CN108451786A - Container fills dentifrice composition - Google Patents
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- CN108451786A CN108451786A CN201810472090.2A CN201810472090A CN108451786A CN 108451786 A CN108451786 A CN 108451786A CN 201810472090 A CN201810472090 A CN 201810472090A CN 108451786 A CN108451786 A CN 108451786A
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- dentifrice composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 155
- 239000000551 dentifrice Substances 0.000 title claims abstract description 133
- 239000004615 ingredient Substances 0.000 claims abstract description 138
- -1 fatty acid ester Chemical class 0.000 claims abstract description 81
- 239000004698 Polyethylene Substances 0.000 claims abstract description 27
- 229920000573 polyethylene Polymers 0.000 claims abstract description 26
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000010521 absorption reaction Methods 0.000 claims abstract description 15
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960003500 triclosan Drugs 0.000 claims abstract description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 13
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- CAVXVRQDZKMZDB-UHFFFAOYSA-M sodium;2-[dodecanoyl(methyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CCS([O-])(=O)=O CAVXVRQDZKMZDB-UHFFFAOYSA-M 0.000 description 1
- ZNYIJXQYUNSKDX-NTISSMGPSA-M sodium;hydron;(2s)-2-(tetradecanoylamino)pentanedioate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O ZNYIJXQYUNSKDX-NTISSMGPSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000011067 sorbitan monolaureate Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
It being effectively prevented absorption of the effective component to container the present invention relates to a kind of, and has both the container dress dentifrice composition of good foaming characteristic and viscosity stability.The container dress dentifrice composition contains ingredient below (A)~(E)：(A) the one kind or two or more oil-soluble effective component in tocopherol, triclosan and isopropyl methyl phenol；(B) anion surfactant, content are 0.3 mass % or more and 2 mass % or less；(C) Crodaret, content are 0.15 mass % or more and 5 mass % or less；(D) polyoxyethylene sorbitan fatty acid ester；(E) water, its content is 15 mass % or more and 50 mass % or less, and ingredient (C) and the mass ratio ((C)/(D)) of the content of ingredient (D) are 0.2 or more and 5 hereinafter, the dentifrice composition is contained in the container for the innermost layer for having polyethylene.
Description
This case isOn November 1st, 2013, application No. is201380057412.2(PCT/JP2013/ 079661), it is entitledContainer fills dentifrice compositionPatent application divisional application.
Technical field
The present invention relates to a kind of containers being contained in container to fill dentifrice composition.
Background technology
In general, dentifrice composition is contained in the container for the tubulose for being formed with ejiction opening, it is above-mentioned by squeezing when in use
The main body of container can take out the dentifrice composition of content from ejiction opening.Also, in order to play desirable effect,
Contain various effective components in dentifrice composition.The effective component, which according to circumstances has, is attached to container in the combination sprayed
The worry that concentration in object reduces, therefore various researchs have been carried out in order to prevent the situation.
For example, being disclosed in patent document 1 containing vitamin E or derivatives thereof, anion surfactant and grinding
The Dentrifice composition of agent, by containing specific polyoxyethylene alkyl ether and polyethylene glycol hydrogenated castor-oil plant with specific amount ratio
Oil, to seek the absorption for inhibiting vitamin E etc. to container.In addition, disclose in patent document 2 containing triclosan and/or
The Dentrifice composition of isopropyl methyl phenol, by containing cationic surfactant and specific polyoxy with specific amount ratio
Ethylene hydrogenation castor oil, to seek the absorption for inhibiting triclosan etc. to container.
On the other hand, it discloses in patent document 3 when promoting the absorption of vitamine E nicotinate in oral cavity, makes alkyl
Any one of sodium sulphate and polyoxyethylene sorbitan fatty acid ester or Crodaret etc. non-ionic surface
The technology that activating agent coexists.
Existing technical literature
Patent document
Patent document 1：Japanese Unexamined Patent Publication 2005-247786 bulletins
Patent document 2：Japanese Unexamined Patent Publication 2005-179266 bulletins
Patent document 3：Japanese Unexamined Patent Application 58-96012 bulletins
Invention content
The present invention relates to a kind of containers to fill dentifrice composition, contains ingredient below (A)~(E)：
(A) the one kind or two or more oil-soluble effective component in tocopherol, triclosan and isopropyl methyl phenol；
(B) anion surfactant, content are 0.3 mass % or more and 2 mass % or less；
(C) Crodaret, content are 0.15 mass % or more and 5 mass % or less；
(D) polyoxyethylene sorbitan fatty acid ester；With
(E) water, content be 15 mass % or more and 50 mass % hereinafter,
Ingredient (C) and the mass ratio ((C)/(D)) of the content of ingredient (D) are 0.2 or more and 5 hereinafter, the dentifrice composition
Object is contained in the container for having polyethylene innermost layer.
Specific implementation mode
As described in patent document 1,2, using Crodaret, there is foaming characteristic to become inadequate
Worry.In addition, as described in patent document 3, even if individually and with sodium alkyl sulfate and polyoxyethylene sorbitol acid anhydride aliphatic acid
The nonionic surfactants such as ester or Crodaret can not also obtain and have both the suction for inhibiting effective component to container
The attached composition with both good foaming characteristics.
Therefore, it being effectively prevented absorption of the effective component to container the present invention relates to a kind of, and has both good blistering
Property container fill dentifrice composition.
Therefore, if present inventor is conceived in the container for being contained in dentifrice composition and having polyethylene innermost layer,
The case where absorption that then will produce specific oil-soluble effective component, the content of the ingredient in composition after preservation is reduced,
It is found that through anion surfactant and Crodaret containing specific quantity, and contains and polyoxyethylene
Rilanit special becomes the polyoxyethylene sorbitan fatty acid ester of specific mass ratio, it is hereby achieved that being effectively prevented
Absorption to said vesse, and have both the dentifrice composition of good foaming characteristic.
Container according to the present invention fills dentifrice composition, can be effectively prevented oil-soluble effective component to having polyethylene
The absorption of the container of innermost layer processed prevents the content of the oil-soluble effective component in the composition after preserving from reducing, and can be with
Play excellent foaming characteristic.
Hereinafter, the present invention is described in detail.
The container dress dentifrice composition of the present invention is contained in the container for having polyethylene innermost layer, and is contained and be selected from
One kind or two or more oil-soluble effective component (A) in tocopherol, triclosan and isopropyl methyl phenol.If will contain upper
The dentifrice composition for stating the oil-soluble effective component of ingredient (A) is contained in the container that innermost layer is polyethylene, and there will be guarantors
The worry of the content reduction of ingredient (A) after depositing.In the thickness for being present in composition or polyethylene layer close to the position of innermost layer
In the case that degree is thicker, have the tendency that the content reduction of ingredient (A), since the compatibility of ingredient (A) and polyethylene is high, thus holds
It easily is adsorbed in the innermost layer of container, it is believed that the concentration of the ingredient (A) in composition can be caused to reduce.The container dress of the present invention
Dentifrice composition can be effectively prevented the reduction of the concentration of ingredient (A).
As the tocopherol of ingredient (A), can enumerate：Acetic acid dl- alpha-tocopherol esters, dlo-tocopherol nicatinate.
The triclosan of ingredient (A) is the fungicide of the halogenated diphenyl ether type for the antimicrobial spectrum for having range wider, chemical name
For 2', 4,4'- tri- chloro- 2- hydroxy diphenyls ethers, such as by Ciba Specialty Chemicals Inc. with Irgacare
The trade name of MP is sold.The isopropyl methyl phenol of ingredient (A) is 1- hydroxyl -4- isopropyl -3- methylphenols, such as with commodity
Name BIOSOL is sold by Osaka Kasei Co., Ltd..
Isopropyl methyl phenol is also referred to as 3 methyl 4 isopropyl phenol, cymene -5- alcohol.
From the viewpoint of fully obtaining using the effect of mentioned component, the content of ingredient (A) is the present invention's
It is preferably 0.01 mass % or more, more preferably 0.02 mass % or more that container, which fills in dentifrice composition,.From ensuring composition
The viewpoint of good stability and the use feelings such as the taste of composition or stimulation from the perspective of, the content of ingredient (A) is at this
The container of invention fills preferably 2 mass % in dentifrice composition hereinafter, more preferably 1.5 mass % are hereinafter, further preferably
For 1 mass % or less.In addition, the content of ingredient (A) preferably 0.01~2 matter in the container dress dentifrice composition of the present invention
Measure %, more preferably 0.02~1.5 mass %, further preferably 0.02~1 mass %.
The container dress dentifrice composition of the present invention contains 0.3 mass % of anion surfactant (B) or more and 2 mass %
Below.By containing mentioned component (B), it can be ensured that good foaming characteristic or alveolar substance, excellent spatter property.As ingredient (B)
Anion surfactant, such as can enumerate：The acyl aminos such as acyl glutamic acid sodium, sarcosinate hydrochlorate, alkyl
The aliphatic ester of the alkylphosphonics such as sodium phosphate, alkyl sulfate salt, higher fatty acids sulfonated monoglycerides salt, isethionic acid
Salt, N- methyl long acyl taurines sodium salt, polyoxyethylene monoalkyl phosphate etc..These anion surfactants it is hydrophobic
The alkyl of base and the carbon atom number of acyl group are preferably 6~18, and more preferred carbon atom number is 10~14.Additionally, it is preferred that being sodium salt.
These can be used alone, and can also combine two or more to use.Wherein, go out from the viewpoint of foaming characteristic and low irritant etc.
Hair, more preferably a kind in acyl amino hydrochlorate, N- methyl long acyl taurine sodium salt and alkyl sulfate salt or
Two or more, from the viewpoints such as accessibility, further preferably alkyl sulfate salt.
From the viewpoint of ensuring good foaming characteristic, the content of ingredient (B) fills dentifrice composition in the container of the present invention
In be 0.3 mass % or more, preferably 0.5 mass % or more.From the viewpoint of deaeration when manufacture and the foaming characteristic of appropriateness
Viewpoint is set out, and the content of ingredient (B) is 2 mass % in the container dress dentifrice composition of the present invention hereinafter, preferably 1.8 matter
% is measured hereinafter, more preferably 1.5 mass % or less.In addition, the content of ingredient (B) fills dentifrice composition in the container of the present invention
In be 0.3~2 mass %, preferably 0.5~1.8 mass %, more preferably 0.5~1.5 mass %.
The container dress dentifrice composition of the present invention contains 0.15 mass % of Crodaret (C) or more and 5 matter
Measure % or less.By containing the Crodaret of ingredient (C) with the amount, ingredient (A) can be effectively prevented to holding
The absorption of device, and by being used in combination with aftermentioned ingredient (D), good foaming characteristic can be kept and inhibit the viscosity under low temperature
Rise.From prevent ingredient (A) to container absorption and ensure good foaming characteristic viewpoint and assign low temperature under viscosity it is steady
From the perspective of qualitative, the average addition molal quantity of the ethylene oxide (EO) in ingredient (C) is preferably 15~80, more preferably
20~60, further preferably 25~50.
From the viewpoint of being effectively prevented ingredient (A) to the absorption of container, the content of ingredient (C) is in container of the invention
Fill in dentifrice composition is 0.15 mass % or more, preferably 0.2 mass % or more, more preferably 0.3 mass % or more.From
From the perspective of keeping the viscosity under good foaming characteristic, inhibition low temperature to rise by being used in combination with ingredient (D), ingredient (C)
Content is 5 mass % in the container dress dentifrice composition of the present invention hereinafter, preferably 3 mass % or less.In addition, ingredient (C)
Content the present invention container dress dentifrice composition in be 0.15~5 mass %, preferably 0.2~3 mass %, more preferably
For 0.3~3 mass %.
The container dress dentifrice composition of the present invention contains polyoxyethylene sorbitan fatty acid ester (D).By with ingredient
(C) along with mentioned component (D), absorption of the ingredient (A) to container can be effectively prevented, prevent in dentifrice composition at
Divide the reduction of the content of (A), and bring excellent foaming characteristic, furthermore it is possible to the viscosity stability under improving low temperature.Ingredient
(D) be preferably carbon atom number be 8~22 aliphatic acid ester, more preferably carbon atom number be 12~20 aliphatic acid ester,
The ester for the aliphatic acid that further preferably carbon atom number is 16~20.In addition, the average addition of the ethylene oxide in ingredient (D) rubs
Your number is preferably 2~40, more preferably 5~30, further preferably 15~25.Further, the HLB of ingredient (D) is preferably 8
~20, more preferably 10~18.
In addition, HLB (the balance ＜ Hydrophilic-Lypophilic Balance ＞ of hydrophilic-lipophilic) indicates table
The molecular weight of shared hydrophilic group part in the total molecular weight of face activating agent, the HLB of ingredient (D) is according to Griffin
(Griffin) formula and find out.
As ingredient (D), more specifically, such as can enumerate：Polyoxyethylene sorbitan monolaurate, polyoxy
Ethylene sorbitan list myristinate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitol acid anhydride list
Stearate, polyoxyethylene sorbitan monooleate etc..These can be used alone, and can also combine two or more
It uses.Wherein, from the viewpoint of playing excellent foaming characteristic and improving low-temperature stability, it is preferably selected from polyoxyethylene
In sugar alcohol acid anhydride monopalmitate, polyoxyethylene sorbitan monostearate and polyoxyethylene sorbitan monooleate
It is one kind or two or more, more preferably polyoxyethylene sorbitan monostearate.
From absorption of the ingredient (A) to container is effectively prevented, inhibit the content of the ingredient (A) in the composition after preserving
From the perspective of reducing and having both excellent foaming characteristic and good low-temperature stability, ingredient (C) and the content of ingredient (D)
Mass ratio ((C)/(D)) is 0.2 or more, preferably 0.5 or more, more preferably 0.7 or more.Composition after inhibiting preservation
In ingredient (A) content reduction and from the perspective of ensuring foaming characteristic, the quality of ingredient (C) and the content of ingredient (D)
Than ((C)/(D)) it is 5 hereinafter, preferably 4 hereinafter, further from the viewpoint of the rising for inhibiting the viscosity under low temperature environment,
Preferably 2 hereinafter, more preferably 1.7 hereinafter, further preferably 1.5 or less.In addition, the content of ingredient (C) and ingredient (D)
Mass ratio ((C)/(D)) be 0.2~5, preferably 0.5~4, more preferably 0.5~2, further preferably 0.5~1.7,
Still more preferably it is 0.7~1.5.
In addition, from the viewpoint of playing excellent foaming characteristic and the viscosity under low temperature is inhibited to rise, ingredient (D's) contains
Measure the present invention container dress dentifrice composition in preferably 0.1 mass % or more, more preferably 0.15 mass % or more, into
One step is preferably 0.3 mass % or more.From with ingredient (C) and use in the case of also fully blistering, and inhibit low temperature under viscosity
From the perspective of rising, the content of ingredient (D) in the container dress dentifrice composition of the present invention preferably 5 mass % hereinafter, more
Add preferably 3 mass % or less.In addition, the content of ingredient (D) is preferably 0.1~5 mass %, more preferably 0.15~3 matter
Measure %, further preferably 0.3~3 mass %.
The container dress dentifrice composition of the present invention contains 15 mass % of water (E) or more and 50 mass % or less.In the present invention
Ingredient (E) water, be not only to be matched with the Purified Water etc. in dentifrice composition, also include being used when for example preparing such as 70%
Moisture contained in each ingredient that D-sorbitol solution coordinates like that refers to whole moisture contained in dentifrice composition.It is each from making
The viewpoint and make from from the perspective of the ejection of container is good that ingredient disperses or dissolves well, the content of mentioned component (E)
It is 15 mass % or more, preferably 18 mass % or more in the container dress dentifrice composition of the present invention, even if being above-mentioned moisture
The storage stability of ingredient (A) is also ensured in content.From being maintained at intraoral good dispersibility and good shape-retaining ability
From the perspective of, the content of ingredient (E) is 50 mass % in the container dress dentifrice composition of the present invention hereinafter, preferably 40 matter
Measure % or less.In addition, the content of ingredient (E) is 15~50 mass % in the container dress dentifrice composition of the present invention, preferably
18~40 mass %.
In addition, amount of moisture in the container dress dentifrice composition of the present invention can also by according to amount of moisture joined together and
Amount of moisture in ingredient joined together is calculated and is calculated, such as can be measured using karl Fischer moisture meter.As
Determination of trace water device (flat natural pond industry) can be used for example in karl Fischer moisture meter.The group that cleans the teeth can be taken in the apparatus
Object 5g is closed, is allowed to suspend by absolute methanol 25g, divides and suspension 0.02g is taken to measure amount of moisture.
The container dress dentifrice composition of the present invention preferably further contains binder (F).By containing mentioned component (F),
The viscosity of appropriateness is assigned to have good shape-retaining ability to composition, even if for tubular container (tube container) or squeezing
The container that pressure vessel etc. is sprayed by extruding, is also ensured ejection.As ingredient (F), such as can enumerate：Alginic acid
Sodium, sodium carboxymethylcellulose, carragheen, xanthans, Sodium Polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, Huang
Alpine yarrow glue, Arabic gum, guar gum, Karaya Gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, cartilage
Plain sodium sulphate and methoxy-ethylene copolymer-maleic anhydride.These can be used alone, and can also combine and contain two or more.
Wherein, be preferably selected from it is one kind or two or more in sodium carboxymethylcellulose, carragheen and xanthans, further preferably combination contain
There is two or more.
From the viewpoint of ensuring storage stability, shape-retaining ability and ejection, the content of ingredient (F) is in container of the invention
Fill in dentifrice composition is preferably 0.3 mass % or more, more preferably 0.5 mass % or more.Divide well from each ingredient is made
Dissipate or dissolving from the perspective of, the content of ingredient (F) in the container dress dentifrice composition of the present invention preferably 2 mass % with
Under, more preferably 1.5 mass % are hereinafter, further preferably 1.2 mass % or less.In addition, the content of ingredient (F) is in this hair
Preferably 0.3~2 mass %, more preferably 0.5~1.5 mass % in bright container dress dentifrice composition, further preferably
For 0.5~1.2 mass %.
The container dress dentifrice composition of the present invention, which preferably further contains, is selected from propylene glycol, polyethylene glycol and 1,3 butylene glycol
In one kind or two or more polyalcohol.By containing above-mentioned polyalcohol, can effectively further inhibit under low temperature environment
The rising of viscosity.Wherein, from the viewpoint of the rising for more effectively inhibiting viscosity, preferably propylene glycol.Under imparting low temperature
Good viscosity stability from the perspective of, the content of above-mentioned polyalcohol in the container dress dentifrice composition of the present invention preferably
For 1 mass % or more, more preferably 2 mass % or more.From the viewpoint of taste and use feeling, the content of polyalcohol is at this
Preferably 10 mass % are hereinafter, more preferably 8 mass % or less in the container dress dentifrice composition of invention.In addition, above-mentioned more
The content of first alcohol is preferably 1~10 mass %, more preferably 2~8 mass % in the container dress dentifrice composition of the present invention.
The container dress dentifrice composition of the present invention preferably further contains sugar alcohol.By containing above-mentioned sugar alcohol, can improve
The stability of ingredient (A), and good use feeling or refrigerant sense, taste etc. can also be assigned.As above-mentioned sugar alcohol, Ke Yilie
It lifts：Antierythrite, D-sorbite, xylitol, lactitol, isomalt, maltitol, mannitol etc..These can be with
It is used alone a kind, two or more can also be combined to use.Wherein, antierythrite, xylitol and D-sorbite are preferably selected from
In it is one kind or two or more.
From the viewpoint of further increasing the viewpoint of stability of ingredient (A) and taste, the content of sugar alcohol is in the present invention
Container dress dentifrice composition in preferably 30 mass % or more, more preferably 40 mass % or more, further preferably 50
Quality % or more.From the viewpoint of solubility with the balance or shape-retaining ability of viscosity and intraoral dispersibility, sugar alcohol
Content is preferably 75 mass % in the container dress dentifrice composition of the present invention hereinafter, more preferably 70 mass % or less.Separately
Outside, from the viewpoint of construction viscosity of viewpoint and imparting appropriateness of use feeling or refrigerant sense etc., erythrose is selected from sugar alcohol
The mass ratio (the low sugar alcohol/sugar alcohol of solubility) of the content of the low sugar alcohol of solubility in alcohol, isomalt, mannitol
Preferably 0.3~1, more preferably 0.5~0.8.
In the container dress dentifrice composition of the present invention, from the viewpoint of the stability for further increasing ingredient (A), sugar alcohol
Preferably 40 mass % or more in dentifrice composition are filled with the container for being aggregated in the present invention of the content of polyalcohol, more preferably
50 mass % or more, further preferably 60 mass % or more, and for 80 mass % hereinafter, more preferably 75 mass % with
Under, further preferably 70 mass % or less.In addition, the container dress for being aggregated in the present invention of the content of sugar alcohol and polyalcohol cleans the teeth
It is preferably 40~80 mass %, more preferably 50~75 mass %, further preferably 60~70 mass % in composition.
It, can be in the effect for not damaging the present invention other than mentioned component in the container dress dentifrice composition of the present invention
Suitably contain the other ingredients that can be used in oral cavity composition, such as the supply of grinding agent, blowing promotor, fluorine ion in the range of fruit
Compound, fragrance, pH adjusting agent, preservative etc..
Group that can dentifrice composition suitably be made according to purposes in the container dress dentifrice composition of the present invention, gel cleans the teeth
Close object.
The present invention container dress dentifrice composition can be manufactured according to common method, can be by properly mixing on
It states ingredient and obtains.In addition, for example, it is also possible to be pre-mixed ingredient (A), ingredient (C), ingredient (D) or fragrance etc. oil-soluble
These are mixed and are obtained in addition, properly mixing the water soluble ingredients such as ingredient (B) or water with after remaining ingredient by ingredient.
Container used in the container dress dentifrice composition of the present invention has the innermost layer of polyethylene.From what is accommodated
From the perspective of the ejection of dentifrice composition, said vesse preferably forms tubular container made of ejiction opening via shoulder.
Specifically, said vesse is made of container body and head cover, container body has ejiction opening and trunk.Trunk is by cylinder
One end welding of shape forms, and the peripheral end portion of the other end of trunk and shoulder connects, and above-mentioned shoulder makes ejiction opening in
Centre is prominent and has.In general, the trunk of container body has multilayered structure, end welding is filled with to dentifrice composition.
From the perspective of the welding easiness of the end of the trunk of container body, container has the innermost layer of polyethylene, preferably
Have the innermost layer of low density polyethylene (LDPE), more preferably has the innermost layer of straight-chain low density polyethylene (LDPE).As other
Layer, can enumerate：The synthetic resin layers such as the metal layer such as aluminium, polypropylene or polyethylene terephthalate, layer made of paper
Deng.The thickness of the polyethylene innermost layer of the container of the present invention is preferably 50 μm or more and 200 μm hereinafter, preferably 70 μm or more
And 180 μm or less.
Ejiction opening is protruded with tubular, and the fastener or thread groove for installing head cover are formed in the peripheral surface of tubular.
Have on the inside of head cover and is formed with the protrusion engaged for the fastener with ejiction opening or for the thread groove with ejiction opening
The canister portion of the thread groove of twist-on is carried out, ejiction opening can seal opening for ejiction opening front end by locking with head cover or twist-on
Mouthful.About the shoulder that the other end with trunk is connect, from the viewpoint for carrying out locking or twist-on by ejiction opening and head cover and really
Protect trunk it is three-dimensional from the perspective of, the thickness of shoulder is preferably 3 times of trunk thickness or more of thickness, further it is excellent
It is selected as 4 times or more of thickness, from the viewpoint of the mouldability of shoulder, preferably 0.8mm or more, preferably 1mm or more, into one
Step is preferably 1.2mm or more, and from the viewpoint of usability or cost, preferably 2.5mm is hereinafter, preferably 2mm or less.This hair
Bright dentifrice composition is the thicker polyethylene system or low density polyethylene (LDPE) system of shoulder as described above, even holding near shoulder
The container of easy adsorption component (A) can also inhibit the reduction of the content of the ingredient (A) after preserving.
Although the oil-soluble medicine for the polyethylene innermost layer or shoulder adsorption component (A) having in container as described above
Effect ingredient, the content for easily reducing ingredient (A) in composition, but the container dress dentifrice composition of the present invention can be effectively
The situation is prevented, and there is excellent foaming characteristic, even and if composition can also be stably kept at low ambient temperatures
Viscosity.
About above-mentioned implementation form, the present invention further discloses preferred composition below.
[1] a kind of container fills dentifrice composition, wherein contains ingredient below (A)~(E)：
(A) the one kind or two or more oil-soluble effective component in tocopherol, triclosan and isopropyl methyl phenol；
(B) anion surfactant, content are 0.3 mass % or more and 2 mass % or less；
(C) Crodaret, content are 0.15 mass % or more and 5 mass % or less；
(D) polyoxyethylene sorbitan fatty acid ester；
(E) water, content be 15 mass % or more and 50 mass % hereinafter,
Ingredient (C) and the mass ratio ((C)/(D)) of the content of ingredient (D) are 0.2 or more and 5 hereinafter, above-mentioned dentifrice composition
Object is contained in the container for having polyethylene innermost layer.
[2] as the container of above-mentioned [1] fills dentifrice composition, wherein the content of ingredient (A) be preferably 0.01 mass % with
On, more preferably 0.02 mass % or more, and preferably 2 mass % are hereinafter, more preferably 1.5 mass % are hereinafter, into one
Step is preferably 1 mass % or less.
[3] as the container of above-mentioned [1] or [2] fills dentifrice composition, wherein ingredient (B) is preferably selected from acyl glutamic acid
The alkylphosphonics such as the acyl aminos such as sodium, sarcosinate hydrochlorate, alkyl phosphoric acid sodium, alkyl sulfate salt, higher fatty acids
Sulfonated monoglycerides salt, the fatty acid ester salt of isethionic acid, N- methyl long acyl taurine sodium salt and polyoxyethylene monoalkyl
One kind or two or more in phosphate, the alkyl of more preferred hydrophobic group and the carbon atom number of acyl group are 6~18, further preferably
It is one kind or two or more in acyl amino hydrochlorate, N- methyl long acyl taurine sodium salt and alkyl sulfate salt.
[4] as the container of above-mentioned [1] to any one of [3] fills dentifrice composition, wherein the content of ingredient (B) is preferably
0.5 mass % or more, and preferably 1.8 mass % are hereinafter, more preferably 1.5 mass % or less.
[5] as the container of above-mentioned [1] to any one of [4] fills dentifrice composition, wherein the ethyleneoxy in ingredient (C)
Average addition molal quantity be preferably 15~80, more preferably 20~60, further preferably 25~50.
[6] as the container of above-mentioned [1] to any one of [5] fills dentifrice composition, wherein the content of ingredient (C) is preferably
0.2 mass % or more, more preferably 0.3 mass % or more, and preferably 3 mass % or less.
[7] as the container of above-mentioned [1] to any one of [6] fills dentifrice composition, wherein ingredient (D) is preferably carbon atom
The ester for the aliphatic acid that the ester for the aliphatic acid that number is 8~22, more preferably carbon atom number are 12~20, further preferably carbon are former
The ester for the aliphatic acid that subnumber is 16~20.
[8] as the container of above-mentioned [1] to any one of [7] fills dentifrice composition, wherein the ethyleneoxy in ingredient (D)
Average addition molal quantity be preferably 2~40, more preferably 5~30, further preferably 15~25.
[9] as the container of above-mentioned [1] to any one of [8] fills dentifrice composition, wherein the HLB of ingredient (D) is preferably 8
~20, more preferably 10~18.
[10] as the container of above-mentioned [1] to any one of [9] fills dentifrice composition, wherein ingredient (D) is preferably selected from poly-
Ethylene oxide Span-20, polyoxyethylene sorbitol acid anhydride list myristinate, polyoxyethylene sorbitol acid anhydride
1 kind or 2 in monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate
Kind or more, more preferably it is selected from polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitol acid anhydride monostearate
It is one kind or two or more in ester and polyoxyethylene sorbitan monooleate, further preferably polyoxyethylene sorbitol acid anhydride
Monostearate.
[11] as the container of above-mentioned [1] to any one of [10] fills dentifrice composition, wherein ingredient (C) and ingredient (D)
The mass ratio ((C)/(D)) of content is preferably 0.5 or more, more preferably 0.7 or more, and preferably 4 hereinafter, be more preferably
2 hereinafter, further preferably 1.7 hereinafter, still more preferably be 1.5 or less.
[12] as the container of above-mentioned [1] to any one of [11] fills dentifrice composition, wherein the content of ingredient (D) is preferred
For 0.1 mass % or more, more preferably 0.15 mass % or more, further preferably 0.3 mass % or more, and preferably 5
Quality % is hereinafter, more preferably 3 mass % or less.
[13] as the container of above-mentioned [1] to any one of [12] fills dentifrice composition, wherein the content of ingredient (E) is preferred
For 18 mass % or more, and preferably 40 mass % or less.
[14] as the container of above-mentioned [1] to any one of [13] fills dentifrice composition, wherein above-mentioned dentifrice composition is into one
Step contains (F) binder, and ingredient (F) is preferably selected from sodium alginate, sodium carboxymethylcellulose, carragheen, xanthans, polypropylene
Sour sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, bassora gum, Arabic gum, guar gum, Karaya Gum, locust bean gum,
1 in gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate and methoxy-ethylene copolymer-maleic anhydride
Kind or two or more, it is more preferably one kind or two or more in sodium carboxymethylcellulose, carragheen and xanthans.
[15] as the container of above-mentioned [14] fills dentifrice composition, wherein the content of ingredient (F) be preferably 0.3 mass % with
On, more preferably 0.5 mass % or more, and preferably 2 mass % hereinafter, more preferably 1.5 mass % hereinafter, further
Preferably 1.2 mass % or less.
[16] as the container of above-mentioned [1] to any one of [15] fills dentifrice composition, wherein above-mentioned dentifrice composition is into one
Step preferably comprises propylene glycol containing the one kind or two or more polyalcohol in propylene glycol, polyethylene glycol and 1,3-BDO.
[17] as the container of above-mentioned [16] fills dentifrice composition, wherein the content of above-mentioned polyalcohol be preferably 1 mass % with
On, more preferably 2 mass % or more, and preferably 10 mass % are hereinafter, more preferably 8 mass % or less.
[18] as the container of above-mentioned [1] to any one of [17] fills dentifrice composition, wherein above-mentioned dentifrice composition is into one
Step contains sugar alcohol, and sugar alcohol is preferably selected from antierythrite, D-sorbite, xylitol, lactitol, isomalt, maltose
It is one kind or two or more in alcohol, mannitol, a kind or 2 more preferably in antierythrite, xylitol and D-sorbite
Kind or more.
[19] as the container of above-mentioned [18] fills dentifrice composition, wherein the content of sugar alcohol is preferably 30 mass % or more, more
Add preferably 40 mass % or more, further preferably 50 mass % or more, and preferably 75 mass % are hereinafter, be more preferably
70 mass % or less.
[20] as the container of above-mentioned [18] or [19] fills dentifrice composition, wherein be selected from antierythrite, reduction in sugar alcohol
The mass ratio (the low sugar alcohol/sugar alcohol of solubility) of the content of sugar alcohol in palatinose, mannitol is preferably 0.3~0.9, more
Add preferably 0.5~0.8.
[21] as the container of above-mentioned [1] to any one of [20] fills dentifrice composition, wherein container has polyethylene
Innermost layer is preferably provided with the innermost layer of low density polyethylene (LDPE), more preferably has the most interior of straight-chain low density polyethylene (LDPE)
Layer.
[22] as the container of above-mentioned [1] to any one of [21] fills dentifrice composition, wherein container is to be formed via shoulder
Tubular container made of ejiction opening, shoulder and ejiction opening are preferably polyethylene system, more preferably low density polyethylene (LDPE) system, shoulder
Thickness be preferably 0.8mm or more, more preferably 1mm or more, further preferably 1.2mm or more, and preferably 2.5mm with
Under, more preferably 2mm or less.
[23] a kind of dentifrice composition of above-mentioned [1] to any one of [21] has polyethylene innermost layer for being contained in
Container in purposes.
[24] such as the purposes of above-mentioned [23], wherein said vesse be 0.8mm or more via thickness and 2.5mm is below
Polyethylene shoulder forms tubular container made of ejiction opening.
[25] a kind of oil-soluble effective component of inhibition ingredient (A) is to have poly- second to the method for the absorption of container
Alkene innermost layer and be 0.8mm or more via thickness and 2.5mm polyethylene shoulders below form tubulose made of ejiction opening
The dentifrice composition of above-mentioned [1] to any one of [21] is accommodated in container.
Embodiment
Hereinafter, based on embodiment come specifically the present invention will be described.As long as in addition, without special instruction in table, respectively at
The content divided indicates quality %.
[embodiment 1~12, comparative example 1~4]
Be formulated, dissolved at 60 DEG C so that ingredient (C) and ingredient (D) are dissolved according to shown in table 1~3, addition at
(A) is divided to be mixed with fragrance, to obtain oil-soluble mixture.On the other hand, ingredient (A), ingredient (C), ingredient (D) will be removed
And the ingredient other than fragrance mixes to obtain water soluble mixt.Further, above-mentioned oil-soluble mixture is mixed with water solubility
Object mixing is closed, each dentifrice composition is prepared.In addition, using tubular container as container.The trunk of the container body of tubular container
Portion is made of multilayer resin layer, and the multilayer resin layer is by 50 μm/adhesive/high-density polyethylene of printing layer/low density polyethylene (LDPE)
80 μm of alkene/12 μm of adhesive/aluminium/12 μm of adhesive/polyethylene terephthalate/adhesive/straight-chain low density polyethylene
100 μm of compositions of alkene, wherein innermost layer is straight-chain low density polyethylene (LDPE), and outermost layer has printing layer (comprising paint), middle layer tool
Standby aluminium layer.Tubular container has the shoulder for being provided integrally with ejiction opening, and shoulder and ejiction opening are low density polyethylene (LDPE) systems, shoulder
Thickness average out to 1.3mm.In addition, ejiction opening has thread groove, the dentifrice composition obtained is filled in said vesse, is twisted
It connects head cover and is sealed and preserve again, for the dentifrice composition sprayed from ejiction opening after preservation, according to method shown in following
Carry out the evaluation of the content and viscosity of each ingredient.Foaming characteristic is evaluated to the dentifrice composition before preservation.
It shows the result in table 1~3.
《The residual rate of acetic acid dl- alpha-tocopherol esters, triclosan and isopropyl methyl phenol》
Prepared each dentifrice composition is filled into above-mentioned tubular container, after lid twist-on is sealed, respectively
It is preserved 3 weeks in 5 DEG C, 50 DEG C of thermostat.After preservation, by the dentifrice composition preserved from the spray of tubular container at 50 DEG C
Outlet is continuously squeezed out 3 times with about 1g every time, is continuously increased spray volume, is become 3 kinds of dentifrice compositions of about 1g, about 2g, about 3g.Needle
To these each dentifrice compositions, acetic acid dl- alpha-tocopherol esters, triclosan and isopropyl methyl phenol are measured by HPLC respectively
Amount, above-mentioned 3 kinds of compositions are measured, the content of every 1g is converted into and calculates average value, as " 50 DEG C preserve after
Amount ".
In addition, for the dentifrice composition after preserving at 5 DEG C, removal is from after ejiction opening sprays about 20g, from ejiction opening
Spray about 1g, the dentifrice composition as measurement.Also, acetic acid dl- alpha-tocopherol esters, trichlorine are measured by HPLC respectively
Raw and isopropyl methyl phenol amount, using the content of every 1g dentifrice compositions as " amounts of 5 DEG C of preservation product ".
The residual rate of acetic acid dl- alpha-tocopherol esters, triclosan and isopropyl methyl phenol after preservation is with " 50 DEG C of preservations
Amount afterwards "/" amount after 5 DEG C of preservations " is defined, and is shown the result in table 1~2.In addition, the measurement of HPLC pass through it is below
Condition carries out.
The determination condition ＞ of ＜ HPLC (high performance liquid chromatography)
Device：Hitachi high performance liquid chromatography La chromElite
Column：
Triclosan, tocopherol：LiChromCART 125-4Superspherspher100RP-18(e)(Merck)
Isopropyl methyl phenol：L-column ODS5 μm (chemical substance assessing mechanisms)
Column temperature：40℃
Mobile phase：
Triclosan：Methanol (the methanol of 0.1w/v% phosphoric acids：Water=8:2)
Tocopherol：Methanol (the methanol of 0.1w/v% phosphoric acids：Water=98:2) flow：1.0mL/Min
Isopropyl methyl phenol：Methanol/water mixed liquor (methanol：Water=3:2)
Sample injection rate：20μL
Measure wavelength：
Triclosan：250nm
Tocopherol：280nm
Isopropyl methyl phenol：279nm
《Foaming characteristic》
Each 1g dentifrice compositions of 3 professional evaluator's Examples and comparative example are in toothbrush (Deep Clean, bristle
Hardness be common, compact brush head) on, brush teeth about 2 minutes, according to following 4 grades standard to foaming characteristic (foam
Amount) it is evaluated.The aggregate value by these 3 evaluations is indicated in table 1~2.
4：The amount of foam is very more
3：The amount of foam is more
2：The amount of foam is few
1：The amount of foam is few (not blistering)
《Low temperature and viscosity at room temperature》
The viscosity of dentifrice composition is set as determination condition below, using the value measured at 5 DEG C as viscous under low temperature
Degree, using the value measured at 25 DEG C as viscosity at room temperature, is evaluated according to following standards.In addition, about each temperature
The measurement of viscosity, 5 DEG C are measured after preserving 1 week at 5 DEG C, and 25 DEG C of viscosity is carried out after being preserved 24 hours at 25 DEG C
It measures.
Sensing equipment：Helipath type viscosimeters DVR-B2 (Toki Sangyo Co., Ltd.'s manufacture)
Measure rotor：25 DEG C of rotors T-C, 5 DEG C of rotor T-E
Revolution：2.5rpm
Minute：60 seconds
[table 1]
(* 1) EMANON CH-40 (Kao Corp's manufacture)
(* 2) RHEODOL TW-S120V (Kao Corp's manufacture)
1220 ＞ of (* 3) CMC DAICEL ＜ (DAICEL Co., Ltd. manufacture)
(* 4) SOAGEENA VX23 (MRC POLYSACCHARIDE Co., Ltd. manufacture)
(* 5) SORBOSIL AC77 (PT PQ Sillicas Indonesia manufactures)
(* 6) SYLOPURE 25 (Fuji Silysia Chemical, Ltd. manufacture)
[table 2]
(* 1) EMANON CH-40 (Kao Corp's manufacture)
(* 2) RHEODOL TW-S120V (Kao Corp's manufacture)
1220 ＞ of (* 3) CMC DAICEL ＜ (DAICEL Co., Ltd. manufacture)
(* 4) SOAGEENA VX23 (MRC POLYSACCHARIDE Co., Ltd. manufacture)
(* 5) SORBOSIL AC77 (PT PQ Sillicas Indonesia manufactures)
(* 6) SYLOPURE 25 (Fuji Silysia Chemical, Ltd. manufacture)
[table 3]
(* 1) EMANON CH-40 (Kao Corp's manufacture)
(* 2) RHEODOL TW-S120V (Kao Corp's manufacture)
1220 ＞ of (* 3) CMC DAICEL ＜ (DAICEL Co., Ltd. manufacture)
(* 4) SOAGEENA VX23 (MRC POLYSACCHARIDE Co., Ltd. manufacture)
(* 5) SORBOSIL AC77 (PT PQ Sillicas Indonesia manufactures)
(* 6) SYLOPURE 25 (Fuji Silysia Chemical, Ltd. manufacture)
(* 7) AMISOFT MS-11 (Ajincomoto Co., Inc's manufacture)
(* 8) NIKKOL LMT (Nikko Chemicals Co., Ltd. manufacture)
(* 9) EMANON CH-25 (Kao Corp's manufacture)
(* 10) EMANON CH-60K (Kao Corp's manufacture)
(* 11) RHEODOL TW-O106V (Kao Corp's manufacture)
According to the result of table 1~3 it is found that the foaming characteristic of the comparative example 1 without containing ingredient (C) and ingredient (D) is very good,
In contrast, the residual rate of ingredient (A) after being saved is relatively low, do not contain ingredient (D) although 2 ingredient of comparative example (A) preserve after
Residual rate it is higher, but intraoral frothing capacity is insufficient in brushing action, and the viscosity under low temperature rises.In addition,
The content of comparative example 3 and ingredient (E) containing ingredient (D) but without containing ingredient (C) is more than that the comparative example 4 of 50 mass % is equal
The residual rate of ingredient (A) after being saved is relatively low, can not obtain sufficient storage stability.On the other hand, the group of embodiment 1~12
Object is closed compared with the composition of comparative example 1~4, the residual rate of the oil-soluble effective component of ingredient (A) after being saved is higher, and
It may insure to blister.In addition, Examples 1 to 5,7~8,10~12 dentifrice composition further suppress in the viscosity under low temperature
Rise, Examples 1 to 4,7,11 dentifrice composition maintain the residual rate of ingredient (A) after being saved higher, and foaming characteristic is good
It is good, inhibit the effect that the viscosity under low temperature rises high.
Claims (25)
1. a kind of container fills dentifrice composition, wherein
Contain ingredient below (A)~(E)：
(A) the one kind or two or more oil-soluble effective component in tocopherol, triclosan and isopropyl methyl phenol, ingredient
(A) content is 0.01 mass % or more and 2 mass % or less, wherein in the case of containing triclosan as ingredient (A), three
The content of chlorine life is no more than《Cosmetics health specification》Specified in maximum usage amount；
(B) anion surfactant, content are 0.3 mass % or more and 2 mass % or less；
(C) Crodaret, content is 0.15 mass % or more and 5 mass % hereinafter, ethylene in ingredient (C)
The average addition molal quantity of oxygroup is 15~80；
(D) polyoxyethylene sorbitan fatty acid ester, ingredient (D) are the ester for the aliphatic acid that carbon atom number is 8~22, ethylene oxy
The addition molal quantity of base is 2~40；
(E) water, content are 15 mass % or more and 50 mass % or less；And
(F) binder, content are 0.3 mass % or more and 2 mass % or less；
As the mass ratio of ingredient (C) and the content of ingredient (D), (C)/(D) is 0.2 or more and 2 hereinafter, the dentifrice composition
It is contained in the container for the innermost layer for having polyethylene.
2. container as described in claim 1 fills dentifrice composition, wherein
It is 0.8mm or more and 2.5mm polyethylene systems below that the container of the above-mentioned innermost layer for having polyethylene, which is via thickness,
Shoulder is to form tubular container made of ejiction opening.
3. container as described in claim 1 fills dentifrice composition, wherein
The dentifrice composition further contains sugar alcohol.
4. container as claimed in claim 3 fills dentifrice composition, wherein
The content of the sugar alcohol is 30 mass % or more and 75 mass % or less.
5. container as described in claim 1 fills dentifrice composition, wherein
Ingredient (F) is selected from sodium alginate, sodium carboxymethylcellulose, carragheen, xanthans, Sodium Polyacrylate, hydroxy ethyl fiber
Element, hydroxypropyl cellulose, pectin, bassora gum, Arabic gum, guar gum, Karaya Gum, locust bean gum, gellan gum, tamarind
It is one kind or two or more in glue, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate and methoxy-ethylene copolymer-maleic anhydride.
6. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The dentifrice composition further contains one kind or two or more in propylene glycol, polyethylene glycol and 1,3 butylene glycol
Polyalcohol.
7. container as claimed in claim 6 fills dentifrice composition, wherein
The content of the polyalcohol is 1 mass % or more and 10 mass % or less.
8. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The content of ingredient (A) is 0.02 mass % or more and 1.5 mass % or less.
9. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The content of ingredient (A) is 0.02 mass % or more and 1 mass % or less.
10. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The carbon atom number of acyl glutamic acid sodium, acyl group that ingredient (B) is 6~18 for the carbon atom number selected from acyl group is 6~18
It is one kind or two or more in the alkyl sulfate that the carbon atom number of N- methyl long acyl taurine sodium salt and alkyl is 6~18.
11. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The content of ingredient (B) is 0.5 mass % or more and 1.8 mass % or less.
12. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The average addition molal quantity of ethyleneoxy in ingredient (C) is 20~60.
13. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The content of ingredient (C) is 0.2 mass % or more and 3 mass % or less.
14. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
Ingredient (D) is the ester for the aliphatic acid that carbon atom number is 12~20, and the addition molal quantity of ethyleneoxy is 5~30.
15. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
Ingredient (D) be selected from polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitol acid anhydride list myristinate,
Polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitol acid anhydride
It is one kind or two or more in monoleate.
16. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
As the mass ratio of ingredient (C) and the content of ingredient (D), (C)/(D) is 0.2 or more and 1.5 or less.
17. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The content of ingredient (D) is 0.1 mass % or more and 3 mass % or less.
18. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The content of ingredient (E) is 15 mass % or more and 40 mass % or less.
19. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The content of ingredient (F) is 0.5 mass % or more and 1.2 mass % or less.
20. the container as described in any one of claim 3~5 fills dentifrice composition, wherein
The sugar alcohol is selected from antierythrite, D-sorbite, xylitol, lactitol, isomalt, maltitol, sweet dew
It is one kind or two or more in sugar alcohol.
21. the container as described in any one of claim 3~5 fills dentifrice composition, wherein
As containing for the low sugar alcohol of the solubility in antierythrite, isomalt, mannitol in the sugar alcohol
The mass ratio of amount, the low sugar alcohol/sugar alcohol of solubility are 0.3~0.9.
22. as container according to any one of claims 1 to 5 fills dentifrice composition, wherein
The container has the innermost layer of low density polyethylene (LDPE).
23. dentifrice composition described in any one of claim 1~22 has polyethylene innermost layer for being contained in
Purposes in container.
24. purposes as claimed in claim 23, wherein
The container be 0.8mm or more via thickness and 2.5mm polyethylene shoulders below are to form made of ejiction opening
Tubular container.
25. a kind of inhibiting method of the oil-soluble effective component to the absorption of container, wherein
Dentifrice composition described in any one of claim 1~22 is contained in tubular container, the tubular container has
The innermost layer of polyethylene and via thickness for 0.8mm or more and 2.5mm polyethylene shoulders below to form ejiction opening and
At.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012242734A JP6072512B2 (en) | 2012-11-02 | 2012-11-02 | Dentifrice composition in a container |
| JP2012-242734 | 2012-11-02 | ||
| CN201380057412.2A CN104768526B (en) | 2012-11-02 | 2013-11-01 | Container fills dentifrice composition |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380057412.2A Division CN104768526B (en) | 2012-11-02 | 2013-11-01 | Container fills dentifrice composition |
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| Publication Number | Publication Date |
|---|---|
| CN108451786A true CN108451786A (en) | 2018-08-28 |
Family
ID=50627508
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380057412.2A Active CN104768526B (en) | 2012-11-02 | 2013-11-01 | Container fills dentifrice composition |
| CN201810472090.2A Pending CN108451786A (en) | 2012-11-02 | 2013-11-01 | Container fills dentifrice composition |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380057412.2A Active CN104768526B (en) | 2012-11-02 | 2013-11-01 | Container fills dentifrice composition |
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|---|---|
| JP (1) | JP6072512B2 (en) |
| CN (2) | CN104768526B (en) |
| RU (1) | RU2657773C2 (en) |
| TW (1) | TWI627970B (en) |
| WO (1) | WO2014069614A1 (en) |
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| JP6454093B2 (en) * | 2014-06-10 | 2019-01-16 | 花王株式会社 | Dentifrice composition in a container |
| US9884719B2 (en) | 2014-12-12 | 2018-02-06 | Symbotic, LLC | Storage and retrieval system |
| US11893533B2 (en) | 2015-01-16 | 2024-02-06 | Symbotic Llc | Storage and retrieval system |
| US10214355B2 (en) | 2015-01-16 | 2019-02-26 | Symbotic, LLC | Storage and retrieval system |
| US9856083B2 (en) | 2015-01-16 | 2018-01-02 | Symbotic, LLC | Storage and retrieval system |
| US10521767B2 (en) | 2015-01-16 | 2019-12-31 | Symbotic, LLC | Storage and retrieval system |
| US11254502B2 (en) | 2015-01-16 | 2022-02-22 | Symbotic Llc | Storage and retrieval system |
| US9850079B2 (en) | 2015-01-23 | 2017-12-26 | Symbotic, LLC | Storage and retrieval system transport vehicle |
| JP6985786B2 (en) * | 2015-04-07 | 2021-12-22 | ライオン株式会社 | Method for suppressing adsorption of isopropylmethylphenol to a dentifrice composition and a container in the dentifrice composition |
| JP7479254B2 (en) * | 2015-04-07 | 2024-05-08 | ライオン株式会社 | Dentifrice composition and method for inhibiting adsorption of isopropyl methylphenol to a container of a dentifrice composition |
| JP6580871B2 (en) * | 2015-06-02 | 2019-09-25 | 花王株式会社 | Toothpaste composition |
| WO2017078633A1 (en) * | 2015-11-02 | 2017-05-11 | Kimpai Lamitube Co., Ltd. | Tube container with shoulder made from melt-blended resin |
| MY192189A (en) * | 2016-05-30 | 2022-08-05 | Lion Corp | Composition for use in oral cavity |
| US11117743B2 (en) | 2017-09-28 | 2021-09-14 | Symbotic Llc | Storage and retrieval system |
| JP2022168043A (en) * | 2020-09-14 | 2022-11-04 | ライオン株式会社 | Dentifrice composition and method of inhibiting adsorption of isopropyl methylphenol to container of dentifrice composition |
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| JP3894132B2 (en) * | 2003-02-20 | 2007-03-14 | ライオン株式会社 | Dentifrice composition |
| JP4200374B2 (en) * | 2003-12-19 | 2008-12-24 | ライオン株式会社 | Dentifrice composition |
| RU2389665C1 (en) * | 2006-04-19 | 2010-05-20 | Колгейт-Палмолив Компани | Container for products containing aromatic compounds |
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- 2013-11-01 CN CN201380057412.2A patent/CN104768526B/en active Active
- 2013-11-01 WO PCT/JP2013/079661 patent/WO2014069614A1/en active Application Filing
- 2013-11-01 CN CN201810472090.2A patent/CN108451786A/en active Pending
- 2013-11-01 TW TW102139849A patent/TWI627970B/en active
- 2013-11-01 RU RU2015120736A patent/RU2657773C2/en active
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| JPH04300830A (en) * | 1991-03-28 | 1992-10-23 | Zeria Pharmaceut Co Ltd | Aqueous solution of vitamin es |
| JP2002241279A (en) * | 2001-02-16 | 2002-08-28 | Kanebo Ltd | Package-containing product and method for preventing adsorption |
| JP2005247786A (en) * | 2004-03-05 | 2005-09-15 | Lion Corp | Tooth paste composition and tooth paste product |
| CN102485781A (en) * | 2010-12-06 | 2012-06-06 | 中国石油化工股份有限公司 | Polyethylene composition for large-scale container lining |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2657773C2 (en) | 2018-06-15 |
| JP2014091698A (en) | 2014-05-19 |
| TWI627970B (en) | 2018-07-01 |
| CN104768526B (en) | 2018-06-19 |
| RU2015120736A (en) | 2016-12-27 |
| TW201434485A (en) | 2014-09-16 |
| JP6072512B2 (en) | 2017-02-01 |
| WO2014069614A1 (en) | 2014-05-08 |
| CN104768526A (en) | 2015-07-08 |
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