CN108815214A - 用于治疗肝癌的药物及应用 - Google Patents
用于治疗肝癌的药物及应用 Download PDFInfo
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- CN108815214A CN108815214A CN201811051143.XA CN201811051143A CN108815214A CN 108815214 A CN108815214 A CN 108815214A CN 201811051143 A CN201811051143 A CN 201811051143A CN 108815214 A CN108815214 A CN 108815214A
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种用于治疗肝癌的药物,包括大驳骨提取物,所述大驳骨提取物的制备包括以下步骤:S1、将大驳骨置于沸水中提取,得到水提液;S2、将S1中的水提液分离提纯后即得大驳骨提取物。本发明的用于治疗肝癌的药物,包括大驳骨提取物,实验表明大驳骨提取物对BEL‑7402、Hep‑B3肝癌细胞株的生长具有显著抑制作用。
Description
技术领域
本发明涉及医药技术领域。更具体地说,本发明涉及一种用于治疗肝癌的药物及应用。
背景技术
原发性肝癌是我国常见恶性肿瘤之一。死亡率高,在恶性肿瘤死亡顺位中仅次于胃、食道而居第三位,在部份地区的农村中占第二位,仅次于胃癌。我国每年死于肝癌约11万人,占全世界肝癌死亡人数的45%。因此,加强原发性肝癌治疗的研究,延长患者生存期,提高疗效,改善患者生活质量是临床肿瘤工作者的当务之急。肝癌主要治疗手段为手术切除,早期术后1年、3年及5年生存率分别为80~92%、61~86%和41~75%。但90%患者因肿瘤较大或肝硬化而失去手术机会;正常肝脏细胞对放射线敏感,而肝癌细胞则敏感性较差,需>4000cGy才可能得到一定的局部控制;局部消融疗法能起到局部控制肿瘤、缓解症状等作用,可作为不能接受手术切除患者的治疗选择,但仅对肿瘤小于5cm的肝癌有效;化疗药物对肝癌的部分缓解率均在20%以下,疗效不理想;经肝动脉导管化疗栓塞(TACE)或TACE加门静脉栓塞(PVE)使有效率有一定提高,生存期也有改善,但在动脉栓塞是否完全、最佳的药物联合及最佳的栓塞机型等方面仍需进一步研究;生物靶向治疗对原发性肝癌的有效率均低于10%。综上所述,现代医学对中晚期原发性肝癌仍无良好的治疗方法。中医药治疗中晚期原发性肝癌有潜在优势,如何开发出安全高效的中医药,具有非常重要的意义。
发明内容
本发明的一个目的是解决至少上述问题,并提供至少后面将说明的优点。
本发明的另一个目的是提供一种用于治疗肝癌的药物,包括大驳骨提取物,实验表明大驳骨提取物对BEL-7402、Hep-B3肝癌细胞株的生长具有显著抑制作用。
为了实现本发明的这些目的和其它优点,提供了一种用于治疗肝癌的药物,包括大驳骨提取物,所述大驳骨提取物的制备包括以下步骤:
S1、将大驳骨置于沸水中提取,得到水提液;
S2、将S1中的水提液分离提纯后即得大驳骨提取物。
优选的是,所述的用于治疗肝癌的药物,S1中使用沸水提取2次,每次2~3h,合并2次的提取液即得水提液;S2中水提液分离提纯具体包括:将水提液在80℃的温度下浓缩至比重为1.05,然后采用D101大孔树脂洗脱,洗脱剂依次为体积分数为20%、50%、95%的乙醇,收集95%的乙醇洗脱液,除去乙醇,浓缩至比重为1.08,即得大驳骨提取物。
优选的是,所述的用于治疗肝癌的药物,还包括中药提取物,所述中药提取物的制备方法包括以下步骤:
A1、将重量份2~5份的猪苓、3~6份的蒲公英、2~6份的山豆根、1~3份的八月扎、3~6份的垂盆草、2~5份的虎杖、1~3份的马蔺、2~5份的长春花、1~4份的甘草、2~5份的龙胆草、2~6份的绞股蓝、1~3份的冬凌草、5~8份的七叶一枝花、2~6份的紫草、3~6份的白英、3~6份的蛇莓、2~5份的猪殃殃、3~6份的断肠草、1~3份的墓头回、2~4份的草珊瑚、2~5份的半边莲、4~7份的天花粉、2~5份的夏枯草、3~8份的黄药子、2~5份的莪术、1~3份的王不留行、2~6份的铁树叶、3~6份的泽漆、2~6份的白术混合粉碎后得到第一混料;将重量份为3~5份的纤维素酶、2~6份的蛋白酶、1~3份的果胶酶与重量份为10~15份的水混合后得到水酶液,将水酶液喷淋在第一混合物中搅拌均匀后,并于35℃下静置15~20min,得到第二混料;将第二混合物置于密闭容器中,然后向密闭容器中通入饱和水蒸气以使密闭容器中的压力为1.1Mpa,维持20~30min后,然后于4~6s内使密闭容器中压力降低至5~10pa,保持3~6min后,取出得到第三混料;然后向第三混料中加入重量份为150~160份的水,于温度为90~95℃下煎煮2~3h,过滤,得到滤液,将滤液真空浓缩干燥后得到第一粉末;
A2、将重量份为2~5份的壁虎、3~5份的水蛭粉碎后,置于重量份为15~20份的浸泡液中浸泡30~40min后过滤得到第四混料,所述浸泡液的制备方法为:将番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮溶于温度为80~90℃的水中浸泡1~2h,过滤即得浸泡液;其中,浸泡液中番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮、水的质量比为3~5:0.5~1:0.8~1.2:1~1.5:0.5~1:0.5~1:50~60;
A3、将A2中得到的第四混料加入重量份为80~90份的水中,加热回流3~4h,过滤,得到第一滤液和第一滤渣,备用;然后,将第一滤渣置于体积分数为85~90%的乙醇溶液中浸泡5~10h,过滤,得到第二滤液,将第一滤液、第二滤液混合后真空冷冻干燥后得到第二粉末;
A4、将第一粉末、第二粉末混合即得中药提取物;
所述大驳骨提取物与中药提取物的质量比为1:0.2。
优选的是,所述的用于治疗肝癌的药物,A3中真空冷冻干燥具体为:于-30~-25℃下冷冻2~3h,然后于真空度为5~10Pa、温度为60℃下干燥20~30h。
优选的是,所述的用于治疗肝癌的药物,A3中第四混料置于水中回流前,使用功率为300~500W的紫外灯照射5~10min。
本发明还提供了一种用于治疗肝癌的药物作为制备治疗肝癌的药物中的应用。
本发明至少包括以下有益效果:
1、本发明的用于治疗肝癌的药物,包括大驳骨提取物,实验表明大驳骨提取物对BEL-7402、Hep-B3肝癌细胞株的生长具有显著抑制作用。
2、本发明的用于治疗肝癌的药物,还包括中药提取物,中药提取物中猪苓等多种植物中草药同时还包括壁虎、水蛭药物动物,动物、植物之间能够产生协同增效作用不仅可以进一步提高对BEL-7402、Hep-B3肝癌细胞株生长的抑制作用,同时研究表明中药提取物的加入还具有抗腮腺炎的作用,实验表明其对小鼠的肿胀抑制率可高达85.9%。
3、本发明的用于治疗肝癌的药物,在制备第一粉末过程中,首选通过纤维素酶、蛋白酶、果胶酶将各种中草药酶解后,这使得中草药的细胞壁遭到破坏,然后再将酶解后的中草药置于密闭容器中,首先通入高压水蒸气,然后瞬间泄压,在通入高压水蒸气的过程中,高压水蒸气经过破坏的细胞壁后渗透至中草药内部,然后瞬间泄压,在此过程中,渗透至中草药内部的高压水蒸气会从中草药内部“喷出”,以致达到***的出效果,这样使得中草药从内部炸裂,中草药中的有效药用成分可被高压水蒸气溶解出来,这相比传统的提取方法很明显提取率大大提高。
4、本发明的用于治疗肝癌的药物,将壁虎、水蛭粉碎后使用浸泡液浸泡,由于壁虎、水蛭为动物,难免会有腥味,通过浸泡液浸泡后可以除去壁虎、水蛭的腥味,浸泡液中番茄含有柠檬酸、苹果酸等有机酸具有中和去腥的作用,浸泡液中虎尾兰、常春藤、艾草、柠檬草、桂皮以自身的气味掩盖动物的腥味。
本发明的其它优点、目标和特征将部分通过下面的说明体现,部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
下面对本发明做进一步的详细说明,以令本领域技术人员参照说明书文字能够据以实施。需要说明的是,下述实施方案中所述实验方法,如无特殊说明,均为常规方法,所述试剂和材料,如无特殊说明,均可从商业途径获得。
实施例1
一种用于治疗肝癌的药物,包括大驳骨提取物,所述大驳骨提取物的制备包括以下步骤:
S1、将大驳骨置于沸水中提取,得到水提液;
S2、将S1中的水提液分离提纯后即得大驳骨提取物。
所述的用于治疗肝癌的药物,S1中使用沸水提取2次,每次2h,合并2次的提取液即得水提液;S2中水提液分离提纯具体包括:将水提液在80℃的温度下浓缩至比重为1.05,然后采用D101大孔树脂洗脱,洗脱剂依次为体积分数为20%、50%、95%的乙醇,收集95%的乙醇洗脱液,除去乙醇,浓缩至比重为1.08,即得大驳骨提取物。
实施例2
一种用于治疗肝癌的药物,包括大驳骨提取物,所述大驳骨提取物的制备包括以下步骤:
S1、将大驳骨置于沸水中提取,得到水提液;
S2、将S1中的水提液分离提纯后即得大驳骨提取物。
所述的用于治疗肝癌的药物,S1中使用沸水提取2次,每次2h,合并2次的提取液即得水提液;S2中水提液分离提纯具体包括:将水提液在80℃的温度下浓缩至比重为1.05,然后采用D101大孔树脂洗脱,洗脱剂依次为体积分数为20%、50%、95%的乙醇,收集95%的乙醇洗脱液,除去乙醇,浓缩至比重为1.08,即得大驳骨提取物。
所述的用于治疗肝癌的药物,还包括中药提取物,所述中药提取物的制备方法包括以下步骤:
A1、将重量份2份的猪苓、3份的蒲公英、2份的山豆根、1份的八月扎、3份的垂盆草、2份的虎杖、1份的马蔺、2份的长春花、1份的甘草、2份的龙胆草、2份的绞股蓝、1份的冬凌草、5份的七叶一枝花、2份的紫草、3份的白英、3份的蛇莓、2份的猪殃殃、3份的断肠草、1份的墓头回、2份的草珊瑚、2份的半边莲、4份的天花粉、2份的夏枯草、3份的黄药子、2份的莪术、1份的王不留行、2份的铁树叶、3份的泽漆、2份的白术混合粉碎后得到第一混料;将重量份为3份的纤维素酶、2份的蛋白酶、1份的果胶酶与重量份为10份的水混合后得到水酶液,将水酶液喷淋在第一混合物中搅拌均匀后,并于35℃下静置15min,得到第二混料;将第二混合物置于密闭容器中,然后向密闭容器中通入饱和水蒸气以使密闭容器中的压力为1.1Mpa,维持20min后,然后于4s内使密闭容器中压力降低至5pa,保持3min后,取出得到第三混料;然后向第三混料中加入重量份为150份的水,于温度为90℃下煎煮2h,过滤,得到滤液,将滤液真空浓缩干燥后得到第一粉末;
A2、将重量份为2份的壁虎、3份的水蛭粉碎后,置于重量份为15份的浸泡液中浸泡30min后过滤得到第四混料,所述浸泡液的制备方法为:将番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮溶于温度为80℃的水中浸泡1h,过滤即得浸泡液;其中,浸泡液中番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮、水的质量比为3:0.5:0.8:1:0.5:0.5:50;
A3、将A2中得到的第四混料加入重量份为80份的水中,加热回流3h,过滤,得到第一滤液和第一滤渣,备用;然后,将第一滤渣置于体积分数为85%的乙醇溶液中浸泡5h,过滤,得到第二滤液,将第一滤液、第二滤液混合后真空冷冻干燥后得到第二粉末;
A4、将第一粉末、第二粉末混合即得中药提取物;
所述大驳骨提取物与中药提取物的质量比为1:0.2。
所述的用于治疗肝癌的药物的制备方法,A3中真空冷冻干燥具体为:于-30℃下冷冻2h,然后于真空度为5Pa、温度为60℃下干燥20h。
所述的用于治疗肝癌的药物的制备方法,A3中第四混料置于水中回流前,使用功率为300W的紫外灯照射5min。
实施例3
一种用于治疗肝癌的药物,包括大驳骨提取物,所述大驳骨提取物的制备包括以下步骤:
S1、将大驳骨置于沸水中提取,得到水提液;
S2、将S1中的水提液分离提纯后即得大驳骨提取物。
所述的用于治疗肝癌的药物,S1中使用沸水提取2次,每次2h,合并2次的提取液即得水提液;S2中水提液分离提纯具体包括:将水提液在80℃的温度下浓缩至比重为1.05,然后采用D101大孔树脂洗脱,洗脱剂依次为体积分数为20%、50%、95%的乙醇,收集95%的乙醇洗脱液,除去乙醇,浓缩至比重为1.08,即得大驳骨提取物。
所述的用于治疗肝癌的药物,还包括中药提取物,所述中药提取物的制备方法包括以下步骤:
A1、将重量份3份的猪苓、5份的蒲公英、4份的山豆根、2份的八月扎、5份的垂盆草、3份的虎杖、2份的马蔺、3份的长春花、2份的甘草、3份的龙胆草、4份的绞股蓝、2份的冬凌草、6份的七叶一枝花、4份的紫草、4份的白英、5份的蛇莓、3份的猪殃殃、4份的断肠草、2份的墓头回、3份的草珊瑚、3份的半边莲、5份的天花粉、3份的夏枯草、5份的黄药子、3份的莪术、2份的王不留行、4份的铁树叶、5份的泽漆、4份的白术混合粉碎后得到第一混料;将重量份为4份的纤维素酶、4份的蛋白酶、2份的果胶酶与重量份为12份的水混合后得到水酶液,将水酶液喷淋在第一混合物中搅拌均匀后,并于35℃下静置18min,得到第二混料;将第二混合物置于密闭容器中,然后向密闭容器中通入饱和水蒸气以使密闭容器中的压力为1.1Mpa,维持25min后,然后于5s内使密闭容器中压力降低至8pa,保持4min后,取出得到第三混料;然后向第三混料中加入重量份为155份的水,于温度为93℃下煎煮3h,过滤,得到滤液,将滤液真空浓缩干燥后得到第一粉末;
A2、将重量份为3份的壁虎、4份的水蛭粉碎后,置于重量份为18份的浸泡液中浸泡35min后过滤得到第四混料,所述浸泡液的制备方法为:将番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮溶于温度为85℃的水中浸泡1h,过滤即得浸泡液;其中,浸泡液中番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮、水的质量比为4:0.8:1:1.2:0.8:0.8:55;
A3、将A2中得到的第四混料加入重量份为85份的水中,加热回流4h,过滤,得到第一滤液和第一滤渣,备用;然后,将第一滤渣置于体积分数为88%的乙醇溶液中浸泡8h,过滤,得到第二滤液,将第一滤液、第二滤液混合后真空冷冻干燥后得到第二粉末;
A4、将第一粉末、第二粉末混合即得中药提取物;
所述大驳骨提取物与中药提取物的质量比为1:0.2。
所述的用于治疗肝癌的药物,A3中真空冷冻干燥具体为:于-28℃下冷冻3h,然后于真空度为8Pa、温度为60℃下干燥25h。
所述的用于治疗肝癌的药物,A3中第四混料置于水中回流前,使用功率为400W的紫外灯照射8min。
实施例4
一种用于治疗肝癌的药物,包括大驳骨提取物,所述大驳骨提取物的制备包括以下步骤:
S1、将大驳骨置于沸水中提取,得到水提液;
S2、将S1中的水提液分离提纯后即得大驳骨提取物。
所述的用于治疗肝癌的药物,S1中使用沸水提取2次,每次2h,合并2次的提取液即得水提液;S2中水提液分离提纯具体包括:将水提液在80℃的温度下浓缩至比重为1.05,然后采用D101大孔树脂洗脱,洗脱剂依次为体积分数为20%、50%、95%的乙醇,收集95%的乙醇洗脱液,除去乙醇,浓缩至比重为1.08,即得大驳骨提取物。
所述的用于治疗肝癌的药物,还包括中药提取物,所述中药提取物的制备方法包括以下步骤:
A1、将重量份5份的猪苓、6份的蒲公英、6份的山豆根、3份的八月扎、6份的垂盆草、5份的虎杖、3份的马蔺、5份的长春花、4份的甘草、5份的龙胆草、6份的绞股蓝、3份的冬凌草、8份的七叶一枝花、6份的紫草、6份的白英、6份的蛇莓、5份的猪殃殃、6份的断肠草、3份的墓头回、4份的草珊瑚、5份的半边莲、7份的天花粉、5份的夏枯草、8份的黄药子、5份的莪术、3份的王不留行、6份的铁树叶、6份的泽漆、6份的白术混合粉碎后得到第一混料;将重量份为5份的纤维素酶、6份的蛋白酶、3份的果胶酶与重量份为5份的水混合后得到水酶液,将水酶液喷淋在第一混合物中搅拌均匀后,并于35℃下静置20min,得到第二混料;将第二混合物置于密闭容器中,然后向密闭容器中通入饱和水蒸气以使密闭容器中的压力为1.1Mpa,维持30min后,然后于6s内使密闭容器中压力降低至10pa,保持6min后,取出得到第三混料;然后向第三混料中加入重量份为160份的水,于温度为95℃下煎煮3h,过滤,得到滤液,将滤液真空浓缩干燥后得到第一粉末;
A2、将重量份为5份的壁虎、5份的水蛭粉碎后,置于重量份为20份的浸泡液中浸泡40min后过滤得到第四混料,所述浸泡液的制备方法为:将番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮溶于温度为90℃的水中浸泡2h,过滤即得浸泡液;其中,浸泡液中番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮、水的质量比为5:1:1.2:1.5:1:1:60;
A3、将A2中得到的第四混料加入重量份为90份的水中,加热回流4h,过滤,得到第一滤液和第一滤渣,备用;然后,将第一滤渣置于体积分数为90%的乙醇溶液中浸泡10h,过滤,得到第二滤液,将第一滤液、第二滤液混合后真空冷冻干燥后得到第二粉末;
A4、将第一粉末、第二粉末混合即得中药提取物;
所述大驳骨提取物与中药提取物的质量比为1:0.2。
所述的用于治疗肝癌的药物,A3中真空冷冻干燥具体为:于-30℃下冷冻3h,然后于真空度为10Pa、温度为60℃下干燥30h。
所述的用于治疗肝癌的药物,A3中第四混料置于水中回流前,使用功率为500W的紫外灯照射10min。
对比例1
同实施例2,不同在于,中药提取物中不含有第二粉末。
抗肿瘤活性试验方法
体外抗肿瘤活性试验
1、细胞株及培养
将BEL-7402肝癌细胞株,培养于含12%灭活胎牛血清、90U/mL青霉素,90μg/mL链霉素的RPMn640培养基中,于37℃,5%CO2培养箱及饱和湿度条件下培养,3~4天传代一次。
将Hep-B3肝癌细胞株,培养于含12%灭活胎牛血清,90U/mL青霉素,90μg/mL链霉素的DMEM培养基中,于37℃,5%CO2培养箱及饱和湿度条件下培养,3~4天传代一次。
2、药物抗肿瘤活性测定
MTT法:将对数生长期细胞用胰酶消化后配制成浓度为3×104个/mL的细胞悬液,接种于96孔酶标板,每孔加200μL。24h后换不含血清培养液使细胞同步化生长,每孔200μL。然后向孔中加入受试药,即分别加入实施例1、实施例2、对比例1的药物;另设对照组:0.1%二甲基亚砜(DMSO)每孔加200μL。受试药每组分别设0.01、0.1、1、10、100、1000μg/mL六个浓度,每个浓度设8个平行孔,于37℃下培养24h后,每孔加无血清无酚红培养液新鲜配制的0.5mg/mL的MTT100μL,继续培养4h,然后,每孔加100μL的DMSO溶解MTT甲臜颗粒,用微型振荡器振荡混匀后,于酶标仪上测定光密度值(OD),实验重复三次,取平均值。以溶剂对照处理肿瘤细胞为对照组,由OD值计算抑制率,公式为:细胞生长抑制率=(对照组OD值-受试药组OD值)/对照组OD×100%,并以药物浓度为横坐标,OD值为纵坐标,绘制细胞生长曲线,并求得IC50(半数抑制率),IC50=细胞生长抑制率为50%的药物浓度,实验结果如表1所示。
表1-不同实施例的抗肿瘤活性实验结果
实施例 | BEL-7402IC50(μg/mL) | Hep-B3IC50(μg/mL) |
实施例1 | 38.42 | 35.63 |
实施例2 | 16.12 | 17.36 |
对比例1 | 21.89 | 22.52 |
从表1中可知本发明的治疗肝癌的药物,经体外MTT试验证明,此药物组合物可显著抑制BEL-7402、Hep-B3肝癌细胞株生长,且实施例2效果最好,说明实施例2中加入的中药提取物对癌细胞的抑制效果最好。
取小鼠120只,随机分为四组,一组为对照组,另外三组分别用吲哚美辛和本发明实施例2的治疗肝癌的药物以及对比例1的药物致炎前皮肤给药,每日一次,连续三天。于最后一次给药后半小时将二甲苯涂于小鼠右耳内外两面,每鼠约0.05ml,42Min后处死动物,用直径为6mm的打孔器沿左右耳廓相同部位打孔取材称重,以每组两耳片的重量差异为肿胀程度指标,比较给药组和对照组之间的差异,并求出抑肿率。肿胀抑制率=(对照组耳片重量差-给药组耳片重量差)/对照组耳片重量差×100%。实验结果如表2所示。
表2-不同实施例的药物对小鼠的耳肿胀的影响
实施例 | 两耳片重量差 | 抑制肿胀率(%) |
对照组 | 9.38 | - |
吲哚美辛组 | 1.79 | 80.9 |
实施例2药物组 | 1.32 | 85.9 |
对比例1药物组 | 1.68 | 82.1 |
从表2中可知本发明的实施例2的治疗肝癌的药物,还具有良好的抗腮腺炎的作用。且实施例2的抗腮腺炎的效果优于对比例1的药物。
尽管本发明的实施方案已公开如上,但其并不仅仅限于说明书和实施方式中所列运用,它完全可以被适用于各种适合本发明的领域,对于熟悉本领域的人员而言,可容易地实现另外的修改,因此在不背离权利要求及等同范围所限定的一般概念下,本发明并不限于特定的细节。
Claims (6)
1.用于治疗肝癌的药物,其特征在于,包括大驳骨提取物,所述大驳骨提取物的制备包括以下步骤:
S1、将大驳骨置于沸水中提取,得到水提液;
S2、将S1中的水提液分离提纯后即得大驳骨提取物。
2.如权利要求1所述的用于治疗肝癌的药物,其特征在于,S1中使用沸水提取2次,每次2~3h,合并2次的提取液即得水提液;S2中水提液分离提纯具体包括:将水提液在80℃的温度下浓缩至比重为1.05,然后采用D101大孔树脂洗脱,洗脱剂依次为体积分数为20%、50%、95%的乙醇,收集95%的乙醇洗脱液,除去乙醇,浓缩至比重为1.08,即得大驳骨提取物。
3.如权利要求1所述的用于治疗肝癌的药物,其特征在于,还包括中药提取物,所述中药提取物的制备方法包括以下步骤:
A1、将重量份2~5份的猪苓、3~6份的蒲公英、2~6份的山豆根、1~3份的八月扎、3~6份的垂盆草、2~5份的虎杖、1~3份的马蔺、2~5份的长春花、1~4份的甘草、2~5份的龙胆草、2~6份的绞股蓝、1~3份的冬凌草、5~8份的七叶一枝花、2~6份的紫草、3~6份的白英、3~6份的蛇莓、2~5份的猪殃殃、3~6份的断肠草、1~3份的墓头回、2~4份的草珊瑚、2~5份的半边莲、4~7份的天花粉、2~5份的夏枯草、3~8份的黄药子、2~5份的莪术、1~3份的王不留行、2~6份的铁树叶、3~6份的泽漆、2~6份的白术混合粉碎后得到第一混料;将重量份为3~5份的纤维素酶、2~6份的蛋白酶、1~3份的果胶酶与重量份为10~15份的水混合后得到水酶液,将水酶液喷淋在第一混合物中搅拌均匀后,并于35℃下静置15~20min,得到第二混料;将第二混合物置于密闭容器中,然后向密闭容器中通入饱和水蒸气以使密闭容器中的压力为1.1Mpa,维持20~30min后,然后于4~6s内使密闭容器中压力降低至5~10pa,保持3~6min后,取出得到第三混料;然后向第三混料中加入重量份为150~160份的水,于温度为90~95℃下煎煮2~3h,过滤,得到滤液,将滤液真空浓缩干燥后得到第一粉末;
A2、将重量份为2~5份的壁虎、3~5份的水蛭粉碎后,置于重量份为15~20份的浸泡液中浸泡30~40min后过滤得到第四混料,所述浸泡液的制备方法为:将番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮溶于温度为80~90℃的水中浸泡1~2h,过滤即得浸泡液;其中,浸泡液中番茄、虎尾兰、常春藤、艾草、柠檬草、桂皮、水的质量比为3~5:0.5~1:0.8~1.2:1~1.5:0.5~1:0.5~1:50~60;
A3、将A2中得到的第四混料加入重量份为80~90份的水中,加热回流3~4h,过滤,得到第一滤液和第一滤渣,备用;然后,将第一滤渣置于体积分数为85~90%的乙醇溶液中浸泡5~10h,过滤,得到第二滤液,将第一滤液、第二滤液混合后真空冷冻干燥后得到第二粉末;
A4、将第一粉末、第二粉末混合即得中药提取物;
所述大驳骨提取物与中药提取物的质量比为1:0.2。
4.如权利要求3所述的用于治疗肝癌的药物的制备方法,其特征在于,A3中真空冷冻干燥具体为:于-30~-25℃下冷冻2~3h,然后于真空度为5~10Pa、温度为60℃下干燥20~30h。
5.如权利要求3所述的用于治疗肝癌的药物的制备方法,其特征在于,A3中第四混料置于水中回流前,使用功率为300~500W的紫外灯照射5~10min。
6.如权利要求1~5任一所述的用于治疗肝癌的药物作为制备治疗肝癌的药物中的应用。
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