CN1085542C - Oral preparation of traditional Chinese medicine medicated composition for treating psoriasis and its preparation method - Google Patents
Oral preparation of traditional Chinese medicine medicated composition for treating psoriasis and its preparation method Download PDFInfo
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- CN1085542C CN1085542C CN98122877A CN98122877A CN1085542C CN 1085542 C CN1085542 C CN 1085542C CN 98122877 A CN98122877 A CN 98122877A CN 98122877 A CN98122877 A CN 98122877A CN 1085542 C CN1085542 C CN 1085542C
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Abstract
The present invention relates to an oral preparation of a traditional Chinese medicine composition and a preparing method thereof. The oral preparation comprises rosin, Chinese yam, oriental arborvitae, kakuda figwort root, coptis, cyrtomium rhizome, natural indigo and fineleaf schizonepeta herb. The oral preparation can be capsules, powder, tablets, granules and pills. The oral preparation for treating psoriasis of the present invention has the advantages of good treatment effect, high cure rate and safe and convenient application.
Description
The present invention relates to psoriatic Chinese medicine drug combination preparation of a kind of treatment and preparation method, be specifically related to treat the oral formulations and the preparation method of psoriatic Chinese medicine pharmaceutical composition.
Psoriasis is commonly called as psoriasis, is a kind of common, chronic, dermatosis of being easy to recur, and it mainly infects by heredity, blood and insects.Because psoriasis is a kind of obstinate dermatosis, be difficult to radical cure, so the title of " second carcinoid " is arranged, classified as the difficult problem that primary study is captured by domestic and international medical personnel.Psoriatic sickness rate is higher in China, and domestic total prevalence rate is 1.23%, and annual morbidity is 0.1%, up to the present, does not still have the medicine that can effect a radical cure both at home and abroad.Doctor trained in Western medicine often depends on medicines such as hormone, be difficult to lastingly but act on, and the toxic and side effects of medicine is big, and human body is had certain infringement, and the overwhelming majority fails to cure per capita.Comparatively speaking, the traditional Chinese medical science adopts the Therapeutic Method curative effect of theory of Chinese medical science to be better than doctor trained in Western medicine, but because problems such as human body difference, best prescription effective percentage also has only about 40%.
The objective of the invention is to capture the psoriatic difficulty of treatment, the psoriatic Chinese medicine drug composition oral preparation of treatment of a kind of good effect, cure rate height, safety, taking convenience is provided.
A kind of oral formulations for the treatment of psoriatic Chinese medicine pharmaceutical composition disclosed by the invention, be a kind of capsule, powder, tablet, granule or pill that contains former powder of 50～100% medicines and 0～50% pharmaceutic adjuvant, the former powder of its Chinese medicine is made up of medicines such as 40～50% Colophonium, 10～15% Rhizoma Dioscoreaes, 10～15% Cacumen Platycladis, 3～5% Radix Scrophulariae, 5～8% Rhizoma Coptidis, 10～15% Rhizoma Osmundae, 3～5% Indigo Naturaliss and 3～5% Herba Schizonepetae.
Another object of the present invention provides the preparation method of the oral formulations of the psoriatic pharmaceutical composition of treatment.The method of the above-mentioned oral formulations of preparation disclosed by the invention is: with crude drugs such as 40～50% Colophonium, 10～15% Rhizoma Dioscoreaes, 10～15% Cacumen Platycladis, 3～5% Radix Scrophulariae, 5～8% Rhizoma Coptidis, 10～15% Rhizoma Osmundae, 3～5% Indigo Naturaliss and 3～5% Herba Schizonepetae compatibility of weighing in proportion, through 120 ℃ of hyperthermia dryings, fully pulverize with pulverizer, it is standby that remix evenly becomes the former powder of medicine after 80 orders sieve.
Capsule disclosed by the invention be with the former powder fill of said medicine in the capsule ghost and make, make every capsules contain the former powder 100～500mg of medicine.
Powder disclosed by the invention is that the former powder of said medicine is packed respectively by different taking doses, makes each packing contain the former powder 100～5000mg of medicine.
Tablet disclosed by the invention is with the former powder of said medicine, adds an amount of binding agent, disintegrating agent, lubricant, and mix homogeneously, wet granulation are suppressed in flakes then, 70～80 ℃ of dryings 2～4 hours, makes every to contain the former powder 100～800mg of medicine.
Granule disclosed by the invention is with the former powder of said medicine, adds an amount of binding agent, disintegrating agent, lubricant, mix homogeneously, adding water makes soft material and sieves then and make granule, in 50～60 ℃ of dryings 2～4 hours, carry out packing again, make each packing contain the former powder 100～1200mg of medicine.
Pill disclosed by the invention is with the former powder of said medicine, adds proper amount of lubricating agent and binding agent, makes gob, through cut apart, round, 40～60 ℃ of dryings 2～6 hours, make every ball contain the former powder 100～1200mg of crude drug.
Used binding agent, disintegrating agent, lubricant, the wetting agent of the present invention is pharmaceutic adjuvant commonly used, can be any proportioning between them.Binding agent can be starch and derivant thereof, dextrin, gelatine size, Mel, rice paste, syrup etc.; Lubricant can be starch, magnesium stearate, aluminium hydroxide etc.; Lubricant can be water, water honey etc.; Disintegrating agent can be dried starch, carboxymethyl starch sodium etc.
The treatment theory that the present invention is traditional according to the traditional Chinese medical science, it is main taking to effect a permanent cure, taking stopgap measures is pair, and the method that treating both the principal and secondary aspects of a disease combines has clearing away heat and expelling pathogen in the exterior, supplementing QI and nourishing YIN, spleen reinforcing lung kidney, cooling blood for hemostasis, expelling pathogenic wind from the body surface, the effects such as swollen gram silver, removing dampness and killing parasites, removing toxic substances and promoting tissue regeneration of loosing.By the intravital long-pending poison of continuous eliminating, continuous strengthening vital QI to eliminate pathogenic factors, cooperate external bactericidal antiphlogistic medicine, suppress or the elimination focus.
It is to take every day to contain the former powder 3～5g of medicine that the present invention is used for clinical dosage.
Use oral formulations of the present invention to treat, toxicity takes place seldom, and removing has the very weak patient of gastropathy or body constitution initial several days idols discomfort to be arranged individually, and outside just having adapted to after several days, most patients do not have sense of discomfort.
With oral formulations treatment psoriasis of the present invention, effective percentage reaches more than 90%, and disease is improved obviously, and relapse rate is low, and has 20～30% patient thoroughly to cure.Oral formulations of the present invention has auxiliary antidotal therapy effect to multiple diseases such as hepatitis simultaneously.
The present invention is a a progressive step in treatment psoriasis field, provides that a kind of therapeutic effect is obvious, effective percentage is high, the compound Chinese medicinal preparation of safety, taking convenience.Because of treatment cycle and the expense of having shortened evident in efficacy, for the psoriatic has brought Gospel.
Embodiment 1,
2000 Colophonium, 500g Rhizoma Dioscoreae, 500g Cacumen Platycladi, 200g Radix Scrophulariae, 300g Rhizoma Coptidis, 500g Rhizoma Osmundae, 200g Indigo Naturalis, the mixing of 200g Herba Schizonepetae are placed 120 ℃ of oven dry of baking oven, cooling, fully pulverize with pulverizer, sieve with 80 mesh sieves, mix homogeneously is then packed respectively by taking dose and to be made each packing contain the former powder 100～5000mg of medicine.
Embodiment 2,
Make the former powder of medicine by example 1 method, fill makes every capsules contain the former powder 100～500mg of medicine in the hungry area softgel shell respectively.
Embodiment 3,
Make the former powder of medicine by embodiment 1 method, add starch 1300g, dextrin 600g, Icing Sugar 600g, magnesium stearate 40g, wet granulation compacting in flakes, promptly 70～80 ℃ of dryings 2～4 hours.
Embodiment 4,
Make the former powder of medicine by embodiment 1 method, add starch 1200g, lactose 700g, magnesium stearate 40g, mix thoroughly with gelatine size, make soft material, be screened into granule, in 50～60 ℃ of dryings 2～4 hours, carry out packing again, make each packing contain the former powder 100～1200mg of medicine.
Embodiment 5,
Make the former powder of medicine by embodiment 1 method, add water honey 4000g, rice is stuck with paste 2000g, makes gob, through cut apart, round, 40～60 ℃ of dryings 2～6 hours, make every ball contain the former powder 100～1200mg of crude drug.
Claims (4)
1, a kind of oral formulations for the treatment of psoriatic Chinese medicine pharmaceutical composition, the oral formulations that it is characterized in that described pharmaceutical composition are a kind of capsule, powder, tablet, granule or pills that contains former powder of 50～100% medicines and 0～50% pharmaceutic adjuvant; The former powder of medicine is made up of 40～50% Colophonium, 10～15% Rhizoma Dioscoreaes, 10～15% Cacumen Platycladis, 3～5% Radix Scrophulariae, 5～8% Rhizoma Coptidis, 10～15% Rhizoma Osmundae, 3～5% Indigo Naturaliss and 3～5% Herba Schizonepetae etc.
2, a kind of oral formulations for the treatment of psoriatic Chinese medicine pharmaceutical composition as claimed in claim 1 is characterized in that wherein said pharmaceutic adjuvant can be binding agent, disintegrating agent, lubricant or the wetting agent of using always.
3, a kind of oral formulations for the treatment of psoriatic Chinese medicine pharmaceutical composition as claimed in claim 1 or 2 is characterized in that the proportioning between wherein said each pharmaceutic adjuvant can be any ratio.
4, the preparation method of the oral formulations of the psoriatic Chinese medicine pharmaceutical composition of a kind of treatment as claimed in claim 1, it is characterized in that medical materials such as 40～50% Colophonium, 10～15% Rhizoma Dioscoreaes, 10～15% Cacumen Platycladis, 3～5% Radix Scrophulariae, 5～8% Rhizoma Coptidis, 10～15% Rhizoma Osmundae, 3～5% Indigo Naturaliss and 3～5% Herba Schizonepetae are mixed in proportion, through 120 ℃ of hyperthermia dryings, fully pulverize with pulverizer, mix homogeneously after 80 mesh sieves sieve is made the former powder of medicine;
(1) wherein said powder makes with following method: the former powder of said medicine is packed respectively by taking dose, made each packing contain the former powder 100～5000mg of medicine;
(2) wherein said capsule is made by following method: in the glue shell, make every capsules contain the former powder 100～500mg of medicine the former powder fill of said medicine.
(3) wherein said tablet is made by following method: with the former powder of said medicine, add an amount of binding agent, disintegrating agent, lubricant, mix homogeneously, wet granulation are suppressed in flakes then, 70～80 ℃ of dryings 2～4 hours, make every to contain the former powder 100～800mg of medicine;
(4) wherein said granule is made by following method: with the former powder of said medicine, add an amount of binding agent, disintegrating agent, lubricant; Mix homogeneously adds water and makes soft material and sieve then and make granule, in 50～60 ℃ of dryings 2～4 hours, carries out packing again, makes each packing contain the former powder 100～1200mg of medicine;
(5) wherein said pill is made by following method: with the former powder of said medicine, add proper amount of lubricating agent and binding agent, make gob, through cut apart, round, 40～60 ℃ of dryings 2～6 hours, make every ball contain the former powder 100～1200mg of crude drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98122877A CN1085542C (en) | 1998-12-25 | 1998-12-25 | Oral preparation of traditional Chinese medicine medicated composition for treating psoriasis and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98122877A CN1085542C (en) | 1998-12-25 | 1998-12-25 | Oral preparation of traditional Chinese medicine medicated composition for treating psoriasis and its preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1260184A CN1260184A (en) | 2000-07-19 |
| CN1085542C true CN1085542C (en) | 2002-05-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN98122877A Expired - Fee Related CN1085542C (en) | 1998-12-25 | 1998-12-25 | Oral preparation of traditional Chinese medicine medicated composition for treating psoriasis and its preparation method |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005094861A1 (en) * | 2004-04-02 | 2005-10-13 | Sung-Bae Park | Composition for treating psoriasis-associated diseases |
| CN112516250B (en) * | 2020-12-22 | 2022-02-15 | 黑龙江中医药大学附属第一医院（黑龙江中医药大学第一临床医学院） | Traditional Chinese medicine composition for treating psoriasis vulgaris and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1046461A (en) * | 1990-06-04 | 1990-10-31 | 亓镇 | A kind of method for making for the treatment of the psoriasis ointment |
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1998
- 1998-12-25 CN CN98122877A patent/CN1085542C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1046461A (en) * | 1990-06-04 | 1990-10-31 | 亓镇 | A kind of method for making for the treatment of the psoriasis ointment |
Non-Patent Citations (1)
| Title |
|---|
| 《中医药研究》1988年第5期 1988.1.11 韩世荣等；"松得临床应用与研究进展 * |
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| CN1260184A (en) | 2000-07-19 |
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