CN108685746A - A kind of anti-mite shower cream or facial cleanser additive - Google Patents
A kind of anti-mite shower cream or facial cleanser additive Download PDFInfo
- Publication number
- CN108685746A CN108685746A CN201811016666.0A CN201811016666A CN108685746A CN 108685746 A CN108685746 A CN 108685746A CN 201811016666 A CN201811016666 A CN 201811016666A CN 108685746 A CN108685746 A CN 108685746A
- Authority
- CN
- China
- Prior art keywords
- mite
- skin
- diaryl
- facial cleanser
- shower cream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C[*+]c1cc(C(*)=O)ccc1 Chemical compound C[*+]c1cc(C(*)=O)ccc1 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention discloses a kind of anti-mite shower cream or facial cleanser additives.Skin is one of most important organ of human body, it undertakes each histoorgan of protection whole body and participates in the critical function of the various metabolic activities of body, and the health status of skin is very big on whole body health influence.Since skin is the outermost organ of human body, when various extraneous unfavorable factors attack to human body, skin often stands in the breach.Human Demodex is dispersed throughout the whole world, in the hair follicle and sebaceous glands for parasitizing human body extensively, is referred to as demodex folliculorum and demodex brevis.It can not be ignored the harm caused by skin, it not only damages skin health, but also cause a series of face dermatosis, hinder beauty.Diaryl lactam analog compound provided by the invention has excellent anti-mite effect, may be used as shower cream or anti-mite shower cream or anti-mite facial cleanser is made in facial cleanser additive.
Description
Technical field
The invention belongs to field of household chemical, it is related to a kind of anti-mite shower cream or facial cleanser additive.
Background technology
Skin is one of most important organ of human body, it has undertaken each histoorgan of protection whole body and participation body is various
The health status of the critical function of metabolic activity, skin is very big on whole body health influence.Since skin is human body outermost layer
Organ, when various extraneous unfavorable factors attack to human body, skin often stands in the breach.Human Demodex is dispersed throughout entirely
The world in the hair follicle and sebaceous glands for parasitizing human body extensively, is referred to as demodex folliculorum and demodex brevis.They can be unimpeded
Pore is unimpededly passed in and out, the cytoplasm liquid sucked in hair follicle and sebaceous glands makees nutritional ingredient and survives, and their breeding energy
Power is especially strong, can breed a generation within 14 days or so.Since its build is tiny, naked eyes are difficult to observe.According to data at home and abroad pair 90
The investigation of ten thousand people reports that mite infection rate is up to 68%~97%, and from birth, 48 days to 90 years old old men can infect, and feel
The dye person overwhelming majority is asymptomatic carrier.It can not be ignored the harm caused by skin, it not only damages skin
Health, but also cause a series of face dermatosis, hinder beauty.
Therefore, except mite daily chemical products have a vast market.
Invention content
The purpose of the present invention is to provide a kind of anti-mite shower cream or facial cleanser additives.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of diaryl lactam analog compound, chemical structural formula are as follows:
Wherein, R is:
Application of the above-mentioned diaryl lactam analog compound in preparing anti-mite shower cream.
Application of the above-mentioned diaryl lactam analog compound in preparing anti-mite facial cleanser.
Application of the above-mentioned diaryl lactam analog compound in preparing in terms of anti-mite daily use chemicals.
A kind of diaryl lactam analog compound, chemical structural formula are as follows:
Wherein, R is:
Application of the above-mentioned diaryl lactam analog compound in preparing anti-mite shower cream.
Application of the above-mentioned diaryl lactam analog compound in preparing anti-mite facial cleanser.
Application of the above-mentioned diaryl lactam analog compound in preparing in terms of anti-mite daily use chemicals.
A kind of diaryl lactam analog compound, chemical structural formula are as follows:
Wherein, R is:
Application of the above-mentioned diaryl lactam analog compound in preparing anti-mite shower cream.
Application of the above-mentioned diaryl lactam analog compound in preparing anti-mite facial cleanser.
Application of the above-mentioned diaryl lactam analog compound in preparing in terms of anti-mite daily use chemicals.
Advantageous effect:
Diaryl lactam analog compound provided by the invention has excellent anti-mite effect, may be used as shower cream or washes
Anti-mite shower cream or anti-mite facial cleanser is made in face milk additive.
Description of the drawings
Fig. 1 is the 6th, 11 day face mite negative conversion rate (%) of each group.
Specific implementation mode
It is specific with reference to the accompanying drawings and examples to introduce essentiality content of the present invention, but the guarantor of the present invention is not limited with this
Protect range.
One, experiment material
The structure of diaryl lactam analog compound to be tested is as follows, and self-control, purity is not less than 98%.
Two, experimental method
1, the preparation of anti-mite facial cleanser
Matrix formulations are as follows, are slowly stirred for 24 hours for 55 DEG C after each ingredient is mixed, natural cooling, cooling procedure continues to stir.
| Material name | W/% | Material name | W/% |
| Cetostearyl alcohol | 3 | Propylene glycol | 6 |
| Glyceryl monostearate | 2 | Triethanolamine | 0.3 |
| 15# White Mineral Oils | 8 | Sodium laureth sulfate (25%) | 6 |
| DC200 dimethicones | 3 | P-hydroxybenzoate | 0.2 |
| Vitamin E | 0.5 | Essence | 0.3 |
| Acritamer 940 | 0.3 | Deionized water | Add to 100 |
0.5% diaryl lactams 1~6 is added in above-mentioned matrix respectively to obtain containing diaryl lactams 1~6
Facial cleanser.
2, the preparation of anti-mite shower cream
Matrix formulations are as follows, are slowly stirred for 24 hours for 55 DEG C after each ingredient is mixed, natural cooling, cooling procedure continues to stir.
| Material name | W/% | Material name | W/% |
| Zetesol AP (70%) | 15 | Glycerine | 2 |
| Laruyl alcohol sulfosuccinate disodium | 6 | Acritamer 940 | 5 |
| Cocamidopropyl single ethanol amide | 1.5 | DP300 | 0.2 |
| Fatty acid distribution of coconut oil diglycollic amide | 2.5 | EDETATE SODIUM | 0.1 |
| Sodium lauroyl sarcosine | 5 | P-hydroxybenzoate | 0.2 |
| Pearlite slurry | 3 | Essence | 0.3 |
| Propyl betaine | 5 | Deionized water | Add to 100 |
0.5% diaryl lactams 1~6 is added in above-mentioned matrix respectively to obtain containing diaryl lactams 1~6
Shower cream.
3, the anti-mite measure of merit of anti-mite facial cleanser
In order to verify anti-mite effect, choosing 70 confirms that face has the subject (acarid is positive) of mite infestationss, every group of 10 people:
1~6 group of diaryl lactams:It is washed one's face respectively containing the anti-mite of diaryl lactams 1~6 using above-mentioned sooner or later daily
Milk face cleaning is primary, and specific face cleaning method is:The anti-mite facial cleanser of broad bean grain size is squeezed every time in the centre of the palm, and drop is several to drip in the centre of the palm
It rubs to spuming, is uniformly applied to face, and uniformly rubbing is 5 minutes facial back and forth;
Control group:Sooner or later primary using the matrix face cleaning without containing diaryl lactams 1~6 daily, face cleaning method is same as above.
Check whether face mite turns negative before the 6th day, early morning face cleaning on the 11st, inspection method is:With extruding
Method is tested, and is first squeezed in nose both sides and is taken fat, then the sebum squeezed out is scraped with knife, removed and be placed in from blade with needle point
In one drop sesame oil of clean object carrier on piece, it is sufficiently stirred and waits for that sebum is diluted in oil completely, observed with low power lens, not
It observes that acarid then illustrates to switch to acarid feminine gender, each group negative conversion rate (%) is calculated as follows.
Negative conversion rate (the %)=number of turning out cloudy/total number of persons × 100%
Three, experimental result
For experimental result as shown in table 1 and Fig. 1,1~5 group of the 6th day negative conversion rate of diaryl lactams is significantly higher than control group, the
It turns out cloudy completely within 11 days;And 6 group the 6th of diaryl lactams, 11 days negative conversion rates and control group are without significant difference.
Table the 6th, 11 day face mite negative conversion rate (%) of 1 each group
| Group | 6th day negative conversion rate (%) | 11st day negative conversion rate (%) |
| Control group | 10 | 20 |
| Diaryl lactams 1 | 70 | 100 |
| Diaryl lactams 2 | 60 | 100 |
| Diaryl lactams 3 | 70 | 100 |
| Diaryl lactams 4 | 70 | 100 |
| Diaryl lactams 5 | 60 | 100 |
| Diaryl lactams 6 | 10 | 20 |
The above results illustrate that diaryl lactams 1~5 has excellent anti-mite effect, may be used as shower cream or washes one's face
Anti-mite shower cream or anti-mite facial cleanser is made in milk additive.
The effect of above-described embodiment is specifically to introduce the essentiality content of the present invention, but those skilled in the art should know
Protection scope of the present invention should not be confined to the specific embodiment by road.
Claims (4)
1. a kind of diaryl lactam analog compound, which is characterized in that chemical structural formula is as follows.
Wherein, R is:
2. application of the diaryl lactam analog compound described in claim 1 in preparing anti-mite shower cream.
3. application of the diaryl lactam analog compound described in claim 1 in preparing anti-mite facial cleanser.
4. application of the diaryl lactam analog compound described in claim 1 in preparing in terms of anti-mite daily use chemicals.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811016666.0A CN108685746A (en) | 2018-09-03 | 2018-09-03 | A kind of anti-mite shower cream or facial cleanser additive |
| PCT/CN2018/114227 WO2020047991A1 (en) | 2018-09-03 | 2018-11-06 | Use of anti-acarid additive in daily chemical products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811016666.0A CN108685746A (en) | 2018-09-03 | 2018-09-03 | A kind of anti-mite shower cream or facial cleanser additive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108685746A true CN108685746A (en) | 2018-10-23 |
Family
ID=63841445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811016666.0A Withdrawn CN108685746A (en) | 2018-09-03 | 2018-09-03 | A kind of anti-mite shower cream or facial cleanser additive |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108685746A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020047991A1 (en) * | 2018-09-03 | 2020-03-12 | 范俊 | Use of anti-acarid additive in daily chemical products |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0452782A1 (en) * | 1990-04-13 | 1991-10-23 | Takeda Chemical Industries, Ltd. | Novel intermediates for preparing guanidine derivatives, their preparation and use |
| CN1214611A (en) * | 1996-04-03 | 1999-04-21 | 拜尔公司 | Pesticide for parasitic insects and acarids on humans |
| CN1217633A (en) * | 1996-05-06 | 1999-05-26 | 拜尔公司 | Arthropod repellant |
| CN1606406A (en) * | 2001-12-18 | 2005-04-13 | 美帝色斯医学制药集团 | Mitocidal compositions and methods |
| CN107235883A (en) * | 2016-03-29 | 2017-10-10 | 复旦大学 | Diaryl beta-lactam class compound and preparation method thereof and the purposes in pharmacy |
-
2018
- 2018-09-03 CN CN201811016666.0A patent/CN108685746A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0452782A1 (en) * | 1990-04-13 | 1991-10-23 | Takeda Chemical Industries, Ltd. | Novel intermediates for preparing guanidine derivatives, their preparation and use |
| CN1214611A (en) * | 1996-04-03 | 1999-04-21 | 拜尔公司 | Pesticide for parasitic insects and acarids on humans |
| CN1217633A (en) * | 1996-05-06 | 1999-05-26 | 拜尔公司 | Arthropod repellant |
| CN1606406A (en) * | 2001-12-18 | 2005-04-13 | 美帝色斯医学制药集团 | Mitocidal compositions and methods |
| CN107235883A (en) * | 2016-03-29 | 2017-10-10 | 复旦大学 | Diaryl beta-lactam class compound and preparation method thereof and the purposes in pharmacy |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020047991A1 (en) * | 2018-09-03 | 2020-03-12 | 范俊 | Use of anti-acarid additive in daily chemical products |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181023 |
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| WW01 | Invention patent application withdrawn after publication |