CN108478679A - A kind of pet parasite expelling agent and preparation method thereof - Google Patents
A kind of pet parasite expelling agent and preparation method thereof Download PDFInfo
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- CN108478679A CN108478679A CN201810443293.9A CN201810443293A CN108478679A CN 108478679 A CN108478679 A CN 108478679A CN 201810443293 A CN201810443293 A CN 201810443293A CN 108478679 A CN108478679 A CN 108478679A
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Abstract
The invention discloses a kind of pet parasite expelling agent and preparation method thereof, include the raw material of following parts by weight：45 parts of 6 parts of betelnut extract, 7 parts of fruit of Rangoon creeper's extract, 5 parts of pumpkin seed powder, 30 parts of praziquantel, 4 parts of bait powder, 8 parts of chicken liver meal, 45 parts of excipient, 1 part of glidant and 50% ethyl alcohol；It is made by softwood processed, granulation, drying, whole grain and tableting process.This programme coordinates reasonable science, only have chemical drugs simply in its product, remaining is Chinese medicine, and chemical drugs are used with Chinese medicine collocation, improve therapeutic effect, chicken liver meal and bait powder are added in the product again, its palatability can be improved, meet the needs of dog cat is to taste, to ensure dosage, the utilization rate for improving drug, reaches therapeutic effect.
Description
Technical field
The present invention relates to veterinary drug technical fields, and in particular to a kind of pet parasite expelling agent and preparation method thereof.
Background technology
The raising pets such as dog cat suffer from long history in China or even other states.With carrying for people's living standard
Height, rare dog, cat pet feeding quantity gradually increase, many families treat pet as family's a member, pet master
People also increasingly payes attention to the quality of life of pet.Endoparasite is the common disease of dog cat, few in number currently on the market
Anthelmintic is based on chemical drug or kinds of traditional Chinese medicines in pet body, and this kind of medicine toxic side effect is bigger and palatability is poor, causes dog
Cat will not actively take medicine.
Invention content
For deficiency in the prior art, the present invention provides pest repellant in a kind of pet body and preparation method thereof, the drives
Worm agent toxic side effect is small, and palatability is good and anthelminthic effect is notable.
To achieve the above object, the technical solution adopted by the present invention to solve the technical problems is：A kind of pet parasite expelling agent,
Raw material including following parts by weight is made：5-10 parts of betelnut extract, 5-8 parts of fruit of Rangoon creeper's extract, 3-5 parts of pumpkin seed powder, pyrrole
25-45 parts of quinoline ketone, 3-5 parts of bait powder, 5-10 parts of chicken liver meal, 30-50 parts of excipient, 0.5-1.5 parts of glidant and 50% ethyl alcohol
35-50 parts.
Further, a kind of pet parasite expelling agent, including the raw material of following parts by weight are made：Include the raw material of following parts by weight
It is made：6 parts of betelnut extract, 7 parts of fruit of Rangoon creeper's extract, 5 parts of pumpkin seed powder, 30 parts of praziquantel, 4 parts of bait powder, chicken liver meal 8
45 parts of part, 45 parts of excipient, 1 part of glidant and 50% ethyl alcohol.
Further, bait powder includes the raw material of following parts by weight：2 parts of chicken essence, 2 parts of duck meat essence, mutton flavor 1
Part, 1 part of fish meat flavor, 2 parts of chicken fat, 1 part of duck oil, 4 parts of sweet potato powder, 3 parts of carrot meal, 2 parts of sugar beet powder, 3 parts of salt and Catergen
Part.
Further, betelnut extract is prepared by the following method to obtain：Betel nut is crushed, 20 mesh sieve is crossed, obtains powder, to
75% ethyl alcohol of 9 times of powder weights is added in powder, impregnates 2h, is then ultrasonically treated 30 minutes, then refluxing extraction 2h, filtering,
Obtain the first extracting solution and the first filter residue；75% alcohol reflux that 6 times of first filter residue weight is added into the first filter residue extracts 1.5h,
Filtering obtains the second extracting solution, merges extracting solution twice, takes out, crushes after being placed in 100 DEG C of vacuum microwave driers dry 2h,
It sieves with 100 mesh sieve, is made.
Further, fruit of Rangoon creeper's extract is prepared by the following method to obtain：The fruit of Rangoon creeper is crushed, 20 mesh sieve is crossed, obtains powder
75% ethyl alcohol of 9 times of powder weights is added into powder for end, and it is 8.0-8.5 to be used in combination sodium carbonate to adjust pH value, then impregnates 2h,
Refluxing extraction 2h obtains the first extracting solution and the first filter residue；75% ethyl alcohol of 6 times of first filter residue weight is added into the first filter residue,
Refluxing extraction 1.5h obtains the second extracting solution；Merge extracting solution twice, is taken after being placed in 100 DEG C of vacuum microwave driers dry 2h
Go out, crush, sieve with 100 mesh sieve, is made.
Further, pumpkin seed powder is prepared by the following method to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries
It to flavescence, is shoveled out, is cooled to room temperature, finally crushed and sieve with 100 mesh sieve, be made.
Further, excipient is dextrin, and glidant is magnesium stearate.
Further, the preparation method of pet parasite expelling agent is as follows：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, is mixed
It is even, pour into 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate, mixing, with 18 mesh will be added in particle obtained by step (3)
Sieve whole grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
A kind of pet parasite expelling agent provided by the invention and preparation method thereof, has the advantages that：
1, betel nut is effective anthelmintic in Chinese medicine, and contained arecaline is the main component of expelling parasite, and anthelmintic action is very strong, energy
Tapeworm nervous system is benumbed, makes tapeworm body relaxation elongation and displaces full worm, it is also effective to roundworm and blood fluke etc., to blood fluke
Infected with certain preventive effect；When being extracted to betel nut, advanced horizontal high voltage processing, then refluxing extraction is carried out, Bin can be made
Active ingredient in bulky is fully extracted.
2, the fruit of Rangoon creeper is apt to ascarifuge and pinworm, especially kind ascarifuge, and can inhibit dermatophyte.Fruit of Rangoon creeper's extract taste is micro-
Sweet tea, pet not will produce it conflict.Roundworm disease, enterobiasis etc. are treated with the fruit of Rangoon creeper, it is significant in efficacy.The fruit of Rangoon creeper matches with betel nut
It closes and uses：Fruit of Rangoon creeper's disperse accumulation invigorating the spleen desinsection, betel nut desinsection sending down abnormally ascending row is stagnant, and two medicines share, and mutual reinforcement between pairing plays synergistic effect, from
And reinforce the desinsection efficacy of a drug, and energy gas consumption product, abdominal pain due to enterositosis can be controlled, is fainted inverse；When being extracted to the fruit of Rangoon creeper, to its ethanol solution
Solution is adjusted to alkalinity, the acid active ingredient in the fruit of Rangoon creeper is made to be more easy to dissolve out, enhances extraction efficiency by middle addition sodium carbonate.
3, pumpkin seed powder has apparent anthelmintic action to tapeworm, bow roundworm etc., has synergistic effect with arecaline, makes anthelminthic effect
Significantly.
4, praziquantel is the anti-tapeworm of comparatively ideal New-type wide-spectrum and schistosomicide, and blood fluke can be made in host to liver
It is mobile and dead in hepatic tissue.In addition, having good effect to most of tapeworm adults and prematurity polypide.In addition, to zootoxin
Property is minimum, is comparatively ideal anti-parasite medicine.Praziquantel is chemical anthelmintic, with the Chinese medicines such as betel nut, the fruit of Rangoon creeper, pumpkin seed powder
It is used cooperatively, anthelminthic effect can be greatly enhanced, reduce toxic side effect.
5, bait powder is designed exclusively for dog cat, meets the taste demand of dog cat, can be increased the palatability of food, be promoted dog cat
Appetite, the nutriment based on bait powder is without any side effects to pet.
6, chicken liver meal can also increase the palatability of food, promote dog cat food and be intended to, in chicken gizzard containing abundant protein, calcium,
Phosphorus, iron, zinc, vitamin A, B family vitamin, expelling parasite while, can supplement the trace element in dog cat body.
7, bait powder, chicken liver meal and anthelmintic collocation use, and can increase the palatability of the pest repellant, dog cat is made actively to eat
Food, can accurately control the dosage of dog cat edible medicine, achieve the purpose that remove dog cat endoparasite, effectively raise disease
Cure rate, reduce the waste of drug.
8, with adhesive effect while dextrin is as filler, keep pellet hardness obtained suitable, tablet obtained is not
Easy discrete piece.Magnesium stearate is common lubricant, has good adhesion, is evenly distributed and is not readily separated after being mixed with particle.
Specific implementation mode
Embodiment 1
A kind of pet parasite expelling agent, including the raw material of following parts by weight are made：5 parts of betelnut extract, fruit of Rangoon creeper's extract 5
Part, 3 parts of pumpkin seed powder, 25 parts of praziquantel, 3 parts of bait powder, 5 parts of chicken liver meal, 30 parts of dextrin, 0.5 part of magnesium stearate and 50% second
35 parts of alcohol.
Wherein, betelnut extract is prepared by the following method to obtain：Betel nut is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, impregnates 1h, is then ultrasonically treated 30 minutes, then refluxing extraction 1h, filtering, obtains the
One extracting solution and the first filter residue；75% alcohol reflux that 6 times of first filter residue weight is added into the first filter residue extracts 1h, filters,
The second extracting solution is obtained, extracting solution twice is merged, takes out, crushes after being placed in 100 DEG C of vacuum microwave driers dry 2h, cross 100
Mesh sieves, and is made.
Fruit of Rangoon creeper's extract is prepared by the following method to obtain：Fruit of Rangoon creeper's extract is prepared by the following method to obtain：It will
The fruit of Rangoon creeper crushes, and crosses 20 mesh sieve, obtains powder, 75% ethyl alcohol of 9 times of powder weights is added into powder, sodium carbonate is used in combination to adjust PH
For 7.0-8.0,1h is then impregnated, refluxing extraction 1h obtains the first extracting solution and the first filter residue；6 times the are added into the first filter residue
75% ethyl alcohol of one filter residue weight, refluxing extraction 1h obtain the second extracting solution；Merge extracting solution twice, is placed in 100 DEG C of vacuum microwaves
It is taken out after dry 2h in drying machine, crushes, sieve with 100 mesh sieve, be made.
Pumpkin seed powder is prepared by the following method to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries to turning yellow, will
It is shoveled out, and is cooled to room temperature, and is finally crushed and is sieved with 100 mesh sieve, is made.
The preparation process of above-mentioned pet parasite expelling agent is as follows：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, is mixed
It is even, pour into 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate, mixing, with 18 mesh will be added in particle obtained by step (3)
Sieve whole grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
Embodiment 2
A kind of pet parasite expelling agent, including the raw material of following parts by weight are made：5 parts of betelnut extract, fruit of Rangoon creeper's extract 6
Part, 4 parts of pumpkin seed powder, 27 parts of praziquantel, 4 parts of bait powder, 7 parts of chicken liver meal, 35 parts of dextrin, 0.5 part of magnesium stearate and 50% second
40 parts of alcohol.
Wherein, betelnut extract is prepared by the following method to obtain：Betel nut is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, impregnates 1.5h, is then ultrasonically treated 30 minutes, then refluxing extraction 1.5h, filtering,
Obtain the first extracting solution and the first filter residue；75% alcohol reflux that 6 times of first filter residue weight is added into the first filter residue extracts 1h, mistake
Filter obtains the second extracting solution, merges extracting solution twice, takes out, crushes, mistake after being placed in 100 DEG C of vacuum microwave driers dry 2h
100 mesh sieve, and are made.
Fruit of Rangoon creeper's extract is prepared by the following method to obtain：The fruit of Rangoon creeper is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, it is 7.0-8.0 to be used in combination sodium carbonate to adjust pH value, then impregnates 1.5h, refluxing extraction
1.5h obtains the first extracting solution and the first filter residue；75% ethyl alcohol of 6 times of first filter residue weight is added into the first filter residue, reflux carries
1.5h is taken, the second extracting solution is obtained；Merge extracting solution twice, is taken out after being placed in 100 DEG C of vacuum microwave driers dry 2h, powder
It is broken, it sieves with 100 mesh sieve, is made.
Pumpkin seed powder is prepared by the following method to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries to turning yellow, will
It is shoveled out, and is cooled to room temperature, and is finally crushed and is sieved with 100 mesh sieve, is made.
The preparation process of above-mentioned pet parasite expelling agent is as follows：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, is mixed
It is even, pour into 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate, mixing, with 18 mesh will be added in particle obtained by step (3)
Sieve whole grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
Embodiment 3
A kind of pet parasite expelling agent, including the raw material of following parts by weight are made：6 parts of betelnut extract, fruit of Rangoon creeper's extract 7
Part, 5 parts of pumpkin seed powder, 30 parts of praziquantel, 4 parts of bait powder, 8 parts of chicken liver meal, 45 parts of dextrin, 1 part of magnesium stearate and 50% ethyl alcohol
45 parts.
Wherein, betelnut extract is prepared by the following method to obtain：Betel nut is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, impregnates 2h, is then ultrasonically treated 30 minutes, then refluxing extraction 3h, filtering, obtains the
One extracting solution and the first filter residue；75% alcohol reflux that 6 times of first filter residue weight is added into the first filter residue extracts 1.5h, mistake
Filter obtains the second extracting solution, merges extracting solution twice, takes out, crushes, mistake after being placed in 100 DEG C of vacuum microwave driers dry 2h
100 mesh sieve, and are made.
Fruit of Rangoon creeper's extract is prepared by the following method to obtain：The fruit of Rangoon creeper is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, it is 8.0-8.5 to be used in combination sodium carbonate to adjust pH value, then impregnates 82h, refluxing extraction
3h obtains the first extracting solution and the first filter residue；75% ethyl alcohol of 6 times of first filter residue weight, refluxing extraction are added into the first filter residue
1.5h obtains the second extracting solution；Merge extracting solution twice, take out, crush after being placed in 100 DEG C of vacuum microwave driers dry 2h,
It sieves with 100 mesh sieve, is made.
Pumpkin seed powder is prepared by the following method to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries to turning yellow, will
It is shoveled out, and is cooled to room temperature, and is finally crushed and is sieved with 100 mesh sieve, is made.
The preparation process of above-mentioned pet parasite expelling agent is as follows：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, is mixed
It is even, pour into 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate, mixing, with 18 mesh will be added in particle obtained by step (3)
Sieve whole grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
Embodiment 4
A kind of pet parasite expelling agent, including the raw material of following parts by weight are made：8 parts of betelnut extract, fruit of Rangoon creeper's extract 7
Part, 3 parts of pumpkin seed powder, 45 parts of praziquantel, 5 parts of bait powder, 10 parts of chicken liver meal, 50 parts of dextrin, 1.5 parts of magnesium stearate and 50% second
45 parts of alcohol.
Wherein, betelnut extract is prepared by the following method to obtain：Betel nut is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, impregnates 2h, is then ultrasonically treated 30 minutes, then refluxing extraction 2h, filtering, obtains the
One extracting solution and the first filter residue；75% alcohol reflux that 6 times of first filter residue weight is added into the first filter residue extracts 1h, filters,
The second extracting solution is obtained, extracting solution twice is merged, takes out, crushes after being placed in 100 DEG C of vacuum microwave driers dry 2h, cross 100
Mesh sieves, and is made.
Fruit of Rangoon creeper's extract is prepared by the following method to obtain：The fruit of Rangoon creeper is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, it is 8.0-8.5 to be used in combination sodium carbonate to adjust pH value, then impregnates 2h, refluxing extraction
1.5h obtains the first extracting solution and the first filter residue；75% ethyl alcohol of 6 times of first filter residue weight is added into the first filter residue, reflux carries
1h is taken, the second extracting solution is obtained；Merge extracting solution twice, take out, crush after being placed in 100 DEG C of vacuum microwave driers dry 2h,
It sieves with 100 mesh sieve, is made.
Pumpkin seed powder is prepared by the following method to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries to turning yellow, will
It is shoveled out, and is cooled to room temperature, and is finally crushed and is sieved with 100 mesh sieve, is made.
The preparation process of above-mentioned pet parasite expelling agent is as follows：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, is mixed
It is even, pour into 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate, mixing, with 18 mesh will be added in particle obtained by step (3)
Sieve whole grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
Comparative example 1
A kind of pet parasite expelling agent, including the raw material of following parts by weight are made：6 parts of betelnut extract, 5 parts of pumpkin seed powder, pyrrole
45 parts of 30 parts of quinoline ketone, 4 parts of bait powder, 8 parts of chicken liver meal, 45 parts of dextrin, 1 part of magnesium stearate and 50% ethyl alcohol.
Wherein, betelnut extract is prepared by the following method to obtain：Betel nut is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, impregnates 1.5h, is then ultrasonically treated 30 minutes, then refluxing extraction 1.5h, filtering,
Obtain the first extracting solution and the first filter residue；75% alcohol reflux that 6 times of first filter residue weight is added into the first filter residue extracts 1h, mistake
Filter obtains the second extracting solution, merges extracting solution twice, takes out, crushes, mistake after being placed in 100 DEG C of vacuum microwave driers dry 2h
100 mesh sieve, and are made.
Fruit of Rangoon creeper's extract is prepared by the following method to obtain：The fruit of Rangoon creeper is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, it is 6.0-7.0 to be used in combination sodium carbonate to adjust pH value, then impregnates 1.5h, refluxing extraction
1.5h obtains the first extracting solution and the first filter residue；75% ethyl alcohol of 6 times of first filter residue weight is added into the first filter residue, reflux carries
1.5h is taken, the second extracting solution is obtained；Merge extracting solution twice, is taken out after being placed in 100 DEG C of vacuum microwave driers dry 2h, powder
It is broken, it sieves with 100 mesh sieve, is made.
Pumpkin seed powder is prepared by the following method to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries to turning yellow, will
It is shoveled out, and is cooled to room temperature, and is finally crushed and is sieved with 100 mesh sieve, is made.
The preparation process of above-mentioned pet parasite expelling agent is as follows：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, is mixed
It is even, pour into 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate, mixing, with 18 mesh will be added in particle obtained by step (3)
Sieve whole grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
Comparative example 2
A kind of pet parasite expelling agent, including the raw material of following parts by weight are made：6 parts of betelnut extract, fruit of Rangoon creeper's extract 7
45 parts of part, 4 parts of bait powder, 8 parts of chicken liver meal, 45 parts of dextrin, 1 part of magnesium stearate and 50% ethyl alcohol.
Wherein, betelnut extract is prepared by the following method to obtain：Betel nut is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, impregnates 2h, is then ultrasonically treated 30 minutes, then refluxing extraction 2h, filtering, obtains the
One extracting solution and the first filter residue；75% alcohol reflux that 6 times of first filter residue weight is added into the first filter residue extracts 1.5h, mistake
Filter obtains the second extracting solution, merges extracting solution twice, takes out, crushes, mistake after being placed in 100 DEG C of vacuum microwave driers dry 2h
100 mesh sieve, and are made.
Fruit of Rangoon creeper's extract is prepared by the following method to obtain：The fruit of Rangoon creeper is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, it is 7.0-8.5 to be used in combination sodium carbonate to adjust pH value, then impregnates 2h, refluxing extraction
1.5h obtains the first extracting solution and the first filter residue；75% ethyl alcohol of 6 times of first filter residue weight is added into the first filter residue, reflux carries
2h is taken, the second extracting solution is obtained；Merge extracting solution twice, take out, crush after being placed in 100 DEG C of vacuum microwave driers dry 2h,
It sieves with 100 mesh sieve, is made.
Pumpkin seed powder is prepared by the following method to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries to turning yellow, will
It is shoveled out, and is cooled to room temperature, and is finally crushed and is sieved with 100 mesh sieve, is made.
The preparation process of above-mentioned pet parasite expelling agent is as follows：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, is mixed
It is even, pour into 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate, mixing, with 18 mesh will be added in particle obtained by step (3)
Sieve whole grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
Comparative example 3
A kind of pet parasite expelling agent, including the raw material of following parts by weight are made：6 parts of betelnut extract, lures at 5 parts of pumpkin seed powder
45 parts of 4 parts of baking soda, 8 parts of chicken liver meal, 45 parts of dextrin, 1 part of magnesium stearate and 50% ethyl alcohol.
Wherein, betelnut extract is prepared by the following method to obtain：Betel nut is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, impregnates 2h, is then ultrasonically treated 30 minutes, then refluxing extraction 2h, filtering, obtains the
One extracting solution and the first filter residue；75% alcohol reflux that 6 times of first filter residue weight is added into the first filter residue extracts 1.5h, mistake
Filter obtains the second extracting solution, merges extracting solution twice, takes out, crushes, mistake after being placed in 100 DEG C of vacuum microwave driers dry 2h
100 mesh sieve, and are made.
Fruit of Rangoon creeper's extract is prepared by the following method to obtain：The fruit of Rangoon creeper is crushed, 20 mesh sieve is crossed, powder is obtained, to powder
Middle 75% ethyl alcohol that 9 times of powder weights are added, it is 7.0-8.5 to be used in combination sodium carbonate to adjust pH value, then impregnates 2h, refluxing extraction
2h obtains the first extracting solution and the first filter residue；75% ethyl alcohol of 6 times of first filter residue weight, refluxing extraction are added into the first filter residue
1.5h obtaining the second extracting solution；Merge extracting solution twice, take out, crush after being placed in 100 DEG C of vacuum microwave driers dry 2h,
It sieves with 100 mesh sieve, is made.
Pumpkin seed powder is prepared by the following method to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries to turning yellow, will
It is shoveled out, and is cooled to room temperature, and is finally crushed and is sieved with 100 mesh sieve, is made.
The preparation process of above-mentioned pet parasite expelling agent is as follows：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, is mixed
It is even, pour into 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate, mixing, with 18 mesh will be added in particle obtained by step (3)
Sieve whole grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
Ingredient ratio is shown in Table 1 in each embodiment.
Table 1：
Test example
Bait powder and chicken liver meal are added in this product, palatability is good, can meet the needs of dog cat is to taste, makes dog cat
The pest repellant that can actively eat food improves the utilization rate of drug, reaches therapeutic effect to ensure dosage.
140 dog cats for suffering from parasite are randomly selected, 7 groups is randomly divided into, every group 20, this 7 groups of dog cats is divided
Other feeding before then detecting use, using 7 days and uses 15 days according to the product obtained by embodiment 1-4 and comparative example 1-3
When, the number of parasitic ovum in every group of dog cat excrement, and being counted, for details see attached table 2；Follow-up observation dog cat uses drug simultaneously
Situation afterwards, and to according to made from embodiment 1-4 and comparative example 1-3 pest repellant carry out physical and chemical inspection, respectively from disintegration time limited,
Tablet appearance, whether there is or not sliver, food situation, therapeutic effect and general statuses etc. to score, and marking mode is hundred-mark system,
The average value of scoring is shown in Table 3 as appraisal result, appraisal result.
Table 2：
| Before use | It uses 7 days | It uses 15 days | |
| First group：Embodiment 1 (a) | 23 | 5 | 2 |
| Second group：Embodiment 2 (a) | 26 | 6 | 1 |
| Third group：Embodiment 3 (a) | 25 | 3 | 0 |
| 4th group：Embodiment 4 (a) | 23 | 5 | 1 |
| 5th group：Comparative example 1 (a) | 26 | 9 | 4 |
| 6th group：Comparative example 2 (a) | 24 | 8 | 4 |
| 7th group：Comparative example 3 (a) | 23 | 11 | 5 |
Table 3：
It is learnt by embodiment 1-4, comparative example 1-3 and experimental example, is produced according to technological parameter provided by the invention
Product can arrive in terms of disintegration time limited, visual condition, whether there is or not sliver, food situation, therapeutic effect and general status to one
Determine therapeutic effect, the performance that products obtained therefrom various aspects are especially produced according to the technological parameter of embodiment 3 is best.
Claims (8)
1. a kind of pet parasite expelling agent, which is characterized in that include the raw material of following parts by weight：5-10 parts of betelnut extract, the fruit of Rangoon creeper
5-8 parts of extract, 3-5 parts of pumpkin seed powder, 25-45 parts of praziquantel, 3-5 parts of bait powder, 5-10 parts of chicken liver meal, excipient 30-50
35-50 parts of part, 0.5-1.5 parts of glidant and 50% ethyl alcohol.
2. pet parasite expelling agent according to claim 1, which is characterized in that include the raw material of following parts by weight：Betel nut extracts
6 parts of object, 7 parts of fruit of Rangoon creeper's extract, 5 parts of pumpkin seed powder, 30 parts of praziquantel, 4 parts of bait powder, 8 parts of chicken liver meal, 45 parts of excipient,
45 parts of 1 part of glidant and 50% ethyl alcohol.
3. pet parasite expelling agent according to claim 1 or 2, which is characterized in that the bait powder includes following parts by weight
Raw material：2 parts of chicken essence, 2 parts of duck meat essence, 1 part of mutton flavor, 1 part of fish meat flavor, 2 parts of chicken fat, 1 part of duck oil, sweet potato powder 4
Part, 3 parts of carrot meal, 2 parts of sugar beet powder, 3 parts of salt and Catergen part.
4. pet parasite expelling agent according to claim 1 or 2, which is characterized in that the betelnut extract is by the following method
It is prepared：Betel nut is crushed, 20 mesh sieve is crossed, obtains powder, 75% ethyl alcohol of 9 times of powder weights is added into powder, impregnate 1-
Then 2h is ultrasonically treated 30 minutes, then refluxing extraction 1-3h, and filtering obtains the first extracting solution and the first filter residue；Into the first filter residue
75% alcohol reflux that 6 times of first filter residue weight is added extracts 1-2h, and filtering obtains the second extracting solution, merges extracting solution twice, sets
It is taken out after dry 2h in 100 DEG C of vacuum microwave driers, crushes, sieve with 100 mesh sieve, be made.
5. pet parasite expelling agent according to claim 1 or 2, which is characterized in that fruit of Rangoon creeper's extract passes through with lower section
Method is prepared：The fruit of Rangoon creeper is crushed, 20 mesh sieve is crossed, obtains powder, 75% ethyl alcohol of 9 times of powder weights is added into powder, and
It is 7.0-8.5 to adjust pH value with sodium carbonate, then impregnates 1-2h, refluxing extraction 1-3h obtains the first extracting solution and the first filter residue；To
75% ethyl alcohol of 6 times of first filter residue weight is added in first filter residue, refluxing extraction 1-2h obtains the second extracting solution；Merging carries twice
Liquid is taken, is taken out after being placed in 100 DEG C of vacuum microwave driers dry 2h, crushes, sieve with 100 mesh sieve, be made.
6. pet parasite expelling agent according to claim 1 or 2, which is characterized in that the pumpkin seed powder is made by the following method
It is standby to obtain：Pumpkin seeds are put in pot, small fire does not stop to stir-fry, and fries to turning yellow, is shoveled out, be cooled to room temperature, finally crushed 100
Mesh sieves, and is made.
7. pet parasite expelling agent according to claim 1 or 2, which is characterized in that the excipient is dextrin, the glidant
For magnesium stearate.
8. according to the preparation method of claim 1-7 any one of them pet parasite expelling agent, which is characterized in that including following step
Suddenly：
(1) softwood processed：Betelnut extract, fruit of Rangoon creeper's extract, pumpkin seed powder, dextrin and praziquantel are weighed by formula, mixing,
Enter 50% ethyl alcohol, softwood processed；
(2) it pelletizes：Softwood obtained by step (1) is put into oscillating granulator and is pelletized, sieve mesh number is 16 mesh；
(3) dry：Particle obtained by step (2) is dried at 100 DEG C, moisture control is in 2%-6% after drying；
(4) whole grain：Bait powder, chicken liver meal and magnesium stearate will be added in particle obtained by step (3), mixing is sieved whole with 18 mesh
Grain；
(5) tabletting：Tabletting will be carried out in step (4) products obtained therefrom input tablet press machine.
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| CN111202164A (en) * | 2019-06-13 | 2020-05-29 | 杭州海渤源生物科技有限公司 | Insect-expelling compound soft capsule for pets and preparation method thereof |
| CN112450321A (en) * | 2020-12-14 | 2021-03-09 | 青岛王牌动物健康产品有限公司 | Preparation method of insect-expelling soft spindle for plants |
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| CN111202164B (en) * | 2019-06-13 | 2023-10-13 | 杭州海渤源生物科技有限公司 | Pet insect-repellent composite soft capsule and preparation method thereof |
| CN110419492A (en) * | 2019-07-12 | 2019-11-08 | 湖南省中医药研究院 | It is a kind of to establish the method for building up that oral mucosa fibroid becomes animal model using betelnut extract and mechanical friction |
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