CN108743888A - It is a kind of to be used to prevent compound Chinese medicinal preparation of Duck Hepatitis Virus and preparation method thereof - Google Patents

It is a kind of to be used to prevent compound Chinese medicinal preparation of Duck Hepatitis Virus and preparation method thereof Download PDF

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CN108743888A
CN108743888A CN201811022068.4A CN201811022068A CN108743888A CN 108743888 A CN108743888 A CN 108743888A CN 201811022068 A CN201811022068 A CN 201811022068A CN 108743888 A CN108743888 A CN 108743888A
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parts
radix
preparation
chinese medicine
radix curcumae
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区炳庆
何永明
冼琼珍
赵海全
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Foshan University
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Foshan University
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Abstract

The present invention provides a kind of compound Chinese medicinal preparation for preventing Duck Hepatitis Virus, which is made of the material medicine of following parts by weight meter：20~30 parts of cordate houttuynia, 20~30 parts of Radix Astragali, 15~40 parts of Radix Glycyrrhizae, 10~20 parts of Schisandra chinensis, 10~20 parts of Fructus Forsythiae, 10~15 parts of oriental wormwood, 20~25 parts of giant knotweed, 10~15 parts of scutellaria, 10~15 points of Radix Curcumae, 20~25 parts of Radix Codonopsis, 10~15 parts of sealwort, 10~15 parts of radix scrophulariae.Heretofore described Chinese medicine preparation can be by effectively preventing Duck Hepatitis Virus, and the Chinese medicine preparation is powdered, it can be conveniently added in the feed of duckling, and preparation method of the present invention can largely retain medicinal ingredient and nutritional ingredient in Chinese medicine material, and production method is simply easy to spread.

Description

It is a kind of to be used to prevent compound Chinese medicinal preparation of Duck Hepatitis Virus and preparation method thereof
Technical field
The invention belongs to veterinary drug preparation fields, and in particular to it is a kind of for prevent Duck Hepatitis Virus Chinese medicine preparation and Preparation method.
Background technology
Duck virus hepatitis is a kind of Acute exposure sexually transmitted disease that duck hepatitis virus causes duckling.This disease has high contact Property, high lethal the characteristics of, have generation, and the four seasons the area such as the southwest in China, North China, Central China, East China, south China Outburst.This disease only infected duck, duckling susceptible disease, adult duck do not fall ill.In the season of duckling hatching, multiple prevalence, duckling morbidity Rate is up to duckling case fatality rate in 100%, 3 week old up to 50~95%.The visible duckling down in spirits of early stage, loss of appetite, Eye semi-closure is in comatose state, ash discharge white or green watery stools.There are nervous symptoms in subsequent duckling, and body is crooked, two leg convulsions Contraction stroke, opisthotonos are dead after a few hours.
Duck virus hepatitis is that duck hepatitis virus causes, and is I, II, III type of duck hepatitis virus (DHV) respectively, most common For I types of DHV, belong to enterovirus.20~40nm of size of virus, it is very strong to the resistance of external environment, in the chicken brooding house of pollution Interior virus can at least survive 10 weeks, and the virus in dark and damp place's excrement can survive 37 days.Excrement, crib, drinking-water can be passed through The propagation between duck is caused, pandemic is easily caused in breeding-ground compact district, causes huge economic loss.
It is directed to this disease at present to prevent to be more than treatment, preventing the disease, the most commonly used is vaccines and antibody.Vaccine is by adopting The internal organs of collection morbidity duck are screened suitable strain and are subject to adjuvant and be prepared by Virus Isolation, to prevent to be when use It is main.Since the development of vaccine often lags behind the infection of virus, in face of new variant viral, vaccine is usually without pre- preventive effect Fruit；Antibody is by vaccine to animal reinforced immunological, then acquires the serum of animal or produced ovum, passes through different production Technique extraction is prepared, promptly to put prevention first when use.Since the development of antibody has hysteresis quality as vaccine, because This, prevention and control to duck hepatitis also have limitation.
Clinically also usually Chinese medicine and antiviral Western medicine is used to prevent and treat duck hepatitis, such as Cortex Phellodendri, giant knotweed, fish Raw meat grass etc., which has duck hepatitis virus etc., to be significantly inhibited effect and has obtained clinical verification.But actually many situations Under, traditional Chinese medicine is since its prescription is unreasonable, and due effect cannot be played by frequently resulting in Chinese medicine, and clinical application effect is not good enough； Antiviral Western medicine such as Ribavirin, amantadine etc. is forbidden making by the Ministry of Agriculture at present due to there is drug resistance With.
Invention content
The present invention provides a kind of for preventing Chinese medicine preparation of Duck Hepatitis Virus and preparation method thereof, the Chinese medicine preparation Can be by effectively preventing Duck Hepatitis Virus, and the Chinese medicine preparation is powdered, can be conveniently added to duckling Feed in, and preparation method of the present invention can largely retain medicinal ingredient in Chinese medicine material and nutrition at Point, and production method is simply easy to spread.
A kind of compound Chinese medicinal preparation for preventing Duck Hepatitis Virus, which is by the original of following parts by weight meter Expect drug composition：20~30 parts of cordate houttuynia, 20~30 parts of Radix Astragali, 15~40 parts of Radix Glycyrrhizae, 10~20 parts of Schisandra chinensis, Fructus Forsythiae 10~20 Part, 10~15 parts of oriental wormwood, 20~25 parts of giant knotweed, 10~15 parts of scutellaria, 10~15 points of Radix Curcumae, 20~25 parts of Radix Codonopsis, sealwort 10~ 15 parts, 10~15 parts of radix scrophulariae.
Further, which is made of the material medicine of following parts by weight meter：25 parts of cordate houttuynia, 26 parts of Radix Astragali, 30 parts of Radix Glycyrrhizae, 12 parts of Schisandra chinensis, 15 parts of Fructus Forsythiae, 13 parts of oriental wormwood, 22 parts of giant knotweed, 11 parts of scutellaria, Radix Curcumae 12 divide, 23 parts of Radix Codonopsis, yellow Smart 12 parts, 12 parts of radix scrophulariae.
A kind of preparation method for preventing the compound Chinese medicinal preparation of Duck Hepatitis Virus includes the following steps：
(1) feedstock processing：According to carry out raw material proportioning described above, is cleaned proportioned, dried after segment It is spare；
(2) Radix Curcumae ethyl alcohol extracts：It is powder that Radix Curcumae, which is crushed, and ethyl alcohol then is added into Radix Curcumae powder, is 20 in temperature 1~2h is impregnated under conditions of~25 DEG C, then uses filter-cloth filtering, and filtered filtrate, which is concentrated in vacuo to no ethyl alcohol, to be flowed out Afterwards, concentrate is collected, Radix Curcumae concentrate is made；
(3) it decocts：To be mixed except the Chinese medicine material of Radix Curcumae, and thereto plus water, impregnated after being heated to 45 DEG C 30min~ Then 1h boils, filtered later to respectively obtain liquid and the dregs of a decoction, and boiling boiling is then continuously added into the dregs of a decoction, filtered The liquid that liquid is obtained by filtration with first is uniformly mixed, and is made and is decocted liquid；
(4) concentration extraction：It will decoct and be uniformly mixed with Radix Curcumae concentrate after liquid is cooled to room temperature, admixing medical solutions are made, Then under vacuum by admixing medical solutions, temperature is to carry out concentration extraction at 50~70 DEG C, and then alcohol precipitation extracts to obtain Chinese medicine Stoste；
(5) it dries：Chinese medicine stoste is dried, herb powder preparation is made.
Cordate houttuynia acrid flavour, it is cold, it is distributed in lung channel.It can sore be treated in clearing heat and detoxicating, detumescence, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach invigorating disappear Food is lung carbuncle, sore swollen toxin, hemorrhoidal hemorrhage, the retention of heat in the spleen and stomach etc. suffered from real heat, heat toxin, damp evil, disease heat is controlled.Cordate houttuynia has The effects that antibacterial, antiviral, raising immunity of organisms, diuresis.
Radix Astragali is warm-natured, sweet in flavor；Invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic；Radix Astragali has anti-oxidant and stable liver plasma membrane The effect of effect can promote bilirubin metabolism, reduce necrosis of liver cells, promote liver cell regeneration.
Radix Glycyrrhizae is sweet in flavor, mild-natured；It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription；Radix Glycyrrhizae can mitigate Degeneration of liver cells and necrosis reduce serum transaminase vigor, improve glycogen and DNA content in liver cell, promote liver cell again It is raw, there is inhibiting effect to hepatitis virus.
Schisandra chinensis is sour, sweet, warm-natured, restrains astringent method, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves；Active ingredient in Schisandra chinensis is to liver Dirty pathological lesion has mitigation effect, has facilitation to liver synthetic protein and glycogen generation, moreover it is possible to it is micro- to improve liver cell The content of mitochondrial cytochrome, to enhance the function of detoxification of liver.
It is Fructus Forsythiae bitter, cool in nature, there are affectionate removing toxic substances, dispersing swelling and dissipating binds effect；Fructus Forsythiae has protection liver, promotes liver cell regeneration, The liver cell of swelling is accelerated to subside, the balloon sample for reducing liver cell becomes and the fat drips of liver cell, promotes hepatic glycogen and ribonucleic acid The recovery of content, the effects that reducing the vigor of serum transaminase.
Oriental wormwood is bitterly, cold nature；Kind heat-clearing excreting dampness, normalizing gallbladder to cure jaundice, decoction, flooding agent, alcohol preserved material of oriental wormwood etc. have Promote choleresis, exclude bile, expansion bile duct, expansion Oddi formula sphincter, the systolic and diastolic function for adjusting pyloric sphincter, separately Outside, the capillarin in oriental wormwood can inhibit enteric bacteria to grow, and reduce murder by poisoning of its metabolite to stem cell, there is liver protection effect.
Giant knotweed acrid-sweet flavor slight bitter, cold nature, have clearing heat and detoxicating, normalizing gallbladder to cure jaundice, inducing diuresis for treating strangurtia, it is promoting blood circulation and removing blood stasis the effects that；Its Decoction, extract, injection have good result to acute icteric hepatitis.
Scutellaria bitter is cold in nature, has the functions such as clearing heat-fire, removing toxic substances tocolysis, the main component of scutellaria is scutellaria glycosides, to various Hepatitis has effect of reducing enzyme levels, and energy normalizing gallbladder to cure jaundice, and drop wadding will be turbid.
Radix Curcumae acrid flavour is bitter, cold in nature；There is the cool blood that clears away heart-fire, breaks analgesic of becoming silted up, liver soothing and depression relief, normalizing gallbladder to cure jaundice effect；Radix Curcumae and oriental wormwood It shares, there is drop enzyme drop wadding effect；Its ethanol extract can promote choleresis, shrink gall-bladder and bile is discharged, there is normalizing gallbladder to cure jaundice work With；Uranidin in Radix Curcumae can stimulate vascular wall, promote blood circulation, and improve portal vein blood circulation, and can inhibit fibr tissue And soft liver.
Radix Codonopsis is sweet in flavor, mild-natured；There is tonifying middle-Jiao and Qi, quench the thirst, strengthening spleen and tonifying lung, nourishes blood and promotes the production of body fluid.For spleen-lung Qi deficiency, deficiency of food is tired It is idle, false asthma cough, insufficiency of vital energy and blood, sallow complexion, palpitation, injury thirst, Heat Diabetes；It is improved immune effect.
Sealwort is sweet in flavor, mild-natured, there is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing；Sealwort, which has, increases B cell function, improves immune The effect of globulin.
Radix scrophulariae is sweet in flavor, bitter, salty, is slightly cold, clearing heat and cooling blood, nourishing yin and lessening fire, detoxicating and resolving a mass；Radix scrophulariae, which has, extends immunoglobulin The effect of half-life period.
Beneficial effects of the present invention are：For the present invention using cordate houttuynia, Radix Astragali as main ingredient, this two kinds of Chinese medicines can be effective as main ingredient Ground inhibits hepatopathy virus, promotes liver cell regeneration；This six kinds of Chinese medicines of Schisandra chinensis, Fructus Forsythiae, oriental wormwood, giant knotweed, scutellaria, Radix Curcumae are as auxiliary The effect of material coordinates main ingredient, and arrival is clearing heat and detoxicating, normalizing gallbladder to cure jaundice；Radix Codonopsis, sealwort, radix scrophulariae, these three Chinese medicines are reached as adjutant To tonifying Qi enriching yin, the effect of improving immunity；Radix Glycyrrhizae concocts all medicines, to make medicine；Heretofore described preparation method adopts Radix Curcumae It is extracted with ethyl alcohol, and at ambient temperature, greatly remains active ingredient in Radix Curcumae this taste Chinese medicine；And remove Radix Curcumae Chinese medicine material infusion concentrates, but also the cooperation of each taste herbal nature is more preferable, is finally dried to Chinese medicine stoste powdered so that this Chinese medicine preparation in invention can be conveniently added in the feed of duckling, alleviated the burden of poultry raiser, improved feeding efficiency； And preparation method of the present invention can largely retain medicinal ingredient and nutritional ingredient in Chinese medicine material, and make It is simply easy to spread to make method.
Specific implementation mode
With reference to embodiments, to the specific implementation mode that provides according to the present invention, details are as follows：
Embodiment 1
Heretofore described compound Chinese medicinal preparation is made of the material medicine of following parts by weight meter：25 parts of cordate houttuynia, 26 parts of Radix Astragali, 30 parts of Radix Glycyrrhizae, 12 parts of Schisandra chinensis, 15 parts of Fructus Forsythiae, 13 parts of oriental wormwood, 22 parts of giant knotweed, 11 parts of scutellaria, Radix Curcumae 12 divide, party 23 parts of ginseng, 12 parts of sealwort, 12 parts of radix scrophulariae.
The preparation method of above-mentioned compound Chinese medicinal preparation includes the following steps：
(1) feedstock processing：According to carry out raw material proportioning described above, is cleaned proportioned, dried after segment It is spare；
(2) Radix Curcumae ethyl alcohol extracts：It is powder that Radix Curcumae, which is crushed, and ethyl alcohol then is added into Radix Curcumae powder, is 20 in temperature 1 is impregnated under conditions of~25 DEG C, then uses filter-cloth filtering, after filtered filtrate is concentrated in vacuo to no ethyl alcohol outflow, Concentrate is collected, Radix Curcumae concentrate is made；
(3) it decocts：It will be mixed except the Chinese medicine material of Radix Curcumae, and add water thereto, and impregnate 30min after being heated to 45 DEG C, Then it boils, it is filtered later to respectively obtain liquid and the dregs of a decoction, boiling boiling, filtered liquid are then continuously added into the dregs of a decoction The liquid being obtained by filtration with first is uniformly mixed, and is made and is decocted liquid；
(4) concentration extraction：It will decoct and be uniformly mixed with Radix Curcumae concentrate after liquid is cooled to room temperature, admixing medical solutions are made, Then under vacuum by admixing medical solutions, temperature is to carry out concentration extraction at 50 DEG C, and then alcohol precipitation extracts to obtain Chinese medicine stoste；
(5) it dries：Chinese medicine stoste is dried, herb powder preparation is made.
Embodiment 2
A kind of compound Chinese medicinal preparation for preventing Duck Hepatitis Virus, which is by the original of following parts by weight meter Expect drug composition：20 parts of cordate houttuynia, 20 parts of Radix Astragali, 15 parts of Radix Glycyrrhizae, 10 parts of Schisandra chinensis, 10 parts of Fructus Forsythiae, 10 parts of oriental wormwood, giant knotweed 20 Part, 10 parts of scutellaria, Radix Curcumae 10 divides, 20 parts of Radix Codonopsis, 10 parts of sealwort, 10 parts of radix scrophulariae.
The preparation method of above-mentioned compound Chinese medicinal preparation includes the following steps：
(1) feedstock processing：According to carry out raw material proportioning described above, is cleaned proportioned, dried after segment It is spare；
(2) Radix Curcumae ethyl alcohol extracts：It is powder that Radix Curcumae, which is crushed, and ethyl alcohol then is added into Radix Curcumae powder, is 20 in temperature 2h is impregnated under conditions of~25 DEG C, then uses filter-cloth filtering, after filtered filtrate is concentrated in vacuo to no ethyl alcohol outflow, Concentrate is collected, Radix Curcumae concentrate is made；
(3) it decocts：It will be mixed except the Chinese medicine material of Radix Curcumae, and add water thereto, and 1h be impregnated after being heated to 45 DEG C, then It boils, it is filtered later to respectively obtain liquid and the dregs of a decoction, boiling boiling, filtered liquid and the are then continuously added into the dregs of a decoction One liquid being obtained by filtration is uniformly mixed, and is made and is decocted liquid；
(4) concentration extraction：It will decoct and be uniformly mixed with Radix Curcumae concentrate after liquid is cooled to room temperature, admixing medical solutions are made, Then under vacuum by admixing medical solutions, temperature is to carry out concentration extraction at 70 DEG C, and then alcohol precipitation extracts to obtain Chinese medicine stoste；
(5) it dries：Chinese medicine stoste is dried, herb powder preparation is made.
Embodiment 3
A kind of compound Chinese medicinal preparation for preventing Duck Hepatitis Virus, which is by the original of following parts by weight meter Expect drug composition：28 parts of cordate houttuynia, 27 parts of Radix Astragali, 35 parts of Radix Glycyrrhizae, 16 parts of Schisandra chinensis, 16 parts of Fructus Forsythiae, 11 parts of oriental wormwood, giant knotweed 23 Part, 14 parts of scutellaria, Radix Curcumae 12 divides, 21 parts of Radix Codonopsis, 13 parts of sealwort, 14 parts of radix scrophulariae.
The preparation method of above-mentioned compound Chinese medicinal preparation includes the following steps：
(1) feedstock processing：According to carry out raw material proportioning described above, is cleaned proportioned, dried after segment It is spare；
(2) Radix Curcumae ethyl alcohol extracts：It is powder that Radix Curcumae, which is crushed, and ethyl alcohol then is added into Radix Curcumae powder, is 20 in temperature 1.5h is impregnated under conditions of~25 DEG C, then uses filter-cloth filtering, and filtered filtrate, which is concentrated in vacuo to no ethyl alcohol, to be flowed out Afterwards, concentrate is collected, Radix Curcumae concentrate is made；
(3) it decocts：It will be mixed except the Chinese medicine material of Radix Curcumae, and add water thereto, and impregnate 45min after being heated to 45 DEG C, Then it boils, it is filtered later to respectively obtain liquid and the dregs of a decoction, boiling boiling, filtered liquid are then continuously added into the dregs of a decoction The liquid being obtained by filtration with first is uniformly mixed, and is made and is decocted liquid；
(4) concentration extraction：It will decoct and be uniformly mixed with Radix Curcumae concentrate after liquid is cooled to room temperature, admixing medical solutions are made, Then under vacuum by admixing medical solutions, temperature is to carry out concentration extraction at 65 DEG C, and then alcohol precipitation extracts to obtain Chinese medicine stoste；
(5) it dries：Chinese medicine stoste is dried, herb powder preparation is made.
Compound Chinese medicinal preparation will be prepared described in embodiment 1, embodiment 2, embodiment 3 respectively according to 50~100g/kg's Dosage is added in the feed of duckling, and one day feeding is primary, and continuous is 5 days；Control group is not added to duckling feeding The amount for the feed for adding heretofore described feed, and feeding daily is identical as embodiment 1, embodiment 2 and embodiment 3,30 days Afterwards, compare duckling duck viral hepatitis incidence, the results are shown in Table 1：
Feed duckling number (only) Morbidity duckling number (only) Incidence (%)
Embodiment 1 400 29 7.25
Embodiment 2 400 35 8.75
Embodiment 3 400 37 9.25
Control group 400 67 16.75
As can be seen from Table 1 in embodiment 1, embodiment 2, embodiment 3 Duck Hepatitis Virus incidence 10% with Under, and the incidence of the duck virus hepatitis in control group is up to 16.75%, this illustrates heretofore described Chinese medicine compound prescription system Agent can effectively prevent the generation of Duck Hepatitis Virus；From table 1 it is also seen that the proportioning in embodiment 1 is optimal.
The above-mentioned detailed description carried out to the compound Chinese medicinal preparation for preventing Duck Hepatitis Virus with reference to embodiment, is explanation Property rather than restriction, several embodiments can be enumerated according to limited range, therefore do not departing from present general inventive concept Under change and modification, protection scope of the present invention etc should be belonged to.

Claims (3)

1. a kind of compound Chinese medicinal preparation for preventing Duck Hepatitis Virus, which is characterized in that the Chinese medicine is by following weight The material medicine of number meter forms：20~30 parts of cordate houttuynia, 20~30 parts of Radix Astragali, 15~40 parts of Radix Glycyrrhizae, 10~20 parts of Schisandra chinensis, 10~20 parts of Fructus Forsythiae, 10~15 parts of oriental wormwood, 20~25 parts of giant knotweed, 10~15 parts of scutellaria, 10~15 points of Radix Curcumae, Radix Codonopsis 20~25 Part, 10~15 parts of sealwort, 10~15 parts of radix scrophulariae.
2. a kind of compound Chinese medicinal preparation for preventing Duck Hepatitis Virus according to claim 1, which is characterized in that The Chinese medicine is made of the material medicine of following parts by weight meter：25 parts of cordate houttuynia, 26 parts of Radix Astragali, 30 parts of Radix Glycyrrhizae, Schisandra chinensis 12 Part, 15 parts of Fructus Forsythiae, 13 parts of oriental wormwood, 22 parts of giant knotweed, 11 parts of scutellaria, Radix Curcumae 12 divides, 23 parts of Radix Codonopsis, 12 parts of sealwort, 12 parts of radix scrophulariae.
3. a kind of preparation method for preventing the compound Chinese medicinal preparation of Duck Hepatitis Virus, which is characterized in that including following Step：
(1) feedstock processing：Raw material proportioning will be carried out as claimed in claim 1 or 2, by the removal of impurities of proportioned material medicine, be cut It is dried for standby after section；
(2) Radix Curcumae ethyl alcohol extracts：It is powder that Radix Curcumae, which is crushed, and ethyl alcohol then is added into Radix Curcumae powder, is 20~25 in temperature 1~2h is impregnated under conditions of DEG C, then uses filter-cloth filtering, after filtered filtrate is concentrated in vacuo to no ethyl alcohol outflow, Concentrate is collected, Radix Curcumae concentrate is made；
(3) it decocts：It will be mixed except the Chinese medicine material of Radix Curcumae, and add water thereto, 30min~1h is impregnated after being heated to 45 DEG C, Then it boils, it is filtered later to respectively obtain liquid and the dregs of a decoction, boiling boiling, filtered liquid are then continuously added into the dregs of a decoction The liquid being obtained by filtration with first is uniformly mixed, and is made and is decocted liquid；
(4) concentration extraction：It will decoct and be uniformly mixed with Radix Curcumae concentrate after liquid is cooled to room temperature, admixing medical solutions are made, then Under vacuum by admixing medical solutions, temperature is to carry out concentration extraction at 50~70 DEG C, and then alcohol precipitation extracts to obtain Chinese medicine stoste；
(5) it dries：Chinese medicine stoste is dried, herb powder preparation is made.
CN201811022068.4A 2018-08-31 2018-08-31 It is a kind of to be used to prevent compound Chinese medicinal preparation of Duck Hepatitis Virus and preparation method thereof Pending CN108743888A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101953895A (en) * 2010-10-29 2011-01-26 张兴龙 Poultry antivirus traditional Chinese medical preparation and preparation method thereof
CN103041318A (en) * 2013-01-27 2013-04-17 吉林农业大学 Traditional Chinese medicine composition for treating gosling viral hepatitis
CN108210598A (en) * 2016-12-13 2018-06-29 河南后羿实业集团有限公司 A kind of Chinese medicine composition for treating duck virus hepatitis and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101953895A (en) * 2010-10-29 2011-01-26 张兴龙 Poultry antivirus traditional Chinese medical preparation and preparation method thereof
CN103041318A (en) * 2013-01-27 2013-04-17 吉林农业大学 Traditional Chinese medicine composition for treating gosling viral hepatitis
CN108210598A (en) * 2016-12-13 2018-06-29 河南后羿实业集团有限公司 A kind of Chinese medicine composition for treating duck virus hepatitis and preparation method thereof

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Application publication date: 20181106