CN108452258A - It is a kind of to treat anginal drug and preparation method thereof - Google Patents

It is a kind of to treat anginal drug and preparation method thereof Download PDF

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Publication number
CN108452258A
CN108452258A CN201810470997.5A CN201810470997A CN108452258A CN 108452258 A CN108452258 A CN 108452258A CN 201810470997 A CN201810470997 A CN 201810470997A CN 108452258 A CN108452258 A CN 108452258A
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grams
radix
impurity
picked
water
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蒋勇
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

Anginal drug and preparation method thereof is treated the invention discloses a kind of, is mainly prepared according to a certain weight ratio by cape jasmine, Snakegourd Fruit, radix polygonati officinalis, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, the membrane of a chicken's gizzard, corydalis tuber, Rhizoma Chuanxiong, purslane, Radix Curcumae, peach kernel, Fructus Aurantii, cassia twig, dragon's blood, spina date seed, lepidium seed, motherwort, galangal, the tuber of pinellia, Ramulus Taxilli, radix paeoniae rubra, Cortex Eucommiae, hawthorn, excrementum pteropi.Drug of the present invention has a blood circulation and promoting silt, calming heart and tranquilizing mind, clearing away heat and eliminating phlegm, promote breath and open depression, the function of eliminating dampness, and angina pectoris is quick, good effect for treating, and does not recur.

Description

It is a kind of to treat anginal drug and preparation method thereof
Technical field
Anginal drug and preparation method thereof is treated the present invention relates to a kind of, belongs to the field of Chinese medicines.
Technical background
Angina pectoris is coronary insufficiency, caused by cardiac muscle ischemia drastically and anoxic with ictal pectoralgia Or chest discomfort is the clinical syndrome mainly showed.Chinese medicine then thinks angina pectoris and qi depression to blood stasis, essential resistance of turbid phlegm, attacked by the cold and evil It is related.Since western medicine side effect is big, there are great demands to effectively treating anginal Chinese medicine by people, until Until the present, it has not been found that the related report about the present invention.
Invention content
Repeatedly verification of the present inventor according to research and the clinical test of theory of traditional Chinese medical science has finally found the effectively treatment heart and twists The drug of pain, so as to complete the present invention.
It is an object of the invention to provide one kind effectively treating anginal Chinese medicine composition.
Another aim of the present invention is to provide the preparation methods of the Chinese medicine composition.
The present invention be selection cape jasmine, Snakegourd Fruit, radix polygonati officinalis, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, the membrane of a chicken's gizzard, corydalis tuber, Rhizoma Chuanxiong, purslane, Radix Curcumae, Peach kernel, Fructus Aurantii, cassia twig, dragon's blood, spina date seed, lepidium seed, motherwort, galangal, the tuber of pinellia, Ramulus Taxilli, radix paeoniae rubra, Cortex Eucommiae, hawthorn, five Clever fat, frankincense, myrrh, Radix Glycyrrhizae, cortex albiziae, Cortex Magnoliae Officinalis, citron drug are combined preparation, these pharmaceutical compositions are made each medicine Object effect generates synergistic effect, so as to effectively treat angina pectoris.Wherein, selecting cape jasmine is trembled with fear, enters because its is bitter in taste The heart, liver, lung, stomach have heat-clearing, purging intense heat, the function of cool blood to control pyreticosis restlessness of asrhenia type and insomnia, jaundice, and gonorrhoea is quenched one's thirst, hot eyes, pharyngalgia, It spits blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, pathopyretic ulcer, strain swelling and pain.Selecting Snakegourd Fruit is trembled with fear because its nature and flavor is sweet, slight bitter, return lung, stomach, Large intestine channel has clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, the function of moisturize laxation to control cough with lung heat, and the turbid Huang of phlegm is thick, chest impediment and cardialgia, accumulation of pathogens in chest ruffian It is full, acute mastitis, acute appendicitis, constipation.It is to enter lung, stomach has yin-nourishing, moisturizes, relieving restlessness, only because of its nature and flavor sweet and neutral to select radix polygonati officinalis Thirsty function controls pyreticosis sun wound, and cough, polydipsia, deficient fever, the paddy that disappears is easily hungry, frequent urination.It is because of its nature and flavor to select Radix Salviae Miltiorrhizae Hardship, tepor enter the heart, Liver Channel, there is a blood circulation and promoting silt, calming heart and tranquilizing mind, apocenosis, the function of analgesic, control angina pectoris, irregular menstruation, dysmenorrhoea, To close, metrorrhagia band Xia , Disorder lumps in the abdomen, accumulation, abdominal pain due to blood stasis, arthralgia, shock palpitation not sleep, malignant sore swollen drug.It is because of it to select Radix Ophiopogonis Property sweet and slightly bitter taste, tremble with fear, enter lung, stomach, the heart channel of Hang-Shaoyin, there is Yin nourishing and lung moistening, relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits Blood, spitting of blood, consumptive lung disease, lung carbuncle, consumptive disease dysphoria with smothery sensation is clear thirsty, pyreticosis Tianjin wound, dry throat, constipation.It is because of its nature and flavor to select the membrane of a chicken's gizzard Sweet and neutral enters spleen, stomach, removes food retention, the function of strengthening the spleen and stomach, controls dyspepsia turgor, vomiting gastric disorder causing nausea, rush down dysentery, and infantile malnutrition due to digestive disturbances or intestinalparasites is quenched one's thirst, and loses It drowns, larynx numbness acute tonsillitis, noma aphtha.It is because its nature and flavor is arduous to select corydalis tuber, and temperature enters liver, stomach, there is promoting blood circulation, dissipates the stasis of blood, reason Gas, the function of analgesic control all pains of trusted subordinate's waist and knee, irregular menstruation , Disorder lumps in the abdomen, metrorrhagia, postpartum anemic fainting, lochiorrhagia, traumatic injury.Choosing It is to enter liver, gallbladder channel because its nature and flavor is acrid in flavour and warm in nature, there is promote breath and open depression, dispel pathogenic wind and remove dampness, the function of promoting blood circulation and stopping pain controls air-cooled head with Rhizoma Chuanxiong Pain revolves dizzy, hypochondriac pain abdomen pain, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores.It is because of its property to select purslane It is sour, it trembles with fear, enters large intestine, liver, the spleen channel, have clearing heat and detoxicating, dissipate the function of blood detumescence, control hot dysentery purulence blood, heat gonorrhea, blood strangury, under band, carbuncle Swollen malignant sore, erysipelas, scrofula.Selecting Radix Curcumae is worked hard because of its nature and flavor, cool, enters the heart, lung, Liver Channel, has promoting the circulation of qi solution with cool blood broken stasis of blood Function, control all pains of chest and abdomen side of body rib, insane, pyreticosis coma is spitted blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, women's vicarious menstruation, jaundice.Choosing It is to enter the heart, liver, large intestine channel because of its sweet and neutral bitter in taste, there is the blood-breaking row stasis of blood with peach kernel, moisturizes the function of sliding warp, controlling through closing , Disorder Lump in the abdomen, pyreticosis store blood, blood-arthralgia, malaria, traumatic injury, blood stasis and swelling pain, the dry constipation of blood.Select Fructus Aurantii be because of its nature and flavor toil, it is cool, Entering lung, spleen, large intestine channel, there is a relieving stagnant Qi, row phlegm, the function of disperse accumulation controls that chest diaphragm phlegm is stagnant, and the feeling of stuffiness in chest coerces swollen, dyspepsia, and gas is vomitted inverse, under Weight, rectal prolapse, the prolapse of uterus after dysentery.It is to enter bladder, the heart, lung channel because of the pungent sweet, warm of its nature and flavor, there is sweating expelling pathogenic factors from muscles and skin to select cassia twig, temperature Function through promoting blood circulation, controls exterior syndrome due to wind-cold, and shoulder carries on the back podomere ache, obstruction of qi in the chest phlegm and retained fluid, Jing Bi Disorder lumps in the abdomen.It is because its nature and flavor is sweet to select dragon's blood It is salty, it puts down, enters the heart, Liver Channel, there is scattered stasis pain, the function of hemostasia and promoting granulation to control traumatic injury, internal injury stasis caused pain, traumatic hemorrhage is more than, scrofula Scrofula, ulcer on the shank is burst not to be conformed to long.It is to enter the heart, spleen, liver, gallbladder channel because of its nature and flavor sweet and neutral to select spina date seed, has nourishing the liver, calming heart to calm the nerves, The function of arrest sweating controls restlessness of asrhenia type and insomnia, palpitation of palpitating with fear, polydipsia, abnormal sweating.It is because its nature and flavor is pungent to select lepidium seed, and bitter, Great Cold returns Lung, bladder warp, there is a removing heat from lung and relieving asthma, the function of inducing diuresis for removing edema, control sputum stop up lung, cough and phlegm, fullness in chest and hypochondrium, and chest and abdomen oedema is small Just unfavorable and cor pulmonale oedema.Selecting motherwort is worked hard because of its nature and flavor, cool, enters pericardium, Liver Channel, there is promoting blood circulation, dispels The stasis of blood, menstruation regulating, the function for the water that disappears control irregular menstruation, control leakage difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, urine Blood rushes down blood, carbuncle swells sore.It is to enter spleen because of its property and flavor of peppery and warm to select galangal, stomach, there is a warm stomach, wind-dispelling, cold dispelling, promoting the circulation of qi, The function of analgesic controls taste syncope due to pathogenic cold, coldness and pain in the epigastrium, vomiting and diarrhea, dysphagia and regurgitation, food stagnation, malignant malaria, cold addiction.Select the tuber of pinellia be because It is acrid in flavour and warm in nature for its nature and flavor, it is toxic, enter spleen, stomach, there is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass to control wet phlegm and cold drink, vomit It spits, gastric disorder causing nausea, cough and phlegm, fullness in chest, phlegm and headache, dizziness and sleepless, outer subduing inflammation.It is because its is bitter in taste to select Ramulus Taxilli Sweet and neutral enters liver and kidney channel, there is a filling liver kidney, strengthening the bones and muscles, curing rheumatism, degrading the channel, beneficial blood, and the function of tocolysis controls soreness of waist and knee joint, muscles and bones Impotence is weak, hemiplegia, tinea pedis, wind-cold-dampness arthralgia, threatened abortion metrorrhagia, lack of lactation after delivery.Selecting radix paeoniae rubra is slightly cold, returns because its is bitter in taste Liver Channel has clearing heat and cooling blood, the function of removing blood stasis and analgesics to control epidemic heat syndrome and go mad, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, Amenorrhea pain Jing , Epilepsy lump in the abdomen abdominal pain, injury from falling down, carbuncle swells sore.It is to enter liver and kidney channel because its nature and flavor is sweet micro- acrid in flavour and warm in nature, there is tonifying liver to select Cortex Eucommiae Kidney, strengthening the bones and muscles, the function of tocolysis control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination, and threatened abortion is intended to fall, hypertension.Choosing It is because its nature and flavor acid is sweet with hawthorn, tepor enters spleen, stomach, Liver Channel, has digestion gathered food, scattered blood stasis, taenifugal function to control meat product, Disorder lumps in the abdomen, phlegm and retained fluid, feeling of fullness, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia, postpartum postpartum abdominal pain, lochiorrhagia, pediatric milk food stagnation.It selects Excrementum pteropi is to enter liver, the spleen channel because of its sweet, warm bitter in taste, and the raw function of having promoting circulation of blood to relieve pain controls all pains of trusted subordinate's vim and vigour, women Amenorrhea, postpartum blood stasis are had a pain；Outer to control snake, scorpion, centipde-bite, stir-fry hemostasis controls metrorrhagia, menorrhagia, and leukorrhea with bloody discharge is without cease.Choosing It is because its nature and flavor is arduous with frankincense, temperature enters the heart, liver, the spleen channel, has regulating qi and activating blood, analgesic therapy, the function of chasing after poison to control qi and blood stagnation, Trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, dysmenorrhoea, postpartum blood stasis stabbing pain.It is to put down because its is bitter in taste, enter liver to select myrrh Through, there are scattered blood stasis eliminatings, the function of detumescence ding-tong to control and fall damage, metal-inflicted wound, muscles and bones, all Tong , Disorder lumps in the abdomen of trusted subordinate, Amenorrhea, ulcer sore pain, hemorrhoid Leakage, mesh barrier.It is to enter spleen, stomach, lung channel because of its sweet in flavor and neutral in nature to select Radix Glycyrrhizae, has and detoxifies with middle emergency, moistening lung, coordinating the drug actions of a prescription Function, processs, deficiency of food weakness of the spleen and the stomach with controlling, abdominal pain loose stool, overstrain fever, consumptive lung disease cough, and palpitaition shies carbuncle, life with controlling abscess of throat, Peptic ulcer, ulcer sores, antidote poison and food poisoning.It is to enter the heart, Liver Channel because of its nature and flavor sweet and neutral, have to select cortex albiziae Xie Yu and blood, calming heart, the function of subduing inflammation control confused and worried, melancholy insomnia, lung carbuncle, carbuncle swells, scrofula, injured bone.It selects Cortex Magnoliae Officinalis is to enter spleen, stomach, large intestine channel because its is bitter in taste acrid in flavour and warm in nature, there is a middle benefit gas, lower gas, eliminating dampness, and the function of dissolving phlegm controls chest and abdomen feeling of fullness Distending pain, gastric disorder causing nausea, vomiting, place food do not disappear, sputum cough, cold-dampness rush down dysentery.Select citron and be because of the arduous acid of its nature and flavor, temperature, enter liver, Lung, the spleen channel have qi-regulating, and Shu Yu, dissolving phlegm, the function of sharp diaphragm, treat for stomachache turgor, and phlegmatic cough's gas is stopped up, the few food of the sound of vomiting of vomitting.
Specific implementation mode
The drug dose of instant component is also to be obtained by plenty of explorations of the inventor, and the dosage of each component is following heavy All tools have a better effect in amount range：
10-15 grams of cape jasmine, 10-20 grams of Snakegourd Fruit, 10-20 grams of radix polygonati officinalis, 15-20 grams of Radix Salviae Miltiorrhizae, 10-15 grams of Radix Ophiopogonis, the membrane of a chicken's gizzard 10-15 Gram, 10-20 grams of corydalis tuber, 5-15 grams of Rhizoma Chuanxiong, 5-15 grams of purslane, 5-10 grams of Radix Curcumae, 10-15 grams of peach kernel, 10-20 grams of Fructus Aurantii, 17-21 grams of cassia twig, 5-10 grams of dragon's blood, 10-15 grams of spina date seed, 5-15 grams of lepidium seed, 10-15 grams of motherwort, galangal 10-15 Gram, 3-9 grams of the tuber of pinellia, 5-10 grams of Ramulus Taxilli, 10-15 grams of radix paeoniae rubra, 10-20 grams of Cortex Eucommiae, 5-15 grams of hawthorn, 5-10 grams of excrementum pteropi, breast Fragrant 3-9 grams, 3-9 grams of myrrh, 10-15 grams of Radix Glycyrrhizae, 10-20 grams of cortex albiziae, 5-15 grams of Cortex Magnoliae Officinalis, 5-10 grams of citron.
Preferably：
12 grams of cape jasmine, 15 grams of Snakegourd Fruit, 15 grams of radix polygonati officinalis, 18 grams of Radix Salviae Miltiorrhizae, 12 grams of Radix Ophiopogonis, 12 grams of the membrane of a chicken's gizzard, 15 grams of corydalis tuber, Rhizoma Chuanxiong 10 Gram, 10 grams of purslane, 8 grams of Radix Curcumae, 12 grams of peach kernel, 15 grams of Fructus Aurantii, 19 grams of cassia twig, 8 grams of dragon's blood, 12 grams of spina date seed, lepidium seed 10 Gram, 12 grams of motherwort, 12 grams of galangal, 6 grams of the tuber of pinellia, 8 grams of Ramulus Taxilli, 12 grams of radix paeoniae rubra, 15 grams of Cortex Eucommiae, 10 grams of hawthorn, excrementum pteropi 8 Gram, 6 grams of frankincense, 6 grams of myrrh, 12 grams of Radix Glycyrrhizae, 15 grams of cortex albiziae, 10 grams of Cortex Magnoliae Officinalis, 8 grams of citron.
The preparation method of drug of the present invention is as follows
One, it stocks up
1, cape jasmine：Grey bits are weeded out, impurity is picked, pulverize sieving or cut off both ends；
2, Snakegourd Fruit：Crude drug is taken, impurity and carpopodium are removed, is cleaned, is flattened, chopping or fritter are dry；
3, radix polygonati officinalis：Impurity is removed, soil, bored profit to uniform humidity inside and outside are cleaned, slice dries；
4, Radix Salviae Miltiorrhizae：Net impurity is picked, rhizome is removed, is cleaned, is pulled out, be sliced, dry after moisturizing；
5, Radix Ophiopogonis：Net impurity is picked, is soaked in water, is pulled out, the heart is pumped after moisturizing, then clean and dry；
6, the membrane of a chicken's gizzard：Impurity is picked, rinses and dries；
7, corydalis tuber：Impurity is picked, is soaked in water, is cleaned, solarization is dried in the air, and is moistened to uniform humidity inside and outside, is sliced or broken；
8, Rhizoma Chuanxiong：Impurity is picked, large and small is separated, is soaked in water, solarization is dried in the air, and is sliced after bored profit, dry；
9, purslane：Net impurity is picked, undesirable root is removed, is slightly moistened with water, segment is dried；
10, Radix Curcumae：It is soaked in water, cleans, pull solarization out and dry in the air, moisturize, be sliced, dry；
11, peach kernel：Hard shell impurity is removed, sets in boiling water pot and boils to crust microcreping, pull out, is immersed in cold water, kind of a skin is removed in stranding, shines It is dry, it winnows with a dustpan net；
12, Fructus Aurantii：Flesh, core are removed, edulcoration is slightly soaked, pulled out, softens, and it is degree that can pinch doubling with hand, and slice dries；
13, cassia twig：It is slightly impregnated, is pulled out with water, to saturating, slice dries, weeds out bits bored profit；
14, dragon's blood：Wipe dust away, knock fritter, in winter dryness weather, being placed in lime altar makes dry, then multiplies crisp grind；
15, spina date seed：Active compound is put into bamboo basket, sinks in clear water cylinder, benevolence is made to keep afloat, and thorn benevolence is pulled out, shone by the heavy bottom of shell It is dry；
16, lepidium seed：Crude drug is taken, impurity is removed；
17, motherwort：Impurity is picked, cleans, moisturizes, segment is dried；
18, galangal：Net impurity is picked, is washed, is slightly soaked, pull out, moisturize, is sliced, dries；
19, the tuber of pinellia：Impurity is picked, grey bits are weeded out；
20, Ramulus Taxilli：It is eluted with water, moisturizes, segment is dried；
21, radix paeoniae rubra：Crude drug is taken, impurity is removed, size stepping is cleaned, moisturized, shave, dry, weeds out clast；
22, Cortex Eucommiae：Tertia is removed, cleans, moisturizes, dice or strand dry；
23, hawthorn：Net impurity is picked, core is weeded out；
24, excrementum pteropi：Net impurity is picked, grey bits are smashed or weed out；
25, frankincense：Pick sand impurity；
26, myrrh：Impurity is picked, fragment is broken into；
27, Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, moisturize, be sliced, airing；
28, cortex albiziae：Clear water, which impregnates, to be cleaned, and pulls out, equal big strip, then stripping and slicing or chopping are first divided into after bored profit, dry；
29, Cortex Magnoliae Officinalis：It is soaked in water and pulls out, tertia is scraped off after moisturizing, clean, chopping is dried；
30, citron：Crude drug is taken, removes impurity, wash quickly is net, slightly moistens, chopping, and low temperature drying weeds out clast.
Two, it prepares
1, by the cape jasmine of the weight, Snakegourd Fruit, radix polygonati officinalis, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, the membrane of a chicken's gizzard, corydalis tuber, Rhizoma Chuanxiong, purslane, Radix Curcumae, peach Benevolence, Fructus Aurantii, cassia twig, dragon's blood, spina date seed, lepidium seed, motherwort, galangal, the tuber of pinellia, Ramulus Taxilli, radix paeoniae rubra, Cortex Eucommiae, hawthorn, five spirits Fat, frankincense, myrrh, Radix Glycyrrhizae, cortex albiziae, Cortex Magnoliae Officinalis, citron are put into decocting container, add 8 times of amounts of water, after impregnating 100 minutes, intense fire Boiling is decocted, then with being cooked by slow fire 20 minutes, filters to obtain first time decoction liquor, first time decoction liquor is poured into container；
2, the dregs of a decoction of filtering are added into 6 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
3, it decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.
Radix Salviae Miltiorrhizae blood circulation and promoting silt in prescription, calming heart and tranquilizing mind, apocenosis, analgesic, Snakegourd Fruit have clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens to moisturize cunning Both functions of intestines are monarch drug in a prescription；Radix Ophiopogonis Yin nourishing and lung moistening, relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid, Rhizoma Chuanxiong have promote breath and open depression, dispel pathogenic wind and remove dampness, living The function of blood and relieving pain is ministerial drug with cape jasmine, radix polygonati officinalis, the membrane of a chicken's gizzard, corydalis tuber, and eight taste medicines play heat clearing and blood circulation promoting stasis eliminatings jointly, calm the nerves Calming heart, clearing away heat and eliminating phlegm, promote breath and open depression, relieving restlessness that clears away heart-fire, the effect of reinforcing stomach reg fluid, treatment angina pectoris effect are comprehensive and cool with heat-clearing Blood, hemostasis based on dissolving stasis, can effect a permanent cure；Spina date seed has a nourishing the liver, calming heart, calms the nerves, the function of arrest sweating and purslane, Radix Curcumae, peach kernel, Fructus Aurantii, cassia twig, dragon's blood, spina date seed, lepidium seed, motherwort, galangal, the tuber of pinellia, Ramulus Taxilli are adjutant；Cortex Magnoliae Officinalis has a middle benefit gas, lower gas, Eliminating dampness, the function of dissolving phlegm are to make medicine with remaining all medicines, are to take stopgap measures.
Drug of the present invention has blood circulation and promoting silt, calming heart and tranquilizing mind, clearing away heat and eliminating phlegm, promote breath and open depression, the function of eliminating dampness, for treating Angina pectoris, short treating period, quick, non-relapse after healing.
Carry out the advantageous effect of the present invention is further explained the drug below by way of test example, these test examples include this hair The animal toxicity test report of bright drug and clinical observation on the therapeutic effect data.
The animal toxicity test of [test example 1] drug of the present invention is reported：
Rabbit 30, male and female dual-purpose, 2.0-2.5kg of weight is taken to be divided to two groups, every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode gives for administration by gavage Medicine even served 7 days twice daily, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and drug is without bad Toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] drug of the present invention
1, general information
Accept angina pectoris out-patient totally 34 for medical treatment.
2, diagnostic criteria
Classical symptom is：After suffocating pain over the chest, squeezing property pain or breastbone, bottleneck throat girdle sensation etc..
3, therapy
Above-mentioned medicament is selected, is taken to patient, each taking 1 dose, early daily, evening respectively takes 1 time, 15 days as a treatment course, continuously It takes 2 course for the treatment of.
4, efficacy assessment standard
It is effective：Angina pectoris symptom disappears, and constitution restores normal, recovery from illness；
It improves：The bored pain of patient chest, squeezing property pain or breastbone after, bottleneck throat girdle sensation the phenomenon that mitigate, angina pectoris symptom is bright Aobvious to improve, constitution is gradually restored；
In vain：Improvement standard person is not achieved.
5, treatment results（It see the table below）
In above-mentioned treatment, with drug therapy patient with angina pectoris 34 of the present invention, as a result effective 28, obvious effective rate 82.35%, It improves 4, improvement rate 11.76%, invalid 2, total effective rate 94.11%.

Claims (3)

1. a kind for the treatment of anginal drug, it is characterised in that：It is made of the bulk pharmaceutical chemicals in following weight range：
10-15 grams of cape jasmine, 10-20 grams of Snakegourd Fruit, 10-20 grams of radix polygonati officinalis, 15-20 grams of Radix Salviae Miltiorrhizae, 10-15 grams of Radix Ophiopogonis, the membrane of a chicken's gizzard 10-15 Gram, 10-20 grams of corydalis tuber, 5-15 grams of Rhizoma Chuanxiong, 5-15 grams of purslane, 5-10 grams of Radix Curcumae, 10-15 grams of peach kernel, 10-20 grams of Fructus Aurantii, 17-21 grams of cassia twig, 5-10 grams of dragon's blood, 10-15 grams of spina date seed, 5-15 grams of lepidium seed, 10-15 grams of motherwort, galangal 10-15 Gram, 3-9 grams of the tuber of pinellia, 5-10 grams of Ramulus Taxilli, 10-15 grams of radix paeoniae rubra, 10-20 grams of Cortex Eucommiae, 5-15 grams of hawthorn, 5-10 grams of excrementum pteropi, breast Fragrant 3-9 grams, 3-9 grams of myrrh, 10-15 grams of Radix Glycyrrhizae, 10-20 grams of cortex albiziae, 5-15 grams of Cortex Magnoliae Officinalis, 5-10 grams of citron.
2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals is：
12 grams of cape jasmine, 15 grams of Snakegourd Fruit, 15 grams of radix polygonati officinalis, 18 grams of Radix Salviae Miltiorrhizae, 12 grams of Radix Ophiopogonis, 12 grams of the membrane of a chicken's gizzard, 15 grams of corydalis tuber, Rhizoma Chuanxiong 10 Gram, 10 grams of purslane, 8 grams of Radix Curcumae, 12 grams of peach kernel, 15 grams of Fructus Aurantii, 19 grams of cassia twig, 8 grams of dragon's blood, 12 grams of spina date seed, lepidium seed 10 Gram, 12 grams of motherwort, 12 grams of galangal, 6 grams of the tuber of pinellia, 8 grams of Ramulus Taxilli, 12 grams of radix paeoniae rubra, 15 grams of Cortex Eucommiae, 10 grams of hawthorn, excrementum pteropi 8 Gram, 6 grams of frankincense, 6 grams of myrrh, 12 grams of Radix Glycyrrhizae, 15 grams of cortex albiziae, 10 grams of Cortex Magnoliae Officinalis, 8 grams of citron.
3. the preparation method of drug according to claim 1 or claim 2, it includes the following steps：
（One）Stock
（1）Cape jasmine：Grey bits are weeded out, impurity is picked, pulverize sieving or cut off both ends；
（2）Snakegourd Fruit：Crude drug is taken, impurity and carpopodium are removed, is cleaned, is flattened, chopping or fritter are dry；
（3）Radix polygonati officinalis：Impurity is removed, soil, bored profit to uniform humidity inside and outside are cleaned, slice dries；
（4）Radix Salviae Miltiorrhizae：Net impurity is picked, rhizome is removed, is cleaned, is pulled out, be sliced, dry after moisturizing；
（5）Radix Ophiopogonis：Net impurity is picked, is soaked in water, is pulled out, the heart is pumped after moisturizing, then clean and dry；
（6）The membrane of a chicken's gizzard：Impurity is picked, rinses and dries；
（7）Corydalis tuber：Impurity is picked, is soaked in water, is cleaned, solarization is dried in the air, and is moistened to uniform humidity inside and outside, is sliced or broken；
（8）Rhizoma Chuanxiong：Impurity is picked, large and small is separated, is soaked in water, solarization is dried in the air, and is sliced after bored profit, dry；
（9）Purslane：Net impurity is picked, undesirable root is removed, is slightly moistened with water, segment is dried；
（10）Radix Curcumae：It is soaked in water, cleans, pull solarization out and dry in the air, moisturize, be sliced, dry；
（11）Peach kernel：Hard shell impurity is removed, sets in boiling water pot and boils to crust microcreping, pull out, is immersed in cold water, kind of a skin is removed in stranding, shines It is dry, it winnows with a dustpan net；
（12）Fructus Aurantii：Flesh, core are removed, edulcoration is slightly soaked, pulled out, softens, and it is degree that can pinch doubling with hand, and slice dries；
（13）Cassia twig：It is slightly impregnated, is pulled out with water, to saturating, slice dries, weeds out bits bored profit；
（14）Dragon's blood：Wipe dust away, knock fritter, in winter dryness weather, being placed in lime altar makes dry, then multiplies crisp grind；
（15）Spina date seed：Active compound is put into bamboo basket, sinks in clear water cylinder, benevolence is made to keep afloat, and thorn benevolence is pulled at the heavy bottom of shell out, It dries；
（16）Lepidium seed：Crude drug is taken, impurity is removed；
（17）Motherwort：Impurity is picked, cleans, moisturizes, segment is dried；
（18）Galangal：Net impurity is picked, is washed, is slightly soaked, pull out, moisturize, is sliced, dries；
（19）The tuber of pinellia：Impurity is picked, grey bits are weeded out；
（20）Ramulus Taxilli：It is eluted with water, moisturizes, segment is dried；
（21）Radix paeoniae rubra：Crude drug is taken, impurity is removed, size stepping is cleaned, moisturized, shave, dry, weeds out clast；
（22）Cortex Eucommiae：Tertia is removed, cleans, moisturizes, dice or strand dry；
（23）Hawthorn：Net impurity is picked, core is weeded out；
（24）Excrementum pteropi：Net impurity is picked, grey bits are smashed or weed out；
（25）Frankincense：Pick sand impurity；
（26）Myrrh：Impurity is picked, fragment is broken into；
（27）Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, moisturize, be sliced, airing；
（28）Cortex albiziae：Clear water, which impregnates, to be cleaned, and pulls out, equal big strip, then stripping and slicing or chopping are first divided into after bored profit, dry；
（29）Cortex Magnoliae Officinalis：It is soaked in water and pulls out, tertia is scraped off after moisturizing, clean, chopping is dried；
（30）Citron：Crude drug is taken, removes impurity, wash quickly is net, slightly moistens, chopping, and low temperature drying weeds out clast；
（Two）It prepares
（1）By the cape jasmine of the weight, Snakegourd Fruit, radix polygonati officinalis, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, the membrane of a chicken's gizzard, corydalis tuber, Rhizoma Chuanxiong, purslane, Radix Curcumae, peach Benevolence, Fructus Aurantii, cassia twig, dragon's blood, spina date seed, lepidium seed, motherwort, galangal, the tuber of pinellia, Ramulus Taxilli, radix paeoniae rubra, Cortex Eucommiae, hawthorn, five spirits Fat, frankincense, myrrh, Radix Glycyrrhizae, cortex albiziae, Cortex Magnoliae Officinalis, citron are put into decocting container, add 8 times of amounts of water, after impregnating 100 minutes, intense fire Boiling is decocted, then with being cooked by slow fire 20 minutes, filters to obtain first time decoction liquor, first time decoction liquor is poured into container；
（2）The dregs of a decoction of filtering are added into 6 times of amounts of water, are boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
（3）It decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.
CN201810470997.5A 2018-05-17 2018-05-17 It is a kind of to treat anginal drug and preparation method thereof Withdrawn CN108452258A (en)

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Application publication date: 20180828