CN108680421B - Magnetic bead purifying instrument with compact structure and high stability - Google Patents
Magnetic bead purifying instrument with compact structure and high stability Download PDFInfo
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- CN108680421B CN108680421B CN201810794408.9A CN201810794408A CN108680421B CN 108680421 B CN108680421 B CN 108680421B CN 201810794408 A CN201810794408 A CN 201810794408A CN 108680421 B CN108680421 B CN 108680421B
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- bearing
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- step hole
- magnetic bead
- hole
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- 239000011324 bead Substances 0.000 title claims abstract description 32
- 230000007246 mechanism Effects 0.000 claims abstract description 38
- 238000000746 purification Methods 0.000 claims abstract description 7
- 230000001360 synchronised effect Effects 0.000 claims description 13
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 8
- 235000017166 Bambusa arundinacea Nutrition 0.000 abstract description 4
- 235000017491 Bambusa tulda Nutrition 0.000 abstract description 4
- 241001330002 Bambuseae Species 0.000 abstract description 4
- 235000015334 Phyllostachys viridis Nutrition 0.000 abstract description 4
- 239000011425 bamboo Substances 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 13
- 102000039446 nucleic acids Human genes 0.000 description 11
- 108020004707 nucleic acids Proteins 0.000 description 11
- 150000007523 nucleic acids Chemical class 0.000 description 11
- 238000005119 centrifugation Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000001821 nucleic acid purification Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Centrifugal Separators (AREA)
Abstract
The utility model provides a compact structure, high magnetic bead purification appearance of stability, the on-line screen storage device comprises a base, swing mechanism and the rotary mechanism of setting on swing mechanism of setting on the base, the through-hole at the middle part of swing dish includes first, second step hole and the straight section of thick bamboo of intercommunication first, second step hole, third step hole has in the stator, rotary mechanism is including inserting the collecting ring of locating in the straight section of thick bamboo, the plane thrust bearing of setting on first step hole, the rotor of setting on plane thrust bearing, the cover locate the rotor outside and be located the bearing in the third step hole of stator, and the rotary disk of one end fixed connection with the rotor, the outside of one end of rotor has the flange, the bearing clamp is located between flange and the apron. The shaking function and the centrifugal movement are integrated, a reagent tube is not required to be transferred, the operation is simple, the efficiency is high, the structure is compact, and the stability is high.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a magnetic bead purifying instrument with compact structure and high stability.
Background
Nucleic acids are widely found in animals and plants. In the medical field, it is often necessary to extract nucleic acids from a liquid, a process known as nucleic acid purification. One of the nucleic acid purification methods is a magnetic bead method, wherein the magnetic bead method utilizes a magnetic rod or a magnetic plate to adsorb nano magnetic beads, and the nano magnetic beads adsorb nucleic acid. In the process, body fluid and other reagents are injected into a reagent tube, the liquids of the reagent tube are required to be mixed, so that the body fluid and the other reagents are uniformly mixed, and then magnetic beads adsorbed with nucleic acid are moved from one tube to the other tube by utilizing the movement of a magnetic rod or liquid suction, so that the purposes of purifying and eluting the nucleic acid are achieved. Another method for purifying nucleic acid is a centrifugal column method, in which a body fluid is introduced into a centrifugal column, nucleic acid is adsorbed on the centrifugal column, and the nucleic acid is washed by centrifugal motion, and finally the target substance is eluted from the centrifugal column. The existing mode correspondingly requires two devices to respectively carry out mixing, magnetic transfer or pipetting (a magnetic bead method) and centrifugation (a centrifugal column method), and the centrifugal column method also comprises a plurality of manual centrifugation steps, so that the occupied area of the devices is large, the operation is more troublesome and the efficiency is lower. Meanwhile, the biological extraction has higher requirements on the stability of equipment. In addition, the existing nucleic acid purification method has the processes of repeated mixing, magnetic transfer or pipetting and centrifugation in the experimental process, and the nucleic acid substances are exposed to the air for a plurality of times, so that aerosol is likely to be formed, cross contamination is caused, and erroneous results are caused.
Disclosure of Invention
In view of the above, the invention provides a magnetic bead purifier which integrates shaking function and centrifugal movement, does not need to transfer a reagent tube, and has the advantages of simple operation, higher efficiency, compact structure, small occupied area, high stability, compact structure with high stability and high stability, so as to solve the problems.
The utility model provides a compact structure, high stability's magnetic bead purification appearance, compact structure, high stability's magnetic bead purification appearance includes a base (10), a swing mechanism (20) of setting on base (10), and a rotary mechanism (30) of setting on swing mechanism (20), swing mechanism (20) include two pivot (21) that the interval set up, one set up swing dish (22) between two pivot (21), one with swing dish (22) keep away from one side fixed connection of base (10) stator (23), and cover board (24) of locating on stator (23) fixed cover, the middle part of swing dish (22) is equipped with the through-hole, the through-hole includes a first step hole (221), a second step hole (222) and a straight section of thick bamboo (223) of intercommunication first, second step hole, the middle part of stator (23) has third step hole (231), rotary mechanism (30) include one insert locate in straight section of thick bamboo (21) ring (31), one set up in first step hole (33), one set up thrust sleeve (32) on the bearing (33) of the thrust sleeve (32) of setting up on the first step hole (33), and a rotating disc (35) fixedly connected with one end of the rotor (33) far away from the base (10), wherein the collecting ring (31) comprises an outer ring (311) and an inner ring (312) rotatably inserted in the outer ring (311), one end of the outer ring (311) facing the base (10) is fixedly arranged in the second step hole (222), the outer side of one end of the rotor (33) facing the base (10) is provided with a flange (331), and the bearing (34) is clamped between the flange (331) and the cover plate (24).
Further, swing mechanism (20) still include one set up swing motor (25) on base (10), one with the terminal fixed connection's of pivot (21) synchronous pulley (26) to and connect output shaft and synchronous pulley (26) hold-in range (27) of swing motor (25), base (10) include a bottom plate (11) and two perpendicular and interval set up support (12) on bottom plate (11), the top of support (12) is equipped with first through-hole (121), is equipped with first bearing (13) in first through-hole (121), pivot (21) pass first bearing (13) and are connected with synchronous pulley (26).
Further, the rotating mechanism (30) further comprises a rotating motor (36) arranged on one side of the swinging disc (22) facing the base (10), and an output shaft of the rotating motor (36) penetrates through the straight cylinder (223) and the collecting ring (31) and is connected with the rotor (33).
Further, a fourth step hole (332) is formed in the side surface, facing the base (10), of the rotor (33), the fourth step hole (332) and the first step hole (221) of the swing disc (22) form a containing section, and the plane thrust bearing (32) is located in the containing section.
Further, the swinging motor (25) and the rotating motor (36) are servo motors with braking functions.
Further, a maximum distance from the third stepped hole (231) of the stator (23) to the wobble plate (22) is equal to a maximum distance from the flange (331) of the rotor (33) to the wobble plate (22), so that the bearing (34) is placed on the third stepped hole (231) and the flange (331).
Further, a flange (313) is arranged at the circumferential edge of one end, facing the base, of the outer ring (311) of the collecting ring (31), and the flange (313) is fixedly arranged on the second step hole (222).
Further, the bearing (34) comprises an inner bearing ring and an outer bearing ring which is arranged at intervals with the inner bearing ring, the diameter of the third step hole (231) is equivalent to the inner diameter of the inner bearing ring, and the outer diameter of the flange (331) is equivalent to the outer diameter of the outer bearing ring.
Further, the bearing (34) is a double row ball bearing.
Further, a tray (38) is further connected to one side, far away from the base (10), of the rotating disc (35), and the vertical distance between the first end of the tray (38) and the rotating disc (35) is greater than the vertical distance between the second end of the tray (38) and the rotating disc (35).
Compared with the prior art, the magnetic bead purifying instrument with compact structure and high stability comprises a base (10), a swinging mechanism (20) arranged on the base (10), and a rotating mechanism (30) arranged on the swinging mechanism (20), wherein the swinging mechanism (20) comprises two rotating shafts (21) arranged at intervals, a swinging disc (22) arranged between the two rotating shafts (21), a stator (23) fixedly connected with one side, far away from the base (10), of the swinging disc (22), and a cover plate (24) fixedly covered on the stator (23), the middle part of the swinging disc (22) is provided with a through hole, the through hole comprises a first step hole (221), a second step hole (222) and a straight barrel (223) communicated with the first step hole and the second step hole, the middle part of the stator (23) is provided with a third step hole (231), the rotating mechanism (30) comprises a collector ring (31) inserted in the straight barrel (223), a step hole (221) arranged on the first step hole (221) and a thrust sleeve (32) arranged on the first step hole (33) and a thrust sleeve (32) arranged on the thrust sleeve (32) and positioned on the outer side of the first bearing (33), and a rotating disc (35) fixedly connected with one end of the rotor (33) far away from the base (10), wherein the collecting ring (31) comprises an outer ring (311) and an inner ring (312) rotatably inserted in the outer ring (311), one end of the outer ring (311) facing the base (10) is fixedly arranged in the second step hole (222), the outer side of one end of the rotor (33) facing the base (10) is provided with a flange (331), and the bearing (34) is clamped between the flange (331) and the cover plate (24). The shaking function and the centrifugal movement are integrated, a reagent tube is not required to be transferred, the operation is simple, the efficiency is high, the structure is compact, the occupied area is small, and the stability is high.
Drawings
Embodiments of the invention are described below with reference to the accompanying drawings, in which:
FIG. 1 is a schematic perspective view of a magnetic bead purifier with compact structure and high stability.
FIG. 2 is a schematic diagram showing a schematic diagram of a front cross section of a magnetic bead purifier with compact structure and high stability.
FIG. 3 is an exploded schematic view of the magnetic bead purifier of FIG. 2 with compact structure and high stability.
Fig. 4 is a schematic side view of the slip ring of fig. 3.
Fig. 5 is a schematic side view of the planar thrust bearing of fig. 3.
Invention of the inventionDetailed Description
Specific embodiments of the present invention will be described in further detail below based on the drawings. It should be understood that the description herein of the embodiments of the invention is not intended to limit the scope of the invention.
Referring to fig. 1 to 3, which are schematic perspective views of a magnetic bead purifier with compact structure and high stability according to the present invention, the magnetic bead purifier includes a base 10, a swing mechanism 20 disposed on the base 10, and a rotation mechanism 30 disposed on the swing mechanism 20. It is conceivable that the magnetic bead purifier with compact structure and high stability further includes other functional modules such as an assembly module, a mounting module, and an electrical connection module, which are known technologies to those skilled in the art, and will not be described in detail herein.
The base 10 comprises a bottom plate 11 and two brackets 12 which are perpendicular to each other and are arranged on two sides of the bottom plate 11 at intervals, a first through hole 121 is formed in the top of each bracket 12, and a first bearing 13 is arranged in each first through hole 121. The base plate 11 provides planar support for the whole equipment and is made of high-strength steel.
The swing mechanism 20 includes two rotating shafts 21 arranged at intervals, a swing disc 22 arranged between the two rotating shafts 21, a stator 23 fixedly connected with one side of the swing disc 22 away from the base 10, and a cover plate 24 fixedly covered on the stator 23, wherein the two rotating shafts 21 respectively pass through two first bearings 13, and the first bearings 13 are used for supporting the rotating shafts 21 with smaller resistance. The middle part of the swing disc 22 is provided with a through hole, the through hole comprises a first step hole 221, a second step hole 222 and a straight barrel 223 communicated with the first step hole and the second step hole, wherein the first step hole 221 is far away from the base 10, and the second step hole 222 is arranged towards the base 10. The stator 23 has a third stepped hole 231 at the middle thereof.
The rotating mechanism 30 includes a slip ring 31 inserted in the straight cylinder 223, a planar thrust bearing 32 provided on the first stepped hole 221, a rotor 33 provided on the planar thrust bearing 32, a bearing 34 fitted on the outside of the rotor 33 and positioned in the third stepped hole 231 of the stator 23, and a rotating disk 35 fixedly connected to an end of the rotor 33 remote from the base 10.
Referring to fig. 4, the collecting ring 31 includes an outer ring 311 and an inner ring 312 rotatably inserted in the outer ring 311, wherein a flange 313 is disposed at a circumferential edge of one end of the outer ring 311 facing the base 10, one end of the outer ring 311 facing the base 10 is located in the second stepped hole 222, and the flange 313 is fixedly connected with the bottom of the second stepped hole 222, so that positioning of the collecting ring 31 is achieved and mounting reliability of the collecting ring 31 is improved.
Referring to fig. 5, the planar thrust bearing 32 includes a first ring 321 and a second ring 322 disposed at intervals, and a plurality of balls 323 disposed between the first ring 321 and the second ring 322. The second ring 322 is fixed relative to the wobble plate 22, the first ring 321 is fixed relative to the rotor 33, the planar thrust bearing 32 supports the rotor 33 at the bottom, and when the rotor 33 rotates, the first ring 321 can rotate relative to the second ring 322, and the balls play roles in supporting, reducing friction and resistance.
Referring again to fig. 3, the outer side of the end of the rotor 33 facing the base 10 has a flange 331, and the bearing 34 is sandwiched between the flange 331 and the cover 24. The bearing 34 supports the rotor 33 circumferentially. The bearing 34 includes an inner bearing ring and an outer bearing ring spaced from the inner bearing ring. The maximum distance from the third stepped hole 231 of the stator 23 to the wobble plate 22 is equal to the maximum distance from the flange 331 of the rotor 33 to the wobble plate 22 to place the bearing 34 on the third stepped hole 231 and the flange 331. The diameter of the third stepped hole 231 is equal to the inner diameter of the bearing inner ring, and the outer diameter of the flange 331 is equal to the outer diameter of the bearing outer ring. In this embodiment, the bearing 34 is a double row ball bearing.
Since the bearing 34 is located in the stator 23 and between the flange 331 of the rotor 33 and the cover plate 24, the rotor 33 is supported by the planar thrust bearing 32, and the planar thrust bearing 32 is located in the first step hole 221 of the swing disc 22, the overall structure is compact, the planar thrust bearing 32 supports the rotor 33 in a bottom manner, and the bearing 34 supports the rotor 33 in a circumferential and lateral direction, so that the stability of the rotating mechanism 30 is improved, and shaking is not easy to occur during rotation or swing.
The middle part of the end of the rotor 33 facing the base 10 is further provided with a fourth step hole 332, the fourth step hole 332 of the rotor 33 and the first step hole 221 of the swing disc 22 form a containing section, the planar thrust bearing 32 is located in the containing section, that is, the first ring 321 of the planar thrust bearing 32 is located in the fourth step hole 332, and the second ring 322 is located in the first step hole 221.
The swinging mechanism 20 further comprises a swinging motor 25 arranged on the bottom plate 11, a synchronous pulley 26 fixedly connected with the tail end of the rotating shaft 21, and a synchronous belt 27 connecting the output shaft of the swinging motor 25 with the synchronous pulley 26, wherein the rotating shaft 21 passes through the first bearing 13 and is connected with the synchronous pulley 26.
The swinging motor 25 drives the synchronous pulley 26 and the swinging disk 22 to swing within a specific angle range through the synchronous belt 27, so that the rotating mechanism 30 arranged on the swinging disk 22 and the test tube arranged on the rotating mechanism 30 swing within a specific angle range, and the substances in the test tube are uniformly shaken.
The rotation mechanism 30 further includes a rotating electric machine 36 provided on a side of the swing disk 22 facing the base 10, and an output shaft 361 of the rotating electric machine 36 passes through the straight tube 223 and the slip ring 31 and is connected to the rotor 33.
The rotating motor 36 drives the rotor 33 to rotate in the stator 23, so as to drive the rotating disk 35 and the test tube arranged on the rotating disk 35 to rotate together, and perform centrifugal movement, thereby separating substances in the test tube and obtaining substances such as desired nucleic acid.
Referring to fig. 3, a rotating bracket 37 and a tray 38 connected to one end of the rotating bracket 37 away from the base 10 are further disposed on the top of the rotating plate 35 away from the base 10. The side of the tray 38 remote from the base 10 is provided with a test tube rack 39. The rack 39 is used for placing the purification cartridge. The two ends of the tray 38 in the radial direction are different from the perpendicular distance of the rotating disk 35, i.e., the perpendicular distance of the first end of the tray 38 from the rotating disk 35 is greater than the perpendicular distance of the second end of the tray 38 from the rotating disk 35. The end of the purification cartridge near the second end of the tray 38 is provided with a collection cartridge such that after the centrifugation is completed, the nucleic acid, protein, etc. materials collected in the collection cartridge near the second end of the tray 38 will remain in the collection cartridge without being returned to other parts of the purification cartridge.
The slip ring 31 is used to supply power at the rotary motor 36 to the rotary bracket 37 or the tray 38, and to supply power to the electronic devices provided at the rotary bracket 37 or the tray 38. The electronic device is connected to the inner ring 312 of the slip ring 31 by a cable, the rotating electric machine 36 is connected to the outer ring 311 of the slip ring 31 by a cable, the outer ring 311 is stationary with respect to the wobble plate 22, the inner ring 312 rotates together with the rotor 33, and the inner ring 312 is rotatably connected to the outer ring 311 and is electrically connected to the outer ring 311 inside the slip ring 31. Thus, when the rotor 33 is prevented from rotating, the cable is wound and twisted off, and the power supply problem of the electronic device arranged on the rotating bracket 37 or the tray 38 is solved.
When the test tube shaking device works, the swing motor 25 shakes test tubes uniformly, and after the rotating disc 22 and the test tube rack 39 return to the horizontal positions, the rotating motor 36 drives the rotating disc 35 and the test tube rack 39 to perform centrifugal motion.
In the present embodiment, the swing motor 25 and the rotary motor 36 are servo motors with braking function, and when the servo motors stop working, the output shaft thereof stops rotating immediately. This prevents excessive rocking and centrifugal movement.
Compared with the prior art, the magnetic bead purifying instrument with compact structure and high stability comprises a base 10, a swinging mechanism 20 arranged on the base 10 and a rotating mechanism 30 arranged on the swinging mechanism 20, wherein the swinging mechanism 20 comprises two rotating shafts 21 arranged at intervals, a swinging disc 22 arranged between the two rotating shafts 21, a stator 23 fixedly connected with one side of the swinging disc 22 far away from the base 10, and a cover plate 24 fixedly covered on the stator 23, the middle part of the swinging disc 22 is provided with a through hole, the through hole comprises a first step hole 221, a second step hole 222 and a straight barrel 223 communicated with the first step hole and the second step hole, the middle part of the stator 23 is provided with a third step hole 231, the rotating mechanism 30 comprises a collecting ring 31 inserted in the straight barrel 223, a plane thrust bearing 32 arranged on the first step hole 221, a rotor 33 arranged on the plane thrust bearing 32, a cover plate 24 fixedly connected with one side of the swinging disc 22 far away from the base 10, the through hole is formed in the middle part of the swinging disc 22, the through hole comprises a first step hole 221, a second step hole 222 and a straight barrel 223 communicated with the first step hole and the second step hole 222, the straight barrel 31 is arranged in the middle part of the collecting ring 31 and is far away from one end of the outer ring 35 arranged in the base 10, and is far away from the flange 35, and is fixedly connected with the first step hole 311 and the outer ring 33. The shaking function and the centrifugal movement are integrated, a reagent tube is not required to be transferred, the operation is simple, the efficiency is high, the structure is compact, the occupied area is small, and the stability is high.
The above is only a preferred embodiment of the present invention and is not intended to limit the scope of the present invention, and any modifications, equivalent substitutions or improvements within the spirit of the present invention are intended to be covered by the claims of the present invention.
Claims (10)
1. A magnetic bead purification appearance that compact structure, stability are high, its characterized in that: the magnetic bead purifying instrument with compact structure and high stability comprises a base (10), a swing mechanism (20) arranged on the base (10), and a rotating mechanism (30) arranged on the swing mechanism (20), wherein the swing mechanism (20) comprises two rotating shafts (21) arranged at intervals, a swing disc (22) arranged between the two rotating shafts (21), a stator (23) fixedly connected with one side, far away from the base (10), of the swing disc (22), and a cover plate (24) fixedly covered on the stator (23), the middle part of the swing disc (22) is provided with a through hole, the through hole comprises a first step hole (221), a second step hole (222) and a straight cylinder (223) communicated with the first step hole and the second step hole, the middle part of the stator (23) is provided with a third step hole (231), the rotating mechanism (30) comprises a collecting ring (31) inserted in the straight cylinder (223), a plane (221) arranged on the first step hole (221), a bearing (33) arranged on the first step hole (32), a thrust sleeve (33) arranged on the rotor (32) and a thrust sleeve (33) arranged on the outer side of the bearing (33), and a rotating disc (35) fixedly connected with one end of the rotor (33) far away from the base (10), wherein the collecting ring (31) comprises an outer ring (311) and an inner ring (312) rotatably inserted in the outer ring (311), one end of the outer ring (311) facing the base (10) is fixedly arranged in the second step hole (222), the outer side of one end of the rotor (33) facing the base (10) is provided with a flange (331), and the bearing (34) is clamped between the flange (331) and the cover plate (24).
2. The magnetic bead purifier with compact structure and high stability according to claim 1, wherein: the swing mechanism (20) further comprises a swing motor (25) arranged on the base (10), a synchronous pulley (26) fixedly connected with the tail end of the rotating shaft (21), and a synchronous belt (27) connected with an output shaft of the swing motor (25) and the synchronous pulley (26), the base (10) comprises a base plate (11) and two brackets (12) which are perpendicular to each other and are arranged on the base plate (11) at intervals, a first through hole (121) is formed in the top of the bracket (12), a first bearing (13) is arranged in the first through hole (121), and the rotating shaft (21) penetrates through the first bearing (13) and is connected with the synchronous pulley (26).
3. The magnetic bead purifier with compact structure and high stability according to claim 2, wherein: the rotating mechanism (30) further comprises a rotating motor (36) arranged on one side of the swinging disc (22) facing the base (10), and an output shaft of the rotating motor (36) penetrates through the straight cylinder (223) and the collecting ring (31) and is connected with the rotor (33).
4. The magnetic bead purifier with compact structure and high stability according to claim 1, wherein: the side of the rotor (33) facing the base (10) is provided with a fourth step hole (332), the fourth step hole (332) and the first step hole (221) of the swinging disc (22) form a containing section, and the plane thrust bearing (32) is positioned in the containing section.
5. The magnetic bead purifier with compact structure and high stability according to claim 3, wherein: the swinging motor (25) and the rotating motor (36) are servo motors with braking functions.
6. The magnetic bead purifier with compact structure and high stability according to claim 1, wherein: the maximum distance from the third stepped hole (231) of the stator (23) to the wobble plate (22) is equal to the maximum distance from the flange (331) of the rotor (33) to the wobble plate (22), so that the bearing (34) is placed on the third stepped hole (231) and the flange (331).
7. The magnetic bead purifier with compact structure and high stability according to claim 1, wherein: a flange (313) is arranged at the circumferential edge of one end, facing the base, of the outer ring (311) of the collecting ring (31), and the flange (313) is fixedly arranged on the second step hole (222).
8. The magnetic bead purifier with compact structure and high stability according to claim 1, wherein: the bearing (34) comprises a bearing inner ring and a bearing outer ring which is arranged at intervals with the bearing inner ring, the diameter of the third step hole (231) is equal to the inner diameter of the bearing inner ring, and the outer diameter of the flange (331) is equal to the outer diameter of the bearing outer ring.
9. The magnetic bead purifier with compact structure and high stability according to claim 8, wherein: the bearing (34) is a double row ball bearing.
10. The magnetic bead purifier with compact structure and high stability according to claim 1, wherein: one side of the rotating disc (35) far away from the base (10) is also connected with a tray (38), and the vertical distance between the first end of the tray (38) and the rotating disc (35) is greater than the vertical distance between the second end of the tray (38) and the rotating disc (35).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810794408.9A CN108680421B (en) | 2018-07-19 | 2018-07-19 | Magnetic bead purifying instrument with compact structure and high stability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810794408.9A CN108680421B (en) | 2018-07-19 | 2018-07-19 | Magnetic bead purifying instrument with compact structure and high stability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108680421A CN108680421A (en) | 2018-10-19 |
| CN108680421B true CN108680421B (en) | 2024-03-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810794408.9A Active CN108680421B (en) | 2018-07-19 | 2018-07-19 | Magnetic bead purifying instrument with compact structure and high stability |
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| Country | Link |
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| CN (1) | CN108680421B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872360B1 (en) * | 1998-10-14 | 2005-03-29 | Fondation Jean Dausset-Ceph | Centrifuging device for laboratory analyzer |
| CN101143884A (en) * | 2007-10-15 | 2008-03-19 | 吉林大学 | Nucleic acid automatic extracting instrument |
| CN105880041A (en) * | 2016-05-11 | 2016-08-24 | *** | Mechanism for simultaneously realizing functions of blending and centrifuging reagent |
| CN208334024U (en) * | 2018-07-19 | 2019-01-04 | 嘉兴医脉赛科技有限公司 | The magnetic beads for purifying instrument compact-sized, stability is high |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2835178B1 (en) * | 2013-08-06 | 2017-04-12 | Yantai AusBio Laboratories Co., Ltd. | Centrifuge and method for centrifuging a reaction vessel unit |
-
2018
- 2018-07-19 CN CN201810794408.9A patent/CN108680421B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872360B1 (en) * | 1998-10-14 | 2005-03-29 | Fondation Jean Dausset-Ceph | Centrifuging device for laboratory analyzer |
| CN101143884A (en) * | 2007-10-15 | 2008-03-19 | 吉林大学 | Nucleic acid automatic extracting instrument |
| CN105880041A (en) * | 2016-05-11 | 2016-08-24 | *** | Mechanism for simultaneously realizing functions of blending and centrifuging reagent |
| CN208334024U (en) * | 2018-07-19 | 2019-01-04 | 嘉兴医脉赛科技有限公司 | The magnetic beads for purifying instrument compact-sized, stability is high |
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| Publication number | Publication date |
|---|---|
| CN108680421A (en) | 2018-10-19 |
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