CN108420778A - A kind of composition and its application with white-skinned face function - Google Patents
A kind of composition and its application with white-skinned face function Download PDFInfo
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- CN108420778A CN108420778A CN201810626710.3A CN201810626710A CN108420778A CN 108420778 A CN108420778 A CN 108420778A CN 201810626710 A CN201810626710 A CN 201810626710A CN 108420778 A CN108420778 A CN 108420778A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
A kind of composition with white-skinned face function, includes the component of following parts by weight：Yushania（BAMBUSA VULGARIS）1 10 parts of extract, Herba Lamii albi（LAMIUM ALBUM）1 10 parts of extract, Codiumfragile(sur.) Hariot.（CODIUM FRAGILE）1 10 parts of extract.The lightening compositions of the present invention are arranged in pairs or groups mutually using a variety of natural extracts, each component is respectively acting on each approach of skin darkening, mutually collaboration, the activity of tyrosinase can effectively be inhibited, efficient scavenging activated oxygen, prevent the generation of melanin, decompose the melanin that desalination has been formed, significantly improve the whiteness and the colour of skin uniformity of skin, eliminate the dim mute, spot of the colour of skin, it is coarse the problems such as, also have effects that moisturizing, skin of releiving simultaneously, skin can be made gradually to restore whitening skin, delicacy, uniform healthy colour of skin state.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of composition and its application with white-skinned face function.
Background technology
People increasingly pursue the pale skin of health so that the demand of whitening product is more and more big.The color master of skin
If being determined according to quantity, size and distribution containing melanin in Skin Cell.For intracellular whitening approach, we
B16 cell should be prevented first, and it is relatively more to be directed to the research inhibited tyrosinase activity in this regard.Tyrosinase is one
Kind polyphenol enzyme, belongs to redox enzymes, which can be oxidized into DOPA and DOPA quinone with catalytic tyrosine and by DOPA
Pigment generates 5,6- dihydroxy indole carboxylic acids, generates melanin.Because the enzyme be catalyzed react when, it is necessary to have bivalent cupric ion and
There is the participation of oxygen radical, so removing has oxygen radical or complex copper ion tyrosinase can be made to lose activity, from
And it can not synthesis of melanin.The problem of inhibiting tyrosinase activity, modern society is mainly from two Study of way, first, tyrosine
The damage type of enzyme inhibits, and can directly the active site of tyrosinase be modified and is modified so that tyrosinase loses pair
The effect of melanocyte precursor-tyrosine；Second is that tyrosinase non-damage type inhibit, by inhibit tyrosinase biosynthesis or
It is by being at war with substrate tyrosine, to reach the formation for inhibiting melanin.Secondly the transmission of melanin should be prevented.Have
A little substances can inhibit the process that melanin granule is shifted from melanocyte to horn cell.Finally, melanin should be accelerated
Metabolism.It after melanin granule synthesis, on the one hand can be restored, so that the oxidation state melanin granule of black is restored becomes
The reproducibility melanin granule of white, secondly, the melanin granule being transferred in skin corium are mainly led to by the lysosome of cell
It crosses and has an effect with certain enzymes in lysosome, final catabolism falls, so, cell can be stimulated to generate lysosome by being added
Substance, come shorten cutin be metabolized the period, to accelerate falling off for cuticula.
Currently, general skin-whitening agents are mainly black by inhibiting tyrosinase activity or blocking tyrosinase to generate
The route of synthesis of pigment, the production to reduce melanin reach skin whitening effect.Such skin-whitening agents mainly have ursin,
Quinhydrones and derivative, L-AA and derivative, kojic acid and its derivative, Vitamin C Ethyl Ether and its derivative, nicotinoyl
Amine, Trenaxmine, benzenediol and its derivative etc..But above-mentioned skin-whitening agents cannot consider each of skin-whitening
Link, such as：From melanin production inducement, melanin production process, melanin digests discharge process etc. to the end.
Invention content
The technical problem to be solved in the present invention is to provide a kind of compositions with white-skinned face function.
The specific technical solution for solving above-mentioned technical problem is as follows：
A kind of composition with white-skinned face function, includes the component of following parts by weight：Yushania (BAMBUSA
VULGARIS) extract 1-10 parts, 1-10 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM
FRAGILE) extract 1-10 parts.
Preferably, the composition further includes 1-10 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield
1-10 parts of (BRASENIA SCHREBERI) leaf extract.
Preferably, the composition further includes 1-10 parts of Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract.
Preferably, the composition further includes wooden 1-10 parts of the extract of betula pendula (BETULA PENDULA).
It is described that there is U.S. the present invention also provides application of the composition with white-skinned face function in preparing cosmetics
The dosage of the composition of contour painting effect is 0.1-10 mass % when cosmetics are 100% mass.
Preferably, the cosmetics are cream.
A kind of whitening cream, each component containing following mass percentage：The above-mentioned composition with white-skinned face function
The smooth olive oleate 0.5-1.5% of 0.1-10%, cetostearyl alcohol 1-3%, saualane 0.1-2%, sorb, cetostearyl alcohol olive
Olive oleate 0.1-1%, dormant oil 1-5%, vaseline 0.1-2%, hydrogenated coco-glyceride class 0.1-3%, dimethyl silicone polymer
1-3%, cetearyl glucoside 0.1-1%, diisooctadecanol malate 0.1-2%, stearic acid 0.1-1%, the inulin moon
Osmanthus aminocarbamic acid ester 0.1-1%, bisabolol 0.1-0.3%, rape (BRASSICA CAMPESTRIS) sterols 0.1-
0.5%, tocopherol (vitamin E) 0.1-1%, Natrulon H-10 myristinate 0.1-0.5%, acryloyldimethyl taurine
Ammonium/VP copolymers 0.3-0.5%, hexyl decyl alcohol 0.1-2%, xanthans 0.1-0.3%, Sodium Hyaluronate 0.01-0.05%,
EDETATE SODIUM 0.01-0.05%, glycine betaine 1-3%, polyalcohol 5-15%, nephrite powder 0.1-1%, preservative 0.1-1%, more than water
Amount.
Preferably, the polyalcohol be erythritol, maltitol, mannitol, pentanediol, in 1,2- hexylene glycols at least
It is a kind of.
Preferably, the preservative is at least one of potassium sorbate, sodium benzoate, methyl hydroxybenzoate, Nipasol.
The present invention has the advantages that：
The lightening compositions of the present invention are arranged in pairs or groups mutually using a variety of natural extracts, and each component is respectively acting on skin
Each approach of skin blackening can effectively inhibit the activity of tyrosinase, efficient scavenging activated oxygen to prevent the production of melanin
It is raw, decompose the melanin that desalination has been formed, significantly improve the whiteness and the colour of skin uniformity of skin, eliminate the dim mute, spot of the colour of skin,
The problems such as coarse, while also having effects that moisturizing, skin of releiving, can make skin gradually restore whitening skin, delicacy,
Even healthy colour of skin state.
Description of the drawings
Fig. 1 is inhibiting effect of the whitening cream provided by the invention to tyrosinase activity.
Fig. 2 is opposite clearance rate of the whitening cream provided by the invention to DPPH free radicals.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Yushania (BAMBUSA VULGARIS) extract is extracted by yushania cauline leaf.Contain abundant minerals
Amino acid (amino acid) etc. help to maintain the long-acting moistening effect of skin, and with antibacterial, antioxidant effect, can have
Effect ground excludes the harmful substances such as heavy metal.Also contain abundant vitamin C, trace element and anthocyanidin etc., there is good toxin expelling
Effect helps improve skin quality, and long-time service skin is soft white, fine and smooth, has good opsonic action.
It is short that Herba Lamii albi (LAMIUM ALBUM) extract extracts from dicotyledon medicine Labiatae lamium plant
The herb of handle white dead nettle.Sweet, bitter, cold.Enter liver, kidney, bladder three to pass through.Herb contains saponin, tannin, caffeic acid and a variety of amino acid.
With anti-inflammatory, skin-active effect, there is inhibition to tyrosinase, makees whitening agent use in cosmetics.
Juniperus formosana Trentepohlia Chlorophyta is that (Codium fragile (sur.) Hariot.'s is tender for algae Codiaceae Codiumfragile(sur.) Hariot.
Frond is perennial worldwide warm temperate zone sea-plant, and Codiumfragile(sur.) Hariot. nature and flavor are sweet salty-cold, has clearing heat and detoxicating, detumescencing diuresis, expelling parasite
The effect of.Contain the trace quantity minerals member such as abundant protein, fat, dietary fiber, vitamin and Cu, Fe, Zn in Codiumfragile(sur.) Hariot.
Element.There is good effect to skin condition.
Lophatherum gracile (LOPHATHERUM GRACILE) extract extracts from grass henon bamboo leaf
The drying cauline leaf of Lophatherumgracile Brongn., nature and flavor are sweet, light, tremble with fear.Clearing heat and relieving fidgetness, diuresis.For pyreticosis polydipsia,
Hot urination leaching pain, aphthae.Contain the trace elements such as flavones, phenolic acid compound, amino acid, manganese, zinc.These effectively at
Activity in vivo oxygen radical can be removed by dividing；Induce the activity of the Antioxidant Enzymes inside organism；Enhance body resisting stress and
Anti-fatigue ability；Improve memory capability, the process etc. of anti-aging.In addition, also containing abundant chlorophyll in the leaf of bamboo.Chlorophyll
It is the important component of many vegetables antimutagenesis, there is stronger anti-oxidation function.The distinctive fragrant of the leaf of bamboo simultaneously, and it is right
Bacterium, yeast and mold all have strong inhibiting effect.
Water shield (scientific name：Brasenia schreberi J.F.Gmel.) it is perennial aquatic perennial root draft, You Ming Po dishes,
Horseshoe dish, lake dish etc..Property happiness it is warm, be suitable for clear water reserviors growth.Water shield contains abundant colloid albumen, carbohydrate, fat
Fat, multivitamin and minerals, often feeding water shield have the health-care effect of medicine-food two-purpose.Water shield have heat-clearing, Li Shui, detumescence,
The effect of removing toxic substances.Control hot dysentery, yellow subcutaneous ulcer, carbuncle swells, furunculosis.With all herbal medicine.It is sweet in flavor, it is cold in nature.Cure mainly clearing heat and detoxicating, preventing or arresting vomiting.It cures mainly
High blood pressure, rush down dysentery are had a stomachache, and vomiting, gastric disorder causing nausea, ulcer malignant boil is swollen, furuncle.The mucilaginous substance of water shield is containing there are many nutriment and more contractings
Pentose has preferable antipyretic and antidote functions, and the growth of bacterium, the clearing stomach fire of food can be inhibited to rush down intestines heat, ulcer can be controlled by mashing external application
Furunculosis.This mucus of water shield leaf can form layer protecting film in skin surface, make it have antipollution and (inhibit AHR and CYP
The expression of 1H1, protects the skin against heavy metal) and anti-oxidation efficacy, while more juicy can be also lockked, improve skin moisturizing
Degree.
Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract, containing abundant galactomannans, in skin surface
One layer of flexible and non-blocking film is formed, can compact lifting skin.It has the multiple pipe three-dimensional matrix of similar bamboo microtubular
Active matter can be finely configured in cream by structure by slow release method according to golden ratio, and being applied to can slowly release afterwards on the face
These active matters are put, while itself being also a kind of chitosan component, can absorb water from air, enable moisturizing more longlasting.In the present invention
In, the stability of cream can be increased, keep lotion finer and smoother.
Betula pendula (BETULA PENDULA) wood extract extracts from the bark of Betulaceae birch platymiscium betula pendula.It is bitter；
It is mild-natured, (leucoanthocyanins) containing grey glucoside, pentosan, the aliphatic ester of terpene and sterol, flavonols
(flavonol) and catechol (catechol) etc..In the present invention, the whiteness of skin can be improved.
Embodiment 1
A kind of whitening cream, each component containing following mass percentage：Composition 0.1% with white-skinned face function,
The smooth olive oleate 1.5% of cetostearyl alcohol 1%, saualane 0.1%, sorb, cetostearyl alcohol olive oleate 1%, dormant oil
1%, vaseline 2%, hydrogenated coco-glyceride class 0.1%, dimethyl silicone polymer 1%, cetearyl glucoside 0.1%, two
Isooctadecanol malate 2%, stearic acid 0.1%, inulin lauryl carbamate 0.1%, bisabolol 0.3%, rape
(BRASSICA CAMPESTRIS) sterols 0.1%, tocopherol (vitamin E) 1%, Natrulon H-10 myristinate 0.1%,
Ammonium acryloyl taurate/VP copolymer 0.5%, hexyl decyl alcohol 0.1%, xanthans 0.1%, Sodium Hyaluronate
0.05%, EDETATE SODIUM 0.05%, glycine betaine 3%, pentanediol 15%, nephrite powder 1%, methyl hydroxybenzoate 0.1%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 10 parts of extract, 1 part of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE)
10 parts of extract.
Embodiment 2
A kind of whitening cream, each component containing following mass percentage：Composition 10% with white-skinned face function, whale
The smooth olive oleate 0.5% of wax stearyl alcohol 3%, saualane 2%, sorb, cetostearyl alcohol olive oleate 0.1%, dormant oil
5%, vaseline 0.1%, hydrogenated coco-glyceride class 0.1%, dimethyl silicone polymer 3%, cetearyl glucoside 1%, two
Isooctadecanol malate 0.1%, stearic acid 1%, inulin lauryl carbamate 1%, bisabolol 0.1%, rape
(BRASSICA CAMPESTRIS) sterols 0.5%, tocopherol (vitamin E) 0.1%, Natrulon H-10 myristinate
0.5%, ammonium acryloyl taurate/VP copolymer 0.3%, hexyl decyl alcohol 2%, xanthans 0.3%, Sodium Hyaluronate
0.01%, EDETATE SODIUM 0.01%, glycine betaine 1%, maltitol 5%, nephrite powder 0.1%, potassium sorbate 1%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 1 part of extract, 10 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE)
1 part of extract.
Embodiment 3
A kind of whitening cream, each component containing following mass percentage：Composition 5% with white-skinned face function, whale
The smooth olive oleate 0.8% of wax stearyl alcohol 2%, saualane 0.9%, sorb, cetostearyl alcohol olive oleate 0.5%, dormant oil
3%, vaseline 1%, hydrogenated coco-glyceride class 0.5%, dimethyl silicone polymer 2%, cetearyl glucoside 0.5%, two
Isooctadecanol malate 1%, stearic acid 0.5%, inulin lauryl carbamate 0.6%, bisabolol 0.2%, rape
(BRASSICA CAMPESTRIS) sterols 0.5%, tocopherol (vitamin E) 0.5%, Natrulon H-10 myristinate
0.3%, ammonium acryloyl taurate/VP copolymer 0.4%, hexyl decyl alcohol 1.2%, xanthans 0.2%, Sodium Hyaluronate
0.03%, EDETATE SODIUM 0.03%, glycine betaine 2%, mannitol 10%, nephrite powder 0.5%, sodium benzoate 0.5%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 5 parts of extract, 5 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 5 parts of object.
Embodiment 4
A kind of whitening cream, each component containing following mass percentage：Composition 3% with white-skinned face function, whale
The smooth olive oleate 0.6% of wax stearyl alcohol 1.5%, saualane 0.4%, sorb, cetostearyl alcohol olive oleate 0.4%, mine
Oil 2%, vaseline 1.8%, hydrogenated coco-glyceride class 0.8%, dimethyl silicone polymer 1.4%, cetearyl glucoside
0.2%, diisooctadecanol malate 1.4%, stearic acid 0.4%, inulin lauryl carbamate 0.5%, bisabolol
0.15%, rape (BRASSICA CAMPESTRIS) sterols 0.3%, tocopherol (vitamin E) 0.2%, Natrulon H-10 meat
Myristate 0.3%, ammonium acryloyl taurate/VP copolymer 0.5%, hexyl decyl alcohol 1.8%, xanthans 0.3%, thoroughly
Bright matter acid sodium 0.04%, EDETATE SODIUM 0.02%, glycine betaine 1.5%, maltitol 4%, mannitol 4%, nephrite powder 0.9%,
Nipasol 0.2%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 3 parts of extract, 7 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 2 parts of object, 1 part of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield (BRASENIA SCHREBERI) leaf extract
10 parts.
Embodiment 5
A kind of whitening cream, each component containing following mass percentage：Composition 7% with white-skinned face function, whale
The smooth olive oleate 0.9% of wax stearyl alcohol 2.5%, saualane 1.7%, sorb, cetostearyl alcohol olive oleate 0.6%, mine
Oil 1.5%, vaseline 1.4%, hydrogenated coco-glyceride class 0.6%, dimethyl silicone polymer 2.7%, cetearyl glucoside
0.3%, diisooctadecanol malate 1.5%, stearic acid 0.7%, inulin lauryl carbamate 0.9%, bisabolol
0.25%, rape (BRASSICA CAMPESTRIS) sterols 0.4%, tocopherol (vitamin E) 0.3%, Natrulon H-10 meat
Myristate 0.4%, ammonium acryloyl taurate/VP copolymer 0.3%, hexyl decyl alcohol 1.5%, xanthans 0.1%, thoroughly
It is bright matter acid sodium 0.02%, EDETATE SODIUM 0.05%, glycine betaine 1.8%, maltitol 4%, mannitol 4%, pentanediol 4%, soft
Beautiful powder 0.2%, methyl hydroxybenzoate 0.2%, Nipasol 0.1%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 8 parts of extract, 4 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 7 parts of object, 10 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, the extraction of water shield (BRASENIA SCHREBERI) leaf
1 part of object.
Embodiment 6
A kind of whitening cream, each component containing following mass percentage：Composition 5% with white-skinned face function, whale
The smooth olive oleate 0.7% of wax stearyl alcohol 1.8%, saualane 1.2%, sorb, cetostearyl alcohol olive oleate 0.5%, mine
Oil 2.5%, vaseline 1.5%, hydrogenated coco-glyceride class 0.4%, dimethyl silicone polymer 2.8%, cetearyl glucoside
0.4%, diisooctadecanol malate 1.2%, stearic acid 0.6%, inulin lauryl carbamate 0.8%, bisabolol
0.3%, rape (BRASSICA CAMPESTRIS) sterols 0.2%, tocopherol (vitamin E) 0.4%, Natrulon H-10 Pork and beans
It is cool acid esters 0.2%, ammonium acryloyl taurate/VP copolymer 0.4%, hexyl decyl alcohol 0.3%, xanthans 0.2%, transparent
Matter acid sodium 0.03%, EDETATE SODIUM 0.03%, glycine betaine 1.2%, mannitol 3%, pentanediol 3%, nephrite powder 0.3%, oxybenzene
Methyl esters 0.2%, Nipasol 0.2%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 5 parts of extract, 5 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 5 parts of object, 5 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield (BRASENIA SCHREBERI) leaf extract
5 parts.
Embodiment 7
A kind of whitening cream, each component containing following mass percentage：Composition 2% with white-skinned face function, whale
The smooth olive oleate 1% of wax stearyl alcohol 1.4%, saualane 1.4%, sorb, cetostearyl alcohol olive oleate 0.7%, dormant oil
3.5%, vaseline 1.2%, hydrogenated coco-glyceride class 1%, dimethyl silicone polymer 2.3%, cetearyl glucoside
0.5%, diisooctadecanol malate 0.4%, stearic acid 0.4%, inulin lauryl carbamate 0.7%, bisabolol
0.1%, rape (BRASSICA CAMPESTRIS) sterols 0.3%, tocopherol (vitamin E) 0.5%, Natrulon H-10 Pork and beans
It is cool acid esters 0.4%, ammonium acryloyl taurate/VP copolymer 0.5%, hexyl decyl alcohol 0.4%, xanthans 0.2%, transparent
Matter acid sodium 0.04%, EDETATE SODIUM 0.04%, glycine betaine 2.5%, erythritol 4%, maltitol 3%, nephrite powder 0.4%,
Potassium sorbate 0.5%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 2 parts of extract, 6 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 9 parts of object, 3 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield (BRASENIA SCHREBERI) leaf extract
7 parts, 1 part of Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract.
Embodiment 8
A kind of whitening cream, each component containing following mass percentage：Composition 8% with white-skinned face function, whale
The smooth olive oleate 1.2% of wax stearyl alcohol 2.2%, saualane 1.8%, sorb, cetostearyl alcohol olive oleate 0.9%, mine
Oil 4.5%, vaseline 1%, hydrogenated coco-glyceride class 1.5%, dimethyl silicone polymer 1.6%, cetearyl glucoside
0.6%, diisooctadecanol malate 1%, stearic acid 0.3%, inulin lauryl carbamate 0.6%, bisabolol
0.2%, rape (BRASSICA CAMPESTRIS) sterols 0.2%, tocopherol (vitamin E) 0.6%, Natrulon H-10 Pork and beans
It is cool acid esters 0.1%, ammonium acryloyl taurate/VP copolymer 0.3%, hexyl decyl alcohol 0.7%, xanthans 0.1%, transparent
Matter acid sodium 0.05%, EDETATE SODIUM 0.05%, glycine betaine 2.8%, erythritol 4%, pentanediol 5%, nephrite powder 0.6%, benzene
Sodium formate 0.6%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 4 parts of extract, 2 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 4 parts of object, 7 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield (BRASENIA SCHREBERI) leaf extract
3 parts, 10 parts of Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract.
Embodiment 9
A kind of whitening cream, each component containing following mass percentage：Composition 5% with white-skinned face function, whale
The smooth olive oleate 1.3% of wax stearyl alcohol 2.6%, saualane 1.5%, sorb, cetostearyl alcohol olive oleate 0.8%, mine
Oil 3.8%, vaseline 0.9%, hydrogenated coco-glyceride class 2%, dimethyl silicone polymer 1.8%, cetearyl glucoside
0.7%, diisooctadecanol malate 0.5%, stearic acid 0.2%, inulin lauryl carbamate 0.4%, bisabolol
0.2%, rape (BRASSICA CAMPESTRIS) sterols 0.4%, tocopherol (vitamin E) 0.7%, Natrulon H-10 Pork and beans
It is cool acid esters 0.5%, ammonium acryloyl taurate/VP copolymer 0.4%, hexyl decyl alcohol 0.5%, xanthans 0.3%, transparent
Matter acid sodium 0.01%, EDETATE SODIUM 0.01%, glycine betaine 2.2%, maltitol 5%, mannitol 6%, nephrite powder 0.7%, mountain
Potassium sorbate 0.4%, sodium benzoate 0.3%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 5 parts of extract, 5 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 5 parts of object, 5 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield (BRASENIA SCHREBERI) leaf extract
5 parts, 5 parts of Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract.
Embodiment 10
A kind of whitening cream, each component containing following mass percentage：Composition 4% with white-skinned face function, whale
The smooth olive oleate 1.4% of wax stearyl alcohol 1.7%, saualane 0.6%, sorb, cetostearyl alcohol olive oleate 0.3%, mine
Oil 1.8%, vaseline 0.7%, hydrogenated coco-glyceride class 2.5%, dimethyl silicone polymer 2.5%, cetearyl glucoside
0.8%, diisooctadecanol malate 0.7%, stearic acid 0.8%, inulin lauryl carbamate 0.3%, bisabolol
0.3%, rape (BRASSICA CAMPESTRIS) sterols 0.3%, tocopherol (vitamin E) 0.8%, Natrulon H-10 Pork and beans
It is cool acid esters 0.4%, ammonium acryloyl taurate/VP copolymer 0.4%, hexyl decyl alcohol 0.8%, xanthans 0.3%, transparent
Matter acid sodium 0.04%, EDETATE SODIUM 0.04%, glycine betaine 2.4%, maltitol 13%, nephrite powder 0.9%, potassium sorbate
0.4%, sodium benzoate 0.4%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 6 parts of extract, 3 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 6 parts of object, 4 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield (BRASENIA SCHREBERI) leaf extract
8 parts, 1 part of Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract.
Embodiment 11
A kind of whitening cream, each component containing following mass percentage：Composition 6% with white-skinned face function, whale
The smooth olive oleate 1.1% of wax stearyl alcohol 1.2%, saualane 0.8%, sorb, cetostearyl alcohol olive oleate 0.2%, mine
Oil 2.6%, vaseline 0.8%, hydrogenated coco-glyceride class 2.8%, dimethyl silicone polymer 1.5%, cetearyl glucoside
0.9%, diisooctadecanol malate 0.9%, stearic acid 0.9%, inulin lauryl carbamate 0.2%, bisabolol
0.1%, rape (BRASSICA CAMPESTRIS) sterols 0.2%, tocopherol (vitamin E) 0.9%, Natrulon H-10 Pork and beans
It is cool acid esters 0.2%, ammonium acryloyl taurate/VP copolymer 0.2%, hexyl decyl alcohol 0.9%, xanthans 0.1%, transparent
Matter acid sodium 0.02%, EDETATE SODIUM 0.02%, glycine betaine 2.3%, erythritol 14%, nephrite powder 0.8%, potassium sorbate
0.5%, sodium benzoate 0.4%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 7 parts of extract, 8 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 3 parts of object, 6 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield (BRASENIA SCHREBERI) leaf extract
4 parts, 10 parts of Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract.
Embodiment 12
A kind of whitening cream, each component containing following mass percentage：Composition 5% with white-skinned face function, whale
The smooth olive oleate 0.8% of wax stearyl alcohol 2.3%, saualane 0.5%, sorb, cetostearyl alcohol olive oleate 0.5%, mine
Oil 3%, vaseline 0.5%, hydrogenated coco-glyceride class 1.8%, dimethyl silicone polymer 2%, cetearyl glucoside
0.5%, diisooctadecanol malate 0.8%, stearic acid 0.5%, inulin lauryl carbamate 0.5%, bisabolol
0.3%, rape (BRASSICA CAMPESTRIS) sterols 0.3%, tocopherol (vitamin E) 0.5%, Natrulon H-10 Pork and beans
Cool acid esters 0.3%, ammonium acryloyl taurate/VP copolymer 0.4%, hexyl decyl alcohol 1%, xanthans 0.2%, hyalomitome
Sour sodium 0.03%, EDETATE SODIUM 0.03%, glycine betaine 2.2%, 1,2- hexylene glycols 10%, nephrite powder 0.5%, potassium sorbate
0.5%, water surplus.
The composition with white-skinned face function is grouped as by the group of following parts by weight：Yushania (BAMBUSA
VULGARIS) 5 parts of extract, 5 parts of Herba Lamii albi (LAMIUM ALBUM) extract, Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) carry
Take 5 parts of object, 5 parts of lophatherum gracile (LOPHATHERUM GRACILE) extract, water shield (BRASENIA SCHREBERI) leaf extract
5 parts, 5 parts of Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract.
Comparative example 1
A kind of whitening cream, each component containing following mass percentage：Yushania (BAMBUSA VULGARIS) carries
Take the smooth olive oleate 0.8% of object 5%, cetostearyl alcohol 2%, saualane 0.9%, sorb, cetostearyl alcohol olive oleate
0.5%, dormant oil 3%, vaseline 1%, hydrogenated coco-glyceride class 0.5%, dimethyl silicone polymer 2%, cetearyl glucose
Glycosides 0.5%, diisooctadecanol malate 1%, stearic acid 0.5%, inulin lauryl carbamate 0.6%, bisabolol
0.2%, rape (BRASSICA CAMPESTRIS) sterols 0.5%, tocopherol (vitamin E) 0.5%, Natrulon H-10 Pork and beans
It is cool acid esters 0.3%, ammonium acryloyl taurate/VP copolymer 0.4%, hexyl decyl alcohol 1.2%, xanthans 0.2%, transparent
Matter acid sodium 0.03%, EDETATE SODIUM 0.03%, glycine betaine 2%, mannitol 10%, nephrite powder 0.5%, sodium benzoate 0.5%, water
Surplus.
Comparative example 2
A kind of whitening cream, each component containing following mass percentage：Herba Lamii albi (LAMIUM ALBUM) carries
Take the smooth olive oleate 0.8% of object 5%, cetostearyl alcohol 2%, saualane 0.9%, sorb, cetostearyl alcohol olive oleate
0.5%, dormant oil 3%, vaseline 1%, hydrogenated coco-glyceride class 0.5%, dimethyl silicone polymer 2%, cetearyl glucose
Glycosides 0.5%, diisooctadecanol malate 1%, stearic acid 0.5%, inulin lauryl carbamate 0.6%, bisabolol
0.2%, rape (BRASSICA CAMPESTRIS) sterols 0.5%, tocopherol (vitamin E) 0.5%, Natrulon H-10 Pork and beans
It is cool acid esters 0.3%, ammonium acryloyl taurate/VP copolymer 0.4%, hexyl decyl alcohol 1.2%, xanthans 0.2%, transparent
Matter acid sodium 0.03%, EDETATE SODIUM 0.03%, glycine betaine 2%, mannitol 10%, nephrite powder 0.5%, sodium benzoate 0.5%, water
Surplus.
Comparative example 3
A kind of whitening cream, each component containing following mass percentage：Codiumfragile(sur.) Hariot. (CODIUM FRAGILE) extracts
The smooth olive oleate 0.8% of object 5%, cetostearyl alcohol 2%, saualane 0.9%, sorb, cetostearyl alcohol olive oleate
0.5%, dormant oil 3%, vaseline 1%, hydrogenated coco-glyceride class 0.5%, dimethyl silicone polymer 2%, cetearyl glucose
Glycosides 0.5%, diisooctadecanol malate 1%, stearic acid 0.5%, inulin lauryl carbamate 0.6%, bisabolol
0.2%, rape (BRASSICA CAMPESTRIS) sterols 0.5%, tocopherol (vitamin E) 0.5%, Natrulon H-10 Pork and beans
It is cool acid esters 0.3%, ammonium acryloyl taurate/VP copolymer 0.4%, hexyl decyl alcohol 1.2%, xanthans 0.2%, transparent
Matter acid sodium 0.03%, EDETATE SODIUM 0.03%, glycine betaine 2%, mannitol 10%, nephrite powder 0.5%, sodium benzoate 0.5%, water
Surplus.
In order to better illustrate advantages of the present invention, the test experience data of the present invention are given below：
1, to the inhibiting effect of tyrosinase activity
1.1 experimental method
The whitening cream that laboratory sample is embodiment 1-12, prepared by comparative example 1-3 also has ursin, uses pH value 6.8 in advance
Phosphate buffer solution (PBS) dilute 10 times be prepared into sample solution.Respectively it is added 1.0ml's in sample cell and sample controls pipe
Then decibel is added for the solution of embodiment 1-12, the sample solution of comparative example 1-3 and ursin, negative control pipe and blank control pipe
The PBS of 1.0ml.Respectively be added the 0.35mol/L tyrosine enzyme solutions of 0.5ml in sample cell and negative control pipe, sample controls with
Blank control pipe is replaced with 0.5ml PBS, and concussion shakes up, and 30 DEG C of sinks are incubated 10min.It is added 1ml's in each pipe
0.01mol/L DOPA solution continues to be incubated 5min, measures absorbance at 475nm immediately.
The inhibiting rate of tyrosinase activity is calculated by following formula：
In inhibiting rate (%)=formula：T- sample cell light absorption values；T0- sample controls pipe light absorption values；C- negative control pipe extinctions
Value；C0- blank control pipe light absorption values.
1.2 experimental result
Experimental result is shown in Fig. 1.From figure 1 it appears that the whitening cream of embodiment 1-12 all has inhibits junket well
The effect of propylhomoserin enzymatic activity, inhibiting rate reach 78% or more, more more excellent than comparative example 1-3 and exclusive use ursin.Explanation
The composition of the present invention has mutually synergistic effect, has significant white-skinned face function.
2, the inhibiting effect that the melanin of the melanoma cells of culture is generated
2.1 experimental method
The B16 cells of logarithmic growth phase prepare single cell suspension through digesting dispersion, count.By cell inoculation to 6 holes
Coring tissue culture plates, inoculum density are 1 × 106A/hole, amount of liquid are per hole 2ml.Overnight, it waits for that cell is adherent, sucks training
Nutrient solution handles factor (1 × 10 with containing various concentration2, 1 × 105) 50 μ g/ml of 2 kinds of concentration and positive control drug-ursin)
Fresh culture change liquid 1 time, culture solution and corresponding solvent is only added in blank control group, continues to cultivate 72h, drug-treated terminates
When, cell is collected with trypsase, PBS is washed 2 times after centrifugation, adds 20 μ L tri-distilled waters that precipitation is made to suspend, then adds the ethyl alcohol of 200 μ L:
Ether (1:1) mixed liquor stands 20min at room temperature, and 3000r/min centrifuges 5min, and precipitation plus 200 μ L of 1N NaOH (contain 10%
DMSO), it is incubated 30min in 80 DEG C of water-baths, its absorbance in 420nm is surveyed with microplate reader.It is measured simultaneously with MTT reduction methods each
The survivability of the cell of kind substance.Melanocyte amount is indicated with (× 100).
Melanin genesis inhibiting rate=[1- (drug-treated group A420nm values/drug-treated group cell number)/(blank control group
A420nm/ blank control groups cell number)] × 100%
2.2 experimental result
Experimental result is shown in Table 1. and inhibits B16 intracellular from table 1 it follows that the whitening cream of embodiment 1-12 all has
The effect of melanin product, and with the increase of experimental concentration, inhibiting rate increases, more more excellent than comparative example 1-3.Illustrate this hair
Bright composition mutually acts synergistically, and has significant white-skinned face function.
Inhibiting rate (%) of the table 1 to melanin production
| Dilution 1 × 102 | Dilution 1 × 105 | |
| Embodiment 1 | 37.5 | 19.7 |
| Embodiment 2 | 38.3 | 19.8 |
| Embodiment 3 | 39.4 | 20.3 |
| Embodiment 4 | 41.5 | 21.6 |
| Embodiment 5 | 41.2 | 21.5 |
| Embodiment 6 | 42.6 | 22.4 |
| Embodiment 7 | 43.7 | 22.9 |
| Embodiment 8 | 43.1 | 23.1 |
| Embodiment 9 | 44.3 | 24.7 |
| Embodiment 10 | 45.5 | 26.4 |
| Embodiment 11 | 45.1 | 26.2 |
| Embodiment 12 | 47.6 | 28.1 |
| Comparative example 1 | 16.8 | 8.2 |
| Comparative example 2 | 15.5 | 7.8 |
| Comparative example 3 | 17.6 | 8.4 |
| Ursin | 25.4 | 12.4 |
3, antioxidant activity is tested
3.1 experimental method
Compound concentration is sample, the positive control ursin storing solution of 1mM；DPPH 1.4mg are taken to add 17.5mL absolute ethyl alcohols
Up to the DPPH solution of 0.2mmol/L；Take the sample solution (test material) of the 100 above-mentioned various concentrations of μ L that 96 hole elisa Plates are added
In, the 100 μ L of DPPH solution of matching while using are then added, it is 20,40,60,80,100 μM to make sample effect ultimate density.Enzyme mark
Plate keeps the temperature absorbance value (As) of the determination sample under 517nm wavelength after 30min at 30 DEG C, while measuring and being not added with DPPH freedom
Sample blank (100 μ L absolute ethyl alcohols the replace DPPH) light absorption value (Ac) of base reagent and plus DPPH free radicals reagent but it is not added with sample
The light absorption value (Amax) of (100 μ L absolute ethyl alcohols replace sample), calculate free radical with respect to clearance rate (%)=[1- (As-Ac)/
Amax] × 100%.
3.2 experimental result
Experimental result is shown in Fig. 2.From figure 2 it can be seen that the whitening cream of embodiment 1-12, which all has, removes free radical
Ability.Its oxidation resistance of composition of the present invention is more more excellent than ursin is used alone.
4, trial effect is verified
The effect of in order to assess whitening cream of the present invention, is volunteering product made from embodiment 1-12 and comparative example 1-3
Person tests with it, every group of 50 people, is used continuously 4 weeks, and observation uses as a result, as shown in table 2：
Table 2
It can be seen that from above-mentioned table 2, whitening cream of the present invention grows skin whiteness and the colour of skin uniformity, spot, obscure, skin
Profit sophistication has larger improvement, and improvement is more more excellent than comparative example 1-3, has synergistic function.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (10)
1. a kind of composition with white-skinned face function, which is characterized in that include the component of following parts by weight：Yushania（BAMBUSA
VULGARIS）1-10 parts of extract, Herba Lamii albi（LAMIUM ALBUM）1-10 parts of extract, Codiumfragile(sur.) Hariot.（CODIUM
FRAGILE）1-10 parts of extract.
2. the composition according to claim 1 with white-skinned face function, which is characterized in that the composition further includes henon bamboo
Leaf（LOPHATHERUM GRACILE）1-10 parts of extract, water shield（BRASENIA SCHREBERI）1-10 parts of leaf extract.
3. the composition according to claim 1 with white-skinned face function, which is characterized in that the composition further includes thorn cloud
It is real（CAESALPINIA SPINOSA）1-10 parts of berry extract.
4. the composition according to claim 1 with white-skinned face function, which is characterized in that the composition further includes weeping branch
Birch（BETULA PENDULA）Wooden extract 1-10 parts.
5. there is application of the composition of white-skinned face function in preparing cosmetics according to claim 1-4 any one of them.
6. application according to claim 5, which is characterized in that the dosage of the composition with white-skinned face function is being changed
It is 0.1-10 mass % when cosmetic is 100% mass.
7. application according to claim 5, which is characterized in that the cosmetics are cream.
8. a kind of whitening cream, which is characterized in that each component containing following mass percentage：As claim 1-4 is any
The composition 0.1-10% with white-skinned face function, cetostearyl alcohol 1-3%, saualane 0.1-2%, the smooth olive oil of sorb described in
Acid esters 0.5-1.5%, cetostearyl alcohol olive oleate 0.1-1%, dormant oil 1-5%, vaseline 0.1-2%, hydrogenated coco-glyceride class
It is 0.1-3%, dimethyl silicone polymer 1-3%, cetearyl glucoside 0.1-1%, diisooctadecanol malate 0.1-2%, hard
Resin acid 0.1-1%, inulin lauryl carbamate 0.1-1%, bisabolol 0.1-0.3%, rape（BRASSICA
CAMPESTRIS）Sterols 0.1-0.5%, tocopherol（Vitamin E）0.1-1%, Natrulon H-10 myristinate 0.1-0.5%,
Ammonium acryloyldime-thyltaurate/VP copolymers 0.3-0.5%, hexyl decyl alcohol 0.1-2%, xanthans 0.1-0.3%, hyaluronic acid
Sodium 0.01-0.05%, EDTA disodium 0.01-0.05%, glycine betaine 1-3%, polyalcohol 5-15%, nephrite powder 0.1-1%, preservative
0.1-1%, water surplus.
9. whitening cream according to claim 8, which is characterized in that the polyalcohol is erythritol, maltitol, sweet
Reveal at least one of alcohol, pentanediol, 1,2- hexylene glycols.
10. whitening cream according to claim 8, which is characterized in that the preservative be potassium sorbate, sodium benzoate,
At least one of methyl hydroxybenzoate, Nipasol.
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| CN113712872A (en) * | 2021-09-26 | 2021-11-30 | 湖北省麦诗特生物科技有限公司 | Essence emulsion composition containing liposome with skin brightening and whitening effects and preparation method thereof |
| CN113956369A (en) * | 2021-10-21 | 2022-01-21 | 河南省医药科学研究院 | Preparation method and application of Caryopteris clandonensis polysaccharide |
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