CN108508099B - 一种化妆品中3-亚苄基樟脑含量的测定方法 - Google Patents
一种化妆品中3-亚苄基樟脑含量的测定方法 Download PDFInfo
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- CN108508099B CN108508099B CN201710095365.0A CN201710095365A CN108508099B CN 108508099 B CN108508099 B CN 108508099B CN 201710095365 A CN201710095365 A CN 201710095365A CN 108508099 B CN108508099 B CN 108508099B
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- benzylidene camphor
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- OIQXFRANQVWXJF-QBFSEMIESA-N (2z)-2-benzylidene-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical compound CC1(C)C2CCC1(C)C(=O)\C2=C/C1=CC=CC=C1 OIQXFRANQVWXJF-QBFSEMIESA-N 0.000 title claims abstract description 43
- 239000002537 cosmetic Substances 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title claims abstract description 12
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims abstract description 57
- 239000007788 liquid Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 16
- 239000011259 mixed solution Substances 0.000 claims abstract description 15
- 238000004458 analytical method Methods 0.000 claims abstract description 11
- 238000001514 detection method Methods 0.000 claims abstract description 9
- 238000000605 extraction Methods 0.000 claims abstract description 8
- 239000011780 sodium chloride Substances 0.000 claims abstract description 8
- 239000012071 phase Substances 0.000 claims abstract description 7
- 239000007787 solid Substances 0.000 claims abstract description 7
- 238000010812 external standard method Methods 0.000 claims abstract description 6
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 45
- 239000000523 sample Substances 0.000 claims description 41
- 150000002500 ions Chemical class 0.000 claims description 19
- 239000000126 substance Substances 0.000 claims description 15
- 238000005303 weighing Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000004451 qualitative analysis Methods 0.000 claims description 5
- 238000004445 quantitative analysis Methods 0.000 claims description 5
- 239000012634 fragment Substances 0.000 claims description 4
- 238000001819 mass spectrum Methods 0.000 claims description 4
- 238000002390 rotary evaporation Methods 0.000 claims description 4
- 238000004817 gas chromatography Methods 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 2
- 238000010790 dilution Methods 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 239000012488 sample solution Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000013076 target substance Substances 0.000 abstract description 3
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 abstract description 2
- 238000011084 recovery Methods 0.000 abstract description 2
- 239000012535 impurity Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 description 13
- 238000007865 diluting Methods 0.000 description 9
- 239000006071 cream Substances 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- 239000012224 working solution Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 239000008271 cosmetic emulsion Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- OIQXFRANQVWXJF-UHFFFAOYSA-N 2-benzylidene-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical compound CC1(C)C2CCC1(C)C(=O)C2=CC1=CC=CC=C1 OIQXFRANQVWXJF-UHFFFAOYSA-N 0.000 description 1
- LQCUMCDCSNTCAZ-UHFFFAOYSA-N 4-[(4-tert-butylphenyl)methyl]phenol Chemical compound C1=CC(C(C)(C)C)=CC=C1CC1=CC=C(O)C=C1 LQCUMCDCSNTCAZ-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
- G01N2030/062—Preparation extracting sample from raw material
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
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CN201710095365.0A CN108508099B (zh) | 2017-02-23 | 2017-02-23 | 一种化妆品中3-亚苄基樟脑含量的测定方法 |
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CN201710095365.0A CN108508099B (zh) | 2017-02-23 | 2017-02-23 | 一种化妆品中3-亚苄基樟脑含量的测定方法 |
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CN108508099A CN108508099A (zh) | 2018-09-07 |
CN108508099B true CN108508099B (zh) | 2021-06-08 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090022815A (ko) * | 2007-08-31 | 2009-03-04 | (주)아모레퍼시픽 | 자외선차단 성분의 동시분석법 |
CN103063763A (zh) * | 2012-12-21 | 2013-04-24 | 林维宣 | 一种化妆品中多种紫外吸收剂残留量的高效液相色谱检测方法 |
KR101423585B1 (ko) * | 2012-10-11 | 2014-07-30 | 주식회사 제닉 | 자외선 차단 성분의 분석 방법 |
CN104020234A (zh) * | 2014-06-24 | 2014-09-03 | 东北林业大学 | 一种利用反胶束分离分析化妆品中着色剂的方法 |
-
2017
- 2017-02-23 CN CN201710095365.0A patent/CN108508099B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090022815A (ko) * | 2007-08-31 | 2009-03-04 | (주)아모레퍼시픽 | 자외선차단 성분의 동시분석법 |
KR101423585B1 (ko) * | 2012-10-11 | 2014-07-30 | 주식회사 제닉 | 자외선 차단 성분의 분석 방법 |
CN103063763A (zh) * | 2012-12-21 | 2013-04-24 | 林维宣 | 一种化妆品中多种紫外吸收剂残留量的高效液相色谱检测方法 |
CN104020234A (zh) * | 2014-06-24 | 2014-09-03 | 东北林业大学 | 一种利用反胶束分离分析化妆品中着色剂的方法 |
Non-Patent Citations (2)
Title |
---|
Determination of sunscreen agents in cosmetic products by gas chromatography and gas chromatography-mass spectrometry;KAZUO IKEDA等;《Journal of Chromatography》;19901231;第513卷;321-326 * |
气相色谱-质谱法测定化妆品中的防晒剂;李英等;《分析试验室》;20030531;第22卷(第3期);77-80 * |
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