CN108852928A - A kind of anti-aging Shu Min moisturizing gel and preparation method thereof - Google Patents

A kind of anti-aging Shu Min moisturizing gel and preparation method thereof Download PDF

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CN108852928A
CN108852928A CN201810733457.1A CN201810733457A CN108852928A CN 108852928 A CN108852928 A CN 108852928A CN 201810733457 A CN201810733457 A CN 201810733457A CN 108852928 A CN108852928 A CN 108852928A
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王丹
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Taiyuan Blue Technology Co., Ltd.
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Taiyuan Orchid Technology LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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    • A61K8/9728Fungi, e.g. yeasts
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    • AHUMAN NECESSITIES
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • A61Q19/08Anti-ageing preparations
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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Abstract

Anti-aging Shu Min moisturizing gel of the present invention, is prepared from the following raw materials in parts by weight:210~240 parts of deionized water, 1~1.2 part of carbomer, 12~16 parts of butanediol, 3~4 parts of niacinamide, 0.6~0.8 part of pungent glycol, 1~1.2 part of hydroxypropyl starch phosphate, 0.9~1 part of lauryl glucoside, 0.6~0.8 part of the smooth olive oleate of sorb, 1~1.2 part of capsicum seed oil, 3~3.6 parts of raspberry seed oil, 1~1.2 part of polymer hyaluronic acid sodium, 1~1.2 part of low-numerator sodium hyaluronate, 4~4.8 parts of persimmon fermented extract, 3.6~4 parts of Gomphidius rutilus extract, 1.4~1.6 parts of bisabolol.Anti-aging Shu Min moisturizing gel of the present invention has Shu Min outstanding and anti-aging effects and excellent moisture-keeping efficacy.

Description

A kind of anti-aging Shu Min moisturizing gel and preparation method thereof
Technical field
The invention belongs to biology and technical field of cosmetic preparation, and in particular to a kind of anti-aging Shu Min moisturizing gel and its Preparation method.
Background technique
All the time, beautifying face and skin anti-aging preparation and its cosmetics are that world market is preferably sold, most One of product favored.For these years, it is constantly subjected to related discipline field, particularly medical cosmetology cosmetic science, shield The great attention and common concern in the fields such as skin health care and skin anti-aging.Have been developed that many kinds of, dosage form is various, beautiful jade at present The beautifying skin anti-aging cosmetics that thinkling sound meets the eye on every side.In fact, these are for the master in beautifying face and skin anti-aging cosmetics Want functional component, bioactive substance and natural drug monomer etc., it is most of be some such as skin moisturizers (hyaluronic acid, Hyalomitome amine, chitosan etc.) skin barrier renovation agent (ceramide, phosphatide, cholesterol etc.), skin-nourishing agent (protein, Helium base acid, polysaccharide etc.).Porcine HGF (epithelical cell growth factor and fibroblast growth factor etc.), antioxidant (superoxide dismutase and metallothionein etc.), estrogen (animal estrogen and phytoestrogen etc.), vitamins (dimension life Plain E and its derivative and vitamin C and its derivative etc.), microelement (selenium and germanium etc.) marine organism extract (fish glue from skin Former and roe collagen etc.), life inhereditary material (DNA DNASn Ribonucleic RNA etc.), Chinese medical extract (ginseng Saponin and Rhodosides etc.), plant extracts (tea polyphenols, anthocyanidin and pycnogenol) and natural whiting sun-screening agent (scutelloside And arbutin) etc..
Skin sensitivity is increasingly valued by people.In recent years cosmetic industry progressively towards advocate green, return Natural direction is returned to develop.The natural antiallergic active material containing unique effects is developed, and is added in cosmetics, is developed Natural antiallergic cosmetics, it has also become cosmetic industry develops one of most active theme.Nowadays it is applied to natural in cosmetics There are many antiallergic plant additive, are broadly divided into two major classes, and one kind is to extract effective component as raw material with natural plants sheet to answer For in cosmetics, mainly including chamomile, purslane, lavender etc.;Another kind of is from vegetable seeds, pulp and other parts Extracting resulting vegetable oil is that raw material is added in cosmetics, mainly includes blue dragonfly oil, Seabuckthorn Oil etc..
Summary of the invention
It is anti-with Shu Min outstanding and anti-aging effects and excellent moisture-keeping efficacy that the object of the present invention is to provide a kind of Aging Shu Min moisturizing gel and preparation method thereof.
Anti-aging Shu Min moisturizing gel of the present invention, is prepared from the following raw materials in parts by weight:210~240 parts of deionized water, 1~1.2 part of carbomer, 12~16 parts of butanediol, 3~4 parts of niacinamide, 0.6~0.8 part of pungent glycol, hydroxypropyl starch phosphate 1 ~1.2 parts, 0.9~1 part of lauryl glucoside, 0.6~0.8 part of the smooth olive oleate of sorb, 1~1.2 part of capsicum seed oil, cover basin 3~3.6 parts of seed oil, 1~1.2 part of polymer hyaluronic acid sodium, 1~1.2 part of low-numerator sodium hyaluronate, persimmon fermented extract 4~4.8 parts, 3.6~4 parts of Gomphidius rutilus extract, 1.4~1.6 parts of bisabolol.
As optimization, anti-aging Shu Min moisturizing gel is prepared from the following raw materials in parts by weight:240 parts of deionized water, 1 part of carbomer, 14 parts of butanediol, 3.2 parts of niacinamide, 0.7 part of pungent glycol, 1 part of hydroxypropyl starch phosphate, lauryl glucoside 0.9 part, 0.8 part of the smooth olive oleate of sorb, 1.1 parts of capsicum seed oil, 3.2 parts of raspberry seed oil, polymer hyaluronic acid sodium 1.1 Part, 1.1 parts of low-numerator sodium hyaluronate, 4.5 parts of persimmon fermented extract, 3.7 parts of Gomphidius rutilus extract, bisabolol 1.5 part.
The method for preparing anti-aging Shu Min moisturizing gel of the present invention, includes the following steps:
A, the carbomer of the parts by weight, butanediol are mixed, under the conditions of 55 DEG C~60 DEG C, with 300 revs/min of revolving speed Stirring 3~5 minutes is added 2/3rds deionized water, continues stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, It places 2~3 hours;
B, by the capsicum seed oil of the parts by weight, raspberry seed oil, polymer hyaluronic acid sodium, low-numerator sodium hyaluronate, mountain The deionized water of the smooth olive oleate of pears, in addition one third mixes, under the conditions of 70 DEG C~75 DEG C, with 700 revs/min turn Speed stirring 5~10 minutes;
C, the mixture in step b is slowly added into the mixture in step a, the hydroxypropyl of the parts by weight is then added Base starch phosphate, niacinamide, pungent glycol, persimmon fermented extract, Gomphidius rutilus extract, red does not have lauryl glucoside Medicine alcohol is stirred 5~10 minutes under the conditions of 60 DEG C~65 DEG C with 350 revs/min of revolving speed,.
In instant component, carbomer belongs to high molecular polymer, and thickener, gelling agent, emulsion stabilizer have good Transparency.Butanediol is very common in cosmetics, is one kind of polyalcohol, uses as solvent.Niacinamide has very high Whitening safety and a variety of skin-care effects are had both, also has its shortcoming certainly, the most important is exactly in its raw material Impurity component niacin can cause the stimulation of skin, some consumption may may lead with the product of high-content niacinamide it is rubescent Equal allergic phenomenas.Pungent glycol CAS:1117-86-8 has with bacteria resistance function, is skin conditioner, can play the role of it is soft and moist, And reach mild corrosion-resistant effect.Hydroxypropyl starch phosphate CAS:113894-92-1 controls viscosity as emulsion stabilizer. Lauryl glucoside belongs to the surfactant of alkyl glycosides, and the cleaning effect in alkyl glycosides is best, and blistering is fine and smooth, Also relatively milder simultaneously, it is also smaller to the irritation of skin and eyes.The smooth olive oleate of sorb emulsifies in cosmetics Agent uses, and belongs to non-ionic oleophilic emulsifier.It can make that type of latex type product is glossy, creaminess, it is frivolous, easily absorb, it is smooth. Gomphidius rutilus(Chroogomphidius viscidus)Extract is ethanol extract, be can be, but not limited to using following step It is rapid to obtain:After taking 40 DEG C of dries pulverizings of Gomphidius rutilus, according to 1:65% ethyl alcohol, heating stirring, frequency is added in 10 solid-liquid ratios 40kHz, power 250W ultrasonic wave, 60 DEG C of extraction 1h, filtering, the active carbon of addition mass fraction 0.5%, 6O DEG C of decoloration 0.5h, Centrifugal filtration obtains extracting solution, and concentration is freeze-dried to obtain the final product.Persimmon(Diospyros Kaki L.f)Extractive from fermentative is persimmon Sub- Pediococcus pentosaceus fermentation material.It can be, but not limited to obtain using following steps:1. crushing after persimmon is dried, 40 meshes are crossed, According to solid-liquid ratio 1:20 are added distilled water, and sterilizing obtains mixed-culture medium.2. taking the gloomy 100,000,000,000/g Pediococcus pentosaceus freeze-dried powder in Shaanxi Activation culture obtains bacterium solution;Strain activation and culture condition is 33 DEG C~37 DEG C, 160~180r/min shaken cultivation, incubation time It is 12~24 hours.3. activation bacterium solution is inoculated into mixed-culture medium, inoculum concentration is 1.5%~2.5%;Fermentation after inoculation Condition of culture is the same as activation culture condition;Incubation time is 12~24 hours, obtains fermentation liquid.4. after filtering fermentation liquor, ultrasonic extraction 3 Secondary, frequency 60kHz, power 330W are 30-60 minutes each;Then 8000r/min is centrifuged 10 minutes, takes supernatant, is depressurized dense Contracting obtains after dry.
Capsicum seed oil of the present invention, raspberry seed oil, polymer hyaluronic acid sodium, the compound composition moisturizing of low-numerator sodium hyaluronate System can be directed to the different levels of skin, and outer layer moisturizing, internal layer water lock, moisturizing layer by layer, water profit is glossy from inside to outside for skin. The compound composition Shu Min of Gomphidius rutilus extract, bisabolol, which repairs combination, has collaboration Shu Min effect outstanding, can improve The inflammation and allergic reaction of skin subside red and swollen, repair skin.Persimmon fermented extract has reduction lipid peroxidation product (MDA) it generates, improve antioxidase (SOD) active effect, to reduce the smoothness that wrinkle improves skin.Therefore, this hair Bright anti-aging Shu Min moisturizing gel has Shu Min outstanding and anti-aging effects and excellent moisture-keeping efficacy.
Specific embodiment
The embodiments given below are intended to further illustrate the invention, but is not to be construed as to the scope of the present invention Limitation, content still falls within this to some nonessential modifications and adaptations of the invention to those skilled in the art according to the present invention The protection scope of invention.
Embodiment 1:The preparation method of anti-aging Shu Min moisturizing gel, includes the following steps:
A, by 10 grams of carbomer, 140 grams of butanediol mixing, under the conditions of 55 DEG C~60 DEG C, 3 are stirred with 300 revs/min of revolving speed ~5 minutes, 1600 grams of deionized waters are added, continue stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, it is small that 2~3 are placed When;
B, by 11 grams of capsicum seed oil, 32 grams of raspberry seed oil, molecular weight >=1,800 11 grams of kDa polymer hyaluronic acid sodium, molecule 8 grams, the 800 grams deionized water mixing of the smooth olive oleate of 11 grams of the kDa of 200 kDa~400 low-numerator sodium hyaluronate, sorb are measured, Under the conditions of 70 DEG C~75 DEG C, stirred 5~10 minutes with 700 revs/min of revolving speed;
C, the mixture in step b is slowly added into the mixture in step a, 32 grams of niacinamide, pungent glycol 7 is then added Gram, 10 grams of hydroxypropyl starch phosphate, 9 grams of lauryl glucoside, 45 grams of persimmon fermented extract, Gomphidius rutilus extract 37 Gram, 15 grams of bisabolol, under the conditions of 60 DEG C~65 DEG C, stirred 5~10 minutes with 350 revs/min of revolving speed,.
Embodiment 2:The preparation method of anti-aging Shu Min moisturizing gel, includes the following steps:
A, by 10 grams of carbomer, 120 grams of butanediol mixing, under the conditions of 55 DEG C~60 DEG C, 3 are stirred with 300 revs/min of revolving speed ~5 minutes, 1400 grams of deionized waters are added, continue stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, it is small that 2~3 are placed When;
B, by 10 grams of capsicum seed oil, 30 grams of raspberry seed oil, molecular weight >=1,800 10 grams of kDa polymer hyaluronic acid sodium, molecule 6 grams, the 700 grams deionized water mixing of the smooth olive oleate of 10 grams of the kDa of 200 kDa~400 low-numerator sodium hyaluronate, sorb are measured, Under the conditions of 70 DEG C~75 DEG C, stirred 5~10 minutes with 700 revs/min of revolving speed;
C, the mixture in step b is slowly added into the mixture in step a, 30 grams of niacinamide, pungent glycol 6 is then added Gram, 10 grams of hydroxypropyl starch phosphate, 9 grams of lauryl glucoside, 40 grams of persimmon fermented extract, Gomphidius rutilus extract 36 Gram, 14 grams of bisabolol, under the conditions of 60 DEG C~65 DEG C, stirred 5~10 minutes with 350 revs/min of revolving speed,.
Embodiment 3:The preparation method of anti-aging Shu Min moisturizing gel, includes the following steps:
A, by 12 grams of carbomer, 160 grams of butanediol mixing, under the conditions of 55 DEG C~60 DEG C, 3 are stirred with 300 revs/min of revolving speed ~5 minutes, 1600 grams of deionized waters are added, continue stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, it is small that 2~3 are placed When;
B, by 12 grams of capsicum seed oil, 36 grams of raspberry seed oil, molecular weight >=1,800 12 grams of kDa polymer hyaluronic acid sodium, molecule 8 grams, the 800 grams deionized water mixing of the smooth olive oleate of 12 grams of the kDa of 200 kDa~400 low-numerator sodium hyaluronate, sorb are measured, Under the conditions of 70 DEG C~75 DEG C, stirred 5~10 minutes with 700 revs/min of revolving speed;
C, the mixture in step b is slowly added into the mixture in step a, 40 grams of niacinamide, pungent glycol 8 is then added Gram, 12 grams of hydroxypropyl starch phosphate, 10 grams of lauryl glucoside, 48 grams of persimmon fermented extract, Gomphidius rutilus extract 40 grams, 16 grams of bisabolol are stirred 5~10 minutes under the conditions of 60 DEG C~65 DEG C with 350 revs/min of revolving speed,.
Comparative example 1:The preparation method of gel, includes the following steps:
A, by 12 grams of carbomer, 160 grams of butanediol mixing, under the conditions of 55 DEG C~60 DEG C, 3 are stirred with 300 revs/min of revolving speed ~5 minutes, 1600 grams of deionized waters are added, continue stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, it is small that 2~3 are placed When;
B, by 12 grams of capsicum seed oil, 36 grams of raspberry seed oil, molecular weight >=1,800 11 grams of kDa polymer hyaluronic acid sodium, molecule 8 grams, the 800 grams deionized water mixing of the smooth olive oleate of 11 grams of the kDa of 200 kDa~400 low-numerator sodium hyaluronate, sorb are measured, Under the conditions of 70 DEG C~75 DEG C, stirred 5~10 minutes with 700 revs/min of revolving speed;
C, the mixture in step b is slowly added into the mixture in step a, 40 grams of niacinamide, pungent glycol 8 is then added Gram, 12 grams of hydroxypropyl starch phosphate, 10 grams of lauryl glucoside, 48 grams of persimmon fermented extract, 16 grams of bisabolol, 60 DEG C~65 DEG C under the conditions of, stirred 5~10 minutes with 350 revs/min of revolving speed,.
Comparative example 2:The preparation method of gel, includes the following steps:
A, by 12 grams of carbomer, 160 grams of butanediol mixing, under the conditions of 55 DEG C~60 DEG C, 3 are stirred with 300 revs/min of revolving speed ~5 minutes, 1600 grams of deionized waters are added, continue stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, it is small that 2~3 are placed When;
B, by 12 grams of capsicum seed oil, 36 grams of raspberry seed oil, molecular weight >=1,800 11 grams of kDa polymer hyaluronic acid sodium, molecule 8 grams, the 800 grams deionized water mixing of the smooth olive oleate of 11 grams of the kDa of 200 kDa~400 low-numerator sodium hyaluronate, sorb are measured, Under the conditions of 70 DEG C~75 DEG C, stirred 5~10 minutes with 700 revs/min of revolving speed;
C, the mixture in step b is slowly added into the mixture in step a, 40 grams of niacinamide, pungent glycol 8 is then added Gram, 12 grams of hydroxypropyl starch phosphate, 10 grams of lauryl glucoside, 48 grams of persimmon fermented extract, Gomphidius rutilus extract It 40 grams, under the conditions of 60 DEG C~65 DEG C, is stirred 5~10 minutes with 350 revs/min of revolving speed,.
Comparative example 3:The preparation method of gel, includes the following steps:
A, by 12 grams of carbomer, 160 grams of butanediol mixing, under the conditions of 55 DEG C~60 DEG C, 3 are stirred with 300 revs/min of revolving speed ~5 minutes, 1600 grams of deionized waters are added, continue stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, it is small that 2~3 are placed When;
B, by 36 grams of raspberry seed oil, molecular weight >=1,800 12 grams of kDa polymer hyaluronic acid sodium, 200 kDa~400 of molecular weight 8 grams, 800 grams deionized water mixing of the smooth olive oleate of 12 grams of kDa low-numerator sodium hyaluronate, sorb, in 70 DEG C~75 DEG C items Under part, stirred 5~10 minutes with 700 revs/min of revolving speed;
C, the mixture in step b is slowly added into the mixture in step a, 40 grams of niacinamide, pungent glycol 8 is then added Gram, 12 grams of hydroxypropyl starch phosphate, 10 grams of lauryl glucoside, 48 grams of persimmon fermented extract, Gomphidius rutilus extract 40 grams, 16 grams of bisabolol are stirred 5~10 minutes under the conditions of 60 DEG C~65 DEG C with 350 revs/min of revolving speed,.
Comparative example 4:The preparation method of gel, includes the following steps:
A, by 12 grams of carbomer, 160 grams of butanediol mixing, under the conditions of 55 DEG C~60 DEG C, 3 are stirred with 300 revs/min of revolving speed ~5 minutes, 1600 grams of deionized waters are added, continue stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, it is small that 2~3 are placed When;
B, by 12 grams of capsicum seed oil, molecular weight >=1,800 12 grams of kDa polymer hyaluronic acid sodium, 200 kDa~400 of molecular weight 8 grams, 800 grams deionized water mixing of the smooth olive oleate of 12 grams of kDa low-numerator sodium hyaluronate, sorb, in 70 DEG C~75 DEG C items Under part, stirred 5~10 minutes with 700 revs/min of revolving speed;
C, the mixture in step b is slowly added into the mixture in step a, 40 grams of niacinamide, pungent glycol 8 is then added Gram, 12 grams of hydroxypropyl starch phosphate, 10 grams of lauryl glucoside, 48 grams of persimmon fermented extract, Gomphidius rutilus extract 40 grams, 16 grams of bisabolol are stirred 5~10 minutes under the conditions of 60 DEG C~65 DEG C with 350 revs/min of revolving speed,.
Comparative example 5:The preparation method of gel, includes the following steps:
A, by 10 grams of carbomer, 120 grams of butanediol mixing, under the conditions of 55 DEG C~60 DEG C, 3 are stirred with 300 revs/min of revolving speed ~5 minutes, 1400 grams of deionized waters are added, continue stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, it is small that 2~3 are placed When;
B, by 10 grams of capsicum seed oil, 30 grams of raspberry seed oil, molecular weight >=1,800 10 grams of kDa polymer hyaluronic acid sodium, molecule 6 grams, the 700 grams deionized water mixing of the smooth olive oleate of 10 grams of the kDa of 200 kDa~400 low-numerator sodium hyaluronate, sorb are measured, Under the conditions of 70 DEG C~75 DEG C, stirred 5~10 minutes with 700 revs/min of revolving speed;
C, the mixture in step b is slowly added into the mixture in step a, 30 grams of niacinamide, pungent glycol 6 is then added Gram, 10 grams of hydroxypropyl starch phosphate, 9 grams of lauryl glucoside, 36 grams of Gomphidius rutilus extract, 14 grams of bisabolol, Under the conditions of 60 DEG C~65 DEG C, stirred 5~10 minutes with 350 revs/min of revolving speed,.
Relevant comparative's test:Moistening effect test, chooses 150 triers altogether, is divided into 5 groups, every group of 30 people are respectively adopted Embodiment 1,3, the gel products in glycerol, comparative example 3-4.Daily twice with the coating of 1.8 μ l/cm2 coating even density, one Test result after month calculates average value.Using 825 moisture tester of Corneometer CM, measurement range is from 0 to 120 A.C.U..Test result is shown in Table 1 after one month.By the test group of the visible embodiment 1,3 of table 1, moistening effect is obviously better than it His group.
Anti-aging test:150 triers are chosen altogether, are divided into 5 groups, embodiment 1-3 and comparison is respectively adopted in every group of 30 people Gel products, glycerol in example 5, test position is two sides cheek and canthus, daily with 1.8 μ l/cm2 coating even density coating Twice, test result after one month calculates average value.It is measured using MicroSkinII Multi-functional skin mirror image analysis system Skin mean roughness and wrinkle mean depth numerical value change.By the test group of the visible embodiment 1-3 of table 2, use one month Afterwards, there are significant differences with respect to initial value for skin mean roughness and skin mean depth(p <O. 05).
Shu Min measure of merit:150 triers are chosen altogether, are divided into 5 groups, embodiment 1-2 is respectively adopted in every group of 30 people, right Gel products and glycerol in ratio 1-2 are tested using human body patch, and back spinal two sides skin is tested portion in selection Position;It then will be added with the bottom-up patch jail of the spot tester adhesive tape of spot examination object;The patch test time is 48 h;After sticking after 48 h, Spot tester is removed, observes recipient site skin condition, log after 30 min.Pass through the survey of the visible embodiment 1,2 of table 3 Examination group, sensitization rate index are obviously better than other groups.
Persimmon fermented extract is persimmon Pediococcus pentosaceus fermentation material.1. being crushed after persimmon is dried, 40 meshes are crossed, are pressed Take care of liquor ratio 1:20 are added distilled water, sterilizing.2. taking the gloomy 100,000,000,000/g Pediococcus pentosaceus freeze-dried powder activation culture in Shaanxi, bacterium is obtained Liquid;Strain activation and culture condition is 33 DEG C~37 DEG C, 160~180r/min shaken cultivation, and incubation time is 12~24 hours.3. Activation bacterium solution is inoculated with, inoculum concentration is 1.5%~2.5%;Fermentation culture conditions after inoculation are the same as activation culture condition;When culture Between be 12~24 hours.It is ultrasonic extraction 3 times, frequency 60kHz, power 330W, 30-60 minutes each 4. after filtering fermentation liquor; Then 8000r/min is centrifuged 10 minutes, takes supernatant, is concentrated under reduced pressure into medicinal extract.
Using natural aging mouse as research object, with back of mice skin histology homogenate in superoxide dismutase (SOD), Malonaldehyde (MDA) and lipofuscin (LF) are index, test actual effect of the persimmon fermented extract in terms of anti aging effect.Point For control group 1, glycerol;Experimental group 1, persimmon fermented extract concentrations are 15%;Control group 2, three groups of butanediol.Back is taken to lose hair or feathers About 0.5 g of skin histology block afterwards, pre-cooled 0.9% sodium chloride solution rinsing, removes subcutaneous fat and other connective tissues, filter paper Wipe dry, weighed quality, tissue block pours into homogenate tube after shredding, and 0.9% sodium chloride of pre-cooling of 9 times of quality of tissue block is added 10% tissue homogenate (carrying out in ice water) is made with interior cut type tissue refiner in solution, and then multigelation 3 times keep its complete Complete broken, cellular content dissociates in the liquid phase completely.The index parameters such as SOD activity, MDA content, skin LF in Skin Homogenate, Bio-engineering corporation's kit specification method is built up referring to Nanjing to be measured, and the results are shown in Table 4.It can be seen that the SOD of experimental group 1 Activity is obviously improved compared with control group, (P<0.01), and the content of MDA, LF substantially reduce (P<0.01).

Claims (3)

1. a kind of anti-aging Shu Min moisturizing gel, it is characterised in that be to be prepared from the following raw materials in parts by weight:Deionized water 210 ~240 parts, 1~1.2 part of carbomer, 12~16 parts of butanediol, 3~4 parts of niacinamide, 0.6~0.8 part of pungent glycol, hydroxypropyl shallow lake 1~1.2 part of powder phosphate, 0.9~1 part of lauryl glucoside, 0.6~0.8 part of the smooth olive oleate of sorb, capsicum seed oil 1~ 1.2 parts, 3~3.6 parts of raspberry seed oil, 1~1.2 part of polymer hyaluronic acid sodium, 1~1.2 part of low-numerator sodium hyaluronate, persimmon 4~4.8 parts of extractive from fermentative, 3.6~4 parts of Gomphidius rutilus extract, 1.4~1.6 parts of bisabolol.
2. anti-aging Shu Min moisturizing gel according to claim 1, it is characterised in that be by the raw material of following parts by weight It is made:240 parts of deionized water, 1 part of carbomer, 14 parts of butanediol, 3.2 parts of niacinamide, 0.7 part of pungent glycol, hydroxypropul starch phosphorus 1 part of acid esters, 0.9 part of lauryl glucoside, 0.8 part of the smooth olive oleate of sorb, 1.1 parts of capsicum seed oil, 3.2 parts of raspberry seed oil, 1.1 parts of polymer hyaluronic acid sodium, 1.1 parts of low-numerator sodium hyaluronate, 4.5 parts of persimmon fermented extract, Gomphidius rutilus mention Take 3.7 parts of object, 1.5 parts of bisabolol.
3. a kind of method for preparing anti-aging Shu Min moisturizing gel as claimed in claim 1 or 2, it is characterised in that including following step Suddenly:
A, the carbomer of the parts by weight, butanediol are mixed, under the conditions of 55 DEG C~60 DEG C, with 300 revs/min of revolving speed Stirring 3~5 minutes is added 2/3rds deionized water, continues stirring 3~5 minutes;Then under the conditions of 45 DEG C~50 DEG C, It places 2~3 hours;
B, by the capsicum seed oil of the parts by weight, raspberry seed oil, polymer hyaluronic acid sodium, low-numerator sodium hyaluronate, mountain The deionized water of the smooth olive oleate of pears, in addition one third mixes, under the conditions of 70 DEG C~75 DEG C, with 700 revs/min turn Speed stirring 5~10 minutes;
C, the mixture in step b is slowly added into the mixture in step a, the hydroxypropyl of the parts by weight is then added Base starch phosphate, niacinamide, pungent glycol, persimmon fermented extract, Gomphidius rutilus extract, red does not have lauryl glucoside Medicine alcohol is stirred 5~10 minutes under the conditions of 60 DEG C~65 DEG C with 350 revs/min of revolving speed,.
CN201810733457.1A 2018-07-06 2018-07-06 A kind of anti-aging Shu Min moisturizing gel and preparation method thereof Withdrawn CN108852928A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112266424A (en) * 2020-10-27 2021-01-26 北京林业大学 Modified plant polysaccharide and application thereof in cosmetics
CN114585349A (en) * 2019-08-27 2022-06-03 拜尔斯道夫股份有限公司 Natural oil substitute for cosmetic preparations

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114585349A (en) * 2019-08-27 2022-06-03 拜尔斯道夫股份有限公司 Natural oil substitute for cosmetic preparations
CN112266424A (en) * 2020-10-27 2021-01-26 北京林业大学 Modified plant polysaccharide and application thereof in cosmetics

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