of selling on the market or surfactant;
(6) active collagen provided by the invention-beta-schardinger dextrin-facial film compares easy degraded with traditional polyvinyl alcohol with polyvinylpyrrolidine facial film, can not cause environmental pollution, has more the excellent feature of environmental protection for daily cosmetics;
(7) active collagen provided by the invention-beta-schardinger dextrin-facial film has higher scientific and technological surcharge, have wide potential market, significant to the exploitation of daily cosmetics technology, there is higher economic benefit and social benefit, be worthy of popularization.
Detailed description of the invention
Provide three embodiments of the present invention below, by embodiment, the present invention is specifically described.What be necessary to herein means out is; embodiment is only for being further detailed the present invention; can not be interpreted as limiting the scope of the invention, the person skilled in the art in this field can make some nonessential improvement and adjustment according to the content of the invention described above.
In the following example, unless otherwise indicated, involved number is parts by weight, and percentage ratio is all weight percentage.
embodiment 110 parts of beta-schardinger dextrin-s are dissolved in heating for dissolving in 400 parts of deionized waters, after cooling immediately with 5 parts of natural active matter blending and stirring 2 hours, make the embedding type beta-schardinger dextrin-solution comprising natural active matter; Be the collagen solution blending and stirring 1 hour of 20% by 20 parts of embedding type beta-schardinger dextrin-solution and 2000 mass fractions, make the mixed solution of embedding type beta-schardinger dextrin-and collagen protein; By above-mentioned mixed solution evacuation and centrifugal degassing, pour in mould ,-20
ounder C freezing 3 days, lyophilization molding, must comprise the collagen protein-beta-schardinger dextrin-facial film of natural constituent.
embodiment 225 parts of beta-schardinger dextrin-s are dissolved in heating for dissolving in 500 parts of deionized waters, after cooling immediately with 1 part of natural active matter blending and stirring 1 hour, make the embedding type beta-schardinger dextrin-solution comprising natural active matter; Be the collagen solution blending and stirring 3 hours of 20% by 200 parts of embedding type beta-schardinger dextrin-solution and 1500 mass fractions, make the mixed solution of embedding type beta-schardinger dextrin-and collagen protein; By above-mentioned mixed solution evacuation and centrifugal degassing, pour in mould ,-20
ounder C freezing 4 days, lyophilization molding, must comprise the collagen protein-beta-schardinger dextrin-facial film of natural constituent.
embodiment 320 parts of beta-schardinger dextrin-s are dissolved in heating for dissolving in 500 parts of deionized waters, after cooling immediately with 5 parts of natural active matter blending and stirring 2 hours, make the embedding type beta-schardinger dextrin-solution comprising natural active matter; Be the collagen solution blending and stirring 2 hours of 5% by 100 parts of embedding type beta-schardinger dextrin-solution and 2000 parts of mass fractions, make the mixed solution of embedding type beta-schardinger dextrin-and collagen protein; By above-mentioned mixed solution evacuation and centrifugal degassing, pour in mould ,-20
ounder C freezing 3 days, lyophilization molding, must comprise the collagen protein-beta-schardinger dextrin-facial film of natural active matter.
embodiment 440 parts of beta-schardinger dextrin-s are dissolved in heating for dissolving in 400 parts of deionized waters, after cooling immediately with 8 parts of natural active matter blending and stirring 2 hours, make the embedding type beta-schardinger dextrin-solution comprising natural active matter; Be the collagen solution blending and stirring 2 hours of 30% by 50 parts of embedding type beta-schardinger dextrin-solution and 2000 parts of mass fractions, make the mixed solution of embedding type beta-schardinger dextrin-and collagen protein; By above-mentioned mixed solution evacuation and centrifugal degassing, pour in mould ,-20
ounder C freezing 4 days, lyophilization molding, must comprise the collagen protein-beta-schardinger dextrin-facial film of natural constituent.
Claims (2)
1. active collagen-beta-schardinger dextrin-facial film, is characterized in that preparation method is as follows:
(1) by 1 ~ 40 part of beta-schardinger dextrin-heating for dissolving in deionized water, preparation mass fraction is the beta-schardinger dextrin-solution of 0.5 ~ 9%, add 0.1 ~ 1 part of natural active matter after being cooled to room temperature immediately, stir 1 ~ 5 hour, make the embedding type beta-schardinger dextrin-solution comprising natural active matter;
(2) by embedding type beta-schardinger dextrin-solution and mass fraction be 1 ~ 30% collagen solution blending and stirring 1 ~ 5 hour, make the mixed solution of embedding type beta-schardinger dextrin-and collagen protein;
(3) will pour in mould ,-20 after above-mentioned mixed solution deaeration
ounder C freezing 1 ~ 7 day, lyophilization molding, must comprise the collagen protein-beta-schardinger dextrin-facial film of natural active matter;
The ratio of described natural active matter and beta-schardinger dextrin-counts 1:(1 ~ 400 by dry weight);
The ratio of described embedding type beta-schardinger dextrin-and collagen protein counts 1:(1 ~ 2000 by dry weight).
2. active collagen according to claim 1-beta-schardinger dextrin-facial film, is characterized in that described natural active matter is tea polyphenols, procyanidin, astaxanthin, lycopene, vitamin C, vitamin B
2, Citrin, beta-carotene, chlorogenic acid, kojic acid, fruit acid, vitamin A, arbutin, shikonin, houttuynine sodium bisulfite, Semen Vitis viniferae extract, Punica granatum L. extract, Aloe extract, hamamelis extract, Radix Angelicae Sinensis extract, Radix Ginseng extract, Herba Lysimachiae foenum-graeci extract, Acai berry extract, any one or a few mixture in Fructus Canrii Albi extract.
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| CN104622707B (en) * | 2015-01-12 | 2017-10-03 | 武汉轻工大学 | A kind of ursin/hydroxypropyl beta cyclodextrin clathrate and preparation method thereof |
| CN104622713B (en) * | 2015-01-26 | 2017-07-14 | 杭州易文赛生物技术有限公司 | A kind of cosmetic composition and preparation method thereof |
| CN104644512A (en) * | 2015-03-20 | 2015-05-27 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine for acne removing mask |
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| CN104824660B (en) * | 2015-04-08 | 2018-01-19 | 王书敏 | A kind of collagen saussurea involucrata small peptide effervescent tablet and preparation method thereof |
| CN104958223A (en) * | 2015-07-22 | 2015-10-07 | 覃雪欢 | Collagen mask |
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| CN108498370B (en) * | 2018-05-21 | 2020-08-14 | 北京化工大学 | Rutin-containing multifunctional facial mask and preparation method thereof |
| CN109771331B (en) * | 2019-04-01 | 2022-05-17 | 广州茱颜化妆品有限公司 | Composition for regulating skin collagen metabolism and application thereof |
| CN110638692A (en) * | 2019-10-30 | 2020-01-03 | 华南理工大学 | Facial mask liquid with acne inhibiting effect and preparation method thereof |
| CN115637279B (en) * | 2022-12-01 | 2023-03-21 | 翔鹏(北京)生物科技有限公司 | Recombinant human collagen for repairing skin and preparation method thereof |
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| RO112468B1 (en) * | 1996-10-07 | 1997-10-30 | Inst De Biolog Dezvoltarii | Cosmetic mask with regenerating and hydrating effect |
| KR100404868B1 (en) * | 2000-03-28 | 2003-11-15 | 김삼 | Stable retinol palmitate and cosmetic composition containing the same |
| CN100998574A (en) * | 2007-01-24 | 2007-07-18 | 王安邦 | Capsule of anti-free radical agent for oral administration or external use and method for producing said capsule |
| US8357129B2 (en) * | 2009-11-12 | 2013-01-22 | Physicans Products, Inc. | Skin rejuvenation system and method |
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