CN108836938A - A kind of environment-friendly composite foam hoof bath foam and preparation method thereof - Google Patents

A kind of environment-friendly composite foam hoof bath foam and preparation method thereof Download PDF

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Publication number
CN108836938A
CN108836938A CN201811067302.5A CN201811067302A CN108836938A CN 108836938 A CN108836938 A CN 108836938A CN 201811067302 A CN201811067302 A CN 201811067302A CN 108836938 A CN108836938 A CN 108836938A
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China
Prior art keywords
foam
hoof
hoof bath
environment
friendly composite
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CN201811067302.5A
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CN108836938B (en
Inventor
薛改勤
李旭
保全福
张勃
王亮
樊文斌
冀婷婷
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Shaanxi Hanlong Cleaning And Disinfecting Products Co Ltd
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Shaanxi Hanlong Cleaning And Disinfecting Products Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Abstract

The invention belongs to animal dip technical field, a kind of environment-friendly composite foam hoof bath foam and preparation method thereof is specifically disclosed, includes following components：1 ~ 20 part of glutaraldehyde, 1 ~ 20 part of quaternary ammonium salt, 0.1 ~ 0.3 part of nano silver list, 1 ~ 15 part of foaming agent, 0.5 ~ 5 part of foam stabilizer, 8 ~ 10 parts of polyalcohol, 0.1 ~ 0.6 part of pigment, 10 ~ 30 parts of deionized water；Preparation gained foam hoof bath foam keeps stabilization not freeze at low ambient temperatures, and conducive to the use and storage of hoof bath foam, the sterilization component contained is detained the longer time at sufferer, between slowly penetrating animal hoof toe, directly acts at sufferer, effectively killing germ.

Description

A kind of environment-friendly composite foam hoof bath foam and preparation method thereof
Technical field
The invention belongs to animal dip technical fields, and in particular to a kind of animal hoof bath foam more particularly to a kind of environmental protection Composite foam hoof bath foam and preparation method thereof.
Background technique
Milk cow hoof disease is the principal disease for influencing milk cow health, is the general name of milk cow four limbs and hoof disease, and hoof disease occurs for milk cow Afterwards, it may appear that feeling of pain, limping etc., milk yield reduce；Serious meeting arthro-empyesis, sleeping ground do not rise, and influence milk cow health development, It even eliminates, brings huge economic loss to milk aquaculture, affect the sound development of cow estate.Therefore to milk cow hoof Sick to reinforce control measure, hoof bath is the current best method for solving Milk cow hoof disease, is worked by cleaning and cow hoof disinfection, can Effectively reduce the disease incidence of hoof disease.
Common hoof bath foam is still formalin and copper-bath in the market, and formalin irritation is big, toxicity Greatly, it is affected for illness milk cow, gradually has the tendency that withdrawing from the market；And copper-bath, bioavailability are low, meet Organic matter easy in inactivation, and belong to heavy metal, environmental pollution is than more serious.
With the development of animal husbandry, in addition reinforcement of the people to Milk cow hoof disease prevention and treatment consciousness, also occurs some in the market Novel hoof bath foam, have sterilizing act on and it is environmentally friendly.But there are still certain defects：（1）Excrement and hoof when milk cow hoof is bathed Portion's foul is easy to pollution pond herb liquid, and hoof bath foam is caused to fail, and reduces to claw ill affected part function and effect, increases milk cow and supports Grow the cost of industry；（2）Liquid solution adhesiveness is limited and easy evaporation, and sterilizing action time is short, and medical fluid has little time to permeate At injury or cow hoof dead angle；（3）Milk cow is easy to take out of medical fluid when crossing hoof bathing pool, will cause ground while wasting medical fluid It is wet and slippery, the risk that milk cow slips is increased, and then cause the pollution of cow breast, or even pollute to milk.
Summary of the invention
The invention discloses a kind of environment-friendly composite foam hoof bath foams and preparation method thereof, and gained hoof bath foam adhesion is good, Safe and efficient, permeability is strong, and foam is fine and smooth, and stability is good not-easy-to-freeze at low temperature.
In order to achieve the above objectives, technical solution of the present invention is as follows：
A kind of environment-friendly composite foam hoof bath foam, it is characterised in that：The environment-friendly composite foam hoof bath foam is by following weight The group of part is grouped as：
1 ~ 20 part of glutaraldehyde
1 ~ 20 part of quaternary ammonium salt
0.1 ~ 0.3 part of nano silver simple substance
1 ~ 15 part of foaming agent
0.5 ~ 5 part of foam stabilizer
8 ~ 10 parts of polyalcohol
0.1 ~ 0.6 part of pigment
10 ~ 30 parts of deionized water
Wherein, the quaternary ammonium salt is benzalkonium bromide, benzalkonium chloride, dodecyl trimethyl ammonium chloride, polyquaternium or double quaternary ammoniums Any one of salt or by wherein any two kinds press 1:1~1:3 ratio mixes；
Wherein, the foam stabilizer is guar gum and its derivative nonionic guar gum, cation guar gum, amphoteric ion Guar Glue, methyl cellulose ether and its derivative ethoxyl methyl cellulose ether, hydroxypropyl methyl cellulose ether, ethylmethylcellulose Ether, carboxy methyl cellulose ether, any one of cellulose ether, polyethylene glycol stearate or by wherein any two Kind presses 1:2~1:10 ratio mixes；
Wherein, the polyalcohol be ethyl alcohol, it is ethylene glycol, propylene glycol, glycerine, butanediol, any in hexylene glycol or by it In any two kinds mix in any proportion.
Preferably, the foaming agent is Tea Saponin, saponin, fatty alcohol polyoxyethylene ether, ethoxylated dodecyl alcohol, rouge Fat amide polyoxyethylene ether, fatty acid distribution of coconut oil diglycollic amide, cocoamidopropyl dimethyl glycine betaine, cocamidopropyl propyl amide hydroxyl Any one of sulphonic acid betaine, dodecyldimethyl ammonium oxide, alkyl polyglycoside or by wherein any two kinds press 1:1~ 1:5 ratio mixes.
Preferably, the pigment be brilliant blue, acid blue, sapphire blue, gardenia blue, it is positive blue, indigo in any group or combinations thereof.
A kind of preparation method of the environment-friendly composite foam hoof bath foam comprises the steps of：
（1）Glutaraldehyde, quaternary ammonium salt, nano silver simple substance, foaming agent and foam stabilizer are weighed by weight, are added to and are weighed by weight Polyol liquid in, stir 1min, formed dispersion；
（2）Pigment and deionized water are weighed by weight, by pigment and step（1）It prepares dispersions obtained system and is added to deionization In water, after stirring 30min, 1h is stood to get environment-friendly composite foam hoof bath foam.
Application method：Preparation gained environment-friendly composite foam hoof bath foam is diluted by 2% mass concentration, it is rear with special After being foamed with foaming machine i.e. can be used, hoof bath can be carried out, can also direct spraying in cow hoof patient part.
Beneficial effect of the present invention：
（1）The present invention is cooperated as foam stabilizer with foaming agent with guar gum and its derivative, methyl cellulose ether and its derivative It uses, can effectively extend the stability time of foam, when the sterilization component contained in hoof bath foam being made to be detained longer at sufferer Between, it between slowly penetrating animal hoof toe, directly acts at sufferer, effectively killing germ；Foaming agent in component also can produce greatly Fine and smooth foam is measured, the utilization rate and its stability of sterilization component can be effectively improved；
（2）The polyalcohol that the present invention uses can not only play the role of moisturizing, moisten at animal hoof quotient official, can in bath foam system It is pre-dispersed containing powder substance, prevent its reunion, dispersing agent can be played the role of；In addition, the use of polyalcohol can also have Effect reduces bath foam system freezing point, makes hoof bath foam that stabilization be kept not freeze at low ambient temperatures, conducive to the use and storage of hoof bath foam. In addition to this, the glutaraldehyde in the polyalcohol and ingredient in system is used cooperatively, and stability of the glutaraldehyde in hoof bath foam can be improved；
（3）In addition, the nano silver monomer in component of the present invention has spectrum antibacterial effect, sterilizing ability is strong, in hoof bath foam It is used in compounding in system with glutaraldehyde and quaternary ammonium salt, its bactericidal effect can be enhanced, play synergistic effect.The present invention prepares gained bubble Foam hoof bath foam foam exquisiteness stabilization can persistently be kept, and highly-safe, easy to use, permeability is strong, and system is steady under cryogenic It is fixed not-easy-to-freeze, it is easy to store.
Figure of description
Foam form figure of the preparation gained environment-friendly composite foam hoof bath foam of Fig. 1 embodiment 1 after 10 times of foaming；
Fig. 2 milk cow carries out state diagram when hoof bath；
Original state figure after the bath of Fig. 3 sufferer milk cow hoof hoof；
Fig. 4 sufferer milk cow hoof figure；
State diagram after the bath of Fig. 5 sufferer milk cow hoof hoof 7 days.
Specific embodiment
Below by specific embodiment, technical solution of the present invention is further illustrated.
Embodiment 1
A kind of environment-friendly composite foam hoof bath foam, it is characterised in that：The environment-friendly composite foam hoof bath foam is by following weight The group of part is grouped as：
1 part of glutaraldehyde
1 part of quaternary ammonium salt
0.1 part of nano silver simple substance
1 part of foaming agent
0.5 part of foam stabilizer
8 parts of polyalcohol
0.1 part of pigment
10 parts of deionized water
Wherein, the quaternary ammonium salt is that benzalkonium bromide and bi-quaternary ammonium salt press 1:1 ratio mixes；
Wherein, the foam stabilizer is that guar gum and methyl cellulose ether press 1:2 ratio mixes；
Wherein, the polyalcohol is that ethyl alcohol mixes in any proportion with hexylene glycol；
Wherein, the foaming agent is that Tea Saponin and alkyl polyglycoside press 1:1 ratio mixes；
Wherein, the pigment is brilliant blue；
A kind of preparation method of the environment-friendly composite foam hoof bath foam comprises the steps of：
（1）Weigh by weight glutaraldehyde, benzalkonium bromide and bi-quaternary ammonium salt, nano silver simple substance, Tea Saponin and alkyl polyglycoside and Guar gum and methyl cellulose ether are added in the mixing liquid of ethyl alcohol weighed by weight and hexylene glycol, stir 1min, shape At dispersion；
（2）Brilliant blue pigment and deionized water are weighed by weight, by brilliant blue pigment and step（1）Dispersions obtained system is prepared to be added Into deionized water, after stirring 30min, 1h is stood to get environment-friendly composite foam hoof bath foam；
Application method：Preparation gained environment-friendly composite foam hoof bath foam is diluted by 2% mass concentration, afterwards with dedicated hair Bubble machine foamed after i.e. can be used, hoof bath can be carried out, can also direct spraying in cow hoof patient part；
Preparation gained composite foam hoof bath foam can be detained the longer time at sufferer, between slowly penetrating animal hoof toe, directly It acts at sufferer, effectively killing germ；In addition, hoof bath foam keeps stabilization not freeze at low ambient temperatures, conducive to hoof bath foam Use and storage.
Embodiment 2
A kind of environment-friendly composite foam hoof bath foam, the environment-friendly composite foam hoof bath foam is grouped as by the group of following parts by weight：
20 parts of glutaraldehyde
20 parts of quaternary ammonium salt
0.3 part of nano silver simple substance
15 parts of foaming agent
5 parts of foam stabilizer
10 parts of polyalcohol
0.6 part of pigment
30 parts of deionized water
Wherein, the quaternary ammonium salt is that benzalkonium chloride and dodecyl trimethyl ammonium chloride press 1:3 ratio mixes；
Wherein, the foam stabilizer is that nonionic guar gum and ethoxyl methyl cellulose ether press 1:10 ratio mixes；
Wherein, the polyalcohol is that ethylene glycol mixes in any proportion with butanediol；
Wherein, the foaming agent is that saponin and dodecyldimethyl ammonium oxide press 1:5 ratio mixes；
Wherein, the pigment is sapphire blue；
A kind of preparation method of the environment-friendly composite foam hoof bath foam comprises the steps of：
（1）Weigh by weight glutaraldehyde, benzalkonium chloride and dodecyl trimethyl ammonium chloride, nano silver simple substance, saponin with Dodecyldimethyl ammonium oxide and nonionic guar gum and ethoxyl methyl cellulose ether are added to second weighed by weight In glycol and butanediol mixing liquid, 1min is stirred, forms dispersion；
（2）Sapphire blue pigment and deionized water are weighed by weight, by sapphire blue pigment and step（1）Prepare dispersions obtained system It is add to deionized water, after stirring 30min, stands 1h to get environment-friendly composite foam hoof bath foam；
Application method：Preparation gained environment-friendly composite foam hoof bath foam is diluted by 2% mass concentration, afterwards with dedicated hair Bubble machine foamed after i.e. can be used, hoof bath can be carried out, can also direct spraying in cow hoof patient part.
Embodiment 3
A kind of environment-friendly composite foam hoof bath foam, the environment-friendly composite foam hoof bath foam are grouped by the group of following parts by weight At：
10 parts of glutaraldehyde
10 parts of quaternary ammonium salt
0.2 part of nano silver simple substance
7 parts of foaming agent
3.5 parts of foam stabilizer
9 parts of polyalcohol
0.3 part of pigment
20 parts of deionized water
Wherein, the quaternary ammonium salt is polyquaternium；
Wherein, the foam stabilizer is that amphoteric ion guar gum and hydroxypropyl methyl cellulose ether press 1:6 ratio mixes；
Wherein, the polyalcohol is that propylene glycol mixes in any proportion with glycerine；
Wherein, the foaming agent is that fatty alcohol polyoxyethylene ether and fatty amide polyoxyethylene ether press 1:3 ratio mixes；
Wherein, the pigment gardenia blue and positive blue combination；
A kind of preparation method of the environment-friendly composite foam hoof bath foam comprises the steps of：
（1）Glutaraldehyde, polyquaternium, nano silver simple substance, fatty alcohol polyoxyethylene ether and fatty acid amide polyoxy are weighed by weight Vinethene and amphoteric ion guar gum and hydroxypropyl methyl cellulose ether, are added to propylene glycol weighed by weight and glycerine In mixing liquid, 1min is stirred, forms dispersion；
（2）Gardenia blue and positive cyanine and deionized water are weighed by weight, by gardenia blue and positive cyanine and step（1）Preparation Dispersions obtained system is add to deionized water, and after stirring 30min, stands 1h to get environment-friendly composite foam hoof bath foam；
Application method：Preparation gained environment-friendly composite foam hoof bath foam is diluted by 2% mass concentration, afterwards with dedicated hair Bubble machine foamed after i.e. can be used, hoof bath can be carried out, can also direct spraying in cow hoof patient part.
Comparative test
（1）Foam hoof bath foam freezing point comparative test
Experiment 1：The preparation gained environment-friendly composite foam hoof bath foam of embodiment 1；
Experiment 2：The preparation gained environment-friendly composite foam hoof bath foam of embodiment 2；
Experiment 3：The preparation gained environment-friendly composite foam hoof bath foam of embodiment 3；
Experiment 4：It prepares without ethyl alcohol and hexylene glycol component in hoof bath compositions, remaining component and its preparation technology parameter are the same as implementation Example 1, preparation gained environment-friendly composite foam hoof bath foam；
Experiment 5：It prepares without ethylene glycol and butanediol component in hoof bath compositions, remaining component and its preparation technology parameter are the same as real Apply example 2, preparation gained environment-friendly composite foam hoof bath foam；
Experiment 6：It prepares without propylene glycol and glycerol fractions in hoof bath compositions, remaining component and its preparation technology parameter are the same as real Apply example 3, preparation gained environment-friendly composite foam hoof bath foam；
The freezing point of 1 ~ 6 preparation gained foam hoof bath foam of experiment is tested, test method：By the refractive prism of freezing point tester It is directed at bright direction, eyepiece diopter ring is adjusted and tester is calibrated until graticule is clear, make in eyepiece field of view The line of demarcation Lan Bai is overlapped with reference line.It takes 3 drop samples drop to press lightly on refractive prism, covering cover board when test, reads The corresponding scale in the line of demarcation Lan Bai is measurement result out.The results are shown in Table 1：
By above-mentioned test result it is found that 1 ~ 3 preparation gained hoof bath foam freezing point of experiment is lower, minimum reachable -13 DEG C, in contrast, Polyol component is not contained in experiment 4 ~ 6, freezing point is higher, and under the conditions of being lower than -1 DEG C, hoof bath foam starts to freeze, and system is unstable It is fixed.Thus, it can be known that the polyol component that the present invention is added when preparing foam hoof bath foam can reduce system freezing point, make it lower It can still be kept under the conditions of temperature stable；
（2）The foam stability comparative test of foam hoof bath foam
Experiment 1：The preparation gained environment-friendly composite foam hoof bath foam of embodiment 1；
Experiment 2：The preparation gained environment-friendly composite foam hoof bath foam of embodiment 2；
Experiment 3：The preparation gained environment-friendly composite foam hoof bath foam of embodiment 3；
Experiment 4：Guar gum in embodiment 1 is replaced with into polyacrylamide with methyl cellulose ether, remaining component and its preparation Method parameter is the same as embodiment 1, preparation gained foam hoof bath foam；
Experiment 5：Nonionic guar gum in embodiment 2 is replaced with into polyvinyl alcohol with ethoxyl methyl cellulose ether, remaining group Point and preparation method thereof parameter with embodiment 2 prepare gained foam hoof bath foam；
Experiment 6：Amphoteric ion guar gum in embodiment 3 is replaced with into polyethylene glycol oxide with hydroxypropyl methyl cellulose ether, Remaining component and preparation method thereof parameter prepares gained foam hoof bath foam with embodiment 3；
Laboratory apparatus：Stopwatch, electronic balance, high speed agitator, graduated cylinder（mL）, beaker, dropper and it is other needed for reagent；
Experimental method：At room temperature, sample 5g is taken into beaker, is diluted to 100g, is stirred 1 minute with high speed agitator, Foam is poured into graduated cylinder rapidly, observation is stood, records the initial volume of foam, with the half-life period of stopwatch record foam.With Foaming volume when 100g solution high-speed stirred 1min measures the foam performance of foaming agent, measures the steady of foam with half foam life period It is qualitative.Experimental result is as shown in table 2：
From the data in table 2, it can be seen that experiment 1 ~ 3 preparation gained hoof bath foam foam volume and half foam life period relatively experiment 4 ~ 6 have compared with It is big to improve, wherein the longer i.e. durable lather of the hoof bath foam half foam life period of experiment 2 is stablized, and test 3 hoof bath foam foam volume Larger, that is, testing 3 samples can produce better bubble effect;
The foam stabilizer that experiment 4 ~ 6 takes is respectively polyacrylamide, polyvinyl alcohol, polyethylene glycol oxide, and such foam stabilizer viscosity is larger, Main to make the reduction of liquid film drain age velocity by liquid phase viscosity in increase system, the atmosphere exchange rate between bubble also reduces, increases Glutinous amplitude is larger, can reduce the foaming volume of foam system, foam stabilizing effect is poor；The foam stabilizer selected in experiment 1 ~ 3 can not only Increase liquid phase viscosity, while there are also important features in structure, can be significantly hotter than the toughness, compressibility and service life of bubble general Water flowing film is formed by foam;
（3）The measurement of foam hoof bath foam adhesive ability
Experiment sample：
Sample 1：The preparation gained foam hoof bath foam of embodiment 1；
Sample 2：Guar gum in embodiment 1 is replaced with into polyacrylamide with methyl cellulose ether, remaining component and its preparation Method parameter is the same as embodiment 1, preparation gained foam hoof bath foam；
Selection pasture is experimental subjects, and surveying local surface temperature is 32 DEG C.It sets the foam hoof bath foam of sample 1 and 2 is foamed It is standby to carry out 10 volume foaming, make foam full of milk cow hoof bathing pool.Arbitrarily choosing 100 cow head of pasture is subjects, at random It is divided into 2 groups, every group is 50, this two groups of milk cows is made to pass by respectively the hoof bathing pool equipped with experiment sample 1 and 2, observation and record bubble Adhesiving effect and foam retention time of the foam on cow hoof.Experimental result is as shown in table 3：
From the data in table 3, it can be seen that the embodiment of the present invention 1 preparation gained foam hoof bath foam residence time on milk cow hoof it is longer, i.e., its Adhesive ability is preferable.
Example
For the clinical efficacy for proving present invention gained environment-friendly type foam hoof bath foam, 510 are selected in five pastures of the Northwest Milk cow hoof disease, wherein wart dermatitis 150, hyperplasia 105 between toe, hoof bottom ulcer 105, foot rot 75, other types hoof Disease 75；This 510 milk cow is randomly divided into 3 groups of A, B, C, every group of 170 cow heads；
Case selection standard：There is obvious limping symptom, likes to lie prone sleeping, dysstasia or stand up time are shorter；Suffering limb weight bearing it is not firm or Each limb hoof alternately bears a heavy burden；Palpation suffering limb hoof temperature increases, pain sensitivity when percussion.Infected cattle shows spiritual depressed, loss of appetite, milk production Amount decline, body temperature increases sometimes, sometimes up to 40 DEG C or more.Such as aggravation, individual illness milk cows show some whole body diseases Shape, severe one affected part is red and swollen, and sleeping ground does not rise；
Thoroughly cleaning cow hoof portion, it is ensured that hoof and interdigit do not have excrement residual, are allowed to clean；
Experimental group：The preparation gained foam hoof bath foam of embodiment 2 is selected, the bath foam that mass concentration is 5% is formulated as, with foaming Equipment foams, and makes foam full of bathing pool；
Control group 1：Selecting mass concentration is 5% CuSO4Mass concentration is 5%CuSO by solution4Solution directly pours into hoof bathing pool In；
Control group 2：Nonionic guar gum in embodiment 2 is replaced with into polyvinyl alcohol with ethoxyl methyl cellulose ether, is free of Polyalcohol is replaced with CuSO by nano silver simple substance4Solution, remaining component and preparation method thereof parameter prepare gained with embodiment 2 Foam hoof bath foam is formulated as the bath foam that mass concentration is 5%, is foamed with foaming machine, makes foam full of bathing pool；
Experimental method：Tri- groups of group A, B, C of milk cow hoof is controlled respectively with the bath foam of experimental group, control group 1 and control group 2 It treats, once in the morning and once at night, continues hoof and bathe 16 days, 4 days are a cycle, are observed and recorded；The 7th day after hoof bath, the disease of observation in 14 days Ox symptom；
Curative effect determinate standard：Sufferer milk cow, which walks lamely, to disappear, and pain disappears, and swelling is subsided, and wound healing is to cure；Pain obviously subtracts Gently, swelling range shorter, walk lamely mitigate or it is unobvious be effective；Pain does not disappear, and swelling walks lamely without recession without recession, there is fortune Dynamic obstacle is invalid；
Experimental result is as shown in table 4,5：
By experimental data in table 4 and 5 it is found that present invention gained foam hoof bath foam can effectively cure Milk cow hoof disease, to wart skin, toe Between hyperplasia, hoof bottom ulcer, foot rot and other types hoof disease have preferable therapeutic effect and higher cure rate.Reason exists Association is produced between the polyalcohol, foam stabilizer and nano silver monomer and other components for preparing the addition of foam hoof bath foam in the present invention Same-action enhances the drug effect of bath foam;
Fig. 4 is illness milk cow hoof, and Fig. 5 is milk cow hoof instance graph after experimental group hoof is bathed 7 days, compares Figure 4 and 5 it will be evident that ox Hoof disease trouble is obviously improved, and hair color restores normal.

Claims (4)

1. a kind of environment-friendly composite foam hoof bath foam, it is characterised in that：The environment-friendly composite foam hoof bath foam is by following heavy The group of amount part is grouped as：
1 ~ 20 part of glutaraldehyde
1 ~ 20 part of quaternary ammonium salt
0.1 ~ 0.3 part of nano silver simple substance
1 ~ 15 part of foaming agent
0.5 ~ 5 part of foam stabilizer
8 ~ 10 parts of polyalcohol
0.1 ~ 0.6 part of pigment
10 ~ 30 parts of deionized water
Wherein, the quaternary ammonium salt is benzalkonium bromide, benzalkonium chloride, dodecyl trimethyl ammonium chloride, polyquaternium or double quaternary ammoniums Any one of salt or by wherein any two kinds press 1:1~1:3 ratio mixes；
Wherein, the foam stabilizer is guar gum and its derivative nonionic guar gum, cation guar gum, amphoteric ion Guar Glue, methyl cellulose ether and its derivative ethoxyl methyl cellulose ether, hydroxypropyl methyl cellulose ether, ethylmethylcellulose Ether, carboxy methyl cellulose ether, any one of cellulose ether, polyethylene glycol stearate or by wherein any two Kind presses 1:2~1:10 ratio mixes；
Wherein, the polyalcohol be ethyl alcohol, it is ethylene glycol, propylene glycol, glycerine, butanediol, any in hexylene glycol or by it In any two kinds mix in any proportion.
2. environment-friendly composite foam hoof bath foam according to claim 1, it is characterised in that：The foaming agent is Tea Saponin, soap Angle glycosides, fatty alcohol polyoxyethylene ether, ethoxylated dodecyl alcohol, fatty amide polyoxyethylene ether, fatty acid distribution of coconut oil diethanol acyl Amine, cocoamidopropyl dimethyl glycine betaine, cocamidopropyl propyl amide hydroxyl sulphonic acid betaine, dodecyldimethyl ammonium oxide, alkane Any one of alkyl polyglucosides or by wherein any two kinds press 1:1~1:5 ratio mixes.
3. environment-friendly composite foam hoof bath foam according to claim 2, it is characterised in that：The pigment is brilliant blue, acid blue, treasured Shi Lan, gardenia blue, it is positive blue, indigo in any group or combinations thereof.
4. a kind of such as any one of the claim 1 ~ 3 environment-friendly composite foam hoof bath foam, it is characterised in that：The environmental protection is compound The preparation method of type foam hoof bath foam comprises the steps of：
（1）Glutaraldehyde, quaternary ammonium salt, nano silver simple substance, foaming agent and foam stabilizer are weighed by weight, are added to and are weighed by weight Polyol liquid in, stir 1min, formed dispersion；
（2）Pigment and deionized water are weighed by weight, by pigment and step（1）It prepares dispersions obtained system and is added to deionization In water, after stirring 30min, 1h is stood to get environment-friendly composite foam hoof bath foam.
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CN109481395A (en) * 2018-12-24 2019-03-19 刘长德 A kind of foam filling paste and application for preventing and treating domestic animal hoof disease
CN110079402A (en) * 2019-05-30 2019-08-02 陕西汉隆清洁消毒产品有限公司 Compound alkaline foam cleaning agent of a kind of environment-friendly type and preparation method thereof
CN110507748A (en) * 2019-09-09 2019-11-29 郑州百瑞动物药业有限公司 A kind of milk cow hoof bath foam and preparation method thereof
CN115737611A (en) * 2022-12-01 2023-03-07 成都科宏达科技有限公司 Low-temperature stable animal medicated bath lotion
CN115737611B (en) * 2022-12-01 2024-05-14 成都科宏达科技有限公司 Animal medicated bath lotion with low temperature stability

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109481395A (en) * 2018-12-24 2019-03-19 刘长德 A kind of foam filling paste and application for preventing and treating domestic animal hoof disease
CN110079402A (en) * 2019-05-30 2019-08-02 陕西汉隆清洁消毒产品有限公司 Compound alkaline foam cleaning agent of a kind of environment-friendly type and preparation method thereof
CN110079402B (en) * 2019-05-30 2021-03-19 陕西汉隆清洁消毒产品有限公司 Environment-friendly composite alkaline foam cleaning agent and preparation method thereof
CN110507748A (en) * 2019-09-09 2019-11-29 郑州百瑞动物药业有限公司 A kind of milk cow hoof bath foam and preparation method thereof
CN115737611A (en) * 2022-12-01 2023-03-07 成都科宏达科技有限公司 Low-temperature stable animal medicated bath lotion
CN115737611B (en) * 2022-12-01 2024-05-14 成都科宏达科技有限公司 Animal medicated bath lotion with low temperature stability

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