CN108633892A - Bactericidal composition containing psoralen and octyl trichlamide - Google Patents
Bactericidal composition containing psoralen and octyl trichlamide Download PDFInfo
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- CN108633892A CN108633892A CN201810340235.3A CN201810340235A CN108633892A CN 108633892 A CN108633892 A CN 108633892A CN 201810340235 A CN201810340235 A CN 201810340235A CN 108633892 A CN108633892 A CN 108633892A
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- Prior art keywords
- psoralen
- octyl trichlamide
- bactericidal composition
- octyl
- trichlamide
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of containing the bactericidal composition that active ingredient is psoralen and octyl trichlamide, including usual auxiliaries, psoralen and octyl trichlamide, and the quality parts ratio of psoralen and octyl trichlamide is 4:1~1:6, preferably than being 1:1~1:4.Psoralen and there is synergistic effect to pathogen fungi after being compounded in certain proportion with octyl trichlamide, is suitable for prevention by the fungus-caused crop disease of pathogen.
Description
Technical field
The invention belongs to synergetic pesticide composition fields, and in particular to one kind containing active constituent psoralen and octyl trichlamide
Composition pesticide.
Background technology
Psoralen (Psoralen)), also known as psoralen, Methoxypsoralen, CAS accession number 66-97-7.Chinese patent
CN102067850A discloses purposes of the psoralen as agricultural bacteriocide or insecticide, and psoralen is from natural plants
It isolates and purifies to obtain or commercially available.
Octyl trichlamide is a kind of environment-friendly type amino acids high molecular polymer fungicide, the organosilicon of composition containing synergy and mew
Class sterilization factors are high-tech of new generation, environment-friendly type, high-efficiency broad spectrum, less toxic fungicide, can generate ionization in aqueous solution,
Strong electropositive is contained in hydrophilic group part, and absorption is usually in all kinds of bacteriums of negative electricity, virus to inhibit bacterium, virus
Breeding solidifies germ protein, is the denaturation of germ enzyme system, in addition the film that polymer is formed plugs this part microorganism
Ion channel makes its death by suffocation immediately, and to reach best bactericidal effect, broad-spectrum has absorbability and extremely strong
Permeability also has upward, downward, biaxial flexural member effect, has and protect, treat, rooting out, raising four big functions, thin to killing
Fungal disease is once completed.
It is one of prevention most effective chemical means of phytopathogen using chemical agent；With the novel pesticide of not cross resistance
It is a good solution to carry out controlling plant diseases；But one novel pesticide of exploitation needs to screen a chemical combination up to ten thousand at present
Object, hundred million dollars of cost 1.2-1.5, the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs；It is other
Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research
Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
The synergistic combination of psoralen and octyl trichlamide has not been reported, and the mechanism of action and effect of psoralen and octyl trichlamide are special
Point is different.
Invention content
The present invention is intended to provide a kind of Synergistic bactericidal composition containing psoralen and octyl trichlamide, anti-convenient for crop disease
Property management, health control and reduce Pesticide use amount.
The invention is realized by the following technical scheme：
Bactericidal composition containing psoralen and octyl trichlamide, active constituent be psoralen and octyl trichlamide, preferably
The mass fraction ratio of psoralen and octyl trichlamide is 4:1~1:6.
The mass fraction ratio of further preferred psoralen and octyl trichlamide is 1:1~1:4.
The mass fraction ratio of further preferred psoralen and octyl trichlamide is 1:1.
The mass fraction ratio of further preferred psoralen and octyl trichlamide is 1:2.
The mass fraction ratio of further preferred psoralen and octyl trichlamide is 1:3.
The mass fraction ratio of further preferred psoralen and octyl trichlamide is 1:4.
The bactericidal composition containing psoralen and octyl trichlamide removes and contains active constituent psoralen and octyl trichlamide
Outside, also contain auxiliary agent；The weight of active component is the 1%~30% of composition total weight, remaining is insecticides adjuvant.
The composition pesticide, being processed into microemulsion, water dispersible granules, granule etc., agriculturally common dosage form is just
In agriculturally using, aqueous suspension agent, aqueous emulsion, dispersible oil-suspending agent, missible oil, suspension emulsion, wettable powder can also be processed into
Other formulations of pesticide such as agent.
The present invention has the advantages that：
It is found by experiment that, psoralen is used in mixed way with octyl trichlamide to pythium (Pythium), Phytophthora
(Phytophthora), Peronospora (Peronospora), Pseudoperonospora (Pseudoperonospora), Sphaerotheca
(Sphaerotheca), Blumeria (Blumiria), Erysiphe (Erysiphe), Gibberella (Gibberella),
Sclerotinia (Sclerotinia), grape Sclerotinia (Botryotinia), Puccinia (Puccinia), Tilletia
(Tilletia), glue Rust (Gymnosporzngium), Phakopsora (Phakopsora), Ustilago (Ustilago),
Pyrenomycetes category (Rhizoctonia), Verticillium (Verticillium), Alternaria (Alternaria), Pyricularia Sacc.
(Pyriculara), Botrytis (Botrytis), Cercospora (Cercospora), Fusarium (Fusarium), colletotrichum
(Colletotrichum) etc. there is synergistic effect.
1, the composition pesticide provided by the invention containing active constituent psoralen and octyl trichlamide, psoralen and pungent bacterium
Amine has synergistic effect within the scope of certain proportion to the toxicity of target pathogen, such as Botrytis cinerea (Botrytis
cinerea)。
2, composition pesticide of the present invention has synergistic effect to target pathogen, it is possible to reduce Pesticide use amount reduces agriculture
The pollution of control of crop disease cost, mitigation to environment.
Specific implementation mode
Bactericidal composition containing psoralen and octyl trichlamide：Its granule dosage form weight percent group becomes：Psoralen
Fat element 1~10%, octyl trichlamide 1~20%, wetting agent 0.1~10%, binder 0.1~15%, carry dispersant 0.1~10%
Body complements to 100%.Specifically production stage is：Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, with super
Tiny pore pulverizer crushes, and through mediating, is then added in fluidized-bed granulation dryer and is granulated, dries, sieve, is made corresponding
The granule of weight percentage.
Bactericidal composition containing psoralen and octyl trichlamide：Dosage form of water dispersible granule weight percent group becomes：It mends
Bone fat element 1~10%, octyl trichlamide 1~20%, dispersant 0.1~15%, disintegrant 0.1~8%, wetting agent 0.1~5%, Gu
Body carrier complements to 100%.Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, with ultra micro air-flow crushing
Machine crushes, and through mediating, is then added in fluidized-bed granulation dryer and is granulated, dries, sieve, corresponding weight percent is made and contains
The water dispersible granules of amount.
Bactericidal composition containing psoralen and octyl trichlamide：Micro-emulsion form weight percent group becomes：Psoralea corylifolia
Element 1~10%, octyl trichlamide 1~20%, dispersant 0.1~15%, emulsifier 1-15%, solvent 0.1~30%, antifreezing agent 0.1
~5%, deionized water complements to 100%.Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, effectively at
Divide with after auxiliary agent dissolving, is placed in container and is sheared 5 minutes~2 hours with cutter, obtain the micro- of corresponding weight percentage
Emulsion.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur
One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be triphenoethyl benzene phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane, castor oil
One kind in polyoxyethylene ether, fatty alcohol polyoxy ether, aliphatic acid polyethenoxy ether, isomery alcohol.
The dispersant can be APES formaldehyde condensation product, naphthalene sulfonate, benzene sulfonate, to methoxy
Base fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fat
One kind in alcohol polyoxyethylene ether, polyethylene glycol stearate, Oleate, nekal, phosphate etc.
Or it is several.
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium,
Crospovidone, chitosan, sodium alginate, sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay,
One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine
Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin,
One or more of rosin, wood powder etc..
The solvent can be solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol, n-butanol, n-octyl alcohol, positive penta
Alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, ethyl acetate, methyl oleate, phthalic acid
Dibutyl ester, sec-Butyl Acetate.
The deionized water is industrial deionized water.
(1), raw to survey embodiment
According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association
Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index
(ATI)=(EC of standard agent50The EC of/reagent agent50)×100；The toxicity index of theoretical toxicity index TTI=A medicaments ×
In mixture in toxicity index × mixture of the percentage composition+B medicaments of A medicaments B medicaments percentage composition；Co-toxicity coefficient (CTC)=
[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100
Psoralen octyl trichlamide adopts the Toxicity Determination of Botrytis cinerea (Botrytis cinerea), subjects
Grey mould fruit rot of strawberry pathogen Botrytis cinerea (Botrytis cinerea) (mycelia growth method) from field.
The Toxicity Determination result of the 1 psoralen octyl trichlamide of table to Botrytis cinerea (Botrytis cinerea).
As shown in Table 1, psoralen and octyl trichlamide mixture are 4:1~1:Between 6, to Botrytis cinerea (Botrytis
Cinerea) there is synergistic effect, co-toxicity coefficient is 130 or more；Psoralen is with octyl trichlamide mixture 1:1~1:Between 4,
There is apparent synergistic effect to Botrytis cinerea (Botrytis cinerea), co-toxicity coefficient is 160 or more；And psoralen
With octyl trichlamide mixture 30:1~10:1 and 1:10~1:30 pairs of Botrytis cinereas (Botrytis cinerea) have no synergy and make
With co-toxicity coefficient is below 120.
(2), example of formulations
0.5% psoralen, 0.5% octyl trichlamide granule
Weigh 0.5% psoralen, 0.5% octyl trichlamide, 1% glucose, 1% corn flour, 3% rice chaff, balance kaolin.
Above-mentioned raw materials are uniformly mixed in mixed cylinder, and by extruding, granulation, drying, and 0.5% psoralen is made in screened step
0.5% octyl trichlamide granule.
3% psoralen, 3% octyl trichlamide water dispersible granules
Weigh 3% psoralen, 3% octyl trichlamide, 8% sodium butylnaphthalenesulfonate, 3% sodium lignin sulfonate, 3% tea seed cake powder,
4% sodium chloride, surplus white carbon.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by extruding, granulation, drying, and screened step
Suddenly 3% octyl trichlamide water dispersible granules of obtained 3% psoralen.
1% psoralen, 3% octyl trichlamide microemulsion
Take 1% psoralen, 3% octyl trichlamide, 3% n-butanol, 4% glycerine, 2% sec-Butyl Acetate, 3% poly alkyl alcohol
Ethylene oxide ether, mentioned component after mixing, are added deionized water and complement to 100%, be placed in container with 6000 turns per minute
Cutter shear 30 minutes, obtain 1% psoralen, 3% octyl trichlamide microemulsion.
(3), Application Example
Botrytis cinerea (Botrytis cinerea) causes various crop gray mold, as grey mould fruit rot of strawberry, graw mold of tomato,
Grape grey mould, lily gray mold etc..
2 1% psoralen of table, 3% octyl trichlamide microemulsion prevents the grey mould fruit rot of strawberry test of pesticide effectiveness (greenhouse, cauline leaf spraying；Often
45 liters of water of mu spraying)
2 data result of table shows that 1% psoralen, 3% octyl trichlamide microemulsion formulation dosage is watered 45 liters of cauline leafs for 15 grams per acre
Spraying there is preferable control effect, control effect to be used better than 400 grams per liter pyrimethanil preparations greenhouse strawberry gray mold
Amount is watered 45 liters of cauline leaf sprayings for 50 milliliters per acre.
3 1% psoralen of table, 3% octyl trichlamide microemulsion prevents the graw mold of tomato test of pesticide effectiveness (greenhouse, cauline leaf spraying；Often
45 liters of water of mu spraying)
3 data result of table shows that 1% psoralen, 3% octyl trichlamide microemulsion formulation dosage is watered 45 liters of cauline leafs for 15 grams per acre
Spraying there is preferable control effect, control effect to be used better than 400 grams per liter pyrimethanil preparations tomato in plastic greenhouse gray mold
Amount is watered 45 liters of cauline leaf sprayings for 50 milliliters per acre.
Claims (10)
1. the bactericidal composition containing psoralen and octyl trichlamide, it is characterised in that：Effective ingredient be psoralen and octyl trichlamide,
The mass fraction ratio of psoralen and octyl trichlamide is 4:1~1:6.
2. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of psoralen and octyl trichlamide
For：1:1~1:4.
3. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of psoralen and octyl trichlamide
For：1:1.
4. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of psoralen and octyl trichlamide
For：1:2.
5. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of psoralen and octyl trichlamide
For：1:3.
6. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of psoralen and octyl trichlamide
For：1:4.
7. bactericidal composition according to claim 1, it is characterised in that：The weight of the effective ingredient component is composition
The 1%~30% of total weight, remaining is insecticides adjuvant.
8. bactericidal composition according to claim 5, it is characterised in that：The dosage form of the bactericidal composition be granule,
One kind in water dispersible granules, microemulsion.
9. the bactericidal composition described in claim 4, it is characterised in that microemulsion preparation method is as follows：Take 1% psoralen,
3% octyl trichlamide, 3% n-butanol, 4% glycerine, 2% sec-Butyl Acetate, 3% fatty alcohol polyoxyethylene ether, mentioned component mixing
Uniformly after, be added deionized water complement to 100%, be placed in container with 6000 turns of cutter per minute shearing 30 minutes, i.e.,
1% psoralen, 3% octyl trichlamide microemulsion is made.
10. the bactericidal composition described in claim 1 to 6 any one is used to prevent the use of grey mould fruit rot of strawberry, graw mold of tomato
On the way.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810340235.3A CN108633892A (en) | 2018-04-16 | 2018-04-16 | Bactericidal composition containing psoralen and octyl trichlamide |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810340235.3A CN108633892A (en) | 2018-04-16 | 2018-04-16 | Bactericidal composition containing psoralen and octyl trichlamide |
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| CN108633892A true CN108633892A (en) | 2018-10-12 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109303074A (en) * | 2018-11-06 | 2019-02-05 | 于海峰 | The mix preparation of controlling plant diseases and its application |
| CN110178849A (en) * | 2019-05-24 | 2019-08-30 | 江苏省中国科学院植物研究所 | Purposes of the psoralen in prevention and treatment phytobacterial disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067850A (en) * | 2011-03-02 | 2011-05-25 | 江苏省中国科学院植物研究所 | Application of psoralen as agricultural disinfectant or pesticide |
| CN106359382A (en) * | 2016-08-31 | 2017-02-01 | 京博农化科技股份有限公司 | Bactericidal composition containing boscalid and octylamine |
-
2018
- 2018-04-16 CN CN201810340235.3A patent/CN108633892A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067850A (en) * | 2011-03-02 | 2011-05-25 | 江苏省中国科学院植物研究所 | Application of psoralen as agricultural disinfectant or pesticide |
| CN106359382A (en) * | 2016-08-31 | 2017-02-01 | 京博农化科技股份有限公司 | Bactericidal composition containing boscalid and octylamine |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109303074A (en) * | 2018-11-06 | 2019-02-05 | 于海峰 | The mix preparation of controlling plant diseases and its application |
| CN110178849A (en) * | 2019-05-24 | 2019-08-30 | 江苏省中国科学院植物研究所 | Purposes of the psoralen in prevention and treatment phytobacterial disease |
| CN110178849B (en) * | 2019-05-24 | 2021-03-23 | 江苏省中国科学院植物研究所 | Application of psoralen in preventing and treating plant bacterial diseases |
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Address after: 610000 Northwest Biochemical Company, 388 Rongtai Avenue, Cross-Strait Science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Applicant after: Zhang Yuechan Address before: 516000 Room 206, Building 1, Kechuang Center, No. 1 Huatai Road, Huinan High-tech Industrial Park, Huizhou Zhongkai High-tech Zone, Guangdong Province Applicant before: Zhang Yuechan |
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